Compounds > ruboxistaurin
Page last updated: 2024-09-04

ruboxistaurin and sb 203580

ruboxistaurin has been researched along with sb 203580 in 6 studies

Compound Research Comparison

Studies
(ruboxistaurin)		Trials
(ruboxistaurin)		Recent Studies (post-2010)
(ruboxistaurin)		Studies
(sb 203580)		Trials
(sb 203580)		Recent Studies (post-2010) (sb 203580)
20329563,48941,137

Protein Interaction Comparison

ProteinTaxonomyruboxistaurin (IC50)sb 203580 (IC50)
Citron Rho-interacting kinaseHomo sapiens (human)1
Cyclin-G-associated kinaseHomo sapiens (human)0.4133
Mitogen-activated protein kinase 13Homo sapiens (human)0.2329
Mitogen-activated protein kinase 2Pneumocystis carinii0.105
Receptor-interacting serine/threonine-protein kinase 2Homo sapiens (human)1.0359
RAF proto-oncogene serine/threonine-protein kinaseHomo sapiens (human)0.7575
Cytochrome P450 1A2Homo sapiens (human)2
Tyrosine-protein kinase LckHomo sapiens (human)3.45
Neutrophil elastaseHomo sapiens (human)0.025
Cytochrome P450 3A4Homo sapiens (human)0.062
Cytochrome P450 2D6Homo sapiens (human)2
TyrosinaseMus musculus (house mouse)0.034
Cholesteryl ester transfer proteinHomo sapiens (human)0.04
Cytochrome P450 2C9 Homo sapiens (human)1
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)5
Serine/threonine-protein kinase B-rafHomo sapiens (human)1
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)0.36
Prostaglandin G/H synthase 1Homo sapiens (human)2
Thromboxane-A synthase Homo sapiens (human)0.494
Adenosine receptor A2aHomo sapiens (human)6.068
Ephrin type-B receptor 2Homo sapiens (human)7.8
Adenosine receptor A1Homo sapiens (human)2.95
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.01
Delta-type opioid receptorMus musculus (house mouse)0.02
Cytochrome P450 2C19Homo sapiens (human)0.8
TGF-beta receptor type-1Homo sapiens (human)6
Mitogen-activated protein kinase 9Homo sapiens (human)0.9517
Mitogen-activated protein kinase 14 Mus musculus (house mouse)0.056
Casein kinase I isoform deltaHomo sapiens (human)0.4147
Casein kinase I isoform epsilonHomo sapiens (human)1
Mitogen-activated protein kinase 12Homo sapiens (human)0.2329
Mitogen-activated protein kinase 10Homo sapiens (human)0.6933
Mitogen-activated protein kinase 1Rattus norvegicus (Norway rat)0.048
Myotonin-protein kinaseHomo sapiens (human)1
Mitogen-activated protein kinase 11Homo sapiens (human)0.2646
Mitogen-activated protein kinase 14Homo sapiens (human)0.39
P2X purinoceptor 7Homo sapiens (human)5
Serine/threonine-protein kinase 36Homo sapiens (human)1
Serine/threonine-protein kinase NLKHomo sapiens (human)1
TRAF2 and NCK-interacting protein kinaseHomo sapiens (human)1

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Atteridge, CE; Azimioara, MD; Benedetti, MG; Biggs, WH; Carter, TA; Ciceri, P; Edeen, PT; Fabian, MA; Floyd, M; Ford, JM; Galvin, M; Gerlach, JL; Grotzfeld, RM; Herrgard, S; Insko, DE; Insko, MA; Lai, AG; Lélias, JM; Lockhart, DJ; Mehta, SA; Milanov, ZV; Patel, HK; Treiber, DK; Velasco, AM; Wodicka, LM; Zarrinkar, PP1
Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N1
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Atteridge, CE; Campbell, BT; Chan, KW; Ciceri, P; Davis, MI; Edeen, PT; Faraoni, R; Floyd, M; Gallant, P; Herrgard, S; Hunt, JP; Karaman, MW; Lockhart, DJ; Milanov, ZV; Morrison, MJ; Pallares, G; Patel, HK; Pritchard, S; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Russu, WA; Shallal, HM1
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1

Other Studies

6 other study(ies) available for ruboxistaurin and sb 203580

ArticleYear
A small molecule-kinase interaction map for clinical kinase inhibitors.
    Nature biotechnology, 2005, Volume: 23, Issue:3

    Topics: Benzamides; Drug Design; Escherichia coli; Escherichia coli Proteins; Imatinib Mesylate; Microchemistry; Pharmaceutical Preparations; Piperazines; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Pyrimidines

2005
The selectivity of protein kinase inhibitors: a further update.
    The Biochemical journal, 2007, Dec-15, Volume: 408, Issue:3

    Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera

2007
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
A quantitative analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2008, Volume: 26, Issue:1

    Topics: Binding Sites; Enzyme Activation; Humans; Phosphotransferases; Protein Binding; Protein Interaction Mapping; Protein Kinase Inhibitors; Proteome; Quantitative Structure-Activity Relationship

2008
Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Stereoisomerism; Structure-Activity Relationship

2011
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011