ryanodine and sphingosine-phosphorylcholine

ryanodine has been researched along with sphingosine-phosphorylcholine* in 1 studies

Other Studies

1 other study(ies) available for ryanodine and sphingosine-phosphorylcholine

Article	Year
Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes. Acta neurobiologiae experimentalis, 2001, Volume: 61, Issue:2 Sphingosylphosphorylcholine (SPC) induces a rapid increase of intracellular Ca2+ concentration in isolated synaptosomes. This effect is dose-dependent and is also dependent on extracellular Ca2+. Sphingosine (SPH) has a smaller effect and treatment with psychosine (PSY) is ineffective, which suggests that phosphorylation of the 1-carbon of SPH is required for the SPC to act as a Ca2+ release agonist in synaptosomes. Experiments performed in the presence of heparin or ryanodine indicate that SPC-elicited Ca2+ release is not mediated by IP3 or ryanodine receptors. Finally, our results show that the effect of SPC on Ca2+ concentration is nimodipine-sensitive, suggesting that SPC possibly activates a specific sphingolipid-gated Ca2+ channel in synaptosomes. Topics: Animals; Anticoagulants; Calcium; Calcium Channel Blockers; Heparin; Nimodipine; Phosphorylcholine; Psychosine; Rats; Ryanodine; Sphingolipids; Sphingosine; Synaptosomes	2001

Article

Year

Sphingolipid derivatives modulate intracellular Ca2+ in rat synaptosomes.

Acta neurobiologiae experimentalis, 2001, Volume: 61, Issue:2

Sphingosylphosphorylcholine (SPC) induces a rapid increase of intracellular Ca2+ concentration in isolated synaptosomes. This effect is dose-dependent and is also dependent on extracellular Ca2+. Sphingosine (SPH) has a smaller effect and treatment with psychosine (PSY) is ineffective, which suggests that phosphorylation of the 1-carbon of SPH is required for the SPC to act as a Ca2+ release agonist in synaptosomes. Experiments performed in the presence of heparin or ryanodine indicate that SPC-elicited Ca2+ release is not mediated by IP3 or ryanodine receptors. Finally, our results show that the effect of SPC on Ca2+ concentration is nimodipine-sensitive, suggesting that SPC possibly activates a specific sphingolipid-gated Ca2+ channel in synaptosomes.

Topics: Animals; Anticoagulants; Calcium; Calcium Channel Blockers; Heparin; Nimodipine; Phosphorylcholine; Psychosine; Rats; Ryanodine; Sphingolipids; Sphingosine; Synaptosomes

2001