ryanodine and pulegone

ryanodine has been researched along with pulegone* in 1 studies

Other Studies

1 other study(ies) available for ryanodine and pulegone

ArticleYear
A 15-step synthesis of (+)-ryanodol.
    Science (New York, N.Y.), 2016, 08-26, Volume: 353, Issue:6302

    (+)-Ryanodine and (+)-ryanodol are complex diterpenoids that modulate intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission. Chemical derivatization of these diterpenoids has demonstrated that certain peripheral structural modifications can alter binding affinity and selectivity among ryanodine receptor isoforms. Here, we report a short chemical synthesis of (+)-ryanodol that proceeds in only 15 steps from the commercially available terpene (S)-pulegone. The efficiency of the synthesis derives from the use of a Pauson-Khand reaction to rapidly build the carbon framework and a SeO2-mediated oxidation to install three oxygen atoms in a single step. This work highlights how strategic C-O bond constructions can streamline the synthesis of polyhydroxylated terpenes by minimizing protecting group and redox adjustments.

    Topics: Biological Products; Cyclohexane Monoterpenes; Monoterpenes; Oxidation-Reduction; Oxygen; Ryanodine; Ryanodine Receptor Calcium Release Channel; Selenium Oxides

2016