Page last updated: 2024-08-22

ruthenium and indazoles

ruthenium has been researched along with indazoles in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (8.11)	18.2507
2000's	4 (10.81)	29.6817
2010's	23 (62.16)	24.3611
2020's	7 (18.92)	2.80

Authors

Authors	Studies
Berger, MR; Keppler, BK; Seelig, MH	1
Frühauf, S; Zeller, WJ	1
Hartmann, M; Keppler, B; Kratz, F; Messori, L	1
Arion, VB; Eichinger, A; Guedes da Silva, MF; Keppler, BK; Kukushkin, VY; Lichtenecker, R; Pombeiro, AJ; Reisner, E	1
Berger, W; Heffeter, P; Jakupec, MA; Kapitza, S; Keppler, BK; Lackinger, L; Marian, B; Pongratz, M	1
Arion, VB; Chiorescu, I; Keppler, BK; Reisner, E; Rufińska, A; Schmid, WF	1
Groessl, M; Hann, S; Hartinger, CG; Keppler, BK; Koellensperger, G; Rudnev, AV; Stingeder, G; Sulyok, M; Timerbaev, AR	1
Silva, Dde O	1
Dyson, PJ; Groessl, M; Zava, O	1
Bartel, C; Berger, W; Egger, AE; Galanski, MS; Heffeter, P; Jakupec, MA; Keppler, BK	1
Boeck, K; Bytzek, AK; Hann, S; Hartinger, CG; Hermann, G; Keppler, BK; Koellensperger, G	1
Bytzek, AK; Dömötör, O; Enyedy, EA; Hartinger, CG; Keppler, BK; Kiss, T	1
Bruce, I	1
Lin, WC; Yang, DY	1
Walsby, CJ; Webb, MI	1
Chard, RA; Jang, T; Walsby, CJ; Webb, MI; Wong, EW; Wong, MQ; Wu, B; Yapp, DT	1
Jarosz, M; Matczuk, M; Pawlak, K; Timerbaev, AR	1
Aquilante, F; Delcey, MG; Freitag, L; González, L; Keller, SF; Knecht, S; Lindh, R; Pedersen, TB; Reiher, M	1
Costa, PP; Fernandes, AF; Fonteles, MC; Lopes, LG; Nascimento, NR; Sá, DS; Silva, CD; Sousa, EH	1
Arion, VB; Bačić, G; Dömötör, O; Enyedy, EA; Kuhn, PS; Popović-Bijelić, A; Rathgeb, A	1
Alessio, E; Arcangeli, A; Balducci, G; Battistin, F; Messori, L; Pillozzi, S; Scaletti, F	1
Bytzek, AK; G Hartinger, C; Keppler, BK; Koellensperger, G	1
Garcia, MH; Marques, F; Morais, TS; Tomaz, AI; Valente, A	1
Bally, MB; Chang, SW; Gladkikh, M; Lewis, AR; Prosser, KE; Thompson, JR; Walsby, CJ; Warren, JJ	1
Glover, CJ; Gransbury, GK; Harris, HH; Hughes, JN; Kappen, P; Lay, PA; Levina, A; Musgrave, IF	1
Arion, VB; Büchel, GE; Bucinsky, L; Eppinger, J; Komorovsky, S; Kossatz, S; Rapta, P; Reiner, T; Sadique, A; Telser, J; Zalibera, M	1
Dhole, S; Selvaraju, M; Sun, CM; Wu, TY	1
Cazares, E; Dwyer, BG; Johnson, E; Kirk, SR; McFarlane Holman, KL	1
Gou, S; Li, S; Li, W; Lin, S; Wei, Q; Xu, G; Zhao, J	1
Ang, WH; Arion, VB; Babak, MV; Bučinský, L; Dömötör, O; Enyedy, EA; Farid, YCS; Govind, C; Karunakaran, V; Luneau, D; Malček, M; McDonnell, TE; Orlowska, E; Rapta, P; Schaniel, D; Zalibera, M	1
Blatt, E; Grovenstein, E; Hanson, PK; Hunsucker, A; Middleton, S; Miller, M; Mobley, J; O'Leary, J; Stultz, LK	1
Balamurali, MM; Chanda, K; Manickam, V; Panchangam, RL; Rao, RN	1
Biniak, S; Cieślak, MJ; Kaźmierczak-Barańska, J; Królewska-Golińska, K; Richert, M; Sobczak, JW; Trykowski, G; Walczyk, M	1
Das, U; Kar, B; Paira, P; Pete, S	1
Babkov, DA; Gracheva, YA; Kirsanov, KI; Milaeva, ER; Nazarov, AA; Okulova, YN; Ott, I; Redkozubova, OM; Schmidt, C; Shevtsova, EF; Shtil, AA; Shutkov, IA; Sokolova, EV; Spasov, AA; Tyurin, VY	1
Jena, NR; Shah, PK; Shukla, PK	1
Chetcuti, ARM; Lay, PA; Levina, A	1

Reviews

2 review(s) available for ruthenium and indazoles

Article	Year
Perspectives for novel mixed diruthenium-organic drugs as metallopharmaceuticals in cancer therapy. Anti-cancer agents in medicinal chemistry, 2010, Volume: 10, Issue:4 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Dimethyl Sulfoxide; Glioblastoma; Humans; Indazoles; Ligands; Neoplasms; Organometallic Compounds; Organoplatinum Compounds; Rats; Ruthenium; Ruthenium Compounds; Solubility	2010
Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds. Future medicinal chemistry, 2016, Volume: 8, Issue:5 Topics: Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Cyclopentanes; Dimethyl Sulfoxide; Drug Discovery; Ferrous Compounds; Humans; Indazoles; Molecular Targeted Therapy; Neoplasms; Organometallic Compounds; Protein Binding; Ruthenium; Ruthenium Compounds	2016

Article

Year

Perspectives for novel mixed diruthenium-organic drugs as metallopharmaceuticals in cancer therapy.

Anti-cancer agents in medicinal chemistry, 2010, Volume: 10, Issue:4

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Dimethyl Sulfoxide; Glioblastoma; Humans; Indazoles; Ligands; Neoplasms; Organometallic Compounds; Organoplatinum Compounds; Rats; Ruthenium; Ruthenium Compounds; Solubility

2010

Tracking antitumor metallodrugs: promising agents with the Ru(II)- and Fe(II)-cyclopentadienyl scaffolds.

Future medicinal chemistry, 2016, Volume: 8, Issue:5

Topics: Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Cyclopentanes; Dimethyl Sulfoxide; Drug Discovery; Ferrous Compounds; Humans; Indazoles; Molecular Targeted Therapy; Neoplasms; Organometallic Compounds; Protein Binding; Ruthenium; Ruthenium Compounds

2016

Other Studies

35 other study(ies) available for ruthenium and indazoles

Article	Year
Antineoplastic activity of three ruthenium derivatives against chemically induced colorectal carcinoma in rats. Journal of cancer research and clinical oncology, 1992, Volume: 118, Issue:3 Topics: Animals; Antineoplastic Agents; Body Weight; Carcinoma; Colorectal Neoplasms; Dose-Response Relationship, Drug; Imidazoles; Indazoles; Male; Organometallic Compounds; Rats; Rats, Inbred Strains; Ruthenium	1992
New platinum, titanium, and ruthenium complexes with different patterns of DNA damage in rat ovarian tumor cells. Cancer research, 1991, Jun-01, Volume: 51, Issue:11 Topics: Animals; Crown Ethers; DNA, Neoplasm; Drug Screening Assays, Antitumor; Ethers, Cyclic; Ethylnitrosourea; Female; Indazoles; Organometallic Compounds; Organophosphorus Compounds; Organoplatinum Compounds; Ovarian Neoplasms; Rats; Ruthenium; Titanium	1991
The binding properties of two antitumor ruthenium(III) complexes to apotransferrin. The Journal of biological chemistry, 1994, Jan-28, Volume: 269, Issue:4 Topics: Antineoplastic Agents; Apoproteins; Chromatography, High Pressure Liquid; Humans; Imidazoles; Indazoles; Magnetic Resonance Spectroscopy; Molecular Structure; Organometallic Compounds; Protein Binding; Ruthenium; Spectrophotometry; Transferrin	1994
Tuning of redox potentials for the design of ruthenium anticancer drugs -- an electrochemical study of [trans-RuCl(4)L(DMSO)](-) and [trans-RuCl(4)L(2)](-) complexes, where L = imidazole, 1,2,4-triazole, indazole. Inorganic chemistry, 2004, Nov-01, Volume: 43, Issue:22 Topics: Antineoplastic Agents; Dimethyl Sulfoxide; Drug Design; Electrochemistry; Imidazoles; Indazoles; Molecular Conformation; Molecular Structure; Organometallic Compounds; Oxidation-Reduction; Ruthenium; Stereoisomerism; Triazoles	2004
Heterocyclic complexes of ruthenium(III) induce apoptosis in colorectal carcinoma cells. Journal of cancer research and clinical oncology, 2005, Volume: 131, Issue:2 Topics: Apoptosis; Carcinoma; Colorectal Neoplasms; Humans; Indazoles; Mitochondria; Organometallic Compounds; Ruthenium; Salts; Tumor Cells, Cultured	2005
Isomeric [RuCl2(dmso)2(indazole)2] complexes: ruthenium(II)-mediated coupling reaction of acetonitrile with 1H-indazole. Dalton transactions (Cambridge, England : 2003), 2005, Jul-21, Issue:14 Topics: Acetonitriles; Antineoplastic Agents; Carbon; Cations, Divalent; Crystallography, X-Ray; Electrochemistry; Indazoles; Isomerism; Ligands; Molecular Conformation; Nitrogen; Organometallic Compounds; Ruthenium; Spectrum Analysis	2005
Interactions of a novel ruthenium-based anticancer drug (KP1019 or FFC14a) with serum proteins--significance for the patient. International journal of clinical pharmacology and therapeutics, 2005, Volume: 43, Issue:12 Topics: Albumins; Antineoplastic Agents; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Humans; Indazoles; Neoplasms; Organometallic Compounds; Protein Binding; Ruthenium; Ruthenium Compounds; Spectrometry, Mass, Electrospray Ionization; Transferrin	2005
Cellular uptake and subcellular distribution of ruthenium-based metallodrugs under clinical investigation versus cisplatin. Metallomics : integrated biometal science, 2011, Volume: 3, Issue:6 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cisplatin; Cytosol; Dimethyl Sulfoxide; DNA; DNA Adducts; Humans; Indazoles; Inhibitory Concentration 50; Mass Spectrometry; Mitochondria; Molecular Structure; Organometallic Compounds; Ruthenium; Ruthenium Compounds; Time Factors	2011
Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2011, Volume: 16, Issue:8 Topics: Antineoplastic Agents; Ascorbic Acid; Cell Survival; DNA; Drug Synergism; Drugs, Investigational; Humans; Indazoles; KB Cells; Magnetic Resonance Spectroscopy; Organometallic Compounds; Protein Binding; Reactive Oxygen Species; Ruthenium; Ruthenium Compounds; Tumor Cells, Cultured	2011
LC- and CZE-ICP-MS approaches for the in vivo analysis of the anticancer drug candidate sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] (KP1339) in mouse plasma. Metallomics : integrated biometal science, 2011, Volume: 3, Issue:10 Topics: Animals; Antineoplastic Agents; Chromatography, Gel; Electrophoresis, Capillary; Indazoles; Limit of Detection; Mass Spectrometry; Mice; Organometallic Compounds; Protein Binding; Ruthenium; Serum Albumin	2011
Characterization of the binding sites of the anticancer ruthenium(III) complexes KP1019 and KP1339 on human serum albumin via competition studies. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2013, Volume: 18, Issue:1 Topics: Antineoplastic Agents; Bilirubin; Binding, Competitive; Heme; Humans; Indazoles; Organometallic Compounds; Ruthenium; Ruthenium Compounds; Serum Albumin; Spectrometry, Fluorescence	2013
System and compound enjoy budding relationship. Future medicinal chemistry, 2013, Volume: 5, Issue:2 Topics: Animals; Antineoplastic Agents; Clinical Trials, Phase I as Topic; Humans; Indazoles; Organometallic Compounds; Ruthenium; Ruthenium Compounds; Saccharomyces cerevisiae	2013
Visible light photoredox catalysis: synthesis of indazolo[2,3-a]quinolines from 2-(2-nitrophenyl)-1,2,3,4-tetrahydroquinolines. Organic letters, 2013, Sep-20, Volume: 15, Issue:18 Topics: Aniline Compounds; Catalysis; Cyclization; Indazoles; Light; Molecular Structure; Quinolines; Ruthenium; Stereoisomerism	2013
EPR as a probe of the intracellular speciation of ruthenium(III) anticancer compounds. Metallomics : integrated biometal science, 2013, Volume: 5, Issue:12 Topics: Antineoplastic Agents; Dimethyl Sulfoxide; Electron Spin Resonance Spectroscopy; Indazoles; Organometallic Compounds; Oxidation-Reduction; Ruthenium; Ruthenium Compounds; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins	2013
Increasing the bioavailability of Ru(III) anticancer complexes through hydrophobic albumin interactions. Chemistry (Weinheim an der Bergstrasse, Germany), 2013, Dec-09, Volume: 19, Issue:50 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Humans; Hydrophobic and Hydrophilic Interactions; Indazoles; Ligands; Molecular Structure; Organometallic Compounds; Ruthenium; Ruthenium Compounds; Serum Albumin	2013
Molecular mass spectrometry in metallodrug development: a case of mapping transferrin-mediated transformations for a ruthenium(III) anticancer drug. Analytica chimica acta, 2014, Dec-03, Volume: 851 Topics: Antineoplastic Agents; Biological Transport; Biotransformation; Coordination Complexes; Drug Discovery; Indazoles; Models, Molecular; Molecular Weight; Organometallic Compounds; Protein Conformation; Ruthenium; Spectrometry, Mass, Electrospray Ionization; Transferrin	2014
Orbital entanglement and CASSCF analysis of the Ru-NO bond in a Ruthenium nitrosyl complex. Physical chemistry chemical physics : PCCP, 2015, Jun-14, Volume: 17, Issue:22 Topics: Algorithms; Binding Sites; Cations; Computer Simulation; Indazoles; Models, Chemical; Molecular Docking Simulation; Nitric Oxide; Numerical Analysis, Computer-Assisted; Organometallic Compounds; Quantum Theory; Ruthenium; Ruthenium Compounds	2015
Non-nitric oxide based metallovasodilators: synthesis, reactivity and biological studies. Dalton transactions (Cambridge, England : 2003), 2015, Aug-14, Volume: 44, Issue:30 Topics: 2,2'-Dipyridyl; Animals; Aorta; Aza Compounds; Benzimidazoles; Cell Line; Humans; Indazoles; Indoles; Organometallic Compounds; Quinolines; Rats; Ruthenium; Superoxides; Vasodilation; Vasodilator Agents	2015
Investigation of the binding of cis/trans-[MCl4(1H-indazole)(NO)](-) (M = Ru, Os) complexes to human serum albumin. Journal of inorganic biochemistry, 2016, Volume: 159 Topics: Humans; Indazoles; Organometallic Compounds; Osmium; Ruthenium; Serum Albumin	2016
Water-soluble Ru(II)- and Ru(III)-halide-PTA complexes (PTA=1,3,5-triaza-7-phosphaadamantane): Chemical and biological properties. Journal of inorganic biochemistry, 2016, Volume: 160 Topics: Adamantane; Antineoplastic Agents; Bromides; Cell Line, Tumor; Cell Survival; Chlorides; Coordination Complexes; Cytochromes c; Filaggrin Proteins; HCT116 Cells; Humans; Hydrogen-Ion Concentration; Imidazoles; Indazoles; Inhibitory Concentration 50; Ligands; Oligonucleotides; Organometallic Compounds; Organophosphorus Compounds; Protons; Ribonuclease, Pancreatic; Ruthenium; Solubility; Structure-Activity Relationship; Water	2016
Biodistribution of the novel anticancer drug sodium trans-[tetrachloridobis(1H-indazole)ruthenate(III)] KP-1339/IT139 in nude BALB/c mice and implications on its mode of action. Journal of inorganic biochemistry, 2016, Volume: 160 Topics: Animals; Antineoplastic Agents; Colon; Indazoles; Kidney; Liver; Lung; Mice; Mice, Inbred BALB C; Mice, Nude; Organ Specificity; Organometallic Compounds; Protein Binding; Ruthenium; Ruthenium Compounds; Serum Albumin; Thymus Gland; Tissue Distribution	2016
CF3 Derivatives of the Anticancer Ru(III) Complexes KP1019, NKP-1339, and Their Imidazole and Pyridine Analogues Show Enhanced Lipophilicity, Albumin Interactions, and Cytotoxicity. Inorganic chemistry, 2016, 05-16, Volume: 55, Issue:10 Topics: A549 Cells; Antineoplastic Agents; Coordination Complexes; Electrochemical Techniques; Electron Spin Resonance Spectroscopy; Fluorine Radioisotopes; HT29 Cells; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indazoles; Magnetic Resonance Spectroscopy; Organometallic Compounds; Pyridines; Ruthenium; Ruthenium Compounds; Serum Albumin; Solubility	2016
Comparison of KP1019 and NAMI-A in tumour-mimetic environments. Metallomics : integrated biometal science, 2016, 08-01, Volume: 8, Issue:8 Topics: Antineoplastic Agents; Dimethyl Sulfoxide; Humans; Hypoxia; Indazoles; Neuroblastoma; Organometallic Compounds; Ruthenium; Ruthenium Compounds; Spheroids, Cellular; Tumor Cells, Cultured; Tumor Microenvironment; X-Ray Absorption Spectroscopy	2016
cis-Tetrachlorido-bis(indazole)osmium(iv) and its osmium(iii) analogues: paving the way towards the cis-isomer of the ruthenium anticancer drugs KP1019 and/or NKP1339. Dalton transactions (Cambridge, England : 2003), 2017, Sep-12, Volume: 46, Issue:35 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Coordination Complexes; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; HEK293 Cells; HT29 Cells; Humans; Indazoles; Isomerism; Molecular Conformation; Organometallic Compounds; Osmium; Quantum Theory; Ruthenium; Ruthenium Compounds	2017
Regioselective Synthesis of Pyranone-Fused Indazoles via Reductive Cyclization and Alkyne Insertion. ACS combinatorial science, 2018, 03-12, Volume: 20, Issue:3 Topics: Alkynes; Benzylamines; Catalysis; Cyclization; Indazoles; Molecular Structure; Oxidation-Reduction; Pyrans; Ruthenium; Stereoisomerism; Zinc	2018
Ruthenium anticancer agent KP1019 binds more tightly than NAMI-A to tRNA Journal of inorganic biochemistry, 2018, Volume: 182 Topics: Antineoplastic Agents; Dimethyl Sulfoxide; Indazoles; Organometallic Compounds; RNA; RNA, Transfer, Phe; Ruthenium; Ruthenium Compounds	2018
Hypoxia-Targeting Organometallic Ru(II)-Arene Complexes with Enhanced Anticancer Activity in Hypoxic Cancer Cells. Inorganic chemistry, 2018, Jul-16, Volume: 57, Issue:14 Topics: Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Cisplatin; Coordination Complexes; Humans; Hydrophobic and Hydrophilic Interactions; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Ligands; Ruthenium	2018
NO Releasing and Anticancer Properties of Octahedral Ruthenium-Nitrosyl Complexes with Equatorial 1 H-Indazole Ligands. Inorganic chemistry, 2018, Sep-04, Volume: 57, Issue:17 Topics: Antineoplastic Agents; Blotting, Western; Cell Survival; Cisplatin; Drug Stability; Electrochemistry; HCT116 Cells; Humans; Indazoles; Inhibitory Concentration 50; Ligands; Models, Molecular; Nitric Oxide; Nitrogen Oxides; Organometallic Compounds; Quantum Theory; Ruthenium; Water; X-Ray Diffraction	2018
Proteomic analysis of the S. cerevisiae response to the anticancer ruthenium complex KP1019. Metallomics : integrated biometal science, 2020, 06-24, Volume: 12, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Indazoles; Organometallic Compounds; Oxaliplatin; Proteomics; Ruthenium; Ruthenium Compounds; Saccharomyces cerevisiae	2020
Synthesis and Antitumor Activity Evaluation of Cyclometalated 2H-Indazole Ruthenium(II) and Iridium(III) Complexes. ChemPlusChem, 2020, Volume: 85, Issue:8 Topics: Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Drug Screening Assays, Antitumor; Humans; Indazoles; Iridium; Ruthenium; Spectrum Analysis	2020
Modification of multiwalled carbon nanotubes with a ruthenium drug candidate-indazolium[tetrachlorobis(1 Dalton transactions (Cambridge, England : 2003), 2020, Dec-08, Volume: 49, Issue:46 Topics: A549 Cells; Antineoplastic Agents; Coordination Complexes; HeLa Cells; Humans; Indazoles; Nanotubes, Carbon; Ruthenium	2020
Ru(ii), Ir(iii), Re(i) and Rh(iii) based complexes as next generation anticancer metallopharmaceuticals. Dalton transactions (Cambridge, England : 2003), 2021, Aug-28, Volume: 50, Issue:32 Topics: Antineoplastic Agents; Coordination Complexes; Indazoles; Organometallic Compounds; Ruthenium; Ruthenium Compounds	2021
Ru(III) Complexes with Lonidamine-Modified Ligands. International journal of molecular sciences, 2021, Dec-15, Volume: 22, Issue:24 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Coordination Complexes; Drug Screening Assays, Antitumor; Humans; Indazoles; Ligands; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Oxidation-Reduction; Ruthenium; Structure-Activity Relationship; Thioredoxin-Disulfide Reductase	2021
Reactions of Ru(III)-drugs KP1019 and KP418 with guanine, 2'-deoxyguanosine and guanosine: a DFT study. Journal of molecular modeling, 2022, Sep-05, Volume: 28, Issue:10 Topics: Antineoplastic Agents; Deoxyguanosine; DNA; Guanine; Guanosine; Indazoles; Organometallic Compounds; RNA; Ruthenium; Ruthenium Compounds	2022
Controversial Role of Transferrin in the Transport of Ruthenium Anticancer Drugs. Biomolecules, 2022, 09-18, Volume: 12, Issue:9 Topics: Antineoplastic Agents; Ferric Compounds; Humans; Indazoles; Organometallic Compounds; Receptors, Transferrin; Ruthenium; Ruthenium Compounds; Serum Albumin; Transferrin	2022