rupatadine has been researched along with histamine in 9 studies
| Studies (rupatadine) | Trials (rupatadine) | Recent Studies (post-2010) (rupatadine) | Studies (histamine) | Trials (histamine) | Recent Studies (post-2010) (histamine) |
|---|---|---|---|---|---|
| 116 | 43 | 62 | 37,718 | 1,372 | 3,457 |
| Protein | Taxonomy | rupatadine (IC50) | histamine (IC50) |
|---|---|---|---|
| Histamine H1 receptor | Rattus norvegicus (Norway rat) | 0.1585 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.1585 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Barbanoj, MJ; García-Gea, C; Izquierdo, I; Jané, F; Morte, A; Pérez, I | 1 |
| Chliva, C; Clemons, A; House, M; Kalogeromitros, D; Kempuraj, D; Makris, M; Theoharides, TC; Vasiadi, M; Wolfberg, A; Zhang, B | 1 |
| Church, MK | 1 |
| Alevizos, M; Kalogeromitros, D; Karagkouni, A; Makris, M; Sismanopoulos, N; Theoharides, TC; Vasiadi, M | 1 |
| Dedi, H; Goulas, A; Kalokasidis, K; Karkavelas, G; Mirtsou, V; Molyva, D; Poulios, C | 1 |
| Antonijoan, R; Campo, C; Coimbra, J; García-Gea, C; Gich, I; Labeaga, L; Puntes, M; Valiente, R | 1 |
| Theoharides, TC | 1 |
| Mohamed, MZ; Mohammed, HH | 1 |
| Abdel Hafez, SMN; Abdel-Gaber, SA; Abdelmonaem, AA; Hafez, HM; Ibrahim, MA; Yehia Abdelzaher, W | 1 |
2 trial(s) available for rupatadine and histamine
| Article | Year |
|---|---|
Central and peripheral evaluation of rupatadine, a new antihistamine/platelet-activating factor antagonist, at different doses in healthy volunteers.
Topics: Adult; Analysis of Variance; Attention; Cross-Over Studies; Cyproheptadine; Decision Making; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Female; Flicker Fusion; Follow-Up Studies; Histamine; Histamine H1 Antagonists; Humans; Hydroxyzine; Male; Motor Activity; Neuropsychological Tests; Pain Measurement; Platelet Activating Factor; Psychomotor Performance; Reaction Time; Self-Assessment; Skin Tests; Statistics, Nonparametric; Time Factors | 2004 |
Comparative efficacy of bilastine, desloratadine and rupatadine in the suppression of wheal and flare response induced by intradermal histamine in healthy volunteers.
Topics: Adult; Benzimidazoles; Cross-Over Studies; Cyproheptadine; Double-Blind Method; Female; Healthy Volunteers; Histamine; Histamine Antagonists; Humans; Injections, Intradermal; Loratadine; Male; Piperidines; Skin | 2017 |
7 other study(ies) available for rupatadine and histamine
| Article | Year |
|---|---|
Rupatadine inhibits proinflammatory mediator secretion from human mast cells triggered by different stimuli.
Topics: Antibodies, Anti-Idiotypic; Cell Line, Tumor; Cells, Cultured; Cyproheptadine; Cytokines; Histamine; Histamine H1 Antagonists; Humans; Interleukin-1; Interleukin-4; Interleukin-6; Mast Cells; Stem Cell Factor; Substance P; Vascular Endothelial Growth Factor A | 2010 |
Efficacy and tolerability of rupatadine at four times the recommended dose against histamine- and platelet-activating factor-induced flare responses and ex vivo platelet aggregation in healthy males.
Topics: Administration, Oral; Adult; Area Under Curve; Cyproheptadine; Histamine; Histamine H1 Antagonists; Humans; Injections, Intradermal; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pruritus; Skin; Young Adult | 2010 |
Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor.
Topics: Anti-Allergic Agents; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cyproheptadine; Histamine; Humans; Interleukin-8; Mast Cells; Platelet Activating Factor; Substance P; Tumor Necrosis Factor-alpha | 2013 |
Rupatadine effectively prevents the histamine-induced up regulation of histamine H1R and bradykinin B2R receptor gene expression in the rat paw.
Topics: Animals; Cyproheptadine; Edema; Gene Expression Regulation; Histamine; Histamine H1 Antagonists; Rats; Real-Time Polymerase Chain Reaction; Receptor, Bradykinin B1; Receptor, Bradykinin B2; Receptors, Histamine H1; Up-Regulation | 2014 |
Potential association of mast cells with coronavirus disease 2019.
Topics: Cell Communication; Cholecalciferol; COVID-19; COVID-19 Drug Treatment; Cromolyn Sodium; Cyproheptadine; Cytokines; Famotidine; Histamine; Histamine Antagonists; Humans; Lung; Luteolin; Macrophages; Mast Cells; SARS-CoV-2; Severity of Illness Index; Substance P | 2021 |
Rupatadine protects the intestinal mucosa from injury by 5-flurouracil via modulation of inflammation, apoptosis and intestinal permeability.
Topics: Animals; Apoptosis; Aspartic Acid Proteases; Carboxymethylcellulose Sodium; Caspase 3; Cysteine; Fluorouracil; Glutathione; Histamine; Inflammation; Interleukin-10; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Irritants; Male; Malondialdehyde; NF-kappa B; Nitric Oxide; Permeability; Peroxidase; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2022 |
Rupatadine ameliorated ulcerative colitis in rats via modulation of platelet-activatiweng factor/interleukin-6/vascular endothelial growth factor signalling pathway.
Topics: Acetic Acid; Animals; Antioxidants; Colitis, Ulcerative; Colon; Cyproheptadine; Histamine; Interleukin-6; Male; Platelet Activating Factor; Rats; Rats, Wistar; Signal Transduction; Vascular Endothelial Growth Factor A | 2022 |