rx 821002 has been researched along with yohimbine in 61 studies
| Studies (rx 821002) | Trials (rx 821002) | Recent Studies (post-2010) (rx 821002) | Studies (yohimbine) | Trials (yohimbine) | Recent Studies (post-2010) (yohimbine) |
|---|---|---|---|---|---|
| 317 | 0 | 45 | 5,893 | 253 | 532 |
| Protein | Taxonomy | rx 821002 (IC50) | yohimbine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 1.02 | |
| D(2) dopamine receptor | Homo sapiens (human) | 2.06 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0428 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0466 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.126 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0682 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.013 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.126 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.074 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 1.3 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 1.689 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.28) | 18.7374 |
| 1990's | 44 (72.13) | 18.2507 |
| 2000's | 12 (19.67) | 29.6817 |
| 2010's | 3 (4.92) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Denis-Pouxviel, C; Devedjian, JC; Esclapez, F; Paris, H | 1 |
| Neubig, RR; Porter, AC; Uhlén, S | 1 |
| Harms, GS; Lohse, MJ; Steinmeyer, R; Vilardaga, JP | 1 |
| Paris, H; Remaury, A | 1 |
| Leslie, FM; Raymon, HK; Smith, TD | 1 |
| Blaxall, HS; Bylund, DB; Lawhead, RG | 1 |
| Litthauer, D; Oelofsen, W; van de Venter, M | 1 |
| Uhlén, S; Wikberg, JE | 1 |
| Czerwiec, E; De Backer, JP; De Potter, W; De Vos, H; Vauquelin, G | 1 |
| Berlan, M; Galitzky, J; Montastruc, P; Tran, MA | 1 |
| Berlan, M; Galitzky, J; Lafontan, M; Larrouy, D | 1 |
| Lafontan, M; Langin, D; Paris, H | 1 |
| Carpéné, C; Galitzky, J; Lafontan, M; Langin, D; Larrouy, D | 1 |
| Berlan, M; Galitzky, J; Lafontan, M; Montastruc, JL; Senard, JM; Stillings, M | 1 |
| Berlan, M; Estan, L; Montastruc, JL; Senard, JM; Tran, MA | 1 |
| Lafontan, M; Langin, D; Paris, H; Stillings, MR | 1 |
| Carpéné, C; Lafontan, M; Langin, D; Saulnier-Blache, JS | 1 |
| Hussain, JF; Kendall, DA; Pinthong, D; Wilson, VG | 1 |
| Berlie, JR; Blaxall, HS; Bylund, DB; Chacko, DM; Cooley, ME; Iversen, LJ | 1 |
| Szabo, B; Urban, R | 1 |
| Blaylock, NA; Kendall, DA; Wilson, VG; Wright, IK | 1 |
| Halme, M; Savola, JM; Scheinin, M; Sjöholm, B | 1 |
| Erdbrügger, W; Michel, MC; Otto, T; Raulf, M | 1 |
| Evans, RG; Haynes, JM | 1 |
| Starke, K; Szabo, B; Urban, R | 1 |
| Blaxall, HS; Bylund, DB; Iversen, LJ; O'Rourke, MF | 1 |
| Ala-Uotila, S; Kurose, H; Marjamäki, A; Oker-Blom, C; Pohjanoksa, K; Scheinin, M; Sizmann, D | 1 |
| Bylund, DB; Iversen, LJ; Lomasney, JW; O'Rourke, MF | 1 |
| Berlan, M; Galitzky, J; Le Corre, P; Le Verge, R | 1 |
| Etgen, AM; Karkanias, GB | 1 |
| Clarke, RW; Harris, J | 1 |
| De Backer, JP; De Keyser, J; De Vos, H; Van Liefde, I; Vauquelin, G | 1 |
| Blandizzi, C; Carignani, D; Colucci, R; Crema, F; Del Tacca, M; Lazzeri, G; Natale, G | 1 |
| Savola, JM; Savola, MK | 1 |
| Bylund, DB; Cerutis, DR; Deupree, JD; Hinton, KA | 1 |
| Elliott, J | 1 |
| Goldstein, I; Huang, YH; Moreland, RB; Traish, AM | 1 |
| Akerman, KE; Cockcroft, V; Huifang, G; Jansson, CC; Kukkonen, JP; Savola, JM; Wurster, S | 1 |
| Dambrova, M; Gu, Y; Näsman, J; Schiöth, HB; Uhlén, S; Wikberg, JE; Wikberg-Matsson, A | 1 |
| Birdsall, NJ; Lazareno, S; Leppik, RA; Mynett, A | 1 |
| Bach, KB; Mitchell, GS | 1 |
| Cleale, RM; Hadcock, JR; Ingling, JM; Pausch, MH; Search, DJ | 1 |
| Audinot, V; Chaput, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Richard, N; Touzard, M; Verrièle, L | 1 |
| Caramona, MM; Figueiredo, IV; Guimarães, S; Moura, D; Paiva, MQ | 1 |
| Holmberg, M; Kurose, H; Miettinen, R; Scheinin, M | 1 |
| Hillilä, M; Lähdesmäki, J; Pyykkö, K; Scheinin, M; Sjöholm, B | 1 |
| McAllister, KH; Rey, B | 1 |
| Cockcroft, V; Frang, H; Marjamäki, A; Pihlavisto, M; Scheinin, M | 1 |
| Benamour, K; Chang-Fong, J; Cussac, M; Morand, JM; Szymonski, B; Thomasson, F | 1 |
| Bylund, DB; Gerety, ME; Happe, HK; Murrin, LC | 1 |
| Akerman, KE; Jansson, CC; Kukkonen, JP | 1 |
| McAllister, KH | 1 |
| De Luca, LA; Menani, JV; Moreira, Tdos S; Renzi, A; Takakura, AC | 1 |
| De Luca, LA; dos Santos Moreira, T; Menani, JV; Renzi, A; Takakura, AC | 1 |
| Fagerholm, V; Holmberg, M; Scheinin, M | 1 |
| Fagerholm, V; Hein, L; Philipp, M; Scheinin, M | 1 |
| Amano, T; Ebiko, M; Kimura, Y; Sakurada, S; Yonezawa, A; Yoshizumii, M | 1 |
| de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR | 1 |
| Arszol, C; Bartenstein, P; Böning, G; Cumming, P; Josef Gildehaus, F; Mille, E; Rominger, A; Wängler, B | 1 |
| Almeida, RL; Constancio, J; David, RB; De Luca, LA; Fracasso, JF; Menani, JV | 1 |
| Alves, TB; Antunes, VR; Colombari, E; Ferreira-Neto, HC; Menani, JV; Moreira, TS; Takakura, AC; Totola, LT | 1 |
61 other study(ies) available for rx 821002 and yohimbine
| Article | Year |
|---|---|
Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line; Dioxanes; Humans; Idazoxan; Plasmids; Radioligand Assay; Receptors, Adrenergic, alpha; Transfection | 1994 |
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; CHO Cells; Cricetinae; Dibenzazepines; Humans; Imidazoles; Indoles; Isoindoles; Quinolizines; Radioligand Assay; Receptors, Adrenergic, alpha-2 | 1994 |
Molecular basis of inverse agonism in a G protein-coupled receptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Cell Line; Fluorescence Resonance Energy Transfer; Humans; Ligands; Protein Binding; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Signal Transduction | 2005 |
The insulin-secreting cell line, RINm5F, expresses an alpha-2D adrenoceptor and nonadrenergic idazoxan-binding sites.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Cell Line; Cyclic AMP; Dioxanes; GTP-Binding Proteins; Idazoxan; Immunoblotting; Insulin; Insulin Secretion; Kinetics; Membranes; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Tritium; Virulence Factors, Bordetella; Yohimbine | 1992 |
Further pharmacological characterization of [3H]idazoxan binding sites in rat brain: evidence for predominant labeling of alpha 2-adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Buffers; Dioxanes; Epinephrine; Idazoxan; Male; Phentolamine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Drug; Tritium; Yohimbine | 1992 |
Alpha-2A is the predominant alpha-2 adrenergic receptor subtype in human spinal cord.
Topics: Adrenergic alpha-Antagonists; Dioxanes; Humans; Idazoxan; In Vitro Techniques; Indicators and Reagents; Receptors, Adrenergic, alpha; Spinal Cord; Yohimbine | 1992 |
The effect of high concentrations of alpha 2-adrenoceptor antagonists on the lipolytic responsiveness of isolated human adipocytes.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Dioxanes; Female; Humans; Idazoxan; Isoproterenol; Lipolysis; Norepinephrine; Propanolamines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Yohimbine | 1992 |
Delineation of three pharmacological subtypes of alpha 2-adrenoceptor in the rat kidney.
Topics: Animals; Binding, Competitive; Computer Simulation; Dioxanes; Guanabenz; Idazoxan; In Vitro Techniques; Kidney; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
[3H]rauwolscine behaves as an agonist for the 5-HT1A receptors in human frontal cortex membranes.
Topics: Adrenergic alpha-Antagonists; Aged; Dioxanes; Frontal Lobe; GTP-Binding Proteins; Guanine Nucleotides; Humans; Idazoxan; In Vitro Techniques; Kinetics; Membranes; Middle Aged; Mollusk Venoms; Phentolamine; Receptors, Adrenergic, alpha; Receptors, Serotonin; Yohimbine | 1991 |
Anorectic effect of alpha 2-antagonists in dog: effect of acute and chronic treatment.
Topics: Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Blood Glucose; Blood Platelets; Body Weight; Catecholamines; Cell Membrane; Dioxanes; Dogs; Fatty Acids, Nonesterified; Feeding Behavior; Idazoxan; Imidazoles; Insulin; Male; Nadolol; Yohimbine | 1991 |
New tools for human fat cell alpha-2A adrenoceptor characterization. Identification on membranes and on intact cells using the new antagonist [3H]RX821002.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adult; Dioxanes; Dioxins; Female; Guanosine Triphosphate; Humans; Idazoxan; In Vitro Techniques; Kinetics; Magnesium; Middle Aged; Receptors, Adrenergic, alpha; Tritium; Yohimbine | 1990 |
Binding of [3H]idazoxan and of its methoxy derivative [3H] RX821002 in human fat cells: [3H]idazoxan but not [3H] RX821002 labels additional non-alpha 2-adrenergic binding sites.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Binding Sites; Brimonidine Tartrate; Cell Membrane; Cystamine; Dioxanes; Dioxins; Epinephrine; Female; Humans; Idazoxan; Magnesium Chloride; Phenoxybenzamine; Potassium Chloride; Quinoxalines; Tritium; Yohimbine | 1990 |
Non-adrenergic sites for imidazolines are not directly involved in the alpha 2-adrenergic antilipolytic effect of UK 14304 in rat adipocytes.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Bucladesine; Cell Membrane; Colforsin; Dioxanes; Idazoxan; Kinetics; Lipolysis; Phentolamine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Identification of human platelet alpha 2-adrenoceptors with a new antagonist [3H]-RX821002, a 2-methoxy derivative of idazoxan.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Blood Platelets; Brimonidine Tartrate; Dioxanes; Epinephrine; Humans; Idazoxan; In Vitro Techniques; Kinetics; Male; Membranes; Oxymetazoline; Prazosin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Reserpine induces vascular alpha 2-adrenergic supersensitivity and platelet alpha 2-adrenoceptor up-regulation in dog.
Topics: Adipose Tissue; Animals; Blood Platelets; Blood Pressure; Cardiovascular System; Catecholamines; Cell Membrane; Clonidine; Dioxanes; Dogs; Heart Rate; Idazoxan; Male; Norepinephrine; Posture; Prazosin; Receptors, Adrenergic, alpha; Reserpine; Up-Regulation; Yohimbine | 1990 |
[3H]RX821002: a new tool for the identification of alpha 2A-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Binding, Competitive; Catecholamines; Cell Membrane; Colforsin; Cyclic AMP; Dioxanes; Dioxins; Humans; Idazoxan; Kinetics; Radioligand Assay; Receptors, Adrenergic, alpha; Tumor Cells, Cultured; Yohimbine | 1989 |
Imidazolinic radioligands for the identification of hamster adipocyte alpha 2-adrenoceptors.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cricetinae; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Kinetics; Lipid Metabolism; Lipolysis; Male; Mesocricetus; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Imidazoles; Lung; Methanol; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Yohimbine | 1995 |
Alpha-2 adrenergic receptors in the bovine retina. Presence of only the alpha-2D subtype.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Dioxanes; Idazoxan; Pineal Gland; Radioligand Assay; Receptors, Adrenergic, alpha-2; Retina; Yohimbine | 1995 |
Mechanism of sympathoinhibition by imidazolines.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzazepines; Brimonidine Tartrate; Dioxanes; Hemodynamics; Idazoxan; Imidazoles; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1995 |
The relationship between density of alpha-adrenoceptor binding sites and contractile responses in several porcine isolated blood vessels.
Topics: 5'-Nucleotidase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Cell Membrane; Dioxanes; Dose-Response Relationship, Drug; Drug Interactions; Ear, External; Idazoxan; Male; Microscopy, Electron; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha; Splenic Artery; Structure-Activity Relationship; Swine; Veins; Yohimbine | 1995 |
Recombinant human alpha 2-adrenoceptor subtypes: comparison of [3H]rauwolscine, [3H]atipamezole and [3H]RX821002 as radioligands.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding, Competitive; Buffers; Cell Line; Dioxanes; Humans; Idazoxan; Imidazoles; Kinetics; Mice; Radioligand Assay; Recombinant Proteins; Yohimbine | 1995 |
Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line; Dioxanes; Epinephrine; Female; Guinea Pigs; Humans; Idazoxan; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1995 |
Characterization of binding sites for [3H]-idazoxan, [3H]-P-aminoclonidine and [3H]-rauwolscine in the kidney of the dog.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Clonidine; Dioxanes; Dogs; GTP-Binding Proteins; Idazoxan; Imidazoline Receptors; Kidney; Male; Radioligand Assay; Receptors, Drug; Yohimbine | 1994 |
Sympathoinhibition by rilmenidine in conscious rabbits: involvement of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Catecholamines; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Female; Heart Rate; Hemodynamics; Idazoxan; Kidney; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1993 |
Characterization of [3H]RX821002 binding to alpha-2 adrenergic receptor subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Cattle; CHO Cells; Cricetinae; Dioxanes; Female; Idazoxan; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1994 |
Similar ligand binding in recombinant human alpha 2 C2-adrenoceptors produced in mammalian, insect and yeast cells.
Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Cells, Cultured; Chlorpromazine; Dioxanes; Humans; Idazoxan; Immunoblotting; Mammary Neoplasms, Experimental; Mice; Molecular Sequence Data; Moths; Oxymetazoline; Prazosin; Receptors, Adrenergic, alpha; Recombinant Proteins; Saccharomyces cerevisiae; Transfection; Tumor Cells, Cultured; Yohimbine | 1994 |
Species orthologs of the alpha-2A adrenergic receptor: the pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors.
Topics: Animals; Binding Sites; Cattle; Cell Line; Dioxanes; Humans; Idazoxan; Rats; Receptors, Adrenergic, alpha-2; Species Specificity; Swine; Yohimbine | 1994 |
Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Blood Platelets; Blood Proteins; Brimonidine Tartrate; Cell Membrane; Dioxanes; Epinephrine; Humans; Hydroxylation; Idazoxan; In Vitro Techniques; Lipolysis; Male; Platelet Aggregation; Protein Binding; Quinoxalines; Yohimbine | 1993 |
Estradiol attenuates alpha 2-adrenoceptor-mediated inhibition of hypothalamic norepinephrine release.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Dioxanes; Estradiol; Female; Hypothalamus; Idazoxan; Norepinephrine; Ovariectomy; Potassium Chloride; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Yohimbine | 1993 |
Motor and cardiovascular effects of selective alpha 2-adrenoceptor antagonists in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Decerebrate State; Dioxanes; Electric Stimulation; Female; Heart Rate; Idazoxan; Injections, Spinal; Male; Motor Neurons; Rabbits; Reflex; Retrospective Studies; Sural Nerve; Yohimbine | 1993 |
Alpha 2A adrenoceptors and non-adrenergic idazoxan binding sites in calf brain and retina are distinct from those in human brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cattle; Cell Membrane; Dioxanes; Frontal Lobe; Humans; Idazoxan; Receptors, Adrenergic, alpha; Retina; Species Specificity; Yohimbine | 1993 |
Determination on functional basis of presynaptic alpha 2-adrenoceptor subtypes in guinea-pig duodenum.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholinergic Fibers; Duodenum; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Male; Medetomidine; Muscle Contraction; Nordefrin; Norepinephrine; Oxymetazoline; Piperazines; Prazosin; Receptors, Adrenergic, alpha-2; Synaptic Membranes; Vasoconstrictor Agents; Xylazine; Yohimbine | 1996 |
alpha 2A/D-Adrenoceptor subtype predominates also in the neonatal rat spinal cord.
Topics: Adrenergic alpha-Agonists; Age Factors; Animals; Animals, Newborn; Female; Idazoxan; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Tritium; Yohimbine | 1996 |
Buffers differentially alter the binding of [3H]rauwolscine and [3H]RX821002 to the alpha-2 adrenergic receptor subtypes.
Topics: Animals; Buffers; CHO Cells; Cricetinae; Humans; Idazoxan; Kinetics; Opossums; Oxymetazoline; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Species Specificity; Yohimbine | 1996 |
Alpha-adrenoceptors in equine digital veins: evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Binding, Competitive; Brimonidine Tartrate; Dopamine; Horses; Idazoxan; In Vitro Techniques; Isometric Contraction; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction; Veins; Yohimbine | 1997 |
Expression of functional alpha2-adrenergic receptor subtypes in human corpus cavernosum and in cultured trabecular smooth muscle cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Cells, Cultured; Colforsin; Cyclic AMP; Humans; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Penis; Quinoxalines; Radioisotopes; Receptors, Adrenergic, alpha-2; Ribonucleases; RNA, Messenger; Yohimbine | 1997 |
Different apparent modes of inhibition of alpha2A-adrenoceptor by alpha2-adrenoceptor antagonists.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Humans; Idazoxan; Quinolizines; Receptors, Adrenergic, alpha-2; Tritium; Tumor Cells, Cultured; Yohimbine | 1997 |
[3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine.
Topics: Adrenergic Agents; Animals; Guinea Pigs; Humans; Idazoxan; Isoquinolines; Naphthyridines; Quinolizines; Rats; Receptors, Adrenergic, alpha-2; Swine; Yohimbine | 1998 |
Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor.
Topics: Adrenergic alpha-Antagonists; Allosteric Regulation; Amiloride; Animals; CHO Cells; Cricetinae; Humans; Idazoxan; Protein Binding; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1998 |
Hypercapnia-induced long-term depression of respiratory activity requires alpha2-adrenergic receptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbon Dioxide; Hypercapnia; Hypoglossal Nerve; Idazoxan; Male; Norepinephrine; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Respiratory Mechanics; Vagotomy; Yohimbine | 1998 |
Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: II. Nitrogen balance responses.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animal Feed; Animals; Digestion; Dose-Response Relationship, Drug; Ethanolamines; Idazoxan; Injections, Subcutaneous; Linear Models; Male; Nitrogen; Random Allocation; Swine; Yohimbine | 1998 |
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; CHO Cells; Cricetinae; Guanfacine; Humans; Idazoxan; Imidazoles; Ligands; Medetomidine; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Yohimbine | 1998 |
Prejunctional alpha2A-autoreceptors in the human gastric and ileocolic arteries.
Topics: Adrenergic alpha-Antagonists; Aged; Arteries; Autoreceptors; Colon; Dioxanes; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gastric Mucosa; Humans; Idazoxan; Ileum; In Vitro Techniques; Male; Middle Aged; Neuromuscular Junction; Norepinephrine; Phentolamine; Prazosin; Receptors, Adrenergic, alpha-2; Spiro Compounds; Stomach; Tritium; Yohimbine | 1998 |
Adrenergic alpha2C-receptors reside in rat striatal GABAergic projection neurons: comparison of radioligand binding and immunohistochemistry.
Topics: Adrenergic alpha-Antagonists; Animals; Antibodies; Autoradiography; Binding, Competitive; Brain Chemistry; Calbindin 1; Calbindin 2; Calbindins; Corpus Striatum; gamma-Aminobutyric Acid; Idazoxan; Immunohistochemistry; Male; Neurons; Norepinephrine; Parvalbumins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; S100 Calcium Binding Protein G; Tissue Fixation; Tritium; Yohimbine | 1999 |
Non-adrenergic binding of [3H]atipamezole in rat kidney--regional distribution and comparison to alpha2-adrenoceptors.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Female; Idazoxan; Imidazoles; Kidney; Male; Membranes; Monoamine Oxidase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1999 |
Clozapine reversal of the deficits in coordinated movement induced by D2 receptor blockade does not depend upon antagonism of alpha2 adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Ataxia; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Idazoxan; Loxapine; Male; Muscarinic Antagonists; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Scopolamine; Yohimbine | 1999 |
Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Cricetinae; Cysteine; Dopamine Antagonists; Humans; Idazoxan; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Oxymetazoline; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Serine; Transfection; Tritium; Yohimbine | 2000 |
Synthesis and alpha-adrenergic binding ligand affinities of 2-iminoimidazolidine derivatives.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; Idazoxan; Imidazoles; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Spectrophotometry, Infrared; Yohimbine | 2000 |
Inverse agonism at alpha(2)-adrenoceptors in native tissue.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Guanosine Triphosphate; Idazoxan; Kinetics; Protein Binding; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 2000 |
Agonist trafficking of G(i/o)-mediated alpha(2A)-adrenoceptor responses in HEL 92.1.7 cells.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Biological Transport; Calcium; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Idazoxan; Pertussis Toxin; Propranolol; Receptors, Adrenergic, alpha-2; Tumor Cells, Cultured; Virulence Factors, Bordetella; Yohimbine | 2001 |
The alpha 2 adrenoceptor antagonists RX 821002 and yohimbine delay-dependently impair choice accuracy in a delayed non-matching-to-position task in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Idazoxan; Male; Muscarinic Antagonists; Psychomotor Performance; Rats; Scopolamine; Yohimbine | 2001 |
Inhibition of pilocarpine-induced salivation in rats by central noradrenaline.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Idazoxan; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscarinic Agonists; Norepinephrine; Pilocarpine; Prazosin; Rats; Rats, Sprague-Dawley; Saliva; Salivation; Statistics as Topic; Yohimbine | 2002 |
Central alpha(2) adrenergic receptors and cholinergic-induced salivation in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Idazoxan; Imidazoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscarinic Agonists; Pilocarpine; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Salivation; Sympatholytics; Yohimbine | 2003 |
Regional distribution of alpha(2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the alpha(2C)-subtype: an autoradiographic study with [(3)H]RX821002 and [(3)H]rauwolscine.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Female; Idazoxan; Mice; Mice, Inbred Strains; Mice, Transgenic; Neurons; Norepinephrine; Radioligand Assay; Receptors, Adrenergic, alpha-2; Spinal Cord; Synaptic Transmission; Tritium; Up-Regulation; Yohimbine | 2003 |
[Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Autoradiography; Binding Sites; Binding, Competitive; Cerebral Cortex; Idazoxan; In Vitro Techniques; Isoquinolines; Ligands; Mice; Mice, Knockout; Naphthyridines; Oxymetazoline; Phentolamine; Prazosin; Putamen; Radioligand Assay; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 2004 |
Long-lasting effects of yohimbine on the ejaculatory function in male dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dogs; Ejaculation; Idazoxan; Male; Penile Erection; Sexual Behavior, Animal; Time Factors; Yohimbine | 2005 |
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Idazoxan; Imidazoles; Leucine; Male; Naloxone; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Wistar; Xylazine; Yohimbine | 2009 |
α2-adrenergic drugs modulate the binding of [18F]fallypride to dopamine D2/3 receptors in striatum of living mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzamides; Binding, Competitive; Brain Mapping; Clonidine; Corpus Striatum; Dopamine; Female; Idazoxan; Mice; Mice, Inbred BALB C; Positron-Emission Tomography; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Yohimbine | 2010 |
Inhibition of sodium appetite by lipopolysaccharide: involvement of alpha2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Appetite; Blood Pressure; Body Temperature; Dose-Response Relationship, Drug; Gastric Emptying; Heart Rate; Idazoxan; Injections, Intraperitoneal; Lipopolysaccharides; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sodium Chloride, Dietary; Yohimbine | 2011 |
Commissural nucleus of the solitary tract regulates the antihypertensive effects elicited by moxonidine.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Consciousness; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Injections; Injections, Intraventricular; Male; Neurons; Rats; Rats, Inbred SHR; Rats, Wistar; Solitary Nucleus; Stereotaxic Techniques; Yohimbine | 2013 |