rx 821002 has been researched along with brimonidine in 4 studies
| Studies (rx 821002) | Trials (rx 821002) | Recent Studies (post-2010) (rx 821002) | Studies (brimonidine) | Trials (brimonidine) | Recent Studies (post-2010) (brimonidine) |
|---|---|---|---|---|---|
| 317 | 0 | 45 | 40 | 0 | 16 |
| Protein | Taxonomy | rx 821002 (IC50) | brimonidine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.1505 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.525 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.003 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 2.551 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.72 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 2.551 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harms, GS; Lohse, MJ; Steinmeyer, R; Vilardaga, JP | 1 |
| Callado, LF; Meana, JJ; Ortega, JE; Rodriguez, F; Rozas, I | 1 |
| Callado, LF; Erdozain, AM; Meana, JJ; Ortega, JE; Rodriguez, F; Rozas, I | 2 |
4 other study(ies) available for rx 821002 and brimonidine
| Article | Year |
|---|---|
Molecular basis of inverse agonism in a G protein-coupled receptor.
Topics: Adrenergic alpha-2 Receptor Agonists; Cell Line; Fluorescence Resonance Energy Transfer; Humans; Ligands; Protein Binding; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Signal Transduction | 2005 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha(2)-adrenoceptor antagonists, 1: toward new antidepressants with heteroatomic linkers.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents; Binding, Competitive; Blood-Brain Barrier; Brain; Guanidines; Humans; Imidazolines; In Vitro Techniques; Male; Microdialysis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship | 2007 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor antagonists. 2. Exploring alkyl linkers for new antidepressants.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents; Blood-Brain Barrier; Brain; Guanidines; Humans; Imidazoles; Imidazolines; In Vitro Techniques; Male; Microdialysis; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stilbenes; Structure-Activity Relationship; Tetrahydronaphthalenes | 2008 |
Guanidine and 2-aminoimidazoline aromatic derivatives as alpha2-adrenoceptor ligands: searching for structure-activity relationships.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Brimonidine Tartrate; Guanidines; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Imidazoles; Microdialysis; Neurons; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 2009 |