rx 821002 has been researched along with naloxone in 4 studies
| Studies (rx 821002) | Trials (rx 821002) | Recent Studies (post-2010) (rx 821002) | Studies (naloxone) | Trials (naloxone) | Recent Studies (post-2010) (naloxone) |
|---|---|---|---|---|---|
| 317 | 0 | 45 | 20,134 | 1,257 | 3,321 |
| Protein | Taxonomy | rx 821002 (IC50) | naloxone (IC50) |
|---|---|---|---|
| Cytochrome P450 2D6 | Homo sapiens (human) | 2 | |
| Delta-type opioid receptor | Mus musculus (house mouse) | 0.043 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0219 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.0019 | |
| Mu-type opioid receptor | Homo sapiens (human) | 0.0397 | |
| Delta-type opioid receptor | Homo sapiens (human) | 0.1896 | |
| Kappa-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.05 | |
| Kappa-type opioid receptor | Homo sapiens (human) | 0.0795 | |
| Mu-type opioid receptor | Mus musculus (house mouse) | 0.0154 | |
| Mu-type opioid receptor | Cavia porcellus (domestic guinea pig) | 0.0089 | |
| Beta-2 adrenergic receptor | Cavia porcellus (domestic guinea pig) | 0.0055 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gray, AM; Nevinson, MJ; Sewell, RD | 1 |
| Clarke, RW; Eves, S; Harris, J; Peachey, JE; Stuart, E | 1 |
| de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR | 1 |
| Berrocoso, E; Borges, GDS; Mico, JA; Torres-Sanchez, S | 1 |
4 other study(ies) available for rx 821002 and naloxone
| Article | Year |
|---|---|
The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception.
Topics: Abdominal Pain; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nefopam; Pain Measurement; Receptors, Adrenergic; Receptors, Opioid | 1999 |
Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Decerebrate State; Dexmedetomidine; Dizocilpine Maleate; Drug Synergism; Efferent Pathways; Electric Stimulation; Excitatory Amino Acid Antagonists; Idazoxan; Imidazoles; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Neurons, Afferent; Rabbits; Reflex; Skin; Sural Nerve; Tarsus, Animal | 2002 |
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Idazoxan; Imidazoles; Leucine; Male; Naloxone; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Wistar; Xylazine; Yohimbine | 2009 |
Opioid and noradrenergic contributions of tapentadol to the inhibition of locus coeruleus neurons in the streptozotocin rat model of polyneuropathic pain.
Topics: Action Potentials; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Idazoxan; Locus Coeruleus; Male; Naloxone; Neural Inhibition; Neurons; Pain Measurement; Rats; Tapentadol | 2018 |