rtki cpd has been researched along with u 0126 in 40 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 22 (55.00) | 29.6817 |
| 2010's | 16 (40.00) | 24.3611 |
| 2020's | 2 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J | 1 |
| Al-Mazaideh, GM; Erdmann, F; Göllner, C; Rohe, A; Schmidt, M; Sippl, W; Wichapong, K | 1 |
| Caballero, E; García-Cárceles, J; Gil, C; Martínez, A | 1 |
| Abe, K; Saito, H | 1 |
| Arteaga, CL; Coffey, RJ; Forbes, JT; Lenferink, AE; Shawver, LK; Simpson, JF | 1 |
| Bergström, JD; Heldin, NE; Westermark, B | 1 |
| Arteaga, CL; Forbes, JT; Kurokawa, H; Lenferink, AE; Pisacane, PI; Simpson, JF; Sliwkowski, MX | 1 |
| Cussac, D; Denis, C; Paris, H; Schaak, S | 1 |
| Gavard, J; Mège, RM; Monnet, C; Sobel, A | 1 |
| Chalothorn, D; Faber, JE; Jackson, LF; Lee, DC; Zhang, H | 1 |
| Kolachana, P; Lawsin, LM; Moore, J; Perlman, A; Ringel, MD; Saji, M | 1 |
| Bunting, M; Hanson, BJ; Hanson, GT; O'Grady, M; Raha, D | 1 |
| Abe, M; Egami, H; Hirota, M; Nozawa, F; Ogawa, M; Tan, X | 1 |
| Kim, SY; Kim, YK; Kwon, CH; Lee, JS | 1 |
| Kanda, Y; Watanabe, Y | 1 |
| Daubert, RA; Schnellmann, RG; Yan, Y; Zhuang, S | 1 |
| Ascoli, M; Shiraishi, K | 1 |
| Chao, HH; Chen, YL; Cheng, TH; Chiu, WT; Hong, HJ; Lin, JW; Liu, JC; Shyu, KG; Wu, CH | 1 |
| Furukawa, S; He, Y; Koketsu, M; Nishina, A; Sekiguchi, A | 1 |
| Chen, DY; Hou, Y; Li, M; Liang, CG; Lin, SL; Schatten, H; Sun, QY; Xiong, B; Xu, BZ | 1 |
| Cai, L; Du, T; Hertz, L; Li, B; Li, H; Peng, L; Song, D | 1 |
| Cai, L; Hertz, L; Li, B; Nu, W; Peng, L; Zhang, H; Zhang, S | 1 |
| Choi, WS; Han, JW; Jeong, KJ; Kang, JK; Kim, YK; Lee, HY; Lee, KB; Park, CG; Park, SY; Seo, JH | 1 |
| Buharalioglu, CK; Malik, KU; Mugabe, BE; Song, CY; Waters, CM; Yaghini, FA | 1 |
| Feng, R; Hu, Q; Li, L; Li, M; Wang, S; Wen, J; Yang, X; Zhang, L | 1 |
| Galettis, P; Links, M; Luk, PP | 1 |
| Biswas, A; Carbajal, L; Hammes, SR; Niswander, LM; Prizant, H | 1 |
| Furukawa, Y; Karakida, S; Kawano, Y; Narahara, H; Sasaki, T; Utsunomiya, Y | 1 |
| Grandal, MV; Grøvdal, LM; Holst, MR; Kim, J; Knudsen, SL; van Deurs, B | 1 |
| Arao, T; Maegawa, M; Matsumoto, K; Nishio, K | 1 |
| Ikari, A; Sato, T; Sugatani, J; Watanabe, R; Yamazaki, Y | 1 |
| Cebrián-Pérez, JA; Colás, C; Luna, C; Muiño-Blanco, T; Pérez-Pé, R | 1 |
| Bae, YK; Choi, MS; Hong, KM; Kim, HT; Kim, S; Kim, YN; Kwon, JY; Shim, J; Sung, JY | 1 |
| Kim, HS; Lee, SY; Shin, SJ | 1 |
| Bi, LL; Chen, M; Gan, XD; Wang, YG; Wang, ZQ; Zhao, F | 1 |
| Gao, FH; Guo, YH; Jiang, B; Shi, J; Yuan, HH | 1 |
| Andric, N; Fa, S; Kaisarevic, S; Kovacevic, R; Odzic, L; Pogrmic-Majkic, K; Samardzija, D | 1 |
| Chen, B; Chicoine, LG; Jin, Y; Liu, Y; Nelin, LD; White, HA | 1 |
| Azuma, M; Kim, M; Ko, S; Lee, DA; Lee, SH; Park, H; Parsons, MJ; Prober, D; Shin, D; So, J | 1 |
1 review(s) available for rtki cpd and u 0126
| Article | Year |
|---|---|
Kinase Inhibitors as Underexplored Antiviral Agents.
Topics: Animals; Antiviral Agents; Drug Repositioning; Humans; Protein Kinase Inhibitors; Virus Diseases; Viruses | 2022 |
39 other study(ies) available for rtki cpd and u 0126
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection | 2009 |
Evaluation of potential Myt1 kinase inhibitors by TR-FRET based binding assay.
Topics: Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Glycolipids; Humans; Membrane Proteins; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Structure-Activity Relationship | 2013 |
The mitogen-activated protein kinase cascade mediates neurotrophic effect of epidermal growth factor in cultured rat hippocampal neurons.
Topics: Animals; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hippocampus; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tyrphostins | 2000 |
Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice.
Topics: Animals; Butadienes; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Dimerization; DNA; Down-Regulation; ErbB Receptors; Female; Humans; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nitriles; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins | 2000 |
Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells.
Topics: Antineoplastic Agents; Butadienes; Carcinoma; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-met; Quinazolines; RNA, Messenger; Suramin; Thyroid Neoplasms; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 2000 |
Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.
Topics: Animals; Breast Neoplasms; Butadienes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Gene Expression; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Tamoxifen; Transcription, Genetic; Tyrphostins; Xenograft Model Antitumor Assays | 2000 |
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Arachidonic Acid; Bacterial Proteins; Brimonidine Tartrate; Butadienes; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; MAP Kinase Signaling System; Matrix Metalloproteinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; Pertussis Toxin; Phosphorylation; Protein Binding; Proteins; Quinacrine; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Swine; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella | 2002 |
Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Butadienes; Cells, Cultured; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Mice; Microscopy, Confocal; Microtubule Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Nitriles; Phosphoproteins; Phosphorylation; PrPC Proteins; Quinazolines; RNA, Small Interfering; Stathmin; Tyrphostins | 2004 |
Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anthracenes; Aorta, Thoracic; Bacterial Proteins; Benzopyrans; Butadienes; Catheterization; Cell Division; Dipeptides; ErbB Receptors; Flavonoids; Glycine; Hydroxamic Acids; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Organ Culture Techniques; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Thrombin; Tyrphostins | 2004 |
Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.
Topics: Angiotensin II; Animals; Butadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Immunoblotting; Losartan; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tyrphostins | 2004 |
Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer.
Topics: Antibodies, Monoclonal; beta-Lactamases; Butadienes; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunohistochemistry; Inhibitory Concentration 50; MAP Kinase Kinase 1; Neoplasms; Nitriles; Oligonucleotides, Antisense; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transfection; Tyrphostins | 2005 |
Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway.
Topics: Adenocarcinoma; Adult; Aged; Blotting, Western; Butadienes; Culture Media, Conditioned; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Male; Matrix Metalloproteinase 7; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Nitriles; Pancreatic Neoplasms; Quinazolines; Signal Transduction; Tight Junctions; Tumor Cells, Cultured; Tyrphostins | 2005 |
EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells.
Topics: Animals; Apoptosis; Butadienes; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hydrogen Peroxide; Kidney Tubules, Proximal; MAP Kinase Kinase 1; Membrane Potentials; Mitochondrial Membranes; Nitriles; Opossums; Oxidants; Pyrimidines; Quinazolines; Transfection; Tyrphostins | 2006 |
Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells.
Topics: Animals; Blotting, Western; Butadienes; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Hexamethonium; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitriles; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tyrphostins; Vascular Endothelial Growth Factor A | 2007 |
Epiregulin promotes proliferation and migration of renal proximal tubular cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rabbits; Tyrphostins; Wound Healing | 2007 |
Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.
Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Dipeptides; Epidermal Growth Factor; Flavonoids; Immunohistochemistry; Inositol Phosphates; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyrazoles; Pyrimidines; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Steroids; Tyrphostins | 2007 |
Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Blotting, Northern; Blotting, Western; Butadienes; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Endothelin-1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Leptin; Male; Metalloendopeptidases; Myocytes, Smooth Muscle; Nitriles; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Signal Transduction; Transcriptional Activation; Tyrosine; Tyrphostins | 2007 |
Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.
Topics: Animals; Antioxidants; Azoles; Butadienes; Carbazoles; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Indole Alkaloids; Isoindoles; Mitogen-Activated Protein Kinases; Neurites; Neurofilament Proteins; Nitriles; Organoselenium Compounds; Oxidation-Reduction; PC12 Cells; Pertussis Toxin; Phosphorylation; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Selenium; Tyrphostins | 2008 |
PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte.
Topics: Animals; Butadienes; Cells, Cultured; Chromones; Cumulus Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Meiosis; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Swine; Tyrphostins | 2008 |
Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent.
Topics: Animals; Astrocytes; Butadienes; Cell Size; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Mice; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Quinazolines; Stimulation, Chemical; Transcriptional Activation; Tyrphostins; Vasopressins; Water | 2008 |
Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.
Topics: Aminopyridines; Animals; Antidepressive Agents, Second-Generation; Astrocytes; Butadienes; Calcium; Cells, Cultured; Chelating Agents; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fluorobenzenes; Fluoxetine; Gene Expression; Indoles; Maleimides; Mice; Nitriles; Phosphorylation; Piperidines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Quinazolines; Receptor, Serotonin, 5-HT2B; RNA, Messenger; Signal Transduction; Substrate Specificity; Transcriptional Activation; Tyrphostins; Up-Regulation; Urea | 2008 |
Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.
Topics: Butadienes; Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Cyclooxygenase 2; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Nitriles; Ovarian Neoplasms; Pertussis Toxin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; Quinazolines; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins | 2008 |
Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Butadienes; Cell Culture Techniques; Cell Migration Assays; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; src-Family Kinases; Syk Kinase; Transcriptional Activation; Tyrphostins | 2010 |
The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; Chromones; Enzyme Inhibitors; ErbB Receptors; Immunohistochemistry; In Vitro Techniques; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neurons; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; RNA Interference; SOXB1 Transcription Factors; Tyrphostins | 2010 |
ERK phosphorylation predicts synergism between gemcitabine and the epidermal growth factor receptor inhibitor AG1478.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gemcitabine; Humans; Mutation; Nitriles; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; RNA, Small Interfering; Tyrphostins | 2011 |
GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovary.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Butadienes; Cyclic AMP-Dependent Protein Kinases; Doxycycline; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Gonadotropins, Equine; Humans; Luteinizing Hormone; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Nitriles; Ovarian Follicle; Ovary; Progesterone; Quinazolines; Receptor Cross-Talk; Receptors, Corticotropin; Receptors, LH; Signal Transduction; Tyrphostins | 2011 |
Effect of heparin-binding EGF-like growth factor and amphiregulin on the MAP kinase-induced production of vascular endothelial growth factor by human granulosa cells.
Topics: Amphiregulin; Blotting, Western; Butadienes; Cell Line; Cell Proliferation; EGF Family of Proteins; Enzyme-Linked Immunosorbent Assay; Female; Glycoproteins; Granulosa Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Nitriles; Quinazolines; Tyrphostins; Vascular Endothelial Growth Factors | 2011 |
EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Chromones; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Gene Expression; Gene Expression Profiling; Humans; Imidazoles; MAP Kinase Kinase 1; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation | 2012 |
What can and cannot be done using a microarray analysis? Treatment stratification and clinical applications in oncology.
Topics: Antineoplastic Agents; Butadienes; Early Growth Response Protein 1; ErbB Receptors; Gene Expression Profiling; Genes, Neoplasm; HEK293 Cells; Humans; Microarray Analysis; Molecular Targeted Therapy; Mutation; Neoplasms; Nitriles; Protein Kinase Inhibitors; Quinazolines; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Tyrphostins | 2011 |
Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Binding Sites; Butadienes; Cell Line, Tumor; Claudins; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protease Inhibitors; Protein Binding; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transcription Factor AP-1; Tyrphostins | 2012 |
A novel epidermal growth factor-dependent extracellular signal-regulated MAP kinase cascade involved in sperm functionality in sheep.
Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Quinazolines; Sheep; Sperm Capacitation; Spermatozoa; Tissue Distribution; Tyrphostins | 2012 |
An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs.
Topics: Animals; Antineoplastic Agents; Butadienes; Caenorhabditis elegans; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Humans; Models, Animal; Mutation; Neoplasms; Nitriles; Phenotype; Protein Structure, Tertiary; Quinazolines; Transgenes; Tyrphostins | 2012 |
ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53.
Topics: Antioxidants; Apoptosis; Benzothiazoles; Butadienes; Cell Line, Tumor; Cyclic N-Oxides; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Osteosarcoma; Phosphorylation; Piperazines; Protein Transport; Quinazolines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53; Tyrphostins | 2013 |
Time-dependent regulation of neuregulin-1β/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells.
Topics: Actins; Animals; Atrial Natriuretic Factor; Butadienes; Cell Differentiation; Cell Line; Embryoid Bodies; Embryonic Stem Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GATA4 Transcription Factor; Gene Expression Regulation, Developmental; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Mice; Myocytes, Cardiac; Myosin Light Chains; Neuregulin-1; Nitriles; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; T-Box Domain Proteins; Time Factors; Transcription Factors; Tyrphostins | 2013 |
[EGFR-ERK signaling pathway down-regulates miRNA-145 in lung cancer cells].
Topics: Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Quinazolines; Tyrphostins | 2013 |
Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal growth factor receptor in rat granulosa cells.
Topics: Animals; Butadienes; Cells, Cultured; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Granulosa Cells; Hydrocarbons, Brominated; MAP Kinase Signaling System; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar; Receptors, LH; Toxicity Tests; Tyrphostins | 2014 |
Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells.
Topics: Arginase; Butadienes; Cell Count; Cell Hypoxia; Cell Proliferation; Cell Survival; Culture Media, Conditioned; Endothelial Cells; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Gene Silencing; Humans; Lung; Microvessels; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; RNA, Small Interfering; Tyrphostins | 2017 |
Attenuating the Epidermal Growth Factor Receptor-Extracellular Signal-Regulated Kinase-Sex-Determining Region Y-Box 9 Axis Promotes Liver Progenitor Cell-Mediated Liver Regeneration in Zebrafish.
Topics: Animals; Animals, Genetically Modified; Butadienes; Cell Differentiation; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Liver Regeneration; MAP Kinase Signaling System; Nitriles; Quinazolines; SOX9 Transcription Factor; Stem Cells; Tyrphostins; Zebrafish | 2021 |