Page last updated: 2024-09-02

rx 821002 and atipamezole

rx 821002 has been researched along with atipamezole in 11 studies

Compound Research Comparison

Studies
(rx 821002)
Trials
(rx 821002)
Recent Studies (post-2010)
(rx 821002)
Studies
(atipamezole)
Trials
(atipamezole)
Recent Studies (post-2010) (atipamezole)
31704553064143

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (72.73)18.2507
2000's2 (18.18)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Durcan, MJ; Linnoila, M; Lister, RG1
Berlan, M; Galitzky, J; Montastruc, P; Tran, MA1
Goodwin, WB; Guyenet, PG; Huangfu, D1
Halme, M; Savola, JM; Scheinin, M; Sjöholm, B1
Audinot, V; Chaput, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Nicolas, JP; Richard, N; Touzard, M; Verrièle, L1
Baertschi, AJ; Grubb, MC; Guyenet, PG; Pence, R; Stornetta, RL1
Heal, DJ; Stanford, SC; Wortley, KE1
Hillilä, M; Lähdesmäki, J; Pyykkö, K; Scheinin, M; Sjöholm, B1
Clarke, RW; Eves, S; Harris, J; Peachey, JE; Stuart, E1
Pauwels, PJ; Tardif, S1
Galizzi, JP; Lockhart, B; Millan, MJ; Rivet, JM; Rodriguez, M; Serres, F; Sharp, T1

Other Studies

11 other study(ies) available for rx 821002 and atipamezole

ArticleYear
Evidence for central alpha-2 adrenoceptors, not imidazoline binding sites, mediating the ethanol-attenuating properties of alpha-2 adrenoceptor antagonists.
    The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Ataxia; Body Temperature; Brain; Dioxanes; Ethanol; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Mice; Motor Activity; Quinolizines; Receptors, Adrenergic, alpha; Receptors, Drug

1991
Anorectic effect of alpha 2-antagonists in dog: effect of acute and chronic treatment.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 39, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Blood Glucose; Blood Platelets; Body Weight; Catecholamines; Cell Membrane; Dioxanes; Dogs; Fatty Acids, Nonesterified; Feeding Behavior; Idazoxan; Imidazoles; Insulin; Male; Nadolol; Yohimbine

1991
Sympatholytic effect of tricyclic antidepressants: site and mechanism of action in anesthetized rats.
    The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 2

    Topics: Adrenergic alpha-Antagonists; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Baclofen; Blood Pressure; Brain Mapping; Desipramine; Dioxanes; Fluoxetine; gamma-Aminobutyric Acid; Idazoxan; Imidazoles; Male; Medulla Oblongata; Microinjections; Nordefrin; Oxidopamine; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Sympatholytics; Time Factors

1995
Recombinant human alpha 2-adrenoceptor subtypes: comparison of [3H]rauwolscine, [3H]atipamezole and [3H]RX821002 as radioligands.
    Biochimica et biophysica acta, 1995, Apr-28, Volume: 1266, Issue:2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding, Competitive; Buffers; Cell Line; Dioxanes; Humans; Idazoxan; Imidazoles; Kinetics; Mice; Radioligand Assay; Recombinant Proteins; Yohimbine

1995
Actions of alpha2 adrenoceptor ligands at alpha2A and 5-HT1A receptors: the antagonist, atipamezole, and the agonist, dexmedetomidine, are highly selective for alpha2A adrenoceptors.
    Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 358, Issue:2

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Brimonidine Tartrate; CHO Cells; Cricetinae; Guanfacine; Humans; Idazoxan; Imidazoles; Ligands; Medetomidine; Quinoxalines; Radioligand Assay; Rats; Receptors, Adrenergic, alpha-2; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Yohimbine

1998
Antagonist precipitated clonidine withdrawal in rat: effects on locus coeruleus neurons, sympathetic nerves and cardiovascular parameters.
    Journal of the autonomic nervous system, 1998, Jul-15, Volume: 71, Issue:2-3

    Topics: Adrenergic alpha-Antagonists; Anesthesia; Anesthetics, Inhalation; Animals; Blood Pressure; Cardiovascular System; Clonidine; Consciousness; Halothane; Heart Rate; Idazoxan; Imidazoles; Locus Coeruleus; Male; Neurons; Rats; Rats, Sprague-Dawley; Splanchnic Nerves; Substance Withdrawal Syndrome; Sympathetic Nervous System; Sympatholytics; Vascular Resistance

1998
Modulation of sibutramine-induced increases in extracellular noradrenaline concentration in rat frontal cortex and hypothalamus by alpha2-adrenoceptors.
    British journal of pharmacology, 1999, Volume: 128, Issue:3

    Topics: Adrenergic alpha-Antagonists; Animals; Appetite Depressants; Cyclobutanes; Dialysis; Frontal Lobe; Hypothalamus; Idazoxan; Imidazoles; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2

1999
Non-adrenergic binding of [3H]atipamezole in rat kidney--regional distribution and comparison to alpha2-adrenoceptors.
    British journal of pharmacology, 1999, Volume: 128, Issue:6

    Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Female; Idazoxan; Imidazoles; Kidney; Male; Membranes; Monoamine Oxidase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2; Tritium; Yohimbine

1999
Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems.
    Neuroscience, 2002, Volume: 112, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Afferent Pathways; Animals; Decerebrate State; Dexmedetomidine; Dizocilpine Maleate; Drug Synergism; Efferent Pathways; Electric Stimulation; Excitatory Amino Acid Antagonists; Idazoxan; Imidazoles; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Neurons, Afferent; Rabbits; Reflex; Skin; Sural Nerve; Tarsus, Animal

2002
Enhanced stability of wild-type and constitutively active alpha(2A)-adrenoceptors by ligands with agonist, silent and inverse agonist properties.
    Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:2

    Topics: Adrenergic alpha-Antagonists; Animals; Binding Sites; CHO Cells; Cricetinae; Drug Interactions; GTP-Binding Proteins; Guanosine Triphosphate; Idazoxan; Imidazoles; Protein Binding; Radioligand Assay; Receptors, Adrenergic, alpha-2; Time Factors; Transfection; Up-Regulation

2002
Blockade of α2-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: a combined qPCR, in situ hybridisation and immunocytochemistry study.
    Neuropharmacology, 2012, Volume: 63, Issue:6

    Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Brain Chemistry; Cytoskeletal Proteins; Excitatory Amino Acid Antagonists; Idazoxan; Image Processing, Computer-Assisted; Imidazoles; Immunohistochemistry; In Situ Hybridization; Male; Nerve Tissue Proteins; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Glutamate; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; RNA; Serotonin

2012