rx 821002 has been researched along with idazoxan in 297 studies
| Studies (rx 821002) | Trials (rx 821002) | Recent Studies (post-2010) (rx 821002) | Studies (idazoxan) | Trials (idazoxan) | Recent Studies (post-2010) (idazoxan) |
|---|---|---|---|---|---|
| 317 | 0 | 45 | 1,499 | 40 | 123 |
| Protein | Taxonomy | rx 821002 (IC50) | idazoxan (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.0083 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0195 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0195 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0537 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0195 | |
| Alpha-1A adrenergic receptor | Homo sapiens (human) | 2.884 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0195 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (1.68) | 18.7374 |
| 1990's | 162 (54.55) | 18.2507 |
| 2000's | 93 (31.31) | 29.6817 |
| 2010's | 37 (12.46) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Butler, RC; Chapleo, CB; Davis, JA; Doxey, JC; England, CD; Myers, M; Myers, PL; Stillings, MR; Tweddle, N; Welbourn, AP | 1 |
| England, CD; Smith, CF; Stillings, MR; Welbourn, AP | 1 |
| Callado, LF; Meana, JJ; Ortega, JE; Rodriguez, F; Rozas, I | 1 |
| Callado, LF; Erdozain, AM; Meana, JJ; Ortega, JE; Rodriguez, F; Rozas, I | 2 |
| Cardinaletti, C; Carrieri, A; Farande, A; Gentili, F; Ghelfi, F; Giannella, M; Huhtinen, A; Laurila, JM; Piergentili, A; Pigini, M; Quaglia, W; Scheinin, M; Vesprini, C | 1 |
| Callado, LF; Erdozain, AM; Goonan, A; Kahvedzić, A; McCabe, T; Meana, JJ; Nagle, PS; Rodriguez, F; Rozas, I | 1 |
| Paris, H; Remaury, A | 1 |
| De Backer, JP; De Keyser, J; De Vos, H; Van Liefde, I; Vauquelin, G | 2 |
| Dieudonne, MN; Giudicelli, Y; Pecquery, R | 1 |
| Chhajlani, V; Uhlén, S; Wikberg, JE | 1 |
| Lafontan, M; Langin, D; Paris, H; Portillo, M | 1 |
| Hudson, AL; Mallard, NJ; Nutt, DJ | 1 |
| Leslie, FM; Raymon, HK; Smith, TD | 1 |
| Ahier, RG; Cremer, JE; Hudson, AL; Hume, SP; Lammertsma, AA; Myers, R; Nutt, DJ; Opacka-Juffry, J; Pike, VW | 1 |
| Blaxall, HS; Bylund, DB; Lawhead, RG | 1 |
| Litthauer, D; Oelofsen, W; van de Venter, M | 1 |
| Uhlén, S; Wikberg, JE | 3 |
| Daviaud, D; Denis-Pouxviel, C; Devedjian, JC; Fargues, M; Paris, H; Prats, H | 1 |
| Durcan, MJ; Linnoila, M; Lister, RG | 1 |
| Czerwiec, E; De Backer, JP; De Potter, W; De Vos, H; Vauquelin, G | 1 |
| Berlan, M; Galitzky, J; Montastruc, P; Tran, MA | 1 |
| Berlan, M; Langin, D; Montastruc, JL; Portillo, M; Reverte, M; Senard, JM; Tran, MA | 1 |
| Griffin, IJ; Jackson, HC; Nutt, DJ | 1 |
| Berlan, M; Galitzky, J; Lafontan, M; Larrouy, D | 1 |
| Atgie, C; Carpene, C; Lafontan, M; Quideau, N; Saulnier-Blache, JS | 1 |
| Lafontan, M; Langin, D; Paris, H | 1 |
| Dauzats, M; Lafontan, M; Langin, D; Paris, H | 1 |
| Carpéné, C; Galitzky, J; Lafontan, M; Langin, D; Larrouy, D | 1 |
| Carpéné, C; Dauzats, M; Lafontan, M; Larrouy, D; Quideau, N; Saulnier-Blache, JS | 1 |
| Daviaud, D; Laburthe, M; Langin, D; Paris, H; Remaury, A; Rouyer-Fessard, C; Voisin, T | 1 |
| Berlan, M; Galitzky, J; Lafontan, M; Montastruc, JL; Senard, JM; Stillings, M | 1 |
| Estan, L; Langin, D; Paris, H; Senard, JM | 1 |
| Carpéné, C; Guichard, C; Lafontan, M; Lavau, M; Rebourcet, MC | 1 |
| Berlan, M; Estan, L; Montastruc, JL; Senard, JM; Tran, MA | 1 |
| Doherty, TJ; Tweedie, DP | 1 |
| Lafontan, M; Langin, D; Paris, H; Stillings, MR | 1 |
| Carpéné, C; Lafontan, M; Langin, D; Saulnier-Blache, JS | 1 |
| Buckett, WR; Butler, SA; Cheetham, SC; Gosden, J; Heal, DJ; Prow, MR | 1 |
| Head, GA; Sannajust, F | 2 |
| Advenier, C; Biyah, K | 1 |
| Hussain, JF; Kendall, DA; Pinthong, D; Wilson, VG | 1 |
| Alemany, R; Escribá, PV; García-Sevilla, JA; Menargues, A; Obach, R; Olmos, G | 1 |
| Bouloumie, A; Galitzky, J; Lafontan, M; Langin, D; Remaury, A; Tavernier, G; Valet, P | 1 |
| Goodwin, WB; Guyenet, PG; Huangfu, D | 1 |
| Berlie, JR; Blaxall, HS; Bylund, DB; Chacko, DM; Cooley, ME; Iversen, LJ | 1 |
| Brown, CA; Chan, SL; Morgan, NG; Scarpello, KE | 2 |
| Goiny, M; Herrera-Marschitz, M; Meana, JJ | 1 |
| Szabo, B; Urban, R | 1 |
| Blaylock, NA; Kendall, DA; Wilson, VG; Wright, IK | 1 |
| Halme, M; Savola, JM; Scheinin, M; Sjöholm, B | 1 |
| Etgen, AM; Karkanias, GB | 3 |
| Erdbrügger, W; Michel, MC; Otto, T; Raulf, M | 1 |
| Evans, RG; Haynes, JM | 1 |
| Escribá, PV; García-Sevilla, JA; Regunathan, S; Reis, DJ; Sastre, M; Wang, H | 1 |
| Cloix, JF; Dausse, JP; Dieudonne, MN; Giudicelli, Y; Leneveu, MC; Pecquery, R | 1 |
| Bouloumié, A; Daviaud, D; Lafontan, M; Prats, H; Saulnier-Blache, JS; Valet, P | 1 |
| Carpéné, C; Collon, P; Cordi, A; Hudson, A; Lafontan, M; Nutt, D; Remaury, A | 1 |
| Atrens, DM; Fleischhauer, AE; Kuhlman, SJ; Siviy, SM | 1 |
| García-Sevilla, JA; Garro, MA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L | 1 |
| Musgrave, IF; Seifert, R | 1 |
| Starke, K; Szabo, B; Urban, R | 1 |
| Blaxall, HS; Bylund, DB; Iversen, LJ; O'Rourke, MF | 1 |
| Denis-Pouxviel, C; Devedjian, JC; Esclapez, F; Paris, H | 1 |
| Ala-Uotila, S; Kurose, H; Marjamäki, A; Oker-Blom, C; Pohjanoksa, K; Scheinin, M; Sizmann, D | 1 |
| García-Sevilla, JA; Sastre, M | 4 |
| Delima, EC; Rietkerk, FE | 1 |
| Durcan, MJ; Linnoila, M; Morgan, PF; Van Etten, ML | 1 |
| Muskardin, DT; Wallace, DR; Zahniser, NR | 1 |
| Millan, MJ; Renouard, A; Widdowson, PS | 1 |
| Bylund, DB; Iversen, LJ; Lomasney, JW; O'Rourke, MF | 1 |
| Bouloumié, A; Devedjian, JC; Lafontan, M; Planat, V; Record, M; Saulnier-Blache, JS; Valet, P | 1 |
| de Laveleye, F; Gobert, J; Noyer, M; Vauquelin, G; Wülfert, E | 1 |
| Falkay, G; Kovács, L; Melis, K | 1 |
| Barturen, F; Garcia-Sevilla, JA; Martin, I; Miralles, A; Olmos, G; Sastre, M | 1 |
| Chhajlani, V; Lien, EJ; Uhlén, S; Wikberg, JE; Xia, Y | 1 |
| Berlan, M; Galitzky, J; Le Corre, P; Le Verge, R | 1 |
| Couvineau, A; Daviaud, D; Denis, C; Devedjian, JC; Drean, G; Planat, V; Salomon, R; Senard, JM; Valet, P; Voisin, T | 1 |
| Daviaud, D; Larrouy, D; Paris, H; Remaury, A; Rouot, B | 1 |
| Asier Garro, M; García-Sevilla, JA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L | 1 |
| Clarke, RW; Harris, J | 2 |
| García-Sevilla, JA; Miralles, A; Ribas, C | 1 |
| García-Sevilla, JA; Miralles, A; Olmos, G; Ribas, C | 1 |
| Brown, CA; Morgan, NG | 1 |
| Lee, A; Lynch, KR; Rosin, DL; Talley, E | 1 |
| Anderson, WP; Evans, RG | 1 |
| Uhlén, S; Wikberg, JE; Wikberg-Matsson, A | 1 |
| Starke, K; Trendelenburg, AU; Wahl, CA | 1 |
| Blandizzi, C; Carignani, D; Colucci, R; Crema, F; Del Tacca, M; Lazzeri, G; Natale, G | 1 |
| Castan, I; Devedjian, JC; Lafontan, M; Paris, H; Valet, P | 1 |
| Savola, JM; Savola, MK | 1 |
| Chan, CK; Head, GA | 1 |
| Bylund, DB; Cerutis, DR; Deupree, JD; Hinton, KA | 1 |
| Houghton, AK; Westlund, KN | 1 |
| Callado, LF; García-Sevilla, JA; Grijalba, B; Javier Meana, J; Pazos, A | 1 |
| Flügge, G | 2 |
| Herman, CA; Luczy, G; Uhlén, S; Wikberg, JE | 1 |
| Callado, LF; Gabilondo, AM; Meana, JJ | 2 |
| Barsh, GS; Haapalinna, A; Kobilka, BK; Kulatunga, M; Leino, T; Link, RE; Macdonald, E; Pelto-Huikko, M; Sallinen, J; Scheinin, M; Sjöholm, B; Viitamaa, T | 1 |
| Bouysset, F; Laubie, M; Vayssettes-Courchay, C; Verbeuren, TJ | 1 |
| Conway, EL; Craven, JA | 1 |
| Intengan, HD; Smyth, DD | 1 |
| Czerwiec, E; De Backer, JP; Flamez, A; Ladure, P; Vauquelin, G | 1 |
| Autissier, N; Beltramo, JL; Ben Cheikh, R; Chomard, P; Dumas, P | 1 |
| Bylund, DB; Chacko, DM; Iversen, LJ; Matulka, WJ | 1 |
| Bétuing, S; Daviaud, D; Hickson, G; Lafontan, M; Lapalu, S; Peyroulan, D; Saulnier-Blache, JS; Valet, P | 1 |
| Bol, CJ; Danhof, M; IJzerman, AP; Mandema, JW | 1 |
| Coupar, IM; Liu, L | 1 |
| Elliott, J | 1 |
| Bearham, MC; Heal, DJ; Hutchins, LJ; Jackson, HC; Mazurkiewicz, SE; Needham, AM | 1 |
| Goldstein, I; Huang, YH; Moreland, RB; Traish, AM | 1 |
| Callado, LF; Meana, JJ | 1 |
| Etgen, AM; Karkanias, GB; Li, CS | 1 |
| Jansson, CC; Luomala, K; Marjamäki, A; Pohjanoksa, K; Savola, JM; Scheinin, M | 1 |
| Akerman, KE; Cockcroft, V; Huifang, G; Jansson, CC; Kukkonen, JP; Savola, JM; Wurster, S | 1 |
| Guyenet, PG; Huangfu, D | 1 |
| Correze, C; Dib, K; el Jamali, A; Lambert, B; Wrisez, F | 1 |
| Butterworth, RF; Buu, PN; Michalak, A; Rose, C | 1 |
| Callado, LF; García-Sevilla, JA; Grijalba, B; Meana, JJ; Pazos, A; Sastre, M | 1 |
| Barbe, P; Daviaud, D; Jeanneton, O; Lafontan, M; Pagès, C; Record, M; Saulnier-Blache, JS; Valet, P | 1 |
| Audinot, V; Cistarelli, L; Gobert, A; Millan, MJ; Newman-Tancredi, A; Rivet, JM | 1 |
| Chan, SL; Morgan, NG; Scarpello, KE | 1 |
| Dambrova, M; Gu, Y; Näsman, J; Schiöth, HB; Uhlén, S; Wikberg, JE; Wikberg-Matsson, A | 1 |
| Clarke, RW; Ogilvie, J | 1 |
| Bachman, GL; Herman, CA; Uhlén, S | 1 |
| Birdsall, NJ; Lazareno, S; Leppik, RA; Mynett, A | 1 |
| Bach, KB; Mitchell, GS | 1 |
| Bagaméry, K; Falkay, G; Kovács, L; Nyári, T | 1 |
| Coles, SK; Dick, TE; Ernsberger, P | 1 |
| Mateo, Y; Meana, JJ; Pineda, J | 1 |
| Cleale, RM; Hadcock, JR; Ingling, JM; Pausch, MH; Search, DJ | 2 |
| Escribá, PV; García-Sevilla, JA; Miralles, A; Ribas, C | 1 |
| Audinot, V; Chaput, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Richard, N; Touzard, M; Verrièle, L | 1 |
| Caramona, MM; Figueiredo, IV; Guimarães, S; Moura, D; Paiva, MQ | 1 |
| Baertschi, AJ; Grubb, MC; Guyenet, PG; Pence, R; Stornetta, RL | 1 |
| Dambrova, M; Oliver, DW; Tiger, G; Uhlén, S; Wikberg, JE | 1 |
| Pihlavisto, M; Scheinin, M; Sjöholm, B; Wurster, S | 1 |
| Clarke, RW; Houghton, AK; Ogilvie, J; Parry-Baggott, C | 1 |
| Gray, AM; Nevinson, MJ; Sewell, RD | 1 |
| Cayla, C; Gales, C; Paris, H; Quinchon, F; Roquelaine, C; Schaak, S | 1 |
| Colpaert, FC; Pauwels, PJ; Wurch, T | 1 |
| Aicher, SA; Drake, CT | 1 |
| Farley, JT; Klimek, V; Ordway, GA; Zhang, W; Zhu, MY | 1 |
| Clarke, RW; Ogilvie, J; Simpson, DA | 1 |
| da Silva, DC; de Andrade, CA; De Luca, LA; Haikel, L; Menani, JV; Renzi, A; Sato, MA; Vieira, AA | 1 |
| Assumpció Boronat, M; DeGregorio-Rocasolano, N; García-Sevilla, JA; Gasull, T; Lerma, J; Olmos, G; Paz Regalado, M; Trullas, R; Villarroel, A | 1 |
| Bylund, DB; Chacko, DM | 1 |
| Heal, DJ; Hughes, ZA; Stanford, SC; Wortley, KE | 1 |
| Mateo, Y; Meana, JJ | 1 |
| Holmberg, M; Kurose, H; Miettinen, R; Scheinin, M | 1 |
| Hall, L; Hudson, AL; Jackson, HC; Nutt, DJ; Robinson, ES | 1 |
| Heal, DJ; Stanford, SC; Wortley, KE | 1 |
| Goepel, M; Krege, S; Michel, MC; Michelotti, GA; Price, DT; Schwinn, DA | 1 |
| Kallio, J; Olli-Lähdesmäki, T; Scheinin, M | 1 |
| Ashcroft, FM; Bataille, D; Godfroid, JJ; Gribble, FM; Guardiola-Lemaître, B; Le Brigand, L; Manechez, D; Virsolvy, A | 1 |
| Hillilä, M; Lähdesmäki, J; Pyykkö, K; Scheinin, M; Sjöholm, B | 1 |
| McAllister, KH; Rey, B | 1 |
| Fukazawa, H; Ishida, H; Koda, H; Kuriyama, K; Matsumoto, N; Nukaya, H; Suwa, Y; Tsuji, K; Yokoo, Y | 1 |
| Clarke, RW; Ward, RE | 1 |
| Cockcroft, V; Frang, H; Marjamäki, A; Pihlavisto, M; Scheinin, M | 1 |
| Gentili, F; Massi, M; Panocka, I; Pigini, M; Polidori, C; Quaglia, W | 1 |
| Benamour, K; Chang-Fong, J; Cussac, M; Morand, JM; Szymonski, B; Thomasson, F | 1 |
| Bylund, DB; Gerety, ME; Happe, HK; Murrin, LC | 2 |
| Bylund, DB; Happe, HK; Murrin, LC | 1 |
| Colpaert, FC; Finana, F; Pauwels, PJ; Tardif, S; Wurch, T | 1 |
| Clarke, RW; Harris, J; Ogilvie, J | 1 |
| Baliko, CN; Siviy, SM | 1 |
| Bosch, F; Casellas, A; Cayla, C; Devedjian, JC; George, M; Paris, H; Pujol, A | 1 |
| Hudson, AL; Jackson, HC; Lalies, MD; Nutt, DJ; Robinson, ES; Tyacke, RJ | 1 |
| Colpaert, FC; Pauwels, PJ | 1 |
| Lan, K; Moore, DJ; Neubig, RR; Wade, SM | 1 |
| Bernini, M; Gobbi, M; Mennini, T; Parini, S; Pirona, L; Sacchetti, G; Samanin, R | 1 |
| Busquets, X; García-Sevilla, JA; Miralles, A; Ribas, C | 1 |
| Akerman, KE; Jansson, CC; Kukkonen, JP | 1 |
| Bisgard, GE; Herman, JK; O'Halloran, KD | 1 |
| Ansonoff, MA; Etgen, AM | 1 |
| Ashton, D; Hieble, JP; Naselsky, DP; Ruffolo, RR | 1 |
| Flügge, G; Fuchs, E; Kramer, M | 1 |
| McAllister, KH | 1 |
| Abdel-Rahman, AA; El-Mas, MM | 1 |
| Dausse, JP; Giudicelli, Y; Ilhami, N; Khalid, M | 1 |
| Berlan, M; Crampes, F; Daviaud, D; Gesta, S; Hejnova, J; Saulnier-Blache, JS; Stich, V; Valet, P | 1 |
| Bousquet, P; Brasili, L; Caretto, M; Carrieri, A; Dontenwill, M; Gentili, F; Giannella, M; Marucci, G; Perfumi, M; Piergentili, A; Pigini, M; Quaglia, W; Rascente, C | 1 |
| Corrêa, FM; Peres-Polon, VL; Tavares, RF | 1 |
| Ball, GF; Eens, M; Pinxten, R; Riters, LV | 1 |
| Cussac, D; Denis, C; Flordellis, C; Gales, C; Paris, H; Schaak, S | 1 |
| Banes, AJ; Faber, JE; Facemire, CS; Zhang, H | 1 |
| Fernández-Pastor, B; Meana, JJ | 1 |
| Finn, DP; Harbuz, MS; Hudson, AL; Jessop, DS; Lalies, MD; Nutt, DJ | 1 |
| Clarke, RW; Eves, S; Harris, J; Peachey, JE; Stuart, E | 1 |
| De Luca, LA; Menani, JV; Moreira, Tdos S; Renzi, A; Takakura, AC | 1 |
| Pauwels, PJ; Tardif, S | 1 |
| Erami, C; Faber, JE; French, DM; Ho, JG; Zhang, H | 1 |
| Goldstein, I; Huang, YH; Kim, NN; Min, K; Traish, AM | 1 |
| Bouysset, F; Cordi, A; Laubie, M; Vayssettes-Courchay, C; Verbeuren, TJ | 1 |
| Akerman, KE; Holmqvist, T; Kukkonen, JP; Näsman, J | 1 |
| De Luca, LA; dos Santos Moreira, T; Menani, JV; Renzi, A; Takakura, AC | 1 |
| Godwin, SJ; Head, GA; Parkin, ML | 1 |
| Cistarelli, L; Di Cara, B; Gobert, A; Millan, MJ | 1 |
| Fagerholm, V; Holmberg, M; Scheinin, M | 1 |
| Antunes-Rodrigues, J; Corrêa, FM; Crippa, GE; Fernandes, KB; Tavares, RF | 1 |
| Ge, H; Kallio, J; Scheinin, M | 1 |
| Dean, B | 1 |
| Kindlundh, A; Lindblom, J; Mugisha, P; Nyberg, F; Uhlén, S | 1 |
| Cole, DJ; Franklin, GL; Kim, JM; Mawhinney, MG | 1 |
| Hoffrén, AM; Johnson, MS; Kanerva, L; Marjamäki, A; Nyrönen, T; Peltonen, JM; Pihlavisto, M; Savola, JM; Scheinin, M; Wurster, S; Xhaard, H | 1 |
| Bylund, DB; Coulter, CL; Gerety, ME; Happe, HK; Murrin, LC; O'Rourke, M; Sanders, JD | 1 |
| Coventry, TL; Finn, DP; Harbuz, MS; Hudson, AL; Jessop, DS; Kinoshita, H; Nutt, DJ | 1 |
| Dziedzicka-Wasylewska, M; Faron-Górecka, A; Inan, SY; Kuśmider, M; Siwanowicz, J | 1 |
| Schmidt, WJ; Srinivasan, J | 2 |
| Fagerholm, V; Hein, L; Philipp, M; Scheinin, M | 1 |
| Bannova, AV; Dygalo, NN; Kalinina, TS; Shishkina, GT | 1 |
| Andrade, CA; Barbosa, SP; De Luca, LA; Menani, JV | 1 |
| Dygalo, NN; Kalinina, TS; Shishkina, GT | 1 |
| Hudson, AL; Hume, SP; Lalies, MD; Nutt, DJ; Robinson, ES; Tyacke, RJ | 1 |
| Dygalo, NN; Kalinina, TS; Popova, NK; Shishkina, GT | 1 |
| Flügge, G; Heilbronner, U; van Kampen, M | 1 |
| Herpfer, I; Hunt, SP; Stanford, SC | 1 |
| Corrêa, FM; Fernandes, KB; Resstel, LB | 1 |
| Blum, JW; Hammon, HM; Ontsouka, EC; Zbinden, Y | 1 |
| Amano, T; Ebiko, M; Kimura, Y; Sakurada, S; Yonezawa, A; Yoshizumii, M | 1 |
| Greenup, JL; Leverenz, JB; Peskind, ER; Raskind, MA; Szot, P; White, SS | 2 |
| Bönisch, H; Brüss, M; Caron, MG; Dziedzicka-Wasylewska, M; Faron-Górecka, A; Gilsbach, R; Rogóz, Z | 1 |
| Ahsan, MR; Lehmann, ML; Quartermain, D; Stone, EA; Yan, L; Yeretsian, J | 1 |
| Booze, RM; Mactutus, CF; Silvers, JM; Snow, DM; Strupp, BJ; Wallace, DR | 1 |
| Díez-Alarcia, R; Fernández-López, A; Meana, JJ; Paniagua, MA; Pilar-Cuéllar, F | 1 |
| Bylund, DB; Happe, HK; Murrin, LC; Sanders, JD; Szot, P; Weinshenker, D | 1 |
| Andrade, CA; Colombari, DS; De Luca, LA; Menani, JV | 1 |
| He, JX; Little, SP; Nelson, DL; Rocco, VP; Tu, Y; Wainscott, DB; Yin, T | 1 |
| Blum, JW; Meylan, M; Ontsouka, EC; Steiner, A | 1 |
| Burke, SL; Chan, CK; Head, GA | 1 |
| Angst, MJ; Fresquet, N; Gobaille, S; Sandner, G; Schleef, C | 1 |
| Fisher, AS; Hunt, SP; Stanford, SC; Stewart, RJ; Yan, T | 1 |
| Ball, GF; Castelino, CB; Cornil, CA | 1 |
| Alves, FH; Corrêa, FM; Crestani, CC; Tavares, RF | 1 |
| Ball, GF; Cornil, CA | 1 |
| Bylund, DB; Happe, HK; Murrin, LC; Sanders, JD | 1 |
| Colombari, DS; De Luca, LA; Menani, JV; Moreira, TS; Takakura, AC | 1 |
| de Castro Perez, A; de Francischi, JN; Gama Duarte, ID; Romero, TR | 1 |
| Bai, A; Chen, J; Guo, Y; Liu, Z; Lu, N | 1 |
| Chang, ST; Chuang, CH; Kao, YC; Lin, YL; Liu, YP; Tung, CS | 1 |
| Alves, FH; Correa, FM; Crestani, CC; Resstel, LB | 3 |
| Barbosa, SP; Colombari, DS; de Luca, LA; de Paula, PM; Gasparini, S; Menani, JV | 1 |
| Arszol, C; Bartenstein, P; Böning, G; Cumming, P; Josef Gildehaus, F; Mille, E; Rominger, A; Wängler, B | 1 |
| Acheson, AG; Dashwood, MR; Eames, T; Gruss, H; Henry, Y; Rayment, SJ; Scholefield, JH; Simpson, JA; Wilson, VG | 1 |
| Artigas, F; Bortolozzi, A; Masana, M | 1 |
| Bennett, DJ; D'Amico, J; Gorassini, MA; Murray, KC; Rank, MM; Stephens, MJ | 1 |
| Almeida, RL; Constancio, J; David, RB; De Luca, LA; Fracasso, JF; Menani, JV | 1 |
| Alba-Delgado, C; Berrocoso, E; Borges, G; Horrillo, I; Meana, JJ; Mico, JA; Neto, F; Ortega, JE; Sánchez-Blázquez, P | 1 |
| Alves, FH; Correa, FM; Crestani, CC; Resstel, LB; Scopinho, AA | 1 |
| Andrade, CA; Andrade-Franzé, GM; Antunes-Rodrigues, J; De Luca, LA; Margatho, LO; Menani, JV | 1 |
| Jahnsen, JA; Uhlén, S | 1 |
| Côrrea, FM; Crestani, CC; Fabri, DR; Gomes, FV; Hott, SC; Reis, DG; Resstel, LB | 1 |
| de Aguiar Corrêa, FM; Fortaleza, EA; Scopinho, AA | 1 |
| Aono, Y; Cools, AR; Koshikawa, N; Saigusa, T; Takada, K; Uchida, T; Verheij, MM | 1 |
| Galizzi, JP; Lockhart, B; Millan, MJ; Rivet, JM; Rodriguez, M; Serres, F; Sharp, T | 1 |
| Alba-Delgado, C; Berrocoso, E; Llorca-Torralba, M; Mico, JA; Torres-Sanchez, S | 1 |
| Alves, TB; Antunes, VR; Colombari, E; Ferreira-Neto, HC; Menani, JV; Moreira, TS; Takakura, AC; Totola, LT | 1 |
| Achterberg, EJ; Schoffelmeer, AN; Schrama, L; Siviy, SM; Trezza, V; Vanderschuren, LJ | 1 |
| Álvarez de La Rosa, D; Arce-Franco, M; Armas-González, E; Barreiro, O; Díaz-González, F; Domínguez-Luis, MJ; Feria, M; Herrera-García, AM; Machado, JD; Pec, MK; Sánchez-Madrid, F | 1 |
| Boblewski, K; Kornicka, A; Lehmann, A; Rybczyńska, A; Sączewski, F | 1 |
| Doudet, DJ; Fontain, J; Iversen, P; Landau, AM; Lillethorup, TP; Wegener, G | 1 |
| Doudet, DJ; Iversen, P; Landau, AM; Lillethorup, TP; Wegener, G | 1 |
| Beveridge, TJ; Nader, MA; Porrino, LJ; Smith, HR | 1 |
| Aalderink, M; Achterberg, EJ; Driel, NV; Houwing, DJ; Servadio, M; Trezza, V; van Kerkhof, LW; van Swieten, MM; Vanderschuren, LJ | 1 |
| Hackett, D; Heal, DJ; Hutson, PH; Murray, F; Vickers, SP | 1 |
| Khisamieva, LI; Zefirov, AL; Zefirov, TL; Ziyatdinova, NI | 2 |
| Essali, N; Sanders, J | 1 |
| Boblewski, K; Kornicka, A; Lehmann, A; Marchwińska, A; Rybczyńska, A; Sączewski, F; Sączewski, J | 1 |
| García-Fuster, MJ; García-Sevilla, JA | 1 |
| Jahnsen, JA; Schiöth, HB; Uhlén, S | 1 |
| Dobrzański, G; Kwiatkowska, K; Pradel, K; Przewłocki, R; Solecki, WB; Szklarczyk, K | 1 |
| Asaoka, Y; Kamii, H; Kaneda, K; Minami, M; Shinohara, F | 1 |
| Achterberg, EJM; Damsteegt, R; Vanderschuren, LJMJ | 1 |
| Berrocoso, E; Borges, GDS; Mico, JA; Torres-Sanchez, S | 1 |
| Nakamoto, M; Ohya, Y; Sakima, A; Takishita, S; Yamazato, M; Yamazato, Y | 1 |
| Hartzler, LK; Santin, JM; Vallejo, M | 1 |
1 review(s) available for rx 821002 and idazoxan
| Article | Year |
|---|---|
RX 821002 as a tool for physiological investigation of alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Brain; Idazoxan; Imidazoline Receptors; Norepinephrine; Pain Measurement; Rabbits; Rats; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Spinal Cord | 2002 |
296 other study(ies) available for rx 821002 and idazoxan
| Article | Year |
|---|---|
Alpha-adrenoreceptor reagents. 3. Synthesis of some 2-substituted 1,4-benzodioxans as selective presynaptic alpha 2-adrenoreceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dioxins; Idazoxan; In Vitro Techniques; Male; Mice; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Synapses; Vas Deferens | 1985 |
Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Dioxins; Imidazoles; Male; Mice; Muscle Contraction; Phenylephrine; Piperidines; Piperoxan; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Structure-Activity Relationship | 1986 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha(2)-adrenoceptor antagonists, 1: toward new antidepressants with heteroatomic linkers.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Binding, Competitive; Blood-Brain Barrier; Brain; Guanidines; Humans; Imidazolines; In Vitro Techniques; Male; Microdialysis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2007 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor antagonists. 2. Exploring alkyl linkers for new antidepressants.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents; Blood-Brain Barrier; Brain; Guanidines; Humans; Imidazoles; Imidazolines; In Vitro Techniques; Male; Microdialysis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stilbenes; Structure-Activity Relationship; Tetrahydronaphthalenes | 2008 |
Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; CHO Cells; Cricetinae; Cricetulus; Magnetic Resonance Spectroscopy; Mice; Rats; Receptors, Adrenergic, alpha-2 | 2008 |
Novel synthesis and pharmacological evaluation as alpha2-adrenoceptor ligands of O-phenylisouronium salts.
Topics: Adrenergic alpha-2 Receptor Antagonists; Antidepressive Agents; Brain; Crystallography, X-Ray; Drug Evaluation, Preclinical; Humans; Ligands; Models, Molecular; Molecular Structure; Salts; Stereoisomerism; Structure-Activity Relationship; Sulfides; Urea | 2008 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Microdialysis; Neurons; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 2009 |
The insulin-secreting cell line, RINm5F, expresses an alpha-2D adrenoceptor and nonadrenergic idazoxan-binding sites.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Cell Line; Cyclic AMP; Dioxanes; GTP-Binding Proteins; Idazoxan; Immunoblotting; Insulin; Insulin Secretion; Kinetics; Membranes; Pertussis Toxin; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Tritium; Virulence Factors, Bordetella; Yohimbine | 1992 |
Regional distribution of alpha 2A- and alpha 2B-adrenoceptor subtypes in postmortem human brain.
Topics: Adrenergic alpha-Antagonists; Aged; Binding, Competitive; Brain; Cadaver; Dioxanes; Humans; Idazoxan; Middle Aged; Oxymetazoline; Prazosin; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Tissue Distribution | 1992 |
Characteristics of the alpha 2/beta-adrenoceptor-coupled adenylate cyclase system and their relationship with adrenergic responsiveness in hamster fat cells from different anatomical sites.
Topics: Adenylyl Cyclases; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Colforsin; Cricetinae; Dioxanes; Epididymis; Epinephrine; GTP-Binding Proteins; Idazoxan; Isoproterenol; Kinetics; Lipolysis; Macromolecular Substances; Male; Mesocricetus; Organ Specificity; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Skin; Theophylline | 1992 |
Evidence that drug binding to non-adrenergic [3H]-idazoxan binding sites (I-receptors) occurs to interacting or interconvertible affinity forms of the receptor.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Computer Simulation; Dioxanes; Drug Interactions; Guinea Pigs; Idazoxan; Kidney; Male; Receptors, Adrenergic, alpha; Receptors, Drug | 1992 |
Imidazoline binding sites in fat cells. Localization and pharmacologic differentiation from alpha 2-adrenergic receptors.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Binding Sites; Cell Fractionation; Cell Membrane; Dioxanes; Female; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Mitochondria; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Time Factors; Tritium | 1992 |
Characterization and autoradiographical localization of non-adrenoceptor idazoxan binding sites in the rat brain.
Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Binding Sites; Brain; Dioxanes; Idazoxan; In Vitro Techniques; Male; Radiography; Radioligand Assay; Rats; Rats, Inbred Strains | 1992 |
Further pharmacological characterization of [3H]idazoxan binding sites in rat brain: evidence for predominant labeling of alpha 2-adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Buffers; Dioxanes; Epinephrine; Idazoxan; Male; Phentolamine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Drug; Tritium; Yohimbine | 1992 |
Quantification of in vivo binding of [3H]RX 821002 in rat brain: evaluation as a radioligand for central alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Dioxanes; Idazoxan; In Vitro Techniques; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tritium | 1992 |
Alpha-2A is the predominant alpha-2 adrenergic receptor subtype in human spinal cord.
Topics: Adrenergic alpha-Antagonists; Dioxanes; Humans; Idazoxan; In Vitro Techniques; Indicators and Reagents; Receptors, Adrenergic, alpha; Spinal Cord; Yohimbine | 1992 |
The effect of high concentrations of alpha 2-adrenoceptor antagonists on the lipolytic responsiveness of isolated human adipocytes.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Dioxanes; Female; Humans; Idazoxan; Isoproterenol; Lipolysis; Norepinephrine; Propanolamines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Yohimbine | 1992 |
Delineation of three pharmacological subtypes of alpha 2-adrenoceptor in the rat kidney.
Topics: Animals; Binding, Competitive; Computer Simulation; Dioxanes; Guanabenz; Idazoxan; In Vitro Techniques; Kidney; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1991 |
Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound.
Topics: Animals; Computer Simulation; Dioxanes; Guanfacine; Idazoxan; In Vitro Techniques; Isoquinolines; Kidney; Male; Monte Carlo Method; Piperazines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
Regulation of the alpha 2A-adrenergic receptor in the HT29 cell line. Effects of insulin and growth factors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding Sites; Blotting, Northern; Brimonidine Tartrate; Cyclic AMP; Dioxanes; Flow Cytometry; Glycolysis; Growth Substances; Humans; Idazoxan; Insulin; Kinetics; Nucleic Acid Hybridization; Quinoxalines; Receptors, Adrenergic, alpha; RNA, Messenger; Tumor Cells, Cultured | 1991 |
Evidence for central alpha-2 adrenoceptors, not imidazoline binding sites, mediating the ethanol-attenuating properties of alpha-2 adrenoceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Ataxia; Body Temperature; Brain; Dioxanes; Ethanol; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Mice; Motor Activity; Quinolizines; Receptors, Adrenergic, alpha; Receptors, Drug | 1991 |
[3H]rauwolscine behaves as an agonist for the 5-HT1A receptors in human frontal cortex membranes.
Topics: Adrenergic alpha-Antagonists; Aged; Dioxanes; Frontal Lobe; GTP-Binding Proteins; Guanine Nucleotides; Humans; Idazoxan; In Vitro Techniques; Kinetics; Membranes; Middle Aged; Mollusk Venoms; Phentolamine; Receptors, Adrenergic, alpha; Receptors, Serotonin; Yohimbine | 1991 |
Anorectic effect of alpha 2-antagonists in dog: effect of acute and chronic treatment.
Topics: Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Blood Glucose; Blood Platelets; Body Weight; Catecholamines; Cell Membrane; Dioxanes; Dogs; Fatty Acids, Nonesterified; Feeding Behavior; Idazoxan; Imidazoles; Insulin; Male; Nadolol; Yohimbine | 1991 |
Effect of a 7-day treatment with idazoxan and its 2-methoxy derivative RX 821002 [correction of RX 821001] on alpha 2-adrenoceptors and non-adrenoceptor idazoxan binding sites in rabbits.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Blood Platelets; Body Weight; Catecholamines; Colon; Dioxanes; Eating; Fatty Acids, Nonesterified; Hormones; Idazoxan; In Vitro Techniques; Organ Size; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Drug | 1991 |
The effects of idazoxan and other alpha 2-adrenoceptor antagonists on food and water intake in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Dose-Response Relationship, Drug; Drinking; Eating; Idazoxan; Male; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Drug | 1991 |
Rat spinal cord alpha 2-adrenoceptors are of the alpha 2A-subtype: comparison with alpha 2A- and alpha 2B-adrenoceptors in rat spleen, cerebral cortex and kidney using 3H-RX821002 ligand binding.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Computer Simulation; Dioxanes; Idazoxan; Kidney; Ligands; Male; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Spinal Cord; Spleen | 1991 |
New tools for human fat cell alpha-2A adrenoceptor characterization. Identification on membranes and on intact cells using the new antagonist [3H]RX821002.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Adult; Dioxanes; Dioxins; Female; Guanosine Triphosphate; Humans; Idazoxan; In Vitro Techniques; Kinetics; Magnesium; Middle Aged; Receptors, Adrenergic, alpha; Tritium; Yohimbine | 1990 |
Hamster adipocyte alpha 2-adrenoceptor changes during fat mass modifications are not directly dependent on adipose tissue norepinephrine content.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cricetinae; Dioxanes; Energy Intake; Food Deprivation; Hydroxydopamines; Idazoxan; Lipolysis; Male; Mesocricetus; Norepinephrine; Oxidopamine; Pindolol; Quinoxalines; Receptors, Adrenergic, alpha; Sympathectomy, Chemical | 1990 |
Binding of [3H]idazoxan and of its methoxy derivative [3H] RX821002 in human fat cells: [3H]idazoxan but not [3H] RX821002 labels additional non-alpha 2-adrenergic binding sites.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Binding Sites; Brimonidine Tartrate; Cell Membrane; Cystamine; Dioxanes; Dioxins; Epinephrine; Female; Humans; Idazoxan; Magnesium Chloride; Phenoxybenzamine; Potassium Chloride; Quinoxalines; Tritium; Yohimbine | 1990 |
Discrimination between alpha 2-adrenoceptors and [3H]idazoxan-labelled non-adrenergic sites in rabbit white fat cells.
Topics: Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Dioxanes; Dioxins; Epinephrine; Idazoxan; In Vitro Techniques; Kinetics; Lipolysis; Male; Quinoxalines; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Drug; Structure-Activity Relationship | 1990 |
Non-adrenergic sites for imidazolines are not directly involved in the alpha 2-adrenergic antilipolytic effect of UK 14304 in rat adipocytes.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Bucladesine; Cell Membrane; Colforsin; Dioxanes; Idazoxan; Kinetics; Lipolysis; Phentolamine; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Photoperiodic control of adipocyte alpha 2-adrenoceptors in Syrian hamsters: role of testosterone.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain; Brimonidine Tartrate; Cricetinae; Dioxanes; Idazoxan; Isoproterenol; Kidney; Light; Lipolysis; Male; Mesocricetus; Periodicity; Pindolol; Quinoxalines; Receptors, Adrenergic, alpha; Testosterone | 1990 |
Alpha-2 adrenoceptor in rat jejunum epithelial cells: characterization with [3H]RX821002 and distribution along the villus-crypt axis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; Dioxins; Drug Interactions; Epithelium; Idazoxan; Jejunum; Male; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1990 |
Identification of human platelet alpha 2-adrenoceptors with a new antagonist [3H]-RX821002, a 2-methoxy derivative of idazoxan.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Blood Platelets; Brimonidine Tartrate; Dioxanes; Epinephrine; Humans; Idazoxan; In Vitro Techniques; Kinetics; Male; Membranes; Oxymetazoline; Prazosin; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1990 |
Identification of alpha 2-adrenoceptors and non-adrenergic idazoxan binding sites in rabbit colon epithelial cells.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Colon; Dioxanes; Epithelial Cells; Epithelium; Idazoxan; In Vitro Techniques; Kinetics; Rabbits; Receptors, Adrenergic, alpha | 1990 |
Increased alpha 2-adrenergic binding sites and antilipolytic effect in adipocytes from genetically obese rats.
Topics: Adipose Tissue; Animals; Binding Sites; Brimonidine Tartrate; Dioxanes; Epinephrine; Idazoxan; Kinetics; Lipolysis; Male; Obesity; Propranolol; Quinoxalines; Rats; Rats, Zucker; Receptors, Adrenergic, alpha | 1990 |
Reserpine induces vascular alpha 2-adrenergic supersensitivity and platelet alpha 2-adrenoceptor up-regulation in dog.
Topics: Adipose Tissue; Animals; Blood Platelets; Blood Pressure; Cardiovascular System; Catecholamines; Cell Membrane; Clonidine; Dioxanes; Dogs; Heart Rate; Idazoxan; Male; Norepinephrine; Posture; Prazosin; Receptors, Adrenergic, alpha; Reserpine; Up-Regulation; Yohimbine | 1990 |
Evaluation of xylazine hydrochloride as the sole immobilizing agent in moose and caribou--and its subsequent reversal with idazoxan.
Topics: Adrenergic alpha-Antagonists; Animals; Deer; Dioxanes; Dioxins; Drug Evaluation; Idazoxan; Immobilization; Reindeer; Thiazines; Xylazine | 1989 |
[3H]RX821002: a new tool for the identification of alpha 2A-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Binding, Competitive; Catecholamines; Cell Membrane; Colforsin; Cyclic AMP; Dioxanes; Dioxins; Humans; Idazoxan; Kinetics; Radioligand Assay; Receptors, Adrenergic, alpha; Tumor Cells, Cultured; Yohimbine | 1989 |
Imidazolinic radioligands for the identification of hamster adipocyte alpha 2-adrenoceptors.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cricetinae; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Kinetics; Lipid Metabolism; Lipolysis; Male; Mesocricetus; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
Receptor binding and functional evidence suggest that postsynaptic alpha 2-adrenoceptors in rat brain are of the alpha 2D subtype.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzylamines; Binding Sites; Binding, Competitive; Cerebral Cortex; Clonidine; Dioxanes; Dopamine; Idazoxan; Male; Mydriasis; Neurons; Norepinephrine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Serotonin; Zimeldine | 1995 |
Rilmenidine-induced hypotension in conscious rabbits involves imidazoline-preferring receptors.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Dioxanes; Dose-Response Relationship, Drug; Female; Heart Rate; Hypotension; Idazoxan; Imidazoline Receptors; Male; Methyldopa; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1994 |
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Capillaries; Capillary Permeability; Clonidine; Dioxanes; Extravascular Lung Water; Guinea Pigs; Idazoxan; Oxazoles; Prazosin; Quinoxalines; Rilmenidine; Substance P; Trachea | 1995 |
Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Imidazoles; Lung; Methanol; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Yohimbine | 1995 |
LSL 60101, a selective ligand for imidazoline I2 receptors, on glial fibrillary acidic protein concentration.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Astrocytes; Benzofurans; Brain Chemistry; Cerebral Cortex; Dioxanes; Glial Fibrillary Acidic Protein; Idazoxan; Imidazoles; Imidazoline Receptors; Immunoblotting; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug; Up-Regulation | 1995 |
Molecular mechanisms underlying regional variations of catecholamine-induced lipolysis in rat adipocytes.
Topics: Adipocytes; Adrenergic beta-Agonists; Animals; Base Sequence; Brimonidine Tartrate; Bucladesine; Catecholamines; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Dioxanes; DNA Primers; Epididymis; Gene Expression; Idazoxan; Isoproterenol; Lipase; Lipolysis; Male; Molecular Sequence Data; Organ Specificity; Polymerase Chain Reaction; Propanolamines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; RNA, Messenger; Skin | 1995 |
Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Baclofen; Blood Pressure; Brain Mapping; Desipramine; Dioxanes; Fluoxetine; gamma-Aminobutyric Acid; Idazoxan; Imidazoles; Male; Medulla Oblongata; Microinjections; Nordefrin; Oxidopamine; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Sympatholytics; Time Factors | 1995 |
Alpha-2 adrenergic receptors in the bovine retina. Presence of only the alpha-2D subtype.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Dioxanes; Idazoxan; Pineal Gland; Radioligand Assay; Receptors, Adrenergic, alpha-2; Retina; Yohimbine | 1995 |
Pancreatic beta-cells express an imidazoline binding site that is distinct from I1 and I2 sites.
Topics: Adrenergic alpha-Antagonists; Animals; Cell Membrane; Cells, Cultured; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Receptors, Drug | 1995 |
In vivo modulation of norepinephrine and glutamate release through imidazoline receptors in the rat central nervous system.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Central Nervous System; Clonidine; Dioxanes; Glutamic Acid; Idazoxan; Imidazoline Receptors; Norepinephrine; Quinolines; Rats; Receptors, Drug | 1995 |
Mechanism of sympathoinhibition by imidazolines.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzazepines; Brimonidine Tartrate; Dioxanes; Hemodynamics; Idazoxan; Imidazoles; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1995 |
The relationship between density of alpha-adrenoceptor binding sites and contractile responses in several porcine isolated blood vessels.
Topics: 5'-Nucleotidase; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Cell Membrane; Dioxanes; Dose-Response Relationship, Drug; Drug Interactions; Ear, External; Idazoxan; Male; Microscopy, Electron; Muscle Contraction; Muscle, Smooth, Vascular; Prazosin; Radioligand Assay; Receptors, Adrenergic, alpha; Splenic Artery; Structure-Activity Relationship; Swine; Veins; Yohimbine | 1995 |
Recombinant human alpha 2-adrenoceptor subtypes: comparison of [3H]rauwolscine, [3H]atipamezole and [3H]RX821002 as radioligands.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding, Competitive; Buffers; Cell Line; Dioxanes; Humans; Idazoxan; Imidazoles; Kinetics; Mice; Radioligand Assay; Recombinant Proteins; Yohimbine | 1995 |
A thermodynamic analysis of estrogen regulation of alpha 2-adrenoceptor binding.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Dioxanes; Estradiol; Female; Guanylyl Imidodiphosphate; Hypothalamus; Idazoxan; Ligands; Ovariectomy; Oxymetazoline; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Temperature; Thermodynamics | 1995 |
Does [3H]2-methoxy-idazoxan (RX 821002) detect more alpha-2-adrenoceptor agonist high-affinity sites than [3H]rauwolscine? A comparison of nine tissues and cell lines.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line; Dioxanes; Epinephrine; Female; Guinea Pigs; Humans; Idazoxan; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1995 |
Characterization of binding sites for [3H]-idazoxan, [3H]-P-aminoclonidine and [3H]-rauwolscine in the kidney of the dog.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Clonidine; Dioxanes; Dogs; GTP-Binding Proteins; Idazoxan; Imidazoline Receptors; Kidney; Male; Radioligand Assay; Receptors, Drug; Yohimbine | 1994 |
Immunodetection of putative imidazoline receptor proteins in the human and rat brain and other tissues.
Topics: Adrenal Medulla; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoradiography; Brain Chemistry; Chromatography, Affinity; Clonidine; Dioxanes; Electrophoresis, Polyacrylamide Gel; Humans; Idazoxan; Imidazoline Receptors; Immunoblotting; Liver; Male; Medulla Oblongata; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tritium | 1994 |
Enhancement of the expression of the alpha 2-adrenoreceptor protein and mRNA by a direct effect of androgens in white adipocytes.
Topics: Adipocytes; Adrenergic alpha-Antagonists; Animals; Base Sequence; Blotting, Southern; Cricetinae; Dioxanes; DNA; DNA Primers; Female; Gene Expression; Idazoxan; In Vitro Techniques; Kinetics; Male; Mesocricetus; Molecular Sequence Data; Oligonucleotide Probes; Orchiectomy; Polymerase Chain Reaction; Rats; Receptors, Adrenergic, alpha-2; Restriction Mapping; RNA, Messenger; Sex Factors; Testosterone; Time Factors | 1995 |
Adipocyte alpha 2A-adrenoceptor is the only alpha 2-adrenoceptor regulated by testosterone.
Topics: Adipocytes; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Brain; Colon; Computer Simulation; Cricetinae; Dioxanes; Idazoxan; Kidney; Liver; Male; Mesocricetus; Molecular Sequence Data; Polymerase Chain Reaction; Receptors, Adrenergic, alpha; Receptors, Androgen; RNA, Complementary; RNA, Messenger; Sequence Alignment; Sequence Homology, Amino Acid; Testosterone; Up-Regulation | 1994 |
Inhibition of amine oxidase activity by derivatives that recognize imidazoline I2 sites.
Topics: Amine Oxidase (Copper-Containing); Animals; Binding Sites; Binding, Competitive; Cricetinae; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Mesocricetus; Monoamine Oxidase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug | 1995 |
Effects of alpha-2 adrenoceptor antagonists on rough-and-tumble play in juvenile rats: evidence for a site of action independent of non-adrenoceptor imidazoline binding sites.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Agonistic Behavior; Animals; Clonidine; Dioxanes; Female; Idazoxan; Imidazoline Receptors; Interpersonal Relations; Male; Prazosin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Drug | 1994 |
Acute and chronic effects of reserpine on biochemical and functional parameters of central and peripheral alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Clonidine; Dihydroxyphenylalanine; Dioxanes; Idazoxan; Injections, Subcutaneous; Male; Mydriasis; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Reserpine; Tyrosine 3-Monooxygenase; Vas Deferens | 1993 |
Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Azepines; Brimonidine Tartrate; Dioxanes; GTP Phosphohydrolases; Humans; Idazoxan; Isoproterenol; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Quinoxalines; Receptors, Adrenergic, alpha; Superoxides; Tritium; Tumor Cells, Cultured | 1994 |
Sympathoinhibition by rilmenidine in conscious rabbits: involvement of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Catecholamines; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Female; Heart Rate; Hemodynamics; Idazoxan; Kidney; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1993 |
Characterization of [3H]RX821002 binding to alpha-2 adrenergic receptor subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Cattle; CHO Cells; Cricetinae; Dioxanes; Female; Idazoxan; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1994 |
Estradiol reduction of the agonist high affinity form of the alpha 2-adrenoceptor in the hypothalamus of female rats: identification as the alpha 2D subtype.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; Dioxanes; Estradiol; Female; Hypothalamus; Idazoxan; Kinetics; Preoptic Area; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1994 |
Further characterization of human alpha 2-adrenoceptor subtypes: [3H]RX821002 binding and definition of additional selective drugs.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line; Dioxanes; Humans; Idazoxan; Plasmids; Radioligand Assay; Receptors, Adrenergic, alpha; Transfection | 1994 |
Similar ligand binding in recombinant human alpha 2 C2-adrenoceptors produced in mammalian, insect and yeast cells.
Topics: Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Cells, Cultured; Chlorpromazine; Dioxanes; Humans; Idazoxan; Immunoblotting; Mammary Neoplasms, Experimental; Mice; Molecular Sequence Data; Moths; Oxymetazoline; Prazosin; Receptors, Adrenergic, alpha; Recombinant Proteins; Saccharomyces cerevisiae; Transfection; Tumor Cells, Cultured; Yohimbine | 1994 |
Density of alpha-2A adrenoceptors and Gi proteins in the human brain: ratio of high-affinity agonist sites to antagonist sites and effect of age.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Binding Sites; Brain Chemistry; Brimonidine Tartrate; Child; Child, Preschool; Clonidine; Dioxanes; Female; GTP-Binding Proteins; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2 | 1994 |
Clinical and haematological changes in gazelles during xylazine/ketamine anaesthesia and following reversal with RX-821002A.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antelopes; Blood Cell Count; Dioxanes; Hemodynamics; Idazoxan; Injections, Intravenous; Ketamine; Male; Xylazine | 1994 |
Alpha 2-adrenoceptor subtypes identified by [3H]RX821002 binding in the human brain: the agonist guanoxabenz does not discriminate different forms of the predominant alpha 2A subtype.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Binding, Competitive; Brain; Dioxanes; Edetic Acid; Female; Guanabenz; Guanylyl Imidodiphosphate; Humans; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Male; Piperazines; Receptors, Adrenergic, alpha; Sodium Chloride; Tritium | 1994 |
Covariation of alpha 2-adrenoceptor density and function following irreversible antagonism with EEDQ.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Body Temperature; Dioxanes; Drug Interactions; Exploratory Behavior; Hypnotics and Sedatives; Idazoxan; Imidazoles; Male; Medetomidine; Mice; Motor Activity; Quinolines; Radioligand Assay; Receptors, Adrenergic, alpha-2 | 1994 |
Pharmacological characterization of [3H]idazoxan, [3H]RX821002 and p-[125I]iodoclonidine binding to alpha 2-adrenoceptors in rat cerebral cortical membranes.
Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Binding, Competitive; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1994 |
Multiple alpha 2 adrenergic receptor subtypes. I. Comparison of [3H]RX821002-labeled rat R alpha-2A adrenergic receptors in cerebral cortex to human H alpha2A adrenergic receptor and other populations of alpha-2 adrenergic subtypes.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood Platelets; Cerebral Cortex; Dioxanes; Humans; Idazoxan; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 1994 |
The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1- and I2-sites.
Topics: Animals; Benzofurans; Binding Sites; Dioxanes; Down-Regulation; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Male; Rats; Rats, Wistar; Receptors, Drug | 1994 |
Species orthologs of the alpha-2A adrenergic receptor: the pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors.
Topics: Animals; Binding Sites; Cattle; Cell Line; Dioxanes; Humans; Idazoxan; Rats; Receptors, Adrenergic, alpha-2; Species Specificity; Swine; Yohimbine | 1994 |
Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases.
Topics: 3T3 Cells; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Clone Cells; Clonidine; Cyclic AMP; Dioxanes; Humans; Idazoxan; Kinetics; Male; Mice; Pertussis Toxin; Quinolizines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1994 |
Involvement of imidazoline-preferring receptors in regulation of sympathetic tone.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Central Nervous System; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Oxazoles; Rabbits; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine | 1994 |
Mivazerol, a novel compound with high specificity for alpha 2 adrenergic receptors: binding studies on different human and rat membrane preparations.
Topics: Adult; Aged; Aged, 80 and over; Animals; Binding, Competitive; Blood Platelets; Cell Membrane; Dioxanes; Frontal Lobe; Humans; Idazoxan; Imidazoles; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Muscarinic; Receptors, Serotonin | 1994 |
Correlation between beta- and alpha-adrenergic receptor concentrations in human placenta.
Topics: Dihydroalprenolol; Dioxanes; Female; Humans; Idazoxan; Placenta; Pregnancy; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta | 1994 |
Discrimination and pharmacological characterization of I2-imidazoline sites with [3H]idazoxan and alpha-2 adrenoceptors with [3H]RX821002 (2-methoxy idazoxan) in the human and rat brains.
Topics: Adrenergic alpha-Antagonists; Adult; Animals; Brain; Brain Chemistry; Dioxanes; Epinephrine; Female; Humans; Idazoxan; Imidazoline Receptors; In Vitro Techniques; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Drug | 1993 |
Evidence for the existence of two forms of alpha 2A-adrenoceptors in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Line, Transformed; Cerebral Cortex; Chlorocebus aethiops; Dioxanes; Gene Expression; Idazoxan; Kidney; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Spinal Cord; Spleen | 1993 |
Alpha 2-adrenoceptor antagonist potencies of two hydroxylated metabolites of yohimbine.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Blood Platelets; Blood Proteins; Brimonidine Tartrate; Cell Membrane; Dioxanes; Epinephrine; Humans; Hydroxylation; Idazoxan; In Vitro Techniques; Lipolysis; Male; Platelet Aggregation; Protein Binding; Quinoxalines; Yohimbine | 1993 |
Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Cell Membrane; Colon; Dioxanes; Duodenum; Epinephrine; Epithelium; Humans; Idazoxan; Intestinal Mucosa; Kinetics; Microvilli; NAD; Organ Specificity; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha; RNA, Messenger; Virulence Factors, Bordetella | 1993 |
Coupling of the alpha 2-adrenergic receptor to the inhibitory G-protein Gi and adenylate cyclase in HT29 cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Dioxanes; GTP-Binding Proteins; Humans; Idazoxan; Pertussis Toxin; Quinoxalines; Receptors, Adrenergic, alpha; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Estradiol attenuates alpha 2-adrenoceptor-mediated inhibition of hypothalamic norepinephrine release.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Dioxanes; Estradiol; Female; Hypothalamus; Idazoxan; Norepinephrine; Ovariectomy; Potassium Chloride; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Yohimbine | 1993 |
Acute and chronic effects of cholinesterase inhibitors and pilocarpine on the density and sensitivity of central and peripheral alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Cholinesterase Inhibitors; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Isoflurophate; Male; Neostigmine; Physostigmine; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tyrosine 3-Monooxygenase; Vas Deferens | 1993 |
Motor and cardiovascular effects of selective alpha 2-adrenoceptor antagonists in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Decerebrate State; Dioxanes; Electric Stimulation; Female; Heart Rate; Idazoxan; Injections, Spinal; Male; Motor Neurons; Rabbits; Reflex; Retrospective Studies; Sural Nerve; Yohimbine | 1993 |
Acceleration by chronic treatment with clorgyline of the turnover of brain alpha 2-adrenoceptors in normotensive but not in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Brimonidine Tartrate; Cerebral Cortex; Clorgyline; Dioxanes; Down-Regulation; Hypertension; Idazoxan; In Vitro Techniques; Kinetics; Male; Membranes; Quinolines; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Species Specificity | 1993 |
Differential effects of the alkylating agent N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on brain alpha 2-adrenoceptors and I2-imidazoline sites in vitro and in vivo.
Topics: Animals; Binding Sites; Brain; Cell Membrane; Dioxanes; Idazoxan; Imidazoles; Isoenzymes; Kinetics; Male; Monoamine Oxidase; Neurons; Picolinic Acids; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Thermodynamics; Thiazoles; Tritium | 1993 |
Control of insulin secretion by imidazolines in rat pancreatic islets.
Topics: Animals; Benzofurans; Diazoxide; Dioxanes; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Rats | 1993 |
Alpha 2A adrenoceptors and non-adrenergic idazoxan binding sites in calf brain and retina are distinct from those in human brain.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cattle; Cell Membrane; Dioxanes; Frontal Lobe; Humans; Idazoxan; Receptors, Adrenergic, alpha; Retina; Species Specificity; Yohimbine | 1993 |
Opposite age-dependent changes of alpha 2A-adrenoceptors and nonadrenoceptor [3H]idazoxan binding sites (I2-imidazoline sites) in the human brain: strong correlation of I2 with monoamine oxidase-B sites.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Binding Sites; Brain; Child; Child, Preschool; Dioxanes; Female; Humans; Idazoxan; Imidazoline Receptors; Male; Middle Aged; Monoamine Oxidase; Picolinic Acids; Receptors, Adrenergic, alpha; Receptors, Drug; Thiazoles | 1993 |
Characterization of alpha 2A-adrenergic receptors in GT1 neurosecretory cells.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blotting, Northern; Cell Line; Colforsin; Dioxanes; Idazoxan; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1995 |
Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autonomic Nerve Block; Binding Sites; Blood Pressure; Central Nervous System; Consciousness; Dioxanes; Dogs; Dose-Response Relationship, Drug; Ganglia, Autonomic; Guanabenz; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Male; Oxazoles; Peripheral Nervous System; Receptors, Adrenergic, alpha-2; Receptors, Drug; Renal Circulation; Rilmenidine | 1995 |
Identification of drugs subtype-selective for alpha 2A-, alpha 2B-, and alpha 2C-adrenoceptors in the pig cerebellum and kidney cortex.
Topics: Animals; Binding, Competitive; Cerebellum; Dibenzazepines; Dioxanes; Idazoxan; Imidazoles; Kidney Cortex; Quinolizines; Receptors, Adrenergic, alpha-2; Swine | 1995 |
Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Benzofurans; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Electric Stimulation; Female; Guinea Pigs; Idazoxan; Imidazoles; Isotope Labeling; Male; Norepinephrine; Oxathiins; Quinolizines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tritium | 1996 |
Determination on functional basis of presynaptic alpha 2-adrenoceptor subtypes in guinea-pig duodenum.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cholinergic Fibers; Duodenum; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Male; Medetomidine; Muscle Contraction; Nordefrin; Norepinephrine; Oxymetazoline; Piperazines; Prazosin; Receptors, Adrenergic, alpha-2; Synaptic Membranes; Vasoconstrictor Agents; Xylazine; Yohimbine | 1996 |
Human adipocytes express alpha 2-adrenergic receptor of the alpha 2A-subtype only: pharmacological and genetic evidence.
Topics: Adipocytes; Adrenergic alpha-Antagonists; Adult; Cell Line; Female; Humans; Idazoxan; In Vitro Techniques; Membranes; Middle Aged; Quinolizines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Ribonucleases; RNA; RNA Probes | 1995 |
alpha 2A/D-Adrenoceptor subtype predominates also in the neonatal rat spinal cord.
Topics: Adrenergic alpha-Agonists; Age Factors; Animals; Animals, Newborn; Female; Idazoxan; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Tritium; Yohimbine | 1996 |
Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiac Catheterization; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Time Factors | 1996 |
Buffers differentially alter the binding of [3H]rauwolscine and [3H]RX821002 to the alpha-2 adrenergic receptor subtypes.
Topics: Animals; Buffers; CHO Cells; Cricetinae; Humans; Idazoxan; Kinetics; Opossums; Oxymetazoline; Prazosin; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Species Specificity; Yohimbine | 1996 |
An I2 imidazoline ligand, RS 45041, potentiates hyperalgesia in acute arthritis.
Topics: Acute Disease; Adrenergic alpha-Antagonists; Animals; Arthritis; Drug Evaluation, Preclinical; Drug Synergism; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Indoles; Injections, Spinal; Isoindoles; Neural Inhibition; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Drug | 1996 |
Alpha 2-adrenoceptor subtypes in the human brain: a pharmacological delineation of [3H]RX-821002 binding to membranes and tissue sections.
Topics: Adrenergic alpha-Antagonists; Adult; Autoradiography; Binding Sites; Binding, Competitive; Brain; Female; Frontal Lobe; Hippocampus; Humans; Idazoxan; Imidazoles; Indoles; Isoindoles; Male; Organ Specificity; Radioligand Assay | 1996 |
Alterations in the central nervous alpha 2-adrenoceptor system under chronic psychosocial stress.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Brimonidine Tartrate; Chronic Disease; Down-Regulation; Hydrocortisone; Idazoxan; Locus Coeruleus; Male; Nerve Tissue Proteins; Norepinephrine; Oxymetazoline; Pituitary-Adrenal System; Prefrontal Cortex; Quinoxalines; Receptors, Adrenergic, alpha-2; Social Dominance; Solitary Nucleus; Stress, Psychological; Tupaiidae; Up-Regulation; Vagus Nerve | 1996 |
Characterization of adrenoceptor types and subtypes in American bullfrogs acclimated to warm or cold temperature.
Topics: Acclimatization; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Binding, Competitive; Dose-Response Relationship, Drug; Humans; Idazoxan; Kidney; Membrane Proteins; Myocardium; Pindolol; Prazosin; Radioligand Assay; Rana catesbeiana; Receptors, Adrenergic; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Spinal Cord; Temperature | 1996 |
[3H]RX821002 (2-methoxyidazoxan) binds to alpha 2-adrenoceptor subtypes and a non-adrenoceptor imidazoline binding site in rat kidney.
Topics: Adrenergic alpha-Antagonists; Animals; Dose-Response Relationship, Drug; Idazoxan; Kidney; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1996 |
Genetic alteration of alpha 2C-adrenoceptor expression in mice: influence on locomotor, hypothermic, and neurochemical effects of dexmedetomidine, a subtype-nonselective alpha 2-adrenoceptor agonist.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Biogenic Monoamines; Body Temperature; Brain Chemistry; Idazoxan; Imidazoles; Medetomidine; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Motor Activity; Receptors, Adrenergic, alpha-2; RNA, Messenger | 1997 |
The central sympatho-inhibitory effect of 5,6-dihydroxy-2-dimethylaminotetralin (M7) is mediated by alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Blood Pressure; Central Nervous System; Cisterna Magna; Dogs; Dopamine Antagonists; Dose-Response Relationship, Drug; Emetics; Female; Heart Rate; Idazoxan; Male; Microinjections; Naphthols; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Splanchnic Nerves; Sympathetic Nervous System; Vagotomy | 1997 |
Effects of alpha 2-adrenoceptor antagonists and imidazoline2-receptor ligands on neuronal damage in global ischaemia in the rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Brain Ischemia; Hippocampus; Idazoxan; Imidazoles; Imidazoline Receptors; Ligands; Male; Neurons; Rats; Rats, Wistar; Receptors, Drug | 1997 |
Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance.
Topics: Adrenergic alpha-Agonists; Animals; Body Water; Brimonidine Tartrate; Guanfacine; Idazoxan; Kidney; Male; Naltrexone; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1997 |
Pharmacological characterization of I1 and I2 imidazoline receptors in human striatum.
Topics: Adrenergic alpha-Antagonists; Aged; Allosteric Regulation; Clonidine; Corpus Striatum; Female; Humans; Idazoxan; Imidazoline Receptors; Male; Middle Aged; Receptors, Drug; Structure-Activity Relationship | 1997 |
Densities of I2-imidazoline receptors, alpha 2-adrenoceptors and monoamine oxidase B in brains of suicide victims.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Brain; Female; Humans; Idazoxan; Imidazoline Receptors; Male; Middle Aged; Monoamine Oxidase; Receptors, Adrenergic, alpha; Receptors, Drug; Suicide; Tritium | 1997 |
Influence of prolonged fasting and thyroid hormone on the alpha 2-adrenergic response in isolated epididymal adipocytes of Wistar rats.
Topics: Adipocytes; Adipose Tissue; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Cell Separation; Epididymis; Fasting; Idazoxan; Male; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Time Factors; Triiodothyronine | 1997 |
Characterization of alpha-2D adrenergic receptor subtypes in bovine ocular tissue homogenates.
Topics: Adrenergic alpha-Antagonists; Animals; Cattle; Ciliary Body; Dose-Response Relationship, Drug; Eye; Idazoxan; Iris; Receptors, Adrenergic, alpha-2 | 1997 |
Functional consequences of constitutively active alpha2A-adrenergic receptor expression in 3T3F442A preadipocytes and adipocytes.
Topics: 3T3 Cells; Adipocytes; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Cell Division; Culture Media, Serum-Free; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Humans; Idazoxan; Kinetics; Lipolysis; Mice; Mutagenesis, Site-Directed; Phosphotyrosine; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Sodium Chloride; Transfection | 1997 |
Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Clonidine; Idazoxan; Imidazoles; Magnesium; Male; Manganese; Medetomidine; Membranes; Radioligand Assay; Rats; Reproducibility of Results; Retina; Sensitivity and Specificity; Tritium | 1997 |
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Clonidine; Electric Stimulation; Idazoxan; Ileum; In Vitro Techniques; Muscle Contraction; Oxymetazoline; Phentolamine; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Presynaptic | 1997 |
Alpha-adrenoceptors in equine digital veins: evidence for the presence of both alpha1 and alpha2-receptors mediating vasoconstriction.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Binding, Competitive; Brimonidine Tartrate; Dopamine; Horses; Idazoxan; In Vitro Techniques; Isometric Contraction; Methoxamine; Muscle, Smooth, Vascular; Norepinephrine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Vasoconstriction; Veins; Yohimbine | 1997 |
Investigation of the mechanisms underlying the hypophagic effects of the 5-HT and noradrenaline reuptake inhibitor, sibutramine, in the rat.
Topics: Adrenergic Uptake Inhibitors; Animals; Cyclobutanes; Eating; Idazoxan; Male; Metoprolol; Prazosin; Propanolamines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors | 1997 |
Expression of functional alpha2-adrenergic receptor subtypes in human corpus cavernosum and in cultured trabecular smooth muscle cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Cells, Cultured; Colforsin; Cyclic AMP; Humans; Idazoxan; Male; Muscle Contraction; Muscle, Smooth; Penis; Quinoxalines; Radioisotopes; Receptors, Adrenergic, alpha-2; Ribonucleases; RNA, Messenger; Yohimbine | 1997 |
Low-affinity conditions for agonists increase the binding of the antagonist [3H]RX821002 to the alpha(2B/C)-adrenoceptor subtypes in human brain and rat kidney.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Brain Chemistry; Guanylyl Imidodiphosphate; Humans; Idazoxan; Kidney; Male; Membranes; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium | 1997 |
Estradiol reduction of alpha 2-adrenoceptor binding in female rat cortex is correlated with decreases in alpha 2A/D-adrenoceptor messenger RNA.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebral Cortex; Down-Regulation; Estradiol; Female; Idazoxan; Ovariectomy; Rats; Receptors, Adrenergic, alpha; Reference Values; RNA, Messenger | 1997 |
Alpha2-adrenoceptor regulation of adenylyl cyclase in CHO cells: dependence on receptor density, receptor subtype and current activity of adenylyl cyclase.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; CHO Cells; Cricetinae; Cyclic AMP; Humans; Idazoxan; Ligands; Radioligand Assay; Receptors, Adrenergic, alpha-2 | 1997 |
Different apparent modes of inhibition of alpha2A-adrenoceptor by alpha2-adrenoceptor antagonists.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Humans; Idazoxan; Quinolizines; Receptors, Adrenergic, alpha-2; Tritium; Tumor Cells, Cultured; Yohimbine | 1997 |
Alpha 2-adrenergic autoreceptors in A5 and A6 neurons of neonate rats.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Brain; Idazoxan; In Vitro Techniques; Locus Coeruleus; Meglumine; Membrane Potentials; Neurons; Norepinephrine; Potassium; Potassium Channels; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Sodium; Tetrodotoxin | 1997 |
Sodium saccharin inhibits adenylyl cyclase activity in non-taste cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adrenergic alpha-Agonists; Animals; Astrocytes; Brimonidine Tartrate; Carcinogens; Cell Fractionation; Cell Membrane; Cerebral Cortex; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; GTP-Binding Proteins; Idazoxan; Male; Pertussis Toxin; Phenylisopropyladenosine; Quinoxalines; Rats; Rats, Wistar; Saccharin; Signal Transduction; Swine; Taste; Thyroid Gland; Virulence Factors, Bordetella | 1997 |
Evidence for altered central noradrenergic function in experimental acute liver failure in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Autoradiography; Cerebral Cortex; Chromatography, High Pressure Liquid; Coma; Dopamine; Frontal Lobe; Hippocampus; Hypothalamus; Idazoxan; Liver Failure, Acute; Microdialysis; Norepinephrine; Pindolol; Prazosin; Propanolamines; Putamen; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Serotonin; Thalamus | 1998 |
Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Autoradiography; Binding, Competitive; Brain Chemistry; Brimonidine Tartrate; Cell Membrane; Clonidine; Depression; Female; Frontal Lobe; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2; Suicide; Tritium | 1998 |
Alpha2-adrenergic receptor-mediated release of lysophosphatidic acid by adipocytes. A paracrine signal for preadipocyte growth.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; Adipocytes; Adult; Animals; Brimonidine Tartrate; Cell Differentiation; Cell Division; Cells, Cultured; Culture Techniques; Female; Humans; Idazoxan; Lysophospholipids; Mice; Paracrine Communication; Quinoxalines; Receptors, Adrenergic, alpha-2 | 1998 |
Simultaneous quantification of serotonin, dopamine and noradrenaline levels in single frontal cortex dialysates of freely-moving rats reveals a complex pattern of reciprocal auto- and heteroreceptor-mediated control of release.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Benzopyrans; Dopamine; Dopamine Agonists; Frontal Lobe; Guanabenz; Guinea Pigs; Homeostasis; Idazoxan; Imidazoles; Indoles; Isoindoles; Male; Medetomidine; Models, Neurological; Motor Activity; Norepinephrine; Oxadiazoles; Piperazines; Prazosin; Raclopride; Rats; Rats, Wistar; Receptors, Adrenergic; Receptors, Dopamine; Receptors, Serotonin; Salicylamides; Serotonin | 1998 |
Identification and characterization of non-adrenergic binding sites in insulin-secreting cells with the imidazoline RX821002.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Cell Line; Cell Membrane; Cells, Cultured; Diazoxide; Glucose; Idazoxan; Islets of Langerhans; Kinetics; Male; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cell Surface | 1997 |
[3H]RS79948-197 binding to human, rat, guinea pig and pig alpha2A-, alpha2B- and alpha2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine.
Topics: Adrenergic Agents; Animals; Guinea Pigs; Humans; Idazoxan; Isoquinolines; Naphthyridines; Quinolizines; Rats; Receptors, Adrenergic, alpha-2; Swine; Yohimbine | 1998 |
Effect of RX 821002 at 5-HT1A-receptors in rabbit spinal cord in vivo.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Female; Idazoxan; Male; Piperazines; Pyridines; Rabbits; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Spinal Cord | 1998 |
Localization and changes in distribution of brain alpha 2- and beta-adrenoceptors in response to acclimation state in the American bullfrog (Rana catesbeiana).
Topics: Acclimatization; Adrenergic alpha-Antagonists; Animals; Autoradiography; Brain; Brain Chemistry; Female; Idazoxan; Male; Rana catesbeiana; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Temperature | 1998 |
Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor.
Topics: Adrenergic alpha-Antagonists; Allosteric Regulation; Amiloride; Animals; CHO Cells; Cricetinae; Humans; Idazoxan; Protein Binding; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1998 |
Hypercapnia-induced long-term depression of respiratory activity requires alpha2-adrenergic receptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Carbon Dioxide; Hypercapnia; Hypoglossal Nerve; Idazoxan; Male; Norepinephrine; Phrenic Nerve; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Respiratory Mechanics; Vagotomy; Yohimbine | 1998 |
Do alpha 2-adrenoceptors and imidazoline binding sites coexist in the human term placenta? Evidence from direct binding studies.
Topics: Binding, Competitive; Cell Membrane; Female; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Placenta; Pregnancy; Protein Binding; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug | 1998 |
Post-hypoxic frequency decline does not depend on alpha2-adrenergic receptors in the adult rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Cerebral Ventricles; Guanabenz; Idazoxan; Infusions, Parenteral; Male; Rats; Rats, Sprague-Dawley; Respiratory Mechanics | 1998 |
Somatodendritic alpha2-adrenoceptors in the locus coeruleus are involved in the in vivo modulation of cortical noradrenaline release by the antidepressant desipramine.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; Dendrites; Desipramine; Electrophysiology; Gyrus Cinguli; Idazoxan; Locus Coeruleus; Male; Microdialysis; Neurons; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1998 |
Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: I. Effects on nonesterified fatty acid and plasma urea nitrogen concentrations in jugularly catheterized pigs.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Area Under Curve; Benzofurans; Blood Urea Nitrogen; Fatty Acids, Nonesterified; Female; Idazoxan; Imidazoles; Isoproterenol; Male; Random Allocation; Swine | 1998 |
Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: II. Nitrogen balance responses.
Topics: Administration, Oral; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animal Feed; Animals; Digestion; Dose-Response Relationship, Drug; Ethanolamines; Idazoxan; Injections, Subcutaneous; Linear Models; Male; Nitrogen; Random Allocation; Swine; Yohimbine | 1998 |
Effects of the alkylating agent EEDQ on regulatory G proteins and recovery of agonist and antagonist alpha2-adrenoceptor binding sites in rat brain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alkylating Agents; Animals; Brimonidine Tartrate; Cerebral Cortex; GTP-Binding Proteins; Idazoxan; Male; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley | 1998 |
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; CHO Cells; Cricetinae; Guanfacine; Humans; Idazoxan; Imidazoles; Ligands; Medetomidine; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Yohimbine | 1998 |
Prejunctional alpha2A-autoreceptors in the human gastric and ileocolic arteries.
Topics: Adrenergic alpha-Antagonists; Aged; Arteries; Autoreceptors; Colon; Dioxanes; Dopamine Antagonists; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gastric Mucosa; Humans; Idazoxan; Ileum; In Vitro Techniques; Male; Middle Aged; Neuromuscular Junction; Norepinephrine; Phentolamine; Prazosin; Receptors, Adrenergic, alpha-2; Spiro Compounds; Stomach; Tritium; Yohimbine | 1998 |
Antagonist precipitated clonidine withdrawal in rat: effects on locus coeruleus neurons, sympathetic nerves and cardiovascular parameters.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Inhalation; Animals; Blood Pressure; Cardiovascular System; Clonidine; Consciousness; Halothane; Heart Rate; Idazoxan; Imidazoles; Locus Coeruleus; Male; Neurons; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Substance Withdrawal Syndrome; Sympathetic Nervous System; Sympatholytics; Vascular Resistance | 1998 |
Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes.
Topics: Animals; Antihypertensive Agents; Binding, Competitive; Cerebral Cortex; Guanabenz; Idazoxan; Magnesium; Male; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spleen; Xanthine Oxidase | 1998 |
Modulation of agonist binding to recombinant human alpha2-adrenoceptors by sodium ions.
Topics: Adrenergic alpha-Agonists; Allosteric Regulation; Animals; Binding, Competitive; Cations, Monovalent; Guanylyl Imidodiphosphate; Humans; Idazoxan; Mammary Neoplasms, Animal; Mice; Norepinephrine; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Sodium; Tumor Cells, Cultured | 1998 |
The involvement of bulbospinal pathways in fentanyl-induced inhibition of spinal withdrawal reflexes in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Female; Fentanyl; Idazoxan; Injections, Intravenous; Injections, Intraventricular; Injections, Spinal; Male; Medulla Oblongata; Neural Inhibition; Neural Pathways; Rabbits; Reflex; Spinal Cord; Sural Nerve | 1998 |
The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception.
Topics: Abdominal Pain; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nefopam; Pain Measurement; Receptors, Adrenergic; Receptors, Opioid | 1999 |
Homologous regulation of the alpha2C-adrenoceptor subtype in human hepatocarcinoma, HepG2.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Binding, Competitive; Brimonidine Tartrate; Carcinoma, Hepatocellular; Humans; Idazoxan; Quinolizines; Quinoxalines; Receptors, Adrenergic, alpha-2; RNA, Messenger; Tritium; Tumor Cells, Cultured | 1999 |
G-protein activation by putative antagonists at mutant Thr373Lys alpha2A adrenergic receptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brimonidine Tartrate; COS Cells; GTP-Binding Proteins; Humans; Idazoxan; Inositol Phosphates; Mice; Mutation; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 1999 |
Clonidine evokes vasodepressor responses via alpha2-adrenergic receptors in gigantocellular reticular formation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Depression, Chemical; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Idazoxan; Male; Medulla Oblongata; Microinjections; Neurons; Prazosin; Rats; Rats, Sprague-Dawley; Reticular Formation | 1999 |
alpha2C adrenoceptors inhibit adenylyl cyclase in mouse striatum: potential activation by dopamine.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Animals; Cell Line; Colforsin; Corpus Striatum; Crosses, Genetic; Cyclic AMP; Dopamine; Enzyme Activation; Homozygote; Idazoxan; In Vitro Techniques; Kinetics; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Norepinephrine; Rats; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Reserpine; Transfection | 1999 |
Tonic adrenergic and serotonergic inhibition of a withdrawal reflex in rabbits subjected to different levels of surgical preparation.
Topics: Adrenergic alpha-Antagonists; Animals; Decerebrate State; Electric Stimulation; Electromyography; Escape Reaction; Female; Forelimb; Hindlimb Suspension; Idazoxan; Male; Muscle, Skeletal; Pain; Physical Stimulation; Piperazines; Pyridines; Rabbits; Reflex; Serotonin Antagonists; Skin | 1999 |
Differential modulation of alpha2-adrenoceptor subtypes in rat kidney by chronic desipramine treatment.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Clorgyline; Desipramine; Epinephrine; Idazoxan; Imidazoles; In Vitro Techniques; Indoles; Isoindoles; Isoquinolines; Kidney; Kinetics; Male; Monoamine Oxidase Inhibitors; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1999 |
Central moxonidine on water and NaCl intake.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Antihypertensive Agents; Carbachol; Cholinergic Agonists; Drinking; Idazoxan; Imidazoles; Injections, Intraventricular; Male; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Time Factors; Vasoconstrictor Agents | 1999 |
Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor.
Topics: Agmatine; Animals; Antazoline; Benzofurans; Cell Line; Cells, Cultured; Cerebellum; Dioxanes; Dizocilpine Maleate; Dose-Response Relationship, Drug; Electrophysiology; Glutamic Acid; Humans; Idazoxan; Imidazoles; Neuroprotective Agents; Patch-Clamp Techniques; Potassium; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Styrenes | 1999 |
Characterization of alpha2 adrenergic receptor subtypes in human ocular tissue homogenates.
Topics: Adrenergic alpha-Antagonists; Binding, Competitive; Choroid; Ciliary Body; Eye; Humans; Idazoxan; Iris; Pigment Epithelium of Eye; Radioligand Assay; Receptors, Adrenergic, alpha-2; Retina | 1999 |
Comparison of changes in the extracellular concentration of noradrenaline in rat frontal cortex induced by sibutramine or d-amphetamine: modulation by alpha2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Cerebral Cortex; Cyclobutanes; Dextroamphetamine; Idazoxan; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1999 |
Determination of the somatodendritic alpha2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Brimonidine Tartrate; Cerebral Cortex; Chromatography, High Pressure Liquid; Clonidine; Dendritic Cells; Drug Interactions; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Time Factors | 1999 |
Adrenergic alpha2C-receptors reside in rat striatal GABAergic projection neurons: comparison of radioligand binding and immunohistochemistry.
Topics: Adrenergic alpha-Antagonists; Animals; Antibodies; Autoradiography; Binding, Competitive; Brain Chemistry; Calbindin 1; Calbindin 2; Calbindins; Corpus Striatum; gamma-Aminobutyric Acid; Idazoxan; Immunohistochemistry; Male; Neurons; Norepinephrine; Parvalbumins; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; S100 Calcium Binding Protein G; Tissue Fixation; Tritium; Yohimbine | 1999 |
Autoradiographical and behavioural effects of a chronic infusion of antisense to the alpha2D-adrenoceptor in the rat.
Topics: Animals; Autoradiography; Base Sequence; Behavior, Animal; Body Temperature; Brain; Brimonidine Tartrate; Idazoxan; Injections, Intraventricular; Male; Pupil; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; RNA, Antisense | 1999 |
Modulation of sibutramine-induced increases in extracellular noradrenaline concentration in rat frontal cortex and hypothalamus by alpha2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Cyclobutanes; Dialysis; Frontal Lobe; Hypothalamus; Idazoxan; Imidazoles; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1999 |
Characterization of alpha-adrenoceptor subtypes in the corpus cavernosum of patients undergoing sex change surgery.
Topics: Adrenergic alpha-Antagonists; Binding, Competitive; Disorders of Sex Development; Dose-Response Relationship, Drug; Humans; Idazoxan; Male; Penis; Prazosin; Receptors, Adrenergic, alpha; Sulfonamides; Tamsulosin | 1999 |
Receptor subtype-induced targeting and subtype-specific internalization of human alpha(2)-adrenoceptors in PC12 cells.
Topics: Adrenergic alpha-Antagonists; Animals; Cell Differentiation; Cell Membrane; DNA, Complementary; Fluorescent Antibody Technique, Indirect; Humans; Idazoxan; Microscopy, Confocal; Neurites; PC12 Cells; Rats; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Transfection | 1999 |
In vitro mechanism of action on insulin release of S-22068, a new putative antidiabetic compound.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channels; Cell Line; Humans; Hypoglycemic Agents; Idazoxan; Imidazoles; Insulin; Islets of Langerhans; Membrane Potentials; Oocytes; Piperazines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Radioligand Assay; Receptor, Insulin; Rubidium Radioisotopes; Xenopus laevis | 1999 |
Non-adrenergic binding of [3H]atipamezole in rat kidney--regional distribution and comparison to alpha2-adrenoceptors.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Female; Idazoxan; Imidazoles; Kidney; Male; Membranes; Monoamine Oxidase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 1999 |
Effects of cortisol on brain alpha2-adrenoceptors: potential role in stress.
Topics: Adrenal Glands; Animals; Autoradiography; Body Weight; Brain Chemistry; Hydrocortisone; Idazoxan; Ligands; Male; Organ Size; Receptors, Adrenergic, alpha-2; Stress, Psychological; Tupaiidae | 1999 |
Clozapine reversal of the deficits in coordinated movement induced by D2 receptor blockade does not depend upon antagonism of alpha2 adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Ataxia; Clozapine; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Haloperidol; Idazoxan; Loxapine; Male; Muscarinic Antagonists; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Scopolamine; Yohimbine | 1999 |
Antagonistic effect of N-methyltyramine on alpha2-adrenoceptor in mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Idazoxan; Male; Mice; Radioligand Assay; Receptors, Adrenergic, alpha-2; Scopolamine; Tyramine | 1999 |
The role of 5-HT(1A)-receptors in fentanyl-induced bulbospinal inhibition of a spinal withdrawal reflex in the rabbit.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electrocardiography; Female; Fentanyl; Idazoxan; Injections, Intravenous; Injections, Intraventricular; Male; Piperazines; Pyridines; Rabbits; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Reflex; Serotonin Antagonists; Spinal Cord | 2000 |
Ligand recognition of serine-cysteine amino acid exchanges in transmembrane domain 5 of alpha2-adrenergic receptors by UK 14,304.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Chlorpromazine; CHO Cells; Cricetinae; Cysteine; Dopamine Antagonists; Humans; Idazoxan; Ligands; Mice; Models, Molecular; Molecular Sequence Data; Oxymetazoline; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Serine; Transfection; Tritium; Yohimbine | 2000 |
Hyperphagic effect of novel compounds with high affinity for imidazoline I(2) binding sites.
Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Drinking; Eating; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Wistar; Receptors, Drug | 2000 |
Synthesis and alpha-adrenergic binding ligand affinities of 2-iminoimidazolidine derivatives.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; Idazoxan; Imidazoles; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Spectrophotometry, Infrared; Yohimbine | 2000 |
Inverse agonism at alpha(2)-adrenoceptors in native tissue.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Guanosine Triphosphate; Idazoxan; Kinetics; Protein Binding; Quinolizines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 2000 |
Alpha(2)-adrenoceptor-stimulated GTP gamma S binding in rat brain: an autoradiographic study.
Topics: Animals; Autoradiography; Brain; Brimonidine Tartrate; Dose-Response Relationship, Drug; Epinephrine; Female; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Serotonin | 2000 |
Agonist efficacy at the alpha2A-adrenoceptor:G alpha15 fusion protein: an analysis based on Ca2+ responses.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Calcium; CHO Cells; Cricetinae; Epinephrine; Fluorescent Dyes; GTP-Binding Proteins; Humans; Idazoxan; Ligands; Mice; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Signal Transduction; Transfection | 2000 |
Imidazoline I(2)-receptors and spinal reflexes in the decerebrated rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clorgyline; Decerebrate State; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Indoles; Injections, Spinal; Isoindoles; Ligands; Male; Monoamine Oxidase Inhibitors; Pargyline; Rabbits; Receptors, Drug; Reflex; Spinal Cord | 2000 |
A further characterization of alpha-2 adrenoceptor involvement in the rough-and-tumble play of juvenile rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Idazoxan; Male; Norepinephrine; Play and Playthings; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 2000 |
Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Glucose; Brimonidine Tartrate; Heterozygote; Homeostasis; Humans; Idazoxan; Immunohistochemistry; Insulin; Islets of Langerhans; Mice; Mice, Transgenic; Promoter Regions, Genetic; Quinoxalines; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Restriction Mapping; Reverse Transcriptase Polymerase Chain Reaction | 2000 |
In vitro and in vivo approaches to the characterization of the alpha2-adrenoceptor.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Dopamine; Idazoxan; Norepinephrine; Oligonucleotides, Antisense; Rabbits; Rats; Receptors, Adrenergic, alpha-2; Thionucleotides | 1999 |
Heterogeneous ligand-mediated Ca(++) responses at wt and mutant alpha(2A)-adrenoceptors suggest multiple ligand activation binding sites at the alpha(2A)-adrenoceptor.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium Signaling; CHO Cells; Cricetinae; Humans; Idazoxan; Ligands; Mutagenesis, Site-Directed; Receptors, Adrenergic, alpha-2 | 2000 |
Inverse agonist activity at the alpha(2A)-adrenergic receptor.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Alkaloids; Animals; CHO Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Idazoxan; Imidazoline Receptors; Models, Biological; Mutation; Protein Conformation; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug | 2001 |
Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic alpha2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Clonidine; Desipramine; Dose-Response Relationship, Drug; Extracellular Space; Hippocampus; Idazoxan; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium | 2001 |
Brain alpha(2)-adrenoceptors in monoamine-depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Brain; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Gene Expression Regulation; GTP-Binding Proteins; Idazoxan; Male; Membranes; Norepinephrine; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reserpine; RNA, Messenger; Tritium | 2001 |
Agonist trafficking of G(i/o)-mediated alpha(2A)-adrenoceptor responses in HEL 92.1.7 cells.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Biological Transport; Calcium; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Idazoxan; Pertussis Toxin; Propranolol; Receptors, Adrenergic, alpha-2; Tumor Cells, Cultured; Virulence Factors, Bordetella; Yohimbine | 2001 |
A robust GTP-induced shift in alpha(2)-adrenoceptor agonist affinity in tissue sections from rat brain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Brimonidine Tartrate; GTP-Binding Proteins; Guanosine Triphosphate; Idazoxan; Microtomy; Nucleotides; Protein Binding; Quinoxalines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium | 2001 |
Alpha2A-adrenoceptor mediated tachypnea in awake goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Goats; Guanfacine; Heart Rate; Idazoxan; Periodicity; Receptors, Adrenergic, alpha-2; Respiratory Mechanics | 2001 |
Receptor phosphorylation mediates estradiol reduction of alpha2-adrenoceptor coupling to G protein in the hypothalamus of female rats.
Topics: Adrenergic alpha-Antagonists; Animals; beta-Adrenergic Receptor Kinases; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Estradiol; Female; Gene Expression; GTP-Binding Proteins; Hypothalamus; Idazoxan; Norepinephrine; Ovariectomy; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium | 2001 |
Rabbit alpha2-adrenoceptors: both platelets and adipocytes have alpha2A-pharmacology.
Topics: Adipocytes; Adrenergic alpha-Antagonists; Animals; Blood Platelets; Idazoxan; Norepinephrine; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-2; Species Specificity | 2001 |
Chronic subordination stress in male tree shrews: replacement of testosterone affects behavior and central alpha(2)-adrenoceptors.
Topics: Animals; Autoradiography; Behavior, Animal; Brain Chemistry; Dominance-Subordination; Epididymis; Idazoxan; Ligands; Male; Receptors, Adrenergic, alpha-2; Stress, Psychological; Testis; Testosterone; Tupaia | 2001 |
The alpha 2 adrenoceptor antagonists RX 821002 and yohimbine delay-dependently impair choice accuracy in a delayed non-matching-to-position task in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Conditioning, Operant; Dose-Response Relationship, Drug; Idazoxan; Male; Muscarinic Antagonists; Psychomotor Performance; Rats; Scopolamine; Yohimbine | 2001 |
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Catheterization; Clonidine; Drug Interactions; Ethanol; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug | 2001 |
Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha(2)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Gene Expression Regulation; Guanfacine; Hypertension; Idazoxan; Kidney; Male; Orchiectomy; Prazosin; Rats; Receptors, Adrenergic, alpha-2; RNA, Messenger; Sodium Chloride; Testosterone | 2002 |
In vitro and in vivo impairment of alpha2-adrenergic receptor-dependent antilipolysis by fatty acids in human adipose tissue.
Topics: Adipocytes; Adipose Tissue; Adrenergic Agents; Adult; Biopsy, Needle; Dietary Fats; Dose-Response Relationship, Drug; Epinephrine; Exercise; Fatty Acids; Female; Gene Expression; Glycerol; GTP-Binding Proteins; Humans; Idazoxan; Isoproterenol; Lipolysis; Middle Aged; Palmitates; Phentolamine; Receptors, Adrenergic, alpha-2 | 2001 |
Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Binding, Competitive; Biphenyl Compounds; Cell Line; Cerebral Cortex; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Kidney; Male; Mice; Models, Molecular; Rabbits; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 2002 |
Mechanisms involved in the water intake-related pressor response in the rat.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Brazil; Diazepam; Dose-Response Relationship, Drug; Drinking; Heart Rate; Idazoxan; Lidocaine; Losartan; Male; Mecamylamine; Models, Animal; Muscle Relaxants, Central; Prazosin; Quinine; Rats; Rats, Wistar; Sodium Chloride; Tropanes; Water | 2002 |
Seasonal changes in the densities of alpha(2) noradrenergic receptors are inversely related to changes in testosterone and the volumes of song control nuclei in male European starlings.
Topics: Adrenergic alpha-Antagonists; Animals; Idazoxan; Male; Neuronal Plasticity; Norepinephrine; Radioligand Assay; Receptors, Adrenergic, alpha-2; Seasons; Songbirds; Telencephalon; Testosterone; Tritium; Vocalization, Animal | 2002 |
alpha(2B)-Adrenergic receptors activate MAPK and modulate proliferation of primary cultured proximal tubule cells.
Topics: Adrenergic alpha-Antagonists; Animals; Arachidonic Acid; Calcimycin; Cell Division; Cell Line; Cell Membrane; Cells, Cultured; Enzyme Activation; Epinephrine; Humans; Idazoxan; Ionophores; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Kinase C; Quinolizines; Rats; Receptors, Adrenergic, alpha-2; Signal Transduction; Tritium; Virulence Factors, Bordetella | 2002 |
Different alpha-adrenoceptors mediate migration of vascular smooth muscle cells and adventitial fibroblasts in vitro.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Becaplermin; Cell Movement; Chemotaxis; Fibroblasts; Idazoxan; Muscle, Smooth, Vascular; Norepinephrine; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta | 2002 |
In vivo tonic modulation of the noradrenaline release in the rat cortex by locus coeruleus somatodendritic alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Dendrites; Dose-Response Relationship, Drug; Gyrus Cinguli; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Locus Coeruleus; Male; Microdialysis; Naphthyridines; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Time Factors | 2002 |
Imidazoline(2) (I(2)) binding site- and alpha(2)-adrenoceptor-mediated modulation of central noradrenergic and HPA axis function in control rats and chronically stressed rats with adjuvant-induced arthritis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenocorticotropic Hormone; Animals; Arthritis, Experimental; Chromatography, High Pressure Liquid; Hypothalamo-Hypophyseal System; Idazoxan; Imidazoles; Male; Microdialysis; Norepinephrine; Paraventricular Hypothalamic Nucleus; Pituitary-Adrenal System; Rats; Rats, Mutant Strains; Receptors, Adrenergic, alpha-2; Stress, Psychological | 2002 |
Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Decerebrate State; Dexmedetomidine; Dizocilpine Maleate; Drug Synergism; Efferent Pathways; Electric Stimulation; Excitatory Amino Acid Antagonists; Idazoxan; Imidazoles; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Neurons, Afferent; Rabbits; Reflex; Skin; Sural Nerve; Tarsus, Animal | 2002 |
Inhibition of pilocarpine-induced salivation in rats by central noradrenaline.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Idazoxan; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscarinic Agonists; Norepinephrine; Pilocarpine; Prazosin; Rats; Rats, Sprague-Dawley; Saliva; Salivation; Statistics as Topic; Yohimbine | 2002 |
Enhanced stability of wild-type and constitutively active alpha(2A)-adrenoceptors by ligands with agonist, silent and inverse agonist properties.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; CHO Cells; Cricetinae; Drug Interactions; GTP-Binding Proteins; Guanosine Triphosphate; Idazoxan; Imidazoles; Protein Binding; Radioligand Assay; Receptors, Adrenergic, alpha-2; Time Factors; Transfection; Up-Regulation | 2002 |
Alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angioplasty, Balloon; Animals; Carotid Artery Injuries; Cell Division; Idazoxan; Imines; Indoles; Male; Muscle, Smooth, Vascular; Norepinephrine; Oxathiins; Piperazines; Piperidines; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Recurrence; Tunica Intima; Vasoconstrictor Agents | 2002 |
Biochemical and functional characterization of alpha-adrenergic receptors in the rabbit vagina.
Topics: Administration, Intravaginal; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Drug Therapy, Combination; Female; Idazoxan; In Vitro Techniques; Isometric Contraction; Ligands; Muscle, Smooth, Vascular; Oxyhemoglobins; Prazosin; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha; Sexual Behavior; Vagina; Vasodilator Agents | 2002 |
Effects of medullary alpha2-adrenoceptor blockade in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Idazoxan; Injections, Intravenous; Injections, Intraventricular; Kidney; Male; Medulla Oblongata; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Solitary Nucleus; Sympathetic Nervous System | 2002 |
Different roles for Gi and Go proteins in modulation of adenylyl cyclase type-2 activity.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Heterotrimeric GTP-Binding Proteins; Humans; Idazoxan; Pertussis Toxin; Protein Kinase C; Receptors, Adrenergic, alpha-2; Signal Transduction; Spodoptera; Tetradecanoylphorbol Acetate | 2002 |
Central alpha(2) adrenergic receptors and cholinergic-induced salivation in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Idazoxan; Imidazoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Muscarinic Agonists; Pilocarpine; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Salivation; Sympatholytics; Yohimbine | 2003 |
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 2003 |
Piribedil enhances frontocortical and hippocampal release of acetylcholine in freely moving rats by blockade of alpha 2A-adrenoceptors: a dialysis comparison to talipexole and quinelorane in the absence of acetylcholinesterase inhibitors.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Antagonists; Animals; Azepines; Brimonidine Tartrate; Cholinesterase Inhibitors; Dialysis; Dopamine; Dopamine Agonists; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Idazoxan; Piribedil; Prefrontal Cortex; Quinolines; Quinoxalines; Rats; Rats, Wistar | 2003 |
Regional distribution of alpha(2C)-adrenoceptors in brain and spinal cord of control mice and transgenic mice overexpressing the alpha(2C)-subtype: an autoradiographic study with [(3)H]RX821002 and [(3)H]rauwolscine.
Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Brain; Female; Idazoxan; Mice; Mice, Inbred Strains; Mice, Transgenic; Neurons; Norepinephrine; Radioligand Assay; Receptors, Adrenergic, alpha-2; Spinal Cord; Synaptic Transmission; Tritium; Up-Regulation; Yohimbine | 2003 |
Mechanisms involved in the pressor response to noradrenaline injection into the cingulate cortex of unanesthetized rats.
Topics: Adrenergic alpha-Antagonists; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Blood Pressure; Dioxanes; Dose-Response Relationship, Drug; Ganglionic Blockers; Gyrus Cinguli; Heart Rate; Hypophysectomy; Idazoxan; Male; Mecamylamine; Microinjections; Norepinephrine; Phenoxybenzamine; Rats; Rats, Wistar | 2003 |
Constitutive precoupling to G(i) and increased agonist potency in the alpha(2B)-adrenoceptor.
Topics: Adrenergic alpha-Antagonists; Amino Acid Motifs; Animals; Aspartic Acid; Calcium; CHO Cells; Cricetinae; Cytoplasm; Dexmedetomidine; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Idazoxan; Ligands; Mutagenesis, Site-Directed; Mutation; Pertussis Toxin; Protein Binding; Protein Conformation; Receptors, Adrenergic, alpha-2; Signal Transduction | 2003 |
[3H]RX 821002 in human dorsolateral prefrontal cortex: no changes in postmortem tissue from subjects with schizophrenia.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adult; Aged; Benzodiazepines; Binding Sites; Clozapine; Female; Hippocampus; Humans; Idazoxan; Male; Middle Aged; Olanzapine; Postmortem Changes; Prefrontal Cortex; Schizophrenia; Serotonin Antagonists | 2003 |
Nandrolone treatment decreases the level of rat kidney alpha(1B)-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Anabolic Agents; Animals; Idazoxan; Injections, Intramuscular; Kidney; Ligands; Male; Nandrolone; Prazosin; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spleen | 2003 |
Androgen-induced norepinephrine release mediating guinea pig seminal vesicle smooth muscle proliferation: potential role of pre-synaptic alpha2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cell Division; Dihydrotestosterone; Guinea Pigs; Idazoxan; Male; Muscle, Smooth; Norepinephrine; Receptors, Adrenergic, alpha-2; Receptors, Presynaptic; Seminal Vesicles; Sexual Maturation; Tritium | 2003 |
Molecular mechanisms of ligand-receptor interactions in transmembrane domain V of the alpha2A-adrenoceptor.
Topics: Adrenergic Agonists; Amino Acid Sequence; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; Brimonidine Tartrate; Catecholamines; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Ligands; Membrane Proteins; Models, Molecular; Molecular Structure; Mutation; Protein Structure, Tertiary; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Sequence Homology, Amino Acid; Sulfur Radioisotopes; Tritium | 2003 |
Alpha-2 adrenergic receptor development in rat CNS: an autoradiographic study.
Topics: Animals; Animals, Newborn; Autoradiography; Brain; Central Nervous System; Idazoxan; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 2004 |
Imidazoline2 (I2) receptor- and alpha2-adrenoceptor-mediated modulation of hypothalamic-pituitary-adrenal axis activity in control and acute restraint stressed rats.
Topics: Acute Disease; Adrenergic alpha-Antagonists; Animals; Corticosterone; Dose-Response Relationship, Drug; Hypothalamo-Hypophyseal System; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Restraint, Physical; Stress, Psychological; Time Factors | 2004 |
Effects of tramadol on alpha2-adrenergic receptors in the rat brain.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Autoradiography; Brain; Drug Administration Schedule; Idazoxan; Male; Narcotics; Protein Binding; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Tramadol; Tritium | 2004 |
Treatment with alpha2-adrenoceptor antagonist, 2-methoxy idazoxan, protects 6-hydroxydopamine-induced Parkinsonian symptoms in rats: neurochemical and behavioral evidence.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Brain Chemistry; Catalepsy; Disease Models, Animal; Dopamine; Drug Interactions; Hydroxyindoleacetic Acid; Idazoxan; Male; Motor Activity; Norepinephrine; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Reaction Time; Serotonin; Statistics, Nonparametric | 2004 |
[Ethyl-3H]RS-79948-197 alpha2-adrenoceptor autoradiography validation in alpha2-adrenoceptor knockout mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Autoradiography; Binding Sites; Binding, Competitive; Cerebral Cortex; Idazoxan; In Vitro Techniques; Isoquinolines; Ligands; Mice; Mice, Knockout; Naphthyridines; Oxymetazoline; Phentolamine; Prazosin; Putamen; Radioligand Assay; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine | 2004 |
Clonidine increases caspase-3 mRNA level and DNA fragmentation in the developing rat brainstem.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, Competitive; Brain Stem; Caspase 3; Caspases; Cell Differentiation; Clonidine; DNA Fragmentation; Female; Idazoxan; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; RNA, Messenger; Up-Regulation | 2004 |
Activation of alpha2-adrenergic receptors into the lateral parabrachial nucleus enhances NaCl intake in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Appetite; Blood Pressure; Captopril; Diuretics; Drinking Behavior; Furosemide; Genes, fos; Idazoxan; Imidazoles; Immunohistochemistry; Male; Pons; Prosencephalon; Rats; Receptors, Adrenergic, alpha-2; Sodium Chloride, Dietary | 2004 |
Attenuation of alpha2A-adrenergic receptor expression in neonatal rat brain by RNA interference or antisense oligonucleotide reduced anxiety in adulthood.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Animals, Genetically Modified; Animals, Newborn; Anxiety; Behavior, Animal; Blotting, Southern; Brain Stem; Gene Expression Regulation, Developmental; Idazoxan; Maze Learning; Norepinephrine; Oligodeoxyribonucleotides, Antisense; Protein Binding; Radioligand Assay; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tritium | 2004 |
Estimation of endogenous noradrenaline release in rat brain in vivo using [3H]RX 821002.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Brain; Dextroamphetamine; Idazoxan; Imidazoles; Male; Microdialysis; Monoamine Oxidase Inhibitors; Norepinephrine; Radioligand Assay; Rats; Rats, Wistar; Selegiline; Time Factors; Tissue Distribution; Tritium | 2005 |
Influence of neonatal short-term reduction in brainstem alpha2A-adrenergic receptors on receptor ontogenesis, acoustic startle reflex, and prepulse inhibition in rats.
Topics: Adrenergic alpha-Antagonists; Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Brain; Brain Stem; Gene Expression Regulation, Developmental; Idazoxan; Inhibition, Psychological; Oligonucleotides, Antisense; Protein Binding; Radioligand Assay; Random Allocation; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reflex, Acoustic; Reflex, Startle; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium | 2004 |
Serotonergic influence on the potentiation of D-amphetamine and apomorphine-induced rotational behavior by the alpha2-adrenoceptor antagonist 2-methoxy idazoxan in hemiparkinsonian rats.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Apomorphine; Behavior, Animal; Dextroamphetamine; Drug Synergism; Idazoxan; Male; Motor Activity; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Serotonin; Sympatholytics | 2005 |
The alpha-2B adrenoceptor in the paraventricular thalamic nucleus is persistently upregulated by chronic psychosocial stress.
Topics: Animals; Chronic Disease; Idazoxan; Male; Midline Thalamic Nuclei; Protein Binding; Receptors, Adrenergic, alpha-2; Social Behavior; Stress, Psychological; Tupaia; Up-Regulation | 2004 |
A comparison of neurokinin 1 receptor knock-out (NK1-/-) and wildtype mice: exploratory behaviour and extracellular noradrenaline concentration in the cerebral cortex of anaesthetised subjects.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Area Under Curve; Behavior, Animal; Cerebral Cortex; Chromatography, High Pressure Liquid; Desipramine; Drug Interactions; Electrochemistry; Enzyme Inhibitors; Exploratory Behavior; Extracellular Space; Idazoxan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Motor Activity; Norepinephrine; Reaction Time; Receptors, Neurokinin-1; Time Factors | 2005 |
alpha-Adrenergic and muscarinic cholinergic receptors are not involved in the modulation of the parasympathetic baroreflex by the medial prefrontal cortex in rats.
Topics: Animals; Atropine; Baroreflex; Cobalt; Dioxanes; Idazoxan; Male; Parasympathetic Nervous System; Phenylephrine; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Muscarinic | 2005 |
Ontogenesis of mRNA levels and binding sites of hepatic alpha-adrenoceptors in young cattle.
Topics: Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Binding, Competitive; Blood Glucose; Cattle; Female; Glycogen; Idazoxan; Liver; Phosphoenolpyruvate; Prazosin; Pregnancy; Pyruvate Carboxylase; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2006 |
Long-lasting effects of yohimbine on the ejaculatory function in male dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dogs; Ejaculation; Idazoxan; Male; Penile Erection; Sexual Behavior, Animal; Time Factors; Yohimbine | 2005 |
Compensatory changes in the noradrenergic nervous system in the locus ceruleus and hippocampus of postmortem subjects with Alzheimer's disease and dementia with Lewy bodies.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Dendrites; Female; Fluoxetine; Hippocampus; Humans; Idazoxan; In Situ Hybridization; Lewy Body Disease; Locus Coeruleus; Male; Middle Aged; Nerve Tissue Proteins; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; RNA, Messenger; Tetralones; Tyrosine 3-Monooxygenase | 2006 |
Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Base Sequence; Brain; Clonidine; DNA Primers; Idazoxan; Mice; Mice, Knockout; Norepinephrine Plasma Membrane Transport Proteins; Polymerase Chain Reaction; Receptors, Adrenergic, alpha-2; RNA, Messenger | 2006 |
Role of CNS alpha1-adrenoceptor activity in central fos responses to novelty.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Brain Chemistry; Central Nervous System; Dialysis; Exploratory Behavior; Idazoxan; Immunohistochemistry; Male; Oncogene Proteins v-fos; Phenylephrine; Prazosin; Protein Binding; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1 | 2006 |
Prenatal cocaine exposure alters alpha2 receptor expression in adolescent rats.
Topics: Adrenergic alpha-Antagonists; Age Factors; Animals; Autoradiography; Body Weight; Cocaine; Dopamine Uptake Inhibitors; Female; Idazoxan; Male; Pregnancy; Prenatal Exposure Delayed Effects; Prosencephalon; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sexual Maturation; Tritium | 2006 |
Pharmacological characterization and autoradiographic distribution of alpha2-adrenoceptor antagonist [3H]RX 821002 binding sites in the chicken brain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brain; Chickens; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; In Vitro Techniques; Male; Oxymetazoline; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin; Tritium | 2006 |
Analysis of brain adrenergic receptors in dopamine-beta-hydroxylase knockout mice.
Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Brain; Dopamine beta-Hydroxylase; Gene Expression Regulation, Developmental; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Isotopes; Mice; Mice, Inbred C57BL; Mice, Knockout; Pindolol; Prazosin; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 2006 |
Alpha2-adrenergic activation in the lateral parabrachial nucleus induces NaCl intake under conditions of systemic hyperosmolarity.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Behavior, Animal; Drinking; Drinking Behavior; Drug Interactions; Idazoxan; Imidazoles; Male; Medulla Oblongata; Neural Inhibition; Rats; Receptors, Adrenergic, alpha-2; Sodium Chloride, Dietary; Time Factors | 2006 |
Pharmacologic characterization of the cloned human trace amine-associated receptor1 (TAAR1) and evidence for species differences with the rat TAAR1.
Topics: Animals; Base Sequence; Cyclic AMP; Humans; Idazoxan; Isoproterenol; Molecular Sequence Data; Phenethylamines; Rats; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Receptors, G-Protein-Coupled; Species Specificity; Structure-Activity Relationship | 2007 |
mRNA expression and binding sites for alpha2-adrenergic receptor subtypes in muscle layers of the ileum and spiral colon of dairy cows.
Topics: Animals; Cattle; DNA Primers; Female; Idazoxan; Lower Gastrointestinal Tract; Muscle, Smooth; Protein Binding; Receptors, Adrenergic, alpha-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tritium | 2006 |
Contribution of imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla to sympathetic baroreflex inhibition by systemic rilmenidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Dose-Response Relationship, Drug; Idazoxan; Imidazoline Receptors; Injections, Intravenous; Kidney; Medulla Oblongata; Neural Inhibition; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System | 2007 |
Adrenergic drugs modify the level of noradrenaline in the insular cortex and alter extinction of conditioned taste aversion in rats.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Avoidance Learning; Blood Glucose; Cerebral Cortex; Conditioning, Classical; Drinking Behavior; Extinction, Psychological; Guanfacine; Idazoxan; Male; Microdialysis; Norepinephrine; Rats; Rats, Long-Evans; Receptors, Adrenergic, alpha-2; Taste | 2007 |
Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Dementia; Female; Gene Expression Regulation; Humans; Idazoxan; Male; Middle Aged; Postmortem Changes; Prazosin; Prefrontal Cortex; Receptors, Adrenergic; RNA, Messenger | 2007 |
Disruption of noradrenergic transmission and the behavioural response to a novel environment in NK1R-/- mice.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Autoradiography; Behavior, Animal; Desipramine; Drug Interactions; Electrochemistry; Exploratory Behavior; Frontal Lobe; Guanosine 5'-O-(3-Thiotriphosphate); Idazoxan; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Norepinephrine; Phosphorus Isotopes; Reaction Time; Receptors, Neurokinin-1 | 2007 |
Dopamine binds to alpha(2)-adrenergic receptors in the song control system of zebra finches (Taeniopygia guttata).
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Clozapine; Dopamine; Finches; Haloperidol; Homeostasis; Idazoxan; Male; Raclopride; Receptors, Adrenergic, alpha-2; Vocalization, Animal | 2008 |
Role of the bed nucleus of the stria terminalis in the cardiovascular responses to acute restraint stress in rats.
Topics: Animals; Blood Pressure; Cardiovascular System; Cobalt; Dioxanes; Heart Rate; Idazoxan; Male; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Restraint, Physical; Stress, Psychological; Synaptic Transmission; Thalamic Nuclei; Tropanes | 2009 |
Interplay among catecholamine systems: dopamine binds to alpha2-adrenergic receptors in birds and mammals.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Birds; Brain; Catecholamines; Cells, Cultured; Coturnix; Dopamine; Female; Finches; Idazoxan; Male; Mammals; Neurons; Norepinephrine; Organ Culture Techniques; Radioligand Assay; Rats; Rats, Long-Evans; Receptor Cross-Talk; Receptors, Adrenergic, alpha-2; Receptors, Dopamine | 2008 |
Differential effects of neonatal norepinephrine lesions on immediate early gene expression in developing and adult rat brain.
Topics: Adrenergic Agents; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Benzylamines; Brain; Cytoskeletal Proteins; Early Growth Response Protein 1; Female; Gene Expression Regulation, Developmental; Idazoxan; Immediate-Early Proteins; Male; Nerve Tissue Proteins; Norepinephrine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley | 2008 |
Activation of alpha(2)-adrenoceptors in the lateral hypothalamus reduces pilocarpine-induced salivation in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Drug Interactions; Hypothalamic Area, Lateral; Idazoxan; Imidazoles; Male; Muscarinic Agonists; Norepinephrine; Pilocarpine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Salivation | 2009 |
Probable involvement of alpha(2C)-adrenoceptor subtype and endogenous opioid peptides in the peripheral antinociceptive effect induced by xylazine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Dinoprostone; Dose-Response Relationship, Drug; Hyperalgesia; Idazoxan; Imidazoles; Leucine; Male; Naloxone; Opioid Peptides; Pain; Pain Measurement; Rats; Rats, Wistar; Xylazine; Yohimbine | 2009 |
Modulation of inflammatory response via alpha2-adrenoceptor blockade in acute murine colitis.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Cells, Cultured; Colitis; Colon; Cytokines; Dextran Sulfate; Dopamine beta-Hydroxylase; Idazoxan; Immunohistochemistry; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Models, Animal; Quinoxalines; Tyrosine 3-Monooxygenase | 2009 |
Alpha adrenergic modulation on effects of norepinephrine transporter inhibitor reboxetine in five-choice serial reaction time task.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Attention; Discrimination, Psychological; Drug Evaluation, Preclinical; Drug Interactions; Feeding Behavior; Idazoxan; Impulsive Behavior; Male; Morpholines; Norepinephrine Plasma Membrane Transport Proteins; Prazosin; Rats; Rats, Sprague-Dawley; Reaction Time; Reboxetine; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spatial Behavior; Time Perception | 2009 |
Insular cortex alpha1-adrenoceptors modulate the parasympathetic component of the baroreflex in unanesthetized rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Baroreflex; Blood Pressure; Cerebral Cortex; Dioxanes; Heart Rate; Idazoxan; Male; Norepinephrine; Parasympathetic Nervous System; Phenylephrine; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Regression Analysis; Synaptic Transmission | 2009 |
Adrenergic mechanisms of the Kölliker-Fuse/A7 area on the control of water and sodium intake.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Captopril; Dietary Sucrose; Drinking Behavior; Furosemide; Idazoxan; Male; Natriuretic Agents; Norepinephrine; Pons; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Water | 2009 |
α2-adrenergic drugs modulate the binding of [18F]fallypride to dopamine D2/3 receptors in striatum of living mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzamides; Binding, Competitive; Brain Mapping; Clonidine; Corpus Striatum; Dopamine; Female; Idazoxan; Mice; Mice, Inbred BALB C; Positron-Emission Tomography; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Yohimbine | 2010 |
Investigation of the distribution and function of alpha-adrenoceptors in the sheep isolated internal anal sphincter.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anal Canal; Animals; Antibodies, Monoclonal; Autoradiography; Binding, Competitive; Dose-Response Relationship, Drug; Fecal Incontinence; Humans; Idazoxan; Immunohistochemistry; In Vitro Techniques; Muscle Contraction; Prazosin; Protein Binding; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Sheep | 2010 |
Selective enhancement of mesocortical dopaminergic transmission by noradrenergic drugs: therapeutic opportunities in schizophrenia.
Topics: Adrenergic Agents; Animals; Antipsychotic Agents; Cognition; Dopamine; Dopamine Agents; Dopamine Plasma Membrane Transport Proteins; Electric Stimulation; Haloperidol; Idazoxan; Male; Microdialysis; Molecular Targeted Therapy; Morpholines; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Wistar; Reboxetine; Schizophrenia; Synaptic Transmission; Ventral Tegmental Area | 2011 |
Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Chromones; Clonidine; Excitatory Postsynaptic Potentials; Female; Idazoxan; Models, Animal; Motor Neurons; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Sensory Receptor Cells; Spasm; Spinal Cord Injuries; Synaptic Transmission | 2011 |
Bed nucleus of the stria terminalis α1- and α2-adrenoceptors differentially modulate the cardiovascular responses to exercise in rats.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Dioxanes; Exercise Tolerance; Idazoxan; Male; Physical Conditioning, Animal; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Septal Nuclei; Synaptic Transmission | 2011 |
Inhibition of sodium appetite by lipopolysaccharide: involvement of alpha2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Appetite; Blood Pressure; Body Temperature; Dose-Response Relationship, Drug; Gastric Emptying; Heart Rate; Idazoxan; Injections, Intraperitoneal; Lipopolysaccharides; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Sodium Chloride, Dietary; Yohimbine | 2011 |
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Brimonidine Tartrate; Clonidine; Desipramine; Disease Models, Animal; Idazoxan; Locus Coeruleus; Male; MAP Kinase Signaling System; Medulla Oblongata; Neuralgia; Norepinephrine; Prefrontal Cortex; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Signal Transduction; Spinal Cord | 2012 |
Lateral septal area α1- and α2-adrenoceptors differently modulate baroreflex activity in unanaesthetized rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Baroreflex; Blood Pressure; Dioxanes; Heart Rate; Idazoxan; Male; Norepinephrine; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Septal Nuclei; Synaptic Transmission; Tachycardia | 2012 |
Moxonidine into the lateral parabrachial nucleus reduces renal and hormonal responses to cell dehydration.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Arginine Vasopressin; Atrial Natriuretic Factor; Blood Volume; Brachial Plexus; Dehydration; Diuresis; Hormones; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Male; Natriuresis; Osmolar Concentration; Oxytocin; Potassium; Rats; Rats, Sprague-Dawley; Renin; Sodium; Sodium Chloride; Water-Electrolyte Balance | 2012 |
The predicted N-terminal signal sequence of the human α₂C-adrenoceptor does not act as a functional cleavable signal peptide.
Topics: Amino Acid Sequence; Animals; Cell Membrane; COS Cells; Humans; Idazoxan; Ligands; Molecular Sequence Data; Protein Sorting Signals; Protein Structure, Secondary; Proteolysis; Receptors, Adrenergic, alpha-2; Transfection | 2012 |
Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Conditioning, Psychological; Dioxanes; Electroshock; Fear; Idazoxan; Imidazoles; Male; Phentolamine; Propanolamines; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta-1; Septal Nuclei | 2012 |
α1 and α2-adrenoceptors in the medial amygdaloid nucleus modulate differently the cardiovascular responses to restraint stress in rats.
Topics: Adrenergic alpha-Antagonists; Amygdala; Animals; Blood Pressure; Dioxanes; Heart Rate; Idazoxan; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Restraint, Physical; Stress, Psychological | 2012 |
The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Idazoxan; Male; Methoxamine; Movement; Neurons; Norepinephrine; Nucleus Accumbens; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 2012 |
Blockade of α2-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: a combined qPCR, in situ hybridisation and immunocytochemistry study.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Brain Chemistry; Cytoskeletal Proteins; Excitatory Amino Acid Antagonists; Idazoxan; Image Processing, Computer-Assisted; Imidazoles; Immunohistochemistry; In Situ Hybridization; Male; Nerve Tissue Proteins; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA; Serotonin | 2012 |
Effect of tapentadol on neurons in the locus coeruleus.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Antagonists; Analgesics, Opioid; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; Locus Coeruleus; Male; Narcotic Antagonists; Neural Inhibition; Neurons; Phenols; Quinolines; Rats; Rats, Sprague-Dawley; Tapentadol | 2013 |
Commissural nucleus of the solitary tract regulates the antihypertensive effects elicited by moxonidine.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Consciousness; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Injections; Injections, Intraventricular; Male; Neurons; Rats; Rats, Inbred SHR; Rats, Wistar; Solitary Nucleus; Stereotaxic Techniques; Yohimbine | 2013 |
Amphetamine and cocaine suppress social play behavior in rats through distinct mechanisms.
Topics: Adrenergic Agents; Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Animals; Atomoxetine Hydrochloride; Behavior, Animal; Cocaine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Exploratory Behavior; Fluoxetine; Flupenthixol; Idazoxan; Male; Motor Activity; Piperazines; Play and Playthings; Propylamines; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Social Behavior | 2014 |
Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiovascular System; Cerebral Cortex; Dioxanes; Heart Rate; Idazoxan; Male; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Restraint, Physical; Stress, Mechanical; Synaptic Transmission | 2014 |
Prevention of neutrophil extravasation by α2-adrenoceptor-mediated endothelial stabilization.
Topics: Adherens Junctions; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Animals; Antigens, CD; beta Catenin; Brimonidine Tartrate; Cadherins; CD11b Antigen; Endothelium, Vascular; gamma Catenin; Humans; Idazoxan; Inflammation; Intercellular Adhesion Molecule-1; L-Selectin; Male; Mice; Neutrophils; Peritonitis; Quinoxalines; Receptors, Adrenergic, alpha-2; Thioglycolates; Transendothelial and Transepithelial Migration; Tumor Necrosis Factor-alpha; Up-Regulation; Xylazine; Zymosan | 2014 |
Vagotomy reveals the importance of the imidazoline receptors in the cardiovascular effects of marsanidine and 7-ME-marsanidine in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Blood Pressure; Heart Rate; Idazoxan; Imidazolidines; Imidazoline Receptors; Indazoles; Infusions, Intravenous; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Vagotomy | 2014 |
Electroconvulsive shocks decrease α2-adrenoceptor binding in the Flinders rat model of depression.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Autoradiography; Biophysics; Brain; Depression; Disease Models, Animal; Electroshock; Female; Idazoxan; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tritium | 2015 |
α2-adrenoceptor binding in Flinders-sensitive line compared with Flinders-resistant line and Sprague-Dawley rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Neurons; Animals; Autoradiography; Brain; Depression; Disease Models, Animal; Female; Idazoxan; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 2015 |
Effects of abstinence from chronic cocaine self-administration on nonhuman primate dorsal and ventral noradrenergic bundle terminal field structures.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Autoradiography; Brain; Cocaine; Cocaine-Related Disorders; Fluoxetine; Idazoxan; Macaca mulatta; Male; Neural Pathways; Norepinephrine Plasma Membrane Transport Proteins; Receptors, Adrenergic, alpha-2; Reinforcement Schedule; Self Administration | 2016 |
Contrasting Roles of Dopamine and Noradrenaline in the Motivational Properties of Social Play Behavior in Rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic Uptake Inhibitors; Animals; Atomoxetine Hydrochloride; Cocaine; Conditioning, Operant; Dopamine; Dopamine Antagonists; Dopamine Uptake Inhibitors; Flupenthixol; Idazoxan; Male; Methylphenidate; Motivation; Neuropsychological Tests; Norepinephrine; Piperazines; Random Allocation; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Dopamine; Social Behavior | 2016 |
Effects of lisdexamfetamine in a rat model of binge-eating.
Topics: Animals; Baclofen; Behavior, Animal; Benzazepines; Benzodiazepines; Body Weight; Bulimia; Disease Models, Animal; Eating; Feeding Behavior; Female; Idazoxan; Lisdexamfetamine Dimesylate; Naltrexone; Olanzapine; Prazosin; Prodrugs; Raclopride; Rats; Rats, Wistar; Rolipram | 2015 |
Peculiar Effects of Selective Blockade of α2-Adrenoceptor Subtypes on Cardiac Chronotropy in Newborn Rats.
Topics: Acridines; Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Newborn; Heart; Heart Conduction System; Heart Rate; Idazoxan; Imidazoles; Myocardial Contraction; Piperazines; Rats; Receptors, Adrenergic, alpha-2; Receptors, Presynaptic; Tachycardia | 2015 |
Interdependent adrenergic receptor regulation of Arc and Zif268 mRNA in cerebral cortex.
Topics: Adrenergic Antagonists; Animals; Cerebral Cortex; Cytoskeletal Proteins; Early Growth Response Protein 1; Idazoxan; Nerve Tissue Proteins; Prazosin; Propranolol; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; RNA, Messenger | 2016 |
Circulatory effect of TCS-80, a new imidazoline compound, in rats.
Topics: Animals; Benzofurans; Blood Pressure; Heart Rate; Hypotension; Idazoxan; Imidazoles; Imidazolidines; Imidazoline Receptors; Imidazolines; Indazoles; Male; Rats; Receptors, Adrenergic, alpha-2 | 2016 |
Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration.
Topics: Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Apoptosis; Autoreceptors; Blotting, Western; Brain; CASP8 and FADD-Like Apoptosis Regulating Protein; Cerebral Cortex; Clorgyline; Desipramine; Electroshock; Excitatory Amino Acid Antagonists; Fas-Associated Death Domain Protein; Fluoxetine; Idazoxan; Indans; Ketamine; Male; Mianserin; Mirtazapine; Monoamine Oxidase Inhibitors; Norepinephrine Plasma Membrane Transport Proteins; Phenelzine; Phosphoproteins; Phosphorylation; Rats; RNA-Binding Proteins; Thiazoles | 2016 |
A new, simple and robust radioligand binding method used to determine kinetic off-rate constants for unlabeled ligands. Application at α2A- and α2C-adrenoceptors.
Topics: HEK293 Cells; Humans; Idazoxan; Kinetics; Ligands; Protein Binding; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins | 2016 |
Selective Blockade of α
Topics: Acridines; Adrenergic alpha-2 Receptor Antagonists; Animals; Animals, Outbred Strains; Dose-Response Relationship, Drug; Heart Atria; Heart Ventricles; Idazoxan; Imidazoles; Myocardial Contraction; Piperazines; Rats; Receptors, Adrenergic, alpha-2; Tissue Culture Techniques | 2016 |
Noradrenergic signaling in the VTA modulates cocaine craving.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Behavior, Animal; Cocaine; Conditioning, Operant; Craving; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Idazoxan; Male; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Self Administration; Ventral Tegmental Area | 2018 |
Stress augments the rewarding memory of cocaine via the activation of brainstem-reward circuitry.
Topics: Adrenergic alpha-Antagonists; Adrenergic Neurons; Animals; Brain Stem; Cocaine; Conditioning, Psychological; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Idazoxan; Male; Memory; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Adrenergic, beta; Restraint, Physical; Reward; Stress, Psychological; Tegmentum Mesencephali; Timolol | 2019 |
On the central noradrenergic mechanism underlying the social play-suppressant effect of methylphenidate in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Central Nervous System Stimulants; Cerebral Cortex; Exploratory Behavior; Habenula; Idazoxan; Male; Methylphenidate; Motor Activity; Neural Pathways; Rats, Wistar; Receptors, Adrenergic, alpha-2; Reward; Social Behavior | 2018 |
Opioid and noradrenergic contributions of tapentadol to the inhibition of locus coeruleus neurons in the streptozotocin rat model of polyneuropathic pain.
Topics: Action Potentials; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Idazoxan; Locus Coeruleus; Male; Naloxone; Neural Inhibition; Neurons; Pain Measurement; Rats; Tapentadol | 2018 |
Responsiveness of α2-adrenoceptor/I1-imidazoline receptor in the rostral ventrolateral medulla to cardiovascular regulation is enhanced in conscious spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Blood Pressure Determination; Clonidine; Consciousness; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System | 2019 |
Noradrenergic modulation determines respiratory network activity during temperature changes in the in vitro brainstem of bullfrogs.
Topics: Action Potentials; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Brain Stem; Female; Idazoxan; In Vitro Techniques; Motor Neurons; Norepinephrine; Prazosin; Rana catesbeiana; Respiration; Spinal Cord; Temperature | 2018 |