rx 821002 has been researched along with oxymetazoline in 14 studies
| Studies (rx 821002) | Trials (rx 821002) | Recent Studies (post-2010) (rx 821002) | Studies (oxymetazoline) | Trials (oxymetazoline) | Recent Studies (post-2010) (oxymetazoline) |
|---|---|---|---|---|---|
| 317 | 0 | 45 | 738 | 128 | 159 |
| Protein | Taxonomy | rx 821002 (IC50) | oxymetazoline (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.578 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 3.261 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 1.332 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.023 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.2 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 1.273 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 2.633 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.0056 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 2.844 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 1.285 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.578 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.0056 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 3.056 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 1.67 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (64.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neubig, RR; Porter, AC; Uhlén, S | 1 |
| Harms, GS; Lohse, MJ; Steinmeyer, R; Vilardaga, JP | 1 |
| Alves, FR; Antonio, CB; Barreiro, EJ; Figueiredo, CD; Fraga, CA; Herzfeldt, V; Moura, BC; Noël, F; Pompeu, TE; Rates, SM | 1 |
| De Backer, JP; De Keyser, J; De Vos, H; Van Liefde, I; Vauquelin, G | 1 |
| Berlan, M; Galitzky, J; Lafontan, M; Montastruc, JL; Senard, JM; Stillings, M | 1 |
| Etgen, AM; Karkanias, GB | 1 |
| Ala-Uotila, S; Kurose, H; Marjamäki, A; Oker-Blom, C; Pohjanoksa, K; Scheinin, M; Sizmann, D | 1 |
| Blandizzi, C; Carignani, D; Colucci, R; Crema, F; Del Tacca, M; Lazzeri, G; Natale, G | 1 |
| Bylund, DB; Cerutis, DR; Deupree, JD; Hinton, KA | 1 |
| Flügge, G | 1 |
| Coupar, IM; Liu, L | 1 |
| Cockcroft, V; Frang, H; Marjamäki, A; Pihlavisto, M; Scheinin, M | 1 |
| Fagerholm, V; Hein, L; Philipp, M; Scheinin, M | 1 |
| Díez-Alarcia, R; Fernández-López, A; Meana, JJ; Paniagua, MA; Pilar-Cuéllar, F | 1 |
14 other study(ies) available for rx 821002 and oxymetazoline
| Article | Year |
|---|---|
The novel alpha-2 adrenergic radioligand [3H]-MK912 is alpha-2C selective among human alpha-2A, alpha-2B and alpha-2C adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; CHO Cells; Cricetinae; Dibenzazepines; Humans; Imidazoles; Indoles; Isoindoles; Quinolizines; Radioligand Assay; Receptors, Adrenergic, alpha-2 | 1994 |
Molecular basis of inverse agonism in a G protein-coupled receptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Cell Line; Fluorescence Resonance Energy Transfer; Humans; Ligands; Protein Binding; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Signal Transduction | 2005 |
Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Chemistry Techniques, Synthetic; Dose-Response Relationship, Drug; Drug Design; Locomotion; Male; Mice; Piperazines; Receptor, Serotonin, 5-HT2A; Schizophrenia | 2013 |
Regional distribution of alpha 2A- and alpha 2B-adrenoceptor subtypes in postmortem human brain.
Topics: Adrenergic alpha-Antagonists; Aged; Binding, Competitive; Brain; Cadaver; Dioxanes; Humans; Idazoxan; Middle Aged; Oxymetazoline; Prazosin; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tissue Distribution | 1992 |
Identification of human platelet alpha 2-adrenoceptors with a new antagonist [3H]-RX821002, a 2-methoxy derivative of idazoxan.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Blood Platelets; Brimonidine Tartrate; Dioxanes; Epinephrine; Humans; Idazoxan; In Vitro Techniques; Kinetics; Male; Membranes; Oxymetazoline; Prazosin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
A thermodynamic analysis of estrogen regulation of alpha 2-adrenoceptor binding.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Dioxanes; Estradiol; Female; Guanylyl Imidodiphosphate; Hypothalamus; Idazoxan; Ligands; Ovariectomy; Oxymetazoline; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Temperature; Thermodynamics | 1995 |
Similar ligand binding in recombinant human alpha 2 C2-adrenoceptors produced in mammalian, insect and yeast cells.
Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Cells, Cultured; Chlorpromazine; Dioxanes; Humans; Idazoxan; Immunoblotting; Mammary Neoplasms, Experimental; Mice; Molecular Sequence Data; Moths; Oxymetazoline; Prazosin; Receptors, Adrenergic, alpha; Recombinant Proteins; Saccharomyces cerevisiae; Transfection; Tumor Cells, Cultured; Yohimbine | 1994 |
Determination on functional basis of presynaptic alpha 2-adrenoceptor subtypes in guinea-pig duodenum.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholinergic Fibers; Duodenum; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Male; Medetomidine; Muscle Contraction; Nordefrin; Norepinephrine; Oxymetazoline; Piperazines; Prazosin; Receptors, Adrenergic, alpha-2; Synaptic Membranes; Vasoconstrictor Agents; Xylazine; Yohimbine | 1996 |
Buffers differentially alter the binding of [3H]rauwolscine and [3H]RX821002 to the alpha-2 adrenergic receptor subtypes.
Topics: Animals; Buffers; CHO Cells; Cricetinae; Humans; Idazoxan; Kinetics; Opossums; Oxymetazoline; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Species Specificity; Yohimbine | 1996 |
Alterations in the central nervous alpha 2-adrenoceptor system under chronic psychosocial stress.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Chronic Disease; Down-Regulation; Hydrocortisone; Idazoxan; Locus Coeruleus; Male; Nerve Tissue Proteins; Norepinephrine; Oxymetazoline; Pituitary-Adrenal System; Prefrontal Cortex; Quinoxalines; Receptors, Adrenergic, alpha-2; Social Dominance; Solitary Nucleus; Stress, Psychological; Tupaiidae; Up-Regulation; Vagus Nerve | 1996 |
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Clonidine; Electric Stimulation; Idazoxan; Ileum; In Vitro Techniques; Muscle Contraction; Oxymetazoline; Phentolamine; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Presynaptic | 1997 |
Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Cricetinae; Cysteine; Dopamine Antagonists; Humans; Idazoxan; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Oxymetazoline; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Serine; Transfection; Tritium; Yohimbine | 2000 |
[Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Autoradiography; Binding Sites; Binding, Competitive; Cerebral Cortex; Idazoxan; In Vitro Techniques; Isoquinolines; Ligands; Mice; Mice, Knockout; Naphthyridines; Oxymetazoline; Phentolamine; Prazosin; Putamen; Radioligand Assay; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 2004 |
Pharmacological characterization and autoradiographic distribution of alpha2-adrenoceptor antagonist [3H]RX 821002 binding sites in the chicken brain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Chickens; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; In Vitro Techniques; Male; Oxymetazoline; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin; Tritium | 2006 |