rx 821002 has been researched along with guanfacine in 6 studies
| Studies (rx 821002) | Trials (rx 821002) | Recent Studies (post-2010) (rx 821002) | Studies (guanfacine) | Trials (guanfacine) | Recent Studies (post-2010) (guanfacine) |
|---|---|---|---|---|---|
| 317 | 0 | 45 | 784 | 180 | 273 |
| Protein | Taxonomy | rx 821002 (IC50) | guanfacine (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 1.453 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.134 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.249 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 6.447 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 3.014 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 1.453 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 2.098 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Uhlén, S; Wikberg, JE | 1 |
| Intengan, HD; Smyth, DD | 1 |
| Audinot, V; Chaput, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Richard, N; Touzard, M; Verrièle, L | 1 |
| Bisgard, GE; Herman, JK; O'Halloran, KD | 1 |
| Dausse, JP; Giudicelli, Y; Ilhami, N; Khalid, M | 1 |
| Angst, MJ; Fresquet, N; Gobaille, S; Sandner, G; Schleef, C | 1 |
6 other study(ies) available for rx 821002 and guanfacine
| Article | Year |
|---|---|
Delineation of rat kidney alpha 2A- and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an alpha 2A-selective compound.
Topics: Animals; Computer Simulation; Dioxanes; Guanfacine; Idazoxan; In Vitro Techniques; Isoquinolines; Kidney; Male; Monte Carlo Method; Piperazines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha | 1991 |
Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance.
Topics: Adrenergic alpha-Agonists; Animals; Body Water; Brimonidine Tartrate; Guanfacine; Idazoxan; Kidney; Male; Naltrexone; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1997 |
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; CHO Cells; Cricetinae; Guanfacine; Humans; Idazoxan; Imidazoles; Ligands; Medetomidine; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Yohimbine | 1998 |
Alpha2A-adrenoceptor mediated tachypnea in awake goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Goats; Guanfacine; Heart Rate; Idazoxan; Periodicity; Receptors, Adrenergic, alpha-2; Respiratory Mechanics | 2001 |
Testosterone dependence of salt-induced hypertension in Sabra rats and role of renal alpha(2)-adrenoceptor subtypes.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Gene Expression Regulation; Guanfacine; Hypertension; Idazoxan; Kidney; Male; Orchiectomy; Prazosin; Rats; Receptors, Adrenergic, alpha-2; RNA, Messenger; Sodium Chloride; Testosterone | 2002 |
Adrenergic drugs modify the level of noradrenaline in the insular cortex and alter extinction of conditioned taste aversion in rats.
Topics: Adrenergic Agents; Analysis of Variance; Animals; Avoidance Learning; Blood Glucose; Cerebral Cortex; Conditioning, Classical; Drinking Behavior; Extinction, Psychological; Guanfacine; Idazoxan; Male; Microdialysis; Norepinephrine; Rats; Rats, Long-Evans; Receptors, Adrenergic, alpha-2; Taste | 2007 |