ryanodine and magnolol

ryanodine has been researched along with magnolol* in 1 studies

Other Studies

1 other study(ies) available for ryanodine and magnolol

ArticleYear
Magnolol induces cytosolic-free Ca2+ elevation in rat neutrophils primarily via inositol trisphosphate signalling pathway.
    European journal of pharmacology, 1998, Jul-10, Volume: 352, Issue:2-3

    In the present study, we describe the role of inositol trisphosphate in the signalling pathway that leads to the elevation of cytosolic-free Ca2+ in rat neutrophils stimulated with magnolol, a compound isolated from the cortex of Magnolia officinalis. Magnolol increased [Ca2+]i, by stimulating Ca2+ release from internal stores and Ca2+ influx across the plasma membrane, in a concentration-dependent manner. Ni2+ and [6-[[(17beta)-3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H -pyrrole-2,5-dione (U73122), but not pertussis toxin, inhibited the magnolol-induced Ca2+ influx. Measurement of cellular levels of inositol trisphosphate showed a clear increase upon exposure to magnolol. U73122 but not ryanodine suppressed the Ca2+ release from internal stores caused by magnolol. Pretreatment of cells with formyl-Met-Leu-Phe (fMLP) or cyclopiazonic acid greatly reduced the [Ca2+]i changes caused by the subsequent addition of magnolol. Collectively, these findings suggest that a pertussis toxin-insensitive inositol trisphosphate signalling pathway is involved in the magnolol-induced [Ca2+]i elevation in rat neutrophils.

    Topics: Animals; Biphenyl Compounds; Calcium; Cytosol; Estrenes; In Vitro Techniques; Indoles; Inositol 1,4,5-Trisphosphate; Lignans; Manganese; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pyrrolidinones; Rats; Ryanodine; Signal Transduction

1998