Compounds > ruboxistaurin
Page last updated: 2024-09-04

ruboxistaurin and verapamil

ruboxistaurin has been researched along with verapamil in 2 studies

Compound Research Comparison

Studies
(ruboxistaurin)		Trials
(ruboxistaurin)		Recent Studies (post-2010)
(ruboxistaurin)		Studies
(verapamil)		Trials
(verapamil)		Recent Studies (post-2010) (verapamil)
203295617,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomyruboxistaurin (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Amano, T; Hotta, N; Matsubara, T; Nakayama, S; Watanabe, J1
Hawkins, BT; Miller, DS; Rigor, RR1

Other Studies

2 other study(ies) available for ruboxistaurin and verapamil

ArticleYear
Insulin modulation of intracellular free magnesium in heart: involvement of protein kinase C.
    British journal of pharmacology, 2000, Volume: 130, Issue:4

    Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Heart; Hemodynamics; Hydrogen-Ion Concentration; In Vitro Techniques; Indoles; Insulin; Isoproterenol; Magnesium; Male; Maleimides; Myocardium; Phosphates; Phosphocreatine; Protein Kinase C; Rats; Rats, Wistar; Verapamil

2000
Activation of PKC isoform beta(I) at the blood-brain barrier rapidly decreases P-glycoprotein activity and enhances drug delivery to the brain.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2010, Volume: 30, Issue:7

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Capillaries; Enzyme Activation; Humans; Indoles; Isoenzymes; Maleimides; Pharmaceutical Preparations; Phorbol Esters; Protein Kinase C; Protein Kinase C beta; Rats; Signal Transduction; Sucrose; Tumor Necrosis Factor-alpha; Verapamil

2010