rx 821002 has been researched along with clonidine in 47 studies
| Studies (rx 821002) | Trials (rx 821002) | Recent Studies (post-2010) (rx 821002) | Studies (clonidine) | Trials (clonidine) | Recent Studies (post-2010) (clonidine) |
|---|---|---|---|---|---|
| 317 | 0 | 45 | 13,692 | 2,044 | 1,394 |
| Protein | Taxonomy | rx 821002 (IC50) | clonidine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.101 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0115 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.21 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.002 | |
| Nischarin | Rattus norvegicus (Norway rat) | 0.3662 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.26) | 18.7374 |
| 1990's | 24 (51.06) | 18.2507 |
| 2000's | 16 (34.04) | 29.6817 |
| 2010's | 5 (10.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| England, CD; Smith, CF; Stillings, MR; Welbourn, AP | 1 |
| Harms, GS; Lohse, MJ; Steinmeyer, R; Vilardaga, JP | 1 |
| Callado, LF; Meana, JJ; Ortega, JE; Rodriguez, F; Rozas, I | 1 |
| Callado, LF; Erdozain, AM; Meana, JJ; Ortega, JE; Rodriguez, F; Rozas, I | 2 |
| Callado, LF; Erdozain, AM; Goonan, A; Kahvedzić, A; McCabe, T; Meana, JJ; Nagle, PS; Rodriguez, F; Rozas, I | 1 |
| Berlan, M; Estan, L; Montastruc, JL; Senard, JM; Tran, MA | 1 |
| Carpéné, C; Lafontan, M; Langin, D; Saulnier-Blache, JS | 1 |
| Buckett, WR; Butler, SA; Cheetham, SC; Gosden, J; Heal, DJ; Prow, MR | 1 |
| Advenier, C; Biyah, K | 1 |
| Hussain, JF; Kendall, DA; Pinthong, D; Wilson, VG | 1 |
| Goiny, M; Herrera-Marschitz, M; Meana, JJ | 1 |
| Evans, RG; Haynes, JM | 1 |
| Escribá, PV; García-Sevilla, JA; Regunathan, S; Reis, DJ; Sastre, M; Wang, H | 1 |
| Atrens, DM; Fleischhauer, AE; Kuhlman, SJ; Siviy, SM | 1 |
| García-Sevilla, JA; Garro, MA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L | 1 |
| García-Sevilla, JA; Sastre, M | 1 |
| Muskardin, DT; Wallace, DR; Zahniser, NR | 1 |
| Bouloumié, A; Devedjian, JC; Lafontan, M; Planat, V; Record, M; Saulnier-Blache, JS; Valet, P | 1 |
| Head, GA; Sannajust, F | 1 |
| Asier Garro, M; García-Sevilla, JA; Giralt, MT; Menargues, A; Miralles, A; Obach, R; Olmos, G; Pineda, J; Ugedo, L | 1 |
| Chan, CK; Head, GA | 1 |
| Czerwiec, E; De Backer, JP; Flamez, A; Ladure, P; Vauquelin, G | 1 |
| Bol, CJ; Danhof, M; IJzerman, AP; Mandema, JW | 1 |
| Coupar, IM; Liu, L | 1 |
| Callado, LF; García-Sevilla, JA; Grijalba, B; Meana, JJ; Pazos, A; Sastre, M | 1 |
| Baertschi, AJ; Grubb, MC; Guyenet, PG; Pence, R; Stornetta, RL | 1 |
| Gray, AM; Nevinson, MJ; Sewell, RD | 1 |
| Aicher, SA; Drake, CT | 1 |
| Mateo, Y; Meana, JJ | 1 |
| Fukazawa, H; Ishida, H; Koda, H; Kuriyama, K; Matsumoto, N; Nukaya, H; Suwa, Y; Tsuji, K; Yokoo, Y | 1 |
| Benamour, K; Chang-Fong, J; Cussac, M; Morand, JM; Szymonski, B; Thomasson, F | 1 |
| Baliko, CN; Siviy, SM | 1 |
| Bernini, M; Gobbi, M; Mennini, T; Parini, S; Pirona, L; Sacchetti, G; Samanin, R | 1 |
| Busquets, X; García-Sevilla, JA; Miralles, A; Ribas, C | 1 |
| Bisgard, GE; Herman, JK; O'Halloran, KD | 1 |
| Abdel-Rahman, AA; El-Mas, MM | 1 |
| Bouysset, F; Cordi, A; Laubie, M; Vayssettes-Courchay, C; Verbeuren, TJ | 1 |
| Godwin, SJ; Head, GA; Parkin, ML | 1 |
| Bannova, AV; Dygalo, NN; Kalinina, TS; Shishkina, GT | 1 |
| Amano, T; Ebiko, M; Kimura, Y; Sakurada, S; Yonezawa, A; Yoshizumii, M | 1 |
| Bönisch, H; Brüss, M; Caron, MG; Dziedzicka-Wasylewska, M; Faron-Górecka, A; Gilsbach, R; Rogóz, Z | 1 |
| Arszol, C; Bartenstein, P; Böning, G; Cumming, P; Josef Gildehaus, F; Mille, E; Rominger, A; Wängler, B | 1 |
| Bennett, DJ; D'Amico, J; Gorassini, MA; Murray, KC; Rank, MM; Stephens, MJ | 1 |
| Alba-Delgado, C; Berrocoso, E; Borges, G; Horrillo, I; Meana, JJ; Mico, JA; Neto, F; Ortega, JE; Sánchez-Blázquez, P | 1 |
| Aono, Y; Cools, AR; Koshikawa, N; Saigusa, T; Takada, K; Uchida, T; Verheij, MM | 1 |
| Nakamoto, M; Ohya, Y; Sakima, A; Takishita, S; Yamazato, M; Yamazato, Y | 1 |
47 other study(ies) available for rx 821002 and clonidine
| Article | Year |
|---|---|
Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Clonidine; Dioxanes; Dioxins; Imidazoles; Male; Mice; Muscle Contraction; Phenylephrine; Piperidines; Piperoxan; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Structure-Activity Relationship | 1986 |
Molecular basis of inverse agonism in a G protein-coupled receptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Cell Line; Fluorescence Resonance Energy Transfer; Humans; Ligands; Protein Binding; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Signal Transduction | 2005 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha(2)-adrenoceptor antagonists, 1: toward new antidepressants with heteroatomic linkers.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Binding, Competitive; Blood-Brain Barrier; Brain; Guanidines; Humans; Imidazolines; In Vitro Techniques; Male; Microdialysis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2007 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor antagonists. 2. Exploring alkyl linkers for new antidepressants.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents; Blood-Brain Barrier; Brain; Guanidines; Humans; Imidazoles; Imidazolines; In Vitro Techniques; Male; Microdialysis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stilbenes; Structure-Activity Relationship; Tetrahydronaphthalenes | 2008 |
Novel synthesis and pharmacological evaluation as alpha2-adrenoceptor ligands of O-phenylisouronium salts.
Topics: Adrenergic alpha-2 Receptor Antagonists; Antidepressive Agents; Brain; Crystallography, X-Ray; Drug Evaluation, Preclinical; Humans; Ligands; Models, Molecular; Molecular Structure; Salts; Stereoisomerism; Structure-Activity Relationship; Sulfides; Urea | 2008 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Microdialysis; Neurons; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 2009 |
Reserpine induces vascular alpha 2-adrenergic supersensitivity and platelet alpha 2-adrenoceptor up-regulation in dog.
Topics: Adipose Tissue; Animals; Blood Platelets; Blood Pressure; Cardiovascular System; Catecholamines; Cell Membrane; Clonidine; Dioxanes; Dogs; Heart Rate; Idazoxan; Male; Norepinephrine; Posture; Prazosin; Receptors, Adrenergic, alpha; Reserpine; Up-Regulation; Yohimbine | 1990 |
Imidazolinic radioligands for the identification of hamster adipocyte alpha 2-adrenoceptors.
Topics: Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Clonidine; Cricetinae; Dioxanes; Idazoxan; Imidazoles; In Vitro Techniques; Kinetics; Lipid Metabolism; Lipolysis; Male; Mesocricetus; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha; Yohimbine | 1989 |
Receptor binding and functional evidence suggest that postsynaptic alpha 2-adrenoceptors in rat brain are of the alpha 2D subtype.
Topics: Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzylamines; Binding Sites; Binding, Competitive; Cerebral Cortex; Clonidine; Dioxanes; Dopamine; Idazoxan; Male; Mydriasis; Neurons; Norepinephrine; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Serotonin; Zimeldine | 1995 |
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Capillaries; Capillary Permeability; Clonidine; Dioxanes; Extravascular Lung Water; Guinea Pigs; Idazoxan; Oxazoles; Prazosin; Quinoxalines; Rilmenidine; Substance P; Trachea | 1995 |
Comparison of the interaction of agmatine and crude methanolic extracts of bovine lung and brain with alpha 2-adrenoceptor binding sites.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Binding, Competitive; Brimonidine Tartrate; Cattle; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Imidazoles; Lung; Methanol; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha-2; Yohimbine | 1995 |
In vivo modulation of norepinephrine and glutamate release through imidazoline receptors in the rat central nervous system.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Central Nervous System; Clonidine; Dioxanes; Glutamic Acid; Idazoxan; Imidazoline Receptors; Norepinephrine; Quinolines; Rats; Receptors, Drug | 1995 |
Characterization of binding sites for [3H]-idazoxan, [3H]-P-aminoclonidine and [3H]-rauwolscine in the kidney of the dog.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Binding, Competitive; Clonidine; Dioxanes; Dogs; GTP-Binding Proteins; Idazoxan; Imidazoline Receptors; Kidney; Male; Radioligand Assay; Receptors, Drug; Yohimbine | 1994 |
Immunodetection of putative imidazoline receptor proteins in the human and rat brain and other tissues.
Topics: Adrenal Medulla; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoradiography; Brain Chemistry; Chromatography, Affinity; Clonidine; Dioxanes; Electrophoresis, Polyacrylamide Gel; Humans; Idazoxan; Imidazoline Receptors; Immunoblotting; Liver; Male; Medulla Oblongata; Rats; Rats, Sprague-Dawley; Receptors, Drug; Tritium | 1994 |
Effects of alpha-2 adrenoceptor antagonists on rough-and-tumble play in juvenile rats: evidence for a site of action independent of non-adrenoceptor imidazoline binding sites.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Agonistic Behavior; Animals; Clonidine; Dioxanes; Female; Idazoxan; Imidazoline Receptors; Interpersonal Relations; Male; Prazosin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Drug | 1994 |
Acute and chronic effects of reserpine on biochemical and functional parameters of central and peripheral alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Clonidine; Dihydroxyphenylalanine; Dioxanes; Idazoxan; Injections, Subcutaneous; Male; Mydriasis; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Reserpine; Tyrosine 3-Monooxygenase; Vas Deferens | 1993 |
Density of alpha-2A adrenoceptors and Gi proteins in the human brain: ratio of high-affinity agonist sites to antagonist sites and effect of age.
Topics: Adolescent; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Aged; Aged, 80 and over; Aging; Binding Sites; Brain Chemistry; Brimonidine Tartrate; Child; Child, Preschool; Clonidine; Dioxanes; Female; GTP-Binding Proteins; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2 | 1994 |
Pharmacological characterization of [3H]idazoxan, [3H]RX821002 and p-[125I]iodoclonidine binding to alpha 2-adrenoceptors in rat cerebral cortical membranes.
Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Binding, Competitive; Cerebral Cortex; Clonidine; Dioxanes; Idazoxan; Male; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1994 |
Alpha 2-adrenergic stimulation promotes preadipocyte proliferation. Involvement of mitogen-activated protein kinases.
Topics: 3T3 Cells; Adenylate Cyclase Toxin; Adenylyl Cyclases; Adipocytes; Adipose Tissue; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cells, Cultured; Clone Cells; Clonidine; Cyclic AMP; Dioxanes; Humans; Idazoxan; Kinetics; Male; Mice; Pertussis Toxin; Quinolizines; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1994 |
Involvement of imidazoline-preferring receptors in regulation of sympathetic tone.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Central Nervous System; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Oxazoles; Rabbits; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine | 1994 |
Acute and chronic effects of cholinesterase inhibitors and pilocarpine on the density and sensitivity of central and peripheral alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brain; Brimonidine Tartrate; Cholinesterase Inhibitors; Clonidine; Dioxanes; Idazoxan; In Vitro Techniques; Isoflurophate; Male; Neostigmine; Physostigmine; Pilocarpine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Tyrosine 3-Monooxygenase; Vas Deferens | 1993 |
Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiac Catheterization; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Time Factors | 1996 |
Pharmacological characterization of I1 and I2 imidazoline receptors in human striatum.
Topics: Adrenergic alpha-Antagonists; Aged; Allosteric Regulation; Clonidine; Corpus Striatum; Female; Humans; Idazoxan; Imidazoline Receptors; Male; Middle Aged; Receptors, Drug; Structure-Activity Relationship | 1997 |
Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Cattle; Clonidine; Idazoxan; Imidazoles; Magnesium; Male; Manganese; Medetomidine; Membranes; Radioligand Assay; Rats; Reproducibility of Results; Retina; Sensitivity and Specificity; Tritium | 1997 |
Characterisation of pre- and post-synaptic alpha-adrenoceptors in modulation of the rat ileum longitudinal and circular muscle activities.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding Sites; Brimonidine Tartrate; Clonidine; Electric Stimulation; Idazoxan; Ileum; In Vitro Techniques; Muscle Contraction; Oxymetazoline; Phentolamine; Quinoxalines; Rats; Receptors, Adrenergic, alpha; Receptors, Presynaptic | 1997 |
Selective increase of alpha2A-adrenoceptor agonist binding sites in brains of depressed suicide victims.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adult; Autoradiography; Binding, Competitive; Brain Chemistry; Brimonidine Tartrate; Cell Membrane; Clonidine; Depression; Female; Frontal Lobe; Humans; Idazoxan; Male; Middle Aged; Quinoxalines; Receptors, Adrenergic, alpha-2; Suicide; Tritium | 1998 |
Antagonist precipitated clonidine withdrawal in rat: effects on locus coeruleus neurons, sympathetic nerves and cardiovascular parameters.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Inhalation; Animals; Blood Pressure; Cardiovascular System; Clonidine; Consciousness; Halothane; Heart Rate; Idazoxan; Imidazoles; Locus Coeruleus; Male; Neurons; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Substance Withdrawal Syndrome; Sympathetic Nervous System; Sympatholytics; Vascular Resistance | 1998 |
The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception.
Topics: Abdominal Pain; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Idazoxan; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Nefopam; Pain Measurement; Receptors, Adrenergic; Receptors, Opioid | 1999 |
Clonidine evokes vasodepressor responses via alpha2-adrenergic receptors in gigantocellular reticular formation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Depression, Chemical; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Idazoxan; Male; Medulla Oblongata; Microinjections; Neurons; Prazosin; Rats; Rats, Sprague-Dawley; Reticular Formation | 1999 |
Determination of the somatodendritic alpha2-adrenoceptor subtype located in rat locus coeruleus that modulates cortical noradrenaline release in vivo.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anesthesia; Animals; Brimonidine Tartrate; Cerebral Cortex; Chromatography, High Pressure Liquid; Clonidine; Dendritic Cells; Drug Interactions; Idazoxan; Imidazoles; Indoles; Isoindoles; Isoquinolines; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Time Factors | 1999 |
Antagonistic effect of N-methyltyramine on alpha2-adrenoceptor in mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Idazoxan; Male; Mice; Radioligand Assay; Receptors, Adrenergic, alpha-2; Scopolamine; Tyramine | 1999 |
Synthesis and alpha-adrenergic binding ligand affinities of 2-iminoimidazolidine derivatives.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Clonidine; Idazoxan; Imidazoles; In Vitro Techniques; Ligands; Magnetic Resonance Spectroscopy; Prazosin; Rats; Receptors, Adrenergic, alpha-2; Spectrophotometry, Infrared; Yohimbine | 2000 |
A further characterization of alpha-2 adrenoceptor involvement in the rough-and-tumble play of juvenile rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Clonidine; Idazoxan; Male; Norepinephrine; Play and Playthings; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 2000 |
Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic alpha2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Clonidine; Desipramine; Dose-Response Relationship, Drug; Extracellular Space; Hippocampus; Idazoxan; Locus Coeruleus; Male; Microdialysis; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Presynaptic; Synaptosomes; Time Factors; Tritium | 2001 |
Brain alpha(2)-adrenoceptors in monoamine-depleted rats: increased receptor density, G coupling proteins, receptor turnover and receptor mRNA.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Binding, Competitive; Brain; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Epinephrine; Gene Expression Regulation; GTP-Binding Proteins; Idazoxan; Male; Membranes; Norepinephrine; Quinolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reserpine; RNA, Messenger; Tritium | 2001 |
Alpha2A-adrenoceptor mediated tachypnea in awake goats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Goats; Guanfacine; Heart Rate; Idazoxan; Periodicity; Receptors, Adrenergic, alpha-2; Respiratory Mechanics | 2001 |
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Catheterization; Clonidine; Drug Interactions; Ethanol; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug | 2001 |
Effects of medullary alpha2-adrenoceptor blockade in the rat.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Idazoxan; Injections, Intravenous; Injections, Intraventricular; Kidney; Male; Medulla Oblongata; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Solitary Nucleus; Sympathetic Nervous System | 2002 |
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 2003 |
Clonidine increases caspase-3 mRNA level and DNA fragmentation in the developing rat brainstem.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aging; Animals; Animals, Newborn; Binding, Competitive; Brain Stem; Caspase 3; Caspases; Cell Differentiation; Clonidine; DNA Fragmentation; Female; Idazoxan; Male; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; RNA, Messenger; Up-Regulation | 2004 |
Long-lasting effects of yohimbine on the ejaculatory function in male dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dogs; Ejaculation; Idazoxan; Male; Penile Erection; Sexual Behavior, Animal; Time Factors; Yohimbine | 2005 |
Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Animals; Base Sequence; Brain; Clonidine; DNA Primers; Idazoxan; Mice; Mice, Knockout; Norepinephrine Plasma Membrane Transport Proteins; Polymerase Chain Reaction; Receptors, Adrenergic, alpha-2; RNA, Messenger | 2006 |
α2-adrenergic drugs modulate the binding of [18F]fallypride to dopamine D2/3 receptors in striatum of living mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzamides; Binding, Competitive; Brain Mapping; Clonidine; Corpus Striatum; Dopamine; Female; Idazoxan; Mice; Mice, Inbred BALB C; Positron-Emission Tomography; Pyrrolidines; Receptors, Adrenergic, alpha-2; Receptors, Dopamine D2; Yohimbine | 2010 |
Adrenergic receptors modulate motoneuron excitability, sensory synaptic transmission and muscle spasms after chronic spinal cord injury.
Topics: Adrenergic Agonists; Adrenergic Antagonists; Animals; Chromones; Clonidine; Excitatory Postsynaptic Potentials; Female; Idazoxan; Models, Animal; Motor Neurons; Norepinephrine; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Sensory Receptor Cells; Spasm; Spinal Cord Injuries; Synaptic Transmission | 2011 |
The function of alpha-2-adrenoceptors in the rat locus coeruleus is preserved in the chronic constriction injury model of neuropathic pain.
Topics: Action Potentials; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Brimonidine Tartrate; Clonidine; Desipramine; Disease Models, Animal; Idazoxan; Locus Coeruleus; Male; MAP Kinase Signaling System; Medulla Oblongata; Neuralgia; Norepinephrine; Prefrontal Cortex; Quinoxalines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Signal Transduction; Spinal Cord | 2012 |
The α₁-, but not α₂-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Clonidine; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Idazoxan; Male; Methoxamine; Movement; Neurons; Norepinephrine; Nucleus Accumbens; Prazosin; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2 | 2012 |
Responsiveness of α2-adrenoceptor/I1-imidazoline receptor in the rostral ventrolateral medulla to cardiovascular regulation is enhanced in conscious spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Blood Pressure Determination; Clonidine; Consciousness; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System | 2019 |