rutin and 6-hydroxy-2-5-7-8-tetramethylchroman-2-carboxylic-acid

rutin has been researched along with 6-hydroxy-2-5-7-8-tetramethylchroman-2-carboxylic-acid* in 2 studies

Other Studies

2 other study(ies) available for rutin and 6-hydroxy-2-5-7-8-tetramethylchroman-2-carboxylic-acid

Article	Year
A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox. Bioorganic & medicinal chemistry letters, 2014, Mar-01, Volume: 24, Issue:5 Edaravone (3-methyl-1-phenyl-2-pyrazoline-5-one) is a neuroprotective drug that has been used for brain ischemia injury treatment. Because its activity is speculated to be due to free radical scavenging activity, we carried out a quantitative determination of edaravone's free radical scavenging activity against multiple free radical species. Electron spin resonance (ESR) spin trapping-based multiple free-radical scavenging (MULTIS) method was employed, where target free radicals were hydroxyl radical, superoxide anion, alkoxyl radical, alkylperoxyl radical, methyl radical, and singlet oxygen. Edaravone showed relatively high scavenging abilities against hydroxyl radical (scavenging rate constant k=2.98×10(11) M(-1) s(-1)), singlet oxygen (k=2.75×10(7) M(-1) s(-1)), and methyl radical (k=3.00×10(7) M(-1) s(-1)). Overall, edaravone's scavenging activity against multiple free radical species is as robust as other known potent antioxidant such as uric acid, glutathione, and trolox. A radar chart illustration of the MULTIS activity relative to uric acid, glutathione, and trolox indicates that edaravone has a high and balanced antioxidant activity with low specificity. Topics: Antipyrine; Chromans; Edaravone; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Glutathione; Neuroprotective Agents; Uric Acid	2014
Antioxidant principles from Bauhinia tarapotensis. Journal of natural products, 2001, Volume: 64, Issue:7 A new cyclohexenone (1) and a new caffeoyl ester derivative (2), together with the known compounds (-)-isolariciresinol 3-alpha-O-beta-D-glucopyranoside (3), (+)-1-hydroxypinoresinol 1-O-beta-D-glucopyranoside (4), isoacteoside (5), luteolin 4'-O-beta-D-glucopyranoside (6), and indole-3-carboxylic acid (7), were isolated from the leaves of Bauhinia tarapotensis. The structures of these new compounds were determined by spectroscopic data analysis. The antioxidant activities of 1-7 were determined by measuring their free radical scavenging effects, using the 1,1-diphenyl-2-dipicrylhydrazyl free radical (DPPH) and Trolox equivalent antioxidant activity (TEAC) methods, and the coupled oxidation of beta-carotene and linoleic acid. Compounds 3-5 showed good activities in the DPPH and TEAC tests, while compounds 1 and 2 were active in the coupled oxidation of beta-carotene and linoleic acid bioassay. Topics: Antioxidants; Benzothiazoles; Bepridil; Biphenyl Compounds; Caffeic Acids; Chromans; Chromatography, High Pressure Liquid; Cyclohexanones; Ecuador; Fabaceae; Flavonoids; Free Radical Scavengers; Glucosides; Indoles; Luteolin; Magnetic Resonance Spectroscopy; Molecular Structure; Phenols; Picrates; Plant Leaves; Plants, Medicinal; Sulfonic Acids	2001

Article

Year

A multiple free-radical scavenging (MULTIS) study on the antioxidant capacity of a neuroprotective drug, edaravone as compared with uric acid, glutathione, and trolox.

Bioorganic & medicinal chemistry letters, 2014, Mar-01, Volume: 24, Issue:5

Edaravone (3-methyl-1-phenyl-2-pyrazoline-5-one) is a neuroprotective drug that has been used for brain ischemia injury treatment. Because its activity is speculated to be due to free radical scavenging activity, we carried out a quantitative determination of edaravone's free radical scavenging activity against multiple free radical species. Electron spin resonance (ESR) spin trapping-based multiple free-radical scavenging (MULTIS) method was employed, where target free radicals were hydroxyl radical, superoxide anion, alkoxyl radical, alkylperoxyl radical, methyl radical, and singlet oxygen. Edaravone showed relatively high scavenging abilities against hydroxyl radical (scavenging rate constant k=2.98×10(11) M(-1) s(-1)), singlet oxygen (k=2.75×10(7) M(-1) s(-1)), and methyl radical (k=3.00×10(7) M(-1) s(-1)). Overall, edaravone's scavenging activity against multiple free radical species is as robust as other known potent antioxidant such as uric acid, glutathione, and trolox. A radar chart illustration of the MULTIS activity relative to uric acid, glutathione, and trolox indicates that edaravone has a high and balanced antioxidant activity with low specificity.

Topics: Antipyrine; Chromans; Edaravone; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Free Radicals; Glutathione; Neuroprotective Agents; Uric Acid

2014

Antioxidant principles from Bauhinia tarapotensis.

Journal of natural products, 2001, Volume: 64, Issue:7

A new cyclohexenone (1) and a new caffeoyl ester derivative (2), together with the known compounds (-)-isolariciresinol 3-alpha-O-beta-D-glucopyranoside (3), (+)-1-hydroxypinoresinol 1-O-beta-D-glucopyranoside (4), isoacteoside (5), luteolin 4'-O-beta-D-glucopyranoside (6), and indole-3-carboxylic acid (7), were isolated from the leaves of Bauhinia tarapotensis. The structures of these new compounds were determined by spectroscopic data analysis. The antioxidant activities of 1-7 were determined by measuring their free radical scavenging effects, using the 1,1-diphenyl-2-dipicrylhydrazyl free radical (DPPH) and Trolox equivalent antioxidant activity (TEAC) methods, and the coupled oxidation of beta-carotene and linoleic acid. Compounds 3-5 showed good activities in the DPPH and TEAC tests, while compounds 1 and 2 were active in the coupled oxidation of beta-carotene and linoleic acid bioassay.

Topics: Antioxidants; Benzothiazoles; Bepridil; Biphenyl Compounds; Caffeic Acids; Chromans; Chromatography, High Pressure Liquid; Cyclohexanones; Ecuador; Fabaceae; Flavonoids; Free Radical Scavengers; Glucosides; Indoles; Luteolin; Magnetic Resonance Spectroscopy; Molecular Structure; Phenols; Picrates; Plant Leaves; Plants, Medicinal; Sulfonic Acids

2001