rumbrin and 2-pyrrolecarboxylic-acid

rumbrin has been researched along with 2-pyrrolecarboxylic-acid* in 1 studies

Other Studies

1 other study(ies) available for rumbrin and 2-pyrrolecarboxylic-acid

ArticleYear
Production of anticancer polyenes through precursor-directed biosynthesis.
    Organic & biomolecular chemistry, 2011, Sep-21, Volume: 9, Issue:18

    The biosynthesis of the pyrrolyl moiety of the fungal metabolite rumbrin originates from pyrrole-2-carboxylic acid. In an effort to produce novel derivatives with enhanced biological activity a series of substituted pyrrole-2-carboxylates were synthesised and incubated with the producing organism, Auxarthron umbrinum. Several 4-halo-pyrrole-2-carboxylic acids were incorporated into the metabolite yielding three new derivatives: 3-fluoro-, 3-chloro- and 3-bromo-isorumbrin, which were generated in milligram quantities enabling cytotoxicity assays to be conducted. The 3-chloro- and 3-bromo-isorumbrins had improved activity against HeLa cells compared with rumbrin; 3-bromoisorumbrin also showed dramatically improved activity towards a lung cancer cell line (A549).

    Topics: Antineoplastic Agents; Fungi; HeLa Cells; Humans; Inhibitory Concentration 50; Neoplasms; Polyenes; Proline; Pyrones; Pyrroles

2011