ru-66647 and azetidine

ru-66647 has been researched along with azetidine* in 1 studies

Other Studies

1 other study(ies) available for ru-66647 and azetidine

Article	Year
Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections. Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23 Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious safety concerns, hepatotoxicity in particular. We have discovered a novel series of azetidinyl ketolides that focus on mitigation of hepatotoxicity by minimizing hepatic turnover and time-dependent inactivation of CYP3A isoforms in the liver without compromising the potency and efficacy of 1. Topics: Animals; Azetidines; Bacteria; Community-Acquired Infections; Disease Susceptibility; Drug Discovery; Drug Resistance, Multiple; Drug-Related Side Effects and Adverse Reactions; Humans; Ketolides; Mice; Microbial Sensitivity Tests; Respiratory Tract Infections	2009

Article

Year

Discovery of azetidinyl ketolides for the treatment of susceptible and multidrug resistant community-acquired respiratory tract infections.

Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

Respiratory tract bacterial strains are becoming increasingly resistant to currently marketed macrolide antibiotics. The current alternative telithromycin (1) from the newer ketolide class of macrolides addresses resistance but is hampered by serious safety concerns, hepatotoxicity in particular. We have discovered a novel series of azetidinyl ketolides that focus on mitigation of hepatotoxicity by minimizing hepatic turnover and time-dependent inactivation of CYP3A isoforms in the liver without compromising the potency and efficacy of 1.

Topics: Animals; Azetidines; Bacteria; Community-Acquired Infections; Disease Susceptibility; Drug Discovery; Drug Resistance, Multiple; Drug-Related Side Effects and Adverse Reactions; Humans; Ketolides; Mice; Microbial Sensitivity Tests; Respiratory Tract Infections

2009