rtki cpd has been researched along with quinazolines in 722 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 42 (5.82) | 18.2507 |
| 2000's | 385 (53.32) | 29.6817 |
| 2010's | 281 (38.92) | 24.3611 |
| 2020's | 14 (1.94) | 2.80 |
| Authors | Studies |
|---|---|
| Caday, CG; Cavenee, WK; Han, Y; Huang, HJ; Nanda, A | 1 |
| Chelluderai, B; Dutta, S; Fligiel, SE; Jaszewski, R; Majumdar, AP; Tureaud, J | 1 |
| Böhmer, FD; Fernández, LE; Greiser, U; Lage, A; Perez, R; Sánchez, B; Suarez Pestana, E | 1 |
| Klein, JM; McCarthy, TA | 1 |
| Ben-Bassat, H; Gal, I; Klein, BY; Shlomai, Z; Tepper, SH | 1 |
| Levitzki, A; Osherov, N | 1 |
| Berthelemy, M; Dangles, V; Féménia, F; Lainé, V; Le Rhun, D; Levy, D; Poupon, MF; Schwartz-Cornil, I | 1 |
| Arteaga, CL; Guyer, CA; Ramsey, TT; Shawver, LK | 1 |
| Ben-Bassat, H; Gazit, A; Hartzstark, Z; Kleinberger-Doron, N; Levitzki, A; Levitzki, R; Plowman, G; Rosenbaum-Mitrani, S; Shlomai, Z; Tsvieli, R | 1 |
| Chen, PB; Contessa, JN; Dent, P; Kavanagh, BD; Mikkelsen, RB; Rorrer, WK; Schmidt-Ullrich, RK; Todd, DG; Valerie, K | 1 |
| Cantley, LG; Kjelsberg, CA; Nigam, SK; Sakurai, H; Tsukamoto, T | 1 |
| Breu, J; Muchnicki, L; Slack, BE; Wurtman, RJ | 1 |
| Higashimoto, Y; Kanayama, S; Kiyohara, T; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Tsutsui, S; Zushi, S | 1 |
| Iozzo, RV; Mann, DM; McQuillan, DJ; Moscatello, DK; Santra, M; Wong, AJ | 1 |
| Antonyak, MA; Moscatello, DK; Wong, AJ | 1 |
| Iozzo, RV; McQuillan, DJ; Patel, S; Santra, M; Thomas, AP | 1 |
| Eguchi, S; Hirata, Y; Inagami, T; Iwasaki, H; Kawakatsu, H; Marumo, F; Matsumoto, T; Motley, ED; Numaguchi, K; Owada, KM; Utsunomiya, H; Yamakawa, T | 1 |
| DeWild, LJ; Klein, JM; McCarthy, TA | 1 |
| Cavenee, WK; Gazit, A; Huang, HJ; Levitzki, A; Nagane, M | 1 |
| Eguchi, S; Hirata, Y; Iwasaki, H; Marumo, F | 1 |
| Hartkamp, J; Rapp, UR; Troppmair, J | 1 |
| Soltoff, SP | 1 |
| Ben-Bassat, H; Klein, BY; Rojansky, N; Stekelenburg, J | 1 |
| Dalmau, SR; Freitas, CS; Savino, W | 1 |
| Barrett, KE; Keely, SJ; Uribe, JM | 1 |
| Higashimoto, Y; Kanayama, S; Kiyohara, T; Kondo, S; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Zushi, S | 1 |
| Farrell, GC; Zhang, BH | 1 |
| Mei, L; Si, J | 1 |
| Daaka, Y; Della Rocca, GJ; Lefkowitz, RJ; Luttrell, LM; Maudsley, S | 1 |
| Gohla, A; Offermanns, S; Schultz, G; Wilkie, TM | 1 |
| Akhand, AA; Kato, M; Kurokawa, K; Liu, W; Miyata, T; Nakashima, I; Uchida, K; Yokoyama, I | 1 |
| Bonner, JC; Moomaw, CR; Morgan, DL; Rice, AB | 1 |
| Hochegger, K; Marian, B; Partik, G; Schörkhuber, M | 1 |
| Allal, C; Asslan, R; Favre, G; Le Gaillard, F; Pradines, A; Pratx, C | 1 |
| Brecher, P; Wang, D; Yu, X | 1 |
| Gillham, H; Golding, MC; Gullick, WJ; Pepperkok, R | 1 |
| Mikkelsen, RB; Rorrer, WK; Schmidt-Ullrich, RK; Todd, DG; Valerie, K | 1 |
| Ben-Bassat, H; Chaouat, M; Chen, H; Gazit, A; Harzstark, Z; Klein, BY; Levitzki, A; Levitzki, R; McCollough, J; McMahon, J; Narog, B; Powell, TJ; Shawver, L; Shenoy, N; Tang, C | 1 |
| Minneman, KP; Zhong, H | 1 |
| Farrelly, ER; Ho, JJ; Kim, YS | 1 |
| Polk, DB; Tong, W | 1 |
| Eguchi, K; Eguchi, S; Frank, GD; Hirata, Y; Inagami, T; Iwasaki, H; Marumo, F; Motley, ED; Ueno, H | 1 |
| Ogata, T | 1 |
| Eguchi, S; Hirata, Y; Iwasaki, H; Marumo, F; Ueno, H | 1 |
| Daaka, Y; Lefkowitz, RJ; Luttrell, LM; Maudsley, S; Pierce, KL | 1 |
| Braun, L; Chase, CC; Frew, T; Hurley, DJ; Rowland, RR; Shaw, AM | 1 |
| Cupp, AS; Levine, E; Miyashiro, L; Skinner, MK | 1 |
| Guo, C; Luttrell, LM; Price, DT | 1 |
| Arteaga, CL; Busse, D; Doughty, RS; Flanagan, WM; Price, JO; Ramsey, TT; Russell, WE; Shawver, LK | 1 |
| Abe, K; Saito, H | 1 |
| Jensen, RL; Petr, M; Wurster, RD | 1 |
| Dorko, K; Esplen, JE; Jo, M; Michalopoulos, GK; Stolz, DB; Strom, SC | 1 |
| Jope, RS; Song, L; Zhang, L | 1 |
| Carpenter, G; Ji, QS | 1 |
| Barrett, KE; Calandrella, SO; Keely, SJ | 1 |
| Bonner, JC; Wang, YZ | 1 |
| Dalbone, AC; Hutcheon, AE; Takahashi, H; Zieske, JD | 1 |
| DeMattia, JA; Khoshyomn, S; Naraghi, S; Vane, DW | 1 |
| Abraham, JA; Clowes, AW; Daum, G; Kalmes, A; Vesti, BR | 1 |
| Bates, SE; Bishop, PC; Blagosklonny, MV; Fojo, T; Robey, R | 1 |
| Arteaga, CL; Coffey, RJ; Forbes, JT; Lenferink, AE; Shawver, LK; Simpson, JF | 1 |
| Bergström, JD; Heldin, NE; Westermark, B | 1 |
| del Carmen Medina, L; García-Sáinz, JA; Vázquez-Prado, J | 1 |
| Jue, SF; Maurer, RA; Wang, YH | 1 |
| Bagnato, A; Catt, KJ; Tecce, R; Vacca, F | 1 |
| Brattain, MG; Jackson, JG; Koterba, AP; Kreisberg, JI; Yee, D | 1 |
| Arteaga, CL; Forbes, JT; Kurokawa, H; Lenferink, AE; Pisacane, PI; Simpson, JF; Sliwkowski, MX | 1 |
| Delouvée, A; el-Marjou, A; Radvanyi, F; Thiery, JP | 1 |
| Fujiyama, S; Higashiyama, S; Iba, O; Iwasaka, T; Jyo, N; Koyama, Y; Maruyama, K; Masaki, H; Matsubara, H; Mori, Y; Nose, A; Nozawa, Y; Ogata, N; Tateishi, E; Tsutsumi, Y; Uchiyama, Y | 1 |
| Eichstetter, I; Häkkinen, L; Kähäri, VM; Larjava, H; Lozzo, RV; Scott, PG; Strassburger, S | 1 |
| Conway, A; Pyne, NJ; Pyne, S | 1 |
| Billestrup, N; Brender, C; Kaltoft, K; Mikkelsen, G; Nielsen, M; Odum, N; Wasik, M; Zhang, Q | 1 |
| Eguchi, S; Frank, GD; Inagami, T; Motley, ED | 1 |
| Cavenee, WK; Huang, HJ; Lin, H; Nagane, M | 1 |
| Egeblad, M; Jäättelä, M; Mortensen, OH; van Kempen, LC | 1 |
| Belt, A; Fisher, G; Voorhees, J; Wan, Y; Wang, Z | 1 |
| Chun, JS; Kim, JH; Song, WK | 1 |
| Carmines, PK; Che, Q; Fallet, RW; Fujiwara, K | 1 |
| Berven, LA; Crouch, MF; Davy, DA; Willard, FS | 1 |
| Berk, BC; Chen, K; Keaney, JF; Vita, JA | 1 |
| Adrian, TE; Cluck, MW; Knezetic, JA; Larsson, J; Lovas, S; Murphy, LO; Murphy, RF; Otvös, F; Permert, J; Schally, AV | 1 |
| Kanda, Y; Kuroki, Y; Mizuno, K; Watanabe, Y | 1 |
| Burchiel, SW; Burdick, AD; Davis, JW; Hudson, LG; Lauer, FT | 1 |
| Amir, C; Bowers, G; Dent, P; Hewitt, T; Lammering, G; Mikkelsen, RB; Reardon, D; Schmidt-Ullrich, RK; Valerie, K | 1 |
| Burgess, AW; Ellis, AG; Levitzki, A; Nice, EC; Webster, LK; Weinstock, J | 1 |
| Haslett, C; Jodrell, D; MacKinnon, AC; Sethi, T; Waters, C | 1 |
| Lavictoire, SJ; Lorimer, IA | 1 |
| Chavis, P; Westbrook, G | 1 |
| Huggett, TM; Jost, M; Kari, C; Rodeck, U | 1 |
| Feng, GK; Li, ZM; Liu, ZC; Xie, BF; Yang, D; Zeng, YX; Zhu, XF | 1 |
| Sagi-Eisenberg, R; Shefler, I | 1 |
| Devlin, RB; Ghio, AJ; Samet, JM; Wu, W | 1 |
| Nishinaka, T; Yabe-Nishimura, C | 1 |
| Kodama, S; Suzuki, K; Watanabe, M | 1 |
| Adachi, H; Fujioka, T; Kim, JH; Saito, K; Tsujimoto, M; Ui, M; Yokoyama, S | 1 |
| Rozengurt, E; Santiskulvong, C; Sinnett-Smith, J | 2 |
| Arteaga, CL; Busse, D; Flanagan, WM; Lenferink, AE; Yakes, FM | 1 |
| Burgess, AW; Cavenee, WK; Huang, HJ; Levitzki, A; Mishima, K; Nagane, M; Narita, Y | 1 |
| Bourdoulous, S; Couraud, PO; Eugène, E; Hoffmann, I; Nassif, X | 1 |
| Pouysségur, J; Viñals, F | 1 |
| Bode, AM; Chen, N; Dong, Z; Liu, G; Ma, WY; She, QB; Wu, E | 1 |
| Keates, AC; Keates, S; Kelly, CP; Peek, RM; Shaw, LM; Sougioultzis, S; Zhao, D | 1 |
| Brattain, MG; Ghosh, P; Humphrey, LE; Kreisberg, JI; Sawhney, RS; Zhou, GH | 1 |
| Fukuda, K; Kato, T; Kodama, H; Miyoshi, S; Ogawa, S; Tahara, S | 1 |
| Atabai, K; Birch, M; Burgel, PR; Lazarus, SC; Nadel, JA; Tam, DC; Ueki, IF | 1 |
| Adler, KB; Bonner, JC; Booth, BW; Martin, LD; Tournier, F | 1 |
| Chang, MS; Conn, PJ; Peavy, RD; Sanders-Bush, E | 1 |
| Chen, K; Keaney, JF; Thomas, SR | 1 |
| Cavenee, WK; Huang, HJ; Steinbach, JP; Supra, P; Weller, M | 1 |
| El-Obeid, A; Hesselager, G; Nistér, M; Westermark, B | 1 |
| Chakravarti, A; Dyson, NJ; Loeffler, JS | 1 |
| Bates, SE; Bishop, PC; Blagosklonny, MV; Fry, DW; Liu, ET; Myers, T; Robey, R | 1 |
| Avkiran, M; Hearse, DJ; Snabaitis, AK | 1 |
| Gildea, JJ; Gulding, KM; Harding, MA; Seraj, MJ; Theodorescu, D | 1 |
| Alberto Olivares-Reyes, J; Catt, KJ; Shah, BH; Yesilkaya, A | 1 |
| Baatar, D; Pai, R; Pavelka, M; Soreghan, B; Szabo, IL; Tarnawski, AS | 1 |
| Bode, AM; Chen, N; Dong, Z; Ma, WY; Zhang, Y | 1 |
| Carreras, I; DiCamillo, SJ; Foster, JA; Nugent, MA; Panchenko, MP; Panchenko, MV; Stone, PJ | 1 |
| Cussac, D; Denis, C; Paris, H; Schaak, S | 1 |
| Choi, BH; Choi, JS; Hahn, SJ; Jo, YH; Kim, MS; Min, DS; Rhie, DJ; Yoon, SH | 1 |
| Eckhart, AD; Eguchi, S; Kim, J; Koch, WJ | 1 |
| Liang, NC; Liu, XG | 1 |
| Enrich, C; Lladó, A; Tebar, F | 1 |
| Gamady, A; Koren, R; Liberman, UA; Ravid, A; Rotem, C; Rubinstein, E | 1 |
| Archer, GE; Friedman, HS; Glazer, CA; Lal, A; Martinson, HM; Riggins, GJ; Sampson, JH | 1 |
| Aguirre Ghiso, J; Estrada, Y; Liu, D; Ossowski, L | 1 |
| Montgomery, RB | 1 |
| Chen, MC; Kui, R; Perez Salazar, E; Rozengurt, E; Soll, AH; Solomon, TE | 1 |
| Barrett, KE; McCole, DF; Uribe, JM | 1 |
| Carter, RW; Kanagy, NL | 1 |
| Al-Ghoul, WM; Choudhry, MA; Fazal, N; Sayeed, MM; Schmidt, MJ | 1 |
| Cohen, MV; Downey, JM; Krieg, T; McIntosh, EC; Qin, Q | 1 |
| Cowen, DS; Johnson-Farley, NN; Quinn, JC; Yoon, J | 1 |
| Chen, X; Resh, MD | 1 |
| Carmines, PK; Che, Q | 1 |
| Chan, FL; Chang, C; Huang, J; Lee, YF; Lin, WJ; Messing, EM; Wilding, G | 1 |
| Gschwind, A; Prenzel, N; Ullrich, A | 1 |
| Koty, PP; Lei, W; Levitt, ML | 1 |
| Levin, ER; Park, ST; Pedram, A; Razandi, M | 1 |
| Huang, XL; Lawrence, M; Madara, P; Nanavaty, UB; Pawliczak, R; Shelhamer, JH | 1 |
| Dobashi, K; Ishizuka, T; Kawata, T; Mori, M; Shimizu, Y; Tsukagoshi, H | 1 |
| Chen, X; Pennock, S; Wang, Y; Wang, Z | 1 |
| Chatziantoniou, C; Coffman, T; Dussaule, JC; Flamant, M; Henrion, D; Placier, S; Tharaux, PL | 1 |
| Alonso, A; Dürst, M; Leykauf, K | 1 |
| Collins, JF; Ghishan, FK; Hines, ER; Inouye, M; Xu, H | 1 |
| Hunger-Glaser, I; Rozengurt, E; Salazar, EP | 1 |
| Busse, R; Fisslthaler, B; Fleming, I; Harder, D; Medhora, M; Michaelis, UR | 1 |
| Dartt, DA; Hodges, RR; Tepavcevic, V; Zoukhri, D | 1 |
| Bringmann, A; Milenkovic, I; Reichenbach, A; Weick, M; Wiedemann, P | 1 |
| Chung, T; Dent, P; Hagan, MP; Hinman, D; McKinstry, R; Yacoub, A | 1 |
| Lorita, J; Pareja, M; Ramírez, I; Sánchez, O; Soley, M | 1 |
| Chan, SY; Mak, KK | 1 |
| Ahmed, I; Drezner, MK; Gesty-Palmer, D; Luttrell, LM | 1 |
| Arbel, R; Ben-Bassat, H; Hartzstark, Z; Klein, BY; Laufer, N; Levitzki, R; Rojansky, N | 1 |
| Bernardino, CR; Chang, EL; Dartt, DA; Hodges, RR; Horikawa, Y; Rios, JD; Rubin, PA; Shatos, MA; Zoukhri, D | 1 |
| Amornphimoltham, P; Gutkind, JS; Nelkin, BD; Park, JI; Patel, V; Sriuranpong, V | 1 |
| Singer, M; Vargaftig, BB | 1 |
| Chen, Z; Rola-Pleszczynski, M; Stankova, J | 1 |
| Fung, KY; Hertz, L; Peng, L; Prévot, V; Yu, AC | 1 |
| Davidson, AJ; Goishi, K; Klagsbrun, M; Lee, P; Nishi, E; Zon, LI | 1 |
| Hidaka, K; Morisaki, T; Suk Kim, H | 1 |
| Amorino, GP; Contessa, JN; Dent, P; Hewit, TH; Lammering, G; Schmidt-Ullrich, RK; Valerie, K | 1 |
| Marcoux, N; Vuori, K | 1 |
| Abbou, CC; Chopin, DK; Daher, A; de Boer, WI; El-Marjou, A; Radvanyi, F; Thiery, JP; van der Kwast, T | 1 |
| Degen, SJ; Hill, KJ; Peace, BE; Waltz, SE | 1 |
| Chokki, M; Eguchi, H; Horiuchi, H; Kamimura, T; Masegi, T; Tanabe, H; Yamamura, S; Yasuoka, S | 1 |
| Gui, Y; Zheng, XL | 1 |
| El-kholy, W; MacDonald, PE; Targonsky, ED; Tsushima, RG; Wang, X; Wheeler, MB; Xia, F | 1 |
| Mattingly, RR; Menard, RE | 1 |
| Cheng, K; Raufman, JP; Zimniak, P | 1 |
| Barrett, KE; Bertelsen, LS; Keely, SJ | 1 |
| Burgess, AW; Johns, TG; Jungbluth, AA; Luwor, RB; Murone, C; Nice, EC; Old, LJ; Perera, RM; Scott, AM; Stockert, E; Vitali, AA; Walker, F; Weinstock, J | 1 |
| Berezin, V; Pedersen, MW; Pedersen, N; Poulsen, HS; Tkach, V | 1 |
| Ashida, M; Bito, T; Budiyanto, A; Ichihashi, M; Kunisada, M; Ueda, M | 1 |
| González, A; Guerrero, J; Martínez, J; Santibañez, JF | 1 |
| Klumpp, A; Steinbach, JP; Weller, M; Wolburg, H | 1 |
| Darmoul, D; Devaud, H; Gratio, V; Laburthe, M | 1 |
| Brandes, RP; Busse, R; Geiger, H; Jung, O; Pedrazzini, T; Schreiber, JG | 1 |
| Berk, BC; Lungu, AO; Tanimoto, T | 1 |
| Dowlati, A; Kern, JA; Nethery, D | 1 |
| Arany, I; Kaneto, H; Megyesi, JK; Price, PM; Safirstein, RL | 1 |
| Chan, AS; Wong, YH | 1 |
| Ben-Bassat, H; Hartzstark, Z; Klein, BY; Laufer, N; Levitzki, R; Rojansky, N; Shlomai, Z; Shushan, A | 1 |
| Prydz, H; Wiiger, MT | 1 |
| Evdonin, AL; Margulis, BA; Medvedeva, ND; Tsupkina, NV | 1 |
| Adachi, T; Chihara, J; Cui, CH; Kanda, A; Kayaba, H; Ohta, K | 1 |
| Brown, EM; Chattopadhyay, N; MacLeod, RJ; Yano, S | 1 |
| Chen, R; Morinelli, TA; Paul, RV; Ullian, ME; Webb, JG | 1 |
| Kataoka, K; Kurabayashi, T; Kuribayashi, A; Miura, M | 1 |
| Barki-Harrington, L; El-Shewy, HM; Kelly, FL; Luttrell, LM | 1 |
| De Tribolet, N; Diserens, AC; Godard, S; Hamou, MF; Hegi, ME; Kobayashi, H; Lachat, Y; Nozaki, M | 1 |
| Abulrob, A; Andrade, MF; Giuseppin, S; McDermid, A; Moreno, M; Stanimirovic, D | 1 |
| Abraham, S; Egan, LJ; Myhre, GM; Toruner, M | 1 |
| Liu, B; Neufeld, AH | 1 |
| Basuroy, S; Rao, RK; Seth, A; Sheth, P | 1 |
| Götte, M; Kresse, H; Sofeu Feugaing, DD | 1 |
| Bowling, GH; Khan, SA; Millena, AC; Reddy, SC | 1 |
| Chen, Z; Grandis, JR; Li, M; Shin, DM; Wang, Z; Wieand, HS; Zhang, X | 1 |
| Franklin, RA; McCubrey, JA; McMahon, M; Shelton, JG; Sreevalsan, T; Steelman, LS | 1 |
| Gavard, J; Mège, RM; Monnet, C; Sobel, A | 1 |
| Chalothorn, D; Faber, JE; Jackson, LF; Lee, DC; Zhang, H | 1 |
| Kolachana, P; Lawsin, LM; Moore, J; Perlman, A; Ringel, MD; Saji, M | 1 |
| Campadelli-Fiume, G; Gianni, T; Menotti, L | 1 |
| Bronk, SF; Gores, GJ; Gwak, GY; Lee, HS; Werneburg, NW; Yoon, JH | 1 |
| Bernd, A; Guschel, M; Kaufmann, R; Kippenberger, S; Knies, Y; Loitsch, S; Müller, J | 1 |
| Chen, QM; Purdom, S | 1 |
| Higgins, CE; Higgins, PJ; Higgins, SP; Kutz, SM; Samarakoon, R | 1 |
| Davidson, C; Davidson, WR; Dicker, AP; Farber, SA; McAleer, MF; Rodeck, U; Yentzer, B | 1 |
| Abud, HE; Heath, JK; Watson, N | 1 |
| Condeelis, J; Coniglio, S; Eddy, R; Kempiak, S; Lorenz, M; Miki, H; Sarmiento, C; Segall, J; Symons, M; Takenawa, T; Yamaguchi, H | 1 |
| Ishii, T; Masuda, M; Matsuse, T; Teramoto, S | 1 |
| Bertrand, FE; Green, TD; McCubrey, JA; Spengeman, JD | 1 |
| Long, HC; Wang, G; Wang, ZH; Wang, ZL; Xiao, BR | 1 |
| Cheng, J; Chu, EK; Drazen, JM; Foley, JS; Patel, AS; Tschumperlin, DJ | 1 |
| Kanje, M; Nilsson, A | 1 |
| Chen, L; Gao, P; Ma, D; Oppenheim, JJ; Sun, R; Wang, J; Zhang, N | 1 |
| Akhtar, S; Benter, IF; Yousif, MH | 1 |
| Bagnato, A; Di Castro, V; Elia, G; Natali, PG; Rosanò, L; Spinella, F | 1 |
| Beaucage, P; Moreau, P | 1 |
| Akhtar, S; Benboubetra, M; Benter, IF; Griffiths, SM; Yousif, MH | 1 |
| Buck, DC; Macey, TA; Neve, KA; Wang, C; Yang, R | 1 |
| Boulesteix, C; Gall, L; Germain, G; Ruffini, S | 1 |
| Carbone, DP; Dang, TP; Eichenberger, S; Gonzalez, A; Haruki, N; Kawaguchi, KS; Massion, PP; Olson, S | 1 |
| El-Abaseri, TB; Fuhrman, J; Hansen, LA; Shendrik, I; Tennant, RW; Trempus, C | 1 |
| Chan, CT; Kane, SE; Metz, MZ | 1 |
| Baibakov, G; Emmert-Buck, MR; Gutkind, JS; Knezevic, V; Patel, V; Ramesh, A; Traicoff, JL | 1 |
| Burgess, AW; Clayton, AH; Nice, EC; Perugini, MA; Rothacker, J; Watson, KG; Weinstock, J | 1 |
| Neufeld, AH; Zhang, X | 1 |
| Delamere, NA; Tamiya, S | 1 |
| Catt, KJ; Chu, DB; Neithardt, A; Shah, BH; Shah, FB | 1 |
| Fujioka, A; Itoh, RE; Kurokawa, K; Matsuda, M; Mayer, BJ; Sharma, A | 1 |
| Chicoine, LG; English, BK; Liu, Y; Nelin, LD; Reber, KM; Young, TL | 1 |
| Brattain, MG; Zhou, Y | 1 |
| Bao, Y; Ding, YB; Li, XY; Shi, RH; Tong, JD; Wang, XH; Wu, J; Xiao, WM; Yan, ZG; Yang, JG; Zhang, GX | 1 |
| Halgunset, J; Larsson, E; Skogseth, H | 3 |
| Bigner, DD; Kwatra, MM; Richardson, MD; Yamaguchi, K | 1 |
| El Shewy, H; Gesty-Palmer, D; Kohout, TA; Luttrell, LM | 1 |
| Jones, PL; Martinez, EC; Merklinger, SL; Rabinovitch, M | 1 |
| Egami, H; Hirota, M; Ogawa, M; Takai, E; Tamori, Y; Tan, X | 1 |
| Churg, A; Vincent, R; Wang, RD; Wang, X; Xie, C | 1 |
| Finlay, D; Furlong, F; Martin, F | 1 |
| Bunting, M; Hanson, BJ; Hanson, GT; O'Grady, M; Raha, D | 1 |
| Brechbiel, MW; Burgess, AW; Hall, C; Johns, TG; Kelly, MP; Lee, FT; Mountain, AJ; Nice, EC; Rigopoulos, A; Scott, AM; Smyth, FE | 1 |
| Atwal, J; Chen, DF; Cho, KS; Gore, B; He, Z; Kim, JA; Koprivica, V; Lin, E; Park, JB; Tessier-Lavigne, M; Yiu, G | 1 |
| Mariappa, D; Seshagiri, PB; Shivaji, S; Siva, AB | 1 |
| Kitayama, J; Mori, K; Nagawa, H; Shida, D; Watanabe, T | 1 |
| Higashiyama, S; Itoh, M; Joh, T; Kataoka, H; Nakao, H; Ohhara, H; Ohshima, T; Sasaki, M; Tanida, S; Watanabe, K | 1 |
| Kitayama, J; Mori, K; Nagawa, H; Shida, D; Watanabe, T; Yamashita, H | 1 |
| Abe, M; Egami, H; Hirota, M; Nozawa, F; Ogawa, M; Tan, X | 1 |
| Kim, SY; Kim, YK; Kwon, CH; Lee, JS | 1 |
| Kim, HJ; Kim, JH | 1 |
| Bertagnolli, MM; Carothers, AM; Hunt, DH; Javid, SH; Moran, AE; Redston, M | 1 |
| Fishman, DA; Kang, S; Luo, R; Meng, Y; Smicun, Y | 1 |
| Brattain, MG; Conway, AN; Hauser, J; Hu, YP; Humphrey, L; Li, S; Vinci, MA; Wang, J; Willson, JK; Zborowska, E; Zhou, Y | 1 |
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| Beaulieu Leclerc, V; Proulx, S; Roy, O; Santerre, K | 1 |
| Araujo Vieira, I; Brufatto Olguins, D; Brunetto de Farias, C; José Gregianin, L; Kersting, N; Kunzler Souza, B; Lunardi Brunetto, A; Pereira Dos Santos, R; Roesler, R; Schwartsmann, G; Tesainer Brunetto, A | 1 |
| Gao, MY; Lin, C; Qin, Y; Wang, YF; Zhang, H | 1 |
| Gao, H; Gui, S; Jin, L; Kang, J; Liu, Q; Yuan, T; Zhang, J; Zhang, Y | 1 |
| Han, J; Jiang, L; Jin, Z; Lou, D; Qian, Y; Xu, J; Yang, Y; Yu, Q; Zhou, L | 1 |
| Akin, JW; Brännström, M; Choi, Y; Curry, TE; Jo, M; Rosewell, KL | 1 |
| Chen, H; Ju, X; Song, Z; Wang, Y; Wu, W; Yan, T; Yang, X; Zhang, Z | 1 |
| Li, J; Liu, Y; Lu, J; Peng, Z; Zhang, L | 1 |
| Kanamura, N; Marunaka, R; Marunaka, Y; Taruno, A; Yamamoto, T | 1 |
| Kanamaru, H; Kawakita, F; Liu, L; Nakano, F; Nakatsuka, Y; Nishikawa, H; Okada, T; Pak, S; Shiba, M; Suzuki, H | 1 |
| Chen, XW; Geng, F; Liu, JY; Lu, GF; Peng, C; Rodriguez, G; Tian, J; Wu, JL; Zou, WJ | 1 |
| Deng, Q; Li, B; Li, P; Liu, H; Liu, J; Wei, Z; Yan, J; Zhang, Z | 1 |
| Barros Nunes, G; Chediek Dall'Acqua, P; Fábio Gouveia Nogueira, M; Fontes, PK; Lombardi Lopes, F; Marinho, M; Rodrigues da Silva, C; Zoccal Mingoti, G | 1 |
| Elze, L; Gerlach, JP; Heuts, BMH; Hogeweg, M; Huck, WTS; Mulder, KW; Muraro, MJ; Rakszewska, A; Rivello, F; Stunnenberg, HG; Tanis, SEJ; van Buggenum, JAG; van Oudenaarden, A | 1 |
| Liu, B; Tian, T; Yang, B; Yao, Y; Zhang, K | 1 |
| Chen, R; Hei, Y; Liu, W; Long, Q; Mao, X; Wang, J | 1 |
| Bajo, AM; Carmena, MJ; Muñoz-Moreno, L; Prieto, JC; Schally, AV | 1 |
| Dai, H; Jia, G; Wang, R; Yue, Y | 1 |
| Chen, L; Du, L; Li, H; Xie, S; Zhang, L; Zhang, X | 1 |
| Azuma, M; Kim, M; Ko, S; Lee, DA; Lee, SH; Park, H; Parsons, MJ; Prober, D; Shin, D; So, J | 1 |
| Bambini, V; Brunetto, AT; de Farias, CB; Freire, NH; Jaeger, M; Metcalfe, VA; Pinheiro, KV; Roesler, R; Shaw, L; Smith, CGS; Souza, BK; Thomaz, A | 1 |
| Huang, J; Ji, D; Lei, H; Li, H; Rong, R; Tang, L; Wu, J; Wu, W; Xia, X; Xiong, K; You, M; Zeng, Z | 1 |
| Akashi, M; Fukuoka, T; Hasegawa, T; Kakei, Y; Kashin, M; Sasaki, R; Teraoka, S; Yamaguchi, A | 1 |
| Felder, RB; Wei, SG; Yu, Y | 1 |
| Chen, Z; Hu, R; Jiang, H; Sun, Y; Yan, J; Yang, Y | 1 |
| Bian, X; Li, X; Sun, Y; Tian, W; Tian, Y; Xu, J; Zhao, H | 1 |
| Chu, HW; Davis-Hall, D; Dobrinskikh, E; Magin, CM; Michalski, JE; Park, JA; Schwartz, DA; Smith, BJ; Stancil, IT; Yang, IV | 1 |
| Hu, R; Jiang, H; Li, W; Sun, Y; Wang, Z; Yan, J; Yang, Y | 1 |
| Akudugu, JM; Hamid, MB; Serafin, AM | 1 |
| Bondy, C; Chen, Y; Luo, Q; Wang, J; Zhou, X; Zhu, L | 1 |
3 review(s) available for rtki cpd and quinazolines
| Article | Year |
|---|---|
Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications.
Topics: Apoptosis; Drug Resistance, Neoplasm; ErbB Receptors; Glioma; Humans; Mutation; Quinazolines; Signal Transduction; Tyrphostins | 2001 |
The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.
Topics: Autocrine Communication; Benzothiazoles; Breast Neoplasms; Carcinoma; Epidermal Growth Factor; ErbB Receptors; Female; Genes, erbB; Growth Substances; Humans; Neuregulin-1; Quinazolines; Radiation, Ionizing; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2001 |
Modulation of the oncogene-dependent tissue factor expression by kinase suppressor of ras 1.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Factor VIIa; Genes, ras; Humans; Mice; Mice, SCID; Morpholines; Neoplasms; Oncogenes; Phosphotransferases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Thromboplastin; Trastuzumab; Tyrphostins; Up-Regulation | 2010 |
719 other study(ies) available for rtki cpd and quinazolines
| Article | Year |
|---|---|
Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors.
Topics: Benzylidene Compounds; Cell Division; Enzyme Inhibitors; ErbB Receptors; Gene Amplification; Glioma; Humans; Mutation; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrphostins | 1996 |
Inhibition of gastric mucosal regeneration by tyrphostin: evaluation of the role of epidermal growth factor receptor tyrosine kinase.
Topics: Animals; Benzylidene Compounds; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Male; Mucous Membrane; Nitriles; Proliferating Cell Nuclear Antigen; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Inbred F344; Regeneration; Stomach; Tyrphostins | 1996 |
Growth inhibition of human lung adenocarcinoma cells by antibodies against epidermal growth factor receptor and by ganglioside GM3: involvement of receptor-directed protein tyrosine phosphatase(s).
Topics: Adenocarcinoma; Benzylidene Compounds; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Membrane; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Humans; Lung Neoplasms; Nitriles; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Radioligand Assay; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1997 |
Inhibition of tyrosine kinase activity decreases expression of surfactant protein A in a human lung adenocarcinoma cell line independent of epidermal growth factor receptor.
Topics: Benzylidene Compounds; Binding, Competitive; Blotting, Northern; Blotting, Western; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Lung; Lung Neoplasms; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinazolines; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins | 1997 |
Opposing effects of tyrosine kinase inhibitors on mineralization of normal and tumor bone cells.
Topics: Alkaline Phosphatase; Animals; Benzylidene Compounds; Bone Marrow; Bone Neoplasms; Calcification, Physiologic; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Nitriles; Osteosarcoma; Protein-Tyrosine Kinases; Quinazolines; Rats; Stem Cells; Stromal Cells; Tumor Cells, Cultured; Tyrphostins | 1997 |
Tyrphostin AG 494 blocks Cdk2 activation.
Topics: 3T3 Cells; Acrylamides; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Mice; Molecular Structure; Nitriles; Protein Serine-Threonine Kinases; Quinazolines; Tyrphostins | 1997 |
Two- and three-dimensional cell structures govern epidermal growth factor survival function in human bladder carcinoma cell lines.
Topics: Apoptosis; Culture Media, Serum-Free; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Neoplasm Proteins; Nitriles; Protein-Tyrosine Kinases; Quinazolines; Spheroids, Cellular; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Urinary Bladder Neoplasms | 1997 |
Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site.
Topics: Adenosine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Binding Sites; Carrier Proteins; Dimerization; Enzyme Inhibitors; ErbB Receptors; Glycoproteins; Humans; Ligands; Neuregulin-1; Nitriles; Phosphorylation; Protein Binding; Protein Conformation; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1997 |
Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes.
Topics: Antibodies; Apoptosis; Benzylidene Compounds; Cell Cycle; Cell Differentiation; Cell Division; Cell Line, Transformed; Cyclin-Dependent Kinases; Enzyme Inhibitors; ErbB Receptors; Filaggrin Proteins; Humans; Keratinocytes; Nitriles; Papillomaviridae; Phosphorylation; Quinazolines; Tyrphostins | 1997 |
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation.
Topics: Breast Neoplasms; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Division; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Nitriles; Phospholipase C gamma; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Quinazolines; Radiation, Ionizing; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrphostins | 1997 |
EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney.
Topics: Animals; Aprotinin; Cell Line; Coculture Techniques; Collagen; Cysteine Proteinase Inhibitors; Embryonic Induction; Enzyme Inhibitors; Epithelium; ErbB Receptors; Hepatocyte Growth Factor; Kidney; Kidney Medulla; Kidney Tubules, Collecting; Leucine; Ligands; Mice; Mice, Knockout; Morphogenesis; Nitriles; Phenanthrolines; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Quinazolines; Receptor Protein-Tyrosine Kinases; Transforming Growth Factor alpha; Tyrphostins | 1997 |
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Androstadienes; Aspartic Acid Endopeptidases; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Inositol; Inositol Phosphates; Maleimides; Nitriles; Phosphatidylinositols; Phosphotyrosine; Protein Kinase C; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Wortmannin | 1997 |
Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activated ras-stimulated intestinal epithelial cells.
Topics: Amphiregulin; Animals; Apoptosis; Autocrine Communication; Betacellulin; Cell Division; Cells, Cultured; Chlorates; Culture Media, Conditioned; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Nitriles; Phosphorylation; Polysaccharide-Lyases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; ras Proteins; Rats; RNA; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation | 1997 |
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Decorin; Enzyme Activation; ErbB Receptors; Extracellular Matrix Proteins; Humans; Mice; Nitriles; Phosphorylation; Proteoglycans; Quinazolines; Tumor Cells, Cultured; Tyrphostins | 1998 |
Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor.
Topics: 3T3 Cells; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Down-Regulation; Enzyme Activation; ErbB Receptors; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Transfection; Tyrphostins | 1998 |
Decorin activates the epidermal growth factor receptor and elevates cytosolic Ca2+ in A431 carcinoma cells.
Topics: Calcium; Cell Division; Cytosol; Decorin; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Humans; Nitriles; Proteoglycans; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1998 |
Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.
Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Aorta, Thoracic; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GRB2 Adaptor Protein; Muscle, Smooth, Vascular; Nitriles; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; Rats, Sprague-Dawley; src Homology Domains; Tyrphostins | 1998 |
Effect of tyrosine kinase inhibition on surfactant protein A gene expression during human lung development.
Topics: Embryonic and Fetal Development; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genistein; Homeostasis; Humans; Lung; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinazolines; RNA, Messenger; Tyrosine; Tyrphostins | 1998 |
Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Caspase 3; Caspases; Cisplatin; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; ErbB Receptors; Glioblastoma; Humans; Nitriles; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tumor Cells, Cultured; Tyrphostins | 1998 |
Endothelin-1 stimulates DNA synthesis of vascular smooth-muscle cells through transactivation of epidermal growth factor receptor.
Topics: Animals; Biotransformation; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Male; Muscle, Smooth, Vascular; Nitriles; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-fos; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins | 1998 |
Activation of NF-kappa B by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade.
Topics: 3T3 Cells; Animals; Autocrine Communication; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; ErbB Receptors; Gene Expression Regulation; Genes, Reporter; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; Nitriles; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Suramin; Tyrphostins | 1998 |
Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 2; GTP-Binding Proteins; Ionomycin; Models, Biological; Nitriles; PC12 Cells; Phorbol Esters; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Quinazolines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Tyrphostins; Ubiquitin-Protein Ligases; Uridine Triphosphate | 1998 |
Opposing effects of cyclosporin A and tyrphostin AG-1478 indicate a role for Src protein in the cellular control of mineralization.
Topics: Animals; Calcification, Physiologic; Cell Differentiation; Cells, Cultured; Cyclosporine; Dexamethasone; Enzyme Inhibitors; Female; Phosphorylation; Proteins; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; Rats, Inbred Strains; Stromal Cells; Tyrosine; Tyrphostins | 1998 |
Epidermal growth factor (EGF) modulates fetal thymocyte growth and differentiation: partial reversal by insulin, mimicking by specific inhibitors of EGF receptor tyrosine kinase activity, and differential expression of CD45 phosphatase isotypes.
Topics: Animals; Cell Differentiation; Cell Division; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fetus; Growth Inhibitors; Immunophenotyping; Insulin; Isoenzymes; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Molecular Mimicry; Nitriles; Organ Culture Techniques; Quinazolines; Solubility; T-Lymphocyte Subsets; Thymus Gland; Tyrphostins | 1998 |
Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Chlorides; Colon; ErbB Receptors; GRB2 Adaptor Protein; Intestinal Mucosa; Phosphorylation; Protein Binding; Protein Kinase C; Proteins; Quinazolines; Receptor, Muscarinic M3; Receptors, Muscarinic; Shc Signaling Adaptor Proteins; Signal Transduction; Transcriptional Activation; Tyrphostins | 1998 |
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells.
Topics: Acute-Phase Proteins; Animals; bcl-X Protein; Cell Line; Cell Survival; Cell Transformation, Neoplastic; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Intestinal Mucosa; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Rats; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrphostins | 1998 |
Chronic ethanol consumption disrupts complexation between EGF receptor and phospholipase C-gamma1: relevance to impaired hepatocyte proliferation.
Topics: Animals; Calcium Signaling; Cell Division; Cells, Cultured; Cytoskeleton; Cytosol; DNA; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Ethanol; Isoenzymes; Liver; Male; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; Quinazolines; Rats; Rats, Wistar; Type C Phospholipases; Tyrphostins | 1999 |
ERK MAP kinase activation is required for acetylcholine receptor inducing activity-induced increase in all five acetylcholine receptor subunit mRNAs as well as synapse-specific expression of acetylcholine receptor epsilon-transgene.
Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Lac Operon; Mice; Muscle Fibers, Skeletal; Phosphatidylinositol 3-Kinases; Quinazolines; Receptors, Cholinergic; RNA, Messenger; Sirolimus; Synapses; Transcription, Genetic; Transgenes; Tyrphostins; Up-Regulation; Wortmannin | 1999 |
Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; ErbB Receptors; Focal Adhesion Kinase 2; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligopeptides; PC12 Cells; Peptide Fragments; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; src-Family Kinases; Tyrphostins | 1999 |
Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation.
Topics: Actins; Animals; Calcium; Cyclic AMP; Cytoskeleton; ErbB Receptors; Fibroblasts; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Ligands; Lysophospholipids; Mice; Mice, Knockout; Microinjections; Proto-Oncogene Proteins; Quinazolines; Receptors, Cell Surface; Signal Transduction; Thrombin; Tyrphostins | 1999 |
4-hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition.
Topics: Aldehydes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cross-Linking Reagents; Enzyme Activation; ErbB Receptors; Genistein; Humans; Lipid Peroxidation; Oxidative Stress; Phosphoproteins; Phosphorylation; Quinazolines; Signal Transduction; Tyrosine; Tyrphostins | 1999 |
Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats.
Topics: Animals; Collagen; Enzyme Inhibitors; ErbB Receptors; Lung; Mitosis; Phosphorylation; Pulmonary Fibrosis; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Tyrphostins | 1999 |
Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Colorectal Neoplasms; DNA, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Humans; Membrane Proteins; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1999 |
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1999 |
Nitric oxide inhibits angiotensin II-induced activation of the calcium-sensitive tyrosine kinase proline-rich tyrosine kinase 2 without affecting epidermal growth factor receptor transactivation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; ErbB Receptors; Focal Adhesion Kinase 2; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitroprusside; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Quinazolines; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcriptional Activation; Tyrphostins | 1999 |
Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Chromones; Cytochalasin D; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mice; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-3; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Transfection; Tyrphostins | 1999 |
Ionizing radiation stimulates existing signal transduction pathways involving the activation of epidermal growth factor receptor and ERBB-3, and changes of intracellular calcium in A431 human squamous carcinoma cells.
Topics: Calcium; Carcinoma, Squamous Cell; Enzyme Inhibitors; ErbB Receptors; Estrenes; Humans; Phosphodiesterase Inhibitors; Phosphorylation; Pyrrolidinones; Quinazolines; Receptor, ErbB-3; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1999 |
Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors.
Topics: Animals; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermis; ErbB Receptors; Humans; Keratinocytes; Mice; Psoriasis; Quinazolines; Skin Absorption; Tumor Cells, Cultured; Tyrphostins | 1999 |
Activation of tyrosine kinases by alpha1A-adrenergic and growth factor receptors in transfected PC12 cells.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Differentiation; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GRB2 Adaptor Protein; GTP-Binding Proteins; Mitogen-Activated Protein Kinases; Norepinephrine; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Signal Transduction; Transfection; Tyrphostins | 1999 |
Phorbol ester reduces phosphorylation of epidermal growth factor receptor in pancreatic cancer cells by activation of a tyrosine phosphatase.
Topics: Cell Membrane; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Kinetics; Organometallic Compounds; Pancreatic Neoplasms; Phenanthrolines; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrphostins | 1999 |
Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line.
Topics: Animals; Cell Division; Cell Line, Transformed; Chemotaxis; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Matrix; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Genistein; Growth Substances; Hepatocyte Growth Factor; Insulin-Like Growth Factor I; Intestines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Quinazolines; Transforming Growth Factor beta; Type C Phospholipases; Tyrphostins | 1999 |
Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt.
Topics: Angiotensin II; Animals; Calcium; CHO Cells; Cricetinae; ErbB Receptors; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; ras Proteins; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Transcriptional Activation; Tyrphostins | 1999 |
Fluid flow-induced tyrosine phosphorylation and participation of growth factor signaling pathway in osteoblast-like cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blotting, Western; Cell Line; Culture Media; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Gene Expression Regulation; Immediate-Early Proteins; Mice; Mitogen-Activated Protein Kinase 1; Osteoblasts; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Quinazolines; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Stress, Mechanical; Transcription Factors; Tyrosine; Tyrphostins | 2000 |
Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium; Cell Division; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GRB2 Adaptor Protein; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Physical Stimulation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; Rats; Rats, Sprague-Dawley; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Tyrphostins | 2000 |
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clathrin; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; GTP-Binding Proteins; Isoproterenol; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Cell Surface; Transfection; Tyrphostins | 2000 |
A role for bovine herpesvirus 1 (BHV-1) glycoprotein E (gE) tyrosine phosphorylation in replication of BHV-1 wild-type virus but not BHV-1 gE deletion mutant virus.
Topics: Animals; Capsid; Cell Line; Dogs; Gene Deletion; Genistein; Herpesvirus 1, Bovine; Mutation; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Quinazolines; Tyrphostins; Viral Envelope Proteins; Viral Proteins; Virus Replication | 2000 |
Role of transforming growth factor-alpha and the epidermal growth factor receptor in embryonic rat testis development.
Topics: Animals; Animals, Newborn; Antibody Specificity; Cell Division; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation, Developmental; Male; Mice; Mice, Knockout; Quinazolines; Rats; Rats, Sprague-Dawley; Testis; Transforming Growth Factor alpha; Tyrphostins | 2000 |
Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines.
Topics: Cell Division; Dihydrotestosterone; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2000 |
Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity.
Topics: Animals; Cell Cycle Proteins; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Female; G1 Phase; Humans; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Retinoblastoma Protein; Tumor Suppressor Proteins; Tyrphostins; Up-Regulation | 2000 |
The mitogen-activated protein kinase cascade mediates neurotrophic effect of epidermal growth factor in cultured rat hippocampal neurons.
Topics: Animals; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hippocampus; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tyrphostins | 2000 |
Calcium channel antagonist effect on in vitro meningioma signal transduction pathways after growth factor stimulation.
Topics: Adult; Aged; Blood Physiological Phenomena; Calcium; Calcium Channel Blockers; Culture Techniques; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Growth Substances; Humans; Inositol Phosphates; Intracellular Membranes; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Quinazolines; Signal Transduction; Type C Phospholipases; Tyrphostins | 2000 |
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.
Topics: Animals; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-met; Quinazolines; Rats; Receptor Cross-Talk; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 2000 |
Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC12 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Nitrates; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Quinazolines; Rats; src-Family Kinases; Tyrphostins | 2000 |
Role of basal calcium in the EGF activation of MAP kinases.
Topics: Animals; Calcium; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Isoenzymes; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipase C gamma; Protein Tyrosine Phosphatases; Quinazolines; Type C Phospholipases; Tyrphostins | 2000 |
Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src).
Topics: Calcium; Carbachol; Cell Line; Chlorides; Colon; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Fluphenazine; Focal Adhesion Kinase 2; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Signal Transduction; Thapsigargin; Time Factors; Transcriptional Activation; Tyrphostins | 2000 |
Mechanism of extracellular signal-regulated kinase (ERK)-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibroblasts.
Topics: Acetylcysteine; Animals; Asthma; Bronchitis; Carbon; Coal Ash; Colforsin; Enzyme Activation; ErbB Receptors; Fibroblasts; Flavonoids; Intracellular Signaling Peptides and Proteins; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Particulate Matter; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Quinazolines; Rats; Titanium; Tyrphostins; Vanadium Compounds | 2000 |
Activation of epidermal growth factor receptor during corneal epithelial migration.
Topics: Amphiregulin; Animals; Binding Sites; Cell Movement; Debridement; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium, Corneal; ErbB Receptors; Female; Fluorescent Antibody Technique, Indirect; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Organ Culture Techniques; Phosphorylation; Precipitin Tests; Quinazolines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrphostins; Wound Healing | 2000 |
Receptor tyrosine kinase inhibition suppresses growth of pediatric renal tumor cells in vitro.
Topics: Adult; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Genistein; Humans; Infant; Kidney Neoplasms; Male; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Quinazolines; Receptor Protein-Tyrosine Kinases; Rhabdoid Tumor; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrphostins; Wilms Tumor | 2000 |
Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor.
Topics: Animals; Anticoagulants; Aorta; Becaplermin; Cell Line; Cell Movement; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Papio; Phenylalanine; Phosphorylation; Platelet-Derived Growth Factor; Protease Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; Thiophenes; Thrombin; Tyrphostins | 2000 |
Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; Female; HL-60 Cells; Humans; Microtubules; Mitosis; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Tyrphostins | 2000 |
Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice.
Topics: Animals; Butadienes; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Dimerization; DNA; Down-Regulation; ErbB Receptors; Female; Humans; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nitriles; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins | 2000 |
Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells.
Topics: Antineoplastic Agents; Butadienes; Carcinoma; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-met; Quinazolines; RNA, Messenger; Suramin; Thyroid Neoplasms; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 2000 |
Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Cell Line; Cell Membrane; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Norepinephrine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; Staurosporine; Time Factors; Transfection; Tyrphostins; Wortmannin | 2000 |
Thyrotropin-releasing hormone stimulates phosphorylation of the epidermal growth factor receptor in GH3 pituitary cells.
Topics: Animals; Enzyme Inhibitors; ErbB Receptors; Genes, Reporter; Indoles; Luciferases; Maleimides; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Pituitary Neoplasms; Protein Kinase C; Quinazolines; Rats; Recombinant Proteins; Thyrotropin-Releasing Hormone; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrphostins | 2000 |
Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Division; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Ovarian Neoplasms; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proteins; Quinazolines; Receptor, Endothelin A; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2000 |
Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.
Topics: Alkaline Phosphatase; Biological Transport; Breast Neoplasms; Cell Nucleus; Chromones; Cytoplasm; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Macromolecular Substances; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Quinazolines; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tyrphostins; Ubiquitin-Protein Ligases | 2000 |
Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.
Topics: Animals; Breast Neoplasms; Butadienes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Gene Expression; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Tamoxifen; Transcription, Genetic; Tyrphostins; Xenograft Model Antitumor Assays | 2000 |
Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression.
Topics: Amphiregulin; Animals; Betacellulin; Butylhydroxybutylnitrosamine; Carcinogens; Disease Progression; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Tyrphostins | 2000 |
Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation.
Topics: Angiopoietin-1; Angiopoietin-2; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cells, Cultured; Cornea; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Imidazoles; In Vitro Techniques; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Maleimides; Membrane Glycoproteins; Naphthalenes; Neovascularization, Physiologic; Olmesartan Medoxomil; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proteins; Pyridines; Quinazolines; Rabbits; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, TIE-2; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, TIE; RNA Stability; RNA, Messenger; Tetrazoles; Time Factors; Transcriptional Activation; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
A role for decorin in the structural organization of periodontal ligament.
Topics: 3T3 Cells; Aging; Animals; Cell Division; Decorin; Enzyme Inhibitors; Extracellular Matrix Proteins; Female; Male; Mice; Mice, Knockout; Microscopy, Electron; Microscopy, Electron, Scanning; Periodontal Ligament; Proteoglycans; Quinazolines; Recombinant Proteins; Transfection; Transforming Growth Factor beta; Tyrphostins | 2000 |
Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells.
Topics: Animals; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Ceramides; Chromones; Enzyme Activation; Guinea Pigs; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Quinazolines; Respiratory System; Signal Transduction; Sphingosine; Tyrphostins | 2000 |
STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma.
Topics: Cell Transformation, Neoplastic; Dimethyl Sulfoxide; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Interferon-alpha; Interferon-gamma; Jurkat Cells; Leukemia-Lymphoma, Adult T-Cell; Mutation; Mycosis Fungoides; Neoplasm Proteins; Protein Biosynthesis; Proteins; Quinazolines; Recombinant Fusion Proteins; Repressor Proteins; RNA, Messenger; RNA, Neoplasm; Sezary Syndrome; Skin Neoplasms; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tyrphostins | 2001 |
N-acetylcysteine inhibits angiotensin ii-mediated activation of extracellular signal-regulated kinase and epidermal growth factor receptor.
Topics: Acetylcysteine; Angiotensin II; Animals; Antioxidants; Blotting, Western; Calcimycin; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Hydrogen Peroxide; Immunoblotting; Ionophores; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth; Phosphorylation; Precipitin Tests; Pyrimidines; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Transcriptional Activation; Tyrphostins | 2001 |
BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoblotting; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuregulin-1; Organic Chemicals; Phosphorylation; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Recombinant Proteins; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 2001 |
Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.
Topics: Blotting, Western; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Interleukin-1; Keratinocytes; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Models, Biological; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinazolines; Time Factors; Tyrphostins | 2001 |
Sphingosine 1-phosphate activates Erk-1/-2 by transactivating epidermal growth factor receptor in rat-2 cells.
Topics: 3T3 Cells; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; HeLa Cells; History, Medieval; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pertussis Toxin; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Quinazolines; Rats; Signal Transduction; Sphingosine; Time Factors; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella | 2000 |
Tyrosine kinase involvement in renal arteriolar constrictor responses to angiotensin II.
Topics: Angiotensin II; Animals; Enalaprilat; Enzyme Inhibitors; ErbB Receptors; In Vitro Techniques; Male; Microscopy, Video; Perfusion; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Renal Artery; Signal Transduction; Tyrphostins; Vasoconstriction | 2001 |
Activation of endogenous thrombin receptors causes clustering and sensitization of epidermal growth factor receptors of swiss 3T3 cells without transactivation.
Topics: 3T3 Cells; Animals; Cell Division; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; GTP-Binding Proteins; Luminescent Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phalloidine; Quinazolines; Receptor Cross-Talk; Receptors, Thrombin; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Thrombin; Transfection; Tyrphostins | 2001 |
c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aorta; Benzoquinones; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Genistein; GRB2 Adaptor Protein; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Pyrimidines; Quinazolines; Quinones; Rifabutin; Swine; Transcriptional Activation; Tyrphostins | 2001 |
Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.
Topics: Cell Division; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gastrin-Releasing Peptide; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Quinazolines; Substrate Specificity; Transcription Factor AP-1; Tumor Cells, Cultured; Tyrphostins | 2001 |
Thrombin-induced p38 mitogen-activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway.
Topics: Blotting, Western; Calcium; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GTP-Binding Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Quinazolines; Signal Transduction; Thrombin; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella | 2001 |
Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.
Topics: Apoptosis; Benzothiazoles; Breast; Cell Count; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Polychlorinated Dibenzodioxins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Messenger; Transforming Growth Factor alpha; Tyrphostins | 2001 |
High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma.
Topics: Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Enzyme Stability; ErbB Receptors; Freezing; Mice; Quinazolines; Reference Standards; Sensitivity and Specificity; Tyrphostins | 2001 |
Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism.
Topics: 3T3 Cells; Animals; Binding Sites; Blotting, Western; Bombesin; Calcium; Cell Line; COS Cells; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; GTP-Binding Proteins; Humans; Ligands; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Models, Theoretical; Pertussis Toxin; Phosphorylation; Protein Binding; Quinazolines; Rats; Receptors, Bombesin; Signal Transduction; Substance P; Time Factors; Tumor Cells, Cultured; Tyrphostins; Virulence Factors, Bordetella | 2001 |
Activation of extracellular-regulated kinases by normal and mutant EGF receptors.
Topics: Dimethyl Sulfoxide; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Mitogen-Activated Protein Kinases; Mutation; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Quinazolines; Tumor Cells, Cultured; Type C Phospholipases; Tyrphostins | 2001 |
Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse.
Topics: Animals; Antigens, CD; Calcium-Binding Proteins; Cell Adhesion; Cells, Cultured; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Genistein; Glutamic Acid; Hippocampus; Integrin beta3; Integrins; Intercellular Signaling Peptides and Proteins; Isoflavones; Membrane Glycoproteins; Models, Neurological; Nerve Tissue Proteins; Neurons; Oligopeptides; Peptides; Platelet Membrane Glycoproteins; Presynaptic Terminals; Protein Subunits; Quinazolines; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Synaptotagmin I; Synaptotagmins; Tyrphostins | 2001 |
Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.
Topics: bcl-X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Flavonoids; Humans; In Situ Nick-End Labeling; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins | 2001 |
EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells.
Topics: Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; G1 Phase; Growth Inhibitors; Humans; MAP Kinase Signaling System; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Nasopharyngeal Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins; Up-Regulation | 2001 |
Gi-mediated activation of the Syk kinase by the receptor mimetic basic secretagogues of mast cells: role in mediating arachidonic acid/metabolites release.
Topics: Animals; Arachidonic Acid; Calcium; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; ErbB Receptors; Exocytosis; GTP-Binding Protein alpha Subunits, Gi-Go; Intracellular Signaling Peptides and Proteins; Mast Cells; Mitogen-Activated Protein Kinases; p-Methoxy-N-methylphenethylamine; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Wistar; Receptors, IgE; src-Family Kinases; Syk Kinase; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella | 2001 |
Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM.
Topics: Air Pollutants, Occupational; Bronchi; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Interleukin-8; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Metallurgy; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinazolines; Respiratory Mucosa; RNA, Messenger; Signal Transduction; Tyrphostins; Utah | 2001 |
EGF receptor-ERK pathway is the major signaling pathway that mediates upregulation of aldose reductase expression under oxidative stress.
Topics: Aldehyde Reductase; Animals; Cell Line; Cell Survival; Diabetes Complications; Diabetes Mellitus; ErbB Receptors; Flavonoids; Free Radical Scavengers; Humans; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Oxidative Stress; Phthalazines; Protein Kinases; Quinazolines; Rats; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation | 2001 |
Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells.
Topics: Cell Division; Cell Line; Cell Survival; Diploidy; DNA-Binding Proteins; DNA, Antisense; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gene Expression; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Quinazolines; Transcription Factors; Tumor Suppressor Protein p53; Tyrphostins | 2001 |
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Cell-Free System; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Quinazolines; Receptor, Insulin; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Wortmannin | 2001 |
EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin.
Topics: 3T3 Cells; Animals; Bombesin; Bradykinin; Cell Cycle; Cell Division; Cell Line; Cyclin D1; Cyclin E; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; G1 Phase; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Quinazolines; Rats; Receptors, Bombesin; Recombinant Proteins; Transfection; Tyrphostins | 2001 |
ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways.
Topics: Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; G1 Phase; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins; Up-Regulation | 2001 |
Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor.
Topics: Animals; Brain Neoplasms; Cell Survival; Cisplatin; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Neoplasm Transplantation; Protein Tyrosine Phosphatases; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured; Tyrphostins | 2001 |
Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis.
Topics: Actins; Bacterial Adhesion; Cell Line; Cortactin; Cytoskeletal Proteins; Endothelium; Enzyme Activation; Enzyme Inhibitors; Fimbriae, Bacterial; Humans; Microfilament Proteins; Microscopy, Fluorescence; Neisseria meningitidis; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptor, ErbB-2; Signal Transduction; src-Family Kinases; Tyrphostins | 2001 |
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin | 2001 |
Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Ligands; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Phenylalanine; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Quinazolines; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes; Transcription Factor AP-1; Transcriptional Activation; Tyrphostins | 2001 |
cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells.
Topics: Antigens, Bacterial; Bacterial Proteins; Cell Line; Enzyme Activation; Epithelial Cells; ErbB Receptors; Gastric Mucosa; Gene Expression Regulation, Bacterial; Helicobacter pylori; Humans; Interleukin-8; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Transcriptional Activation; Tyrphostins | 2001 |
Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands.
Topics: Antigens, CD; Cell Adhesion; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix Proteins; Humans; Integrin alpha2; Ligands; Quinazolines; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 2002 |
Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channels, L-Type; Cells, Cultured; Cytochalasin D; Drug Evaluation, Preclinical; ErbB Receptors; Focal Adhesion Kinase 2; Mitogen-Activated Protein Kinases; Myocardium; Phosphorylation; Piperidines; Potassium Channel Blockers; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Quinidine; Rats; Rats, Wistar; Tetraethylammonium; Time Factors; Tyrphostins | 2001 |
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation.
Topics: Adult; Asthma; Cells, Cultured; Culture Media, Conditioned; Enzyme Inhibitors; Eosinophils; ErbB Receptors; Humans; Hypersensitivity; Middle Aged; Mucin 5AC; Mucins; Phosphorylation; Pulmonary Eosinophilia; Quinazolines; Respiratory Mucosa; RNA, Messenger; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation | 2001 |
Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-alpha.
Topics: Bronchi; Cell Division; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Humans; Interleukin-13; Models, Biological; Quinazolines; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins | 2001 |
Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor.
Topics: Animals; Astrocytes; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptides; Phosphatidylinositols; Phospholipase C beta; Phosphorylation; Protein Binding; Protein Subunits; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; src-Family Kinases; Transcriptional Activation; Type C Phospholipases; Tyrphostins | 2001 |
Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.
Topics: Animals; Aorta; Arginine; Calcium Signaling; Cells, Cultured; Chromones; Citrulline; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Kinetics; Morpholines; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Quinazolines; Signal Transduction; Swine; Tyrphostins | 2002 |
CD95-mediated apoptosis of human glioma cells: modulation by epidermal growth factor receptor activity.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Brain Neoplasms; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Survival; Coumarins; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Fas Ligand Protein; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Glioma; Humans; Membrane Glycoproteins; Oligopeptides; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Serpins; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrphostins; Viral Proteins | 2002 |
TGF-alpha-driven tumor growth is inhibited by an EGF receptor tyrosine kinase inhibitor.
Topics: Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Division; DNA, Complementary; Enzyme Inhibitors; ErbB Receptors; Glioma; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; RNA; RNA, Messenger; Tetracycline; Time Factors; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2002 |
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.
Topics: Apoptosis; Arabidopsis Proteins; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Plant Proteins; Potassium Channels; Quinazolines; Receptor, IGF Type 1; Ribosomal Protein S6 Kinases; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2002 |
Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family.
Topics: Cell Cycle; Cell Line, Transformed; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Resistance, Neoplasm; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Neoplasm Proteins; Neoplasms; Pyrimidines; Quinazolines; Receptor, ErbB-2; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyrphostins | 2002 |
Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.
Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Genistein; Hydrogen Peroxide; Imidazoles; Immunoblotting; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Rats; Rats, Wistar; Sarcolemma; Signal Transduction; Sodium-Hydrogen Exchangers; src-Family Kinases; Tyrphostins | 2002 |
The role of Ral A in epidermal growth factor receptor-regulated cell motility.
Topics: Animals; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Neoplasm Metastasis; Quinazolines; ral GTP-Binding Proteins; Tumor Cells, Cultured; Tyrphostins; Urinary Bladder Neoplasms | 2002 |
Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes.
Topics: Angiotensin II; Animals; Arsenicals; Cell Line; Concanavalin A; COS Cells; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Hepatocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Quinazolines; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sucrose; Transfection; Tyrphostins | 2002 |
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
Topics: Animals; Cell Line; Colonic Neoplasms; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Gastric Mucosa; Genes, src; Humans; Hypertrophy; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitogen-Activated Protein Kinase 1; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Transcriptional Activation; Tyrphostins | 2002 |
Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.
Topics: Animals; Blotting, Western; Cell Line; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Quinazolines; Ribosomal Protein S6 Kinases; Signal Transduction; Transfection; Tyrosine; Tyrphostins; Ultraviolet Rays | 2001 |
Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts.
Topics: Animals; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Leukocyte Elastase; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tropoelastin; Tyrphostins | 2002 |
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Arachidonic Acid; Bacterial Proteins; Brimonidine Tartrate; Butadienes; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; MAP Kinase Signaling System; Matrix Metalloproteinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; Pertussis Toxin; Phosphorylation; Protein Binding; Proteins; Quinacrine; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Swine; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella | 2002 |
Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor.
Topics: Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Genistein; Kv1.5 Potassium Channel; Membrane Potentials; Patch-Clamp Techniques; Phenols; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein-Tyrosine Kinases; Quinazolines; Rats; Time Factors; Transfection; Tyrphostins | 2002 |
Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases.
Topics: Androstadienes; Animals; Cells, Cultured; DNA Replication; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibroblasts; Heart; Isoproterenol; Male; Mitogen-Activated Protein Kinases; Myocardium; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Tyrphostins; Virulence Factors, Bordetella; Wortmannin | 2002 |
Inhibitory effect and its kinetic analysis of tyrphostin AG1478 on recombinant human protein kinase CK2 holoenzyme.
Topics: Casein Kinase II; Caseins; DNA-Binding Proteins; Enzyme Inhibitors; Guanosine Triphosphate; Holoenzymes; Humans; Kinetics; Protein Serine-Threonine Kinases; Quinazolines; Recombinant Proteins; Tyrphostins | 2002 |
Role of calmodulin in the modulation of the MAPK signalling pathway and the transactivation of epidermal growth factor receptor mediated by PKC.
Topics: Animals; Calmodulin; Chlorocebus aethiops; COS Cells; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Mitogen-Activated Protein Kinases; Phenylalanine; Protein Kinase C; Quinazolines; ras Proteins; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thiophenes; Transcriptional Activation; Tyrphostins | 2002 |
Vitamin D inhibits the activation of stress-activated protein kinases by physiological and environmental stresses in keratinocytes.
Topics: Calcitriol; Cell Line; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Hot Temperature; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Mitogen-Activated Protein Kinases; Osmotic Pressure; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Quinazolines; Sorbitol; Time Factors; Tumor Necrosis Factor-alpha; Tyrphostins | 2002 |
Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.
Topics: Animals; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Serine Endopeptidases; Transfection; Tumor Cells, Cultured; Tyrphostins; Up-Regulation | 2002 |
EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.
Topics: Blotting, Northern; Carcinoma, Hepatocellular; Cell Division; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin beta1; Liver Neoplasms; Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinazolines; Receptors, Cell Surface; Receptors, Fibronectin; Receptors, Urokinase Plasminogen Activator; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2002 |
Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Division; Cell Line; Cell Size; Cell Transformation, Neoplastic; Dimerization; ErbB Receptors; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mutation; Neoplasm Invasiveness; Phosphorylation; Proteins; Quinazolines; Tyrphostins | 2002 |
Secretin regulates paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.
Topics: Animals; Cell Membrane Permeability; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Electric Impedance; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Gastric Mucosa; Mannitol; Parietal Cells, Gastric; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinazolines; Secretin; src-Family Kinases; Tyrphostins | 2002 |
Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretion.
Topics: Antibodies; Blotting, Western; Carbachol; Cell Line; Cell Membrane; Chlorides; Colon; Enzyme Inhibitors; ErbB Receptors; Humans; Immunosorbent Techniques; Interferon-gamma; Intestinal Mucosa; Kinetics; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; src-Family Kinases; Transforming Growth Factor alpha; Tyrphostins | 2002 |
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Calcium; Enzyme Inhibitors; Flavonoids; Hypertension; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tyrphostins | 2002 |
Lyn- and ERK-mediated vs. Ca2+ -mediated neutrophil O responses with thermal injury.
Topics: Animals; Burns; Calcium; Calcium Channel Blockers; Enzyme Activation; Enzyme Inhibitors; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Platelet Membrane Glycoproteins; Protein Kinase C; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cell Surface; Receptors, G-Protein-Coupled; src-Family Kinases; Tyrphostins | 2002 |
ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases.
Topics: Acetylcholine; Adenosine; Animals; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Female; Heart; In Vitro Techniques; Male; Myocardium; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins; Vasodilator Agents | 2002 |
Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases.
Topics: Animals; Antibodies, Monoclonal; Benzylamines; Calmodulin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Mitogen-Activated Protein Kinases; PC12 Cells; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Sulfonamides; Tyrphostins | 2002 |
Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; beta-Cyclodextrins; Blotting, Western; Cell Membrane; Cholesterol; COS Cells; Cross-Linking Reagents; Culture Media, Serum-Free; Cyclodextrins; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Immunoblotting; Isoenzymes; Ligands; Mass Spectrometry; Membrane Microdomains; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Proteins; Quinazolines; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Type C Phospholipases; Tyrosine; Tyrphostins | 2002 |
Angiotensin II triggers EGFR tyrosine kinase-dependent Ca2+ influx in afferent arterioles.
Topics: Angiotensin II; Animals; Arterioles; Calcium; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fluorescent Dyes; Fura-2; In Vitro Techniques; Intracellular Fluid; Kidney; Male; Manganese; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins | 2002 |
Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.
Topics: Androgen Antagonists; Cell Division; Cyclin D1; Enzyme Activation; ErbB Receptors; Flutamide; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Receptors, Androgen; Substance Withdrawal Syndrome; Tyrphostins | 2002 |
Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Movement; DNA, Neoplasm; Enzyme Inhibitors; ErbB Receptors; GTP-Binding Proteins; Head and Neck Neoplasms; Humans; Lysophospholipids; MAP Kinase Signaling System; Metalloendopeptidases; Phosphorylation; Quinazolines; Receptor, ErbB-2; S Phase; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrphostins | 2002 |
Relationship of EGFR signal-transduction modulation by tyrosine kinase inhibitors to chemosensitivity and programmed cell death in lung cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Lung Neoplasms; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2003 |
Proximal events in signaling by plasma membrane estrogen receptors.
Topics: Animals; Breast Neoplasms; Cattle; Cell Membrane; Cells, Cultured; Dipeptides; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Heterotrimeric GTP-Binding Proteins; Humans; Ligands; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinases; Models, Biological; Oligonucleotides, Antisense; Protease Inhibitors; Protein Binding; Protein Structure, Tertiary; Quinazolines; Receptors, Estrogen; Signal Transduction; Structure-Activity Relationship; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrphostins | 2003 |
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
Topics: Antineoplastic Agents; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Ionophores; Lung; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; Quinazolines; ras Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2002 |
4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway.
Topics: Acetylcysteine; Aldehydes; Cell Line; Culture Media, Conditioned; ErbB Receptors; Fibroblasts; Fibronectins; Humans; Imidazoles; Lipid Peroxidation; Lung; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pyridines; Quinazolines; Signal Transduction; Tyrphostins | 2002 |
Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Epidermal growth factor.
Topics: Animals; Breast Neoplasms; Cell Line; Dogs; Endosomes; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Humans; Kidney; Membrane Proteins; Mice; Monensin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2002 |
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibrosis; Flavonoids; In Vitro Techniques; Luciferases; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Quinazolines; Tyrphostins; Vasoconstriction | 2003 |
Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells.
Topics: Animals; Anisomycin; Antibody Specificity; Cell Membrane; Cells, Cultured; Connexin 43; Cytoplasm; Diuretics, Osmotic; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Fluorescent Antibody Technique; Liver; Microscopy, Confocal; Osmotic Pressure; Phosphorylation; Protein Synthesis Inhibitors; Quinazolines; Rabbits; Rats; Sorbitol; Tyrphostins | 2003 |
Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb.
Topics: Base Sequence; Blotting, Western; Caco-2 Cells; DNA; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myb; Quinazolines; Signal Transduction; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type IIb; Symporters; Transcription, Genetic; Tyrphostins | 2003 |
Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells.
Topics: 3T3 Cells; Animals; Bombesin; Bradykinin; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Stress Fibers; Tyrosine; Tyrphostins; Vasoconstrictor Agents; Vasopressins | 2003 |
Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).
Topics: 8,11,14-Eicosatrienoic Acid; Allantois; Animals; Aryl Hydrocarbon Hydroxylases; Cell Division; Cell Line; Chick Embryo; Chorion; Cyclin D1; Cytochrome P-450 CYP2C9; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Humans; Neovascularization, Physiologic; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor Cross-Talk; Tyrphostins | 2003 |
Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.
Topics: Animals; Blotting, Western; Calcium; Carbachol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Eye Proteins; Lacrimal Apparatus; Male; Peroxidase; Phenylephrine; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrphostins | 2003 |
P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Cell Division; Cells, Cultured; DNA; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Quinazolines; Receptors, Platelet-Derived Growth Factor; Receptors, Purinergic P2; Tyrphostins | 2003 |
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
Topics: Adenocarcinoma; Autocrine Communication; Cobalt Radioisotopes; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Prostatic Neoplasms; Protein Biosynthesis; Proteins; Quinazolines; Tumor Cells, Cultured; Tyrphostins; X-ray Repair Cross Complementing Protein 1 | 2003 |
Activated epidermal growth factor receptor (ErbB1) protects the heart against stress-induced injury in mice.
Topics: Aggression; Animals; Behavior, Animal; Cold Temperature; Epidermal Growth Factor; ErbB Receptors; Heart; Male; Mice; Myocardium; Quinazolines; Restraint, Physical; Stress, Physiological; Tyrphostins | 2003 |
Epidermal growth factor as a biologic switch in hair growth cycle.
Topics: Animals; Cell Division; Dimerization; Epidermal Growth Factor; Hair; Hair Follicle; Heterozygote; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Phenotype; Phosphorylation; Precipitin Tests; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin Physiological Phenomena; Time Factors; Tyrphostins | 2003 |
Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
Topics: Animals; Cell Differentiation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dinoprost; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Lysophospholipids; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; Parathyroid Hormone; Phosphorylation; Protein Kinase C; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin; Signal Transduction; Transcriptional Activation; Tyrphostins | 2003 |
Inhibitors that target protein kinases for the treatment of ovarian carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Catechols; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Nitriles; Ovarian Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Time Factors; Tumor Cells, Cultured; Tyrphostins | 2003 |
Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells.
Topics: Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Carbachol; Cells, Cultured; Cholinergic Agonists; Conjunctiva; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Goblet Cells; Humans; Male; Middle Aged; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Piperidines; Quinazolines; Rats; Rats, Sprague-Dawley; Time Factors; Tyrphostins | 2003 |
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.
Topics: Antigens, CD; Apoptosis; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cytokine Receptor gp130; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Head and Neck Neoplasms; Humans; Interleukin-6; Membrane Glycoproteins; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrphostins | 2003 |
Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR.
Topics: Animals; Arachidonate 5-Lipoxygenase; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Division; Chemokines; Collagen; Cytokines; Enzyme Inhibitors; Eosinophils; ErbB Receptors; Leukotrienes; Lung; Male; Mice; Mice, Inbred Strains; Mucus; Muscle, Smooth; Ovalbumin; Protein-Tyrosine Kinases; Quinazolines; RNA, Messenger; Tyrphostins | 2003 |
Activation of ERK1/2 by platelet-activating factor receptor is independent of receptor internalisation and G-protein activation.
Topics: Animals; Arrestins; beta-Adrenergic Receptor Kinases; Blotting, Western; Cell Line; Chlorocebus aethiops; Clathrin-Coated Vesicles; Cloning, Molecular; COS Cells; Cyclic AMP-Dependent Protein Kinases; Dynamins; Endocytosis; ErbB Receptors; Humans; Isoproterenol; Leukotriene B4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Pertussis Toxin; Phosphorylation; Platelet Membrane Glycoproteins; Quinazolines; Receptors, G-Protein-Coupled; Signal Transduction; Sucrose; Transfection; Tyrphostins | 2003 |
Alpha-adrenergic stimulation of ERK phosphorylation in astrocytes is alpha(2)-specific and may be mediated by transactivation.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Astrocytes; Blotting, Western; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fibrinolytic Agents; Heparin; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Quinazolines; Time Factors; Transcriptional Activation; Tyrphostins | 2003 |
Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects.
Topics: Amino Acid Sequence; Animals; Cardiovascular Abnormalities; ErbB Receptors; Humans; Molecular Sequence Data; Pyrimidines; Pyrroles; Quinazolines; Rats; Tyrphostins; Zebrafish | 2003 |
Expression of ErbB receptors in ES cell-derived cardiomyocytes.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Division; Culture Media, Serum-Free; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Green Fluorescent Proteins; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Luminescent Proteins; Mice; Mice, Transgenic; Microscopy, Fluorescence; Myocardium; Neuregulin-1; Quinazolines; Receptor, ErbB-4; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stem Cells; Time Factors; Transcription Factors; Tyrphostins; Xenopus Proteins | 2003 |
EGFRvIII-mediated radioresistance through a strong cytoprotective response.
Topics: Animals; Apoptosis; CHO Cells; Cricetinae; Cytoprotection; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Radiation Tolerance; Tyrphostins | 2003 |
EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2.
Topics: Actins; Animals; Cell Adhesion; Cells, Cultured; COS Cells; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Guanosine Triphosphate; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-vav; Quinazolines; rac GTP-Binding Proteins; Tyrosine; Tyrphostins | 2003 |
Epidermal growth factor receptor regulates normal urothelial regeneration.
Topics: Amphiregulin; Antibodies, Blocking; Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Movement; Cells, Cultured; DNA Primers; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Quinazolines; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transforming Growth Factor alpha; Tyrphostins; Urothelium; Wound Healing | 2003 |
Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.
Topics: 3T3 Cells; Animals; Cell Communication; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Hepatocyte Growth Factor; Humans; Kidney; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins; Quinazolines; Receptor Cross-Talk; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrphostins | 2003 |
Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells.
Topics: Amphiregulin; Aprotinin; Dose-Response Relationship, Drug; EGF Family of Proteins; Epithelial Cells; ErbB Receptors; Gene Expression Regulation; Glycoconjugates; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Leupeptins; Mucin 5AC; Mucin-2; Mucins; Protease Inhibitors; Quinazolines; Receptor, PAR-2; Respiratory Mucosa; Respiratory System; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrphostins | 2004 |
Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway.
Topics: Animals; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Cycle Proteins; Cell Division; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Male; MAP Kinase Signaling System; Microscopy, Confocal; Muscle, Smooth, Vascular; Phenotype; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; S Phase; Time Factors; Tumor Suppressor Proteins; Tyrphostins | 2003 |
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.
Topics: Androstadienes; Animals; Blotting, Western; Catalysis; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Kinetics; Male; Mice; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Potassium; Precipitin Tests; Protein Precursors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Time Factors; Transcriptional Activation; Tyrphostins; Up-Regulation; Venoms; Wortmannin | 2003 |
Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.
Topics: Androstadienes; Animals; Carbachol; cdc42 GTP-Binding Protein; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Kinetics; Lysophospholipids; Maleimides; Mice; Models, Biological; Myelin Basic Protein; NIH 3T3 Cells; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Quinazolines; rac GTP-Binding Proteins; ras Proteins; Receptor, Muscarinic M2; Receptors, Cell Surface; rho GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrphostins; Wortmannin | 2003 |
Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells.
Topics: Acetylcholine; Animals; Atropine; Cell Division; CHO Cells; Cholinergic Agonists; Colonic Neoplasms; Cricetinae; Drug Interactions; Egtazic Acid; ErbB Receptors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Ribosomal Protein S6 Kinases, 90-kDa; Transcriptional Activation; Tyrphostins | 2003 |
Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.
Topics: Androstadienes; Blotting, Western; Cell Line; Chlorides; Chlorine; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; GTP-Binding Protein alpha Subunits, Gs; Humans; Ions; Isoquinolines; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Quinazolines; Sulfonamides; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin | 2004 |
Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Survival; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Glioma; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured; Tyrphostins | 2003 |
Expression of a naturally occurring constitutively active variant of the epidermal growth factor receptor in mouse fibroblasts increases motility.
Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Movement; Enzyme Inhibitors; ErbB Receptors; Fibroblasts; Glioblastoma; Mice; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor Protein-Tyrosine Kinases; Tumor Cells, Cultured; Type C Phospholipases; Tyrphostins | 2004 |
Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells.
Topics: Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Quinazolines; Repressor Proteins; RNA, Messenger; Skin Neoplasms; Telomerase; Transforming Growth Factor alpha; Tyrphostins | 2003 |
EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Female; Genes, src; Humans; Kinetics; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Peptide Fragments; Phosphorylation; Quinazolines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Transcriptional Activation; Tyrphostins; Urokinase-Type Plasminogen Activator | 2004 |
Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death.
Topics: Adenosine Triphosphate; Cell Death; Cell Hypoxia; DNA Replication; ErbB Receptors; Glioma; Glucose; Humans; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Signal Transduction; Tyrphostins | 2004 |
Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation.
Topics: Cell Division; Cell Line, Tumor; Colonic Neoplasms; ErbB Receptors; Humans; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, PAR-2; Transcriptional Activation; Trypsin; Tyrphostins | 2004 |
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcholine; Angiotensin II; Animals; Antioxidants; Aorta; Bacterial Toxins; Cardiomyopathy, Hypertrophic; Cytochromes b; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Glycoproteins; Hypertension, Renovascular; Indoles; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Organ Culture Techniques; Polyethylene Glycols; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Superoxide Dismutase; Superoxides; Tyrphostins; Vasodilation; Vasodilator Agents | 2004 |
Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells.
Topics: Animals; Aorta; CHO Cells; Cricetinae; Cricetulus; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gi-Go; Lysophospholipids; MAP Kinase Signaling System; Membrane Lipids; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Sphingosine; Superoxides; Transcriptional Activation; Tyrphostins | 2004 |
Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.
Topics: Antibodies, Monoclonal; Cell Division; Cell Line, Tumor; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Inhibitory Concentration 50; Phosphorylation; Quinazolines; Receptor, ErbB-2; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrphostins | 2004 |
Insulin reduces the requirement for EGFR transactivation in bombesin-induced DNA synthesis.
Topics: Animals; Bombesin; DNA; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Insulin; Mice; Protein Tyrosine Phosphatases; Quinazolines; Swiss 3T3 Cells; Thymidine; Transcriptional Activation; Tritium; Tyrphostins | 2004 |
Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Line, Transformed; Cisplatin; Enzyme Inhibitors; ErbB Receptors; Kidney Tubules, Proximal; Male; MAP Kinase Signaling System; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Quinazolines; src-Family Kinases; Tyrphostins | 2004 |
Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity.
Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gi-Go; Hong Kong; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-jun; Quinazolines; Receptors, G-Protein-Coupled; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; src-Family Kinases; Type C Phospholipases; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growth.
Topics: Adult; Apoptosis; Cell Cycle; Cell Division; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Estradiol; Female; Humans; Leiomyoma; Myometrium; Phosphorylation; Progesterone; Protein-Tyrosine Kinases; Quinazolines; Tyrphostins; Uterine Neoplasms | 2004 |
The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells.
Topics: Binding Sites; Cell Line; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; ErbB Receptors; Factor VIIa; Focal Adhesion Kinase 2; Heparin-binding EGF-like Growth Factor; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Interleukin-8; Keratinocytes; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Recombinant Proteins; RNA, Messenger; Signal Transduction; Thromboplastin; Transcription Factors; Tyrphostins | 2004 |
[Effect of EGF on the intracellular distribution of heat-shock proteins in A431 cells].
Topics: Antibodies, Monoclonal; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Estrenes; Fluorescent Antibody Technique; Heat-Shock Proteins; Hot Temperature; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Phosphorylation; Protein-Tyrosine Kinases; Pyrrolidinones; Quinazolines; Time Factors; Type C Phospholipases; Tyrphostins; Vanadates | 2003 |
Activation of epidermal growth factor receptor via CCR3 in bronchial epithelial cells.
Topics: Bronchi; Cell Line; Chemokine CCL11; Chemokines, CC; Epithelial Cells; ErbB Receptors; Humans; Interleukin-8; Phosphorylation; Quinazolines; Receptor Cross-Talk; Receptors, CCR3; Receptors, Chemokine; Signal Transduction; Tyrosine; Tyrphostins | 2004 |
Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism.
Topics: Cell Line; Enzyme Inhibitors; ErbB Receptors; Humans; Phosphorylation; Quinazolines; Receptors, Calcium-Sensing; Signal Transduction; Transcriptional Activation; Tyrosine; Tyrphostins | 2004 |
Mechanisms of vascular angiotensin II surface receptor regulation by epidermal growth factor.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Cells, Cultured; Cytochalasin D; Dactinomycin; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Ligands; Muscle, Smooth, Vascular; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tyrphostins | 2004 |
Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells.
Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Heparin-binding EGF-like Growth Factor; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Mouth Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Receptor Cross-Talk; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrphostins | 2004 |
Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.
Topics: Animals; Cell Line; Chlorocebus aethiops; Endocytosis; ErbB Receptors; Humans; Insulin-Like Growth Factor I; Metalloendopeptidases; Mice; Mitogen-Activated Protein Kinase 3; Paracrine Communication; Phenylalanine; Phosphorylation; Quinazolines; Rats; Receptors, Somatomedin; Tetradecanoylphorbol Acetate; Thiophenes; Tyrosine; Tyrphostins | 2004 |
INK4a/Arf is required for suppression of EGFR/DeltaEGFR(2-7)-dependent ERK activation in mouse astrocytes and glioma.
Topics: Animals; Astrocytes; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Activation; ErbB Receptors; Glioma; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Tyrphostins | 2004 |
Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae.
Topics: Caveolin 1; Caveolins; Cell Division; Cell Line, Tumor; ErbB Receptors; Glioblastoma; Humans; Phosphorylation; Quinazolines; Tyrosine; Tyrphostins | 2004 |
Metalloprotease disintegrin-mediated ectodomain shedding of EGFR ligands promotes intestinal epithelial restitution.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Autocrine Communication; Blotting, Western; Cell Line; Culture Media, Conditioned; Epithelium; ErbB Receptors; Immunoprecipitation; Indicators and Reagents; Intestinal Mucosa; Ligands; Metalloendopeptidases; Metalloproteases; Neutralization Tests; Paracrine Communication; Protease Inhibitors; Quinazolines; Rats; Transforming Growth Factor alpha; Tyrphostins | 2004 |
Activation of epidermal growth factor receptors directs astrocytes to organize in a network surrounding axons in the developing rat optic nerve.
Topics: Animals; Animals, Newborn; Astrocytes; Axons; Culture Techniques; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Optic Nerve; Quinazolines; Rats; Rats, Wistar; Tyrphostins | 2004 |
L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer.
Topics: Acetaldehyde; Actins; Adherens Junctions; Caco-2 Cells; Cell Membrane Permeability; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Egtazic Acid; Endotoxins; ErbB Receptors; Glutamine; Humans; Lipopolysaccharides; Mannitol; Membrane Proteins; Occludin; Phosphorylation; Quinazolines; Tight Junctions; Tyrosine; Tyrphostins | 2004 |
Biglycan is internalized via a chlorpromazine-sensitive route.
Topics: Biglycan; Caveolae; Cells, Cultured; Chlorpromazine; Clathrin-Coated Vesicles; Decorin; Endocytosis; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Fibroblasts; Filipin; Humans; Phosphorylation; Proteoglycans; Quinazolines; Skin; Tyrphostins | 2004 |
Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.
Topics: Androgens; Animals; Autocrine Communication; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gene Expression Regulation; Isoquinolines; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinases; Phosphoproteins; Quinazolines; Rats; RNA, Messenger; Steroids; Sulfonamides; Transforming Growth Factor alpha; Tyrphostins | 2004 |
Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck.
Topics: Angiogenesis Inhibitors; Apoptosis; Carcinoma, Squamous Cell; Celecoxib; Cell Cycle; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Gefitinib; Head and Neck Neoplasms; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; Isoenzymes; Laryngeal Neoplasms; Lymphatic Metastasis; Membrane Proteins; Neovascularization, Pathologic; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Quinazolines; Sulfonamides; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrphostins | 2004 |
Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.
Topics: 3T3 Cells; Animals; Apoptosis; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Cytokines; DNA Replication; Enzyme Inhibitors; ErbB Receptors; Genes, erbB-1; Hematopoietic Stem Cells; Humans; MAP Kinase Signaling System; Mice; Quinazolines; Receptor, ErbB-2; Tyrphostins | 2004 |
Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells.
Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Butadienes; Cells, Cultured; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Mice; Microscopy, Confocal; Microtubule Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Nitriles; Phosphoproteins; Phosphorylation; PrPC Proteins; Quinazolines; RNA, Small Interfering; Stathmin; Tyrphostins | 2004 |
Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anthracenes; Aorta, Thoracic; Bacterial Proteins; Benzopyrans; Butadienes; Catheterization; Cell Division; Dipeptides; ErbB Receptors; Flavonoids; Glycine; Hydroxamic Acids; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Organ Culture Techniques; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Thrombin; Tyrphostins | 2004 |
Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.
Topics: Angiotensin II; Animals; Butadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Immunoblotting; Losartan; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tyrphostins | 2004 |
Entry of herpes simplex virus mediated by chimeric forms of nectin1 retargeted to endosomes or to lipid rafts occurs through acidic endosomes.
Topics: Ammonium Chloride; Androstadienes; Animals; Cell Adhesion Molecules; Cricetinae; Endocytosis; Endosomes; ErbB Receptors; Macrolides; Membrane Fusion; Membrane Microdomains; Nectins; Quinazolines; Receptors, Virus; Simplexvirus; Tyrphostins; Wortmannin | 2004 |
Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells.
Topics: Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cholangiocarcinoma; Cyclooxygenase 2; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Membrane Proteins; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Quinazolines; Signal Transduction; Tyrphostins; Ubiquitin | 2004 |
Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.
Topics: Androstadienes; Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Line; Cell Membrane; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermis; Epithelial Cells; ErbB Receptors; Genes, Dominant; Humans; Immunoblotting; Microscopy, Confocal; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, Angiotensin, Type 1; Signal Transduction; Threonine; Time Factors; Tyrphostins; Wortmannin | 2005 |
Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts.
Topics: Animals; ErbB Receptors; Fibroblasts; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Quinazolines; Rats; Receptor, Insulin; Signal Transduction; src-Family Kinases; Tyrphostins | 2005 |
Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent.
Topics: Animals; Aorta; Cell Movement; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Gene Expression; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyrimidines; Quinazolines; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins | 2005 |
Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers.
Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Models, Animal; Quinazolines; Radiation Injuries, Experimental; Radiation-Protective Agents; Radiation-Sensitizing Agents; Survival Analysis; Tyrphostins; Zebrafish | 2005 |
Growth of intestinal epithelium in organ culture is dependent on EGF signalling.
Topics: Animals; Apoptosis; Body Patterning; Cell Proliferation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Female; Intestines; Mice; Mice, Inbred ICR; Organ Culture Techniques; Pregnancy; Quinazolines; Signal Transduction; Tyrphostins | 2005 |
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.
Topics: Actin Depolymerizing Factors; Actin-Related Protein 2; Actin-Related Protein 3; Actins; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Cytoskeletal Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Fibronectins; GRB2 Adaptor Protein; Microfilament Proteins; Microscopy, Fluorescence; Models, Biological; Neoplasm Invasiveness; Nerve Tissue Proteins; Oncogene Proteins; Quinazolines; Rats; RNA, Small Interfering; Transfection; Tyrphostins; Wiskott-Aldrich Syndrome Protein Family; Wiskott-Aldrich Syndrome Protein, Neuronal | 2005 |
The effects of S-phase kinase-associated protein 2 (SKP2) on cell cycle status, viability, and chemoresistance in A549 lung adenocarcinoma cells.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Quinazolines; S-Phase Kinase-Associated Proteins; Tyrphostins | 2004 |
Activated EGFR promotes the survival of B-lineage acute leukemia in the absence of stromal cells.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Burkitt Lymphoma; Cell Cycle; Cell Line, Tumor; Cell Separation; Cell Survival; Cells, Cultured; Coculture Techniques; ErbB Receptors; Flow Cytometry; Humans; MAP Kinase Kinase Kinases; Phosphatidylinositol 3-Kinases; Quinazolines; Retroviridae; Stromal Cells; Time Factors; Tumor Cells, Cultured; Tyrphostins | 2005 |
[Effect of tyrosine kinase inhibitors on airway remodeling in bronchial asthma].
Topics: Animals; Asthma; Cells, Cultured; ErbB Receptors; Genistein; Male; Protein-Tyrosine Kinases; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Trachea; Tyrphostins | 2005 |
Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner.
Topics: Amphiregulin; Autocrine Communication; Bronchi; Cells, Cultured; Compressive Strength; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gene Expression Regulation; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Quinazolines; Respiratory Mucosa; Signal Transduction; Stress, Mechanical; Time Factors; Tyrphostins | 2005 |
Amphiregulin acts as an autocrine survival factor for adult sensory neurons.
Topics: Amphiregulin; Animals; Axons; Cell Survival; Cells, Cultured; Culture Techniques; Dose-Response Relationship, Drug; Drug Interactions; EGF Family of Proteins; Enzyme Inhibitors; ErbB Receptors; Female; Ganglia, Spinal; Glycoproteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Mice; Neurons, Afferent; Quinazolines; Tyrphostins | 2005 |
Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.
Topics: Alkaloids; Benzophenanthridines; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Morpholines; Phenanthridines; Protein Kinase C; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2005 |
The role of tyrosine kinase-mediated pathways in diabetes-induced alterations in responsiveness of rat carotid artery.
Topics: Animals; Benzothiazoles; Body Weight; Carotid Arteries; Diabetes Mellitus, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Genes, erbB-1; Genes, erbB-2; Genistein; In Vitro Techniques; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tyrphostins; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Induction; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor, Endothelin A; Signal Transduction; Transcriptional Activation; Tyrphostins | 2004 |
EGF receptor transactivation in angiotensin II and endothelin control of vascular protein synthesis in vivo.
Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Endothelins; ErbB Receptors; Heart Rate; Hypertension; Infusion Pumps, Implantable; Mesenteric Arteries; Protein Biosynthesis; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrphostins | 2004 |
Epidermal growth factor receptor tyrosine kinase-mediated signalling contributes to diabetes-induced vascular dysfunction in the mesenteric bed.
Topics: Angiotensin II; Animals; Carbachol; Cell Line; Diabetes Mellitus, Experimental; Endothelin-1; ErbB Receptors; Female; Genistein; Histamine; Humans; In Vitro Techniques; Mesenteric Arteries; Mesenteric Veins; Norepinephrine; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Streptozocin; Tyrphostins; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2005 |
Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases.
Topics: Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Genetic Vectors; Humans; Indole Alkaloids; Microscopy, Confocal; Neuroblastoma; Piperazines; Platelet-Derived Growth Factor; Quinazolines; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Dopamine D2; Simplexvirus; Spiperone; Transcriptional Activation; Transfection; Tritium; Tyrphostins | 2005 |
EGF-induced EGF-receptor and MAP kinase phosphorylation in goat cumulus cells during in vitro maturation.
Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Goats; Immunoassay; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Ovarian Follicle; Phosphorylation; Quinazolines; Time Factors; Tyrphostins | 2005 |
Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.
Topics: Apoptosis; Cell Cycle Proteins; Cell Growth Processes; Cell Line, Tumor; Down-Regulation; Dual Specificity Phosphatase 1; Enzyme Inhibitors; ErbB Receptors; Humans; Immediate-Early Proteins; Lung Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Quinazolines; Receptor, Notch3; Receptors, Cell Surface; Receptors, Notch; Transfection; Tyrphostins | 2005 |
Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor.
Topics: Animals; Anticarcinogenic Agents; Cell Proliferation; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Hyperplasia; MAP Kinase Signaling System; Mice; Mice, Nude; Neoplasms, Radiation-Induced; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Skin; Skin Neoplasms; Tyrphostins; Ultraviolet Rays | 2005 |
Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromones; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Trastuzumab; Tumor Cells, Cultured; Tyrphostins | 2005 |
Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology.
Topics: Blotting, Western; Carcinoma, Squamous Cell; Cell Communication; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Head and Neck Neoplasms; Humans; Neoplasm Proteins; Quinazolines; Signal Transduction; Tyrphostins | 2005 |
Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin.
Topics: Protein Binding; Quinazolines; Serum Albumin; Spectrometry, Fluorescence; Tyrphostins; Ultracentrifugation | 2005 |
Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2.
Topics: Animals; Astrocytes; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Nitrobenzenes; Optic Nerve; Optic Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Wistar; Sulfonamides; Tyrphostins | 2005 |
Studies of tyrosine phosphorylation and Src family tyrosine kinases in the lens epithelium.
Topics: Animals; Blotting, Western; Cell Proliferation; Enzyme Inhibitors; Epithelium; Lens, Crystalline; Organ Culture Techniques; Phosphorylation; Phosphotyrosine; Proliferating Cell Nuclear Antigen; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; src-Family Kinases; Swine; Tyrosine; Tyrphostins | 2005 |
Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRs.
Topics: Androstadienes; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 2; Gonadotropin-Releasing Hormone; Hepatocytes; Humans; Kidney; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphatidylinositol 3-Kinases; Protein Kinase C; Quinazolines; ras Proteins; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Tyrphostins; Wortmannin | 2006 |
A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes.
Topics: Animals; Antibodies, Monoclonal; Chlorocebus aethiops; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescence Recovery After Photobleaching; Fluorescence Resonance Energy Transfer; HeLa Cells; Humans; Immunoblotting; Kinetics; Microscopy, Video; Molecular Probes; Phosphorylation; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Quinazolines; Tyrosine; Tyrphostins | 2005 |
Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.
Topics: Animals; Arginase; Cattle; Cells, Cultured; Cytokines; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Genistein; Growth Inhibitors; Humans; Isoenzymes; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pulmonary Artery; Quinazolines; Tumor Necrosis Factor-alpha; Tyrphostins; Urea | 2005 |
Synergy of epidermal growth factor receptor kinase inhibitor AG1478 and ErbB2 kinase inhibitor AG879 in human colon carcinoma cells is associated with induction of apoptosis.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Humans; Phosphorylation; Quinazolines; Receptor, ErbB-2; Tyrphostins | 2005 |
PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Oxytocics; Phosphorylation; Quinazolines; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Transcriptional Activation; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Vascular Endothelial Growth Factor A | 2005 |
Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Genistein; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Urokinase-Type Plasminogen Activator | 2005 |
Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
Topics: Acetophenones; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Intracellular Signaling Peptides and Proteins; Oligonucleotides, Antisense; Phosphorylation; Protein Kinase C-delta; Pyrimidines; Quinazolines; Receptors, Neurokinin-1; RNA, Small Interfering; Signal Transduction; Tyrphostins | 2005 |
beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
Topics: Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epitopes; ErbB Receptors; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Lysophospholipids; Mice; Mice, Knockout; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphorylation; Quinazolines; ras Proteins; RNA; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrphostins | 2005 |
Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension.
Topics: Animals; Apoptosis; Enzyme Inhibitors; ErbB Receptors; Hypertension, Pulmonary; Integrin alphaVbeta3; Male; Metalloproteases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organ Culture Techniques; Protease Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins | 2005 |
Correlation of translocation of tight junction protein Zonula occludens-1 and activation of epidermal growth factor receptor in the regulation of invasion of pancreatic cancer cells.
Topics: Animals; BALB 3T3 Cells; Cell Line, Tumor; Cell Movement; Culture Media, Conditioned; Enzyme Inhibitors; ErbB Receptors; Humans; Membrane Proteins; Mice; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; Tight Junctions; Tyrphostins; Zonula Occludens-1 Protein | 2005 |
Air pollution particles activate NF-kappaB on contact with airway epithelial cell surfaces.
Topics: Air Pollutants; Animals; Binding, Competitive; Biological Transport; Deferoxamine; Dust; Epithelial Cells; Ferric Compounds; Free Radical Scavengers; In Vitro Techniques; NF-kappa B; Particle Size; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiourea; Time Factors; Titanium; Trachea; Tyrphostins | 2005 |
PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis.
Topics: Animals; Apoptosis; Cell Adhesion; Cell Survival; Cells, Cultured; Epithelial Cells; ErbB Receptors; Female; Flavonoids; Insulin; Laminin; Mammary Glands, Animal; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Tyrphostins; Vanadates | 2005 |
Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer.
Topics: Antibodies, Monoclonal; beta-Lactamases; Butadienes; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunohistochemistry; Inhibitory Concentration 50; MAP Kinase Kinase 1; Neoplasms; Nitriles; Oligonucleotides, Antisense; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transfection; Tyrphostins | 2005 |
Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Lewis Blood Group Antigens; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pentetic Acid; Protein-Tyrosine Kinases; Quinazolines; Radioimmunotherapy; Radiopharmaceuticals; Signal Transduction; Time Factors; Tissue Distribution; Tyrphostins; Yttrium Radioisotopes | 2005 |
EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans.
Topics: Animals; Axons; Calcium; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; GPI-Linked Proteins; Humans; Mice; Myelin Proteins; Nerve Crush; Nerve Regeneration; Neurites; Nogo Proteins; Nogo Receptor 1; Optic Nerve; Optic Nerve Injuries; Phosphorylation; Quinazolines; Receptors, Cell Surface; Retinal Ganglion Cells; Signal Transduction; Tyrphostins | 2005 |
Tyrphostin-A47 inhibitable tyrosine phosphorylation of flagellar proteins is associated with distinct alteration of motility pattern in hamster spermatozoa.
Topics: Animals; Cells, Cultured; Computer Simulation; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flagella; Male; Phosphorylation; Quinazolines; Sperm Motility; Spermatozoa; Time Factors; Tyrosine; Tyrphostins | 2006 |
Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells.
Topics: Cell Line, Tumor; Dipeptides; ErbB Receptors; Humans; Janus Kinase 2; Leptin; MAP Kinase Signaling System; Metalloproteases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protease Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinazolines; Receptors, Cell Surface; Receptors, Leptin; Recombinant Proteins; Stomach Neoplasms; Transcriptional Activation; Tyrphostins | 2005 |
Helicobacter pylori-stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase (ADAM) activation.
Topics: ADAM Proteins; Cell Line, Tumor; Cell Proliferation; DNA; Enzyme Activation; ErbB Receptors; Flavonoids; Glycine; Helicobacter pylori; Humans; Hydroxamic Acids; Interleukin-8; MAP Kinase Kinase 1; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Transcriptional Activation; Tyrphostins | 2005 |
Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor.
Topics: Cell Line, Tumor; Chemotaxis; Colonic Neoplasms; Dipeptides; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Humans; Interleukin-8; Lysophospholipids; Phosphorylation; Phosphotyrosine; Protease Inhibitors; Quinazolines; Transcriptional Activation; Tyrphostins | 2006 |
Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway.
Topics: Adenocarcinoma; Adult; Aged; Blotting, Western; Butadienes; Culture Media, Conditioned; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Male; Matrix Metalloproteinase 7; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Nitriles; Pancreatic Neoplasms; Quinazolines; Signal Transduction; Tight Junctions; Tumor Cells, Cultured; Tyrphostins | 2005 |
EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells.
Topics: Animals; Apoptosis; Butadienes; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hydrogen Peroxide; Kidney Tubules, Proximal; MAP Kinase Kinase 1; Membrane Potentials; Mitochondrial Membranes; Nitriles; Opossums; Oxidants; Pyrimidines; Quinazolines; Transfection; Tyrphostins | 2006 |
Direct involvement of G protein alpha(q/11) subunit in regulation of muscarinic receptor-mediated sAPPalpha release.
Topics: Amino Acid Sequence; Cell Line, Tumor; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Molecular Sequence Data; Muscarinic Agonists; Quinazolines; Receptor Cross-Talk; Receptor, Muscarinic M3; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Serum Amyloid A Protein; Transfection; Tyrphostins | 2005 |
Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.
Topics: Actin Depolymerizing Factors; Actomyosin; Adenomatous Polyposis Coli Protein; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Cadherins; Calcium; Cardiac Myosins; Celecoxib; Cell Adhesion; Egtazic Acid; Enterocytes; ErbB Receptors; Focal Adhesion Kinase 2; GTP-Binding Protein alpha Subunits, G12-G13; Intestinal Mucosa; Intestine, Small; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase 1; Muscle Contraction; Muscle Relaxants, Central; Myosin Light Chains; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Quinazolines; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Sulfonamides; Tyrphostins; Up-Regulation | 2006 |
Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation.
Topics: Animals; Antigen Presentation; Antigens, Surface; Apoptosis; Aspirin; Cell Line, Tumor; Cell Membrane; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fas Ligand Protein; Female; Flavonoids; Humans; Lymphocyte Activation; Lymphocytes; Lysophospholipids; Membrane Glycoproteins; Nitrobenzenes; Ovarian Neoplasms; Quinazolines; Signal Transduction; Sulfonamides; Tumor Necrosis Factors; Tyrphostins | 2006 |
Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis.
Topics: Animals; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; ErbB Receptors; Humans; Lapatinib; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Tyrphostins; Xenograft Model Antitumor Assays | 2006 |
Inhibition of autophosphorylation of epidermal growth factor receptor by small peptides in vitro.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Binding Sites; Blotting, Western; Drug Interactions; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; In Vitro Techniques; Molecular Sequence Data; Oligopeptides; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptor, Insulin; Tyrphostins | 2006 |
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
Topics: Androstadienes; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Infrared Rays; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; Radiation, Ionizing; Signal Transduction; src-Family Kinases; Temperature; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Wortmannin; X-Rays | 2006 |
Vascular responses to alpha1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Dipeptides; Doxycycline; ErbB Receptors; In Vitro Techniques; Matrix Metalloproteinase 7; Mesenteric Arteries; Mitochondria, Muscle; Phenylephrine; Quinazolines; Rats; Reactive Oxygen Species; Receptors, Adrenergic, alpha-1; Signal Transduction; Tyrphostins; Vasoconstriction; Vasoconstrictor Agents | 2006 |
Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292.
Topics: Amphiregulin; Antibodies, Blocking; Cell Line; Dipeptides; EGF Family of Proteins; Epithelial Cells; ErbB Receptors; Glycoproteins; Humans; Hydroxamic Acids; Immunoblotting; Intercellular Signaling Peptides and Proteins; Interleukin-8; Kinetics; Metalloproteases; Protease Inhibitors; Quinazolines; Transcriptional Activation; Tumor Necrosis Factor-alpha; Tyrphostins | 2006 |
Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells.
Topics: Carcinoma, Mucoepidermoid; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Humans; Hypoglycemic Agents; Lung Neoplasms; Mucin 5AC; Mucins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; PPAR gamma; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Respiratory Mucosa; Rosiglitazone; Smoking; Thiazolidinediones; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2006 |
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Proliferation; Chromatin Immunoprecipitation; Chromones; Dermis; DNA; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression; Gene Expression Regulation; Hair Diseases; Integrases; Keratinocytes; Keratins; Ki-67 Antigen; MAP Kinase Signaling System; Mice; Mice, Transgenic; Morpholines; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Skin; Skin Abnormalities; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transforming Growth Factor alpha; Tyrphostins | 2006 |
TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling.
Topics: Animals; Cell Line; E-Box Elements; Enzyme Inhibitors; ErbB Receptors; Humans; MAP Kinase Kinase Kinases; Mutagenesis, Site-Directed; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins | 2006 |
Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gq-G11; Heart Ventricles; Hypertrophy; Myocardium; Myocytes, Cardiac; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Transcriptional Activation; Tyrphostins | 2006 |
The invasive behaviour of prostatic cancer cells is suppressed by inhibitors of tyrosine kinase.
Topics: Basement Membrane; Biological Assay; Carcinoma; Cell Movement; Collagen; Drug Combinations; Genistein; Humans; Laminin; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Neoplasm Invasiveness; Plasminogen; Plasminogen Activators; Prostatic Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteoglycans; Quinazolines; Tyrphostins | 2006 |
A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling.
Topics: Breast Neoplasms; Cell Line, Tumor; ErbB Receptors; Eukaryotic Initiation Factor-4E; Humans; Integrin alpha6beta4; Neoplasm Invasiveness; Phosphorylation; Protein Biosynthesis; Quinazolines; ras Proteins; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction; Transcriptional Activation; Transfection; Tyrphostins | 2006 |
Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.
Topics: Animals; Area Under Curve; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Injections, Intravenous; Injections, Subcutaneous; Mice; Molecular Structure; Protein Tyrosine Phosphatases; Quinazolines; Rats; Thymidine; Tyrphostins; Xenograft Model Antitumor Assays | 2006 |
PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.
Topics: Cell Line, Tumor; Cell Movement; Dipeptides; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Kidney Neoplasms; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Oligopeptides; Phosphorylation; Pyrroles; Quinazolines; Receptor, PAR-1; Thrombin; Tyrosine; Tyrphostins | 2006 |
Inhibition of epidermal growth factor receptor activation enhances in vivo histamine-stimulated gastric acid secretion in the rat.
Topics: Animals; ErbB Receptors; Gastric Acid; Histamine; Histamine H2 Antagonists; Male; Phosphorylation; Quinazolines; Ranitidine; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha; Tyrphostins | 2006 |
Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells (RPTEC).
Topics: Aldosterone; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Humans; Kidney Tubules, Proximal; Quinazolines; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Tyrphostins | 2006 |
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.
Topics: Adult; Benzo(a)pyrene; Calcium; Calcium Signaling; Carcinogens, Environmental; Cells, Cultured; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Female; Genistein; Humans; Myometrium; Oxytocin; Pregnancy; Protein-Tyrosine Kinases; Quinazolines; Tetraethylammonium; Tyrphostins | 2006 |
Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor.
Topics: Angiotensin II; Animals; Arachidonic Acid; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Glutathione Transferase; Kidney Tubules, Proximal; Kinetics; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Quinazolines; Rabbits; Recombinant Fusion Proteins; Transcriptional Activation; Tyrphostins | 2006 |
Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).
Topics: Animals; Cell Line; Chorionic Gonadotropin; Enzyme Activation; Genes, Dominant; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein-Tyrosine Kinases; Quinazolines; ras GTPase-Activating Proteins; ras Proteins; Receptors, LH; Tyrphostins | 2006 |
Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK.
Topics: Animals; Apoptosis; Cell Differentiation; Culture Media, Serum-Free; ErbB Receptors; Grifola; GTP-Binding Protein alpha Subunits, Gi-Go; Lysophospholipids; MAP Kinase Signaling System; Nerve Growth Factors; Neurites; Neurons; Neuroprotective Agents; PC12 Cells; Quinazolines; Rats; Tyrphostins | 2006 |
HER2 expression as a potential marker for response to therapy targeted to the EGFR.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Laser Scanning Cytometry; Mitogen-Activated Protein Kinases; Phosphorylation; Predictive Value of Tests; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Sensitivity and Specificity; Structure-Activity Relationship; Trastuzumab; Tyrphostins | 2006 |
Tyrosine kinase inhibitors alter adhesivity of prostatic cancer cells to extracellular matrix components.
Topics: Cell Adhesion; Cell Line, Tumor; Cell Survival; Extracellular Matrix; Genistein; Humans; Integrins; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2006 |
Urokinase plasminogen activator receptor (uPAR) expression is reduced by tyrosine kinase inhibitors.
Topics: Adenocarcinoma; Cell Line, Tumor; Gene Expression; Genistein; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Tyrphostins | 2006 |
EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; CHO Cells; Cricetinae; Down-Regulation; ErbB Receptors; Humans; Mice; NIH 3T3 Cells; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-cbl; Quinazolines; Transfection; Tyrphostins; Ubiquitin | 2006 |
Transcription levels of invasion-related genes in prostate cancer cells are modified by inhibitors of tyrosine kinase.
Topics: Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genistein; Humans; Male; Metalloproteases; Prostatic Neoplasms; Protein Array Analysis; Protein-Tyrosine Kinases; Quinazolines; RNA, Messenger; Transcription, Genetic; Tyrphostins; Urokinase-Type Plasminogen Activator | 2006 |
Gefitinib prevents bleomycin-induced lung fibrosis in mice.
Topics: Animals; Bleomycin; Cell Culture Techniques; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Fibroblasts; Gefitinib; Humans; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Pulmonary Fibrosis; Quinazolines; Tyrphostins | 2006 |
Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells.
Topics: Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Leuprolide; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Time Factors; Tyrphostins | 2006 |
STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.
Topics: Animals; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Hydrogen Peroxide; Janus Kinase 2; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred Strains; Oxidative Stress; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Tyrosine; Tyrphostins | 2006 |
Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Antibodies; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Endothelin-1; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Norepinephrine; Phenylalanine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Thiophenes; Tyrphostins; Wortmannin | 2006 |
[Involvement of epidermal growth factor receptor signaling pathway in tamoxifen resistance of MCF-7 cells].
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Quinazolines; Receptors, Estrogen; RNA, Messenger; Signal Transduction; Tamoxifen; Tyrphostins | 2006 |
GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.
Topics: Animals; Cell Adhesion Molecules; Cyclooxygenase 2; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Female; Glucuronosyltransferase; Gonadotropin-Releasing Hormone; Hyaluronan Synthases; Meiosis; Ovarian Follicle; Ovulation; Phosphorylation; Progesterone; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Tyrphostins | 2006 |
[Oxidized glutathione induces activation of the epidermal growth factor receptor and MAP kinases ERK 1,2].
Topics: Animals; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Glutathione Disulfide; Humans; Mice; Mitogen-Activated Protein Kinase 1; NIH 3T3 Cells; Oligopeptides; Quinazolines; Transcriptional Activation; Tyrphostins | 2006 |
Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Survival; Cetuximab; Cisplatin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Head and Neck Neoplasms; Humans; Phosphorylation; Quinazolines; Tyrosine; Tyrphostins | 2006 |
Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells.
Topics: Animals; Cell Line; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Focal Adhesion Kinase 2; Hydrogen Peroxide; Immunoblotting; Insulin-Like Growth Factor I; Models, Biological; Muscle, Smooth, Vascular; Oxidants; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Receptor, IGF Type 1; src-Family Kinases; Tyrosine; Tyrphostins | 2006 |
EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.
Topics: Actins; Animals; Antioxidants; Chromones; Endothelial Cells; Epithelial Cells; ErbB Receptors; Gene Expression Regulation; Lung; Mice; Morpholines; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Response Elements; RNA, Messenger; Signal Transduction; Stress, Mechanical; Transcription, Genetic; Tyrphostins | 2007 |
Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.
Topics: 3T3-L1 Cells; Adipocytes; Adrenergic beta-3 Receptor Agonists; Animals; Cyclic AMP-Dependent Protein Kinases; Dioxoles; Enzyme Activation; ErbB Receptors; Estradiol; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Isoquinolines; Lipolysis; Mice; Quinazolines; Receptors, Adrenergic, beta-3; RNA, Small Interfering; src-Family Kinases; Sulfonamides; Tyrphostins | 2006 |
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.
Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line, Tumor; Dimerization; ErbB Receptors; Flow Cytometry; Humans; Kinetics; Mice; Mice, Nude; Protein-Tyrosine Kinases; Quinazolines; Transplantation, Heterologous; Tyrphostins | 2007 |
Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells.
Topics: Animals; Cell Line; Cells, Cultured; Culture Media, Conditioned; Dipeptides; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Distal; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Parathyroid Hormone; Peptide Fragments; Pertussis Toxin; Phosphoproteins; Phosphorylation; Quinazolines; Receptor, Parathyroid Hormone, Type 1; Receptors, Cell Surface; Sodium-Hydrogen Exchangers; Transfection; Tyrphostins | 2007 |
Signaling of mitochondrial biogenesis following oxidant injury.
Topics: Animals; Cells, Cultured; ErbB Receptors; Female; Kidney Tubules, Proximal; Mitochondria; Oxidants; Oxidative Stress; Quinazolines; Rabbits; Regeneration; Reperfusion Injury; Signal Transduction; tert-Butylhydroperoxide; Transcription Factors; Tyrphostins | 2007 |
Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence.
Topics: Animals; Apoptosis; Benzothiazoles; Cell Survival; Humans; Ligands; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Muscle Cells; Protein Kinase Inhibitors; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Satellite Cells, Skeletal Muscle; Signal Transduction; Stem Cells; Tyrphostins | 2007 |
Transactivation of EGFR mediates insulin-stimulated ERK1/2 activation and enhanced cell migration in human corneal epithelial cells.
Topics: Cell Line, Transformed; Cell Movement; Cytoskeleton; Dipeptides; Enzyme Activation; Epithelium, Corneal; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Insulin; Isoenzymes; Metalloendopeptidases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protease Inhibitors; Quinazolines; Transcriptional Activation; Tyrphostins; Wound Healing | 2006 |
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
Topics: Adenocarcinoma, Follicular; Aprotinin; Blotting, Western; Carcinoma, Papillary; Cell Differentiation; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Protease Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Serine Proteinase Inhibitors; Tetracyclines; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrphostins | 2006 |
Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; CpG Islands; DNA Methylation; Enzyme Inhibitors; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Quinazolines; Receptors, Retinoic Acid; RNA Processing, Post-Transcriptional; Transcription, Genetic; Tyrphostins; Up-Regulation | 2007 |
Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells.
Topics: Animals; Blotting, Western; Butadienes; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Hexamethonium; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitriles; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tyrphostins; Vascular Endothelial Growth Factor A | 2007 |
Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation.
Topics: Animals; Bacterial Proteins; Cell Proliferation; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Pulmonary Veins; Quinazolines; Sheep; Signal Transduction; Time Factors; Transfection; Tyrphostins | 2007 |
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Chromones; Enzyme Inhibitors; Gene Expression; Glioma; Gliosarcoma; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Morpholines; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Transfection; Tyrphostins | 2007 |
EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation.
Topics: Animals; beta Catenin; Cell Movement; Cell Proliferation; Cytoskeleton; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Intercellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; NIH 3T3 Cells; Quinazolines; raf Kinases; ras Proteins; RNA, Small Interfering; Tyrphostins; Wnt Proteins; Wnt3 Protein; Wnt3A Protein | 2007 |
Epiregulin promotes proliferation and migration of renal proximal tubular cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rabbits; Tyrphostins; Wound Healing | 2007 |
Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.
Topics: Antimony; Arsenites; beta Catenin; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Line, Transformed; Cell Proliferation; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Humans; Insulin; Keratinocytes; Male; Matrix Metalloproteinase 7; PPAR delta; Pyrimidines; Quinazolines; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tyrphostins | 2007 |
The control of tissue architecture over nuclear organization is crucial for epithelial cell fate.
Topics: Antigens, Neoplasm; Antigens, Nuclear; Apoptosis; beta Catenin; Cell Culture Techniques; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Polarity; Chromones; Collagen Type IV; Enzyme Inhibitors; Epigenesis, Genetic; Epithelial Cells; ErbB Receptors; Histones; Humans; Integrin alpha6; Ki-67 Antigen; Membrane Proteins; Morpholines; Mucin-1; Mucins; Neoplasm Proteins; Nuclear Matrix-Associated Proteins; Nuclear Proteins; Phosphoproteins; Promyelocytic Leukemia Protein; Quinazolines; RNA, Small Interfering; Transcription Factors; Tumor Suppressor Proteins; Tyrphostins; Zonula Occludens-1 Protein | 2007 |
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.
Topics: Acetophenones; Animals; Anthracenes; Benzamides; Chromones; Dioxoles; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heparin-binding EGF-like Growth Factor; Hepatocytes; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Morpholines; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Onium Compounds; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Transforming Growth Factor beta; Tyrphostins; Up-Regulation | 2007 |
Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Hepatocytes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Biological; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Sphingosine; Tyrphostins; Wortmannin | 2007 |
Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.
Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Dipeptides; Epidermal Growth Factor; Flavonoids; Immunohistochemistry; Inositol Phosphates; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyrazoles; Pyrimidines; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Steroids; Tyrphostins | 2007 |
Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway.
Topics: Adenocarcinoma; Cell Adhesion; Cell Hypoxia; Cell Line, Tumor; Cell Movement; ErbB Receptors; Humans; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Quinazolines; Signal Transduction; Tyrphostins | 2007 |
Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Bronchi; Bronchial Neoplasms; Carcinoma, Mucoepidermoid; Cell Line, Tumor; Chloride Channels; ErbB Receptors; Gene Expression; Humans; Male; Mucin 5AC; Mucins; Niflumic Acid; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smoking; Tyrphostins | 2007 |
Epidermal growth factor receptor is not required for human cytomegalovirus entry or signaling.
Topics: Cell Fusion; Cell Line; Cytomegalovirus; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Fibroblasts; Humans; Neutralization Tests; Quinazolines; Signal Transduction; Time Factors; Tyrphostins; Viral Proteins; Virus Internalization | 2007 |
ERK-dependent and -independent pathways trigger human neural progenitor cell migration.
Topics: Astrocytes; Blotting, Western; Cell Differentiation; Cell Movement; Cell Survival; Cells, Cultured; Flavonoids; Humans; Indoles; Maleimides; Methylmercury Compounds; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Protein Kinase C; Pyrimidines; Quinazolines; Signal Transduction; Spheroids, Cellular; src-Family Kinases; Stem Cells; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins | 2007 |
Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species.
Topics: Animals; Aorta; Cell Proliferation; Cells, Cultured; ErbB Receptors; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; src-Family Kinases; Transcriptional Activation; Tyrphostins | 2007 |
Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium.
Topics: Acetylcholine; Adult; Aged; Aged, 80 and over; Calcium; Calcium Signaling; Chloroquine; Cholinergic Agents; Colforsin; Colon; Cyclic AMP; ErbB Receptors; Humans; Intestinal Mucosa; Lysosomes; Middle Aged; Protein Synthesis Inhibitors; Quinazolines; Receptor, Muscarinic M3; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Tissue Distribution; Tyrphostins | 2007 |
Effect of combining epidermal growth factor receptor inhibitors and cisplatin on proliferation and apoptosis of oral squamous cell carcinoma cells.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cetuximab; Cisplatin; Enzyme Inhibitors; ErbB Receptors; Humans; Inhibitor of Apoptosis Proteins; Mouth Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins | 2007 |
The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Drug Interactions; Enzyme Inhibitors; ErbB Receptors; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neuregulin-1; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Quinazolines; Rats; Receptor, ErbB-4; RNA Interference; RNA, Small Interfering; Synapses; Synaptic Transmission; Transfection; Tyrphostins | 2007 |
Depolarization-induced, glutamate receptor-mediated, and transactivation-dependent extracellular-signal regulated kinase phosphorylation in cultured cerebellar granule neurons.
Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Dipeptides; Enzyme Inhibitors; ErbB Receptors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; Heparin Antagonists; Metalloproteases; Mice; Neurons; Phosphorylation; Potassium; Protease Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcriptional Activation; Tyrphostins | 2007 |
EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes.
Topics: Adenosine Monophosphate; Amphiregulin; Animals; Cells, Cultured; Cumulus Cells; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Glycoproteins; Intercellular Signaling Peptides and Proteins; Meiosis; Mice; Oocytes; Peptides; Protein Kinase C; Quinazolines; Tyrphostins | 2008 |
Heparin-binding EGF-like growth factor mediates oxyhemoglobin-induced suppression of voltage-dependent potassium channels in rabbit cerebral artery myocytes.
Topics: Animals; Cerebral Arteries; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Metalloproteases; Myocytes, Smooth Muscle; Oxyhemoglobins; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Protein Kinase C; Quinazolines; Rabbits; Tyrphostins | 2007 |
Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Dose-Response Relationship, Drug; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Ileum; Imidazoles; Mitochondria; Mitogen-Activated Protein Kinase 14; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinazolines; Rats; RNA Interference; RNA, Small Interfering; Signal Transduction; Time Factors; Tyrphostins | 2007 |
Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes.
Topics: Adenosine Triphosphate; Animals; Antibodies; Autocrine Communication; Benzothiazoles; Biological Transport; Cell Movement; Cell Proliferation; Cells, Cultured; Drug Synergism; Electric Conductivity; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; KCNQ1 Potassium Channel; Male; Pinacidil; Potassium; Potassium Channels; Protein Kinase Inhibitors; Pulmonary Alveoli; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Tyrphostins; Wound Healing | 2007 |
Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Cells, Cultured; Culture Media, Serum-Free; Cyclin D; Cyclins; Dinoprostone; DNA; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Gene Expression Regulation; Hepatocytes; Liver Neoplasms; Male; Pertussis Toxin; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tyrphostins | 2008 |
Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway.
Topics: Collagenases; Epithelial Cells; ErbB Receptors; Famotidine; Gene Expression Regulation, Enzymologic; Heparin-binding EGF-like Growth Factor; Histamine; Humans; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase Inhibitors; Quinazolines; RNA, Small Interfering; Stomach; Time Factors; Transcriptional Activation; Tyrphostins | 2007 |
Activation of MEK-ERK by heregulin-beta1 promotes the development of cardiomyocytes derived from ES cells.
Topics: Animals; Cell Differentiation; Embryonic Stem Cells; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Neuregulin-1; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Tyrphostins | 2007 |
Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.
Topics: Animals; Aorta, Thoracic; Blotting, Northern; Blotting, Western; Butadienes; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Endothelin-1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Leptin; Male; Metalloendopeptidases; Myocytes, Smooth Muscle; Nitriles; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Signal Transduction; Transcriptional Activation; Tyrosine; Tyrphostins | 2007 |
Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cetuximab; Enzyme Inhibitors; ErbB Receptors; fas Receptor; Fas-Associated Death Domain Protein; Humans; Mouth Neoplasms; Neoplasm Proteins; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-akt; Quinazolines; Tumor Cells, Cultured; Tyrphostins | 2008 |
Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility.
Topics: Ejaculation; Enzyme Inhibitors; ErbB Receptors; Humans; Male; Microscopy, Immunoelectron; Oligopeptides; Quinazolines; Receptor, PAR-2; Reference Values; Semen; Sperm Motility; Spermatozoa; Tyrphostins | 2007 |
EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
Topics: Animals; Apoptosis; Cell Survival; Cycloheximide; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibronectins; Integrin beta3; Intestinal Mucosa; MAP Kinase Kinase Kinases; Mice; Mutation; Oligopeptides; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphorylation; Polyamines; Protein Kinase Inhibitors; Putrescine; Pyrimidines; Quinazolines; Rats; Signal Transduction; src-Family Kinases; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2007 |
Thrombin increases hyposmotic taurine efflux and accelerates ICI-swell and RVD in 3T3 fibroblasts by a src-dependent EGFR transactivation.
Topics: Animals; Calcium; Cell Size; Chloride Channels; Chlorides; Egtazic Acid; Enzyme Inhibitors; ErbB Receptors; Estrenes; Hemostatics; Mice; Osmotic Pressure; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pyrimidines; Pyrrolidinones; Quinazolines; Signal Transduction; src-Family Kinases; Swiss 3T3 Cells; Taurine; Thrombin; Tritium; Tyrphostins | 2008 |
Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor.
Topics: ADAM Proteins; ADAM17 Protein; Amphiregulin; Animals; Blotting, Western; Cells, Cultured; Cumulus Cells; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Flavonoids; Follicle Stimulating Hormone; Gene Expression; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oocytes; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Swine; Transfection; Tyrphostins | 2007 |
Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion.
Topics: Biological Transport; Cell Line; Cell Membrane; Dipeptides; ErbB Receptors; Exocytosis; Humans; Intracellular Membranes; Metalloproteases; Phenylmercuric Acetate; Protein Isoforms; Protein Structure, Tertiary; Quinazolines; Signal Transduction; Tyrphostins | 2008 |
Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Kidney; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Inbred WKY; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Tyrphostins; Vasoconstrictor Agents | 2008 |
Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.
Topics: Animals; Antioxidants; Azoles; Butadienes; Carbazoles; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Indole Alkaloids; Isoindoles; Mitogen-Activated Protein Kinases; Neurites; Neurofilament Proteins; Nitriles; Organoselenium Compounds; Oxidation-Reduction; PC12 Cells; Pertussis Toxin; Phosphorylation; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Selenium; Tyrphostins | 2008 |
Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC.
Topics: Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Indoles; Lysophosphatidylcholines; Maleimides; MAP Kinase Signaling System; Mesangial Cells; Protein Kinase C; Quinazolines; src-Family Kinases; Tyrphostins | 2007 |
Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity.
Topics: Animals; Cell Movement; Epidermal Growth Factor; Ion Channel Gating; Male; Prostatic Neoplasms; Quinazolines; Rats; Sodium Channels; Tetrodotoxin; Tyrphostins; Up-Regulation | 2008 |
Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Angiotensin II; Animals; Cell Line; CHO Cells; Chromones; Cricetinae; Cricetulus; Gene Expression; Humans; Indoles; Maleimides; Membrane Glycoproteins; Morpholines; Mutation; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Kinase C; Pyrazoles; Pyrimidines; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Superoxides; Tyrphostins; Wortmannin | 2008 |
PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte.
Topics: Animals; Butadienes; Cells, Cultured; Chromones; Cumulus Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Meiosis; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Swine; Tyrphostins | 2008 |
Involvement of tyrosine kinase in the hyposmotic stimulation of I Ks in guinea-pig ventricular myocytes.
Topics: Action Potentials; Animals; Cell Size; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; ErbB Receptors; Genistein; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Kinetics; Myocytes, Cardiac; Osmotic Pressure; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Signal Transduction; src-Family Kinases; Tyrphostins; Vanadates | 2008 |
In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.
Topics: Amino Acid Transport System ASC; Androstadienes; Blotting, Western; Caco-2 Cells; Cell Membrane; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamine; Humans; Minor Histocompatibility Antigens; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; rho GTP-Binding Proteins; RNA Interference; Signal Transduction; Sodium; Time Factors; Tyrphostins; Up-Regulation; Wortmannin | 2008 |
Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells.
Topics: ADAM Proteins; Animals; Autocrine Communication; Bacterial Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Dipeptides; Epithelial Cells; ErbB Receptors; Female; Heparin-binding EGF-like Growth Factor; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Matrix Metalloproteinases; Oxidative Stress; Paracrine Communication; Phosphorylation; Quinazolines; Rabbits; RNA, Small Interfering; src-Family Kinases; Tyrphostins; Wound Healing | 2008 |
Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.
Topics: Androstadienes; Blotting, Western; Cell Adhesion; Cell Line; Chromones; Dose-Response Relationship, Drug; E1A-Associated p300 Protein; ErbB Receptors; Humans; Lipopolysaccharides; Morpholines; Myocytes, Smooth Muscle; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Trachea; Transfection; Tyrphostins; Vascular Cell Adhesion Molecule-1; Wortmannin | 2008 |
Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt.
Topics: Cell Proliferation; Chromones; Enzyme Activation; Fibroblasts; Gamma Rays; Humans; Lung; Morpholines; p21-Activated Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Quinazolines; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins | 2007 |
Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.
Topics: Amphiregulin; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipeptides; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Glycoproteins; Hydroxamic Acids; Immunohistochemistry; Immunoprecipitation; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Mice; Mitogen-Activated Protein Kinases; Oocytes; Ovarian Follicle; Phosphorylation; Protein Biosynthesis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrphostins | 2008 |
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle c
Topics: Active Transport, Cell Nucleus; Antibodies; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cell Adhesion; Cell Nucleus; Chromones; E1A-Associated p300 Protein; Enzyme Activation; Gene Expression Regulation; Histone Acetyltransferases; Histone Deacetylases; Humans; Isoenzymes; Morpholines; Myocytes, Smooth Muscle; Neutrophils; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Quinazolines; Repressor Proteins; Trachea; Tumor Necrosis Factor-alpha; Tyrphostins; Vascular Cell Adhesion Molecule-1 | 2008 |
TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.
Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; ErbB Receptors; Mice; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Smad Proteins; Smad2 Protein; Transforming Growth Factor beta1; Tyrphostins | 2008 |
TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Epithelium; ErbB Receptors; Female; Genes, erbB-2; Humans; Mesoderm; Neoplasm Proteins; Phenotype; Protein Kinase Inhibitors; Quinazolines; Receptors, Estrogen; Receptors, Progesterone; Receptors, TNF-Related Apoptosis-Inducing Ligand; Recombinant Fusion Proteins; RNA Interference; Tyrphostins | 2009 |
Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.
Topics: AC133 Antigen; Antigens, CD; Brain Neoplasms; Enzyme Inhibitors; Epidermal Growth Factor; Gefitinib; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Models, Biological; Peptides; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Stem Cells; Tumor Cells, Cultured; Tyrphostins | 2008 |
Differential sensitivity of A549 non-small lung carcinoma cell responses to epidermal growth factor receptor pathway inhibitors.
Topics: Antibodies, Blocking; Antineoplastic Agents; Biological Assay; Carcinoma, Non-Small-Cell Lung; Cell Movement; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lung Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2008 |
Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice.
Topics: Aminoquinolines; Aniline Compounds; Animals; Aortic Valve; Apoptosis; ErbB Receptors; Female; Heart; Heart Ventricles; Male; Mice; Mice, Inbred C57BL; Organic Chemicals; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Sex Characteristics; Tyrphostins | 2008 |
EGFR inhibitor enhances cisplatin sensitivity of oral squamous cell carcinoma cell lines.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Humans; Mouth Neoplasms; Quinazolines; Tyrphostins | 2008 |
Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Doxorubicin; ErbB Receptors; Glutathione; Hepatocytes; Male; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrphostins | 2008 |
MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.
Topics: Cell Line; ErbB Receptors; Genes, fos; Humans; Interleukin-8; Matrix Metalloproteinase 12; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Respiratory Mucosa; Tyrphostins | 2008 |
EGFR signalling is required for Paracentrotus lividus endomesoderm specification.
Topics: Animals; Blotting, Western; Cell Lineage; Embryo, Nonmammalian; Endoderm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; MAP Kinase Signaling System; Mesoderm; Paracentrotus; Quinazolines; Signal Transduction; Tyrphostins | 2008 |
Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes.
Topics: Animals; Cells, Cultured; Cumulus Cells; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Meiosis; Oocytes; Phosphorylation; Protein Kinase C; Quinazolines; Receptors, Androgen; Swine; Tetradecanoylphorbol Acetate; Tyrphostins | 2008 |
Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Cinnamates; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; Neuropilin-1; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transplantation, Heterologous; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2 | 2008 |
Effects of gangliosides on the differentiation of human mesenchymal stem cells into osteoblasts by modulating epidermal growth factor receptors.
Topics: Alkaline Phosphatase; Cell Differentiation; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Gangliosides; Humans; Mesenchymal Stem Cells; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2008 |
Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent.
Topics: Animals; Astrocytes; Butadienes; Cell Size; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Mice; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Quinazolines; Stimulation, Chemical; Transcriptional Activation; Tyrphostins; Vasopressins; Water | 2008 |
Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.
Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Cell Line; Down-Regulation; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Ligands; Lysosomes; Macrolides; Phosphoproteins; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Quinazolines; Recombinant Fusion Proteins; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Tyrphostins | 2008 |
Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.
Topics: Aminoquinolines; Aniline Compounds; Biological Assay; Drug Resistance; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Inhibitory Concentration 50; Morpholines; Mutant Proteins; Protein Kinase Inhibitors; Quinazolines; Substrate Specificity; Tyrphostins | 2008 |
EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src.
Topics: Adenosine Triphosphate; Bronchi; Cell Line; Chloride Channels; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Patch-Clamp Techniques; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Recombinant Proteins; Signal Transduction; Tyrphostins | 2008 |
Arsenite suppresses Notch1 signaling in human keratinocytes.
Topics: Amyloid Precursor Protein Secretases; Arsenites; Calcium-Binding Proteins; Cell Differentiation; Enzyme Inhibitors; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Keratinocytes; Membrane Proteins; Models, Biological; Protein Binding; Quinazolines; Receptor, Notch1; Receptors, Notch; Serrate-Jagged Proteins; Signal Transduction; Skin Neoplasms; Tyrphostins | 2009 |
The epidermal growth factor receptor mediates allergic airway remodelling in the rat.
Topics: Allergens; Animals; Cell Proliferation; Cysteine; ErbB Receptors; Gene Expression Profiling; Goblet Cells; Hyperplasia; Inflammation; Leukotriene D4; Muscle, Smooth; Ovalbumin; Quinazolines; Rats; Receptors, Leukotriene; Tyrphostins | 2008 |
Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent.
Topics: ADAM Proteins; Cell Movement; Cells, Cultured; Coronary Vessels; Dipeptides; ErbB Receptors; Fibrinolysin; Heparin-binding EGF-like Growth Factor; Humans; Insulin; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Phosphorylation; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Quinazolines; Receptor Cross-Talk; Signal Transduction; Somatomedins; Tyrphostins | 2008 |
The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity.
Topics: Animals; Anticoagulants; Cell Line; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 2; Hemostatics; Heparin; Humans; Hydroxamic Acids; Ionomycin; Ionophores; Metalloproteases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Quinazolines; Rats; src-Family Kinases; Thrombin; Transcriptional Activation; Tyrphostins | 2008 |
HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells.
Topics: Betacellulin; Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Female; Genes, erbB-2; Humans; Intercellular Signaling Peptides and Proteins; Neuregulin-1; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Tyrphostins | 2008 |
Tyrphostin AG1478 suppresses proliferation and invasion of human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme Inhibitors; ErbB Receptors; Female; Flow Cytometry; Gene Expression; Humans; Matrix Metalloproteinase 9; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Telomerase; Tyrphostins | 2008 |
Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478.
Topics: Cell Line, Tumor; Cell Membrane; Cell Survival; Epidermal Growth Factor; ErbB Receptors; Humans; Lysosomes; Phosphorylation; Photosensitizing Agents; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2008 |
Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.
Topics: Aminopyridines; Animals; Antidepressive Agents, Second-Generation; Astrocytes; Butadienes; Calcium; Cells, Cultured; Chelating Agents; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fluorobenzenes; Fluoxetine; Gene Expression; Indoles; Maleimides; Mice; Nitriles; Phosphorylation; Piperidines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Quinazolines; Receptor, Serotonin, 5-HT2B; RNA, Messenger; Signal Transduction; Substrate Specificity; Transcriptional Activation; Tyrphostins; Up-Regulation; Urea | 2008 |
DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies.
Topics: Animals; Antibodies, Monoclonal; Cancer Vaccines; Cell Growth Processes; Female; Gefitinib; Karyotyping; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Quinazolines; Receptor, ErbB-2; Signal Transduction; T-Lymphocytes, Cytotoxic; Tyrphostins; Vaccines, DNA | 2008 |
A novel small molecule regulator of guanine nucleotide exchange activity of the ADP-ribosylation factor and golgi membrane trafficking.
Topics: Biological Transport, Active; Brefeldin A; Cell Line; Golgi Apparatus; Guanine Nucleotide Exchange Factors; Humans; Intracellular Membranes; Mutation; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Quinazolines; Tyrphostins | 2008 |
Delta-opioid receptors activate ERK/MAP kinase via integrin-stimulated receptor tyrosine kinases.
Topics: Cells, Cultured; Enkephalin, Leucine-2-Alanine; ErbB Receptors; Estrenes; Etorphine; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oligopeptides; Phosphorylation; Protein Kinase C-delta; Pyrrolidinones; Quinazolines; Receptors, Opioid, delta; Type C Phospholipases; Tyrphostins | 2008 |
Low density lipoproteins transactivate EGF receptor: role in mesangial cell proliferation.
Topics: Animals; Cell Proliferation; Cells, Cultured; ErbB Receptors; Humans; Lipoproteins, LDL; MAP Kinase Signaling System; Mesangial Cells; Mice; Oxidative Stress; Phosphorylation; Quinazolines; ras Proteins; Tyrphostins | 2008 |
The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.
Topics: Animals; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Isoenzymes; Liver Neoplasms; Mitochondria; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Rats; Reactive Oxygen Species; RNA, Small Interfering; Transforming Growth Factor beta; Tyrphostins | 2009 |
A role for SNX5 in the regulation of macropinocytosis.
Topics: Animals; Carrier Proteins; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophage Activation; Macrophages; Membrane Lipids; Membrane Proteins; Mice; Phosphatidylinositol Phosphates; Pinocytosis; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; Sorting Nexins; Transgenes; Tyrphostins; Vesicular Transport Proteins | 2008 |
Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Combined Modality Therapy; Docetaxel; Dose-Response Relationship, Radiation; Enzyme Inhibitors; ErbB Receptors; Humans; Isothiocyanates; Lutetium; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Pentetic Acid; Phosphorylation; Prostatic Neoplasms; Quinazolines; Radiation-Sensitizing Agents; Radioimmunotherapy; Radioisotopes; Taxoids; Tyrphostins; Xenograft Model Antitumor Assays | 2009 |
Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.
Topics: Adenocarcinoma; Amphiregulin; Autoantibodies; Cell Line, Tumor; Cell Proliferation; EGF Family of Proteins; ErbB Receptors; Esophageal Neoplasms; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Leptin; Matrix Metalloproteinases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transforming Growth Factor alpha; Tyrphostins | 2008 |
c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1.
Topics: Cell Cycle; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinases; Cycloheximide; ErbB Receptors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hepatocytes; Humans; Kinetics; Phosphorylation; Protein Kinase Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; Transfection; Tyrphostins; Up-Regulation | 2008 |
Receptor overexpression or inhibition alters cell surface dynamics of EGF-EGFR interaction: new insights from real-time single molecule analysis.
Topics: Cell Membrane; Dimerization; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Microscopy, Fluorescence; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2009 |
Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions.
Topics: alpha Catenin; Animals; Anoikis; beta Catenin; Cadherins; Cell Adhesion; Endocytosis; Enterocytes; ErbB Receptors; Intestine, Small; Mice; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tight Junctions; Tyrphostins | 2009 |
Stretching the search for therapeutic targets in acute lung injury.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Humans; Protein Kinase Inhibitors; Quinazolines; Respiratory Distress Syndrome; Tyrphostins | 2008 |
Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Intubation, Intratracheal; Mice; Mice, Inbred Strains; Neutrophils; Permeability; Protein Tyrosine Phosphatases; Pulmonary Alveoli; Quinazolines; Signal Transduction; Tyrphostins; Ventilator-Induced Lung Injury; Ventilators, Mechanical | 2008 |
Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic CMP; Dose-Response Relationship, Drug; Down-Regulation; Endocrine Disruptors; Enzyme Activators; Epidermal Growth Factor; ErbB Receptors; Genistein; Leydig Cells; Luteinizing Hormone; Male; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Long-Evans; Receptors, LH; Signal Transduction; Testosterone; Tyrphostins | 2009 |
Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Flow Cytometry; Humans; Immunohistochemistry; Neoplasm Proteins; Protein Kinase Inhibitors; Quinazolines; Tritium; Tyrphostins | 2009 |
Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Blotting, Western; Carcinoid Tumor; Celecoxib; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; ErbB Receptors; Female; Humans; Insulinoma; Male; Mice; Mice, Transgenic; Middle Aged; Pancreatic Neoplasms; Pyrazoles; Quinazolines; Sulfonamides; Tumor Cells, Cultured; Tyrphostins; Young Adult | 2009 |
Role of epidermal growth factor gene in the development of pancreatic cancer and efficiency of inhibitors of this gene in the treatment of pancreatic carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Proliferation; Drug Evaluation, Preclinical; Epidermal Growth Factor; ErbB Receptors; Fluorouracil; Gene Frequency; Genetic Predisposition to Disease; Humans; Pancreatic Neoplasms; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Quinazolines; Time Factors; Tumor Cells, Cultured; Tyrphostins | 2008 |
Functions of epidermal growth factor receptor in cisplatin response of thyroid cells.
Topics: Animals; Apoptosis; Cell Line; Cisplatin; Dose-Response Relationship, Drug; ErbB Receptors; p38 Mitogen-Activated Protein Kinases; Quinazolines; Rats; Reactive Oxygen Species; Signal Transduction; Thyroid Gland; Tyrphostins | 2009 |
Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.
Topics: Butadienes; Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Cyclooxygenase 2; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Nitriles; Ovarian Neoplasms; Pertussis Toxin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; Quinazolines; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins | 2008 |
The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Erlotinib Hydrochloride; Female; Humans; Mitoxantrone; Neoplasm Proteins; Quinazolines; Tyrphostins | 2009 |
Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Cells, Cultured; Dexamethasone; Fibrosis; Humans; Kidney Tubules, Proximal; Plasminogen Activator Inhibitor 1; Protein-Tyrosine Kinases; Quinazolines; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrphostins | 2009 |
Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor.
Topics: Blotting, Western; Cell Line; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoprecipitation; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Transfection; Tyrosine; Tyrphostins | 2009 |
Chronic intermittent mechanical stress increases MUC5AC protein expression.
Topics: Bronchi; Bronchoconstriction; Cells, Cultured; Epithelial Cells; ErbB Receptors; Forkhead Transcription Factors; Gene Expression Regulation; Hepatocyte Nuclear Factor 3-beta; Humans; Microtubule Proteins; Mucin 5AC; Protein Kinase Inhibitors; Quinazolines; Stress, Mechanical; Transcription, Genetic; Transforming Growth Factor beta2; Tyrphostins | 2009 |
Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase.
Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dual Specificity Phosphatase 1; ErbB Receptors; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Mice; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Tyrphostins | 2009 |
Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma.
Topics: Active Transport, Cell Nucleus; Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Squamous Cell; Cell Line, Tumor; Cobalt; Cyclooxygenase 2; Epidermal Growth Factor; Female; Humans; Microscopy, Fluorescence; Models, Biological; Promoter Regions, Genetic; Quinazolines; RNA, Messenger; Tyrphostins; Uterine Cervical Neoplasms | 2009 |
Epidermal growth factor receptor is involved in clusterin-induced astrocyte proliferation.
Topics: Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Clusterin; Enzyme Activation; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogens; Phosphorylation; Proto-Oncogene Proteins c-raf; Quinazolines; Rats; RNA, Small Interfering; Signal Transduction; Tyrphostins | 2009 |
Desmoid cell motility is induced in vitro by rhEGF.
Topics: Benzamides; Cell Division; Cell Line, Tumor; Cell Movement; Culture Media, Serum-Free; Dioxoles; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibromatosis, Aggressive; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Integrin beta1; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Quinazolines; Receptors, Transforming Growth Factor beta; Recombinant Proteins; RNA, Messenger; RNA, Small Interfering; Soft Tissue Neoplasms; STAT3 Transcription Factor; Transforming Growth Factor alpha; Tyrphostins | 2009 |
Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium.
Topics: Brefeldin A; Bumetanide; Cell Line; Chlorides; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Humans; Ion Transport; Protein-Tyrosine Kinases; Quercetin; Quinazolines; Respiratory Mucosa; Signal Transduction; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Tyrphostins; Valinomycin | 2009 |
Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro.
Topics: Amphiregulin; Animals; Betacellulin; Cumulus Cells; EGF Family of Proteins; Embryonic Development; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Fertilization in Vitro; Glycoproteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Macaca mulatta; Oocytes; Phosphorylation; Pregnancy; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrphostins | 2009 |
Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.
Topics: Aged; Ankle; Becaplermin; Blood Pressure; Cell Proliferation; Cells, Cultured; Constriction, Pathologic; DNA Replication; Epidermal Growth Factor; Female; Fibroblasts; Graft Occlusion, Vascular; Heparin; Humans; Hyperplasia; Lower Extremity; Lysophospholipids; Male; Middle Aged; Myocytes, Smooth Muscle; Peripheral Vascular Diseases; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Saphenous Vein; Sphingosine; Thrombin; Time Factors; Tyrphostins; Ultrasonography, Doppler, Duplex; Vascular Patency | 2009 |
Activation of the calcium-sensing receptor by high calcium induced breast cancer cell proliferation and TRPC1 cation channel over-expression potentially through EGFR pathways.
Topics: Base Sequence; Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Dipeptides; DNA Primers; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Receptors, Calcium-Sensing; Transcriptional Activation; TRPC Cation Channels; Tyrphostins | 2009 |
Estradiol, progesterone, and transforming growth factor alpha regulate insulin-like growth factor binding protein-3 (IGFBP3) expression in mouse endometrial cells.
Topics: Animals; Blotting, Western; DNA; Endometrium; Enzyme Inhibitors; Epithelial Cells; Estradiol; Female; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Mice; Mice, Inbred ICR; Progesterone; Quinazolines; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Transforming Growth Factor alpha; Tyrphostins | 2009 |
A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
Topics: Angioplasty, Balloon; Animals; Carotid Artery Diseases; Carotid Stenosis; cdc42 GTP-Binding Protein; Cell Movement; Cells, Cultured; Disease Models, Animal; ErbB Receptors; Fibrinolytic Agents; Gene Transfer Techniques; Genetic Therapy; Guanine Nucleotide Exchange Factors; Hirudins; Humans; Muscle, Smooth, Vascular; Mutation; p21-Activated Kinases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Quinazolines; rac1 GTP-Binding Protein; Rats; Rho Guanine Nucleotide Exchange Factors; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Stress Fibers; Thrombin; Time Factors; Transfection; Tyrphostins | 2009 |
Receptor tyrosine kinases as mediators of injury-induced bradykinin B1 receptor expression in rabbit aortic smooth muscle.
Topics: Animals; Aorta; Bradykinin; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Interleukin-1; Muscle Contraction; Myocytes, Smooth Muscle; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Receptor, Bradykinin B1; Tyrphostins; Up-Regulation | 2009 |
Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; ErbB Receptors; Heme Oxygenase-1; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Quinazolines; RNA, Small Interfering; Tyrphostins | 2010 |
EGF-induced MMP-9 expression is mediated by the JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line.
Topics: Breast Neoplasms; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Matrix Metalloproteinase 9; Phosphorylation; Quinazolines; RNA, Messenger; RNA, Small Interfering; STAT3 Transcription Factor; Tyrphostins | 2009 |
Regulation and function of tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP3 in periovulatory rat granulosa cells.
Topics: Adenylyl Cyclases; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Chorionic Gonadotropin; Colforsin; Enzyme Inhibitors; Female; Granulosa Cells; Hormone Antagonists; Humans; Mifepristone; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Protein Kinase C; Protein Tyrosine Phosphatases; Quinazolines; Rats; Receptors, Progesterone; Reproductive Control Agents; RNA, Small Interfering; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3; Tyrphostins | 2009 |
Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism.
Topics: ADAM Proteins; ADAM10 Protein; Amyloid Precursor Protein Secretases; Cell Movement; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Humans; Hydroxamic Acids; Membrane Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peptide Fragments; Phosphorylation; Protease Inhibitors; Protein Kinase Inhibitors; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Time Factors; Tyrphostins; Urokinase-Type Plasminogen Activator | 2009 |
Downregulation of Notch1 and its potential correlation with epidermal growth factor receptor signalling in tongue squamous cell carcinoma.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Gene Silencing; Humans; Inverted Repeat Sequences; Metaplasia; Mouth Mucosa; Plasmids; Quinazolines; Receptor, Notch1; RNA; Signal Transduction; Tongue; Tongue Neoplasms; Transfection; Tyrphostins; Up-Regulation | 2010 |
Role of epidermal growth factor receptor (EGFR) in corneal remodelling in diabetes.
Topics: Animals; Collagen; Cornea; Corneal Stroma; Diabetes Mellitus, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Microscopy, Electron; Proteoglycans; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tissue Distribution; Tyrphostins | 2009 |
Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment.
Topics: Androgens; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gemcitabine; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Receptor, ErbB-2; Time Factors; Tyrphostins | 2009 |
KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin.
Topics: Amphiregulin; Animals; beta Catenin; Cadherins; Cell Differentiation; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Glycoproteins; Hair Follicle; Hedgehog Proteins; Heparin-binding EGF-like Growth Factor; Hyaluronan Receptors; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Morphogenesis; Oncogene Proteins; Quinazolines; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Skin; Syndecan-1; Tissue Culture Techniques; Trans-Activators; Tyrphostins; Vibrissae; Wnt Proteins; Zinc Finger Protein GLI1 | 2009 |
Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway.
Topics: Cell Line, Tumor; Cell Movement; ErbB Receptors; Fibroblast Growth Factor 2; Humans; Kininogen, High-Molecular-Weight; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Protein Structure, Tertiary; Quinazolines; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Tyrphostins | 2009 |
[Effects of theaflavins on the signal transduction pathway of epidermal growth factor receptor in airway mucous hypersecretion].
Topics: Biflavonoids; Catechin; Cell Line, Tumor; ErbB Receptors; Humans; JNK Mitogen-Activated Protein Kinases; Mucin 5AC; Phosphorylation; Quinazolines; Respiratory Mucosa; Signal Transduction; Tyrphostins | 2009 |
ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.
Topics: Animals; Anticoagulants; Astrocytes; Blotting, Western; Brain Chemistry; Dexmedetomidine; Dipeptides; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Heparin; Hypnotics and Sedatives; Immunoprecipitation; Male; Mice; Phosphorylation; Protease Inhibitors; Quinazolines; Receptors, Adrenergic, alpha-2; Transcriptional Activation; Tyrphostins | 2009 |
Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.
Topics: Cells, Cultured; Collagen Type I; Culture Media; Enzyme Inhibitors; Enzyme Precursors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gelatinases; Gingiva; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Matrix Metalloproteinase 14; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptors, Cell Surface; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Tyrphostins | 2009 |
Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor.
Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; ErbB Receptors; fas Receptor; Fas-Associated Death Domain Protein; Hepatocytes; Liver; Liver Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nitrobenzenes; Quinazolines; Sulfonamides; Tyrphostins; Up-Regulation | 2009 |
MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.
Topics: Adult; Aged; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MicroRNAs; Middle Aged; Mutation; Quinazolines; RNA, Antisense; Signal Transduction; Smoking; Tyrphostins | 2009 |
EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.
Topics: Animals; Blood Glucose; Cells, Cultured; Collagen Type I; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Estrenes; Female; Male; Mesangial Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Proto-Oncogene Proteins c-akt; Pyrrolidinones; Quinazolines; Rats; Rats, Sprague-Dawley; RNA Interference; Tyrphostins; Up-Regulation | 2009 |
Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia.
Topics: Analysis of Variance; Animals; Axons; Carbazoles; Cell Proliferation; Cells, Cultured; Central Nervous System; Culture Media, Conditioned; Cyclic AMP; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Ganglia, Spinal; Glial Fibrillary Acidic Protein; Indole Alkaloids; Myelin Sheath; Nerve Crush; Nerve Growth Factors; Neuroglia; Neurons; Quinazolines; Rats; RNA, Small Interfering; S100 Proteins; Transfection; Tyrphostins | 2009 |
[Analysis of tyrphostin AG1478 effect on behavior of internalized EGF receptor at different stages of endocytosis].
Topics: Cell Line, Tumor; Endocytosis; Enzyme Inhibitors; ErbB Receptors; Humans; Protein Tyrosine Phosphatases; Quinazolines; Tyrphostins | 2009 |
Naegleria fowleri induces MUC5AC and pro-inflammatory cytokines in human epithelial cells via ROS production and EGFR activation.
Topics: Animals; Cell Line; Central Nervous System Protozoal Infections; Dimethyl Sulfoxide; Epithelial Cells; ErbB Receptors; Humans; Immunity, Innate; Interleukin-1beta; Interleukin-8; Male; Mice; Mice, Inbred BALB C; Mucin 5AC; Naegleria fowleri; Neutrophils; Quinazolines; Reactive Oxygen Species; Trophozoites; Tyrphostins | 2009 |
Effects of cigarette smoking on mucin production in human middle ear epithelial cells.
Topics: Analysis of Variance; Blotting, Western; Cells, Cultured; Ear, Middle; Epithelial Cells; ErbB Receptors; Humans; Mucins; Otitis Media; Quinazolines; Reference Values; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Smoke; Smoking; Tumor Necrosis Factor-alpha; Tyrphostins; Up-Regulation | 2009 |
Effect of epidermal growth factor receptor inhibitor alone and in combination with cisplatin on growth of vulvar cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Tyrphostins; Vulvar Neoplasms | 2009 |
Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin.
Topics: Analysis of Variance; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Shape; Enzyme Inhibitors; Female; Fibronectins; Gene Knockdown Techniques; Homeodomain Proteins; Humans; Immunohistochemistry; Integrin alpha5; Integrin beta1; Ovarian Neoplasms; Quinazolines; RNA, Small Interfering; Signal Transduction; Transcription Factors; Tyrphostins | 2009 |
Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology.
Topics: Adipose Tissue; Adult; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Flow Cytometry; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mesenchymal Stem Cells; Microspheres; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Tyrphostins | 2009 |
Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.
Topics: Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Computational Biology; Epidermal Growth Factor; Humans; Immunoassay; Least-Squares Analysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multivariate Analysis; Osteogenesis; Phosphoproteins; Phosphotransferases; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Stem Cells; Stromal Cells; Tyrphostins | 2009 |
Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cobra Cardiotoxin Proteins; Elapid Venoms; ErbB Receptors; Humans; Membrane Potential, Mitochondrial; Phosphorylation; Protein Conformation; Proto-Oncogene Proteins c-akt; Quinazolines; Tyrphostins | 2009 |
Early weaning accelerates the differentiation of mucous neck cells in rat gastric mucosa: possible role of TGFalpha/EGFR.
Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; ErbB Receptors; Female; Gastric Mucosa; Gene Expression Regulation, Developmental; Immunoenzyme Techniques; Mucin-6; Quinazolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor alpha; Tyrphostins; Weaning | 2010 |
Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Axons; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP; ErbB Receptors; Female; Humans; Mice; Nerve Growth Factors; Nerve Regeneration; Neuroglia; Optic Nerve; Quinazolines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar; Receptor, trkA; Receptor, trkB; Receptor, trkC; Recombinant Fusion Proteins; Retinal Ganglion Cells; RNA, Small Interfering; Tyrphostins | 2009 |
Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Butadienes; Cell Culture Techniques; Cell Migration Assays; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; src-Family Kinases; Syk Kinase; Transcriptional Activation; Tyrphostins | 2010 |
Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.
Topics: Acetophenones; Active Transport, Cell Nucleus; Aldosterone; Animals; Benzopyrans; Cell Line; Cell Proliferation; Cytoplasm; Enzyme Activation; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Kidney Cortex; Kidney Tubules, Collecting; Mice; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphorylation; Protein Binding; Protein Kinase C-delta; Protein Kinase Inhibitors; Quinazolines; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; TRPP Cation Channels; Tyrphostins | 2010 |
Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.
Topics: 3T3-L1 Cells; Adipogenesis; Animals; Blotting, Western; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Mice; Mice, Knockout; Phosphorylation; Plant Extracts; Protein Kinase C-alpha; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; TRPV Cation Channels; Tyrphostins | 2009 |
Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Green Fluorescent Proteins; Humans; Mutation; Nerve Tissue Proteins; Neurons; Oxidative Stress; Quinazolines; Signal Transduction; Stem Cells; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Tyrphostins | 2010 |
JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells.
Topics: Amino Acids, Cyclic; Anthracenes; Calcium; Carbachol; Cell Line; Cell Polarity; Chlorides; Cholinergic Agonists; Colon; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Phosphorylation; Potassium; Quinazolines; Thapsigargin; Tyrphostins | 2010 |
Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells.
Topics: Angiotensin II; Animals; Cell Line; Enzyme Inhibitors; ErbB Receptors; Hepatocytes; Insulin; Insulin Resistance; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Receptor, Insulin; Serine; Signal Transduction; Threonine; Transcriptional Activation; Tyrphostins; Vasoconstrictor Agents | 2010 |
The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; Chromones; Enzyme Inhibitors; ErbB Receptors; Immunohistochemistry; In Vitro Techniques; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neurons; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; RNA Interference; SOXB1 Transcription Factors; Tyrphostins | 2010 |
Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern.
Topics: Animals; Cell Differentiation; Larva; Melanins; Melanocytes; Mutation; Phenylthiourea; Pigmentation; Quinazolines; Receptor Protein-Tyrosine Kinases; Regeneration; Stem Cells; Time Factors; Tyrphostins; Zebrafish | 2010 |
Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.
Topics: Animals; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; ErbB Receptors; Humans; Insulin Receptor Substrate Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Myocytes, Smooth Muscle; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, IGF Type 1; Receptor, Insulin; Tyrphostins; Up-Regulation; Zinc | 2010 |
Termination of tyrphostin AG1478 application results in different recovery of EGF receptor tyrosine residues 1045 and 1173 phosphorylation in A431 cells.
Topics: Cell Line, Tumor; Endocytosis; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proto-Oncogene Proteins c-cbl; Quinazolines; Tyrosine; Tyrphostins; Ubiquitination | 2009 |
Nanoscale imaging of epidermal growth factor receptor clustering: effects of inhibitors.
Topics: Cell Membrane; Dimerization; Enzyme Inhibitors; ErbB Receptors; HeLa Cells; Humans; Membrane Microdomains; Microscopy; Microscopy, Confocal; Nanotechnology; Prognosis; Protein Structure, Tertiary; Quinazolines; Tyrphostins | 2010 |
Effect of urotensin II on PC12 rat pheochromocytoma cells.
Topics: Amino Acid Sequence; Animals; Cell Proliferation; Chromaffin Cells; DNA; Dopamine; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Quinazolines; Rats; Receptors, G-Protein-Coupled; RNA, Messenger; Tyrosine 3-Monooxygenase; Tyrphostins; Urotensins | 2010 |
Contribution of epidermal growth factor receptor transactivation in angiotensin II-induced enhanced expression of Gi protein and proliferation in A10 vascular smooth muscle cells.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Blotting, Western; Cell Line; Cell Proliferation; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gi-Go; Imidazoles; Losartan; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pyridines; Quinazolines; Rats; Receptors, Angiotensin; Transcriptional Activation; Tyrphostins | 2009 |
Role of epidermal growth factor receptor in ovine fetal pulmonary vascular remodeling following exposure to high altitude long-term hypoxia.
Topics: Actins; Altitude; Animals; Cell Proliferation; Cells, Cultured; ErbB Receptors; Female; Fetal Hypoxia; Muscle, Smooth, Vascular; Pregnancy; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Quinazolines; Sheep, Domestic; Tyrphostins | 2009 |
New platform for controlled and sustained delivery of the EGF receptor tyrosine kinase inhibitor AG1478 using poly(lactic-co-glycolic acid) microspheres.
Topics: Animals; Carcinoma; Cell Line; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Humans; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protein-Tyrosine Kinases; Quinazolines; Rats; Tyrphostins | 2010 |
P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells.
Topics: ADAM Proteins; ADAM10 Protein; ADAM17 Protein; Amyloid Precursor Protein Secretases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Membrane Proteins; Metalloproteases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuregulin-1; Phosphorylation; Protein Multimerization; Purinergic P2 Receptor Agonists; Quinazolines; Receptor, ErbB-3; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; RNA, Small Interfering; Salivary Glands; Signal Transduction; Tyrphostins | 2010 |
Epidermal growth factor receptor as a target for anti-proliferative treatment of proliferative cholangitis in hepatolithiasis.
Topics: Animals; Bromodeoxyuridine; Cell Division; Cholangitis; Collagen Type I; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; fas Receptor; Fibrosis; Gene Expression; In Situ Nick-End Labeling; Ki-67 Antigen; Lithiasis; Male; Mucin 5AC; Quinazolines; Rats; Rats, Sprague-Dawley; Recurrence; Tyrphostins | 2011 |
Epidermal growth factor can be used in lieu of follicle-stimulating hormone for nuclear maturation of porcine oocytes in vitro.
Topics: Animals; Cell Nucleus; Cells, Cultured; Drug Interactions; Embryo Culture Techniques; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Growth Factor; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Oocytes; Oogenesis; Protein Biosynthesis; Quinazolines; Swine; Therapeutic Equivalency; Tyrphostins | 2010 |
Insulin-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro.
Topics: 3T3-L1 Cells; ADAM Proteins; ADAM17 Protein; Adipocytes; Alkaline Phosphatase; Animals; Cell Differentiation; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Insulin; Intercellular Signaling Peptides and Proteins; Mice; Quinazolines; Recombinant Proteins; Tyrphostins | 2010 |
Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.
Topics: Arginase; Cell Hypoxia; Cell Proliferation; Endothelial Cells; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Lung; Microvessels; Models, Biological; Quinazolines; RNA, Messenger; RNA, Small Interfering; Time Factors; Tyrphostins; Urea | 2010 |
The constitutive activity of epidermal growth factor receptor vIII leads to activation and differential trafficking of wild-type epidermal growth factor receptor and erbB2.
Topics: Cell Line, Tumor; Dimerization; DNA Primers; ErbB Receptors; Female; Humans; Immunoblotting; Microscopy, Confocal; Mutation; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Polymerase Chain Reaction; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; RNA, Messenger; Tyrphostins | 2010 |
[Effect of epidermal growth factor receptor on airway remodeling in asthmatic mice and its mechanism].
Topics: Airway Remodeling; Animals; Asthma; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Male; Mice; Quinazolines; Tyrphostins | 2010 |
Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Carcinoma, Squamous Cell; Cell Line, Tumor; Diterpenes, Kaurane; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Fas-Associated Death Domain Protein; Humans; Laryngeal Neoplasms; Membrane Potential, Mitochondrial; Oxidative Stress; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Reactive Oxygen Species; Signal Transduction; Sirtuin 1; Tyrphostins | 2010 |
EGF receptor activation during allergic sensitization affects IL-6-induced T-cell influx to airways in a rat model of asthma.
Topics: Allergens; Animals; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Separation; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Interleukin-6; Lung; Ovalbumin; Quinazolines; Rats; Rats, Inbred BN; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tyrphostins | 2010 |
Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo.
Topics: Ammonia; Animals; Astrocytes; Blotting, Western; Brain; Cell Membrane; Cells, Cultured; Dipeptides; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Genes, src; Hyperammonemia; Isoenzymes; Mice; Protease Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Tyrphostins; Urease | 2010 |
Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors.
Topics: Animals; Astrocytes; Blotting, Western; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; ErbB Receptors; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protease Inhibitors; Quinazolines; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; RNA, Small Interfering; Serotonin; Substrate Specificity; Transcriptional Activation; Tyrphostins | 2010 |
Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.
Topics: Animals; Cell Line, Tumor; Dependovirus; ErbB Receptors; Female; Gefitinib; Gene Expression; Genetic Therapy; Genetic Vectors; Head and Neck Neoplasms; Isoantigens; Mice; Mice, Nude; Neoplasms, Experimental; Quinazolines; Receptors, Virus; Transduction, Genetic; Tyrphostins | 2010 |
The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics.
Topics: Adenosine Triphosphate; Anthracenes; Antimicrobial Cationic Peptides; Calcium-Calmodulin-Dependent Protein Kinases; Cathelicidins; Cell Movement; Cells, Cultured; Dental Pulp; Endodontics; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Protein Tyrosine Phosphatases; Purinergic P2 Receptor Agonists; Quinazolines; Receptors, Cell Surface; Receptors, Purinergic P2X; Regenerative Medicine; Tissue Engineering; Tyrphostins | 2010 |
Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication.
Topics: Animals; Cell Line; Chlorocebus aethiops; Cricetinae; Enterovirus B, Human; Enzyme Inhibitors; Golgi Apparatus; Guanine Nucleotide Exchange Factors; Humans; Pyridines; Quinazolines; Quinolines; Tyrphostins; Virus Replication | 2010 |
Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling.
Topics: Animals; Epidermal Growth Factor; Epidermis; Epiregulin; ErbB Receptors; Fatty Acid Transport Proteins; Keratinocytes; Mice; Mice, Mutant Strains; Mice, Transgenic; Mutation; Phenotype; Quinazolines; Signal Transduction; Skin; Skin Diseases; STAT3 Transcription Factor; Tyrphostins | 2010 |
The overexpression of heparin-binding epidermal growth factor is responsible for Th17-induced airway remodeling in an experimental asthma model.
Topics: Adoptive Transfer; Airway Remodeling; Animals; Antibodies, Monoclonal; Asthma; Blotting, Western; Cytokines; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Interleukin-17; Lung; Male; Mice; Mice, Inbred C57BL; Mucus; Ovalbumin; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Helper-Inducer; Tyrphostins | 2010 |
Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells.
Topics: Benzoxazines; Blotting, Western; Capsaicin; Cell Movement; Cell Proliferation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Humans; Interleukin-6; Interleukin-8; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Pyrazoles; Quinazolines; Receptor, Cannabinoid, CB1; Transcriptional Activation; TRPV Cation Channels; Tyrphostins | 2010 |
GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation.
Topics: Animals; Bacterial Proteins; Cell Line; Cell Proliferation; Culture Media, Conditioned; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Keratinocytes; Mice; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Receptors, G-Protein-Coupled; STAT3 Transcription Factor; Transcriptional Activation; Tyrphostins | 2010 |
EGFR signaling is differentially activated in patient-derived glioblastoma stem cells.
Topics: Cell Line, Tumor; ErbB Receptors; Erlotinib Hydrochloride; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Signal Transduction; Tyrphostins | 2010 |
Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH.
Topics: Amphiregulin; Animals; Cyclic GMP; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Gap Junctions; Glycoproteins; Immunoblotting; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Meiosis; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Ovarian Follicle; Quinazolines; Tyrphostins | 2010 |
Role of matrix metalloproteinase-9 dimers in cell migration: design of inhibitory peptides.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; ErbB Receptors; Humans; Hyaluronan Receptors; Matrix Metalloproteinase 9; Models, Molecular; Mutation; Oligopeptides; Protein Binding; Protein Conformation; Protein Multimerization; Protein Structure, Tertiary; Quinazolines; RNA Interference; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Transfection; Tyrphostins | 2010 |
[Effects of EGFR inhibitor AG1478 in combination with celecoxib on the growth of gastric cancer cells].
Topics: Celecoxib; Cell Line, Tumor; Cell Proliferation; Drug Synergism; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proliferating Cell Nuclear Antigen; Pyrazoles; Quinazolines; Stomach Neoplasms; Sulfonamides; Tyrphostins | 2010 |
Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; ErbB Receptors; Gene Silencing; Gene Transfer Techniques; Glioblastoma; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; Quinazolines; RNA, Messenger; Tyrphostins | 2010 |
Effect of additional inhibition of human epidermal growth factor receptor 2 with the bispecific tyrosine kinase inhibitor AEE788 on the resistance to specific EGFR inhibition in glioma cells.
Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Glioblastoma; Humans; Protein Kinase Inhibitors; Purines; Quinazolines; Receptor, ErbB-2; Tyrphostins | 2010 |
The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways.
Topics: Alprostadil; Animals; Arrestins; beta-Arrestins; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Gefitinib; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; GTP-Binding Proteins; Keratinocytes; Mice; Mitogen-Activated Protein Kinase 3; Multiprotein Complexes; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; Skin; src-Family Kinases; STAT3 Transcription Factor; Tyrphostins | 2010 |
Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzimidazoles; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; DNA Topoisomerases, Type I; DNA, Neoplasm; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Genotype; Humans; Lung Neoplasms; Mutation; Neoplasm Proteins; Polymerase Chain Reaction; Protein Tyrosine Phosphatases; Quinazolines; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Tyrphostins | 2010 |
α1-Adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor.
Topics: Animals; Aorta, Thoracic; ErbB Receptors; Male; Quinazolines; Random Allocation; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Transcriptional Activation; Tyrphostins; Vasoconstriction | 2010 |
Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensors.
Topics: Angiotensin II; Arrestins; beta-Arrestins; Biosensing Techniques; Endoplasmic Reticulum; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; HEK293 Cells; Humans; Luminescent Measurements; Oncogene Protein p21(ras); Quinazolines; Receptor, Angiotensin, Type 1; Signal Transduction; trans-Golgi Network; Tyrphostins | 2011 |
Mechanisms of myogenic tone of coronary arteriole: Role of down stream signaling of the EGFR tyrosine kinase.
Topics: Animals; Arterioles; Cells, Cultured; Coronary Vessels; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; Janus Kinases; Mice; Mice, Inbred C57BL; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Nitroprusside; Phosphorylation; Potassium Chloride; Pressure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Son of Sevenless Proteins; STAT Transcription Factors; STAT3 Transcription Factor; Tyrphostins; Vasoconstriction; Vasodilation | 2011 |
Epidermal growth factor treatment switches δ-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism.
Topics: Blotting, Western; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Microfluidics; Microscopy, Confocal; Phosphorylation; Quinazolines; Receptor, IGF Type 1; Receptors, Opioid, delta; Transcriptional Activation; Tyrphostins | 2011 |
EGF-dependent induction of BCL-xL and p21CIP1/WAF1 is highly variable in HNSCC cells--implications for EGFR-targeted therapies.
Topics: bcl-X Protein; Blotting, Western; Carcinoma, Squamous Cell; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Head and Neck Neoplasms; Humans; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins | 2010 |
The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.
Topics: Antineoplastic Agents; Bone Neoplasms; Cell Proliferation; Chordoma; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; ErbB Receptors; Humans; In Situ Hybridization, Fluorescence; Mutation; Neoplasm Proteins; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Skull Base Neoplasms; Tumor Cells, Cultured; Tyrphostins | 2011 |
Endosomal signalling of epidermal growth factor receptors contributes to EGF-stimulated cell cycle progression in primary hepatocytes.
Topics: Animals; Cell Cycle; Cell Division; Endosomes; Epidermal Growth Factor; ErbB Receptors; Hepatocytes; Male; Microscopy, Confocal; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Thymidine; Tyrphostins | 2011 |
EGFR codon 497 polymorphism - implications for receptor sensitivity to inhibitors in HNSCC cell lines.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cetuximab; Codon; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Head and Neck Neoplasms; Humans; Polymorphism, Genetic; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins | 2011 |
ERK phosphorylation predicts synergism between gemcitabine and the epidermal growth factor receptor inhibitor AG1478.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gemcitabine; Humans; Mutation; Nitriles; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; RNA, Small Interfering; Tyrphostins | 2011 |
Bile acids promote HCV replication through the EGFR/ERK pathway in replicon-harboring cells.
Topics: Antiviral Agents; Bile Acids and Salts; Cell Cycle; Cell Line; Chenodeoxycholic Acid; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Genes, Reporter; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Interphase; Luciferases, Renilla; Promoter Regions, Genetic; Quinazolines; Transcriptional Activation; Tyrphostins; Viral Nonstructural Proteins; Virus Replication | 2011 |
EGFR is involved in control of gastric cell proliferation through activation of MAPK and Src signalling pathways in early-weaned rats.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Gastric Mucosa; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitosis; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Signal Transduction; src-Family Kinases; Tyrphostins | 2011 |
Inhibiting epidermal growth factor receptor attenuates reactive astrogliosis and improves functional outcome after spinal cord injury in rats.
Topics: Animals; Astrocytes; Behavior, Animal; Blotting, Western; ErbB Receptors; Female; Gliosis; Immunohistochemistry; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Tyrphostins | 2011 |
Epithelial growth factor receptor tyrosine kinase inhibitor prevents infiltration and cerebrospinal fluid dissemination in malignant glioma: an experimental study.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Cadherins; Cell Line; Enzyme Inhibitors; ErbB Receptors; Glioma; Male; Neoplasms, Experimental; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins; Up-Regulation | 2011 |
Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling.
Topics: Blotting, Western; Cyclin-Dependent Kinase Inhibitor p27; Epidermal Growth Factor; ErbB Receptors; HEK293 Cells; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Multimerization; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptors, Somatostatin; RNA Interference; Signal Transduction; Somatostatin; Tyrphostins | 2011 |
Expression and regulation of amphiregulin in Gsα-mutated human bone marrow stromal cells of fibrous dysplasia of mandible.
Topics: Adolescent; Amino Acid Substitution; Amphiregulin; Arginine; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Coloring Agents; DNA Mutational Analysis; EGF Family of Proteins; Enzyme Inhibitors; ErbB Receptors; Female; Fibrous Dysplasia of Bone; Glycoproteins; GTP-Binding Protein alpha Subunits, Gs; Humans; Intercellular Signaling Peptides and Proteins; Mandibular Diseases; Mutation, Missense; Osteoblasts; Polymorphism, Restriction Fragment Length; Quinazolines; Signal Transduction; Stromal Cells; Tetrazolium Salts; Tyrphostins | 2011 |
Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.
Topics: Blotting, Western; Cell Proliferation; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Glioblastoma; Humans; Immunoprecipitation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-3; Receptor, ErbB-4; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2011 |
Airway epithelial epidermal growth factor receptor mediates hogbarn dust-induced cytokine release but not Ca2+ response.
Topics: Air Pollutants, Occupational; Animal Husbandry; Animals; Antibodies, Neutralizing; Bronchi; Calcium; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Dust; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Interleukin-6; Interleukin-8; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Respiratory Mucosa; Swine; Tyrphostins | 2011 |
GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovary.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Butadienes; Cyclic AMP-Dependent Protein Kinases; Doxycycline; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Gonadotropins, Equine; Humans; Luteinizing Hormone; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Nitriles; Ovarian Follicle; Ovary; Progesterone; Quinazolines; Receptor Cross-Talk; Receptors, Corticotropin; Receptors, LH; Signal Transduction; Tyrphostins | 2011 |
Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis.
Topics: Animals; Benzamides; C-Reactive Protein; Cell Adhesion Molecules; Cumulus Cells; Dioxoles; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation, Developmental; Glucuronosyltransferase; Hyaluronic Acid; Isoquinolines; Meiosis; Mice; Oocytes; Progesterone; Pyridines; Pyrroles; Quinazolines; Serum Amyloid P-Component; Signal Transduction; Smad2 Protein; Smad3 Protein; Swine; Tyrphostins | 2011 |
Chronic mechanical stress induces mucin 5AC expression in human bronchial epithelial cells through ERK dependent pathways.
Topics: Analysis of Variance; Blotting, Western; Bronchi; Bronchoconstriction; Cells, Cultured; DNA Primers; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Flavonoids; Focal Adhesion Kinase 1; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Mucin 5AC; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Stress, Physiological; Tyrphostins | 2012 |
Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.
Topics: Antineoplastic Agents; Biological Availability; Caffeic Acids; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromones; Curcuma; Curcumin; Drug Therapy, Combination; Enzyme Inhibitors; ErbB Receptors; Humans; Morpholines; NF-kappa B; Phenylethyl Alcohol; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Pyrimidines; Quinazolines; Receptors, Fibroblast Growth Factor; Signal Transduction; Somatomedins; Tyrphostins | 2012 |
Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
Topics: Administration, Rectal; Animals; Apoptosis; Bacterial Proteins; Colitis; Dextran Sulfate; Drug Evaluation, Preclinical; Enzyme Activation; Epithelial Cells; ErbB Receptors; Hydrogels; Intestinal Mucosa; Lacticaseibacillus rhamnosus; Mice; Mice, Inbred C57BL; Microspheres; Oxazolone; Permeability; Probiotics; Proto-Oncogene Proteins c-akt; Quinazolines; Recombinant Proteins; Signal Transduction; Tyrphostins | 2011 |
Nanospheres delivering the EGFR TKI AG1478 promote optic nerve regeneration: the role of size for intraocular drug delivery.
Topics: Animals; Axons; Coumarins; Drug Delivery Systems; ErbB Receptors; Female; Lactic Acid; Microscopy, Fluorescence; Microspheres; Models, Chemical; Nanospheres; Nerve Regeneration; Neurons; Optic Nerve; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Thiazoles; Tyrphostins | 2011 |
Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation.
Topics: beta-Cyclodextrins; Caveolin 1; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; ErbB Receptors; Humans; MAP Kinase Kinase Kinases; Ouabain; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-fyn; Pyrimidines; Quinazolines; Signal Transduction; Sodium-Potassium-Exchanging ATPase; src-Family Kinases; Tyrphostins | 2011 |
Cytosolic phospholipase A(2)α protects against Fas- but not LPS-induced liver injury.
Topics: Animals; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; ErbB Receptors; fas Receptor; Female; Galactosamine; Gene Expression; Group IV Phospholipases A2; Hepatocytes; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Quinazolines; Recombinant Proteins; Tyrphostins | 2011 |
Mislocalization of large ARF-GEFs as a potential mechanism for BFA resistance in COG-deficient cells.
Topics: Adaptor Proteins, Vesicular Transport; Animals; Brefeldin A; CHO Cells; Cricetinae; Cricetulus; Cytoplasm; Drug Resistance; Endoplasmic Reticulum; Fibroblasts; Golgi Apparatus; Golgi Matrix Proteins; Guanine Nucleotide Exchange Factors; Heat-Shock Proteins; HeLa Cells; Humans; Intracellular Membranes; Macrolides; Mannose-Binding Lectins; Membrane Proteins; Protein Transport; Proton-Translocating ATPases; Pyridines; Quinazolines; Quinolines; RNA, Small Interfering; Tyrphostins | 2011 |
EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Squamous Cell; Child; Child, Preschool; ErbB Receptors; Female; Gene Amplification; Genes, erbB-1; Humans; Mice; Mice, Nude; Middle Aged; Molecular Targeted Therapy; Mutation; Quinazolines; Tyrphostins; Up-Regulation; Uterine Cervical Neoplasms | 2011 |
The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.
Topics: Acetylcysteine; Aged; Aldehydes; Antimetabolites; Blotting, Western; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Cell Line, Tumor; ErbB Receptors; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Glutathione; Glutathione Transferase; Humans; Immunohistochemistry; Male; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tyrphostins | 2011 |
Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery.
Topics: Cell Communication; Cell Division; Cells, Cultured; Electric Impedance; Electroporation; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Male; Middle Aged; Permeability; Pulmonary Disease, Chronic Obstructive; Quinazolines; Respiratory Mucosa; Smoking; Tight Junctions; Tyrphostins; Wound Healing | 2012 |
Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway.
Topics: Anilides; Apoptosis; Carcinoma; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; HT29 Cells; Humans; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Tyrphostins | 2011 |
A competitive co-cultivation assay for cancer drug specificity evaluation.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluorescence; High-Throughput Screening Assays; Humans; Indoles; Kidney Neoplasms; Organ Specificity; Quinazolines; Reproducibility of Results; Sodium Azide; Sulfonamides; Tyrphostins | 2011 |
Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway.
Topics: Angiotensin I; Angiotensin II; Animals; Body Weight; Diabetes Mellitus; ErbB Receptors; Glucose; Hyperglycemia; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Quinazolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins | 2012 |
MET signaling in GABAergic neuronal precursors of the medial ganglionic eminence restricts GDNF activity in cells that express GFRα1 and a new transmembrane receptor partner.
Topics: Animals; Antibodies, Blocking; Cell Differentiation; Cell Movement; Chlorocebus aethiops; COS Cells; ErbB Receptors; GABAergic Neurons; Ganglia; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Indoles; Median Eminence; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Piperazines; Proto-Oncogene Proteins c-met; Quinazolines; Receptor, ErbB-4; Signal Transduction; Sulfonamides; Tyrphostins | 2011 |
ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Astrocytes; Brain Injuries; Cell Differentiation; Cell Proliferation; Dipeptides; Enzyme Activation; ErbB Receptors; Female; Immunohistochemistry; Intermediate Filament Proteins; Male; Mice; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Neurogenesis; Neurons; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transfection; Transforming Growth Factor alpha; Tyrphostins | 2011 |
EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization.
Topics: Animals; Cell Membrane; Ceramides; Cholesterol; Enzyme Activation; ErbB Receptors; Humans; Hydrogen Peroxide; Ligands; Mice; Models, Biological; NIH 3T3 Cells; Oxidative Stress; Phosphorylation; Protein Binding; Protein Multimerization; Protein Structure, Tertiary; Protein Transport; Pyrazoles; Pyrimidines; Quinazolines; src-Family Kinases; Temperature; Tyrphostins | 2011 |
Effect of heparin-binding EGF-like growth factor and amphiregulin on the MAP kinase-induced production of vascular endothelial growth factor by human granulosa cells.
Topics: Amphiregulin; Blotting, Western; Butadienes; Cell Line; Cell Proliferation; EGF Family of Proteins; Enzyme-Linked Immunosorbent Assay; Female; Glycoproteins; Granulosa Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Nitriles; Quinazolines; Tyrphostins; Vascular Endothelial Growth Factors | 2011 |
The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Synergism; ErbB Receptors; Fetus; Gene Knockdown Techniques; Hepatocytes; Humans; Liver Neoplasms; Quinazolines; Tyrphostins | 2011 |
Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells.
Topics: Animals; Cell Culture Techniques; Cell Proliferation; Cell Separation; Cells, Cultured; Epidermal Growth Factor; Epigen; Epithelial Cells; ErbB Receptors; Interleukin-13; Ligands; Mice; Quinazolines; Trachea; Tyrphostins | 2011 |
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Head and Neck Neoplasms; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Quinazolines; Signal Transduction; Sirolimus; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Tyrphostins | 2011 |
Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1.
Topics: Animals; Cell Line; ErbB Receptors; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin-Secreting Cells; Isoquinolines; Naphthalenes; Oncogene Protein v-akt; Organophosphonates; Phosphorylation; Quinazolines; Rats; Receptor Cross-Talk; Receptors, AMPA; Tetrazoles; Tyrphostins | 2011 |
Effect of bisphenol A on the EGFR-STAT3 pathway in MCF-7 breast cancer cells.
Topics: Benzhydryl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Phenols; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Time Factors; Tyrphostins | 2012 |
Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells.
Topics: ADAM Proteins; ADAM17 Protein; Antibodies, Neutralizing; Cell Line; Epithelial Cells; ErbB Receptors; Gene Transfer Techniques; Genetic Vectors; Humans; Inflammation; Interleukin-8; Lentivirus; Lipopolysaccharides; Lung; Phosphorylation; Quinazolines; Respiratory Mucosa; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins | 2012 |
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.
Topics: Analysis of Variance; Animals; Blotting, Western; Bone Marrow Transplantation; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Flow Cytometry; Glomerulonephritis; Heparin-binding EGF-like Growth Factor; Humans; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Kidney Glomerulus; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Phosphorylation; Podocytes; Quinazolines; Real-Time Polymerase Chain Reaction; Renal Insufficiency; Statistics, Nonparametric; Tyrphostins | 2011 |
Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin.
Topics: Antiviral Agents; Cell Line; Ebolavirus; Genistein; Hemorrhagic Fever, Ebola; Humans; Lassa Fever; Lassa virus; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2012 |
EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Chromones; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Gene Expression; Gene Expression Profiling; Humans; Imidazoles; MAP Kinase Kinase 1; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation | 2012 |
EGFR is dispensable for c-Met-mediated proliferation and survival activities in mouse adult liver oval cells.
Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Deletion; Gene Expression; Heparin-binding EGF-like Growth Factor; Hepatocytes; Intercellular Signaling Peptides and Proteins; Liver; Mice; Mice, Knockout; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Quinazolines; Signal Transduction; Stem Cells; Transforming Growth Factor alpha; Tyrphostins | 2012 |
Effect of epidermal growth factor on follicle-stimulating hormone-induced proliferation of granulosa cells from chicken prehierarchical follicles.
Topics: Animals; Apoptosis; Cell Growth Processes; Chickens; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Granulosa Cells; In Situ Nick-End Labeling; Ovarian Follicle; Proliferating Cell Nuclear Antigen; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tyrphostins | 2011 |
Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway.
Topics: ADAM Proteins; ADAM12 Protein; Amino Acid Substitution; Animals; Arrestins; beta-Arrestins; Blotting, Western; Cell Line; Cell Proliferation; Dipeptides; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Microscopy, Confocal; Mutation; Phosphorylation; Quinazolines; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Transcriptional Activation; Tyrphostins | 2011 |
Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.
Topics: Animals; Anthracenes; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Survival; Docetaxel; Doxorubicin; Epirubicin; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Green Fluorescent Proteins; Humans; Mice; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine; Taxoids; Tyrphostins; Versicans | 2011 |
Ovarian expression and regulation of the stromelysins during the periovulatory period in the human and the rat.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Female; Granulosa Cells; Hormone Antagonists; Humans; Matrix Metalloproteinase 10; Matrix Metalloproteinase 11; Matrix Metalloproteinase 3; Mifepristone; Ovary; Ovulation; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Species Specificity; Theca Cells; Tyrphostins | 2012 |
p120-catenin modulates airway epithelial cell migration induced by cigarette smoke.
Topics: Adherens Junctions; Catenins; Cell Movement; Cells, Cultured; Delta Catenin; Epithelial Cells; ErbB Receptors; Gene Knockdown Techniques; Humans; Nicotiana; Protein Kinase Inhibitors; Quinazolines; Respiratory Mucosa; Smoke; Smoking; src-Family Kinases; Tyrphostins | 2012 |
What can and cannot be done using a microarray analysis? Treatment stratification and clinical applications in oncology.
Topics: Antineoplastic Agents; Butadienes; Early Growth Response Protein 1; ErbB Receptors; Gene Expression Profiling; Genes, Neoplasm; HEK293 Cells; Humans; Microarray Analysis; Molecular Targeted Therapy; Mutation; Neoplasms; Nitriles; Protein Kinase Inhibitors; Quinazolines; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Tyrphostins | 2011 |
Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer.
Topics: Benzamides; Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Disease-Free Survival; ErbB Receptors; Female; Humans; Interleukin-6; Neoplasms, Glandular and Epithelial; NF-kappa B; Ovarian Neoplasms; Plasminogen Activator Inhibitor 1; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Tumor Microenvironment; Tyrphostins | 2012 |
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.
Topics: Action Potentials; Animals; Biophysics; Caveolin 1; Cell Line, Transformed; Disease Models, Animal; Down-Regulation; Electric Stimulation; Epilepsy; ErbB Receptors; Female; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Kv1.1 Potassium Channel; Male; Mice; Mice, Transgenic; Neuregulin-1; Neurons; Parvalbumins; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Pilocarpine; Potassium Channel Blockers; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Signal Transduction; Tyrphostins | 2011 |
EGFR inhibitor enhances cisplatin sensitivity of human glioma cells.
Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Glioma; Humans; Protein Tyrosine Phosphatases; Quinazolines; Tyrphostins | 2011 |
Heparin-binding epidermal growth factor-like growth factor is a potent regulator of invasion activity in oral squamous cell carcinoma.
Topics: ADAM Proteins; ADAM17 Protein; Autocrine Communication; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Protease Inhibitors; Protein Kinase Inhibitors; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Time Factors; Tongue Neoplasms; Tyrphostins | 2012 |
EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Chromones; Cochlea; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Gene Expression Profiling; Green Fluorescent Proteins; Hair Cells, Auditory; Labyrinth Supporting Cells; Mice; Mice, 129 Strain; Mice, Knockout; Mice, Transgenic; Microscopy, Fluorescence; Morpholines; Organ Culture Techniques; Organ of Corti; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Nerve Growth Factor; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins | 2012 |
Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dietary Supplements; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Quinazolines; Random Allocation; Tumor Burden; Tyrphostins | 2012 |
ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.
Topics: Animals; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Doxorubicin; ErbB Receptors; Heart Ventricles; Mice; Myocytes, Cardiac; Protein Kinase Inhibitors; Quinazolines; Rats; Receptor, ErbB-4; Tumor Suppressor Protein p53; Tyrphostins | 2012 |
Angiotensin AT1 receptor blockers suppress oxidized low-density lipoprotein-derived formation of foam cells.
Topics: Acetyl-CoA C-Acetyltransferase; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Cholesterol Esters; Enzyme Inhibitors; ErbB Receptors; Foam Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Lipoproteins, LDL; Losartan; Macrophages; Quinazolines; Tetrazoles; Triglycerides; Tyrphostins | 2012 |
Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway.
Topics: Acetylcysteine; ADAM Proteins; ADAM17 Protein; Adult; Antigens, CD34; Asthma; Blood Cells; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Collagen Type I; ErbB Receptors; Female; Fibroblasts; Follow-Up Studies; Gefitinib; Humans; Hydrogen Peroxide; Leukocyte Common Antigens; Male; Middle Aged; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quinazolines; Respiratory Function Tests; Signal Transduction; Stem Cells; Tyrphostins | 2012 |
Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line; Cetuximab; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Multiple; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Morpholines; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Signal Transduction; Tyrphostins | 2012 |
Epidermal growth factor upregulates endometrial CYR61 expression via activation of the JAK2/STAT3 pathway.
Topics: Antineoplastic Agents; Cells, Cultured; Cysteine-Rich Protein 61; Drug Evaluation, Preclinical; Endometrium; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Humans; Janus Kinase 2; MAP Kinase Signaling System; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Up-Regulation | 2012 |
Simultaneous inhibition of EGFR and PI3K enhances radiosensitivity in human breast cancer.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chromones; ErbB Receptors; Female; G1 Phase; Humans; Mice; Mice, Nude; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents; Random Allocation; Resting Phase, Cell Cycle; Tyrphostins | 2012 |
Neutrophil gelatinase-associated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1.
Topics: Acetylation; Acute-Phase Proteins; Animals; Cell Line, Tumor; Cell Membrane; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Lipocalin-2; Lipocalins; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Nude; Models, Biological; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Quinazolines; Receptors, Progesterone; Transcription Factor RelA; Transcription, Genetic; Transplantation, Heterologous; Tyrphostins | 2012 |
Regulated intramembrane cleavage of the EGF receptor.
Topics: Amyloid Precursor Protein Secretases; Calpain; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Glycoproteins; HEK293 Cells; Humans; Ionomycin; Proteolysis; Quinazolines; Serine Endopeptidases; Serine Proteinase Inhibitors; Tyrphostins | 2012 |
Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Binding Sites; Butadienes; Cell Line, Tumor; Claudins; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protease Inhibitors; Protein Binding; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transcription Factor AP-1; Tyrphostins | 2012 |
Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells.
Topics: ADAM Proteins; ADAM17 Protein; Airway Remodeling; Autocrine Communication; Bronchi; Cell Line; Epithelial Cells; ErbB Receptors; Gene Silencing; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Particle Size; Particulate Matter; Quinazolines; RNA, Small Interfering; Tyrphostins | 2012 |
The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction.
Topics: Animals; Biomarkers; Calcium; Dinoprost; Echocardiography; Enzyme Inhibitors; ErbB Receptors; Glutathione; Male; Oxidative Stress; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Renal Tubular Transport, Inborn Errors; Superoxides; Tyrphostins | 2012 |
A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus.
Topics: Animals; Blotting, Western; Cholagogues and Choleretics; Diabetes Mellitus, Type 1; Endoplasmic Reticulum Stress; ErbB Receptors; Fibrosis; Gene Expression; Heart; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Myocardium; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Streptozocin; Taurochenodeoxycholic Acid; Transcription Factor CHOP; Tyrphostins; Vasodilation | 2012 |
Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts.
Topics: Acetophenones; Adult; Amino Acid Chloromethyl Ketones; Benzopyrans; Chemokine CCL2; Enzyme Inhibitors; ErbB Receptors; Humans; Middle Aged; Osteoblasts; Protein Kinase C; Pyrimidines; Quinazolines; Receptor, PAR-1; Signal Transduction; src-Family Kinases; Thrombin; Transcriptional Activation; Tyrphostins | 2012 |
Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Axons; Axotomy; Copper; Embryo, Nonmammalian; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Mutation; Nerve Degeneration; Nerve Regeneration; Neurons; Oligodeoxyribonucleotides, Antisense; Peripheral Nerves; Proto-Oncogene Proteins; Quinazolines; Schwann Cells; Trans-Activators; Transcription Factors; Tyrphostins; Zebrafish; Zebrafish Proteins | 2012 |
Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis.
Topics: Animals; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mutation; Protein Kinase Inhibitors; Quinazolines; rab GTP-Binding Proteins; rab5 GTP-Binding Proteins; Tyrphostins | 2012 |
Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.
Topics: Analysis of Variance; Blotting, Western; Cell Line, Tumor; Cell Movement; Cobra Cardiotoxin Proteins; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Metastasis; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins | 2012 |
Inhibition of phosphoinositide 3-kinase enhances the cytotoxicity of AG1478, an epidermal growth factor receptor inhibitor, in breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Flow Cytometry; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Tyrphostins | 2012 |
Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials.
Topics: Animals; Antineoplastic Agents; Azoxymethane; Colorectal Neoplasms; Diet; Disease Models, Animal; ErbB Receptors; Female; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Quinazolines; Sex Factors; Tyrphostins | 2012 |
The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells.
Topics: Autocrine Communication; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Inhibitory Concentration 50; Paclitaxel; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Tyrphostins | 2012 |
Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells.
Topics: Acetylcysteine; Angiotensin II; Animals; Arteriosclerosis; Cells, Cultured; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Indican; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tyrphostins; Up-Regulation | 2012 |
A novel epidermal growth factor-dependent extracellular signal-regulated MAP kinase cascade involved in sperm functionality in sheep.
Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Quinazolines; Sheep; Sperm Capacitation; Spermatozoa; Tissue Distribution; Tyrphostins | 2012 |
IL-1beta signals through the EGF receptor and activates Egr-1 through MMP-ADAM.
Topics: ADAM Proteins; Animals; Dipeptides; Early Growth Response Protein 1; ErbB Receptors; Humans; Interleukin-1beta; Matrix Metalloproteinases; Myocytes, Smooth Muscle; Quinazolines; Rats; Signal Transduction; Tyrphostins | 2012 |
Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury.
Topics: Animals; Animals, Newborn; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Inflammation; Male; MAP Kinase Signaling System; Microglia; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Spinal Cord Injuries; Tyrphostins | 2012 |
EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors.
Topics: Calcium; Carbachol; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; Maleimides; Protein Kinase C; Quinazolines; Quinolones; Receptors, Muscarinic; Ribosomal Protein S6 Kinases, 90-kDa; Tyrphostins | 2012 |
The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress.
Topics: Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2012 |
FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Gene Knockdown Techniques; Humans; Kaplan-Meier Estimate; Lapatinib; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-raf; Quinazolines; RNA Interference; Signal Transduction; Tyrphostins; Xenograft Model Antitumor Assays | 2012 |
Proteasome inhibition augments cigarette smoke-induced GM-CSF expression in trophoblast cells via the epidermal growth factor receptor.
Topics: Blotting, Western; Cell Line; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intercellular Signaling Peptides and Proteins; Leupeptins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 3; Nicotiana; Phosphorylation; Pregnancy; Proteasome Inhibitors; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smoke; Trophoblasts; Tyrphostins | 2012 |
An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs.
Topics: Animals; Antineoplastic Agents; Butadienes; Caenorhabditis elegans; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Humans; Models, Animal; Mutation; Neoplasms; Nitriles; Phenotype; Protein Structure, Tertiary; Quinazolines; Transgenes; Tyrphostins | 2012 |
The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells.
Topics: Blotting, Western; Cell Line; Epithelial Cells; ErbB Receptors; HT29 Cells; Humans; Immunoprecipitation; Interleukin-8; Intestines; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Receptor, ErbB-2; Tumor Necrosis Factor-alpha; Tyrphostins | 2012 |
Blockade of EGFR signaling promotes glioma stem-like cell invasiveness by abolishing ID3-mediated inhibition of p27(KIP1) and MMP3 expression.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Glioma; Humans; Inhibitor of Differentiation Proteins; Matrix Metalloproteinase 3; Mice; Neoplasm Proteins; Neoplastic Stem Cells; Quinazolines; Signal Transduction; Tyrphostins | 2013 |
Specific protein kinase C isoforms α and βI are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption.
Topics: Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation, Enzymologic; Isoenzymes; Meiosis; Mice; Oocytes; Ovarian Follicle; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger; Tyrphostins | 2012 |
Influence of epidermal growth factor receptor inhibitor AG1478 on epithelial-mesenchymal transition in endometrial carcinoma cells.
Topics: Carcinoma; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endometrial Neoplasms; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Quinazolines; Tumor Cells, Cultured; Tyrphostins | 2012 |
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.
Topics: Acute-Phase Proteins; Antibiotics, Antineoplastic; Benzylamines; Berberine; Biphenyl Compounds; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gene Expression; HT29 Cells; Humans; Lipocalin-2; Lipocalins; MCF-7 Cells; Nitrophenols; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Sirolimus; Sulfonamides; Tyrphostins | 2012 |
Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway.
Topics: Animals; Antigens, Ly; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Communication; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Imidazoles; Macrophages; Mammary Neoplasms, Animal; Membrane Proteins; Mice; Nanog Homeobox Protein; Neoplastic Stem Cells; Octamer Transcription Factor-3; Oleanolic Acid; Quinazolines; RNA, Small Interfering; Signal Transduction; SOXB1 Transcription Factors; STAT3 Transcription Factor; Tyrphostins | 2013 |
Migration of retinal pigment epithelial cells is EGFR/PI3K/AKT dependent.
Topics: Cell Growth Processes; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Retinal Pigment Epithelium; Retinaldehyde; Signal Transduction; Tyrphostins | 2013 |
ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53.
Topics: Antioxidants; Apoptosis; Benzothiazoles; Butadienes; Cell Line, Tumor; Cyclic N-Oxides; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Osteosarcoma; Phosphorylation; Piperazines; Protein Transport; Quinazolines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53; Tyrphostins | 2013 |
Evaluation of the coordinated actions of estrogen receptors with epidermal growth factor receptor and insulin-like growth factor receptor in the expression of cell surface heparan sulfate proteoglycans and cell motility in breast cancer cells.
Topics: Breast Neoplasms; Cell Movement; ErbB Receptors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation; Glypicans; Humans; Insulin-Like Growth Factor I; MCF-7 Cells; Quinazolines; Receptor Cross-Talk; Signal Transduction; Syndecan-2; Syndecan-4; Tyrphostins | 2013 |
TGF-α/HA complex promotes tympanic membrane keratinocyte migration and proliferation via ErbB1 receptor.
Topics: Cadherins; Cell Adhesion; Cell Migration Assays; Cell Movement; Cell Proliferation; Cells, Cultured; Epithelial Cells; ErbB Receptors; Humans; Hyaluronan Receptors; Hyaluronic Acid; Interleukins; Keratinocytes; Phenotype; Quinazolines; Transforming Growth Factor alpha; Tympanic Membrane; Tyrphostins; Vitronectin | 2013 |
Epidermal growth factor receptor tyrosine kinase inhibition up-regulates interleukin-6 in cancer cells and induces subsequent development of interstitial pneumonia.
Topics: Antibodies, Neutralizing; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Gefitinib; Humans; Interleukin-6; Lung Diseases, Interstitial; Neoplasms, Experimental; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins; Up-Regulation | 2013 |
γ-Secretase inhibition promotes fibrotic effects of albumin in proximal tubular epithelial cells.
Topics: Amyloid Precursor Protein Secretases; Animals; Benzodiazepinones; Cattle; Cell Line; Culture Media, Serum-Free; Endocytosis; Enzyme Inhibitors; ErbB Receptors; Fibronectins; Fibrosis; Humans; Kidney Tubules, Proximal; MAP Kinase Signaling System; Opossums; Proteolysis; Quinazolines; Serum Albumin, Bovine; Transforming Growth Factor beta1; Tyrphostins; Urothelium | 2013 |
The modulation of large airway smooth muscle phenotype and effects of epidermal growth factor receptor inhibition in the repeatedly allergen-challenged rat.
Topics: Airway Remodeling; Allergens; Amphiregulin; Animals; Bronchi; Bronchoalveolar Lavage Fluid; EGF Family of Proteins; ErbB Receptors; Gene Expression Regulation; Glycoproteins; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Methacholine Chloride; Muscle, Smooth; Myosin Heavy Chains; Ovalbumin; Quinazolines; Rats; Respiratory Hypersensitivity; Signal Transduction; Smooth Muscle Myosins; Tyrphostins | 2013 |
Time-dependent regulation of neuregulin-1β/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells.
Topics: Actins; Animals; Atrial Natriuretic Factor; Butadienes; Cell Differentiation; Cell Line; Embryoid Bodies; Embryonic Stem Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GATA4 Transcription Factor; Gene Expression Regulation, Developmental; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Mice; Myocytes, Cardiac; Myosin Light Chains; Neuregulin-1; Nitriles; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; T-Box Domain Proteins; Time Factors; Transcription Factors; Tyrphostins | 2013 |
G protein-coupled estrogen receptor1 (GPER1) may mediate Rho-kinase (ROCK-2) up-regulation in coronary endothelial cells.
Topics: Animals; Benzodioxoles; Cell Movement; Cells, Cultured; Coronary Circulation; Dactinomycin; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Estradiol; Estrogen Antagonists; Fulvestrant; Male; Nitric Oxide; Nitriles; Phenols; Progesterone; Protein Synthesis Inhibitors; Pyrazoles; Quinazolines; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; rho-Associated Kinases; Testosterone; Tyrphostins; Up-Regulation | 2013 |
Epidermal growth factor receptor transactivation by intracellular prostaglandin E2-activated prostaglandin E2 receptors. Role in retinoic acid receptor-β up-regulation.
Topics: Cell Line, Tumor; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Keratolytic Agents; Kidney Tubules, Proximal; Phosphorylation; Quinazolines; Receptors, Prostaglandin E; Receptors, Retinoic Acid; Transcriptional Activation; Tretinoin; Tyrphostins; Up-Regulation; Vascular Endothelial Growth Factor A | 2013 |
Sustained ERK [corrected] inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Count; Cell Line, Tumor; Cell Survival; Cetuximab; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Molecular Targeted Therapy; Neoadjuvant Therapy; Photochemotherapy; Photosensitizing Agents; Porphyrins; Quinazolines; Signal Transduction; Tyrphostins | 2013 |
Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines.
Topics: Blotting, Western; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Humans; Mucin-1; Pancreatic Neoplasms; Quinazolines; Rosiglitazone; Thiazolidinediones; Tyrphostins; Uterine Neoplasms | 2013 |
TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR.
Topics: Cells, Cultured; Colon; Cyclooxygenase 2; Drug Synergism; ErbB Receptors; Humans; Indoles; Lysophospholipids; Matrix Metalloproteinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myofibroblasts; Phosphorylation; Quinazolines; Receptors, G-Protein-Coupled; Signal Transduction; src-Family Kinases; Sulfonamides; Transcriptional Activation; Tumor Necrosis Factor-alpha; Tyrphostins; Up-Regulation | 2013 |
Profiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology.
Topics: Binding Sites; ErbB Receptors; Fluorescence Resonance Energy Transfer; GRB2 Adaptor Protein; HEK293 Cells; Humans; Kinetics; Protein Binding; Protein Interaction Domains and Motifs; Protein Multimerization; Quinazolines; Receptor, ErbB-3; Signal Transduction; Tyrphostins | 2013 |
Co-inhibition of epidermal growth factor receptor and insulin-like growth factor receptor 1 enhances radiosensitivity in human breast cancer cells.
Topics: Analysis of Variance; Animals; Apoptosis; Breast Neoplasms; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; G1 Phase Cell Cycle Checkpoints; Humans; MAP Kinase Signaling System; MCF-7 Cells; Mice; Mice, Nude; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Radiation Tolerance; Receptor, IGF Type 1; Tumor Stem Cell Assay; Tyrphostins | 2013 |
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.
Topics: Antineoplastic Agents; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; beta-Cyclodextrins; Cholagogues and Choleretics; Cyclic AMP; Deoxycholic Acid; Endocytosis; Endosomes; Enzyme Inhibitors; ErbB Receptors; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 5; HEK293 Cells; Humans; Membrane Microdomains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oleanolic Acid; Phenylalanine; Protein Transport; Quinazolines; Receptors, G-Protein-Coupled; Thiophenes; Tyrphostins | 2013 |
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.
Topics: Animals; Benzothiazoles; Connective Tissue Growth Factor; Endothelium, Vascular; ErbB Receptors; Fibroblasts; Fibrosis; Gene Expression Regulation; Isoquinolines; Mice; Mink; Myocytes, Smooth Muscle; Pyridines; Pyrroles; Quinazolines; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Serpin E2; Signal Transduction; Smad2 Protein; Smad3 Protein; Toluene; Transforming Growth Factor beta1; Tumor Suppressor Protein p53; Tyrphostins | 2013 |
[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Melanoma; Morpholines; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins | 2013 |
[EGFR-ERK signaling pathway down-regulates miRNA-145 in lung cancer cells].
Topics: Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Quinazolines; Tyrphostins | 2013 |
RANTES expression induced by Toll-like receptor 4 ligand in rat airway smooth muscle cells.
Topics: Animals; Asthma; Cell Culture Techniques; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Chromones; Dipeptides; ErbB Receptors; Lipopolysaccharides; Male; Matrix Metalloproteinase Inhibitors; Morpholines; Myocytes, Smooth Muscle; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Rats, Inbred BN; Signal Transduction; Toll-Like Receptor 4; Trachea; Transcriptional Activation; Tyrphostins | 2010 |
Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Neutralizing; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Diphtheria Toxin; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Quinazolines; Receptor, ErbB-4; RNA, Messenger; Thyroid Neoplasms; Tyrphostins | 2013 |
In brown adipocytes, adrenergically induced β₁-/β₃-(Gs)-, α₂-(Gi)- and α₁-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation.
Topics: Adipocytes, Brown; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Antagonists; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Animals; Clonidine; Dioxoles; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Imidazoles; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Norepinephrine; Phosphorylation; Quinazolines; Receptors, Adrenergic; Tyrphostins | 2013 |
Oxidative DNA damage and mammary cell proliferation by alcohol-derived salsolinol.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Cell Line; Cell Proliferation; Coordination Complexes; Deoxyguanosine; DNA Damage; ErbB Receptors; Estrogen Receptor alpha; Ethanol; Female; Humans; Hydrogen Peroxide; Iron; Isoquinolines; Mammary Glands, Human; MCF-7 Cells; Oxidative Stress; Quinazolines; Transition Elements; Tyrphostins | 2013 |
Combination of the EGFR tyrosine kinase inhibitor AG1478 and 5-FU: no synergistic effect on EGFR phosphorylation, cell proliferation and apoptosis induction.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Flow Cytometry; Fluorescence Resonance Energy Transfer; Fluorouracil; Humans; Phosphorylation; Quinazolines; Tyrphostins | 2013 |
Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Progression; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gemcitabine; Gene Knockdown Techniques; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; RNA, Small Interfering; STAT3 Transcription Factor; Tyrphostins; Xenograft Model Antitumor Assays | 2013 |
Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal growth factor receptor in rat granulosa cells.
Topics: Animals; Butadienes; Cells, Cultured; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Granulosa Cells; Hydrocarbons, Brominated; MAP Kinase Signaling System; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar; Receptors, LH; Toxicity Tests; Tyrphostins | 2014 |
Pb²⁺ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells.
Topics: Cell Line, Tumor; Environmental Pollutants; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Interleukin-8; Lead; Proto-Oncogene Proteins c-jun; Quinazolines; Stomach Neoplasms; Transcription Factor AP-1; Tyrphostins; Up-Regulation | 2015 |
Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.
Topics: Acetophenones; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Female; Humans; NADPH Oxidases; NF-kappa B; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Sesquiterpenes; Superoxides; Tyrphostins | 2013 |
Spatial intensity distribution analysis (SpIDA): a new tool for receptor tyrosine kinase activation and transactivation quantification.
Topics: Apomorphine; Cell Line; ErbB Receptors; Fluorescent Antibody Technique; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Ligands; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Imaging; Neurons; Protein Multimerization; Quinazolines; Receptor, trkB; Receptors, Dopamine; Recombinant Fusion Proteins; Software; Transcriptional Activation; Tyrphostins | 2013 |
Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; ErbB Receptors; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Profiling; Insulin Resistance; Insulin-Secreting Cells; Male; Quinazolines; Rats; Rats, Wistar; Signal Transduction; TOR Serine-Threonine Kinases; Tyrphostins | 2014 |
Tissue kallikrein mediates neurite outgrowth through epidermal growth factor receptor and flotillin-2 pathway in vitro.
Topics: Animals; Cells, Cultured; ErbB Receptors; Humans; Membrane Proteins; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Neurons; Phosphorylation; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Tissue Kallikreins; Tyrphostins | 2014 |
GnRH-(1-5) transactivates EGFR in Ishikawa human endometrial cells via an orphan G protein-coupled receptor.
Topics: Calcium Signaling; Cell Line, Tumor; Cell Movement; Endometrial Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Gonadotropin-Releasing Hormone; Humans; Matrix Metalloproteinase Inhibitors; Oligopeptides; Oncogene Proteins; Peptide Fragments; Phenylalanine; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; Quinazolines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, LHRH; Thiophenes; Transcriptional Activation; Tyrphostins | 2014 |
Transcriptional regulation of Δ6-desaturase by peroxisome proliferative-activated receptor δ agonist in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
Topics: Cell Line, Tumor; ErbB Receptors; Fatty Acid Desaturases; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Pancreatic Neoplasms; PPAR delta; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thiazoles; Tyrphostins | 2013 |
[Effects of AG1478 on the expression of FOXM1 gene via FOXO3a in non-small cell lung cancer cells].
Topics: Adenocarcinoma; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; ErbB Receptors; Forkhead Box Protein M1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Lung Neoplasms; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transfection; Tyrphostins | 2013 |
Effect of NRG-1/ErbB signaling intervention on the differentiation of bone marrow stromal cells into sinus node-like cells.
Topics: Action Potentials; Animals; Bone Marrow Cells; Cell Differentiation; ErbB Receptors; Neuregulin-1; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sinoatrial Node; Stromal Cells; Tyrphostins | 2014 |
Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis.
Topics: Adolescent; Adult; Aged; Animals; Cell Line; Colitis; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Cytokines; Dextran Sulfate; ErbB Receptors; Female; Gene Expression Regulation; Humans; Immunity, Innate; Inflammation; Interferon-gamma; Interleukin-10; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Middle Aged; Myeloid Cells; Neutrophils; NF-kappa B; Quinazolines; Regeneration; Signal Transduction; Spleen; Tumor Necrosis Factor-alpha; Tyrphostins; Young Adult | 2014 |
Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells.
Topics: Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Neoplasms; Nitro Compounds; Oxadiazoles; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins | 2014 |
Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Line, Tumor; Cetuximab; Colonic Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Heterografts; Humans; Mice, Inbred BALB C; Quinazolines; Receptor-Like Protein Tyrosine Phosphatases, Class 2; STAT3 Transcription Factor; Tyrphostins | 2014 |
4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts.
Topics: Adult; Aging; Aldehydes; Animals; Aorta; Cell Line, Transformed; Elastin; ErbB Receptors; Fibroblasts; Flavonoids; Gene Expression Regulation; Homeodomain Proteins; Humans; Lipid Peroxidation; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Primary Cell Culture; Protein Transport; Quinazolines; Repressor Proteins; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Tyrphostins | 2014 |
β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt.
Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Apoptosis; Caspase 3; Cats; ErbB Receptors; Gene Expression Regulation; Isoproterenol; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Phosphorylation; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Signal Transduction; Tyrphostins | 2014 |
The epidermal growth factor receptor is a regulator of epidermal complement component expression and complement activation.
Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Complement Activation; Complement System Proteins; Epidermal Cells; Epidermis; ErbB Receptors; Gene Expression; Humans; Keratinocytes; Mice; Microscopy, Fluorescence; Oligonucleotide Array Sequence Analysis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Skin; Transcriptome; Transforming Growth Factor alpha; Tyrphostins | 2014 |
Early development of a celiac trunk aneurysm during anti-vascular endothelial growth factor receptor therapy.
Topics: Aged; Aneurysm; Celiac Artery; Enzyme Inhibitors; Female; Humans; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Thyroid Neoplasms; Tomography, X-Ray Computed; Treatment Outcome; Tyrphostins; Withholding Treatment | 2014 |
Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells.
Topics: Adenosine Triphosphate; Autocrine Communication; Cell Line, Tumor; Cell Movement; Humans; Lung Neoplasms; Quinazolines; Receptors, Purinergic P2X7; Tyrphostins | 2014 |
Quantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substances.
Topics: Coated Pits, Cell-Membrane; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; HeLa Cells; Humans; Microscopy, Fluorescence; Quinazolines; Tyrphostins | 2014 |
Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; ErbB Receptors; Female; HSP90 Heat-Shock Proteins; Humans; Male; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Minor Histocompatibility Antigens; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Quinazolines; Transplantation, Heterologous; Tyrphostins | 2014 |
Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways.
Topics: Animals; Arrestins; beta-Arrestin 1; beta-Arrestins; Cell Line; Cell Proliferation; Dipeptides; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Matrix Metalloproteinases; Mutation; Myoblasts, Cardiac; Phenylephrine; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins | 2014 |
MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma.
Topics: Blotting, Western; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Matrix Metalloproteinase 9; MicroRNAs; Models, Genetic; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins | 2014 |
Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; ErbB Receptors; Humans; Lipids; Liver; Liver Neoplasms; Nanostructures; Quinazolines; Tyrphostins | 2014 |
Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Immunohistochemistry; Mice; Mice, Nude; Ovarian Neoplasms; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Quinazolines; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles; Tyrphostins; Xenograft Model Antitumor Assays | 2014 |
The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-α-EGFR pathway.
Topics: ADAM Proteins; ADAM17 Protein; Antimicrobial Cationic Peptides; Cathelicidins; Cell Line; Epithelial Cells; ErbB Receptors; Humans; Mucin 5AC; Quinazolines; Respiratory Mucosa; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins | 2014 |
Epidermal growth factor receptor is required for estradiol-stimulated bovine satellite cell proliferation.
Topics: Animals; Cattle; Cell Proliferation; Cells, Cultured; ErbB Receptors; Estradiol; Gene Silencing; Insulin-Like Growth Factor I; Quinazolines; Receptor, IGF Type 1; Satellite Cells, Skeletal Muscle; Tyrphostins | 2014 |
Immediate and long-term consequences of vascular toxicity during zebrafish development.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Blood Vessels; Embryo, Nonmammalian; Embryonic Development; ErbB Receptors; Phthalazines; Protein Kinase Inhibitors; Pyridines; Quinazolines; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2; Zebrafish | 2014 |
An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction.
Topics: Animals; Biological Assay; Cell Communication; Cell Line, Tumor; Cell Movement; Coculture Techniques; Collagen Type I; Epidermal Growth Factor; Extracellular Matrix; Female; Fibronectins; Gefitinib; Humans; Macrophages; Mammary Glands, Human; Mice; Molecular Imaging; Quinazolines; Signal Transduction; Time-Lapse Imaging; Tyrphostins | 2014 |
Resistance of oral squamous cell carcinoma cells to cetuximab is associated with EGFR insensitivity and enhanced stem cell-like potency.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cetuximab; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Mouth Neoplasms; Phosphorylation; Quinazolines; Stem Cells; Tumor Microenvironment; Tyrphostins | 2014 |
Epidermal growth factor-like domain-containing protein 7 (EGFL7) enhances EGF receptor-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Animals; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; EGF Family of Proteins; Endothelial Growth Factors; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Transplantation; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Small Interfering; Signal Transduction; Snail Family Transcription Factors; Stomach Neoplasms; Transcription Factors; Tyrphostins; Vimentin | 2014 |
Antagonism of the prostaglandin E2 EP1 receptor in MDCK cells increases growth through activation of Akt and the epidermal growth factor receptor.
Topics: Animals; Bridged Bicyclo Compounds; Caproates; Cell Proliferation; Dogs; ErbB Receptors; Heterocyclic Compounds, 3-Ring; Hydrazines; Ibuprofen; Kidney; Madin Darby Canine Kidney Cells; Oxazepines; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Tyrphostins | 2014 |
Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: involvement of MMP-2.
Topics: Acrylamides; Animals; Cell Proliferation; Cells, Cultured; ErbB Receptors; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Quinazolines; Rats, Wistar; Signal Transduction; Thrombin; Tyrphostins | 2014 |
TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
Topics: Animals; Antibodies, Neutralizing; Carbazoles; Cerebral Cortex; Enzyme Inhibitors; Female; Humans; Indole Alkaloids; Mice; Mice, Knockout; Neuregulin-1; Neurons; Phospholipase C gamma; Phosphorylation; Quinazolines; Receptor, ErbB-4; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction; Synapses; Tyrphostins | 2014 |
Protease-mediated human smooth muscle cell proliferation by urokinase requires epidermal growth factor receptor transactivation by triple membrane signaling.
Topics: ADAM Proteins; ADAM10 Protein; ADAM12 Protein; Amyloid Precursor Protein Secretases; Cell Proliferation; Cells, Cultured; Coronary Vessels; Enzyme Inhibitors; ErbB Receptors; Humans; Membrane Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Protein Structure, Tertiary; Quinazolines; Receptors, Urokinase Plasminogen Activator; RNA, Small Interfering; Signal Transduction; Tyrphostins; Urokinase-Type Plasminogen Activator | 2014 |
Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.
Topics: Cadmium Chloride; Calcium-Binding Proteins; Cell Line; Chromones; Down-Regulation; Epithelial Cells; ErbB Receptors; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Jagged-2 Protein; Kidney Tubules, Proximal; Maleimides; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Receptor, Notch1; RNA Interference; RNA, Small Interfering; Serrate-Jagged Proteins; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Tumor Suppressor Protein p53; Tyrphostins | 2014 |
Induction of fibronectin in response to epidermal growth factor is suppressed by silibinin through the inhibition of STAT3 in triple negative breast cancer cells.
Topics: Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Female; Fibronectins; Gefitinib; Humans; MCF-7 Cells; Phosphorylation; Quinazolines; Signal Transduction; Silybin; Silymarin; Triple Negative Breast Neoplasms; Tyrphostins | 2014 |
Epidermal growth factor receptor activity is necessary for mouse basal cell proliferation.
Topics: Animals; Benzothiazoles; Cell Proliferation; Enzyme Inhibitors; Female; Humans; Male; Mice; Mice, Transgenic; Naphthalenes; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-2; src-Family Kinases; Stem Cells; Trachea; Tyrphostins | 2014 |
EGFR-AKT-mTOR activation mediates epiregulin-induced pleiotropic functions in cultured osteoblasts.
Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Blotting, Western; Carrier Proteins; Cell Death; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Epiregulin; ErbB Receptors; MAP Kinase Signaling System; Mice; Osteoblasts; Proto-Oncogene Proteins c-akt; Quinazolines; RNA Interference; TOR Serine-Threonine Kinases; Tyrphostins | 2015 |
Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors.
Topics: Amygdala; Animals; Anxiety; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Feeding Behavior; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; GPI-Linked Proteins; In Vitro Techniques; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Proteins; Nogo Receptor 1; Pyrimidines; Quinazolines; Reaction Time; Receptor, ErbB-4; Receptors, Cell Surface; Signal Transduction; Tyrphostins | 2015 |
Non-genomic actions of estradiol and 4-OH-tamoxifen on murine breast cancer cells.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Humans; MCF-7 Cells; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tamoxifen; Tyrphostins | 2015 |
Epidermal growth factor-network signaling mediates luteinizing hormone regulation of BNP and CNP and their receptor NPR2 during porcine oocyte meiotic resumption.
Topics: Amphiregulin; Animals; Cyclic GMP; DNA Primers; Female; Granulosa Cells; In Situ Hybridization; Luteinizing Hormone; Meiosis; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Oocytes; Quinazolines; Radioimmunoassay; Real-Time Polymerase Chain Reaction; Receptors, Atrial Natriuretic Factor; Signal Transduction; Swine; Tyrphostins | 2014 |
Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation.
Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromones; DNA; Dose-Response Relationship, Drug; Flavonoids; Hepatocytes; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Male; MAP Kinase Signaling System; Morpholines; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tyrphostins | 2014 |
Inhibition of progression of PanIN through antagonizing EGFR.
Topics: Animals; Antineoplastic Agents; Carcinoma in Situ; Disease Progression; Drug Screening Assays, Antitumor; ErbB Receptors; Male; Mice, Transgenic; Pancreas; Pancreatic Neoplasms; Quinazolines; Tyrphostins | 2015 |
Co-targeting EGFR and Autophagy Impairs Ovarian Cancer Cell Survival during Detachment from the ECM.
Topics: Animals; Antineoplastic Agents; Autophagy; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix; Female; Humans; Mice, SCID; Molecular Targeted Therapy; Ovarian Neoplasms; Peritoneal Neoplasms; Quinazolines; Spheroids, Cellular; Tumor Cells, Cultured; Tyrphostins; Xenograft Model Antitumor Assays | 2015 |
Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface.
Topics: Animals; Cell Line, Tumor; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cystine; Endoplasmic Reticulum; ErbB Receptors; Humans; Mice, Inbred C57BL; Mice, Transgenic; Mucoproteins; Oncogene Proteins; Protein Kinase Inhibitors; Protein Transport; Proteins; Quinazolines; Signal Transduction; Thioredoxins; Tyrphostins | 2015 |
A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Apoptosis; Cell Proliferation; Cell Survival; ErbB Receptors; Humans; Mice; Microglia; Neurons; Quinazolines; Signal Transduction; Spinal Cord Injuries; Tyrphostins | 2015 |
EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Line; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; ErbB Receptors; Fibrosis; Male; Mice; Myocardium; Oxidative Stress; Proto-Oncogene Proteins c-akt; Quinazolines; Reactive Oxygen Species; Signal Transduction; Tyrphostins; Ventricular Remodeling | 2015 |
EGFR participates downstream of ERα in estradiol-17β-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets.
Topics: Animals; ATP-Binding Cassette Transporters; Bile Canaliculi; Cells, Cultured; Cholestasis; ErbB Receptors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Antagonists; Female; Fulvestrant; Gene Knockdown Techniques; Hepatocytes; Quinazolines; Rats; Rats, Wistar; src-Family Kinases; Tyrphostins | 2016 |
Neuregulin 1 Type II-ErbB Signaling Promotes Cell Divisions Generating Neurons from Neural Progenitor Cells in the Developing Zebrafish Brain.
Topics: Animals; Brain; Cell Division; ErbB Receptors; Gene Expression Regulation, Developmental; Neural Stem Cells; Neuregulin-1; Neurogenesis; Neurons; Quinazolines; Signal Transduction; Tyrphostins; Zebrafish | 2015 |
The Soluble Heparin-Binding EGF-Like Growth Factor Stimulates EGF Receptor Trafficking to the Nucleus.
Topics: Cell Line; Cell Nucleus; Cyclin D1; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Ligands; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Protein Transport; Quinazolines; Tyrphostins | 2015 |
Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cytochrome b Group; Diabetes Mellitus, Type 2; Diabetic Angiopathies; ErbB Receptors; Mice; Mice, Knockout; NADPH Oxidase 4; NADPH Oxidases; Phenylephrine; Quinazolines; Tyrphostins; Vasoconstriction; Vasodilation | 2015 |
Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model.
Topics: Adolescent; Air; Asthma; Bronchi; Cell Count; Cell Differentiation; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Electric Impedance; Epidermal Growth Factor; Female; Goblet Cells; Humans; Infant; Male; Models, Biological; Mucin 5AC; Quinazolines; RNA, Messenger; Tyrphostins | 2015 |
t-Darpp Promotes Enhanced EGFR Activation and New Drug Synergies in Her2-Positive Breast Cancer Cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Dopamine and cAMP-Regulated Phosphoprotein 32; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Humans; Quinazolines; Receptor, ErbB-2; Trastuzumab; Tyrphostins | 2015 |
The Sbi Protein Contributes to Staphylococcus aureus Inflammatory Response during Systemic Infection.
Topics: Animals; Bacterial Proteins; Binding Sites, Antibody; Carrier Proteins; Chemokine CXCL1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Imidazoles; Immunoglobulin G; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neutrophil Infiltration; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Staphylococcal Infections; Staphylococcal Protein A; Staphylococcus aureus; Tyrphostins; Virulence Factors | 2015 |
Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.
Topics: Animals; Benzoxazines; Cartilage, Articular; Chemokine CCL2; Disease Models, Animal; Disease Progression; Male; Osteoarthritis; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiro Compounds; Transforming Growth Factor alpha; Tyrphostins; Up-Regulation; Wounds and Injuries | 2015 |
Rapidly activated epidermal growth factor receptor mediates lipopolysaccharide-triggered migration of microglia.
Topics: Animals; Cell Movement; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Microglia; Phosphorylation; Quinazolines; Rats, Wistar; Tyrphostins | 2015 |
Modulatory Effects of Curcumin and Tyrphostins (AG494 and AG1478) on Growth Regulation and Viability of LN229 Human Brain Cancer Cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; DNA Damage; ErbB Receptors; Humans; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Tyrphostins | 2015 |
HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling.
Topics: Anoikis; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Adhesion; Cell Aggregation; Cell Line, Tumor; Chlorobenzoates; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Female; Focal Adhesion Kinase 1; Humans; Integrin beta1; Paxillin; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; src-Family Kinases; Styrenes; Tyrphostins | 2015 |
Zinc pyrithione inhibits caspase-3 activity, promotes ErbB1-ErbB2 heterodimerization and suppresses ErbB2 downregulation in cardiomyocytes subjected to ischemia/reperfusion.
Topics: Amino Acid Chloromethyl Ketones; Animals; Benzothiazoles; Cardiotonic Agents; Caspase 3; Caspase Inhibitors; Cell Hypoxia; Chlorides; Down-Regulation; ErbB Receptors; Lapatinib; Leupeptins; Myocytes, Cardiac; Organometallic Compounds; Phosphorylation; Proteasome Inhibitors; Protein Kinase Inhibitors; Protein Multimerization; Pyridines; Quinazolines; Rats; Receptor, ErbB-2; RNA, Messenger; Thiones; Tyrphostins; Zinc Compounds | 2015 |
Role of G protein-coupled receptors (GPCR), matrix metalloproteinases 2 and 9 (MMP2 and MMP9), heparin-binding epidermal growth factor-like growth factor (hbEGF), epidermal growth factor receptor (EGFR), erbB2, and insulin-like growth factor 1 receptor (I
Topics: Androgens; Animals; Cattle; Cell Proliferation; Cells, Cultured; Estradiol; Estrogens; Gene Expression Regulation; Genes, erbB-2; Heparin; Heparin-binding EGF-like Growth Factor; Insulin-Like Growth Factor I; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Quinazolines; Receptor, IGF Type 1; Receptors, G-Protein-Coupled; Satellite Cells, Skeletal Muscle; Trenbolone Acetate; Tyrphostins | 2015 |
The P2RY2 Receptor Induces Carcinoma Cell Migration and EMT Through Cross-Talk With Epidermal Growth Factor Receptor.
Topics: Androstadienes; Cadherins; Cell Line, Tumor; Cell Movement; Epithelial Cells; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovary; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor Cross-Talk; Receptors, Purinergic P2Y2; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Tyrphostins; Uridine Triphosphate; Vimentin; Wortmannin | 2016 |
Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS.
Topics: Animals; Axons; Biotin; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Dextrans; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Male; Mutation; Myelin Basic Protein; Neurons; Phosphorylation; Protein Phosphatase 2; Quinazolines; Rats; Rats, Sprague-Dawley; Recovery of Function; Sphingosine; Spinal Cord Injuries; Tyrphostins | 2015 |
[Research of the influence and mechanism about metformin on the proliferation of differentiated endometrial carcinoma cells].
Topics: Antineoplastic Agents; Cell Differentiation; Cell Proliferation; Down-Regulation; Endometrial Neoplasms; Endometrium; Female; Humans; Hypoglycemic Agents; Metformin; Mitogen-Activated Protein Kinase 3; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins | 2015 |
Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells.
Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gene Deletion; Gene Expression; Gene Knockout Techniques; Humans; Integrin beta1; Protein Kinase Inhibitors; Protein Subunits; Quinazolines; Signal Transduction; Tyrphostins | 2016 |
Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiotonic Agents; Cell Line; Drug Evaluation, Preclinical; Epidermal Growth Factor; ErbB Receptors; Gene Knockdown Techniques; Mice, Inbred C57BL; Myocytes, Cardiac; Quinazolines; Rats; Tyrphostins | 2016 |
Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chelating Agents; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Proteolipid Protein; Oligodendroglia; Peptide Fragments; Proteoglycans; Quinazolines; Stem Cells; Thymosin; Time Factors; Tyrphostins | 2016 |
Exercise training activates neuregulin 1/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model.
Topics: Animals; Disease Models, Animal; Male; Myocardial Infarction; Neuregulin-1; Oncogene Proteins v-erbB; Physical Conditioning, Animal; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins | 2016 |
Inhibitory effect of luteolin on the proliferation of human breast cancer cell lines induced by epidermal growth factor.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Luteolin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Quinazolines; Tyrphostins | 2016 |
Epidermal Growth Factor Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells.
Topics: Benzamides; Breast; Cell Line; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Drug Synergism; Epithelial Cells; ErbB Receptors; Gefitinib; Humans; MAP Kinase Kinase 1; Morpholines; Polychlorinated Dibenzodioxins; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger; Tyrphostins | 2016 |
Inhibition of the Ras-ERK pathway in mitotic COS7 cells is due to the inability of EGFR/Raf to transduce EGF signaling to downstream proteins.
Topics: Animals; Caveolins; Cell Line; Chlorocebus aethiops; Clathrin; COS Cells; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; MAP Kinase Signaling System; Nocodazole; Phosphorylation; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Quinazolines; raf Kinases; Shc Signaling Adaptor Proteins; Tetradecanoylphorbol Acetate; Tyrphostins | 2016 |
EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation.
Topics: Animals; Cell Line; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; ErbB Receptors; Hyperlipidemias; Immunoblotting; Inflammation; Kidney; Male; Mice, Inbred C57BL; Mice, Knockout; Obesity; Oxidative Stress; Phosphorylation; Quinazolines; Rats; RNA Interference; src-Family Kinases; Tyrphostins | 2016 |
Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney.
Topics: Animals; Blood Glucose; Cyclic N-Oxides; Dendrimers; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; ErbB Receptors; Kidney; Male; MAP Kinase Signaling System; Phosphorylation; Quinazolines; Rats; Spin Labels; Tyrphostins | 2016 |
Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Resistance, Neoplasm; Drug Therapy, Combination; ErbB Receptors; Humans; Quinazolines; RNA, Small Interfering; Transcriptome; Tyrphostins | 2016 |
Regulation of Viral Infection-induced Airway Remodeling Cytokine Production by the TLR3-EGFR Signaling Pathway in Human Bronchial Epithelial Cells.
Topics: Airway Remodeling; Antiviral Agents; Bronchi; Cells, Cultured; Cytokines; ErbB Receptors; Flavonoids; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mucin 5AC; p38 Mitogen-Activated Protein Kinases; Poly I-C; Protein Kinase Inhibitors; Quinazolines; Respiratory Mucosa; RNA, Messenger; Toll-Like Receptor 3; Transforming Growth Factor beta1; Tyrphostins; Vascular Endothelial Growth Factor A; Virus Diseases | 2016 |
Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats.
Topics: Animals; Cerebral Arteries; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Male; Models, Animal; Quinazolines; Random Allocation; Rats, Sprague-Dawley; Recombinant Proteins; Tenascin; Tyrphostins; Vasoconstriction; Vasospasm, Intracranial | 2016 |
EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice.
Topics: Animals; Apolipoproteins E; Apoptosis; Cardiovascular Diseases; Cell Line; Diet, High-Fat; ErbB Receptors; Hyperlipidemias; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Palmitic Acid; Protein Kinase Inhibitors; Quinazolines; Rats; src-Family Kinases; Toll-Like Receptor 4; Tyrphostins | 2016 |
UV-Vis spectroscopy and solvatochromism of the tyrosine kinase inhibitor AG-1478.
Topics: Hydrogen Bonding; Protein Kinase Inhibitors; Quinazolines; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tyrphostins | 2016 |
ADAM17-siRNA inhibits MCF-7 breast cancer through EGFR-PI3K-AKT activation.
Topics: ADAM17 Protein; Animals; Benzamides; Breast Neoplasms; Chromones; Diphenylamine; ErbB Receptors; Female; Humans; MCF-7 Cells; Mice; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Small Interfering; Signal Transduction; Tyrphostins; Xenograft Model Antitumor Assays | 2016 |
Phytanic acid activates NADPH oxidase through transactivation of epidermal growth factor receptor in vascular smooth muscle cells.
Topics: Animals; Aorta; Cattle; Cell Separation; Culture Media; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Phosphoproteins; Phosphorylation; Phytanic Acid; Primary Cell Culture; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Transcriptional Activation; Tyrphostins | 2016 |
Nitric Oxide and ERK mediates regulation of cellular processes by Ecdysterone.
Topics: 3T3-L1 Cells; Aizoaceae; Animals; Cell Migration Assays; Cell Movement; Cell Proliferation; Ecdysterone; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Mice; Nitric Oxide; Quinazolines; Signal Transduction; Tyrphostins | 2016 |
Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.
Topics: 1-Phosphatidylinositol 4-Kinase; Antiviral Agents; Dose-Response Relationship, Drug; Encephalomyocarditis virus; Enzyme Inhibitors; HeLa Cells; Hepacivirus; Humans; Molecular Targeted Therapy; Mutation; Quinazolines; Tyrphostins; Virus Replication | 2016 |
New EGFR inhibitor, 453, prevents renal fibrosis in angiotensin II-stimulated mice.
Topics: Angiotensin II; Animals; Apoptosis; ErbB Receptors; Fibrosis; Kidney; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2016 |
The role of RNase 7 in innate cutaneous defense against Pseudomonas aeruginosa.
Topics: ADAM17 Protein; Antibodies, Neutralizing; Cells, Cultured; Cetuximab; Epidermis; ErbB Receptors; Gene Expression; Gene Silencing; Humans; Hydroxamic Acids; Keratinocytes; Organoids; Pseudomonas aeruginosa; Quinazolines; Ribonucleases; RNA, Small Interfering; Signal Transduction; Skin; Toll-Like Receptor 5; Tyrphostins | 2017 |
ADAM17 and EGFR regulate IL-6 receptor and amphiregulin mRNA expression and release in cigarette smoke-exposed primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD).
Topics: ADAM17 Protein; Aged; Airway Remodeling; Amphiregulin; Bronchi; Epithelial Cells; ErbB Receptors; Female; Humans; Inhalation Exposure; Male; Middle Aged; Nicotiana; Pulmonary Disease, Chronic Obstructive; Quinazolines; Receptors, Interleukin-6; RNA, Messenger; Signal Transduction; Smoking; Tyrphostins | 2016 |
EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis.
Topics: Amphiregulin; Animals; Brain; Cytokines; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Meningitis; Mice; Phosphorylation; Quinazolines; Receptor, ErbB-3; Signal Transduction; Streptococcal Infections; Streptococcus suis; Swine; Transcriptional Activation; Tyrosine; Tyrphostins | 2016 |
Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration.
Topics: Animals; Cell Proliferation; Ceruletide; ErbB Receptors; Female; Gene Dosage; Gene Expression Regulation; Hippo Signaling Pathway; Humans; Mice; Mice, Inbred C57BL; Mucoproteins; Oncogene Proteins; Pancreatitis; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Quinazolines; Regeneration; Signal Transduction; Tyrphostins | 2016 |
Blocking NOTCH pathway can enhance the effect of EGFR inhibitor through targeting CD133+ endometrial cancer cells.
Topics: AC133 Antigen; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Line, Tumor; Diamines; Drug Resistance, Neoplasm; Drug Synergism; Endometrial Neoplasms; ErbB Receptors; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Quinazolines; Receptors, Notch; Signal Transduction; Thiazoles; Tyrphostins; Xenograft Model Antitumor Assays | 2018 |
Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.
Topics: Amphiregulin; Antigens, CD; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease-Free Survival; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Ligands; Membrane Proteins; Neoplasm Invasiveness; Ovarian Neoplasms; Protein Binding; Quinazolines; RNA Interference; Signal Transduction; Snail Family Transcription Factors; Time Factors; Tyrphostins | 2016 |
Neuroinflammation-Induced Downregulation of Hippocampacal Neuregulin 1-ErbB4 Signaling in the Parvalbumin Interneurons Might Contribute to Cognitive Impairment in a Mouse Model of Sepsis-Associated Encephalopathy.
Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Down-Regulation; Encephalitis; Enzyme Inhibitors; Gamma Rhythm; Hippocampus; Interneurons; Mice; Neuregulin-1; Parvalbumins; Quinazolines; Receptor, ErbB-4; Sepsis-Associated Encephalopathy; Signal Transduction; Tyrphostins | 2017 |
Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Movement; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxyprostaglandin Dehydrogenases; MCF-7 Cells; Mice, Inbred BALB C; Mice, SCID; Multidrug Resistance-Associated Proteins; Neoplasm Metastasis; Organic Anion Transporters; Propionates; Quinazolines; Quinolines; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; Signal Transduction; Time Factors; Transfection; Triple Negative Breast Neoplasms; Tumor Microenvironment; Tyrphostins | 2017 |
Quantifying receptor trafficking and colocalization with confocal microscopy.
Topics: Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; HeLa Cells; Humans; Hydrazones; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Protein Transport; Quinazolines; rab5 GTP-Binding Proteins; Recombinant Fusion Proteins; Red Fluorescent Protein; Transformation, Genetic; Tyrphostins | 2017 |
Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Drug Synergism; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Head and Neck Neoplasms; Humans; Mutant Proteins; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Quinazolines; Rotenone; Squamous Cell Carcinoma of Head and Neck; Time Factors; Tyrphostins | 2017 |
Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells.
Topics: Arginase; Butadienes; Cell Count; Cell Hypoxia; Cell Proliferation; Cell Survival; Culture Media, Conditioned; Endothelial Cells; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Gene Silencing; Humans; Lung; Microvessels; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; RNA, Small Interfering; Tyrphostins | 2017 |
Effects of arachidonic acid on FFA4 receptor: Signaling, phosphorylation and internalization.
Topics: Arachidonic Acid; beta-Arrestins; Calcium; Cell Line; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Phosphorylation; Quinazolines; Receptors, G-Protein-Coupled; Signal Transduction; Tyrphostins | 2017 |
Inactivation of EGFR/AKT signaling enhances TSA-induced ovarian cancer cell differentiation.
Topics: Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins | 2017 |
EGFR inhibition attenuates diabetic nephropathy through decreasing ROS and endoplasmic reticulum stress.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endoplasmic Reticulum Stress; ErbB Receptors; Humans; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reactive Oxygen Species; Streptozocin; Transforming Growth Factor beta; Tyrphostins | 2017 |
Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cetuximab; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Indoles; Mouth Neoplasms; Phosphatidylinositol 3-Kinases; Piperazines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pseudopodia; Quinazolines; Signal Transduction; Sulfonamides; Tyrphostins | 2017 |
Inhibition of epidermal growth factor receptor attenuates LPS-induced inflammation and acute lung injury in rats.
Topics: Acute Lung Injury; Animals; Cell Line; CSK Tyrosine-Protein Kinase; Cytokines; ErbB Receptors; Inflammation Mediators; Lipopolysaccharides; Macrophages; Protein Kinase Inhibitors; Quinazolines; Rats; Signal Transduction; src-Family Kinases; Toll-Like Receptor 4; Tyrphostins | 2017 |
Reversible meiotic arrest of bovine oocytes by EGFR inhibition and follicular hemisections.
Topics: Angiotensin II; Animals; Cattle; Cell Cycle Checkpoints; Cumulus Cells; Dinoprostone; Embryo Culture Techniques; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Granulosa Cells; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Ovarian Follicle; Quinazolines; RNA, Messenger; Signal Transduction; Tyrphostins | 2017 |
Influence and mechanism of 5-aminolevulinic acid-photodynamic therapy on the metastasis of esophageal carcinoma.
Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Chromones; Down-Regulation; Drug Therapy, Combination; Esophageal Neoplasms; Female; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Morpholines; Photochemotherapy; Photosensitizing Agents; Protein Kinases; Quinazolines; Signal Transduction; Tyrphostins | 2017 |
Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Down-Regulation; ErbB Receptors; Humans; Indoles; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Signal Transduction; Sulfonamides; Transcriptional Activation; Tyrphostins | 2017 |
Inhibition of EGFR attenuates fibrosis and stellate cell activation in diet-induced model of nonalcoholic fatty liver disease.
Topics: Animals; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; ErbB Receptors; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Quinazolines; Rats; Tyrphostins | 2018 |
Suppressors for Human Epidermal Growth Factor Receptor 2/4 (HER2/4): A New Family of Anti-Toxoplasmic Agents in ARPE-19 Cells.
Topics: Afatinib; Aminoquinolines; Aniline Compounds; Animals; Cell Line; Gefitinib; Humans; Mice, Inbred BALB C; Protein Kinase Inhibitors; Quinazolines; Quinazolinones; Quinolines; Receptor, ErbB-2; Toxoplasma; Tyrphostins | 2017 |
The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways.
Topics: Administration, Intranasal; Animals; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Enzyme Inhibitors; Eosinophilia; Eosinophils; Epithelial Cells; ErbB Receptors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Nasal Mucosa; Neutrophil Infiltration; Quinazolines; Rats; Respiratory Mucosa; Thrombin; Tyrphostins | 2018 |
Poly (ethylene-co-vinyl alcohol) is a suitable substrate for human olfactory neuroepithelial cell differentiation in vitro through a defined regulatory pathway.
Topics: Amphiregulin; Biomarkers; Cell Differentiation; Cells, Cultured; Humans; Neuroepithelial Cells; Neurons; Neuropeptide Y; Olfactory Mucosa; Polyvinyls; Quinazolines; Schwann Cells; Signal Transduction; Tyrphostins | 2018 |
The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries.
Topics: Animals; Cells, Cultured; Coronary Vessels; Cyclopentanes; ErbB Receptors; Flavonoids; Humans; In Vitro Techniques; MAP Kinase Signaling System; Models, Cardiovascular; Myocytes, Smooth Muscle; Quinazolines; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Swine; Transcriptional Activation; Tyrphostins; Vasodilation | 2018 |
Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II).
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Hyperalgesia; Male; Nociceptors; Pain Threshold; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Signal Transduction; Tyrphostins | 2018 |
TGF-β1 promotes cell barrier function upon maturation of corneal endothelial cells.
Topics: Adult; Aged; Antigens, CD; Benzamides; Cadaver; Cadherins; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Dioxoles; Endothelial Cells; Endothelium, Corneal; Humans; Intercellular Junctions; Middle Aged; Phenotype; Quinazolines; Transforming Growth Factor beta1; Tyrphostins; Young Adult; Zonula Occludens-1 Protein | 2018 |
Epidermal Growth Factor Receptor Regulation of Ewing Sarcoma Cell Function.
Topics: Bone Neoplasms; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; G1 Phase Cell Cycle Checkpoints; Humans; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Sarcoma, Ewing; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins | 2018 |
EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non‑small cell lung cancer cells.
Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Molecular Targeted Therapy; Quinazolines; Telomerase; Tyrphostins | 2018 |
Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas.
Topics: Adenoma; Animals; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; EGF Family of Proteins; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Growth Hormone-Secreting Pituitary Adenoma; Humans; Mice; Neoplasm Invasiveness; Quinazolines; Rats; RNA Interference; Signal Transduction; Tyrphostins | 2018 |
Inhibition of Epidermal Growth Factor Receptor (EGFR) Reduces Lipopolysaccharide (LPS)-Induced Activation and Inflammatory Cytokines in Hepatic Stellate Cells In Vitro.
Topics: Animals; Cell Proliferation; Cell Survival; Cytokines; ErbB Receptors; Extracellular Matrix; Gene Knockdown Techniques; Genes, src; Hepatic Stellate Cells; Inflammation; Lipopolysaccharides; Liver; Liver Cirrhosis; Male; NF-kappa B; Primary Cell Culture; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4; Transforming Growth Factor beta; Tyrphostins | 2018 |
FOS, a Critical Downstream Mediator of PGR and EGF Signaling Necessary for Ovulatory Prostaglandins in the Human Ovary.
Topics: Adult; Benzophenones; Cells, Cultured; Chorionic Gonadotropin; Dinoprostone; Epidermal Growth Factor; Female; Humans; Isoxazoles; Mifepristone; Ovarian Follicle; Ovulation; Primary Cell Culture; Progesterone; Proto-Oncogene Proteins c-fos; Quinazolines; Receptors, Progesterone; RNA, Small Interfering; Signal Transduction; Tyrphostins; Up-Regulation | 2018 |
EGFR inhibitor, AG1478, inhibits inflammatory infiltration and angiogenesis in mice with diabetic retinopathy.
Topics: Animals; Diabetic Retinopathy; Disease Progression; ErbB Receptors; Female; Inflammation; Macrophages; Male; Mice; Mitochondria; Neovascularization, Pathologic; Protein Kinase Inhibitors; Quinazolines; Retinal Vessels; Tyrphostins | 2019 |
Label-free imaging of epidermal growth factor receptor-induced response in single living cells.
Topics: Cell Line, Tumor; Cytochalasin B; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Microscopy, Fluorescence; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Single-Cell Analysis; Surface Plasmon Resonance; Tyrphostins | 2018 |
Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model.
Topics: Amiloride; Animals; Cell Line; Epithelial Cells; Epithelial Sodium Channels; Hypotonic Solutions; Kidney; Kinetics; Models, Theoretical; Protein Kinase Inhibitors; Protein Transport; Quinazolines; Sodium; Tyrphostins; Xenopus laevis | 2018 |
Anti-vasospastic Effects of Epidermal Growth Factor Receptor Inhibitors After Subarachnoid Hemorrhage in Mice.
Topics: Animals; Cetuximab; ErbB Receptors; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Subarachnoid Hemorrhage; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vasospasm, Intracranial | 2019 |
ErbB4 Receptors in the Medial Habenula Regulate Contextual Fear Memory.
Topics: Animals; Behavior Rating Scale; Conditioning, Classical; Fear; Freezing Reaction, Cataleptic; Habenula; Male; Memory; Mice; Mice, Inbred C57BL; Miniature Postsynaptic Potentials; Neuregulin-1; Pyrimidines; Quinazolines; Receptor, ErbB-4; RNA, Messenger; Tyrphostins | 2019 |
Roles for HB-EGF in Mesenchymal Stromal Cell Proliferation and Differentiation During Skeletal Growth.
Topics: Animals; Bone Resorption; Cell Differentiation; Cell Proliferation; Chondrocytes; Heparin-binding EGF-like Growth Factor; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Mice, Transgenic; Osteoblasts; Proto-Oncogene Proteins c-akt; Quinazolines; Skeleton; Smad Proteins; Tyrphostins | 2019 |
Differences in embryonic gene expression and quality indicate the benefit of epidermal growth factor receptor inhibitor during prematuration to improve competence in bovine oocytes.
Topics: Animals; Cattle; Embryo, Mammalian; Embryonic Development; Enzyme Inhibitors; Epidermal Growth Factor; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; In Vitro Oocyte Maturation Techniques; Quinazolines; Tyrphostins | 2019 |
Combined quantification of intracellular (phospho-)proteins and transcriptomics from fixed single cells.
Topics: Cell Differentiation; Cells, Cultured; Focal Adhesion Kinase 1; Gene Expression Profiling; Gene Expression Regulation; Humans; Keratinocytes; Phosphorylation; Proteomics; Quinazolines; Single-Cell Analysis; Tissue Fixation; Tyrphostins | 2019 |
Ultrasensitive amplification-free detection of protein kinase based on catalyzed assembly and enumeration of gold nanoparticles.
Topics: Adenosine Triphosphate; Adsorption; Animals; Biotin; Cattle; Cyclic AMP-Dependent Protein Kinases; Drug Evaluation, Preclinical; Ellagic Acid; Enzyme Assays; Gold; Humans; Immobilized Proteins; Limit of Detection; MCF-7 Cells; Metal Nanoparticles; Oligopeptides; Protein Kinase Inhibitors; Quinazolines; Streptavidin; Tyrphostins | 2019 |
Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion.
Topics: Animals; Apoptosis; Brain Ischemia; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Neuregulin-1; Neurons; Neuroprotective Agents; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, ErbB-4; Spatial Learning; Temporal Lobe; Tyrphostins | 2019 |
Stimulation of neuroendocrine differentiation in prostate cancer cells by GHRH and its blockade by GHRH antagonists.
Topics: Androgens; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Growth Hormone-Releasing Hormone; Humans; Male; Neuroendocrine Cells; PC-3 Cells; Prostatic Neoplasms; Quinazolines; Receptor, ErbB-2; Tyrphostins | 2020 |
Activation of Protein Kinase Cδ Contributes to the Induction of Src/EGF Receptor/ERK Signaling in Ammonia-treated Astrocytes.
Topics: Ammonia; Animals; Astrocytes; Cell Size; Cells, Cultured; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Indoles; Maleimides; Protein Kinase C-delta; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; Tyrphostins | 2020 |
EGFR inhibitor AG1478 blocks the formation of 3D structures mainly through ERK signaling pathway in Matrigel-induced 3D reconstruction of eccrine sweat gland-like structures.
Topics: Cell Culture Techniques; Cells, Cultured; Collagen; Drug Combinations; Eccrine Glands; ErbB Receptors; Humans; Janus Kinases; Laminin; MAP Kinase Signaling System; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins | 2020 |
Attenuating the Epidermal Growth Factor Receptor-Extracellular Signal-Regulated Kinase-Sex-Determining Region Y-Box 9 Axis Promotes Liver Progenitor Cell-Mediated Liver Regeneration in Zebrafish.
Topics: Animals; Animals, Genetically Modified; Butadienes; Cell Differentiation; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Liver Regeneration; MAP Kinase Signaling System; Nitriles; Quinazolines; SOX9 Transcription Factor; Stem Cells; Tyrphostins; Zebrafish | 2021 |
Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma.
Topics: Animals; Antineoplastic Agents; Azepines; Benzamides; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Grading; Protein Kinase Inhibitors; Quinazolines; Receptor, trkB; Tyrphostins; Xenograft Model Antitumor Assays | 2020 |
Normal vitreous promotes angiogenesi via the epidermal growth factor receptor.
Topics: Cell Movement; ErbB Receptors; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Physiologic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tissue Extracts; Tyrphostins; Vitreous Body | 2020 |
Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells.
Topics: Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Gold; Head and Neck Neoplasms; Humans; Metal Nanoparticles; Microscopy, Electron, Transmission; Quinazolines; Spectrum Analysis, Raman; Squamous Cell Carcinoma of Head and Neck; Tyrphostins | 2020 |
TNF-α-induced sympathetic excitation requires EGFR and ERK1/2 signaling in cardiovascular regulatory regions of the forebrain.
Topics: Animals; Blood Pressure; Cardiovascular System; ErbB Receptors; Heart Rate; Hemodynamics; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Prosencephalon; Protein Kinase Inhibitors; Quinazolines; Rats, Sprague-Dawley; Signal Transduction; Sympathetic Nervous System; Tumor Necrosis Factor-alpha; Tyrphostins | 2021 |
Activation of the spinal EGFR signaling pathway in a rat model of cancer-induced bone pain with morphine tolerance.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cancer Pain; Carcinoma 256, Walker; Drug Tolerance; Enzyme Inhibitors; ErbB Receptors; MAP Kinase Signaling System; Microglia; Morphine; Phosphorylation; Quinazolines; Rats; Spinal Cord; Tibia; Tyrphostins | 2021 |
Morphine Prevents Ischemia/Reperfusion-Induced Myocardial Mitochondrial Damage by Activating δ-opioid Receptor/EGFR/ROS Pathway.
Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Mitochondria, Heart; Morphine; Myocytes, Cardiac; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Reactive Oxygen Species; Receptors, Opioid; Reperfusion; Reperfusion Injury; RNA, Small Interfering; Superoxides; Tyrphostins | 2022 |
Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional.
Topics: Adaptor Proteins, Signal Transducing; Amphiregulin; Biophysical Phenomena; Epithelium; ErbB Receptors; Fibroblasts; Genetic Predisposition to Disease; Humans; Idiopathic Pulmonary Fibrosis; Keratin-5; Lung; Mucin-5B; Quinazolines; Risk Factors; RNA, Messenger; Signal Transduction; Transcription Factors; Tyrphostins; Verteporfin; YAP-Signaling Proteins | 2021 |
Morphine promotes microglial activation by upregulating the EGFR/ERK signaling pathway.
Topics: Animals; CD11b Antigen; Cell Line; Cell Movement; Drug Tolerance; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Interleukin-1beta; Mice; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine; Phosphorylation; Quinazolines; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrphostins | 2021 |
Selective therapeutic benefit of X-rays and inhibitors of EGFR, PI3K/mTOR, and Bcl-2 in breast, lung, and cervical cancer cells.
Topics: Aniline Compounds; Breast Neoplasms; Cell Line; Cell Survival; ErbB Receptors; Female; Humans; Imidazoles; Lung Neoplasms; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Quinolines; Radiation Tolerance; Sulfonamides; TOR Serine-Threonine Kinases; Tyrphostins; Uterine Cervical Neoplasms; X-Rays | 2021 |
AG1478 Elicits a Novel Anti-Influenza Function via an EGFR-Independent, GBF1-Dependent Pathway.
Topics: Antiviral Agents; ErbB Receptors; Guanine Nucleotide Exchange Factors; Humans; Influenza, Human; Quinazolines; Signal Transduction; Tyrphostins | 2022 |