rufinamide has been researched along with triazoles in 145 studies
| Studies (rufinamide) | Trials (rufinamide) | Recent Studies (post-2010) (rufinamide) | Studies (triazoles) | Trials (triazoles) | Recent Studies (post-2010) (triazoles) |
|---|---|---|---|---|---|
| 175 | 22 | 118 | 25,808 | 2,252 | 13,501 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (2.76) | 18.2507 |
| 2000's | 23 (15.86) | 29.6817 |
| 2010's | 95 (65.52) | 24.3611 |
| 2020's | 23 (15.86) | 2.80 |
| Authors | Studies |
|---|---|
| Alif, L; Godbillon, J; Lecaillon, JB; Moes, D; Rouan, MC; Souppart, C | 1 |
| Chan, K; Cheung, WK; Cook, T; John, V; Kianifard, F; Mathieu, J; Redalieu, E; Wong, A | 1 |
| Bialer, M; Johannessen, SI; Kupferberg, HJ; Levy, RH; Loiseau, P; Perucca, E | 1 |
| Cardot, JM; Czendlik, C; Godbillon, J; Lecaillon, JB | 1 |
| Jain, KK | 1 |
| Canger, R; Henriksen, O; Karolchyk, MA; Pålhagen, S; Rivière, ME; van Parys, JA | 1 |
| Buffet, C; Humbert, H; Marfil, F; Masson, L; Maurer, G; Rouan, MC | 1 |
| Aldenkamp, AP | 1 |
| Aldenkamp, AP; Alpherts, WC | 1 |
| Deeks, ED; Scott, LJ | 1 |
| Anderson, GD; Cheng-Hakimian, A; Miller, JW | 1 |
| Arroyo, S | 1 |
| Miura, Y | 1 |
| Bouropoulos, N; Douroumis, D; Fahr, A | 1 |
| Anderson, GD; Cheng-Hakimian, A; Hakimian, S; Miller, JW | 1 |
| Heaney, D; Walker, MC | 1 |
| Kreutzkamp, B | 1 |
| Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH | 1 |
| Arroyo, S; Glauser, T; Kluger, G; Krauss, G; Perdomo, C; Sachdeo, R | 1 |
| Cloyd, J; Critchley, D; Fuseau, E; Perucca, E | 1 |
| Bast, T; Boor, R; Ernst, JP; Haberlandt, E; Kluger, G; Kurlemann, G; Makowski, C; Runge, U; Schneider, F | 2 |
| Stafstrom, CE | 1 |
| Arroyo, S; Brodie, MJ; Mann, A; Perdomo, C; Rosenfeld, WE; Sachdeo, R; Vazquez, B | 1 |
| Shah, RR | 1 |
| Verdian, L; Yi, Y | 1 |
| Conry, J; Krauss, G; LoPresti, A; Mann, A; Narurkar, M; Wheless, JW | 1 |
| Albani, F; Baruzzi, A; Candela, C; Contin, M; Mohamed, S; Riva, R | 1 |
| Elger, CE; Mann, A; Narurkar, M; Perdomo, C; Stefan, H; Sun, Y | 1 |
| Hussar, DA | 1 |
| Critchley, DJ; Fuseau, E; Marchand, M | 1 |
| Best, R; Hutchinson, DJ; Liou, Y; Zhao, F | 1 |
| Benedict, A; Maclaine, G; Verdian, L | 1 |
| Arroyo, S; Glauser, T; Kluger, G; Krauss, G; Perdomo, C; Seeruthun, R | 1 |
| Wisniewski, CS | 1 |
| Fava, M | 1 |
| Drake, K; Labiner, DM | 1 |
| Ferrie, CD | 1 |
| Balestri, A; Coppola, G; Curatolo, P; D'Aniello, A; Fels, A; Franzoni, E; Grosso, S; Habetswallner, F; Mangano, S; Parisi, P; Pascotto, A; Spalice, A; Veggiotti, P; Verrotti, A; Zamponi, N | 1 |
| Bergin, AM; Bourgeois, BF; Duffy, FH; Eksioglu, YZ; Gooty, VD; Kothare, SV; Libenson, M; Loddenkemper, T; Poduri, A; Rotenberg, A; Takeoka, M; Vendrame, M | 1 |
| Falchi, M; Filippi, L; Guerrini, R; Innocenti, M; la Marca, G; Malvagia, S; Moneti, G; Pellacani, S; Rosati, A | 1 |
| Bibbiani, F; Biton, V; Krauss, G; Mann, A; Narurkar, M; Perdomo, C; Vasquez-Santana, B | 1 |
| Balestri, A; Capovilla, G; Coppola, G; Curatolo, P; Fels, A; Franzoni, E; Grosso, S; Habetswallner, F; Mangano, S; Parisi, P; Pascotto, A; Spalice, A; Veggiotti, P; Verrotti, A; Zamponi, N | 1 |
| Joseph, JR; Schultz, RJ; Wilfong, AA | 1 |
| Kaufman, KR; Struck, PJ | 1 |
| Bergin, AM; Bourgeois, BF; Coulter, D; Duffy, FH; Kothare, SV; Libenson, MH; Loddenkemper, T; Olson, HE; Poduri, A; Rotenberg, A; Takeoka, M; Vendrame, M | 1 |
| Perucca, E; Prunetti, P | 1 |
| Besag, FM | 1 |
| Cerna, A; So, TY; Wier, HA | 1 |
| Boor, R; Brandt, C; Jürgens, U; Korn-Merker, E; May, TW; Rambeck, B | 1 |
| Coppola, G; Kluger, G; Kothare, SV; Loddenkemper, T; Poduri, A; Vendrame, M | 1 |
| Aluri, J; Bibbiani, F; Boyd, P; Critchley, DJ; Delargy, H; Narurkar, M; Whayman, M | 1 |
| Ballone, E; Chiarelli, F; Curatolo, P; Loiacono, G; Mattei, PA; Verrotti, A | 1 |
| Kluger, G; Leichsenring, M; Müller, A; Staudt, M; von Stülpnagel, C | 1 |
| Häusler, M; Kluger, G; Nikanorova, M | 1 |
| Boor, R; Coppola, G; Dahlin, M; Kluger, G; Lotte, J; Mueller, A; Staudt, M; Striano, P; von Stuelpnagel, C | 1 |
| Fattore, C; Franco, V; Gatti, G; Mazzucchelli, I; Perucca, E; Rapetti, M | 1 |
| Arzimanoglou, A; Brown, LW; Flamini, R; Harrison, M; Kerr, M; Kluger, G; Kothare, S; Narurkar, M; Philip, S; Resnick, T | 1 |
| Carlson, JE; Critchley, DJ; Lai, WG; Narurkar, M; Williams, ET; Wong, YN; Yoshimura, T | 1 |
| Chen, AV; Davies, NM; Martinez, SE; Wright, HM | 1 |
| Antzelevitch, C; Borggrefe, M; Brandt, C; Ebner, A; Göksu, T; Kuschyk, J; Papavassiliu, T; Rudic, B; Schimpf, R; Veltmann, C; Wolpert, C | 1 |
| Coppola, G; Kluger, G; Müller, A; Staudt, M; Striano, P; von Stülpnagel, C | 1 |
| McCormack, PL | 1 |
| Byeon, JH; Eun, BL; Eun, SH; Kang, HC; Kim, HD; Kim, SH; Kwon, EJ; Lee, JS; Lee, YM | 1 |
| Capuano, A; Curatolo, P; Cusmai, R; Fusco, L; Moavero, R; Specchio, N; Vigevano, F | 1 |
| Crespel, A; Gelisse, P; Mourand, I | 1 |
| Dahlin, MG; Ohman, I | 1 |
| Darshan, DV; Nagaveni, V; Prabhakar, S; Sravani, M; Vairamani, M | 1 |
| Anna Rita, M; Coppola, G; Curatolo, P; Isone, C; Kluger, G; Mueller, A; Parisi, P; Santoro, E; Verrotti, A; Zamponi, N | 1 |
| Ko, TS; Lee, EH; Yum, MS | 1 |
| Abriel, H; Decosterd, I; Kirschmann, G; Laedermann, CJ; Suter, MR | 1 |
| Chae, JH; Choi, JE; Hwang, YS; Kim, KJ; Kim, SH; Lee, JH; Lim, BC; Ryu, HW | 1 |
| Della Bona, ML; Falchi, M; Guerrini, R; la Marca, G; Malvagia, S; Pellacani, S; Rosati, A | 1 |
| Burrall, B; Konia, T; Shahbaz, S; Sivamani, RK | 1 |
| Borukhova, S; de Vos, E; Hessel, V; Metten, B; Noël, T | 1 |
| Dogaru, MT; Gáll, Z; Szilágyi, T; Vancea, S | 1 |
| Baum, L; Chan, PS; Kwan, P; Zhang, C; Zuo, Z | 1 |
| Battaglia, D; Coppola, G; Curatolo, P; Cusmai, R; D'Aniello, A; Di Gennaro, G; Matricardi, S; Moavero, R; Parisi, P; Pruna, D; Spalice, A; Verrotti, A; Vigevano, F | 1 |
| Bosmans, F; Diaz-Bustamante, M; Dutton, S; Escayg, A; Gilchrist, J; Kalia, J; McPherson, A; Olivares, N | 1 |
| Ito, S; Oguni, H | 1 |
| Ohtsuka, Y | 1 |
| Accorsi, P; Balestri, P; Coppola, G; Dontin, SD; Gobbi, G; Grosso, S; Parisi, P; Pruna, D; Verrotti, A | 1 |
| Besag, F; Coppola, G; Curatolo, P; Cusmai, R; Dulac, O; Kluger, G; Moavero, R; Nabbout, R; Nikanorova, M; Pisani, F; Verrotti, A; von Stülpnagel, C | 1 |
| Coppola, G; Delli Pizzi, A; Loiacono, G; Rossi, A; Tartaro, A; Verrotti, A | 1 |
| Bergin, AM; Bolton, J; Bourgeois, BF; Harini, C; Kadish, NE; Kapur, K; Kothare, SV; Libenson, M; Loddenkemper, T; Olson, H; Peters, J; Poduri, A; Ramgopal, S; Rotenberg, A; Sánchez Fernández, I; Takeoka, M; Thome-Souza, S | 1 |
| Alsaad, AM; Koren, G | 1 |
| Iyoda, K; Ohtsuka, Y; Shirasaka, Y; Takano, H; Takayama, R; Yoshinaga, H | 2 |
| Albini, M; Casciato, S; Di Bonaventura, C; Fanella, M; Fattouch, J; Giallonardo, AT; Lapenta, L; Manfredi, M; Morano, A | 1 |
| Gáll, O; Gáll, Z; Kolcsár, M; Szilágyi, T; Vancea, S | 1 |
| Awaya, T; Heike, T; Ide, M; Kato, T; Nakata, M; Saito, K; Yoshida, T | 1 |
| Cnaan, A; Dlugos, DJ; Kessler, SK; McCarthy, A | 1 |
| Kharatmal, SB; Sharma, SS; Singh, JN | 1 |
| Chen, H; He, X; Li, H; Li, W; Ni, Y; Xu, M; Zhou, Y | 1 |
| Arzimanoglou, A; Bibbiani, F; Critchley, D; Dhadda, S; Ferreira, JA; Hussein, Z; Kumar, D; Mendes, S; Satlin, A; Schuck, E; Williams, B | 1 |
| Chen, Z; Xu, Z; Zhao, H | 1 |
| Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B | 1 |
| Becerra, JL; Burcet, J; Cano, A; Falip, M; Fernández, S; Fossas, P; Jaraba, S; Miravet, E; Miró, J; Molins, A; Pico, G; Raspall, M; Santamarina, E; Toledo, M | 1 |
| Cock, HR; Thompson, AGB | 1 |
| de Paoli, FV; Nielsen, OB; Pedersen, TH; Skov, M | 1 |
| Bibbiani, F; Kluger, G; Kothare, S; Olhaye, O; Perdomo, C; Sachdeo, R; Williams, B | 1 |
| Bebin, EM; Cutter, GR; Gaston, TE; Liu, Y; Szaflarski, JP | 1 |
| Ahn, JH; Cho, JH; Kim, IH; Kim, SK; Lee, JC; Lee, TK; Lee, YJ; Ohk, TG; Park, CW; Park, JH; Seo, JY; Shin, BN; Shin, MC; Won, MH | 1 |
| Auvin, S; Brandt, C; McMurray, R; Nikanorova, M | 1 |
| Chavan, RB; Lodagekar, A; Mittapalli, S; Nangia, A; Salunke, N; Shastri, NR; Thipparaboina, R | 1 |
| Falip, M; McMurray, R; Santamarina, E; Striano, P | 1 |
| Adamo, A; Beingessner, RL; Briggs, N; Cui, Y; Dai, C; Jamison, TF; Jensen, KF; Kelly, LP; Lin, H; Myerson, AS; O'Mahony, M; Russell, MG; Stelzer, T; Tahara, K; Thomas, DA; Weeranoppanant, N; Zhang, P | 1 |
| Ahn, JH; Chen, BH; Hwang, IK; Kang, IJ; Kim, DW; Kim, H; Kim, YM; Lee, CH; Lee, JC; Lee, TK; Park, JH; Song, M; Won, MH; Yan, BC | 1 |
| Marson, AG; Panebianco, M; Prabhakar, H | 2 |
| Lee, CH; Park, JA | 1 |
| Minagawa, K; Takayama, R; Watanabe, T | 1 |
| Takahashi, Y; Takayama, R; Tsukamoto, K | 1 |
| Kang, HC; Kim, HD; Kim, SH; Lee, JS | 1 |
| Arzimanoglou, A; Bibbiani, F; Dhadda, S; Ferreira, J; Kumar, D; Olhaye, O; Satlin, A | 1 |
| Bommireddy, EP; Dalvi, AV; Ravi, PR; Uppuluri, CT | 1 |
| Chanda, K; M M, B; Maiti, B | 1 |
| Andreou, A; Angelone, D; Aragon-Camarasa, G; Cronin, L; Glatzel, S; Granda, JM; Hinkley, T; Keenan, G; Kitson, PJ; Steiner, S; Wolf, J | 1 |
| Aydınlı, N; Bektaş, G; Çalışkan, M; Hızlı, Z; Özmen, M; Tatlı, B; Ulak-Özkan, M; Yıldız, EP | 1 |
| Ahn, GN; Gyak, KW; Kang, JH; Kim, DP; Lee, HJ; You, D; Yu, T | 1 |
| Bozarth, XL; Oesch, G | 1 |
| Chatterjee, S; Gilmore, K; Guidi, M; Seeberger, PH | 1 |
| Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M | 1 |
| Auvin, S | 1 |
| Beccaria, F; Capovilla, G; De Giorgis, V; Fattore, C; Franco, V; Galimberti, CA; Gatti, G; Johannessen Landmark, C; Marchiselli, R; Mazzucchelli, I; Perucca, E; Rota, P | 1 |
| Aboumatar, S; Burdette, D; Chung, S; Kothare, S; Kuzniecky, R; Montouris, G; Rosenfeld, W | 1 |
| Città, S; Ciuffini, R; Coppola, G; Elia, M; Manfredi, V; Marrelli, A; Operto, FF; Pastorino, GMG; Sole, M; Striano, P; Verrotti, A; Zucca, C | 1 |
| Loddenkemper, T; Tanritanir, A; Wang, X | 1 |
| Hashem, HMA; Hassib, ST; Mahrouse, MA; Mostafa, EA | 2 |
| Chou, P; Hsueh, SW; Huang, CS; Kuo, CC; Lai, YC; Lin, TH; Lin, YC; Wang, RW; Yang, YC | 1 |
| Brigo, F; Eltze, C; Jones, K; Matricardi, S | 1 |
| Dawman, L; Panda, P; Panda, PK; Sharawat, IK | 1 |
| García-Peñas, JJ; Gil Nagel-Rein, A; Sánchez-Carpintero, R; Villanueva-Haba, V | 1 |
| Wang, C; Wang, J; Zhang, L | 1 |
| Kuo, CC; Lai, YC; Lin, TH; Lin, YC; Yang, YC | 1 |
| Imai, K; Inoue, Y; Kagawa, Y; Takahashi, Y; Usui, N; Yamamoto, Y | 1 |
| Alves, G; Falcão, A; Fortuna, A; Meirinho, S; Rodrigues, M | 1 |
| Arslan, EA; Cansu, A; Dilber, B; Esenülkü, G; Gürgen, SG; Kamaşak, T; Kart, PÖ; Şahin, S; Sarsmaz, HY; Topsakal, AS; Yazar, U; Yıldız, N | 1 |
| Huang, CW; Lai, MC; Wu, SN | 1 |
| Bhattacherjee, D; Chupakhin, ON; Das, P; Kopchuk, DS; Kovalev, IS; Purohit, R; Rahman, M; Rusinov, VL; Santra, S; Zyryanov, GV | 1 |
| Chez, M; Dixon-Salazar, T; Flamini, JR; Hyslop, A; McGoldrick, P; Millichap, JJ; Pina-Garza, JE; Resnick, T; Rho, JM; Sankar, R; Wolf, S | 1 |
37 review(s) available for rufinamide and triazoles
| Article | Year |
|---|---|
An assessment of rufinamide as an anti-epileptic in comparison with other drugs in clinical development.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Humans; Triazoles | 2000 |
Rufinamide: CGP 33101, E 2080, RUF 331, Xilep.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Drugs, Investigational; Epilepsy; Humans; Triazoles | 2005 |
Rufinamide.
Topics: Animals; Anticonvulsants; Clinical Trials as Topic; Humans; Seizures; Triazoles | 2006 |
Rufinamide: Pharmacology, clinical trials, and role in clinical practice.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Humans; Triazoles | 2006 |
Rufinamide.
Topics: Animals; Anticonvulsants; Brain; Clinical Trials as Topic; Epilepsy; Humans; Triazoles | 2007 |
[A new aspect in the research on antiepileptic drugs].
Topics: Acetamides; Amines; Animals; Anticonvulsants; Benzodiazepines; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Drug Design; Gabapentin; gamma-Aminobutyric Acid; Humans; Lacosamide; Levetiracetam; Phenylenediamines; Piracetam; Pregabalin; Pregnanolone; Pyrrolidinones; Triazoles | 2007 |
Rufinamide: a new anti-epileptic medication.
Topics: Adult; Animals; Anticonvulsants; Child; Drug Interactions; Epilepsy; Humans; Randomized Controlled Trials as Topic; Syndrome; Triazoles | 2007 |
Rufinamide.
Topics: Animals; Anticonvulsants; Drug Interactions; Epilepsy; Humans; Triazoles | 2007 |
[Rufinamide. An orphan drug for treatment of Lennox-Gastaut syndrome].
Topics: Anticonvulsants; Child, Preschool; Drug Interactions; Epilepsy; Female; Humans; Male; Syndrome; Triazoles | 2007 |
Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives.
Topics: Animals; Anticonvulsants; Drug Approval; Drug Design; Drug-Related Side Effects and Adverse Reactions; Humans; KATP Channels; Legislation, Drug; Long QT Syndrome; Triazoles | 2010 |
Safety and tolerability of rufinamide in children with epilepsy: a pooled analysis of 7 clinical studies.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Disorders of Excessive Somnolence; Double-Blind Method; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Female; Headache; Humans; Male; Treatment Outcome; Triazoles; Vomiting | 2009 |
Rufinamide: a new antiepileptic medication for the treatment of seizures associated with lennox-gastaut syndrome.
Topics: Aged; Anticonvulsants; Chemistry, Pharmaceutical; Child; Clinical Trials, Phase III as Topic; Counseling; Drug Resistance; Epilepsies, Partial; Epilepsy; Humans; Off-Label Use; Randomized Controlled Trials as Topic; Seizures; Syndrome; Triazoles | 2010 |
Rufinamide: a new antiepileptic drug treatment for Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy, Generalized; Humans; Syndrome; Triazoles | 2010 |
Rufinamide for refractory epilepsy in a pediatric and young adult population.
Topics: Adolescent; Age Factors; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Longitudinal Studies; Male; Treatment Outcome; Triazoles; Young Adult | 2011 |
New and forthcoming anti-epileptic drugs.
Topics: Acetamides; Anticonvulsants; Clinical Trials as Topic; Dioxolanes; Drug Approval; Drug Discovery; Epilepsy; Humans; Lacosamide; Remission Induction; Triazoles | 2011 |
Rufinamide for the treatment of Lennox-Gastaut syndrome.
Topics: Biological Availability; Double-Blind Method; Electroencephalography; Half-Life; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Placebos; Quality of Life; Randomized Controlled Trials as Topic; Spasms, Infantile; Triazoles | 2011 |
Rufinamide for pediatric patients with Lennox-Gastaut syndrome: a comprehensive overview.
Topics: Animals; Child; Epilepsies, Partial; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Spasms, Infantile; Treatment Outcome; Triazoles | 2011 |
Efficacy of rufinamide in drug-resistant epilepsy: a meta-analysis.
Topics: Anticonvulsants; Chi-Square Distribution; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsy; Humans; Odds Ratio; Triazoles | 2011 |
Rufinamide from clinical trials to clinical practice in the United States and Europe.
Topics: Anticonvulsants; Child; Child, Preschool; Europe; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Seizures; Spasms, Infantile; Treatment Outcome; Triazoles; United States | 2011 |
Rufinamide: a pharmacoeconomic profile of its use as adjunctive therapy in Lennox-Gastaut syndrome.
Topics: Administration, Oral; Anticonvulsants; Cost-Benefit Analysis; Economics, Pharmaceutical; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Models, Economic; Quality-Adjusted Life Years; Spasms, Infantile; Triazoles; United Kingdom | 2012 |
[Treatment of pediatric epilepsy].
Topics: Adolescent; Amines; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Dioxolanes; Drug Approval; Drug Substitution; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Infant; Lamotrigine; Levetiracetam; Patient Education as Topic; Piracetam; Practice Guidelines as Topic; Topiramate; Triazines; Triazoles; Valproic Acid | 2014 |
[New antiepileptic drugs: characteristics and clinical applications].
Topics: Amines; Anticonvulsants; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dioxolanes; Drug Approval; Drug Interactions; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Japan; Lamotrigine; Levetiracetam; Piracetam; Safety; Topiramate; Triazines; Triazoles | 2014 |
Current role of rufinamide in the treatment of childhood epilepsy: literature review and treatment guidelines.
Topics: Anticonvulsants; Epilepsy; Female; Guidelines as Topic; Humans; Male; Triazoles | 2014 |
Exposure to rufinamide and risks of CNS adverse events in drug-resistant epilepsy: a meta-analysis of randomized, placebo-controlled trials.
Topics: Anticonvulsants; Central Nervous System Diseases; Disorders of Excessive Somnolence; Dizziness; Drug Resistance; Epilepsy; Fatigue; Headache; Humans; Randomized Controlled Trials as Topic; Risk; Triazoles | 2014 |
Effectiveness of Rufinamide in the Treatment of Idiopathic Generalized Epilepsy With Atypical Evolution: Case Report and Review of the Literature.
Topics: Adult; Anticonvulsants; Disease Progression; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Humans; Treatment Outcome; Triazoles | 2016 |
The efficacy and safety of rufinamide in drug-resistant epilepsy: A meta-analysis of double-blind, randomized, placebo controlled trials.
Topics: Antipsychotic Agents; Double-Blind Method; Drug Resistant Epilepsy; Humans; Randomized Controlled Trials as Topic; Triazoles | 2016 |
Dosing considerations for rufinamide in patients with Lennox-Gastaut syndrome: Phase III trial results and real-world clinical data.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Treatment Outcome; Triazoles; Young Adult | 2017 |
Rufinamide for the treatment of Lennox-Gastaut syndrome: evidence from clinical trials and clinical practice.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Humans; Infant; Lennox Gastaut Syndrome; Outcome Assessment, Health Care; Triazoles; Young Adult | 2018 |
Rufinamide add-on therapy for refractory epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Drug Resistant Epilepsy; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Triazoles | 2018 |
Lennox-Gastaut syndrome: New treatments and treatments under investigation.
Topics: Anticonvulsants; Cannabidiol; Drug Development; Drugs, Investigational; Fenfluramine; Humans; Lennox Gastaut Syndrome; Nitriles; Pyridones; Therapies, Investigational; Triazoles | 2020 |
Expert opinion: Proposed diagnostic and treatment algorithms for Lennox-Gastaut syndrome in adult patients.
Topics: Algorithms; Anticonvulsants; Clinical Trials as Topic; Clobazam; Electroencephalography; Expert Testimony; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Sleep; Triazoles | 2020 |
Rufinamide add-on therapy for drug-resistant epilepsy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Bias; Child; Child, Preschool; Drug Resistant Epilepsy; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Randomized Controlled Trials as Topic; Triazoles | 2020 |
Anti-seizure medications for Lennox-Gastaut syndrome.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Cinnamates; Clobazam; Electroencephalography; Felbamate; Humans; Lamotrigine; Lennox Gastaut Syndrome; Middle Aged; Placebos; Randomized Controlled Trials as Topic; Topiramate; Triazoles; Wakefulness; Young Adult | 2021 |
Efficacy and safety of rufinamide as adjunctive therapy in patients with Lennox Gastaut syndrome: A systematic review and Meta-analysis.
Topics: Anticonvulsants; Humans; Lennox Gastaut Syndrome; Randomized Controlled Trials as Topic; Seizures; Triazoles | 2021 |
Cannabidiol for the treatment of Lennox-Gastaut syndrome and Dravet syndrome: experts' recommendations for its use in clinical practice in Spain.
Topics: Anticonvulsants; Cannabidiol; Clobazam; Clonazepam; Diazepam; Dioxolanes; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Lennox Gastaut Syndrome; Phenobarbital; Practice Guidelines as Topic; Pyrrolidinones; Spain; Triazoles; Valproic Acid | 2021 |
Efficacy and safety of antiseizure medication for Lennox-Gastaut syndrome: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Cannabidiol; Child; Humans; Lennox Gastaut Syndrome; Outcome Assessment, Health Care; Randomized Controlled Trials as Topic; Triazoles | 2022 |
Proposed anti-seizure medication combinations with rufinamide in the treatment of Lennox-Gastaut syndrome: Narrative review and expert opinion.
Topics: Anticonvulsants; Child, Preschool; Clobazam; Expert Testimony; Humans; Lennox Gastaut Syndrome; Triazoles | 2023 |
22 trial(s) available for rufinamide and triazoles
| Article | Year |
|---|---|
Intra- and inter-subject variabilities of CGP 33101 after replicate single oral doses of two 200-mg tablets and 400-mg suspension.
Topics: Administration, Oral; Adult; Analysis of Variance; Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Male; Middle Aged; Time Factors; Triazoles | 1995 |
The influence of food on the disposition of the antiepileptic rufinamide in healthy volunteers.
Topics: Administration, Oral; Adult; Analysis of Variance; Anticonvulsants; Area Under Curve; Cross-Over Studies; Female; Food-Drug Interactions; Half-Life; Humans; Intestinal Absorption; Male; Middle Aged; Triazoles | 1998 |
Rufinamide: a double-blind, placebo-controlled proof of principle trial in patients with epilepsy.
Topics: Adult; Anticonvulsants; Double-Blind Method; Drug Therapy, Combination; Epilepsy; Female; Half-Life; Humans; Incidence; Male; Middle Aged; Nervous System Diseases; Seizures; Triazoles | 2001 |
The effect of the new antiepileptic drug rufinamide on cognitive functions.
Topics: Adolescent; Adult; Anticonvulsants; Cognition; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Placebos; Triazoles | 2006 |
Rufinamide for generalized seizures associated with Lennox-Gastaut syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Female; Humans; Male; Syndrome; Treatment Outcome; Triazoles | 2008 |
Rufinamide for the adjunctive treatment of partial seizures in adults and adolescents: a randomized placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsies, Partial; Female; Humans; International Cooperation; Male; Middle Aged; Outcome Assessment, Health Care; Time Factors; Triazoles; Young Adult | 2009 |
A 24-week multicenter, randomized, double-blind, parallel-group, dose-ranging study of rufinamide in adults and adolescents with inadequately controlled partial seizures.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anticonvulsants; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Epilepsies, Partial; Humans; Intention to Treat Analysis; Middle Aged; Patient Selection; Severity of Illness Index; Treatment Outcome; Triazoles | 2010 |
Adjunctive rufinamide in Lennox-Gastaut syndrome: a long-term, open-label extension study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Epilepsy; Female; Humans; Longitudinal Studies; Male; Treatment Outcome; Triazoles; Young Adult | 2010 |
Rufinamide in refractory childhood epileptic encephalopathies other than Lennox-Gastaut syndrome.
Topics: Adolescent; Adult; Anticonvulsants; Brain Diseases; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Triazoles; Young Adult | 2011 |
A randomized, double-blind, placebo-controlled, parallel-group study of rufinamide as adjunctive therapy for refractory partial-onset seizures.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance; Epilepsies, Partial; Humans; Middle Aged; Sample Size; Seizures; Triazoles; Young Adult | 2011 |
Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Intellectual Disability; Italy; Lennox Gastaut Syndrome; Male; Spasms, Infantile; Treatment Outcome; Triazoles; Valproic Acid; Young Adult | 2010 |
Bioavailability of three rufinamide oral suspensions compared with the marketed 400-mg tablet formulation: results from a randomized-sequence, open-label, four-period, four-sequence crossover study in healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Anticonvulsants; Area Under Curve; Biological Availability; Cross-Over Studies; Europe; Female; Humans; Least-Squares Analysis; Male; Middle Aged; Suspensions; Tablets; Therapeutic Equivalency; Triazoles; United States; United States Food and Drug Administration; Young Adult | 2011 |
Efficacy of rufinamide in drug-resistant epilepsy: a meta-analysis.
Topics: Anticonvulsants; Chi-Square Distribution; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsy; Humans; Odds Ratio; Triazoles | 2011 |
Pharmacokinetics of oral rufinamide in dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Area Under Curve; Dogs; Female; Half-Life; Male; Pilot Projects; Triazoles | 2012 |
Rufinamide as an adjuvant treatment in children with Lennox-Gastaut syndrome.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Intellectual Disability; Lennox Gastaut Syndrome; Male; Spasms, Infantile; Triazoles | 2012 |
Rufinamide efficacy and safety as adjunctive treatment in children with focal drug resistant epilepsy: the first Italian prospective study.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Drug Therapy, Combination; Epilepsies, Partial; Female; Follow-Up Studies; Humans; Intellectual Disability; Italy; Lennox Gastaut Syndrome; Male; Prospective Studies; Spasms, Infantile; Treatment Outcome; Triazoles; Young Adult | 2012 |
A pharmacokinetic study and correlation with clinical response of rufinamide in infants with epileptic encephalopathies.
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Intellectual Disability; Lennox Gastaut Syndrome; Male; Spasms, Infantile; Triazoles | 2013 |
Rufinamide as an adjunctive therapy for Lennox-Gastaut syndrome: a randomized double-blind placebo-controlled trial in Japan.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Electroencephalography; Female; Follow-Up Studies; Humans; Japan; Lennox Gastaut Syndrome; Male; Statistics, Nonparametric; Treatment Outcome; Triazoles; Young Adult | 2014 |
Safety and pharmacokinetic profile of rufinamide in pediatric patients aged less than 4 years with Lennox-Gastaut syndrome: An interim analysis from a multicenter, randomized, active-controlled, open-label study.
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Infant; Lennox Gastaut Syndrome; Male; Triazoles | 2016 |
Long-term safety and seizure outcome in Japanese patients with Lennox-Gastaut syndrome receiving adjunctive rufinamide therapy: An open-label study following a randomized clinical trial.
Topics: Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Electrocardiography; Female; Humans; Japan; Lennox Gastaut Syndrome; Longitudinal Studies; Male; Time Factors; Treatment Outcome; Triazoles | 2016 |
Real-world data on rufinamide treatment in patients with Lennox-Gastaut syndrome: Results from a European noninterventional registry study.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Ethnicity; Europe; European Union; Female; Humans; Lennox Gastaut Syndrome; Male; Registries; Seizures; Sleep Stages; Treatment Outcome; Triazoles | 2017 |
Evaluation of long-term safety, tolerability, and behavioral outcomes with adjunctive rufinamide in pediatric patients (≥1 to <4 years old) with Lennox-Gastaut syndrome: Final results from randomized study 303.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Lennox Gastaut Syndrome; Male; Triazoles | 2019 |
87 other study(ies) available for rufinamide and triazoles
| Article | Year |
|---|---|
Automated analysis of a novel anti-epileptic compound, CGP 33,101, and its metabolite, CGP 47,292, in body fluids by high-performance liquid chromatography and liquid-solid extraction.
Topics: Anticonvulsants; Autoanalysis; Chromatography, High Pressure Liquid; Epilepsy; Humans; Hydrogen-Ion Concentration; Microchemistry; Quality Control; Sensitivity and Specificity; Solubility; Triazoles | 1995 |
Progress report on new antiepileptic drugs: a summary of the Third Eilat Conference.
Topics: Acetamides; Animals; Anticonvulsants; Azetidines; Carbamates; Drug Evaluation, Preclinical; Drugs, Investigational; Epilepsy; Humans; Israel; Levetiracetam; Nipecotic Acids; Phenylenediamines; Piracetam; Product Surveillance, Postmarketing; Randomized Controlled Trials as Topic; Thiazoles; Tiagabine; Triazoles | 1996 |
Practice of solid-phase extraction and protein precipitation in the 96-well format combined with high-performance liquid chromatography-ultraviolet detection for the analysis of drugs in plasma and brain.
Topics: Animals; Anticonvulsants; Benzoates; Brain Chemistry; Chemical Precipitation; Chromatography, High Pressure Liquid; Deferasirox; Molecular Structure; Pharmaceutical Preparations; Polystyrenes; Rats; Resins, Synthetic; Triazoles | 2001 |
Effects of antiepileptic drugs on cognition.
Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cognition; Cognition Disorders; Cyclohexanecarboxylic Acids; Epilepsy; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Lamotrigine; Levetiracetam; Nipecotic Acids; Oxcarbazepine; Piracetam; Tiagabine; Topiramate; Triazines; Triazoles; Vigabatrin | 2001 |
Physicochemical characterization of solid dispersions of three antiepileptic drugs prepared by solvent evaporation method.
Topics: Anticonvulsants; Calorimetry, Differential Scanning; Carbamazepine; Chemistry, Pharmaceutical; Crystallization; Drug Carriers; Hydrogen Bonding; Hypromellose Derivatives; Methylcellulose; Microscopy, Electron, Scanning; Oxcarbazepine; Solubility; Solvents; Spectroscopy, Fourier Transform Infrared; Triazoles; Wettability; X-Ray Diffraction | 2007 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; Mice; Phenobarbital; Phenytoin; Rats; Rats, Sprague-Dawley; Seizures; Severity of Illness Index; Triazoles; Valproic Acid | 2008 |
Rufinamide: clinical pharmacokinetics and concentration-response relationships in patients with epilepsy.
Topics: Administration, Oral; Adolescent; Age Factors; Anticonvulsants; Body Mass Index; Child; Child, Preschool; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Food; Half-Life; Humans; Intrinsic Factor; Kidney Diseases; Liver Diseases; Male; Metabolic Clearance Rate; Renal Dialysis; Sex Factors; Syndrome; Triazoles | 2008 |
Effectiveness and tolerability of rufinamide in children and adults with refractory epilepsy: first European experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Resistance; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Europe; Female; Humans; Infant; Male; Middle Aged; Orphan Drug Production; Retrospective Studies; Seizures; Treatment Outcome; Triazoles; Young Adult | 2009 |
American Epilepsy Society--62nd Annual Meeting. 5-9 December 2008, Seattle, USA.
Topics: Animals; Anticonvulsants; Biomarkers; Clinical Trials as Topic; Epilepsy; Humans; Infant; Ketones; Societies, Scientific; Spasms, Infantile; Triazoles; United States | 2009 |
Rufinamide (Banzel) for epilepsy.
Topics: Anticonvulsants; Clinical Trials as Topic; Drug Interactions; Epilepsy; Humans; Treatment Outcome; Triazoles | 2009 |
Product: Banzel.
Topics: Anticonvulsants; Child; Humans; Triazoles | 2009 |
Cost-utility analysis of rufinamide versus topiramate and lamotrigine for the treatment of children with Lennox-Gastaut Syndrome in the United Kingdom.
Topics: Anticonvulsants; Child; Confidence Intervals; Cost-Benefit Analysis; Drug Utilization; Epilepsy; Follow-Up Studies; Fructose; Health Status; Humans; Lamotrigine; Markov Chains; Quality of Life; Sensitivity and Specificity; Topiramate; Triazines; Triazoles; United Kingdom | 2010 |
Simultaneous HPLC-UV analysis of rufinamide, zonisamide, lamotrigine, oxcarbazepine monohydroxy derivative and felbamate in deproteinized plasma of patients with epilepsy.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Epilepsy; Felbamate; Humans; Isoxazoles; Lamotrigine; Oxcarbazepine; Phenylcarbamates; Propylene Glycols; Triazines; Triazoles; Ultraviolet Rays; Zonisamide | 2010 |
New Drugs2010, PART 1.
Topics: Acetamides; Antibodies, Monoclonal; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Azepines; Benzazepines; Benzhydryl Compounds; Benzyl Alcohol; Benzylamines; Cyclams; Cyclopropanes; Drug Combinations; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Ethanolamines; Everolimus; Febuxostat; Fluorenes; Fluoroquinolones; Gout Suppressants; Heterocyclic Compounds; Humans; Immunosuppressive Agents; Indoles; Lacosamide; Milnacipran; Oligopeptides; Phenols; Selective Serotonin Reuptake Inhibitors; Sirolimus; Tapentadol; Thiazoles; Tolvaptan; Triazoles | 2010 |
Supporting the recommended paediatric dosing regimen for rufinamide in Lennox-Gastaut syndrome using clinical trial simulation.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Clinical Trials as Topic; Computer Simulation; Drug Dosage Calculations; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Models, Statistical; Nonlinear Dynamics; Seizures; Syndrome; Triazoles | 2010 |
Stability of extemporaneously prepared rufinamide oral suspensions.
Topics: Adult; Anticonvulsants; Child; Chromatography, High Pressure Liquid; Drug Compounding; Drug Packaging; Drug Stability; Drug Storage; Epilepsy; Humans; Pharmaceutical Vehicles; Polypropylenes; Suspensions; Time Factors; Triazoles | 2010 |
The cost effectiveness of rufinamide in the treatment of Lennox-Gastaut syndrome in the UK.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Computer Simulation; Cost-Benefit Analysis; Epilepsy, Absence; Fructose; Health Care Costs; Humans; Infant; Intellectual Disability; Lamotrigine; Models, Economic; Randomized Controlled Trials as Topic; Syndrome; Time Factors; Topiramate; Treatment Outcome; Triazines; Triazoles; United Kingdom | 2010 |
First European long-term experience with the orphan drug rufinamide in childhood-onset refractory epilepsy.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Child; Child, Preschool; Epilepsy; Europe; Female; Humans; Infant; Longitudinal Studies; Male; Middle Aged; Orphan Drug Production; Product Surveillance, Postmarketing; Retrospective Studies; Severity of Illness Index; Treatment Outcome; Triazoles; Young Adult | 2010 |
The possible antianxiety and mood-stabilizing effects of rufinamide.
Topics: Adult; Affect; Alcohol Drinking; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Bulimia; Drug Therapy, Combination; Female; Humans; Off-Label Use; Triazoles | 2010 |
Severe constipation associated with the use of rufinamide (Banzel) in an adolescent.
Topics: Adolescent; Anticonvulsants; Constipation; Epilepsies, Partial; Female; Humans; Triazoles | 2010 |
Experience with rufinamide in a pediatric population: a single center's experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Pediatrics; Retrospective Studies; Seizures; Treatment Outcome; Triazoles; Young Adult | 2010 |
Rapid assay of rufinamide in dried blood spots by a new liquid chromatography-tandem mass spectrometric method.
Topics: Anticonvulsants; Blood Specimen Collection; Chemistry Techniques, Analytical; Chemistry, Pharmaceutical; Child, Preschool; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Male; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Tandem Mass Spectrometry; Triazoles | 2011 |
Activation of suicidal ideation with adjunctive rufinamide in bipolar disorder.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Electroconvulsive Therapy; Female; Humans; Suicide, Attempted; Triazoles | 2011 |
Rufinamide for the treatment of epileptic spasms.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Male; Retrospective Studies; Spasms, Infantile; Treatment Outcome; Triazoles; Young Adult | 2011 |
Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Male; Middle Aged; Seizures; Spasms, Infantile; Triazoles; Valproic Acid; Young Adult | 2011 |
Treatment of malignant migrating partial epilepsy of infancy with rufinamide: report of five cases.
Topics: Anticonvulsants; Brain; Child, Preschool; Electroencephalography; Epilepsies, Partial; Female; Humans; Male; Treatment Outcome; Triazoles | 2011 |
Refractory focal epilepsy in a patient with methylmalonic aciduria: case report on positive and long-lasting effect of rufinamide.
Topics: Anticonvulsants; Child, Preschool; Epilepsies, Partial; Humans; Hyperammonemia; Magnetic Resonance Imaging; Male; Methylmalonic Acid; Triazoles | 2011 |
Epilepsy with myoclonic absences - favourable response to add-on rufinamide treatment in 3 cases.
Topics: Anticonvulsants; Child, Preschool; Epilepsies, Myoclonic; Humans; Male; Retrospective Studies; Triazoles | 2011 |
Low long-term efficacy and tolerability of add-on rufinamide in patients with Dravet syndrome.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Longitudinal Studies; Male; Myoclonic Epilepsy, Juvenile; NAV1.1 Voltage-Gated Sodium Channel; Nerve Tissue Proteins; Retrospective Studies; Seizures, Febrile; Sodium Channels; Treatment Outcome; Triazoles; Young Adult | 2011 |
Development and validation of an HPLC-UV detection assay for the determination of rufinamide in human plasma and saliva.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Drug Stability; Humans; Molecular Structure; Reproducibility of Results; Saliva; Spectrophotometry, Ultraviolet; Time Factors; Triazoles | 2011 |
Investigation of the metabolism of rufinamide and its interaction with valproate.
Topics: Acyl Coenzyme A; Anticonvulsants; Biotransformation; Butyrates; Carboxylesterase; Cytosol; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Hydrolysis; Intestines; Liver; Microsomes, Liver; Triazoles; Valproic Acid | 2011 |
Drug-induced QT-interval shortening following antiepileptic treatment with oral rufinamide.
Topics: Administration, Oral; Adult; Aged; Anticonvulsants; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Electrocardiography; Epilepsy; Female; Follow-Up Studies; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Male; Middle Aged; Spasms, Infantile; Triazoles; Young Adult | 2012 |
First long-term experience with the orphan drug rufinamide in children with myoclonic-astatic epilepsy (Doose syndrome).
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Female; Humans; Male; Retrospective Studies; Surveys and Questionnaires; Treatment Outcome; Triazoles; Young Adult | 2012 |
Dramatic weight loss with rufinamide.
Topics: Adolescent; Adult; Anticonvulsants; Body Mass Index; Epilepsy; Female; Humans; Male; Triazoles; Weight Loss; Young Adult | 2013 |
Rufinamide in children with refractory epilepsy: pharmacokinetics, efficacy, and safety.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Infant; Male; Retrospective Studies; Triazoles; Valproic Acid | 2012 |
Study on the noncovalent interactions of antiepileptic drugs and amyloid β 1-40 peptide by electrospray ionization mass spectrometry.
Topics: Acetamides; Amino Acid Sequence; Amyloid beta-Peptides; Anticonvulsants; Humans; Lacosamide; Molecular Sequence Data; Peptide Fragments; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Triazoles | 2012 |
Rufinamide for refractory focal seizures: an open-label, multicenter European study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Europe; Female; Humans; Longitudinal Studies; Male; Middle Aged; Seizures; Treatment Outcome; Triazoles; Young Adult | 2013 |
Effectiveness and tolerability of rufinamide in children and young adults with Lennox-Gastaut syndrome: a single center study in Korea.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Female; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Male; Neurosurgical Procedures; Republic of Korea; Retrospective Studies; Seizures; Spasms, Infantile; Treatment Outcome; Triazoles; Young Adult | 2013 |
Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Hyperalgesia; Mice; Mice, Inbred C57BL; Neuralgia; Physical Stimulation; Triazoles; Voltage-Gated Sodium Channels | 2013 |
Short-term efficacy and tolerability of rufinamide adjunctive therapy in children with refractory generalised epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsy, Generalized; Female; Humans; Intellectual Disability; Lennox Gastaut Syndrome; Male; Spasms, Infantile; Treatment Outcome; Triazoles | 2013 |
A case of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) related to rufinamide.
Topics: Anti-Inflammatory Agents; Anticonvulsants; Child; Drug Hypersensitivity Syndrome; Epilepsy, Complex Partial; Fructose; Humans; Levetiracetam; Male; Piracetam; Prednisone; Topiramate; Triazoles | 2013 |
Solvent- and catalyst-free huisgen cycloaddition to rufinamide in flow with a greener, less expensive dipolarophile.
Topics: Catalysis; Cycloaddition Reaction; Solvents; Triazoles | 2013 |
Liquid chromatography-mass spectrometric determination of rufinamide in low volume plasma samples.
Topics: Acetamides; Animals; Chromatography, High Pressure Liquid; Humans; Lacosamide; Limit of Detection; Rabbits; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Triazoles | 2013 |
In vitro transport assays of rufinamide, pregabalin, and zonisamide by human P-glycoprotein.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Transformed; Dogs; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gene Expression; Humans; Isoxazoles; Pregabalin; Rhodamine 123; Swine; Transfection; Triazoles; Zonisamide | 2014 |
Rufinamide for the treatment of refractory epilepsy secondary to neuronal migration disorders.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Germany; Humans; Italy; Male; Malformations of Cortical Development, Group II; Prospective Studies; Treatment Outcome; Triazoles; Young Adult | 2014 |
Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents.
Topics: Action Potentials; Animals; Anticonvulsants; Cells, Cultured; Drug Discovery; Epilepsy; Hippocampus; Humans; Male; Mice; NAV1.1 Voltage-Gated Sodium Channel; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Triazoles; Xenopus | 2014 |
Efficacy and safety of rufinamide in children under four years of age with drug-resistant epilepsies.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Male; Retrospective Studies; Treatment Outcome; Triazoles | 2014 |
Successful Treatment of Refractory Seizures With Rufinamide in Children With Schizencephaly: Report of 3 Cases.
Topics: Anticonvulsants; Child; Electroencephalography; Humans; Magnetic Resonance Imaging; Male; Schizencephaly; Seizures; Triazoles | 2015 |
Safety and retention rate of rufinamide in 300 patients: a single pediatric epilepsy center experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Cohort Studies; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Infant; Male; Patient Compliance; Prospective Studies; Retrospective Studies; Sleep Wake Disorders; Treatment Outcome; Triazoles; Vomiting; Young Adult | 2014 |
Dose-dependent pharmacokinetics and brain penetration of rufinamide following intravenous and oral administration to rats.
Topics: Administration, Intravenous; Administration, Oral; Animals; Brain; Dogs; Humans; Male; Rats, Wistar; Triazoles | 2015 |
A granulocytosis associated with rufinamide: A case report.
Topics: Agranulocytosis; Anticonvulsants; Child; Clonazepam; Epilepsy; Humans; Male; Triazoles; Valproic Acid | 2015 |
Retention rates of rufinamide in pediatric epilepsy patients with and without Lennox-Gastaut Syndrome.
Topics: Adolescent; Anticonvulsants; Child; Cohort Studies; Epilepsy; Female; Humans; Kaplan-Meier Estimate; Lennox Gastaut Syndrome; Male; Treatment Outcome; Triazoles | 2015 |
Rufinamide Improves Functional and Behavioral Deficits via Blockade of Tetrodotoxin-Resistant Sodium Channels in Diabetic Neuropathy.
Topics: Animals; Biophysical Phenomena; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Ganglia, Spinal; Mental Disorders; Neural Conduction; Neurons; Patch-Clamp Techniques; Rats; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Triazoles | 2015 |
Pharmacokinetics and Tolerability of Rufinamide Following Single and Multiple Oral Doses and Effect of Food on Pharmacokinetics in Healthy Chinese Subjects.
Topics: Administration, Oral; Area Under Curve; Asian People; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Food; Food-Drug Interactions; Half-Life; Healthy Volunteers; Humans; Male; Tablets; Triazoles | 2016 |
Aggravation of atonic seizures by rufinamide: A case report.
Topics: Anticonvulsants; Benzodiazepines; Brain; Child; Clobazam; Drug Resistant Epilepsy; Drug Therapy, Combination; Electroencephalography; Humans; Levetiracetam; Male; Piracetam; Seizures; Triazoles; Valproic Acid | 2016 |
Rufinamide in children and adults in routine clinical practice.
Topics: Adolescent; Adult; Anticonvulsants; Child; Epilepsy, Generalized; Female; Humans; Lennox Gastaut Syndrome; Male; Middle Aged; Seizures; Triazoles; Vomiting; Weight Loss | 2017 |
Successful treatment of super-refractory tonic status epilepticus with rufinamide: First clinical report.
Topics: Adult; Anticonvulsants; Drug Resistant Epilepsy; Humans; Male; Status Epilepticus; Triazoles; Young Adult | 2016 |
The anti-convulsants lacosamide, lamotrigine, and rufinamide reduce myotonia in isolated human and rat skeletal muscle.
Topics: Acetamides; Animals; Anthracenes; Anticonvulsants; Area Under Curve; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Female; Humans; In Vitro Techniques; Isometric Contraction; Lacosamide; Lamotrigine; Male; Muscle, Skeletal; Myotonia; Rats; Rats, Wistar; Triazines; Triazoles | 2017 |
Interactions between cannabidiol and commonly used antiepileptic drugs.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Benzodiazepines; Cannabidiol; Child; Child, Preschool; Clobazam; Dose-Response Relationship, Drug; Drug Interactions; Epilepsy; Female; Fructose; Humans; Male; Middle Aged; Topiramate; Triazoles; Young Adult | 2017 |
Rufinamide pretreatment attenuates ischemia-reperfusion injury in the gerbil hippocampus.
Topics: Animals; Astrocytes; Avoidance Learning; CA1 Region, Hippocampal; Carotid Artery Diseases; Disease Models, Animal; Gerbillinae; Ischemic Attack, Transient; Male; Microglia; Motor Activity; Neuroprotective Agents; Pyramidal Cells; Reperfusion Injury; Time Factors; Triazoles | 2017 |
Rufinamide: Crystal structure elucidation and solid state characterization.
Topics: Anticonvulsants; Calorimetry, Differential Scanning; Chromatography, High Pressure Liquid; Crystallization; Crystallography, X-Ray; Dimethylformamide; Drug Compounding; Drug Liberation; Excipients; Solubility; Thermogravimetry; Triazoles | 2018 |
Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing.
Topics: Automation; Ciprofloxacin; Neostigmine; Nicardipine; Pharmaceutical Preparations; Triazoles | 2018 |
Rufinamide, an antiepileptic drug, improves cognition and increases neurogenesis in the aged gerbil hippocampal dentate gyrus via increasing expressions of IGF-1, IGF-1R and p-CREB.
Topics: Aging; Animals; Anticonvulsants; Body Weight; Brain-Derived Neurotrophic Factor; Cognition; CREB-Binding Protein; Dentate Gyrus; Gene Expression Regulation; Gerbillinae; Insulin-Like Growth Factor I; Ki-67 Antigen; Male; Microscopy, Fluorescence; Neurogenesis; Receptor, IGF Type 1; Receptor, trkB; Triazoles | 2018 |
Effect of Rufinamide on the kainic acid-induced excitotoxic neuronal death in the mouse hippocampus.
Topics: Animals; Cell Death; Dose-Response Relationship, Drug; Hippocampus; Kainic Acid; Male; Mice; Mice, Inbred ICR; Neurons; Structure-Activity Relationship; Triazoles | 2018 |
Short-term efficacy and safety of rufinamide for Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Child; Female; Humans; Lennox Gastaut Syndrome; Male; Pedigree; Triazoles | 2016 |
Three children with Lennox-Gastaut syndrome presenting long-term good seizure outcome under rufinamide treatment.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Lennox Gastaut Syndrome; Male; Seizures; Time Factors; Treatment Outcome; Triazoles | 2017 |
Rufinamide efficacy and safety in children aged 1-4 years with Lennox-Gastaut syndrome.
Topics: Adjuvants, Pharmaceutic; Anticonvulsants; Child, Preschool; Female; Humans; Infant; Lennox Gastaut Syndrome; Male; Outcome Assessment, Health Care; Retrospective Studies; Triazoles | 2018 |
Design of experiments-based RP - HPLC bioanalytical method development for estimation of Rufinamide in rat plasma and brain and its application in pharmacokinetic study.
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Stability; Linear Models; Male; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Triazoles | 2018 |
Evaluation of WO2014121383 A1: a process for preparation of rufinamide and intermediates.
Topics: Animals; Anticonvulsants; Child; Humans; Lennox Gastaut Syndrome; Patents as Topic; Triazoles | 2019 |
Organic synthesis in a modular robotic system driven by a chemical programming language.
Topics: Automation; Chemistry Techniques, Synthetic; Diphenhydramine; Programming Languages; Robotics; Sildenafil Citrate; Software; Technology, Pharmaceutical; Triazoles | 2019 |
Efficacy of rufinamide in childhood refractory epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Resistant Epilepsy; Female; Humans; Male; Reproducibility of Results; Retrospective Studies; Treatment Outcome; Triazoles | 2018 |
A numbering-up metal microreactor for the high-throughput production of a commercial drug by copper catalysis.
Topics: Alkynes; Azides; Catalysis; Copper; Cycloaddition Reaction; Microfluidics; Printing, Three-Dimensional; Stainless Steel; Triazoles | 2019 |
Rufinamide efficacy and association with phenotype and genotype in children with intractable epilepsy: A retrospective single center study.
Topics: Anticonvulsants; Child; Child, Preschool; Drug Resistant Epilepsy; Epilepsy; Female; Genotype; Humans; Infant; Lennox Gastaut Syndrome; Male; Phenotype; Retrospective Studies; Seizures; Triazoles | 2020 |
Automated radial synthesis of organic molecules.
Topics: Anticonvulsants; Automation; Carbon; Chemistry Techniques, Synthetic; Indicators and Reagents; Nitrogen; Oxidation-Reduction; Photochemical Processes; Small Molecule Libraries; Software; Solutions; Triazoles | 2020 |
Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients.
Topics: Adolescent; Anticonvulsants; Argentina; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy; Female; Follow-Up Studies; Humans; Lennox Gastaut Syndrome; Male; Retrospective Studies; Seizures; Triazoles; Valproic Acid | 2020 |
Relationship between saliva and plasma rufinamide concentrations in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Drug Monitoring; Epilepsy; Female; Humans; Male; Saliva; Triazoles; Young Adult | 2020 |
Cognitive, adaptive, and behavioral effects of adjunctive rufinamide in Lennox-Gastaut syndrome: A prospective observational clinical study.
Topics: Adolescent; Adult; Anticonvulsants; Child; Cognition; Humans; Lennox Gastaut Syndrome; Middle Aged; Prospective Studies; Triazoles; Young Adult | 2020 |
Efficacy and Tolerability of Rufinamide in Epileptic Children Younger Than 4 Years.
Topics: Age Factors; Anticonvulsants; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Retrospective Studies; Treatment Outcome; Triazoles | 2021 |
Determination of Rufinamide in the Presence of 1-[(2,6-Difluorophenyl)Methyl]-1H-1,2,3-Triazole-4 Carboxylic Acid Using RP-HPLC and Derivative Ratio Methods as Stability Indicating Assays to Be Applied on Dosage Form.
Topics: Carboxylic Acids; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Triazoles | 2020 |
Development and Bio-Analytical Validation of Chromatographic Determination Method of Rufinamide in Presence of its Metabolite in Human Plasma.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Drug Monitoring; Drug Stability; Humans; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Therapeutic Equivalency; Triazoles | 2021 |
How Can an Na
Topics: Animals; Female; Lennox Gastaut Syndrome; Male; Mice; Mice, Inbred C57BL; Neurons; Seizures; Triazoles; Voltage-Gated Sodium Channel Blockers | 2021 |
Selective stabilization of the intermediate inactivated Na
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Female; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Organ Culture Techniques; Protein Stability; Triazoles; Voltage-Gated Sodium Channel Blockers; Voltage-Gated Sodium Channels | 2022 |
Therapeutic Drug Monitoring for Rufinamide in Japanese Patients With Epilepsy: Focus on Drug Interactions, Tolerability, and Clinical Effectiveness.
Topics: Anticonvulsants; Drug Interactions; Drug Monitoring; Epilepsy; Humans; Japan; Retrospective Studies; Seizures; Treatment Outcome; Triazoles | 2022 |
Study of the metabolic stability profiles of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro human model.
Topics: Anticonvulsants; Carbamazepine; Cytochrome P-450 Enzyme Inducers; Dioxolanes; Drug Interactions; Humans; Nitriles; Phenobarbital; Pyridones; Rifampin; Triazoles | 2022 |
An investigation of the effects of chronic zonisamide, sultiam, lacosamide, clobazam, and rufinamide anti-seizure medications on foliculogenesis in ovarian tissue in prepubertal non-epileptic rats.
Topics: Animals; Clobazam; Female; Lacosamide; Rats; Rats, Wistar; Thiazines; Triazoles; Zonisamide | 2022 |
Rufinamide, a Triazole-Derived Antiepileptic Drug, Stimulates Ca
Topics: Anticonvulsants; Ions; Molecular Docking Simulation; Triazoles | 2022 |
Mechanochemical Approach towards Multi-Functionalized 1,2,3-Triazoles and Anti-Seizure Drug Rufinamide Analogs Using Copper Beads.
Topics: Alkynes; Azides; Catalysis; Copper; Triazoles | 2022 |