rtki cpd and quinazolines

rtki cpd has been researched along with quinazolines in 722 studies

Research

Studies (722)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's42 (5.82)18.2507
2000's385 (53.32)29.6817
2010's281 (38.92)24.3611
2020's14 (1.94)2.80

Authors

AuthorsStudies
Caday, CG; Cavenee, WK; Han, Y; Huang, HJ; Nanda, A1
Chelluderai, B; Dutta, S; Fligiel, SE; Jaszewski, R; Majumdar, AP; Tureaud, J1
Böhmer, FD; Fernández, LE; Greiser, U; Lage, A; Perez, R; Sánchez, B; Suarez Pestana, E1
Klein, JM; McCarthy, TA1
Ben-Bassat, H; Gal, I; Klein, BY; Shlomai, Z; Tepper, SH1
Levitzki, A; Osherov, N1
Berthelemy, M; Dangles, V; Féménia, F; Lainé, V; Le Rhun, D; Levy, D; Poupon, MF; Schwartz-Cornil, I1
Arteaga, CL; Guyer, CA; Ramsey, TT; Shawver, LK1
Ben-Bassat, H; Gazit, A; Hartzstark, Z; Kleinberger-Doron, N; Levitzki, A; Levitzki, R; Plowman, G; Rosenbaum-Mitrani, S; Shlomai, Z; Tsvieli, R1
Chen, PB; Contessa, JN; Dent, P; Kavanagh, BD; Mikkelsen, RB; Rorrer, WK; Schmidt-Ullrich, RK; Todd, DG; Valerie, K1
Cantley, LG; Kjelsberg, CA; Nigam, SK; Sakurai, H; Tsukamoto, T1
Breu, J; Muchnicki, L; Slack, BE; Wurtman, RJ1
Higashimoto, Y; Kanayama, S; Kiyohara, T; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Tsutsui, S; Zushi, S1
Iozzo, RV; Mann, DM; McQuillan, DJ; Moscatello, DK; Santra, M; Wong, AJ1
Antonyak, MA; Moscatello, DK; Wong, AJ1
Iozzo, RV; McQuillan, DJ; Patel, S; Santra, M; Thomas, AP1
Eguchi, S; Hirata, Y; Inagami, T; Iwasaki, H; Kawakatsu, H; Marumo, F; Matsumoto, T; Motley, ED; Numaguchi, K; Owada, KM; Utsunomiya, H; Yamakawa, T1
DeWild, LJ; Klein, JM; McCarthy, TA1
Cavenee, WK; Gazit, A; Huang, HJ; Levitzki, A; Nagane, M1
Eguchi, S; Hirata, Y; Iwasaki, H; Marumo, F1
Hartkamp, J; Rapp, UR; Troppmair, J1
Soltoff, SP1
Ben-Bassat, H; Klein, BY; Rojansky, N; Stekelenburg, J1
Dalmau, SR; Freitas, CS; Savino, W1
Barrett, KE; Keely, SJ; Uribe, JM1
Higashimoto, Y; Kanayama, S; Kiyohara, T; Kondo, S; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Zushi, S1
Farrell, GC; Zhang, BH1
Mei, L; Si, J1
Daaka, Y; Della Rocca, GJ; Lefkowitz, RJ; Luttrell, LM; Maudsley, S1
Gohla, A; Offermanns, S; Schultz, G; Wilkie, TM1
Akhand, AA; Kato, M; Kurokawa, K; Liu, W; Miyata, T; Nakashima, I; Uchida, K; Yokoyama, I1
Bonner, JC; Moomaw, CR; Morgan, DL; Rice, AB1
Hochegger, K; Marian, B; Partik, G; Schörkhuber, M1
Allal, C; Asslan, R; Favre, G; Le Gaillard, F; Pradines, A; Pratx, C1
Brecher, P; Wang, D; Yu, X1
Gillham, H; Golding, MC; Gullick, WJ; Pepperkok, R1
Mikkelsen, RB; Rorrer, WK; Schmidt-Ullrich, RK; Todd, DG; Valerie, K1
Ben-Bassat, H; Chaouat, M; Chen, H; Gazit, A; Harzstark, Z; Klein, BY; Levitzki, A; Levitzki, R; McCollough, J; McMahon, J; Narog, B; Powell, TJ; Shawver, L; Shenoy, N; Tang, C1
Minneman, KP; Zhong, H1
Farrelly, ER; Ho, JJ; Kim, YS1
Polk, DB; Tong, W1
Eguchi, K; Eguchi, S; Frank, GD; Hirata, Y; Inagami, T; Iwasaki, H; Marumo, F; Motley, ED; Ueno, H1
Ogata, T1
Eguchi, S; Hirata, Y; Iwasaki, H; Marumo, F; Ueno, H1
Daaka, Y; Lefkowitz, RJ; Luttrell, LM; Maudsley, S; Pierce, KL1
Braun, L; Chase, CC; Frew, T; Hurley, DJ; Rowland, RR; Shaw, AM1
Cupp, AS; Levine, E; Miyashiro, L; Skinner, MK1
Guo, C; Luttrell, LM; Price, DT1
Arteaga, CL; Busse, D; Doughty, RS; Flanagan, WM; Price, JO; Ramsey, TT; Russell, WE; Shawver, LK1
Abe, K; Saito, H1
Jensen, RL; Petr, M; Wurster, RD1
Dorko, K; Esplen, JE; Jo, M; Michalopoulos, GK; Stolz, DB; Strom, SC1
Jope, RS; Song, L; Zhang, L1
Carpenter, G; Ji, QS1
Barrett, KE; Calandrella, SO; Keely, SJ1
Bonner, JC; Wang, YZ1
Dalbone, AC; Hutcheon, AE; Takahashi, H; Zieske, JD1
DeMattia, JA; Khoshyomn, S; Naraghi, S; Vane, DW1
Abraham, JA; Clowes, AW; Daum, G; Kalmes, A; Vesti, BR1
Bates, SE; Bishop, PC; Blagosklonny, MV; Fojo, T; Robey, R1
Arteaga, CL; Coffey, RJ; Forbes, JT; Lenferink, AE; Shawver, LK; Simpson, JF1
Bergström, JD; Heldin, NE; Westermark, B1
del Carmen Medina, L; García-Sáinz, JA; Vázquez-Prado, J1
Jue, SF; Maurer, RA; Wang, YH1
Bagnato, A; Catt, KJ; Tecce, R; Vacca, F1
Brattain, MG; Jackson, JG; Koterba, AP; Kreisberg, JI; Yee, D1
Arteaga, CL; Forbes, JT; Kurokawa, H; Lenferink, AE; Pisacane, PI; Simpson, JF; Sliwkowski, MX1
Delouvée, A; el-Marjou, A; Radvanyi, F; Thiery, JP1
Fujiyama, S; Higashiyama, S; Iba, O; Iwasaka, T; Jyo, N; Koyama, Y; Maruyama, K; Masaki, H; Matsubara, H; Mori, Y; Nose, A; Nozawa, Y; Ogata, N; Tateishi, E; Tsutsumi, Y; Uchiyama, Y1
Eichstetter, I; Häkkinen, L; Kähäri, VM; Larjava, H; Lozzo, RV; Scott, PG; Strassburger, S1
Conway, A; Pyne, NJ; Pyne, S1
Billestrup, N; Brender, C; Kaltoft, K; Mikkelsen, G; Nielsen, M; Odum, N; Wasik, M; Zhang, Q1
Eguchi, S; Frank, GD; Inagami, T; Motley, ED1
Cavenee, WK; Huang, HJ; Lin, H; Nagane, M1
Egeblad, M; Jäättelä, M; Mortensen, OH; van Kempen, LC1
Belt, A; Fisher, G; Voorhees, J; Wan, Y; Wang, Z1
Chun, JS; Kim, JH; Song, WK1
Carmines, PK; Che, Q; Fallet, RW; Fujiwara, K1
Berven, LA; Crouch, MF; Davy, DA; Willard, FS1
Berk, BC; Chen, K; Keaney, JF; Vita, JA1
Adrian, TE; Cluck, MW; Knezetic, JA; Larsson, J; Lovas, S; Murphy, LO; Murphy, RF; Otvös, F; Permert, J; Schally, AV1
Kanda, Y; Kuroki, Y; Mizuno, K; Watanabe, Y1
Burchiel, SW; Burdick, AD; Davis, JW; Hudson, LG; Lauer, FT1
Amir, C; Bowers, G; Dent, P; Hewitt, T; Lammering, G; Mikkelsen, RB; Reardon, D; Schmidt-Ullrich, RK; Valerie, K1
Burgess, AW; Ellis, AG; Levitzki, A; Nice, EC; Webster, LK; Weinstock, J1
Haslett, C; Jodrell, D; MacKinnon, AC; Sethi, T; Waters, C1
Lavictoire, SJ; Lorimer, IA1
Chavis, P; Westbrook, G1
Huggett, TM; Jost, M; Kari, C; Rodeck, U1
Feng, GK; Li, ZM; Liu, ZC; Xie, BF; Yang, D; Zeng, YX; Zhu, XF1
Sagi-Eisenberg, R; Shefler, I1
Devlin, RB; Ghio, AJ; Samet, JM; Wu, W1
Nishinaka, T; Yabe-Nishimura, C1
Kodama, S; Suzuki, K; Watanabe, M1
Adachi, H; Fujioka, T; Kim, JH; Saito, K; Tsujimoto, M; Ui, M; Yokoyama, S1
Rozengurt, E; Santiskulvong, C; Sinnett-Smith, J2
Arteaga, CL; Busse, D; Flanagan, WM; Lenferink, AE; Yakes, FM1
Burgess, AW; Cavenee, WK; Huang, HJ; Levitzki, A; Mishima, K; Nagane, M; Narita, Y1
Bourdoulous, S; Couraud, PO; Eugène, E; Hoffmann, I; Nassif, X1
Pouysségur, J; Viñals, F1
Bode, AM; Chen, N; Dong, Z; Liu, G; Ma, WY; She, QB; Wu, E1
Keates, AC; Keates, S; Kelly, CP; Peek, RM; Shaw, LM; Sougioultzis, S; Zhao, D1
Brattain, MG; Ghosh, P; Humphrey, LE; Kreisberg, JI; Sawhney, RS; Zhou, GH1
Fukuda, K; Kato, T; Kodama, H; Miyoshi, S; Ogawa, S; Tahara, S1
Atabai, K; Birch, M; Burgel, PR; Lazarus, SC; Nadel, JA; Tam, DC; Ueki, IF1
Adler, KB; Bonner, JC; Booth, BW; Martin, LD; Tournier, F1
Chang, MS; Conn, PJ; Peavy, RD; Sanders-Bush, E1
Chen, K; Keaney, JF; Thomas, SR1
Cavenee, WK; Huang, HJ; Steinbach, JP; Supra, P; Weller, M1
El-Obeid, A; Hesselager, G; Nistér, M; Westermark, B1
Chakravarti, A; Dyson, NJ; Loeffler, JS1
Bates, SE; Bishop, PC; Blagosklonny, MV; Fry, DW; Liu, ET; Myers, T; Robey, R1
Avkiran, M; Hearse, DJ; Snabaitis, AK1
Gildea, JJ; Gulding, KM; Harding, MA; Seraj, MJ; Theodorescu, D1
Alberto Olivares-Reyes, J; Catt, KJ; Shah, BH; Yesilkaya, A1
Baatar, D; Pai, R; Pavelka, M; Soreghan, B; Szabo, IL; Tarnawski, AS1
Bode, AM; Chen, N; Dong, Z; Ma, WY; Zhang, Y1
Carreras, I; DiCamillo, SJ; Foster, JA; Nugent, MA; Panchenko, MP; Panchenko, MV; Stone, PJ1
Cussac, D; Denis, C; Paris, H; Schaak, S1
Choi, BH; Choi, JS; Hahn, SJ; Jo, YH; Kim, MS; Min, DS; Rhie, DJ; Yoon, SH1
Eckhart, AD; Eguchi, S; Kim, J; Koch, WJ1
Liang, NC; Liu, XG1
Enrich, C; Lladó, A; Tebar, F1
Gamady, A; Koren, R; Liberman, UA; Ravid, A; Rotem, C; Rubinstein, E1
Archer, GE; Friedman, HS; Glazer, CA; Lal, A; Martinson, HM; Riggins, GJ; Sampson, JH1
Aguirre Ghiso, J; Estrada, Y; Liu, D; Ossowski, L1
Montgomery, RB1
Chen, MC; Kui, R; Perez Salazar, E; Rozengurt, E; Soll, AH; Solomon, TE1
Barrett, KE; McCole, DF; Uribe, JM1
Carter, RW; Kanagy, NL1
Al-Ghoul, WM; Choudhry, MA; Fazal, N; Sayeed, MM; Schmidt, MJ1
Cohen, MV; Downey, JM; Krieg, T; McIntosh, EC; Qin, Q1
Cowen, DS; Johnson-Farley, NN; Quinn, JC; Yoon, J1
Chen, X; Resh, MD1
Carmines, PK; Che, Q1
Chan, FL; Chang, C; Huang, J; Lee, YF; Lin, WJ; Messing, EM; Wilding, G1
Gschwind, A; Prenzel, N; Ullrich, A1
Koty, PP; Lei, W; Levitt, ML1
Levin, ER; Park, ST; Pedram, A; Razandi, M1
Huang, XL; Lawrence, M; Madara, P; Nanavaty, UB; Pawliczak, R; Shelhamer, JH1
Dobashi, K; Ishizuka, T; Kawata, T; Mori, M; Shimizu, Y; Tsukagoshi, H1
Chen, X; Pennock, S; Wang, Y; Wang, Z1
Chatziantoniou, C; Coffman, T; Dussaule, JC; Flamant, M; Henrion, D; Placier, S; Tharaux, PL1
Alonso, A; Dürst, M; Leykauf, K1
Collins, JF; Ghishan, FK; Hines, ER; Inouye, M; Xu, H1
Hunger-Glaser, I; Rozengurt, E; Salazar, EP1
Busse, R; Fisslthaler, B; Fleming, I; Harder, D; Medhora, M; Michaelis, UR1
Dartt, DA; Hodges, RR; Tepavcevic, V; Zoukhri, D1
Bringmann, A; Milenkovic, I; Reichenbach, A; Weick, M; Wiedemann, P1
Chung, T; Dent, P; Hagan, MP; Hinman, D; McKinstry, R; Yacoub, A1
Lorita, J; Pareja, M; Ramírez, I; Sánchez, O; Soley, M1
Chan, SY; Mak, KK1
Ahmed, I; Drezner, MK; Gesty-Palmer, D; Luttrell, LM1
Arbel, R; Ben-Bassat, H; Hartzstark, Z; Klein, BY; Laufer, N; Levitzki, R; Rojansky, N1
Bernardino, CR; Chang, EL; Dartt, DA; Hodges, RR; Horikawa, Y; Rios, JD; Rubin, PA; Shatos, MA; Zoukhri, D1
Amornphimoltham, P; Gutkind, JS; Nelkin, BD; Park, JI; Patel, V; Sriuranpong, V1
Singer, M; Vargaftig, BB1
Chen, Z; Rola-Pleszczynski, M; Stankova, J1
Fung, KY; Hertz, L; Peng, L; Prévot, V; Yu, AC1
Davidson, AJ; Goishi, K; Klagsbrun, M; Lee, P; Nishi, E; Zon, LI1
Hidaka, K; Morisaki, T; Suk Kim, H1
Amorino, GP; Contessa, JN; Dent, P; Hewit, TH; Lammering, G; Schmidt-Ullrich, RK; Valerie, K1
Marcoux, N; Vuori, K1
Abbou, CC; Chopin, DK; Daher, A; de Boer, WI; El-Marjou, A; Radvanyi, F; Thiery, JP; van der Kwast, T1
Degen, SJ; Hill, KJ; Peace, BE; Waltz, SE1
Chokki, M; Eguchi, H; Horiuchi, H; Kamimura, T; Masegi, T; Tanabe, H; Yamamura, S; Yasuoka, S1
Gui, Y; Zheng, XL1
El-kholy, W; MacDonald, PE; Targonsky, ED; Tsushima, RG; Wang, X; Wheeler, MB; Xia, F1
Mattingly, RR; Menard, RE1
Cheng, K; Raufman, JP; Zimniak, P1
Barrett, KE; Bertelsen, LS; Keely, SJ1
Burgess, AW; Johns, TG; Jungbluth, AA; Luwor, RB; Murone, C; Nice, EC; Old, LJ; Perera, RM; Scott, AM; Stockert, E; Vitali, AA; Walker, F; Weinstock, J1
Berezin, V; Pedersen, MW; Pedersen, N; Poulsen, HS; Tkach, V1
Ashida, M; Bito, T; Budiyanto, A; Ichihashi, M; Kunisada, M; Ueda, M1
González, A; Guerrero, J; Martínez, J; Santibañez, JF1
Klumpp, A; Steinbach, JP; Weller, M; Wolburg, H1
Darmoul, D; Devaud, H; Gratio, V; Laburthe, M1
Brandes, RP; Busse, R; Geiger, H; Jung, O; Pedrazzini, T; Schreiber, JG1
Berk, BC; Lungu, AO; Tanimoto, T1
Dowlati, A; Kern, JA; Nethery, D1
Arany, I; Kaneto, H; Megyesi, JK; Price, PM; Safirstein, RL1
Chan, AS; Wong, YH1
Ben-Bassat, H; Hartzstark, Z; Klein, BY; Laufer, N; Levitzki, R; Rojansky, N; Shlomai, Z; Shushan, A1
Prydz, H; Wiiger, MT1
Evdonin, AL; Margulis, BA; Medvedeva, ND; Tsupkina, NV1
Adachi, T; Chihara, J; Cui, CH; Kanda, A; Kayaba, H; Ohta, K1
Brown, EM; Chattopadhyay, N; MacLeod, RJ; Yano, S1
Chen, R; Morinelli, TA; Paul, RV; Ullian, ME; Webb, JG1
Kataoka, K; Kurabayashi, T; Kuribayashi, A; Miura, M1
Barki-Harrington, L; El-Shewy, HM; Kelly, FL; Luttrell, LM1
De Tribolet, N; Diserens, AC; Godard, S; Hamou, MF; Hegi, ME; Kobayashi, H; Lachat, Y; Nozaki, M1
Abulrob, A; Andrade, MF; Giuseppin, S; McDermid, A; Moreno, M; Stanimirovic, D1
Abraham, S; Egan, LJ; Myhre, GM; Toruner, M1
Liu, B; Neufeld, AH1
Basuroy, S; Rao, RK; Seth, A; Sheth, P1
Götte, M; Kresse, H; Sofeu Feugaing, DD1
Bowling, GH; Khan, SA; Millena, AC; Reddy, SC1
Chen, Z; Grandis, JR; Li, M; Shin, DM; Wang, Z; Wieand, HS; Zhang, X1
Franklin, RA; McCubrey, JA; McMahon, M; Shelton, JG; Sreevalsan, T; Steelman, LS1
Gavard, J; Mège, RM; Monnet, C; Sobel, A1
Chalothorn, D; Faber, JE; Jackson, LF; Lee, DC; Zhang, H1
Kolachana, P; Lawsin, LM; Moore, J; Perlman, A; Ringel, MD; Saji, M1
Campadelli-Fiume, G; Gianni, T; Menotti, L1
Bronk, SF; Gores, GJ; Gwak, GY; Lee, HS; Werneburg, NW; Yoon, JH1
Bernd, A; Guschel, M; Kaufmann, R; Kippenberger, S; Knies, Y; Loitsch, S; Müller, J1
Chen, QM; Purdom, S1
Higgins, CE; Higgins, PJ; Higgins, SP; Kutz, SM; Samarakoon, R1
Davidson, C; Davidson, WR; Dicker, AP; Farber, SA; McAleer, MF; Rodeck, U; Yentzer, B1
Abud, HE; Heath, JK; Watson, N1
Condeelis, J; Coniglio, S; Eddy, R; Kempiak, S; Lorenz, M; Miki, H; Sarmiento, C; Segall, J; Symons, M; Takenawa, T; Yamaguchi, H1
Ishii, T; Masuda, M; Matsuse, T; Teramoto, S1
Bertrand, FE; Green, TD; McCubrey, JA; Spengeman, JD1
Long, HC; Wang, G; Wang, ZH; Wang, ZL; Xiao, BR1
Cheng, J; Chu, EK; Drazen, JM; Foley, JS; Patel, AS; Tschumperlin, DJ1
Kanje, M; Nilsson, A1
Chen, L; Gao, P; Ma, D; Oppenheim, JJ; Sun, R; Wang, J; Zhang, N1
Akhtar, S; Benter, IF; Yousif, MH1
Bagnato, A; Di Castro, V; Elia, G; Natali, PG; Rosanò, L; Spinella, F1
Beaucage, P; Moreau, P1
Akhtar, S; Benboubetra, M; Benter, IF; Griffiths, SM; Yousif, MH1
Buck, DC; Macey, TA; Neve, KA; Wang, C; Yang, R1
Boulesteix, C; Gall, L; Germain, G; Ruffini, S1
Carbone, DP; Dang, TP; Eichenberger, S; Gonzalez, A; Haruki, N; Kawaguchi, KS; Massion, PP; Olson, S1
El-Abaseri, TB; Fuhrman, J; Hansen, LA; Shendrik, I; Tennant, RW; Trempus, C1
Chan, CT; Kane, SE; Metz, MZ1
Baibakov, G; Emmert-Buck, MR; Gutkind, JS; Knezevic, V; Patel, V; Ramesh, A; Traicoff, JL1
Burgess, AW; Clayton, AH; Nice, EC; Perugini, MA; Rothacker, J; Watson, KG; Weinstock, J1
Neufeld, AH; Zhang, X1
Delamere, NA; Tamiya, S1
Catt, KJ; Chu, DB; Neithardt, A; Shah, BH; Shah, FB1
Fujioka, A; Itoh, RE; Kurokawa, K; Matsuda, M; Mayer, BJ; Sharma, A1
Chicoine, LG; English, BK; Liu, Y; Nelin, LD; Reber, KM; Young, TL1
Brattain, MG; Zhou, Y1
Bao, Y; Ding, YB; Li, XY; Shi, RH; Tong, JD; Wang, XH; Wu, J; Xiao, WM; Yan, ZG; Yang, JG; Zhang, GX1
Halgunset, J; Larsson, E; Skogseth, H3
Bigner, DD; Kwatra, MM; Richardson, MD; Yamaguchi, K1
El Shewy, H; Gesty-Palmer, D; Kohout, TA; Luttrell, LM1
Jones, PL; Martinez, EC; Merklinger, SL; Rabinovitch, M1
Egami, H; Hirota, M; Ogawa, M; Takai, E; Tamori, Y; Tan, X1
Churg, A; Vincent, R; Wang, RD; Wang, X; Xie, C1
Finlay, D; Furlong, F; Martin, F1
Bunting, M; Hanson, BJ; Hanson, GT; O'Grady, M; Raha, D1
Brechbiel, MW; Burgess, AW; Hall, C; Johns, TG; Kelly, MP; Lee, FT; Mountain, AJ; Nice, EC; Rigopoulos, A; Scott, AM; Smyth, FE1
Atwal, J; Chen, DF; Cho, KS; Gore, B; He, Z; Kim, JA; Koprivica, V; Lin, E; Park, JB; Tessier-Lavigne, M; Yiu, G1
Mariappa, D; Seshagiri, PB; Shivaji, S; Siva, AB1
Kitayama, J; Mori, K; Nagawa, H; Shida, D; Watanabe, T1
Higashiyama, S; Itoh, M; Joh, T; Kataoka, H; Nakao, H; Ohhara, H; Ohshima, T; Sasaki, M; Tanida, S; Watanabe, K1
Kitayama, J; Mori, K; Nagawa, H; Shida, D; Watanabe, T; Yamashita, H1
Abe, M; Egami, H; Hirota, M; Nozawa, F; Ogawa, M; Tan, X1
Kim, SY; Kim, YK; Kwon, CH; Lee, JS1
Kim, HJ; Kim, JH1
Bertagnolli, MM; Carothers, AM; Hunt, DH; Javid, SH; Moran, AE; Redston, M1
Fishman, DA; Kang, S; Luo, R; Meng, Y; Smicun, Y1
Brattain, MG; Conway, AN; Hauser, J; Hu, YP; Humphrey, L; Li, S; Vinci, MA; Wang, J; Willson, JK; Zborowska, E; Zhou, Y1
Abe, M; Handa, T; Hirose, M; Kuroda, Y; Nakano, M; Watanabe, Y1
Cai, K; Enomoto, A; Hosoi, Y; Li, Z; Matsumoto, Y; Miyagawa, K; Morita, A; Nakagawa, K; Tanno, Y1
Fernandez-Patron, C; Hao, L; Nishimura, T; Wo, H1
Chokki, M; Kamimura, T; Mitsuhashi, H1
Hur, GY; In, KH; Jung, HC; Jung, KH; Kang, EJ; Kang, KH; Kim, JH; Lee, SY; Shim, JJ; Shin, C; Yoo, SH1
Bolotin, D; Chu, DH; Fuchs, E; Polak, L; Wang, X; Williams, T1
Allen, RR; Higgins, CE; Higgins, PJ; Higgins, SP; Kutz, SM; Qi, L; Samarakoon, R1
Adams, JW; Brown, JH; Howes, AL; Miyamoto, S; Woodcock, EA1
Lipscomb, EA; Shin, S; Yoon, SO1
Burgess, AW; Doherty, MM; Ellis, AG; Johns, TG; Levitzki, A; McLachlan, G; Murphy, R; Nerrie, M; Nice, EC; Scott, AM; Vitali, A; Walker, F; Webster, LK; Weinstock, J1
Bergmann, S; Henklein, P; Hollenberg, MD; Junker, K; Kaufmann, R; Settmacher, U1
Ancha, HB; Ancha, HR; Harty, RF; Tedesco, DS; Ward, AR1
Drumm, K; Gassner, B; Gekle, M; Kress, TR; Krug, AW1
Awooda, I; Barhoumi, R; Burghardt, RC; Mouneimne, Y; Safe, S1
Alagarsamy, S; Alexander, LD; Cui, XL; Ding, Y; Douglas, JG1
Ascoli, M; Shiraishi, K2
Fukumoto, RH; Furukawa, S; Kimura, H; Nakajima, S; Nishina, A; Sekiguchi, A1
Brown, KA; Emlet, DR; Pollice, AA; Schwartz, R; Shackney, SE; Smith, CA1
Halgunset, J; Holt, RU; Larsson, E; Skogseth, H1
Davies, GC; Lipkowitz, S; Rahman, L; Ryan, PE; Zajac-Kaye, M1
Follestad, T; Halgunset, J; Larsson, E; Skogseth, H1
Fujimoto, S; Fukuda, T; Ishii, Y1
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Arao, T; Maegawa, M; Matsumoto, K; Nishio, K1
Alberti, C; Canevari, S; Ditto, A; Ferri, R; Pinciroli, P; Sensi, M; Tomassetti, A; Umezawa, K; Valeri, B1
Cao, SX; Chen, XJ; Chen, Z; Duan, S; Li, KX; Li, XM; Lu, YM; Luo, JH; Xu, ZH; Zhang, J; Zhang, JM; Zhu, JM1
Chen, J; Fan, Y; Li, Q; Xing, X; Yu, Q; Zhan, H; Zhan, L; Zhang, Y1
Furukawa, M; Inoue, H; Kakudo, K; Nozaki, M; Ohnishi, Y1
Groves, AK; Segil, N; Stone, JS; White, PM1
Bankaitis, ED; Rinella, ES; Threadgill, DW1
Bharti, A; Icli, B; Peng, X; Pentassuglia, L; Sawyer, DB1
Iwao, H; Izumi, Y; Kita, H; Osada-Oka, M; Sato, T; Yagi, S1
Chung, KF; Huang, CD; Huang, TT; Kuo, HP; Lee, KY; Lin, HC; Lin, SM; Lo, YL; Wang, CH1
Pick, A; Wiese, M1
Gashaw, I; Klein, R; Stiller, S1
Fu, S; Li, P; Li, ZB; Lu, B; Torossian, A; Xu, WC; Zhang, Q1
Craven, RJ; Jin, L; Mir, SU1
Carpenter, G; Liao, HJ1
Ikari, A; Sato, T; Sugatani, J; Watanabe, R; Yamazaki, Y1
Baeza-Squiban, A; Hamel, R; Marano, F; Ramgolam, K; Rumelhard, M1
Chmielinska, JJ; Kramer, JH; Mak, IT; Spurney, CF; Weglicki, WB1
Choi, SK; Galán, M; Henrion, D; Kassan, M; Matrougui, K; Partyka, M; Trebak, M1
Chen, SY; Hsu, HC; Huang, CY; Tang, CH; Tsai, HC1
Allende, ML; Carrillo, SA; Martin, SM; O'Donnell, KC; Sagasti, A; Villegas, R1
Barbieri, MA; Jozic, I; Saliba, SC1
Chang, LS; Chiu, CC; Hsieh, CY; Lin, SR; Tsai, PC; Wang, CK1
Fu, S; Li, P; Torossian, A; Xu, WC; Zhang, Q1
Rinella, ES; Threadgill, DW1
Adamczyk, A; Bojko, A; Klein, A; Ligęza, J; Reichert, K1
Goto, S; Hirose, Y; Miyazaki, H; Nishijima, F; Niwa, T; Shimizu, H; Zghonda, N; Zrelli, H1
Cebrián-Pérez, JA; Colás, C; Luna, C; Muiño-Blanco, T; Pérez-Pé, R1
An, SW; Chen, E; Chong, BH; Khachigian, LM; Kockx, M; Sanchez-Guerrero, E1
Fang, J; Guo, ZB; Lü, JG; Qu, WS; Tian, DS; Wang, W; Xie, MJ; Yu, ZY; Zhang, HQ; Zhang, Q1
Cho, NJ; Park, YS1
Fan, SM; Ikejima, T; Onodera, S; Tashiro, S; Ye, YC; Yu, Y1
Bissell, MJ; Furuta, S; Kenny, PA; Lee, SY; Lenburg, ME; Meier, R; Xu, R1
Barnette, NK; Chai, KX; Chen, LM; Fu, YY; Nergard, JC; Wang, YL1
Bae, YK; Choi, MS; Hong, KM; Kim, HT; Kim, S; Kim, YN; Kwon, JY; Shim, J; Sung, JY1
Beck, PL; Buret, A; Hirota, CL; Hollenberg, MD; Jijon, HB1
Jin, X; Joshi, K; Kim, H; Kim, SH; Nakano, I; Nam, DH; Sohn, YW; Yin, J1
Bian, F; Chen, Q; Han, Y; Li, G; Mu, X; Wang, J; Wen, J; Xia, G; Zhang, M; Zhou, J1
Ai, Z; Teng, Y; Wang, J; Xu, Y; Yan, Y1
Abrams, SL; Candido, S; Cervello, M; Chappell, WH; Franklin, RA; LaHair, MM; Libra, M; Martelli, AM; McCubrey, JA; Milella, M; Montalto, G; Nicoletti, F; Polesel, J; Steelman, LS; Tafuri, A; Talamini, R1
Chen, C; Chuang, TH; Liao, D; Liu, Y; Luo, Y; Markowitz, D; Reisfeld, RA; Xiang, R; Yang, J1
Jiang, Y; Lu, F; Sun, X; Wang, F; Wang, W; Xu, S; Zhang, L1
Kim, HS; Lee, SY; Shin, SJ1
Afratis, N; Ellina, MI; Gialeli, C; Karamanos, NK; Piperigkou, Z; Skandalis, SS; Theocharis, AD; Tsonis, AI; Tzanakakis, GN1
Atlas, MD; Dilley, RJ; Marano, RJ; Mei Teh, B; Redmond, SL; Shen, Y1
Ishiguro, H; Ishiguro, Y; Miyamoto, H1
Hryciw, DH; Jang, Y; Kruger, WA; Lee, A; Poronnik, P; Slattery, C1
Geller, BJ; Hirota, N; Jo, T; Martin, JG; McGovern, TK; Novali, M; Risse, PA; Siddiqui, S; Tsuchiya, K; Zeroual, MA1
Bi, LL; Chen, M; Gan, XD; Wang, YG; Wang, ZQ; Zhao, F1
Buyukafsar, K; Kurt, AH; Tiftik, RN; Ulker, S; Un, I1
Fernández-Martínez, AB; Lucio Cazaña, FJ1
Berg, K; Selbo, PK; Weyergang, A1
Carson, DD; Engel, BJ1
Nie, W; Rodriguez Perez, CE; Rozengurt, E; Sinnett-Smith, J; Yoo, J1
Armstrong, SP; Ayoub, MA; Pfleger, KD; See, HB; Seeber, RM1
Fu, S; Li, P; Li, ZB; Veldwijk, MR; Xu, WC; Zhang, Q1
Alemi, F; Bunnett, NW; Canals, M; Corvera, CU; Cottrell, GS; Godfrey, CB; Jensen, DD; Kocan, M; Korbmacher, C; Lambert, NA; Murphy, JE; Niklas, C; Poole, DP1
Cooley, C; Dobberfuhl, AD; Goldschmeding, R; Higgins, PJ; Meldrum, KK; Overstreet, JM; Patel, S; Samarakoon, R1
Liu, YP; Luo, YH; Song, JG; Sun, P; Xu, HM; Zhang, L; Zhang, XJ1
Gao, FH; Guo, YH; Jiang, B; Shi, J; Yuan, HH1
Inase, N; Miyazaki, Y; Okayasu, K; Sumi, Y; Takayama, S; Tamaoka, M; Yoshizawa, Y1
Higashiyama, S; Hosoi, H; Masui, T; Matsuura, N; Ota, I; Yane, K1
Fälting, JM; Holmström, TE; Mattsson, CL; Nedergaard, J; Wang, Y1
Kawanishi, S; Midorikawa, K; Murata, M1
Ahmadova, Z; Hafner, M; Hajiyeva, Y; Keese, M; Yagublu, V1
Cao, L; Freeman, JW; Hill, P; Nawrocki, ST; Peterson, L; Venkatasubbarao, K; Zhao, S; Zhou, Q1
Andric, N; Fa, S; Kaisarevic, S; Kovacevic, R; Odzic, L; Pogrmic-Majkic, K; Samardzija, D1
Chang, CM; Chang, WC; Chuang, HY; Hou, MF; Lee, YC; Lin, YC; Tsai, YT; Wang, JY; Wei, PL; Wong, JH1
Buttitta, G; Carlisi, D; D'Anneo, A; Di Fiore, R; Emanuele, S; Lauricella, M; Tesoriere, G; Vento, R1
Barbeau, A; Beaulieu, JM; De Koninck, Y; Godin, AG; Swift, JL; Wiseman, PW1
Benterki, I; Fontés, G; Peyot, ML; Poitout, V; Prentki, M; Seda, O; Zarrouki, B1
Cui, M; Dong, Q; Lu, Z; Shen, Y; Wang, T; Zhao, H1
Cho-Clark, M; Larco, DO; Mani, SK; Semsarzadeh, NN; Vasta, F; Wu, TJ1
Byagowi, S; Darabi, M; Fayezi, S; Mirshahvaladi, S; Sahmani, M1
Gong, XD; Guo, YH; Jiang, B; Shi, J; Wang, JY; Yuan, HH1
Li, B; Li, Y; Zeng, M; Zhang, C; Zhang, J; Zheng, Z1
Cao, H; Dubé, PE; Hao, X; Liu, L; Lu, N; Polk, DB; Ren, X; Rosen, MJ; Van Kaer, L; Wang, L; Washington, MK; Wilson, KT; Yan, F1
Angelini, M; Benaiteau, F; Fleury, F; Gyulkhandanyan, A; Gyulkhandanyan, L; Le Béchec, M; Lecocq, MF; Logé, C; Reiter, E; Roussakis, C; Rousseau, B; Sakanyan, V1
Chan, TA; Luwor, RB; Mariadason, JM; Ng, I; Putoczki, TL; Stylli, SS; Ung, N; Zhu, HJ1
Grazide, MH; Josse, G; Larroque-Cardoso, P; Mucher, E; Nadal-Wolbold, F; Nègre-Salvayre, A; Salvayre, R; Schmitt, AM; Zarkovic, K1
Carter, RL; Grisanti, LA; Houser, SR; Makarewich, CA; Radcliffe, SW; Repas, AA; Talarico, JA; Tang, HA; Tilley, DG; Yu, JE1
Abu-Humaidan, AH; Alberius, P; Ananthoju, N; Garred, P; Mohanty, T; Schmidtchen, A; Sonesson, A; Sørensen, OE1
Allolio, B; Buck, AK; Germer, CT; Lorenz, U; Ritter, CO; Wiegering, A1
Harada, H; Kojima, S; Takai, E; Tsukimoto, M1
Borgmann, D; Höglinger, O; Lanzerstorfer, P; Schütz, G; Weghuber, J; Winkler, SM1
Chen, C; Gao, Z; Kang, H; Li, J; Rong, G; Zhang, L; Zhang, X1
Babaeva, E; Gradinaru, I; Kleine-Brueggeney, M; Oganesian, A; Schwinn, DA1
Han, D; Sun, J; Wang, F; Xiao, W; Zhu, Y1
Amore, E; Azzolina, A; Bondì, ML; Botto, C; Cervello, M; Craparo, EF; Giammona, G1
Cai, Q; Hong, S; Jiang, W; Xu, C; Yu, Y; Zhang, M; Zhang, X1
Jiang, Y; Pan, X; Sun, C; Wang, Q; Xiao, W; Yang, Z; Zhang, Y; Zhu, M1
Dayton, WR; Kamanga-Sollo, E; Pampusch, MS; Reiter, BC; White, ME1
Bondesson, M; Hans, C; Harris, PS; Hemmer, MJ; Kleinstreuer, N; Knudsen, TB; McCollum, CW; Merchant, FA; Olin, J; Padilla, S; Shah, S; Tal, TL; Wood, CE1
Beaty, BT; Condeelis, JS; Cox, D; Eddy, RJ; Sharma, VP1
Kakudo, K; Minamino, Y; Nozaki, M; Ohnishi, Y1
Dong, CS; Li, JH; Liu, QL; Liu, RJ; Luo, BH; Luo, GQ; Wang, JP; Wang, KS; Wen, JF; Xiao, H; Xiao, N; Xie, B; Xiong, F; Yang, XJ; Zhong, M1
Ariff, MA; Mathivanan, P; Parker, R; Rudra, T; Taub, M1
Djordjevic, J; Dobutovic, B; Isenovic, ER; Jevremovic, D; Jovanovic, A; Marche, P; Obradovic, M; Smiljanic, K1
Pandya, CD; Pillai, A1
Davies, MG; Duru, EA; Fu, Y1
Fujiki, K; Inamura, H; Matsuoka, M1
Han, J; Jeon, M; Jung, T; Kil, WH; Kim, S; Lee, J; Lee, JE; Nam, SJ; Oh, SJ1
Brechbuhl, HM; Li, B; Reynolds, SD; Smith, RW1
Chen, JJ; Cui, ZM; Fan, JB; Liu, W; Xu, DW; Yuan, K; Zhu, XH1
Bi, LL; Chen, YH; Gao, TM; Geng, F; Li, XW; Liu, F; Liu, JH; Lu, YS; Mei, L; Sun, XD; Wang, J; Zhang, J; Zhang, M1
Bal de Kier Joffé, E; Pontiggia, O; Raffo, D; Simian, M1
Chen, Q; Liu, W; Wang, C; Xia, G; Yang, Y; Zhang, M; Zhang, W1
Kimura, M; Moteki, H; Ogihara, M1
He, X; Kong, Y; Li, W; Xiao, M; Zhang, H1
Gao, Q; Gong, C; Jin, P; Liu, Y; Ma, D; Wei, X; Xu, S; Yang, Z; Zhang, T; Zhou, X1
Dong, A; Lowe, AW; Wodziak, D1
Bi, Y; Cao, Y; Wei, Z; Yu, D1
Hu, J; Li, X; Liang, D; Liang, G; Lin, F; Qian, Y; Wang, J; Xu, Z; Zeng, C; Zhong, P1
Barosso, IR; Boaglio, AC; Crocenzi, FA; Miszczuk, GS; Roma, MG; Sánchez Pozzi, EJ; Taborda, DR; Zucchetti, AE1
Kamezaki, A; Kawakami, K; Sakaguchi, K; Sato, F; Sato, T; Sehara-Fujisawa, A; Tanigome, R1
Kolybo, DV; Komisarenko, SV; Korotkevych, NV; Labyntsev, AJ1
Ait-Aissa, K; Ali, M; Kassan, M; Matrougui, K; Trebak, M1
Bailie, K; Bell, J; Comer, D; Douglas, I; Heaney, LG; Parker, JC; Shields, MD; Skibinski, G1
Denny, EC; Kane, SE1
Garófalo, A; Giai, C; Gómez, MI; Gonzalez, CD; Ledo, C1
Appleton, CT; Beier, F; Mort, JS; Pest, MA; Pitelka, V; Usmani, SE1
Li, CY; Li, X; Liu, JL; Qu, WS; Tian, DS; Wang, W; Xie, MJ1
Adamczyk, A; Bojko, A; Cierniak, A; Ligeza, J1
Chang, FR; Chen, IH; Hsieh, PW; Shih, HC; Wu, CC; Wu, YC1
Bodiga, S; Bodiga, VL; Thokala, S; Vemuri, PK1
Dayton, WR; Kamange-Sollo, E; Thornton, KJ; White, ME1
Garay, E; García-Carrancá, A; Martínez-Ramírez, AS; Vázquez-Cuevas, FG1
Chen, K; Cheng, P; Gao, S; Hu, S; Huang, H; Sun, X; Yu, W1
Peng, Z; Shi, H; Wang, J; Xie, Y1
Fukuda, T; Gu, J; Hang, Q; Hou, S; Im, S; Isaji, T1
Li, X; Liang, G; Liu, Z; Peng, K; Qian, Y; Skibba, M; Tian, X; Wang, J; Xu, Z; Zou, C1
Chopp, M; Elias, SB; Li, Y; Lu, M; Zhang, J; Zhang, Y; Zhang, ZG1
Cai, MX; Chen, T; Du, SJ; Lin, QQ; Shi, XC; Tan, ZN; Tian, ZJ1
Sui, JQ; Xie, KP; Xie, MJ1
Boerner, J; Joiakim, A; Mathieu, PA; Reiners, JJ; Shelp, C1
Ma, Y; Shi, H; Yi, Y; Zhang, T1
Fang, Q; Li, W; Li, X; Liang, G; Lin, F; Wang, L; Wang, Y; Zhang, Y; Zheng, C; Zhong, P; Zou, C1
Akhtar, S; Al-Zaid, B; Attur, S; Benter, IF; Chandrasekhar, B; El-Hashim, AZ1
Fan, Z; Lu, Y; Qiu, S; Shi, C1
Jiang, J; Tang, X; Wang, Y; Yao, Y; Zhou, J1
Fujimoto, M; Imanaka-Yoshida, K; Kawakita, F; Liu, L; Nakasaki, A; Shiba, M; Shimojo, N; Suzuki, H; Yoshida, T1
Chen, L; Fang, Q; Li, W; Li, X; Liang, G; Wang, J; Wang, L; Wang, Y; Zhang, Y; Zhong, P1
Clayton, AH; Khattab, M; Wang, F1
Chen, G; Hossain, MM; Hu, B; Meng, X; Sun, Y; Zhang, X1
Akhtar, S; Alsaeid, M; Dhaunsi, GS1
Banerji, A; Bose, C; Kumar, GB; Nair, BG; Omanakuttan, A; Pandurangan, N1
Dorobantu, CM; Harak, C; Klein, R; Lohmann, V; Strating, JR; van der Linden, L; van der Schaar, HM; van Kuppeveld, FJ1
Bao, Y; Hu, J; Lan, J; Li, X; Liang, G; Peng, K; Qian, Y; Skibba, M; Zhao, Y; Zhong, P1
Harder, J; Mildner, M; Rademacher, F; Schröder, L; Simanski, M1
Amatngalim, GD; Hiemstra, PS; Scholte, BJ; Stolarczyk, M; Veltman, M; Yu, X1
Chen, HC; Dou, BB; Fu, JY; Liu, WT; Miao, L; Tan, C; Wang, XR; Yang, B; Yang, RC; Yang, XP; Zhang, T1
Basin, MF; Dong, A; Lowe, AW; Wodziak, D1
Lang, B; Meng, LR; Shang, C1
Chang, HM; Cheng, JC; Leung, PC; So, WK; Xiong, S1
Gao, DP; Gao, R; Ji, MH; Shen, JC; Yang, JJ; Yang, RH; Zhang, SG1
Fulton, AM; Kochel, TJ; Kundu, N; Ma, X; Reader, JC1
Heath, JK; Pike, JA; Rappoport, JZ; Styles, IB1
Baba, Y; Fujii, M; Kato, Y; Maeda, T; Suzuki, A; Takada, S1
Chen, B; Chicoine, LG; Jin, Y; Liu, Y; Nelin, LD; White, HA1
García-Sáinz, JA; Hirasawa, A; Takei, Y; Tsujimoto, G; Villegas-Comonfort, S1
Jin, J; Lai, W; Lin, Q; Shao, G; Shao, Q; Wan, X; Wei, Y; Xue, J; Zhang, L; Zou, S1
Han, J; Liang, G; Qian, Y; Wang, J; Weng, Q; Xu, Z; Zhao, Y; Zhong, P; Zou, C1
Nakajima, M; Nozaki, M; Ohnishi, Y; Yasui, H1
Chen, H; Dong, L; Feng, Z; Hu, J; Liang, G; Liu, Z; Shan, X; Wang, W; Wu, B; Wu, L; Xu, T; Zhang, Y1
Bordignon, V; da Rosa, PRA; De Cesaro, MP; Duggavathi, R; Gonçalves, PBD; Pereira Dau, AM1
Cai, L; Chen, X; He, J; Lan, P; Li, L; Li, X; Zhang, X1
Akhtar, S; Babyson, RS; Benter, IF; El-Hashim, AZ; Ezeamuzie, C; Khajah, MA; Renno, WM; Uddin, M1
Chen, H; Hu, J; Liang, D; Liang, G; Liu, Z; Wang, J; Wang, W; Zhang, W; Zhao, L; Zhong, P1
Ahn, HJ; Bhatt, L; Kim, YH; Lee, WK; Nam, HW; Yang, Z1
Kouzaki, H; Ogawa, T; Shimizu, S; Shimizu, T; Takezawa-Yasuoka, K; Tojima, I1
Huang, TW; Li, ST; Young, TH1
Han, G; Heaps, CL; Stallone, JN; Yu, X1
Araldi, D; Ferrari, LF; Levine, JD1
Beaulieu Leclerc, V; Proulx, S; Roy, O; Santerre, K1
Araujo Vieira, I; Brufatto Olguins, D; Brunetto de Farias, C; José Gregianin, L; Kersting, N; Kunzler Souza, B; Lunardi Brunetto, A; Pereira Dos Santos, R; Roesler, R; Schwartsmann, G; Tesainer Brunetto, A1
Gao, MY; Lin, C; Qin, Y; Wang, YF; Zhang, H1
Gao, H; Gui, S; Jin, L; Kang, J; Liu, Q; Yuan, T; Zhang, J; Zhang, Y1
Han, J; Jiang, L; Jin, Z; Lou, D; Qian, Y; Xu, J; Yang, Y; Yu, Q; Zhou, L1
Akin, JW; Brännström, M; Choi, Y; Curry, TE; Jo, M; Rosewell, KL1
Chen, H; Ju, X; Song, Z; Wang, Y; Wu, W; Yan, T; Yang, X; Zhang, Z1
Li, J; Liu, Y; Lu, J; Peng, Z; Zhang, L1
Kanamura, N; Marunaka, R; Marunaka, Y; Taruno, A; Yamamoto, T1
Kanamaru, H; Kawakita, F; Liu, L; Nakano, F; Nakatsuka, Y; Nishikawa, H; Okada, T; Pak, S; Shiba, M; Suzuki, H1
Chen, XW; Geng, F; Liu, JY; Lu, GF; Peng, C; Rodriguez, G; Tian, J; Wu, JL; Zou, WJ1
Deng, Q; Li, B; Li, P; Liu, H; Liu, J; Wei, Z; Yan, J; Zhang, Z1
Barros Nunes, G; Chediek Dall'Acqua, P; Fábio Gouveia Nogueira, M; Fontes, PK; Lombardi Lopes, F; Marinho, M; Rodrigues da Silva, C; Zoccal Mingoti, G1
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Liu, B; Tian, T; Yang, B; Yao, Y; Zhang, K1
Chen, R; Hei, Y; Liu, W; Long, Q; Mao, X; Wang, J1
Bajo, AM; Carmena, MJ; Muñoz-Moreno, L; Prieto, JC; Schally, AV1
Dai, H; Jia, G; Wang, R; Yue, Y1
Chen, L; Du, L; Li, H; Xie, S; Zhang, L; Zhang, X1
Azuma, M; Kim, M; Ko, S; Lee, DA; Lee, SH; Park, H; Parsons, MJ; Prober, D; Shin, D; So, J1
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Huang, J; Ji, D; Lei, H; Li, H; Rong, R; Tang, L; Wu, J; Wu, W; Xia, X; Xiong, K; You, M; Zeng, Z1
Akashi, M; Fukuoka, T; Hasegawa, T; Kakei, Y; Kashin, M; Sasaki, R; Teraoka, S; Yamaguchi, A1
Felder, RB; Wei, SG; Yu, Y1
Chen, Z; Hu, R; Jiang, H; Sun, Y; Yan, J; Yang, Y1
Bian, X; Li, X; Sun, Y; Tian, W; Tian, Y; Xu, J; Zhao, H1
Chu, HW; Davis-Hall, D; Dobrinskikh, E; Magin, CM; Michalski, JE; Park, JA; Schwartz, DA; Smith, BJ; Stancil, IT; Yang, IV1
Hu, R; Jiang, H; Li, W; Sun, Y; Wang, Z; Yan, J; Yang, Y1
Akudugu, JM; Hamid, MB; Serafin, AM1
Bondy, C; Chen, Y; Luo, Q; Wang, J; Zhou, X; Zhu, L1

Reviews

3 review(s) available for rtki cpd and quinazolines

ArticleYear
Aberrant receptor signaling in human malignant gliomas: mechanisms and therapeutic implications.
    Cancer letters, 2001, Volume: 162 Suppl

    Topics: Apoptosis; Drug Resistance, Neoplasm; ErbB Receptors; Glioma; Humans; Mutation; Quinazolines; Signal Transduction; Tyrphostins

2001
The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.
    Oncogene, 2001, Mar-15, Volume: 20, Issue:11

    Topics: Autocrine Communication; Benzothiazoles; Breast Neoplasms; Carcinoma; Epidermal Growth Factor; ErbB Receptors; Female; Genes, erbB; Growth Substances; Humans; Neuregulin-1; Quinazolines; Radiation, Ionizing; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2001
Modulation of the oncogene-dependent tissue factor expression by kinase suppressor of ras 1.
    Thrombosis research, 2010, Volume: 126, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Factor VIIa; Genes, ras; Humans; Mice; Mice, SCID; Morpholines; Neoplasms; Oncogenes; Phosphotransferases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Thromboplastin; Trastuzumab; Tyrphostins; Up-Regulation

2010

Other Studies

719 other study(ies) available for rtki cpd and quinazolines

ArticleYear
Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors.
    Cancer research, 1996, Sep-01, Volume: 56, Issue:17

    Topics: Benzylidene Compounds; Cell Division; Enzyme Inhibitors; ErbB Receptors; Gene Amplification; Glioma; Humans; Mutation; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrphostins

1996
Inhibition of gastric mucosal regeneration by tyrphostin: evaluation of the role of epidermal growth factor receptor tyrosine kinase.
    The Journal of laboratory and clinical medicine, 1996, Volume: 128, Issue:2

    Topics: Animals; Benzylidene Compounds; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Male; Mucous Membrane; Nitriles; Proliferating Cell Nuclear Antigen; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Inbred F344; Regeneration; Stomach; Tyrphostins

1996
Growth inhibition of human lung adenocarcinoma cells by antibodies against epidermal growth factor receptor and by ganglioside GM3: involvement of receptor-directed protein tyrosine phosphatase(s).
    British journal of cancer, 1997, Volume: 75, Issue:2

    Topics: Adenocarcinoma; Benzylidene Compounds; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Membrane; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Humans; Lung Neoplasms; Nitriles; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Radioligand Assay; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

1997
Inhibition of tyrosine kinase activity decreases expression of surfactant protein A in a human lung adenocarcinoma cell line independent of epidermal growth factor receptor.
    Biochimica et biophysica acta, 1997, Mar-01, Volume: 1355, Issue:3

    Topics: Benzylidene Compounds; Binding, Competitive; Blotting, Northern; Blotting, Western; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Lung; Lung Neoplasms; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinazolines; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins

1997
Opposing effects of tyrosine kinase inhibitors on mineralization of normal and tumor bone cells.
    Journal of cellular biochemistry, 1997, Jun-01, Volume: 65, Issue:3

    Topics: Alkaline Phosphatase; Animals; Benzylidene Compounds; Bone Marrow; Bone Neoplasms; Calcification, Physiologic; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Nitriles; Osteosarcoma; Protein-Tyrosine Kinases; Quinazolines; Rats; Stem Cells; Stromal Cells; Tumor Cells, Cultured; Tyrphostins

1997
Tyrphostin AG 494 blocks Cdk2 activation.
    FEBS letters, 1997, Jun-30, Volume: 410, Issue:2-3

    Topics: 3T3 Cells; Acrylamides; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Mice; Molecular Structure; Nitriles; Protein Serine-Threonine Kinases; Quinazolines; Tyrphostins

1997
Two- and three-dimensional cell structures govern epidermal growth factor survival function in human bladder carcinoma cell lines.
    Cancer research, 1997, Aug-15, Volume: 57, Issue:16

    Topics: Apoptosis; Culture Media, Serum-Free; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Neoplasm Proteins; Nitriles; Protein-Tyrosine Kinases; Quinazolines; Spheroids, Cellular; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Urinary Bladder Neoplasms

1997
Unliganded epidermal growth factor receptor dimerization induced by direct interaction of quinazolines with the ATP binding site.
    The Journal of biological chemistry, 1997, Sep-12, Volume: 272, Issue:37

    Topics: Adenosine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Binding Sites; Carrier Proteins; Dimerization; Enzyme Inhibitors; ErbB Receptors; Glycoproteins; Humans; Ligands; Neuregulin-1; Nitriles; Phosphorylation; Protein Binding; Protein Conformation; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

1997
Inhibitors of epidermal growth factor receptor kinase and of cyclin-dependent kinase 2 activation induce growth arrest, differentiation, and apoptosis of human papilloma virus 16-immortalized human keratinocytes.
    Cancer research, 1997, Sep-01, Volume: 57, Issue:17

    Topics: Antibodies; Apoptosis; Benzylidene Compounds; Cell Cycle; Cell Differentiation; Cell Division; Cell Line, Transformed; Cyclin-Dependent Kinases; Enzyme Inhibitors; ErbB Receptors; Filaggrin Proteins; Humans; Keratinocytes; Nitriles; Papillomaviridae; Phosphorylation; Quinazolines; Tyrphostins

1997
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation.
    Oncogene, 1997, Sep-04, Volume: 15, Issue:10

    Topics: Breast Neoplasms; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cell Division; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Inositol 1,4,5-Trisphosphate; Isoenzymes; Nitriles; Phospholipase C gamma; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; Quinazolines; Radiation, Ionizing; Receptor Protein-Tyrosine Kinases; Signal Transduction; Tumor Cells, Cultured; Type C Phospholipases; Tyrphostins

1997
EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 2

    Topics: Animals; Aprotinin; Cell Line; Coculture Techniques; Collagen; Cysteine Proteinase Inhibitors; Embryonic Induction; Enzyme Inhibitors; Epithelium; ErbB Receptors; Hepatocyte Growth Factor; Kidney; Kidney Medulla; Kidney Tubules, Collecting; Leucine; Ligands; Mice; Mice, Knockout; Morphogenesis; Nitriles; Phenanthrolines; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Quinazolines; Receptor Protein-Tyrosine Kinases; Transforming Growth Factor alpha; Tyrphostins

1997
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.
    The Biochemical journal, 1997, Oct-01, Volume: 327 ( Pt 1)

    Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Androstadienes; Aspartic Acid Endopeptidases; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Inositol; Inositol Phosphates; Maleimides; Nitriles; Phosphatidylinositols; Phosphotyrosine; Protein Kinase C; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Wortmannin

1997
Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activated ras-stimulated intestinal epithelial cells.
    International journal of cancer, 1997, Dec-10, Volume: 73, Issue:6

    Topics: Amphiregulin; Animals; Apoptosis; Autocrine Communication; Betacellulin; Cell Division; Cells, Cultured; Chlorates; Culture Media, Conditioned; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Nitriles; Phosphorylation; Polysaccharide-Lyases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; ras Proteins; Rats; RNA; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation

1997
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor.
    The Journal of clinical investigation, 1998, Jan-15, Volume: 101, Issue:2

    Topics: 3T3 Cells; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Carcinoma, Squamous Cell; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Decorin; Enzyme Activation; ErbB Receptors; Extracellular Matrix Proteins; Humans; Mice; Nitriles; Phosphorylation; Proteoglycans; Quinazolines; Tumor Cells, Cultured; Tyrphostins

1998
Constitutive activation of c-Jun N-terminal kinase by a mutant epidermal growth factor receptor.
    The Journal of biological chemistry, 1998, Jan-30, Volume: 273, Issue:5

    Topics: 3T3 Cells; Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Down-Regulation; Enzyme Activation; ErbB Receptors; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Transfection; Tyrphostins

1998
Decorin activates the epidermal growth factor receptor and elevates cytosolic Ca2+ in A431 carcinoma cells.
    The Journal of biological chemistry, 1998, Feb-06, Volume: 273, Issue:6

    Topics: Calcium; Cell Division; Cytosol; Decorin; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Humans; Nitriles; Proteoglycans; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

1998
Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells.
    The Journal of biological chemistry, 1998, Apr-10, Volume: 273, Issue:15

    Topics: Adaptor Proteins, Signal Transducing; Angiotensin II; Animals; Aorta, Thoracic; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GRB2 Adaptor Protein; Muscle, Smooth, Vascular; Nitriles; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; Rats, Sprague-Dawley; src Homology Domains; Tyrphostins

1998
Effect of tyrosine kinase inhibition on surfactant protein A gene expression during human lung development.
    The American journal of physiology, 1998, Volume: 274, Issue:4 Pt 1

    Topics: Embryonic and Fetal Development; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genistein; Homeostasis; Humans; Lung; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinazolines; RNA, Messenger; Tyrosine; Tyrphostins

1998
Drug resistance of human glioblastoma cells conferred by a tumor-specific mutant epidermal growth factor receptor through modulation of Bcl-XL and caspase-3-like proteases.
    Proceedings of the National Academy of Sciences of the United States of America, 1998, May-12, Volume: 95, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; Caspase 3; Caspases; Cisplatin; Cysteine Endopeptidases; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; ErbB Receptors; Glioblastoma; Humans; Nitriles; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tumor Cells, Cultured; Tyrphostins

1998
Endothelin-1 stimulates DNA synthesis of vascular smooth-muscle cells through transactivation of epidermal growth factor receptor.
    Journal of cardiovascular pharmacology, 1998, Volume: 31 Suppl 1

    Topics: Animals; Biotransformation; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; DNA; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Male; Muscle, Smooth, Vascular; Nitriles; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-fos; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins

1998
Activation of NF-kappa B by oncogenic Raf in HEK 293 cells occurs through autocrine recruitment of the stress kinase cascade.
    Oncogene, 1998, Aug-13, Volume: 17, Issue:6

    Topics: 3T3 Cells; Animals; Autocrine Communication; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; ErbB Receptors; Gene Expression Regulation; Genes, Reporter; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinases; Mutation; NF-kappa B; Nitriles; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Suramin; Tyrphostins

1998
Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation.
    The Journal of biological chemistry, 1998, Sep-04, Volume: 273, Issue:36

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 2; GTP-Binding Proteins; Ionomycin; Models, Biological; Nitriles; PC12 Cells; Phorbol Esters; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Quinazolines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Tyrphostins; Ubiquitin-Protein Ligases; Uridine Triphosphate

1998
Opposing effects of cyclosporin A and tyrphostin AG-1478 indicate a role for Src protein in the cellular control of mineralization.
    Journal of cellular biochemistry, 1998, Oct-01, Volume: 71, Issue:1

    Topics: Animals; Calcification, Physiologic; Cell Differentiation; Cells, Cultured; Cyclosporine; Dexamethasone; Enzyme Inhibitors; Female; Phosphorylation; Proteins; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; Rats, Inbred Strains; Stromal Cells; Tyrosine; Tyrphostins

1998
Epidermal growth factor (EGF) modulates fetal thymocyte growth and differentiation: partial reversal by insulin, mimicking by specific inhibitors of EGF receptor tyrosine kinase activity, and differential expression of CD45 phosphatase isotypes.
    Journal of immunology (Baltimore, Md. : 1950), 1998, Oct-01, Volume: 161, Issue:7

    Topics: Animals; Cell Differentiation; Cell Division; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fetus; Growth Inhibitors; Immunophenotyping; Insulin; Isoenzymes; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Molecular Mimicry; Nitriles; Organ Culture Techniques; Quinazolines; Solubility; T-Lymphocyte Subsets; Thymus Gland; Tyrphostins

1998
Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion.
    The Journal of biological chemistry, 1998, Oct-16, Volume: 273, Issue:42

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Biological Transport; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Chlorides; Colon; ErbB Receptors; GRB2 Adaptor Protein; Intestinal Mucosa; Phosphorylation; Protein Binding; Protein Kinase C; Proteins; Quinazolines; Receptor, Muscarinic M3; Receptors, Muscarinic; Shc Signaling Adaptor Proteins; Signal Transduction; Transcriptional Activation; Tyrphostins

1998
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells.
    International journal of cancer, 1998, Oct-29, Volume: 78, Issue:3

    Topics: Acute-Phase Proteins; Animals; bcl-X Protein; Cell Line; Cell Survival; Cell Transformation, Neoplastic; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Intestinal Mucosa; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Rats; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrphostins

1998
Chronic ethanol consumption disrupts complexation between EGF receptor and phospholipase C-gamma1: relevance to impaired hepatocyte proliferation.
    Biochemical and biophysical research communications, 1999, Apr-02, Volume: 257, Issue:1

    Topics: Animals; Calcium Signaling; Cell Division; Cells, Cultured; Cytoskeleton; Cytosol; DNA; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Ethanol; Isoenzymes; Liver; Male; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; Quinazolines; Rats; Rats, Wistar; Type C Phospholipases; Tyrphostins

1999
ERK MAP kinase activation is required for acetylcholine receptor inducing activity-induced increase in all five acetylcholine receptor subunit mRNAs as well as synapse-specific expression of acetylcholine receptor epsilon-transgene.
    Brain research. Molecular brain research, 1999, Apr-06, Volume: 67, Issue:1

    Topics: Androstadienes; Animals; Antibiotics, Antineoplastic; Blotting, Northern; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Lac Operon; Mice; Muscle Fibers, Skeletal; Phosphatidylinositol 3-Kinases; Quinazolines; Receptors, Cholinergic; RNA, Messenger; Sirolimus; Synapses; Transcription, Genetic; Transgenes; Tyrphostins; Up-Regulation; Wortmannin

1999
Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
    The Journal of biological chemistry, 1999, May-14, Volume: 274, Issue:20

    Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; ErbB Receptors; Focal Adhesion Kinase 2; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oligopeptides; PC12 Cells; Peptide Fragments; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; src-Family Kinases; Tyrphostins

1999
Differential involvement of Galpha12 and Galpha13 in receptor-mediated stress fiber formation.
    The Journal of biological chemistry, 1999, Jun-18, Volume: 274, Issue:25

    Topics: Actins; Animals; Calcium; Cyclic AMP; Cytoskeleton; ErbB Receptors; Fibroblasts; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Proteins; Ligands; Lysophospholipids; Mice; Mice, Knockout; Microinjections; Proto-Oncogene Proteins; Quinazolines; Receptors, Cell Surface; Signal Transduction; Thrombin; Tyrphostins

1999
4-hydroxynonenal triggers an epidermal growth factor receptor-linked signal pathway for growth inhibition.
    Journal of cell science, 1999, Volume: 112 ( Pt 14)

    Topics: Aldehydes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Division; Cell Line; Cross-Linking Reagents; Enzyme Activation; ErbB Receptors; Genistein; Humans; Lipid Peroxidation; Oxidative Stress; Phosphoproteins; Phosphorylation; Quinazolines; Signal Transduction; Tyrosine; Tyrphostins

1999
Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats.
    The American journal of pathology, 1999, Volume: 155, Issue:1

    Topics: Animals; Collagen; Enzyme Inhibitors; ErbB Receptors; Lung; Mitosis; Phosphorylation; Pulmonary Fibrosis; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Tyrphostins

1999
Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro.
    Journal of cancer research and clinical oncology, 1999, Volume: 125, Issue:7

    Topics: Antineoplastic Agents; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Colorectal Neoplasms; DNA, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Humans; Membrane Proteins; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

1999
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells.
    Biochemical and biophysical research communications, 1999, Jul-14, Volume: 260, Issue:3

    Topics: Adenocarcinoma; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

1999
Nitric oxide inhibits angiotensin II-induced activation of the calcium-sensitive tyrosine kinase proline-rich tyrosine kinase 2 without affecting epidermal growth factor receptor transactivation.
    The Journal of biological chemistry, 1999, Aug-20, Volume: 274, Issue:34

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Angiotensin II; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; ErbB Receptors; Focal Adhesion Kinase 2; Indoles; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nitric Oxide; Nitroprusside; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Quinazolines; Rats; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcriptional Activation; Tyrphostins

1999
Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.
    The Journal of cell biology, 1999, Aug-23, Volume: 146, Issue:4

    Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Chromones; Cytochalasin D; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mice; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-3; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Transfection; Tyrphostins

1999
Ionizing radiation stimulates existing signal transduction pathways involving the activation of epidermal growth factor receptor and ERBB-3, and changes of intracellular calcium in A431 human squamous carcinoma cells.
    Journal of receptor and signal transduction research, 1999, Volume: 19, Issue:6

    Topics: Calcium; Carcinoma, Squamous Cell; Enzyme Inhibitors; ErbB Receptors; Estrenes; Humans; Phosphodiesterase Inhibitors; Phosphorylation; Pyrrolidinones; Quinazolines; Receptor, ErbB-3; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

1999
Growth inhibition of psoriatic keratinocytes by quinazoline tyrosine kinase inhibitors.
    The British journal of dermatology, 1999, Volume: 141, Issue:5

    Topics: Animals; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermis; ErbB Receptors; Humans; Keratinocytes; Mice; Psoriasis; Quinazolines; Skin Absorption; Tumor Cells, Cultured; Tyrphostins

1999
Activation of tyrosine kinases by alpha1A-adrenergic and growth factor receptors in transfected PC12 cells.
    The Biochemical journal, 1999, Dec-15, Volume: 344 Pt 3

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Differentiation; Cytoskeletal Proteins; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GRB2 Adaptor Protein; GTP-Binding Proteins; Mitogen-Activated Protein Kinases; Norepinephrine; Paxillin; PC12 Cells; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Receptors, Growth Factor; Receptors, Nerve Growth Factor; Signal Transduction; Transfection; Tyrphostins

1999
Phorbol ester reduces phosphorylation of epidermal growth factor receptor in pancreatic cancer cells by activation of a tyrosine phosphatase.
    Biochemical and biophysical research communications, 1999, Nov-30, Volume: 265, Issue:3

    Topics: Cell Membrane; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Kinetics; Organometallic Compounds; Pancreatic Neoplasms; Phenanthrolines; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tyrphostins

1999
Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line.
    The American journal of physiology, 1999, Volume: 277, Issue:6

    Topics: Animals; Cell Division; Cell Line, Transformed; Chemotaxis; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Matrix; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Genistein; Growth Substances; Hepatocyte Growth Factor; Insulin-Like Growth Factor I; Intestines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Quinazolines; Transforming Growth Factor beta; Type C Phospholipases; Tyrphostins

1999
Intracellular signaling of angiotensin II-induced p70 S6 kinase phosphorylation at Ser(411) in vascular smooth muscle cells. Possible requirement of epidermal growth factor receptor, Ras, extracellular signal-regulated kinase, and Akt.
    The Journal of biological chemistry, 1999, Dec-24, Volume: 274, Issue:52

    Topics: Angiotensin II; Animals; Calcium; CHO Cells; Cricetinae; ErbB Receptors; Muscle, Smooth, Vascular; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; ras Proteins; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases; Serine; Transcriptional Activation; Tyrphostins

1999
Fluid flow-induced tyrosine phosphorylation and participation of growth factor signaling pathway in osteoblast-like cells.
    Journal of cellular biochemistry, 2000, Volume: 76, Issue:4

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blotting, Western; Cell Line; Culture Media; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Gene Expression Regulation; Immediate-Early Proteins; Mice; Mitogen-Activated Protein Kinase 1; Osteoblasts; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Quinazolines; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Stress, Mechanical; Transcription Factors; Tyrosine; Tyrphostins

2000
Mechanical stretch stimulates growth of vascular smooth muscle cells via epidermal growth factor receptor.
    American journal of physiology. Heart and circulatory physiology, 2000, Volume: 278, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium; Cell Division; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GRB2 Adaptor Protein; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Phosphorylation; Physical Stimulation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; Rats; Rats, Sprague-Dawley; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Tyrphostins

2000
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Feb-15, Volume: 97, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clathrin; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; GTP-Binding Proteins; Isoproterenol; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Cell Surface; Transfection; Tyrphostins

2000
A role for bovine herpesvirus 1 (BHV-1) glycoprotein E (gE) tyrosine phosphorylation in replication of BHV-1 wild-type virus but not BHV-1 gE deletion mutant virus.
    Virology, 2000, Mar-01, Volume: 268, Issue:1

    Topics: Animals; Capsid; Cell Line; Dogs; Gene Deletion; Genistein; Herpesvirus 1, Bovine; Mutation; Phosphorylation; Phosphotyrosine; Precipitin Tests; Protein-Tyrosine Kinases; Quinazolines; Tyrphostins; Viral Envelope Proteins; Viral Proteins; Virus Replication

2000
Role of transforming growth factor-alpha and the epidermal growth factor receptor in embryonic rat testis development.
    Biology of reproduction, 2000, Volume: 62, Issue:3

    Topics: Animals; Animals, Newborn; Antibody Specificity; Cell Division; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation, Developmental; Male; Mice; Mice, Knockout; Quinazolines; Rats; Rats, Sprague-Dawley; Testis; Transforming Growth Factor alpha; Tyrphostins

2000
Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines.
    The Journal of urology, 2000, Volume: 163, Issue:3

    Topics: Cell Division; Dihydrotestosterone; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2000
Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity.
    The Journal of biological chemistry, 2000, Mar-10, Volume: 275, Issue:10

    Topics: Animals; Cell Cycle Proteins; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Female; G1 Phase; Humans; Mice; Mice, Inbred BALB C; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Retinoblastoma Protein; Tumor Suppressor Proteins; Tyrphostins; Up-Regulation

2000
The mitogen-activated protein kinase cascade mediates neurotrophic effect of epidermal growth factor in cultured rat hippocampal neurons.
    Neuroscience letters, 2000, Mar-17, Volume: 282, Issue:1-2

    Topics: Animals; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hippocampus; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tyrphostins

2000
Calcium channel antagonist effect on in vitro meningioma signal transduction pathways after growth factor stimulation.
    Neurosurgery, 2000, Volume: 46, Issue:3

    Topics: Adult; Aged; Blood Physiological Phenomena; Calcium; Calcium Channel Blockers; Culture Techniques; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Growth Substances; Humans; Inositol Phosphates; Intracellular Membranes; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Quinazolines; Signal Transduction; Type C Phospholipases; Tyrphostins

2000
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.
    The Journal of biological chemistry, 2000, Mar-24, Volume: 275, Issue:12

    Topics: Animals; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-met; Quinazolines; Rats; Receptor Cross-Talk; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2000
Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC12 cells.
    Archives of biochemistry and biophysics, 2000, Apr-15, Volume: 376, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Nitrates; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Quinazolines; Rats; src-Family Kinases; Tyrphostins

2000
Role of basal calcium in the EGF activation of MAP kinases.
    Oncogene, 2000, Mar-30, Volume: 19, Issue:14

    Topics: Animals; Calcium; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Isoenzymes; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipase C gamma; Protein Tyrosine Phosphatases; Quinazolines; Type C Phospholipases; Tyrphostins

2000
Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src).
    The Journal of biological chemistry, 2000, Apr-28, Volume: 275, Issue:17

    Topics: Calcium; Carbachol; Cell Line; Chlorides; Colon; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; Fluphenazine; Focal Adhesion Kinase 2; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Signal Transduction; Thapsigargin; Time Factors; Transcriptional Activation; Tyrphostins

2000
Mechanism of extracellular signal-regulated kinase (ERK)-1 and ERK-2 activation by vanadium pentoxide in rat pulmonary myofibroblasts.
    American journal of respiratory cell and molecular biology, 2000, Volume: 22, Issue:5

    Topics: Acetylcysteine; Animals; Asthma; Bronchitis; Carbon; Coal Ash; Colforsin; Enzyme Activation; ErbB Receptors; Fibroblasts; Flavonoids; Intracellular Signaling Peptides and Proteins; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Particulate Matter; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Protein Tyrosine Phosphatases; Quinazolines; Rats; Titanium; Tyrphostins; Vanadium Compounds

2000
Activation of epidermal growth factor receptor during corneal epithelial migration.
    Investigative ophthalmology & visual science, 2000, Volume: 41, Issue:6

    Topics: Amphiregulin; Animals; Binding Sites; Cell Movement; Debridement; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium, Corneal; ErbB Receptors; Female; Fluorescent Antibody Technique, Indirect; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Organ Culture Techniques; Phosphorylation; Precipitin Tests; Quinazolines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrphostins; Wound Healing

2000
Receptor tyrosine kinase inhibition suppresses growth of pediatric renal tumor cells in vitro.
    Journal of pediatric surgery, 2000, Volume: 35, Issue:6

    Topics: Adult; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Genistein; Humans; Infant; Kidney Neoplasms; Male; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Quinazolines; Receptor Protein-Tyrosine Kinases; Rhabdoid Tumor; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrphostins; Wilms Tumor

2000
Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor.
    Circulation research, 2000, Jul-21, Volume: 87, Issue:2

    Topics: Animals; Anticoagulants; Aorta; Becaplermin; Cell Line; Cell Movement; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Papio; Phenylalanine; Phosphorylation; Platelet-Derived Growth Factor; Protease Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; Thiophenes; Thrombin; Tyrphostins

2000
Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells.
    Cancer research, 2000, Jul-01, Volume: 60, Issue:13

    Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; Female; HL-60 Cells; Humans; Microtubules; Mitosis; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Tyrphostins

2000
Blockade of the epidermal growth factor receptor tyrosine kinase suppresses tumorigenesis in MMTV/Neu + MMTV/TGF-alpha bigenic mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2000, Aug-15, Volume: 97, Issue:17

    Topics: Animals; Butadienes; CDC2-CDC28 Kinases; Cell Cycle Proteins; Cell Division; Cell Transformation, Neoplastic; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cysteine Endopeptidases; Dimerization; DNA; Down-Regulation; ErbB Receptors; Female; Humans; Mammary Neoplasms, Experimental; Mammary Tumor Virus, Mouse; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nitriles; Phosphorylation; Proteasome Endopeptidase Complex; Protein Serine-Threonine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins

2000
Epidermal growth factor receptor signaling activates met in human anaplastic thyroid carcinoma cells.
    Experimental cell research, 2000, Aug-25, Volume: 259, Issue:1

    Topics: Antineoplastic Agents; Butadienes; Carcinoma; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Nitriles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-met; Quinazolines; RNA, Messenger; Suramin; Thyroid Neoplasms; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2000
Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors.
    The Biochemical journal, 2000, Sep-01, Volume: 350 Pt 2

    Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Cell Line; Cell Membrane; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Norepinephrine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; Staurosporine; Time Factors; Transfection; Tyrphostins; Wortmannin

2000
Thyrotropin-releasing hormone stimulates phosphorylation of the epidermal growth factor receptor in GH3 pituitary cells.
    Molecular endocrinology (Baltimore, Md.), 2000, Volume: 14, Issue:9

    Topics: Animals; Enzyme Inhibitors; ErbB Receptors; Genes, Reporter; Indoles; Luciferases; Maleimides; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Pituitary Neoplasms; Protein Kinase C; Quinazolines; Rats; Recombinant Proteins; Thyrotropin-Releasing Hormone; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrphostins

2000
Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.
    Cancer research, 2000, Sep-15, Volume: 60, Issue:18

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Division; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Ovarian Neoplasms; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proteins; Quinazolines; Receptor, Endothelin A; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Tyrphostins

2000
Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.
    Oncogene, 2000, Sep-21, Volume: 19, Issue:40

    Topics: Alkaline Phosphatase; Biological Transport; Breast Neoplasms; Cell Nucleus; Chromones; Cytoplasm; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Macromolecular Substances; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Quinazolines; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tyrphostins; Ubiquitin-Protein Ligases

2000
Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.
    Cancer research, 2000, Oct-15, Volume: 60, Issue:20

    Topics: Animals; Breast Neoplasms; Butadienes; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogen Receptor Modulators; Female; Gene Expression; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Quinazolines; Receptor, ErbB-2; Receptors, Estrogen; Tamoxifen; Transcription, Genetic; Tyrphostins; Xenograft Model Antitumor Assays

2000
Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression.
    Carcinogenesis, 2000, Volume: 21, Issue:12

    Topics: Amphiregulin; Animals; Betacellulin; Butylhydroxybutylnitrosamine; Carcinogens; Disease Progression; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Tyrphostins

2000
Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation.
    Circulation research, 2001, Jan-19, Volume: 88, Issue:1

    Topics: Angiopoietin-1; Angiopoietin-2; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cells, Cultured; Cornea; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Imidazoles; In Vitro Techniques; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Maleimides; Membrane Glycoproteins; Naphthalenes; Neovascularization, Physiologic; Olmesartan Medoxomil; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proteins; Pyridines; Quinazolines; Rabbits; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, TIE-2; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, TIE; RNA Stability; RNA, Messenger; Tetrazoles; Time Factors; Transcriptional Activation; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2001
A role for decorin in the structural organization of periodontal ligament.
    Laboratory investigation; a journal of technical methods and pathology, 2000, Volume: 80, Issue:12

    Topics: 3T3 Cells; Aging; Animals; Cell Division; Decorin; Enzyme Inhibitors; Extracellular Matrix Proteins; Female; Male; Mice; Mice, Knockout; Microscopy, Electron; Microscopy, Electron, Scanning; Periodontal Ligament; Proteoglycans; Quinazolines; Recombinant Proteins; Transfection; Transforming Growth Factor beta; Tyrphostins

2000
Ceramide-dependent regulation of p42/p44 mitogen-activated protein kinase and c-Jun N-terminal-directed protein kinase in cultured airway smooth muscle cells.
    Cellular signalling, 2000, Volume: 12, Issue:11-12

    Topics: Animals; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Ceramides; Chromones; Enzyme Activation; Guinea Pigs; Isoenzymes; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet-Derived Growth Factor; Precipitin Tests; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Quinazolines; Respiratory System; Signal Transduction; Sphingosine; Tyrphostins

2000
STAT3-mediated constitutive expression of SOCS-3 in cutaneous T-cell lymphoma.
    Blood, 2001, Feb-15, Volume: 97, Issue:4

    Topics: Cell Transformation, Neoplastic; Dimethyl Sulfoxide; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Interferon-alpha; Interferon-gamma; Jurkat Cells; Leukemia-Lymphoma, Adult T-Cell; Mutation; Mycosis Fungoides; Neoplasm Proteins; Protein Biosynthesis; Proteins; Quinazolines; Recombinant Fusion Proteins; Repressor Proteins; RNA, Messenger; RNA, Neoplasm; Sezary Syndrome; Skin Neoplasms; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Trans-Activators; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tyrphostins

2001
N-acetylcysteine inhibits angiotensin ii-mediated activation of extracellular signal-regulated kinase and epidermal growth factor receptor.
    Biochemical and biophysical research communications, 2001, Feb-02, Volume: 280, Issue:4

    Topics: Acetylcysteine; Angiotensin II; Animals; Antioxidants; Blotting, Western; Calcimycin; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Hydrogen Peroxide; Immunoblotting; Ionophores; Male; Mitogen-Activated Protein Kinases; Muscle, Smooth; Phosphorylation; Precipitin Tests; Pyrimidines; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Transcriptional Activation; Tyrphostins

2001
BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.
    Biochemical and biophysical research communications, 2001, Feb-16, Volume: 281, Issue:1

    Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoblotting; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuregulin-1; Organic Chemicals; Phosphorylation; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Recombinant Proteins; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2001
Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.
    International journal of molecular medicine, 2001, Volume: 7, Issue:3

    Topics: Blotting, Western; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Interleukin-1; Keratinocytes; MAP Kinase Signaling System; Matrix Metalloproteinase 1; Models, Biological; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Quinazolines; Time Factors; Tyrphostins

2001
Sphingosine 1-phosphate activates Erk-1/-2 by transactivating epidermal growth factor receptor in rat-2 cells.
    IUBMB life, 2000, Volume: 50, Issue:2

    Topics: 3T3 Cells; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; HeLa Cells; History, Medieval; Humans; Indoles; Lysophospholipids; Maleimides; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Pertussis Toxin; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-raf; Quinazolines; Rats; Signal Transduction; Sphingosine; Time Factors; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella

2000
Tyrosine kinase involvement in renal arteriolar constrictor responses to angiotensin II.
    Hypertension (Dallas, Tex. : 1979), 2001, Volume: 37, Issue:2 Pt 2

    Topics: Angiotensin II; Animals; Enalaprilat; Enzyme Inhibitors; ErbB Receptors; In Vitro Techniques; Male; Microscopy, Video; Perfusion; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Renal Artery; Signal Transduction; Tyrphostins; Vasoconstriction

2001
Activation of endogenous thrombin receptors causes clustering and sensitization of epidermal growth factor receptors of swiss 3T3 cells without transactivation.
    The Journal of cell biology, 2001, Jan-22, Volume: 152, Issue:2

    Topics: 3T3 Cells; Animals; Cell Division; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; GTP-Binding Proteins; Luminescent Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phalloidine; Quinazolines; Receptor Cross-Talk; Receptors, Thrombin; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Thrombin; Transfection; Tyrphostins

2001
c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation.
    The Journal of biological chemistry, 2001, May-11, Volume: 276, Issue:19

    Topics: Adaptor Proteins, Signal Transducing; Animals; Aorta; Benzoquinones; Cells, Cultured; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Genistein; GRB2 Adaptor Protein; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Pyrimidines; Quinazolines; Quinones; Rifabutin; Swine; Transcriptional Activation; Tyrphostins

2001
Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.
    British journal of cancer, 2001, Apr-06, Volume: 84, Issue:7

    Topics: Cell Division; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gastrin-Releasing Peptide; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Quinazolines; Substrate Specificity; Transcription Factor AP-1; Tumor Cells, Cultured; Tyrphostins

2001
Thrombin-induced p38 mitogen-activated protein kinase activation is mediated by epidermal growth factor receptor transactivation pathway.
    British journal of pharmacology, 2001, Volume: 132, Issue:8

    Topics: Blotting, Western; Calcium; Cells, Cultured; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GTP-Binding Proteins; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precipitin Tests; Quinazolines; Signal Transduction; Thrombin; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella

2001
Prevention of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-10A cell line: correlation with increased transforming growth factor alpha production.
    Cancer research, 2001, Apr-15, Volume: 61, Issue:8

    Topics: Apoptosis; Benzothiazoles; Breast; Cell Count; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Polychlorinated Dibenzodioxins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Messenger; Transforming Growth Factor alpha; Tyrphostins

2001
High-performance liquid chromatographic analysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma.
    Journal of chromatography. B, Biomedical sciences and applications, 2001, Apr-15, Volume: 754, Issue:1

    Topics: Animals; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Enzyme Stability; ErbB Receptors; Freezing; Mice; Quinazolines; Reference Standards; Sensitivity and Specificity; Tyrphostins

2001
Bombesin and substance P analogues differentially regulate G-protein coupling to the bombesin receptor. Direct evidence for biased agonism.
    The Journal of biological chemistry, 2001, Jul-27, Volume: 276, Issue:30

    Topics: 3T3 Cells; Animals; Binding Sites; Blotting, Western; Bombesin; Calcium; Cell Line; COS Cells; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; GTP-Binding Proteins; Humans; Ligands; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Models, Theoretical; Pertussis Toxin; Phosphorylation; Protein Binding; Quinazolines; Rats; Receptors, Bombesin; Signal Transduction; Substance P; Time Factors; Tumor Cells, Cultured; Tyrphostins; Virulence Factors, Bordetella

2001
Activation of extracellular-regulated kinases by normal and mutant EGF receptors.
    Biochimica et biophysica acta, 2001, Feb-05, Volume: 1538, Issue:1

    Topics: Dimethyl Sulfoxide; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Mitogen-Activated Protein Kinases; Mutation; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Quinazolines; Tumor Cells, Cultured; Type C Phospholipases; Tyrphostins

2001
Integrins mediate functional pre- and postsynaptic maturation at a hippocampal synapse.
    Nature, 2001, May-17, Volume: 411, Issue:6835

    Topics: Animals; Antigens, CD; Calcium-Binding Proteins; Cell Adhesion; Cells, Cultured; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Genistein; Glutamic Acid; Hippocampus; Integrin beta3; Integrins; Intercellular Signaling Peptides and Proteins; Isoflavones; Membrane Glycoproteins; Models, Neurological; Nerve Tissue Proteins; Neurons; Oligopeptides; Peptides; Platelet Membrane Glycoproteins; Presynaptic Terminals; Protein Subunits; Quinazolines; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Synapses; Synaptotagmin I; Synaptotagmins; Tyrphostins

2001
Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.
    Molecular biology of the cell, 2001, Volume: 12, Issue:5

    Topics: bcl-X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Flavonoids; Humans; In Situ Nick-End Labeling; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins

2001
EGFR tyrosine kinase inhibitor AG1478 inhibits cell proliferation and arrests cell cycle in nasopharyngeal carcinoma cells.
    Cancer letters, 2001, Aug-10, Volume: 169, Issue:1

    Topics: Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; G1 Phase; Growth Inhibitors; Humans; MAP Kinase Signaling System; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinases; Nasopharyngeal Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins; Up-Regulation

2001
Gi-mediated activation of the Syk kinase by the receptor mimetic basic secretagogues of mast cells: role in mediating arachidonic acid/metabolites release.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Jul-01, Volume: 167, Issue:1

    Topics: Animals; Arachidonic Acid; Calcium; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; ErbB Receptors; Exocytosis; GTP-Binding Protein alpha Subunits, Gi-Go; Intracellular Signaling Peptides and Proteins; Mast Cells; Mitogen-Activated Protein Kinases; p-Methoxy-N-methylphenethylamine; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Wistar; Receptors, IgE; src-Family Kinases; Syk Kinase; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella

2001
Activation of the EGF receptor signaling pathway in airway epithelial cells exposed to Utah Valley PM.
    American journal of physiology. Lung cellular and molecular physiology, 2001, Volume: 281, Issue:2

    Topics: Air Pollutants, Occupational; Bronchi; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Interleukin-8; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Metallurgy; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Quinazolines; Respiratory Mucosa; RNA, Messenger; Signal Transduction; Tyrphostins; Utah

2001
EGF receptor-ERK pathway is the major signaling pathway that mediates upregulation of aldose reductase expression under oxidative stress.
    Free radical biology & medicine, 2001, Jul-15, Volume: 31, Issue:2

    Topics: Aldehyde Reductase; Animals; Cell Line; Cell Survival; Diabetes Complications; Diabetes Mellitus; ErbB Receptors; Flavonoids; Free Radical Scavengers; Humans; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Oxidative Stress; Phthalazines; Protein Kinases; Quinazolines; Rats; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation

2001
Extremely low-dose ionizing radiation causes activation of mitogen-activated protein kinase pathway and enhances proliferation of normal human diploid cells.
    Cancer research, 2001, Jul-15, Volume: 61, Issue:14

    Topics: Cell Division; Cell Line; Cell Survival; Diploidy; DNA-Binding Proteins; DNA, Antisense; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; Gene Expression; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins; Quinazolines; Transcription Factors; Tumor Suppressor Protein p53; Tyrphostins

2001
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.
    European journal of biochemistry, 2001, Volume: 268, Issue:15

    Topics: Androstadienes; Animals; Cell-Free System; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Quinazolines; Receptor, Insulin; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Wortmannin

2001
EGF receptor function is required in late G(1) for cell cycle progression induced by bombesin and bradykinin.
    American journal of physiology. Cell physiology, 2001, Volume: 281, Issue:3

    Topics: 3T3 Cells; Animals; Bombesin; Bradykinin; Cell Cycle; Cell Division; Cell Line; Cyclin D1; Cyclin E; DNA; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; G1 Phase; Kinetics; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Quinazolines; Rats; Receptors, Bombesin; Recombinant Proteins; Transfection; Tyrphostins

2001
ErbB2/neu kinase modulates cellular p27(Kip1) and cyclin D1 through multiple signaling pathways.
    Cancer research, 2001, Sep-01, Volume: 61, Issue:17

    Topics: Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Enzyme Activation; Enzyme Inhibitors; G1 Phase; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transcription, Genetic; Transfection; Tumor Cells, Cultured; Tumor Suppressor Proteins; Tyrphostins; Up-Regulation

2001
Human glioblastoma xenografts overexpressing a tumor-specific mutant epidermal growth factor receptor sensitized to cisplatin by the AG1478 tyrosine kinase inhibitor.
    Journal of neurosurgery, 2001, Volume: 95, Issue:3

    Topics: Animals; Brain Neoplasms; Cell Survival; Cisplatin; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Neoplasm Transplantation; Protein Tyrosine Phosphatases; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured; Tyrphostins

2001
Activation of ErbB2 receptor tyrosine kinase supports invasion of endothelial cells by Neisseria meningitidis.
    The Journal of cell biology, 2001, Oct-01, Volume: 155, Issue:1

    Topics: Actins; Bacterial Adhesion; Cell Line; Cortactin; Cytoskeletal Proteins; Endothelium; Enzyme Activation; Enzyme Inhibitors; Fimbriae, Bacterial; Humans; Microfilament Proteins; Microscopy, Fluorescence; Neisseria meningitidis; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptor, ErbB-2; Signal Transduction; src-Family Kinases; Tyrphostins

2001
Transforming growth factor beta1 (TGF-beta1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-alpha signaling.
    Molecular and cellular biology, 2001, Volume: 21, Issue:21

    Topics: Androstadienes; Animals; Blotting, Northern; Blotting, Western; Cell Death; Cell Line; Cell Survival; Cells, Cultured; Chromones; Collagen Type I; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transforming Growth Factor alpha; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins; Wortmannin

2001
Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.
    The Journal of biological chemistry, 2001, Dec-14, Volume: 276, Issue:50

    Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Ligands; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Phenylalanine; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Quinazolines; Signal Transduction; Tetradecanoylphorbol Acetate; Thiophenes; Transcription Factor AP-1; Transcriptional Activation; Tyrphostins

2001
cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells.
    The Journal of biological chemistry, 2001, Dec-21, Volume: 276, Issue:51

    Topics: Antigens, Bacterial; Bacterial Proteins; Cell Line; Enzyme Activation; Epithelial Cells; ErbB Receptors; Gastric Mucosa; Gene Expression Regulation, Bacterial; Helicobacter pylori; Humans; Interleukin-8; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Transcriptional Activation; Tyrphostins

2001
Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands.
    The Journal of biological chemistry, 2002, Jan-04, Volume: 277, Issue:1

    Topics: Antigens, CD; Cell Adhesion; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix Proteins; Humans; Integrin alpha2; Ligands; Quinazolines; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins

2002
Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.
    Journal of the American College of Cardiology, 2001, Nov-01, Volume: 38, Issue:5

    Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channels, L-Type; Cells, Cultured; Cytochalasin D; Drug Evaluation, Preclinical; ErbB Receptors; Focal Adhesion Kinase 2; Mitogen-Activated Protein Kinases; Myocardium; Phosphorylation; Piperidines; Potassium Channel Blockers; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Quinidine; Rats; Rats, Wistar; Tetraethylammonium; Time Factors; Tyrphostins

2001
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation.
    Journal of immunology (Baltimore, Md. : 1950), 2001, Nov-15, Volume: 167, Issue:10

    Topics: Adult; Asthma; Cells, Cultured; Culture Media, Conditioned; Enzyme Inhibitors; Eosinophils; ErbB Receptors; Humans; Hypersensitivity; Middle Aged; Mucin 5AC; Mucins; Phosphorylation; Pulmonary Eosinophilia; Quinazolines; Respiratory Mucosa; RNA, Messenger; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation

2001
Interleukin-13 induces proliferation of human airway epithelial cells in vitro via a mechanism mediated by transforming growth factor-alpha.
    American journal of respiratory cell and molecular biology, 2001, Volume: 25, Issue:6

    Topics: Bronchi; Cell Division; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Humans; Interleukin-13; Models, Biological; Quinazolines; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins

2001
Metabotropic glutamate receptor 5-induced phosphorylation of extracellular signal-regulated kinase in astrocytes depends on transactivation of the epidermal growth factor receptor.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001, Dec-15, Volume: 21, Issue:24

    Topics: Animals; Astrocytes; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Isoenzymes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptides; Phosphatidylinositols; Phospholipase C beta; Phosphorylation; Protein Binding; Protein Subunits; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; src-Family Kinases; Transcriptional Activation; Type C Phospholipases; Tyrphostins

2001
Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway.
    The Journal of biological chemistry, 2002, Feb-22, Volume: 277, Issue:8

    Topics: Animals; Aorta; Arginine; Calcium Signaling; Cells, Cultured; Chromones; Citrulline; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Kinetics; Morpholines; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphoserine; Phosphothreonine; Quinazolines; Signal Transduction; Swine; Tyrphostins

2002
CD95-mediated apoptosis of human glioma cells: modulation by epidermal growth factor receptor activity.
    Brain pathology (Zurich, Switzerland), 2002, Volume: 12, Issue:1

    Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Brain Neoplasms; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Survival; Coumarins; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Fas Ligand Protein; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Glioma; Humans; Membrane Glycoproteins; Oligopeptides; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Serpins; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrphostins; Viral Proteins

2002
TGF-alpha-driven tumor growth is inhibited by an EGF receptor tyrosine kinase inhibitor.
    Biochemical and biophysical research communications, 2002, Jan-11, Volume: 290, Issue:1

    Topics: Animals; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Division; DNA, Complementary; Enzyme Inhibitors; ErbB Receptors; Glioma; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; RNA; RNA, Messenger; Tetracycline; Time Factors; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrosine; Tyrphostins

2002
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling.
    Cancer research, 2002, Jan-01, Volume: 62, Issue:1

    Topics: Apoptosis; Arabidopsis Proteins; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Plant Proteins; Potassium Channels; Quinazolines; Receptor, IGF Type 1; Ribosomal Protein S6 Kinases; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2002
Differential sensitivity of cancer cells to inhibitors of the epidermal growth factor receptor family.
    Oncogene, 2002, Jan-03, Volume: 21, Issue:1

    Topics: Cell Cycle; Cell Line, Transformed; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Drug Resistance, Neoplasm; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Neoplasm Proteins; Neoplasms; Pyrimidines; Quinazolines; Receptor, ErbB-2; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tyrphostins

2002
Regulation of sarcolemmal Na(+)/H(+) exchange by hydrogen peroxide in adult rat ventricular myocytes.
    Cardiovascular research, 2002, Feb-01, Volume: 53, Issue:2

    Topics: Animals; Cells, Cultured; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Genistein; Hydrogen Peroxide; Imidazoles; Immunoblotting; Indoles; Male; Maleimides; Mitogen-Activated Protein Kinases; Myocardium; p38 Mitogen-Activated Protein Kinases; Plant Proteins; Protein Kinase C; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Rats; Rats, Wistar; Sarcolemma; Signal Transduction; Sodium-Hydrogen Exchangers; src-Family Kinases; Tyrphostins

2002
The role of Ral A in epidermal growth factor receptor-regulated cell motility.
    Cancer research, 2002, Feb-15, Volume: 62, Issue:4

    Topics: Animals; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Neoplasm Metastasis; Quinazolines; ral GTP-Binding Proteins; Tumor Cells, Cultured; Tyrphostins; Urinary Bladder Neoplasms

2002
Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes.
    Molecular endocrinology (Baltimore, Md.), 2002, Volume: 16, Issue:3

    Topics: Angiotensin II; Animals; Arsenicals; Cell Line; Concanavalin A; COS Cells; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Hepatocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Quinazolines; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sucrose; Transfection; Tyrphostins

2002
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
    Nature medicine, 2002, Volume: 8, Issue:3

    Topics: Animals; Cell Line; Colonic Neoplasms; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Gastric Mucosa; Genes, src; Humans; Hypertrophy; MAP Kinase Signaling System; Matrix Metalloproteinases; Mitogen-Activated Protein Kinase 1; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Transcriptional Activation; Tyrphostins

2002
Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.
    DNA and cell biology, 2001, Volume: 20, Issue:12

    Topics: Animals; Blotting, Western; Cell Line; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Quinazolines; Ribosomal Protein S6 Kinases; Signal Transduction; Transfection; Tyrosine; Tyrphostins; Ultraviolet Rays

2001
Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts.
    The Journal of biological chemistry, 2002, May-24, Volume: 277, Issue:21

    Topics: Animals; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Leukocyte Elastase; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tropoelastin; Tyrphostins

2002
alpha 2B-adrenergic receptor activates MAPK via a pathway involving arachidonic acid metabolism, matrix metalloproteinases, and epidermal growth factor receptor transactivation.
    The Journal of biological chemistry, 2002, May-31, Volume: 277, Issue:22

    Topics: Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Arachidonic Acid; Bacterial Proteins; Brimonidine Tartrate; Butadienes; Cell Line; Cell Nucleus; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; MAP Kinase Signaling System; Matrix Metalloproteinases; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Nitriles; Pertussis Toxin; Phosphorylation; Protein Binding; Proteins; Quinacrine; Quinazolines; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Swine; Transcriptional Activation; Tyrphostins; Virulence Factors, Bordetella

2002
Direct inhibition of the cloned Kv1.5 channel by AG-1478, a tyrosine kinase inhibitor.
    American journal of physiology. Cell physiology, 2002, Volume: 282, Issue:6

    Topics: Animals; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression; Genistein; Kv1.5 Potassium Channel; Membrane Potentials; Patch-Clamp Techniques; Phenols; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein-Tyrosine Kinases; Quinazolines; Rats; Time Factors; Transfection; Tyrphostins

2002
Beta-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases.
    The Journal of biological chemistry, 2002, Aug-30, Volume: 277, Issue:35

    Topics: Androstadienes; Animals; Cells, Cultured; DNA Replication; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibroblasts; Heart; Isoproterenol; Male; Mitogen-Activated Protein Kinases; Myocardium; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Tyrphostins; Virulence Factors, Bordetella; Wortmannin

2002
Inhibitory effect and its kinetic analysis of tyrphostin AG1478 on recombinant human protein kinase CK2 holoenzyme.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:6

    Topics: Casein Kinase II; Caseins; DNA-Binding Proteins; Enzyme Inhibitors; Guanosine Triphosphate; Holoenzymes; Humans; Kinetics; Protein Serine-Threonine Kinases; Quinazolines; Recombinant Proteins; Tyrphostins

2002
Role of calmodulin in the modulation of the MAPK signalling pathway and the transactivation of epidermal growth factor receptor mediated by PKC.
    FEBS letters, 2002, Apr-24, Volume: 517, Issue:1-3

    Topics: Animals; Calmodulin; Chlorocebus aethiops; COS Cells; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Mitogen-Activated Protein Kinases; Phenylalanine; Protein Kinase C; Quinazolines; ras Proteins; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Thiophenes; Transcriptional Activation; Tyrphostins

2002
Vitamin D inhibits the activation of stress-activated protein kinases by physiological and environmental stresses in keratinocytes.
    The Journal of endocrinology, 2002, Volume: 173, Issue:3

    Topics: Calcitriol; Cell Line; Depression, Chemical; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Hot Temperature; Humans; Hydrogen Peroxide; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Mitogen-Activated Protein Kinases; Osmotic Pressure; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Quinazolines; Sorbitol; Time Factors; Tumor Necrosis Factor-alpha; Tyrphostins

2002
Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion.
    Cancer research, 2002, Jun-15, Volume: 62, Issue:12

    Topics: Animals; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Metalloendopeptidases; Mice; Mice, Nude; Neoplasm Invasiveness; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Serine Endopeptidases; Transfection; Tumor Cells, Cultured; Tyrphostins; Up-Regulation

2002
EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma.
    Cancer cell, 2002, Volume: 1, Issue:5

    Topics: Blotting, Northern; Carcinoma, Hepatocellular; Cell Division; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrin beta1; Liver Neoplasms; Mitogen-Activated Protein Kinases; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinazolines; Receptors, Cell Surface; Receptors, Fibronectin; Receptors, Urokinase Plasminogen Activator; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2002
Antagonistic and agonistic effects of quinazoline tyrosine kinase inhibitors on mutant EGF receptor function.
    International journal of cancer, 2002, Sep-10, Volume: 101, Issue:2

    Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Animals; Cell Division; Cell Line; Cell Size; Cell Transformation, Neoplastic; Dimerization; ErbB Receptors; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Mutation; Neoplasm Invasiveness; Phosphorylation; Proteins; Quinazolines; Tyrphostins

2002
Secretin regulates paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:4

    Topics: Animals; Cell Membrane Permeability; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Electric Impedance; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Gastric Mucosa; Mannitol; Parietal Cells, Gastric; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinazolines; Secretin; src-Family Kinases; Tyrphostins

2002
Interferon-gamma activates EGF receptor and increases TGF-alpha in T84 cells: implications for chloride secretion.
    American journal of physiology. Gastrointestinal and liver physiology, 2002, Volume: 283, Issue:4

    Topics: Antibodies; Blotting, Western; Carbachol; Cell Line; Cell Membrane; Chlorides; Colon; Enzyme Inhibitors; ErbB Receptors; Humans; Immunosorbent Techniques; Interferon-gamma; Intestinal Mucosa; Kinetics; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; src-Family Kinases; Transforming Growth Factor alpha; Tyrphostins

2002
Tyrosine kinases regulate intracellular calcium during alpha(2)-adrenergic contraction in rat aorta.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:4

    Topics: Adrenergic alpha-Agonists; Animals; Aorta; Brimonidine Tartrate; Calcium; Enzyme Inhibitors; Flavonoids; Hypertension; Male; Mitogen-Activated Protein Kinases; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Quinazolines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Tyrphostins

2002
Lyn- and ERK-mediated vs. Ca2+ -mediated neutrophil O responses with thermal injury.
    American journal of physiology. Cell physiology, 2002, Volume: 283, Issue:5

    Topics: Animals; Burns; Calcium; Calcium Channel Blockers; Enzyme Activation; Enzyme Inhibitors; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neutrophils; Phosphorylation; Platelet Membrane Glycoproteins; Protein Kinase C; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Cell Surface; Receptors, G-Protein-Coupled; src-Family Kinases; Tyrphostins

2002
ACh and adenosine activate PI3-kinase in rabbit hearts through transactivation of receptor tyrosine kinases.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 283, Issue:6

    Topics: Acetylcholine; Adenosine; Animals; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Female; Heart; In Vitro Techniques; Male; Myocardium; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins; Vasodilator Agents

2002
Activation of extracellular-regulated kinase by 5-hydroxytryptamine(2A) receptors in PC12 cells is protein kinase C-independent and requires calmodulin and tyrosine kinases.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Animals; Antibodies, Monoclonal; Benzylamines; Calmodulin; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Mitogen-Activated Protein Kinases; PC12 Cells; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Sulfonamides; Tyrphostins

2002
Cholesterol depletion from the plasma membrane triggers ligand-independent activation of the epidermal growth factor receptor.
    The Journal of biological chemistry, 2002, Dec-20, Volume: 277, Issue:51

    Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; beta-Cyclodextrins; Blotting, Western; Cell Membrane; Cholesterol; COS Cells; Cross-Linking Reagents; Culture Media, Serum-Free; Cyclodextrins; Dimerization; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Immunoblotting; Isoenzymes; Ligands; Mass Spectrometry; Membrane Microdomains; Mice; Mitogen-Activated Protein Kinases; Models, Biological; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Binding; Proteins; Quinazolines; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Type C Phospholipases; Tyrosine; Tyrphostins

2002
Angiotensin II triggers EGFR tyrosine kinase-dependent Ca2+ influx in afferent arterioles.
    Hypertension (Dallas, Tex. : 1979), 2002, Volume: 40, Issue:5

    Topics: Angiotensin II; Animals; Arterioles; Calcium; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fluorescent Dyes; Fura-2; In Vitro Techniques; Intracellular Fluid; Kidney; Male; Manganese; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins

2002
Activation of mitogen-activated protein kinase pathway by the antiandrogen hydroxyflutamide in androgen receptor-negative prostate cancer cells.
    Cancer research, 2002, Nov-01, Volume: 62, Issue:21

    Topics: Androgen Antagonists; Cell Division; Cyclin D1; Enzyme Activation; ErbB Receptors; Flutamide; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Receptors, Androgen; Substance Withdrawal Syndrome; Tyrphostins

2002
Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation.
    Cancer research, 2002, Nov-01, Volume: 62, Issue:21

    Topics: Carcinoma, Squamous Cell; Cell Division; Cell Movement; DNA, Neoplasm; Enzyme Inhibitors; ErbB Receptors; GTP-Binding Proteins; Head and Neck Neoplasms; Humans; Lysophospholipids; MAP Kinase Signaling System; Metalloendopeptidases; Phosphorylation; Quinazolines; Receptor, ErbB-2; S Phase; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrphostins

2002
Relationship of EGFR signal-transduction modulation by tyrosine kinase inhibitors to chemosensitivity and programmed cell death in lung cancer cell lines.
    Methods in molecular medicine, 2003, Volume: 74

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Lung Neoplasms; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2003
Proximal events in signaling by plasma membrane estrogen receptors.
    The Journal of biological chemistry, 2003, Jan-24, Volume: 278, Issue:4

    Topics: Animals; Breast Neoplasms; Cattle; Cell Membrane; Cells, Cultured; Dipeptides; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Heterotrimeric GTP-Binding Proteins; Humans; Ligands; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 11; Mitogen-Activated Protein Kinases; Models, Biological; Oligonucleotides, Antisense; Protease Inhibitors; Protein Binding; Protein Structure, Tertiary; Quinazolines; Receptors, Estrogen; Signal Transduction; Structure-Activity Relationship; Transcriptional Activation; Transfection; Tumor Cells, Cultured; Tyrphostins

2003
Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
    American journal of respiratory cell and molecular biology, 2002, Volume: 27, Issue:6

    Topics: Antineoplastic Agents; Arachidonic Acid; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Hydrogen Peroxide; Imidazoles; Ionophores; Lung; MAP Kinase Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phosphorylation; Platelet Activating Factor; Protein Serine-Threonine Kinases; Pyridines; Quinazolines; ras Proteins; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins

2002
4-Hydroxy-2-nonenal enhances fibronectin production by IMR-90 human lung fibroblasts partly via activation of epidermal growth factor receptor-linked extracellular signal-regulated kinase p44/42 pathway.
    Toxicology and applied pharmacology, 2002, Nov-01, Volume: 184, Issue:3

    Topics: Acetylcysteine; Aldehydes; Cell Line; Culture Media, Conditioned; ErbB Receptors; Fibroblasts; Fibronectins; Humans; Imidazoles; Lipid Peroxidation; Lung; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pyridines; Quinazolines; Signal Transduction; Tyrphostins

2002
Internalization of inactive EGF receptor into endosomes and the subsequent activation of endosome-associated EGF receptors. Epidermal growth factor.
    Science's STKE : signal transduction knowledge environment, 2002, Dec-03, Volume: 2002, Issue:161

    Topics: Animals; Breast Neoplasms; Cell Line; Dogs; Endosomes; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Humans; Kidney; Membrane Proteins; Mice; Monensin; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2002
Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:2

    Topics: Animals; Aorta; Blood Pressure; Collagen Type I; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Fibrosis; Flavonoids; In Vitro Techniques; Luciferases; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinases; Promoter Regions, Genetic; Quinazolines; Tyrphostins; Vasoconstriction

2003
Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells.
    Cell and tissue research, 2003, Volume: 311, Issue:1

    Topics: Animals; Anisomycin; Antibody Specificity; Cell Membrane; Cells, Cultured; Connexin 43; Cytoplasm; Diuretics, Osmotic; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Fluorescent Antibody Technique; Liver; Microscopy, Confocal; Osmotic Pressure; Phosphorylation; Protein Synthesis Inhibitors; Quinazolines; Rabbits; Rats; Sorbitol; Tyrphostins

2003
Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb.
    American journal of physiology. Cell physiology, 2003, Volume: 284, Issue:5

    Topics: Base Sequence; Blotting, Western; Caco-2 Cells; DNA; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myb; Quinazolines; Signal Transduction; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type IIb; Symporters; Transcription, Genetic; Tyrphostins

2003
Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells.
    Journal of cellular physiology, 2003, Volume: 194, Issue:3

    Topics: 3T3 Cells; Animals; Bombesin; Bradykinin; Cytoskeletal Proteins; Endothelins; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Stress Fibers; Tyrosine; Tyrphostins; Vasoconstrictor Agents; Vasopressins

2003
Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:6

    Topics: 8,11,14-Eicosatrienoic Acid; Allantois; Animals; Aryl Hydrocarbon Hydroxylases; Cell Division; Cell Line; Chick Embryo; Chorion; Cyclin D1; Cytochrome P-450 CYP2C9; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Humans; Neovascularization, Physiologic; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor Cross-Talk; Tyrphostins

2003
Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.
    Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:3

    Topics: Animals; Blotting, Western; Calcium; Carbachol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Eye Proteins; Lacrimal Apparatus; Male; Peroxidase; Phenylephrine; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrphostins

2003
P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation.
    Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:3

    Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Cell Division; Cells, Cultured; DNA; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Quinazolines; Receptors, Platelet-Derived Growth Factor; Receptors, Purinergic P2; Tyrphostins

2003
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
    Radiation research, 2003, Volume: 159, Issue:4

    Topics: Adenocarcinoma; Autocrine Communication; Cobalt Radioisotopes; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Prostatic Neoplasms; Protein Biosynthesis; Proteins; Quinazolines; Tumor Cells, Cultured; Tyrphostins; X-ray Repair Cross Complementing Protein 1

2003
Activated epidermal growth factor receptor (ErbB1) protects the heart against stress-induced injury in mice.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2003, Volume: 285, Issue:2

    Topics: Aggression; Animals; Behavior, Animal; Cold Temperature; Epidermal Growth Factor; ErbB Receptors; Heart; Male; Mice; Myocardium; Quinazolines; Restraint, Physical; Stress, Physiological; Tyrphostins

2003
Epidermal growth factor as a biologic switch in hair growth cycle.
    The Journal of biological chemistry, 2003, Jul-11, Volume: 278, Issue:28

    Topics: Animals; Cell Division; Dimerization; Epidermal Growth Factor; Hair; Hair Follicle; Heterozygote; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Phenotype; Phosphorylation; Precipitin Tests; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin Physiological Phenomena; Time Factors; Tyrphostins

2003
Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
    Molecular endocrinology (Baltimore, Md.), 2003, Volume: 17, Issue:8

    Topics: Animals; Cell Differentiation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dinoprost; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Lysophospholipids; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; Parathyroid Hormone; Phosphorylation; Protein Kinase C; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin; Signal Transduction; Transcriptional Activation; Tyrphostins

2003
Inhibitors that target protein kinases for the treatment of ovarian carcinoma.
    American journal of obstetrics and gynecology, 2003, Volume: 188, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Catechols; Cell Cycle; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Nitriles; Ovarian Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Time Factors; Tumor Cells, Cultured; Tyrphostins

2003
Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells.
    Investigative ophthalmology & visual science, 2003, Volume: 44, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Carbachol; Cells, Cultured; Cholinergic Agonists; Conjunctiva; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Goblet Cells; Humans; Male; Middle Aged; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Piperidines; Quinazolines; Rats; Rats, Sprague-Dawley; Time Factors; Tyrphostins

2003
Epidermal growth factor receptor-independent constitutive activation of STAT3 in head and neck squamous cell carcinoma is mediated by the autocrine/paracrine stimulation of the interleukin 6/gp130 cytokine system.
    Cancer research, 2003, Jun-01, Volume: 63, Issue:11

    Topics: Antigens, CD; Apoptosis; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cytokine Receptor gp130; DNA-Binding Proteins; Enzyme Inhibitors; ErbB Receptors; Head and Neck Neoplasms; Humans; Interleukin-6; Membrane Glycoproteins; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tumor Cells, Cultured; Tyrphostins

2003
Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR.
    American journal of physiology. Lung cellular and molecular physiology, 2003, Volume: 285, Issue:4

    Topics: Animals; Arachidonate 5-Lipoxygenase; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cell Division; Chemokines; Collagen; Cytokines; Enzyme Inhibitors; Eosinophils; ErbB Receptors; Leukotrienes; Lung; Male; Mice; Mice, Inbred Strains; Mucus; Muscle, Smooth; Ovalbumin; Protein-Tyrosine Kinases; Quinazolines; RNA, Messenger; Tyrphostins

2003
Activation of ERK1/2 by platelet-activating factor receptor is independent of receptor internalisation and G-protein activation.
    Cellular signalling, 2003, Volume: 15, Issue:9

    Topics: Animals; Arrestins; beta-Adrenergic Receptor Kinases; Blotting, Western; Cell Line; Chlorocebus aethiops; Clathrin-Coated Vesicles; Cloning, Molecular; COS Cells; Cyclic AMP-Dependent Protein Kinases; Dynamins; Endocytosis; ErbB Receptors; Humans; Isoproterenol; Leukotriene B4; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutagenesis, Site-Directed; Pertussis Toxin; Phosphorylation; Platelet Membrane Glycoproteins; Quinazolines; Receptors, G-Protein-Coupled; Signal Transduction; Sucrose; Transfection; Tyrphostins

2003
Alpha-adrenergic stimulation of ERK phosphorylation in astrocytes is alpha(2)-specific and may be mediated by transactivation.
    Brain research, 2003, Jul-18, Volume: 978, Issue:1-2

    Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Animals, Newborn; Astrocytes; Blotting, Western; Brain; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Fibrinolytic Agents; Heparin; Imidazoles; Mice; Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Quinazolines; Time Factors; Transcriptional Activation; Tyrphostins

2003
Inhibition of zebrafish epidermal growth factor receptor activity results in cardiovascular defects.
    Mechanisms of development, 2003, Volume: 120, Issue:7

    Topics: Amino Acid Sequence; Animals; Cardiovascular Abnormalities; ErbB Receptors; Humans; Molecular Sequence Data; Pyrimidines; Pyrroles; Quinazolines; Rats; Tyrphostins; Zebrafish

2003
Expression of ErbB receptors in ES cell-derived cardiomyocytes.
    Biochemical and biophysical research communications, 2003, Sep-12, Volume: 309, Issue:1

    Topics: Animals; Apoptosis; Cell Differentiation; Cell Division; Culture Media, Serum-Free; Embryo, Mammalian; Enzyme Inhibitors; ErbB Receptors; Green Fluorescent Proteins; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Luminescent Proteins; Mice; Mice, Transgenic; Microscopy, Fluorescence; Myocardium; Neuregulin-1; Quinazolines; Receptor, ErbB-4; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Stem Cells; Time Factors; Transcription Factors; Tyrphostins; Xenopus Proteins

2003
EGFRvIII-mediated radioresistance through a strong cytoprotective response.
    Oncogene, 2003, Aug-28, Volume: 22, Issue:36

    Topics: Animals; Apoptosis; CHO Cells; Cricetinae; Cytoprotection; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Radiation Tolerance; Tyrphostins

2003
EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2.
    Oncogene, 2003, Sep-04, Volume: 22, Issue:38

    Topics: Actins; Animals; Cell Adhesion; Cells, Cultured; COS Cells; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Guanosine Triphosphate; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Oncogene Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-vav; Quinazolines; rac GTP-Binding Proteins; Tyrosine; Tyrphostins

2003
Epidermal growth factor receptor regulates normal urothelial regeneration.
    Laboratory investigation; a journal of technical methods and pathology, 2003, Volume: 83, Issue:9

    Topics: Amphiregulin; Antibodies, Blocking; Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Movement; Cells, Cultured; DNA Primers; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Quinazolines; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transforming Growth Factor alpha; Tyrphostins; Urothelium; Wound Healing

2003
Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.
    Experimental cell research, 2003, Oct-01, Volume: 289, Issue:2

    Topics: 3T3 Cells; Animals; Cell Communication; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Hepatocyte Growth Factor; Humans; Kidney; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins; Quinazolines; Receptor Cross-Talk; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrphostins

2003
Human airway trypsin-like protease increases mucin gene expression in airway epithelial cells.
    American journal of respiratory cell and molecular biology, 2004, Volume: 30, Issue:4

    Topics: Amphiregulin; Aprotinin; Dose-Response Relationship, Drug; EGF Family of Proteins; Epithelial Cells; ErbB Receptors; Gene Expression Regulation; Glycoconjugates; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Leupeptins; Mucin 5AC; Mucin-2; Mucins; Protease Inhibitors; Quinazolines; Receptor, PAR-2; Respiratory Mucosa; Respiratory System; Serine Endopeptidases; Signal Transduction; Time Factors; Tumor Cells, Cultured; Tyrphostins

2004
Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway.
    The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52

    Topics: Animals; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Cycle Proteins; Cell Division; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Male; MAP Kinase Signaling System; Microscopy, Confocal; Muscle, Smooth, Vascular; Phenotype; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; S Phase; Time Factors; Tumor Suppressor Proteins; Tyrphostins

2003
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.
    The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52

    Topics: Androstadienes; Animals; Blotting, Western; Catalysis; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Kinetics; Male; Mice; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Potassium; Precipitin Tests; Protein Precursors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Time Factors; Transcriptional Activation; Tyrphostins; Up-Regulation; Venoms; Wortmannin

2003
Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.
    Cellular signalling, 2003, Volume: 15, Issue:12

    Topics: Androstadienes; Animals; Carbachol; cdc42 GTP-Binding Protein; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Kinetics; Lysophospholipids; Maleimides; Mice; Models, Biological; Myelin Basic Protein; NIH 3T3 Cells; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Quinazolines; rac GTP-Binding Proteins; ras Proteins; Receptor, Muscarinic M2; Receptors, Cell Surface; rho GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrphostins; Wortmannin

2003
Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells.
    Cancer research, 2003, Oct-15, Volume: 63, Issue:20

    Topics: Acetylcholine; Animals; Atropine; Cell Division; CHO Cells; Cholinergic Agonists; Colonic Neoplasms; Cricetinae; Drug Interactions; Egtazic Acid; ErbB Receptors; Flavonoids; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Ribosomal Protein S6 Kinases, 90-kDa; Transcriptional Activation; Tyrphostins

2003
Gs protein-coupled receptor agonists induce transactivation of the epidermal growth factor receptor in T84 cells: implications for epithelial secretory responses.
    The Journal of biological chemistry, 2004, Feb-20, Volume: 279, Issue:8

    Topics: Androstadienes; Blotting, Western; Cell Line; Chlorides; Chlorine; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Flavonoids; GTP-Binding Protein alpha Subunits, Gs; Humans; Ions; Isoquinolines; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Phosphorylation; Precipitin Tests; Protein Binding; Quinazolines; Sulfonamides; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Vasoactive Intestinal Peptide; Wortmannin

2004
Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Dec-23, Volume: 100, Issue:26

    Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Survival; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Glioma; Head and Neck Neoplasms; Humans; Mice; Mice, Nude; Quinazolines; Transplantation, Heterologous; Tumor Cells, Cultured; Tyrphostins

2003
Expression of a naturally occurring constitutively active variant of the epidermal growth factor receptor in mouse fibroblasts increases motility.
    International journal of cancer, 2004, Feb-20, Volume: 108, Issue:5

    Topics: 3T3 Cells; Animals; Cell Adhesion; Cell Movement; Enzyme Inhibitors; ErbB Receptors; Fibroblasts; Glioblastoma; Mice; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Phospholipase C gamma; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor Protein-Tyrosine Kinases; Tumor Cells, Cultured; Type C Phospholipases; Tyrphostins

2004
Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells.
    The Journal of investigative dermatology, 2003, Volume: 121, Issue:5

    Topics: Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Quinazolines; Repressor Proteins; RNA, Messenger; Skin Neoplasms; Telomerase; Transforming Growth Factor alpha; Tyrphostins

2003
EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases.
    Experimental cell research, 2004, Jan-01, Volume: 292, Issue:1

    Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Female; Genes, src; Humans; Kinetics; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Peptide Fragments; Phosphorylation; Quinazolines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Transcriptional Activation; Tyrphostins; Urokinase-Type Plasminogen Activator

2004
Inhibition of epidermal growth factor receptor signaling protects human malignant glioma cells from hypoxia-induced cell death.
    Cancer research, 2004, Mar-01, Volume: 64, Issue:5

    Topics: Adenosine Triphosphate; Cell Death; Cell Hypoxia; DNA Replication; ErbB Receptors; Glioma; Glucose; Humans; Membrane Potentials; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Signal Transduction; Tyrphostins

2004
Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation.
    The Journal of biological chemistry, 2004, May-14, Volume: 279, Issue:20

    Topics: Cell Division; Cell Line, Tumor; Colonic Neoplasms; ErbB Receptors; Humans; Kinetics; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, PAR-2; Transcriptional Activation; Trypsin; Tyrphostins

2004
gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension.
    Circulation, 2004, Apr-13, Volume: 109, Issue:14

    Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetylcholine; Angiotensin II; Animals; Antioxidants; Aorta; Bacterial Toxins; Cardiomyopathy, Hypertrophic; Cytochromes b; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Glycoproteins; Hypertension, Renovascular; Indoles; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Nitric Oxide; Organ Culture Techniques; Polyethylene Glycols; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Superoxide Dismutase; Superoxides; Tyrphostins; Vasodilation; Vasodilator Agents

2004
Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells.
    Circulation research, 2004, Apr-30, Volume: 94, Issue:8

    Topics: Animals; Aorta; CHO Cells; Cricetinae; Cricetulus; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gi-Go; Lysophospholipids; MAP Kinase Signaling System; Membrane Lipids; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Sphingosine; Superoxides; Transcriptional Activation; Tyrphostins

2004
Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.
    Molecular cancer therapeutics, 2004, Volume: 3, Issue:4

    Topics: Antibodies, Monoclonal; Cell Division; Cell Line, Tumor; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Inhibitory Concentration 50; Phosphorylation; Quinazolines; Receptor, ErbB-2; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrphostins

2004
Insulin reduces the requirement for EGFR transactivation in bombesin-induced DNA synthesis.
    Biochemical and biophysical research communications, 2004, Jun-11, Volume: 318, Issue:4

    Topics: Animals; Bombesin; DNA; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Insulin; Mice; Protein Tyrosine Phosphatases; Quinazolines; Swiss 3T3 Cells; Thymidine; Transcriptional Activation; Tritium; Tyrphostins

2004
Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells.
    American journal of physiology. Renal physiology, 2004, Volume: 287, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Caspases; Cell Line, Transformed; Cisplatin; Enzyme Inhibitors; ErbB Receptors; Kidney Tubules, Proximal; Male; MAP Kinase Signaling System; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Quinazolines; src-Family Kinases; Tyrphostins

2004
Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity.
    British journal of pharmacology, 2004, Volume: 142, Issue:4

    Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gi-Go; Hong Kong; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-jun; Quinazolines; Receptors, G-Protein-Coupled; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; src-Family Kinases; Type C Phospholipases; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2

2004
The AG1478 tyrosine kinase inhibitor is an effective suppressor of leiomyoma cell growth.
    Human reproduction (Oxford, England), 2004, Volume: 19, Issue:9

    Topics: Adult; Apoptosis; Cell Cycle; Cell Division; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Estradiol; Female; Humans; Leiomyoma; Myometrium; Phosphorylation; Progesterone; Protein-Tyrosine Kinases; Quinazolines; Tyrphostins; Uterine Neoplasms

2004
The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells.
    Thrombosis and haemostasis, 2004, Volume: 92, Issue:1

    Topics: Binding Sites; Cell Line; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; ErbB Receptors; Factor VIIa; Focal Adhesion Kinase 2; Heparin-binding EGF-like Growth Factor; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Interleukin-8; Keratinocytes; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Recombinant Proteins; RNA, Messenger; Signal Transduction; Thromboplastin; Transcription Factors; Tyrphostins

2004
[Effect of EGF on the intracellular distribution of heat-shock proteins in A431 cells].
    Tsitologiia, 2003, Volume: 45, Issue:8

    Topics: Antibodies, Monoclonal; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Estrenes; Fluorescent Antibody Technique; Heat-Shock Proteins; Hot Temperature; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Phosphorylation; Protein-Tyrosine Kinases; Pyrrolidinones; Quinazolines; Time Factors; Type C Phospholipases; Tyrphostins; Vanadates

2003
Activation of epidermal growth factor receptor via CCR3 in bronchial epithelial cells.
    Biochemical and biophysical research communications, 2004, Jul-23, Volume: 320, Issue:2

    Topics: Bronchi; Cell Line; Chemokine CCL11; Chemokines, CC; Epithelial Cells; ErbB Receptors; Humans; Interleukin-8; Phosphorylation; Quinazolines; Receptor Cross-Talk; Receptors, CCR3; Receptors, Chemokine; Signal Transduction; Tyrosine; Tyrphostins

2004
Extracellular calcium-sensing receptor transactivates the epidermal growth factor receptor by a triple-membrane-spanning signaling mechanism.
    Biochemical and biophysical research communications, 2004, Jul-23, Volume: 320, Issue:2

    Topics: Cell Line; Enzyme Inhibitors; ErbB Receptors; Humans; Phosphorylation; Quinazolines; Receptors, Calcium-Sensing; Signal Transduction; Transcriptional Activation; Tyrosine; Tyrphostins

2004
Mechanisms of vascular angiotensin II surface receptor regulation by epidermal growth factor.
    Journal of cellular physiology, 2004, Volume: 200, Issue:3

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Cells, Cultured; Cytochalasin D; Dactinomycin; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Ligands; Muscle, Smooth, Vascular; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tyrphostins

2004
Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells.
    Endocrinology, 2004, Volume: 145, Issue:11

    Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Heparin-binding EGF-like Growth Factor; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Mouth Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Receptor Cross-Talk; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrphostins

2004
Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.
    Molecular endocrinology (Baltimore, Md.), 2004, Volume: 18, Issue:11

    Topics: Animals; Cell Line; Chlorocebus aethiops; Endocytosis; ErbB Receptors; Humans; Insulin-Like Growth Factor I; Metalloendopeptidases; Mice; Mitogen-Activated Protein Kinase 3; Paracrine Communication; Phenylalanine; Phosphorylation; Quinazolines; Rats; Receptors, Somatomedin; Tetradecanoylphorbol Acetate; Thiophenes; Tyrosine; Tyrphostins

2004
INK4a/Arf is required for suppression of EGFR/DeltaEGFR(2-7)-dependent ERK activation in mouse astrocytes and glioma.
    Oncogene, 2004, Sep-09, Volume: 23, Issue:41

    Topics: Animals; Astrocytes; Cyclin-Dependent Kinase Inhibitor p16; Enzyme Activation; ErbB Receptors; Glioma; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Tyrphostins

2004
Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae.
    Oncogene, 2004, Sep-09, Volume: 23, Issue:41

    Topics: Caveolin 1; Caveolins; Cell Division; Cell Line, Tumor; ErbB Receptors; Glioblastoma; Humans; Phosphorylation; Quinazolines; Tyrosine; Tyrphostins

2004
Metalloprotease disintegrin-mediated ectodomain shedding of EGFR ligands promotes intestinal epithelial restitution.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:6

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Autocrine Communication; Blotting, Western; Cell Line; Culture Media, Conditioned; Epithelium; ErbB Receptors; Immunoprecipitation; Indicators and Reagents; Intestinal Mucosa; Ligands; Metalloendopeptidases; Metalloproteases; Neutralization Tests; Paracrine Communication; Protease Inhibitors; Quinazolines; Rats; Transforming Growth Factor alpha; Tyrphostins

2004
Activation of epidermal growth factor receptors directs astrocytes to organize in a network surrounding axons in the developing rat optic nerve.
    Developmental biology, 2004, Sep-15, Volume: 273, Issue:2

    Topics: Animals; Animals, Newborn; Astrocytes; Axons; Culture Techniques; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Optic Nerve; Quinazolines; Rats; Rats, Wistar; Tyrphostins

2004
L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer.
    American journal of physiology. Gastrointestinal and liver physiology, 2004, Volume: 287, Issue:3

    Topics: Acetaldehyde; Actins; Adherens Junctions; Caco-2 Cells; Cell Membrane Permeability; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Egtazic Acid; Endotoxins; ErbB Receptors; Glutamine; Humans; Lipopolysaccharides; Mannitol; Membrane Proteins; Occludin; Phosphorylation; Quinazolines; Tight Junctions; Tyrosine; Tyrphostins

2004
Biglycan is internalized via a chlorpromazine-sensitive route.
    Cellular & molecular biology letters, 2004, Volume: 9, Issue:3

    Topics: Biglycan; Caveolae; Cells, Cultured; Chlorpromazine; Clathrin-Coated Vesicles; Decorin; Endocytosis; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix Proteins; Fibroblasts; Filipin; Humans; Phosphorylation; Proteoglycans; Quinazolines; Skin; Tyrphostins

2004
Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.
    Molecular and cellular endocrinology, 2004, Sep-30, Volume: 224, Issue:1-2

    Topics: Androgens; Animals; Autocrine Communication; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gene Expression Regulation; Isoquinolines; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinases; Phosphoproteins; Quinazolines; Rats; RNA, Messenger; Steroids; Sulfonamides; Transforming Growth Factor alpha; Tyrphostins

2004
Simultaneously targeting epidermal growth factor receptor tyrosine kinase and cyclooxygenase-2, an efficient approach to inhibition of squamous cell carcinoma of the head and neck.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2004, Sep-01, Volume: 10, Issue:17

    Topics: Angiogenesis Inhibitors; Apoptosis; Carcinoma, Squamous Cell; Celecoxib; Cell Cycle; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Synergism; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Gefitinib; Head and Neck Neoplasms; Humans; Immunoblotting; Immunoprecipitation; In Situ Nick-End Labeling; Isoenzymes; Laryngeal Neoplasms; Lymphatic Metastasis; Membrane Proteins; Neovascularization, Pathologic; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Quinazolines; Sulfonamides; Tumor Cells, Cultured; Tumor Stem Cell Assay; Tyrphostins

2004
Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells.
    Oncogene, 2004, Oct-14, Volume: 23, Issue:47

    Topics: 3T3 Cells; Animals; Apoptosis; Binding Sites; Cell Line; Cell Transformation, Neoplastic; Cytokines; DNA Replication; Enzyme Inhibitors; ErbB Receptors; Genes, erbB-1; Hematopoietic Stem Cells; Humans; MAP Kinase Signaling System; Mice; Quinazolines; Receptor, ErbB-2; Tyrphostins

2004
Clustering of cellular prion protein induces ERK1/2 and stathmin phosphorylation in GT1-7 neuronal cells.
    FEBS letters, 2004, Oct-08, Volume: 576, Issue:1-2

    Topics: Animals; Antibodies, Monoclonal; Blotting, Western; Butadienes; Cells, Cultured; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Mice; Microscopy, Confocal; Microtubule Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Nitriles; Phosphoproteins; Phosphorylation; PrPC Proteins; Quinazolines; RNA, Small Interfering; Stathmin; Tyrphostins

2004
Transactivation of epidermal growth factor receptor mediates catecholamine-induced growth of vascular smooth muscle.
    Circulation research, 2004, Nov-12, Volume: 95, Issue:10

    Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Anthracenes; Aorta, Thoracic; Bacterial Proteins; Benzopyrans; Butadienes; Catheterization; Cell Division; Dipeptides; ErbB Receptors; Flavonoids; Glycine; Hydroxamic Acids; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nitriles; Organ Culture Techniques; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Pyridines; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Thrombin; Tyrphostins

2004
Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.
    Annals of clinical and laboratory science, 2004,Summer, Volume: 34, Issue:3

    Topics: Angiotensin II; Animals; Butadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Immunoblotting; Losartan; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tyrphostins

2004
Entry of herpes simplex virus mediated by chimeric forms of nectin1 retargeted to endosomes or to lipid rafts occurs through acidic endosomes.
    Journal of virology, 2004, Volume: 78, Issue:22

    Topics: Ammonium Chloride; Androstadienes; Animals; Cell Adhesion Molecules; Cricetinae; Endocytosis; Endosomes; ErbB Receptors; Macrolides; Membrane Fusion; Membrane Microdomains; Nectins; Quinazolines; Receptors, Virus; Simplexvirus; Tyrphostins; Wortmannin

2004
Enhanced epidermal growth factor receptor activation in human cholangiocarcinoma cells.
    Journal of hepatology, 2004, Volume: 41, Issue:5

    Topics: Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cholangiocarcinoma; Cyclooxygenase 2; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Humans; Membrane Proteins; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Quinazolines; Signal Transduction; Tyrphostins; Ubiquitin

2004
Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor.
    The Journal of biological chemistry, 2005, Jan-28, Volume: 280, Issue:4

    Topics: Androstadienes; Apoptosis; Caspase 3; Caspase 8; Caspases; Cell Line; Cell Membrane; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Cells; Epidermis; Epithelial Cells; ErbB Receptors; Genes, Dominant; Humans; Immunoblotting; Microscopy, Confocal; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, Angiotensin, Type 1; Signal Transduction; Threonine; Time Factors; Tyrphostins; Wortmannin

2005
Epidermal growth factor receptor-dependent and -independent pathways in hydrogen peroxide-induced mitogen-activated protein kinase activation in cardiomyocytes and heart fibroblasts.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 312, Issue:3

    Topics: Animals; ErbB Receptors; Fibroblasts; Hydrogen Peroxide; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Quinazolines; Rats; Receptor, Insulin; Signal Transduction; src-Family Kinases; Tyrphostins

2005
Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent.
    Journal of cellular physiology, 2005, Volume: 204, Issue:1

    Topics: Animals; Aorta; Cell Movement; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Gene Expression; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins pp60(c-src); Pyrazoles; Pyrimidines; Quinazolines; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins

2005
Novel use of zebrafish as a vertebrate model to screen radiation protectors and sensitizers.
    International journal of radiation oncology, biology, physics, 2005, Jan-01, Volume: 61, Issue:1

    Topics: Amifostine; Animals; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Models, Animal; Quinazolines; Radiation Injuries, Experimental; Radiation-Protective Agents; Radiation-Sensitizing Agents; Survival Analysis; Tyrphostins; Zebrafish

2005
Growth of intestinal epithelium in organ culture is dependent on EGF signalling.
    Experimental cell research, 2005, Feb-15, Volume: 303, Issue:2

    Topics: Animals; Apoptosis; Body Patterning; Cell Proliferation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Female; Intestines; Mice; Mice, Inbred ICR; Organ Culture Techniques; Pregnancy; Quinazolines; Signal Transduction; Tyrphostins

2005
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.
    The Journal of cell biology, 2005, Jan-31, Volume: 168, Issue:3

    Topics: Actin Depolymerizing Factors; Actin-Related Protein 2; Actin-Related Protein 3; Actins; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Cytoskeletal Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Fibronectins; GRB2 Adaptor Protein; Microfilament Proteins; Microscopy, Fluorescence; Models, Biological; Neoplasm Invasiveness; Nerve Tissue Proteins; Oncogene Proteins; Quinazolines; Rats; RNA, Small Interfering; Transfection; Tyrphostins; Wiskott-Aldrich Syndrome Protein Family; Wiskott-Aldrich Syndrome Protein, Neuronal

2005
The effects of S-phase kinase-associated protein 2 (SKP2) on cell cycle status, viability, and chemoresistance in A549 lung adenocarcinoma cells.
    Experimental lung research, 2004, Volume: 30, Issue:8

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Cisplatin; Cyclin E; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Quinazolines; S-Phase Kinase-Associated Proteins; Tyrphostins

2004
Activated EGFR promotes the survival of B-lineage acute leukemia in the absence of stromal cells.
    Cell cycle (Georgetown, Tex.), 2005, Volume: 4, Issue:3

    Topics: Annexin A5; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Bone Marrow; Bone Marrow Cells; Burkitt Lymphoma; Cell Cycle; Cell Line, Tumor; Cell Separation; Cell Survival; Cells, Cultured; Coculture Techniques; ErbB Receptors; Flow Cytometry; Humans; MAP Kinase Kinase Kinases; Phosphatidylinositol 3-Kinases; Quinazolines; Retroviridae; Stromal Cells; Time Factors; Tumor Cells, Cultured; Tyrphostins

2005
[Effect of tyrosine kinase inhibitors on airway remodeling in bronchial asthma].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2005, Volume: 36, Issue:1

    Topics: Animals; Asthma; Cells, Cultured; ErbB Receptors; Genistein; Male; Protein-Tyrosine Kinases; Quinazolines; Random Allocation; Rats; Rats, Sprague-Dawley; Trachea; Tyrphostins

2005
Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner.
    American journal of respiratory cell and molecular biology, 2005, Volume: 32, Issue:5

    Topics: Amphiregulin; Autocrine Communication; Bronchi; Cells, Cultured; Compressive Strength; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gene Expression Regulation; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Quinazolines; Respiratory Mucosa; Signal Transduction; Stress, Mechanical; Time Factors; Tyrphostins

2005
Amphiregulin acts as an autocrine survival factor for adult sensory neurons.
    Neuroreport, 2005, Feb-28, Volume: 16, Issue:3

    Topics: Amphiregulin; Animals; Axons; Cell Survival; Cells, Cultured; Culture Techniques; Dose-Response Relationship, Drug; Drug Interactions; EGF Family of Proteins; Enzyme Inhibitors; ErbB Receptors; Female; Ganglia, Spinal; Glycoproteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Mice; Neurons, Afferent; Quinazolines; Tyrphostins

2005
Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.
    Cancer research, 2005, Feb-15, Volume: 65, Issue:4

    Topics: Alkaloids; Benzophenanthridines; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Morpholines; Phenanthridines; Protein Kinase C; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2005
The role of tyrosine kinase-mediated pathways in diabetes-induced alterations in responsiveness of rat carotid artery.
    Autonomic & autacoid pharmacology, 2005, Volume: 25, Issue:2

    Topics: Animals; Benzothiazoles; Body Weight; Carotid Arteries; Diabetes Mellitus, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Genes, erbB-1; Genes, erbB-2; Genistein; In Vitro Techniques; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tyrphostins; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2005
Endothelin-1 stimulates cyclooxygenase-2 expression in ovarian cancer cells through multiple signaling pathways: evidence for involvement of transactivation of the epidermal growth factor receptor.
    Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Endothelin A Receptor Antagonists; Endothelin-1; Enzyme Induction; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovarian Neoplasms; p38 Mitogen-Activated Protein Kinases; Peptides, Cyclic; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptor, Endothelin A; Signal Transduction; Transcriptional Activation; Tyrphostins

2004
EGF receptor transactivation in angiotensin II and endothelin control of vascular protein synthesis in vivo.
    Journal of cardiovascular pharmacology, 2004, Volume: 44 Suppl 1

    Topics: Angiotensin II; Animals; Blood Pressure; Disease Models, Animal; Endothelins; ErbB Receptors; Heart Rate; Hypertension; Infusion Pumps, Implantable; Mesenteric Arteries; Protein Biosynthesis; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrphostins

2004
Epidermal growth factor receptor tyrosine kinase-mediated signalling contributes to diabetes-induced vascular dysfunction in the mesenteric bed.
    British journal of pharmacology, 2005, Volume: 145, Issue:6

    Topics: Angiotensin II; Animals; Carbachol; Cell Line; Diabetes Mellitus, Experimental; Endothelin-1; ErbB Receptors; Female; Genistein; Histamine; Humans; In Vitro Techniques; Mesenteric Arteries; Mesenteric Veins; Norepinephrine; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Streptozocin; Tyrphostins; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents

2005
Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases.
    Journal of neurochemistry, 2005, Volume: 93, Issue:4

    Topics: Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Genetic Vectors; Humans; Indole Alkaloids; Microscopy, Confocal; Neuroblastoma; Piperazines; Platelet-Derived Growth Factor; Quinazolines; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Dopamine D2; Simplexvirus; Spiperone; Transcriptional Activation; Transfection; Tritium; Tyrphostins

2005
EGF-induced EGF-receptor and MAP kinase phosphorylation in goat cumulus cells during in vitro maturation.
    Molecular reproduction and development, 2005, Volume: 71, Issue:4

    Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Goats; Immunoassay; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Ovarian Follicle; Phosphorylation; Quinazolines; Time Factors; Tyrphostins

2005
Dominant-negative Notch3 receptor inhibits mitogen-activated protein kinase pathway and the growth of human lung cancers.
    Cancer research, 2005, May-01, Volume: 65, Issue:9

    Topics: Apoptosis; Cell Cycle Proteins; Cell Growth Processes; Cell Line, Tumor; Down-Regulation; Dual Specificity Phosphatase 1; Enzyme Inhibitors; ErbB Receptors; Humans; Immediate-Early Proteins; Lung Neoplasms; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Quinazolines; Receptor, Notch3; Receptors, Cell Surface; Receptors, Notch; Transfection; Tyrphostins

2005
Chemoprevention of UV light-induced skin tumorigenesis by inhibition of the epidermal growth factor receptor.
    Cancer research, 2005, May-01, Volume: 65, Issue:9

    Topics: Animals; Anticarcinogenic Agents; Cell Proliferation; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Hyperplasia; MAP Kinase Signaling System; Mice; Mice, Nude; Neoplasms, Radiation-Induced; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Skin; Skin Neoplasms; Tyrphostins; Ultraviolet Rays

2005
Differential sensitivities of trastuzumab (Herceptin)-resistant human breast cancer cells to phosphoinositide-3 kinase (PI-3K) and epidermal growth factor receptor (EGFR) kinase inhibitors.
    Breast cancer research and treatment, 2005, Volume: 91, Issue:2

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromones; Drug Resistance, Neoplasm; ErbB Receptors; Female; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Trastuzumab; Tumor Cells, Cultured; Tyrphostins

2005
Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology.
    Oral oncology, 2005, Volume: 41, Issue:5

    Topics: Blotting, Western; Carcinoma, Squamous Cell; Cell Communication; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Head and Neck Neoplasms; Humans; Neoplasm Proteins; Quinazolines; Signal Transduction; Tyrphostins

2005
Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG 1478-mesylate, with albumin.
    Analytical biochemistry, 2005, Jul-15, Volume: 342, Issue:2

    Topics: Protein Binding; Quinazolines; Serum Albumin; Spectrometry, Fluorescence; Tyrphostins; Ultracentrifugation

2005
Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:6

    Topics: Animals; Astrocytes; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Nitrobenzenes; Optic Nerve; Optic Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Wistar; Sulfonamides; Tyrphostins

2005
Studies of tyrosine phosphorylation and Src family tyrosine kinases in the lens epithelium.
    Investigative ophthalmology & visual science, 2005, Volume: 46, Issue:6

    Topics: Animals; Blotting, Western; Cell Proliferation; Enzyme Inhibitors; Epithelium; Lens, Crystalline; Organ Culture Techniques; Phosphorylation; Phosphotyrosine; Proliferating Cell Nuclear Antigen; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; src-Family Kinases; Swine; Tyrosine; Tyrphostins

2005
Role of EGF receptor transactivation in phosphoinositide 3-kinase-dependent activation of MAP kinase by GPCRs.
    Journal of cellular physiology, 2006, Volume: 206, Issue:1

    Topics: Androstadienes; Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 2; Gonadotropin-Releasing Hormone; Hepatocytes; Humans; Kidney; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphatidylinositol 3-Kinases; Protein Kinase C; Quinazolines; ras Proteins; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Tyrphostins; Wortmannin

2006
A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes.
    Experimental cell research, 2005, Jul-01, Volume: 307, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Chlorocebus aethiops; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescence Recovery After Photobleaching; Fluorescence Resonance Energy Transfer; HeLa Cells; Humans; Immunoblotting; Kinetics; Microscopy, Video; Molecular Probes; Phosphorylation; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Quinazolines; Tyrosine; Tyrphostins

2005
Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.
    American journal of respiratory cell and molecular biology, 2005, Volume: 33, Issue:4

    Topics: Animals; Arginase; Cattle; Cells, Cultured; Cytokines; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; ErbB Receptors; Genistein; Growth Inhibitors; Humans; Isoenzymes; Lipopolysaccharides; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pulmonary Artery; Quinazolines; Tumor Necrosis Factor-alpha; Tyrphostins; Urea

2005
Synergy of epidermal growth factor receptor kinase inhibitor AG1478 and ErbB2 kinase inhibitor AG879 in human colon carcinoma cells is associated with induction of apoptosis.
    Cancer research, 2005, Jul-01, Volume: 65, Issue:13

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Humans; Phosphorylation; Quinazolines; Receptor, ErbB-2; Tyrphostins

2005
PGE2 up-regulates vascular endothelial growth factor expression in MKN28 gastric cancer cells via epidermal growth factor receptor signaling system.
    Experimental oncology, 2005, Volume: 27, Issue:2

    Topics: Calcium-Calmodulin-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Oxytocics; Phosphorylation; Quinazolines; RNA, Messenger; Signal Transduction; Stomach Neoplasms; Transcriptional Activation; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Vascular Endothelial Growth Factor A

2005
Inhibitors of tyrosine kinase inhibit the production of urokinase plasminogen activator in human prostatic cancer cells.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2005, Volume: 113, Issue:5

    Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Genistein; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Urokinase-Type Plasminogen Activator

2005
Signal transduction through substance P receptor in human glioblastoma cells: roles for Src and PKCdelta.
    Cancer chemotherapy and pharmacology, 2005, Volume: 56, Issue:6

    Topics: Acetophenones; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Intracellular Signaling Peptides and Proteins; Oligonucleotides, Antisense; Phosphorylation; Protein Kinase C-delta; Pyrimidines; Quinazolines; Receptors, Neurokinin-1; RNA, Small Interfering; Signal Transduction; Tyrphostins

2005
beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
    The Journal of biological chemistry, 2005, Sep-16, Volume: 280, Issue:37

    Topics: Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epitopes; ErbB Receptors; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Lysophospholipids; Mice; Mice, Knockout; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphorylation; Quinazolines; ras Proteins; RNA; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrphostins

2005
Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension.
    Circulation, 2005, Jul-19, Volume: 112, Issue:3

    Topics: Animals; Apoptosis; Enzyme Inhibitors; ErbB Receptors; Hypertension, Pulmonary; Integrin alphaVbeta3; Male; Metalloproteases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Organ Culture Techniques; Protease Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins

2005
Correlation of translocation of tight junction protein Zonula occludens-1 and activation of epidermal growth factor receptor in the regulation of invasion of pancreatic cancer cells.
    International journal of oncology, 2005, Volume: 27, Issue:3

    Topics: Animals; BALB 3T3 Cells; Cell Line, Tumor; Cell Movement; Culture Media, Conditioned; Enzyme Inhibitors; ErbB Receptors; Humans; Membrane Proteins; Mice; Neoplasm Invasiveness; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; Tight Junctions; Tyrphostins; Zonula Occludens-1 Protein

2005
Air pollution particles activate NF-kappaB on contact with airway epithelial cell surfaces.
    Toxicology and applied pharmacology, 2005, Oct-01, Volume: 208, Issue:1

    Topics: Air Pollutants; Animals; Binding, Competitive; Biological Transport; Deferoxamine; Dust; Epithelial Cells; Ferric Compounds; Free Radical Scavengers; In Vitro Techniques; NF-kappa B; Particle Size; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiourea; Time Factors; Titanium; Trachea; Tyrphostins

2005
PTPase inhibition restores ERK1/2 phosphorylation and protects mammary epithelial cells from apoptosis.
    Biochemical and biophysical research communications, 2005, Nov-04, Volume: 336, Issue:4

    Topics: Animals; Apoptosis; Cell Adhesion; Cell Survival; Cells, Cultured; Epithelial Cells; ErbB Receptors; Female; Flavonoids; Insulin; Laminin; Mammary Glands, Animal; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Tyrphostins; Vanadates

2005
Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer.
    BMC cancer, 2005, Oct-03, Volume: 5

    Topics: Antibodies, Monoclonal; beta-Lactamases; Butadienes; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunohistochemistry; Inhibitory Concentration 50; MAP Kinase Kinase 1; Neoplasms; Nitriles; Oligonucleotides, Antisense; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transfection; Tyrphostins

2005
Enhanced efficacy of radioimmunotherapy with 90Y-CHX-A''-DTPA-hu3S193 by inhibition of epidermal growth factor receptor (EGFR) signaling with EGFR tyrosine kinase inhibitor AG1478.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Oct-01, Volume: 11, Issue:19 Pt 2

    Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Lewis Blood Group Antigens; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Pentetic Acid; Protein-Tyrosine Kinases; Quinazolines; Radioimmunotherapy; Radiopharmaceuticals; Signal Transduction; Time Factors; Tissue Distribution; Tyrphostins; Yttrium Radioisotopes

2005
EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans.
    Science (New York, N.Y.), 2005, Oct-07, Volume: 310, Issue:5745

    Topics: Animals; Axons; Calcium; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Enzyme Inhibitors; ErbB Receptors; Erlotinib Hydrochloride; GPI-Linked Proteins; Humans; Mice; Myelin Proteins; Nerve Crush; Nerve Regeneration; Neurites; Nogo Proteins; Nogo Receptor 1; Optic Nerve; Optic Nerve Injuries; Phosphorylation; Quinazolines; Receptors, Cell Surface; Retinal Ganglion Cells; Signal Transduction; Tyrphostins

2005
Tyrphostin-A47 inhibitable tyrosine phosphorylation of flagellar proteins is associated with distinct alteration of motility pattern in hamster spermatozoa.
    Molecular reproduction and development, 2006, Volume: 73, Issue:2

    Topics: Animals; Cells, Cultured; Computer Simulation; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flagella; Male; Phosphorylation; Quinazolines; Sperm Motility; Spermatozoa; Time Factors; Tyrosine; Tyrphostins

2006
Transactivation of epidermal growth factor receptor is involved in leptin-induced activation of janus-activated kinase 2 and extracellular signal-regulated kinase 1/2 in human gastric cancer cells.
    Cancer research, 2005, Oct-15, Volume: 65, Issue:20

    Topics: Cell Line, Tumor; Dipeptides; ErbB Receptors; Humans; Janus Kinase 2; Leptin; MAP Kinase Signaling System; Metalloproteases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protease Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinazolines; Receptors, Cell Surface; Receptors, Leptin; Recombinant Proteins; Stomach Neoplasms; Transcriptional Activation; Tyrphostins

2005
Helicobacter pylori-stimulated interleukin-8 (IL-8) promotes cell proliferation through transactivation of epidermal growth factor receptor (EGFR) by disintegrin and metalloproteinase (ADAM) activation.
    Digestive diseases and sciences, 2005, Volume: 50, Issue:11

    Topics: ADAM Proteins; Cell Line, Tumor; Cell Proliferation; DNA; Enzyme Activation; ErbB Receptors; Flavonoids; Glycine; Helicobacter pylori; Humans; Hydroxamic Acids; Interleukin-8; MAP Kinase Kinase 1; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Transcriptional Activation; Tyrphostins

2005
Lysophosphatidic acid-induced effects in human colon carcinoma DLD1 cells are partially dependent on transactivation of epidermal growth factor receptor.
    The Journal of surgical research, 2006, Volume: 132, Issue:1

    Topics: Cell Line, Tumor; Chemotaxis; Colonic Neoplasms; Dipeptides; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Humans; Interleukin-8; Lysophospholipids; Phosphorylation; Phosphotyrosine; Protease Inhibitors; Quinazolines; Transcriptional Activation; Tyrphostins

2006
Involvement of MMP-7 in invasion of pancreatic cancer cells through activation of the EGFR mediated MEK-ERK signal transduction pathway.
    Journal of clinical pathology, 2005, Volume: 58, Issue:12

    Topics: Adenocarcinoma; Adult; Aged; Blotting, Western; Butadienes; Culture Media, Conditioned; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Male; Matrix Metalloproteinase 7; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Nitriles; Pancreatic Neoplasms; Quinazolines; Signal Transduction; Tight Junctions; Tumor Cells, Cultured; Tyrphostins

2005
EGFR-dependent ERK activation triggers hydrogen peroxide-induced apoptosis in OK renal epithelial cells.
    Archives of toxicology, 2006, Volume: 80, Issue:6

    Topics: Animals; Apoptosis; Butadienes; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hydrogen Peroxide; Kidney Tubules, Proximal; MAP Kinase Kinase 1; Membrane Potentials; Mitochondrial Membranes; Nitriles; Opossums; Oxidants; Pyrimidines; Quinazolines; Transfection; Tyrphostins

2006
Direct involvement of G protein alpha(q/11) subunit in regulation of muscarinic receptor-mediated sAPPalpha release.
    Archives of pharmacal research, 2005, Volume: 28, Issue:11

    Topics: Amino Acid Sequence; Cell Line, Tumor; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Molecular Sequence Data; Muscarinic Agonists; Quinazolines; Receptor Cross-Talk; Receptor, Muscarinic M3; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Serum Amyloid A Protein; Transfection; Tyrphostins

2005
Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility.
    Experimental cell research, 2006, Feb-15, Volume: 312, Issue:4

    Topics: Actin Depolymerizing Factors; Actomyosin; Adenomatous Polyposis Coli Protein; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; beta Catenin; Cadherins; Calcium; Cardiac Myosins; Celecoxib; Cell Adhesion; Egtazic Acid; Enterocytes; ErbB Receptors; Focal Adhesion Kinase 2; GTP-Binding Protein alpha Subunits, G12-G13; Intestinal Mucosa; Intestine, Small; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Electron, Transmission; Mitogen-Activated Protein Kinase 1; Muscle Contraction; Muscle Relaxants, Central; Myosin Light Chains; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Quinazolines; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Sulfonamides; Tyrphostins; Up-Regulation

2006
Selective induction of cyclooxygenase-2 plays a role in lysophosphatidic acid regulated Fas ligand cell surface presentation.
    FEBS letters, 2006, Jan-23, Volume: 580, Issue:2

    Topics: Animals; Antigen Presentation; Antigens, Surface; Apoptosis; Aspirin; Cell Line, Tumor; Cell Membrane; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fas Ligand Protein; Female; Flavonoids; Humans; Lymphocyte Activation; Lymphocytes; Lysophospholipids; Membrane Glycoproteins; Nitrobenzenes; Ovarian Neoplasms; Quinazolines; Signal Transduction; Sulfonamides; Tumor Necrosis Factors; Tyrphostins

2006
Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis.
    Cancer research, 2006, Jan-01, Volume: 66, Issue:1

    Topics: Animals; Apoptosis; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; ErbB Receptors; Humans; Lapatinib; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Tyrphostins; Xenograft Model Antitumor Assays

2006
Inhibition of autophosphorylation of epidermal growth factor receptor by small peptides in vitro.
    British journal of pharmacology, 2006, Volume: 147, Issue:4

    Topics: Adenosine Triphosphate; Amino Acid Sequence; Binding Sites; Blotting, Western; Drug Interactions; Electrophoresis, Polyacrylamide Gel; ErbB Receptors; In Vitro Techniques; Molecular Sequence Data; Oligopeptides; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptor, Insulin; Tyrphostins

2006
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
    Biochemical and biophysical research communications, 2006, Mar-10, Volume: 341, Issue:2

    Topics: Androstadienes; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Infrared Rays; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; Radiation, Ionizing; Signal Transduction; src-Family Kinases; Temperature; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Wortmannin; X-Rays

2006
Vascular responses to alpha1-adrenergic receptors in small rat mesenteric arteries depend on mitochondrial reactive oxygen species.
    Arteriosclerosis, thrombosis, and vascular biology, 2006, Volume: 26, Issue:4

    Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Dipeptides; Doxycycline; ErbB Receptors; In Vitro Techniques; Matrix Metalloproteinase 7; Mesenteric Arteries; Mitochondria, Muscle; Phenylephrine; Quinazolines; Rats; Reactive Oxygen Species; Receptors, Adrenergic, alpha-1; Signal Transduction; Tyrphostins; Vasoconstriction; Vasoconstrictor Agents

2006
Metalloprotease-dependent amphiregulin release mediates tumor necrosis factor-alpha-induced IL-8 secretion in the human airway epithelial cell line NCI-H292.
    Life sciences, 2006, May-22, Volume: 78, Issue:26

    Topics: Amphiregulin; Antibodies, Blocking; Cell Line; Dipeptides; EGF Family of Proteins; Epithelial Cells; ErbB Receptors; Glycoproteins; Humans; Hydroxamic Acids; Immunoblotting; Intercellular Signaling Peptides and Proteins; Interleukin-8; Kinetics; Metalloproteases; Protease Inhibitors; Quinazolines; Transcriptional Activation; Tumor Necrosis Factor-alpha; Tyrphostins

2006
Peroxisome proliferator-activated receptor-gamma inhibits cigarette smoke solution-induced mucin production in human airway epithelial (NCI-H292) cells.
    American journal of physiology. Lung cellular and molecular physiology, 2006, Volume: 291, Issue:1

    Topics: Carcinoma, Mucoepidermoid; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; ErbB Receptors; Humans; Hypoglycemic Agents; Lung Neoplasms; Mucin 5AC; Mucins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; PPAR gamma; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Respiratory Mucosa; Rosiglitazone; Smoking; Thiazolidinediones; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins

2006
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
    The Journal of cell biology, 2006, Jan-30, Volume: 172, Issue:3

    Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Proliferation; Chromatin Immunoprecipitation; Chromones; Dermis; DNA; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression; Gene Expression Regulation; Hair Diseases; Integrases; Keratinocytes; Keratins; Ki-67 Antigen; MAP Kinase Signaling System; Mice; Mice, Transgenic; Morpholines; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Skin; Skin Abnormalities; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transforming Growth Factor alpha; Tyrphostins

2006
TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling.
    Experimental cell research, 2006, Apr-15, Volume: 312, Issue:7

    Topics: Animals; Cell Line; E-Box Elements; Enzyme Inhibitors; ErbB Receptors; Humans; MAP Kinase Kinase Kinases; Mutagenesis, Site-Directed; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; Signal Transduction; Transforming Growth Factor beta; Transforming Growth Factor beta1; Tyrphostins

2006
Galphaq expression activates EGFR and induces Akt mediated cardiomyocyte survival: dissociation from Galphaq mediated hypertrophy.
    Journal of molecular and cellular cardiology, 2006, Volume: 40, Issue:5

    Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gq-G11; Heart Ventricles; Hypertrophy; Myocardium; Myocytes, Cardiac; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Transcriptional Activation; Tyrphostins

2006
The invasive behaviour of prostatic cancer cells is suppressed by inhibitors of tyrosine kinase.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2006, Volume: 114, Issue:1

    Topics: Basement Membrane; Biological Assay; Carcinoma; Cell Movement; Collagen; Drug Combinations; Genistein; Humans; Laminin; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Neoplasm Invasiveness; Plasminogen; Plasminogen Activators; Prostatic Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteoglycans; Quinazolines; Tyrphostins

2006
A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling.
    Cancer research, 2006, Mar-01, Volume: 66, Issue:5

    Topics: Breast Neoplasms; Cell Line, Tumor; ErbB Receptors; Eukaryotic Initiation Factor-4E; Humans; Integrin alpha6beta4; Neoplasm Invasiveness; Phosphorylation; Protein Biosynthesis; Quinazolines; ras Proteins; Receptor, ErbB-2; RNA, Small Interfering; Signal Transduction; Transcriptional Activation; Transfection; Tyrphostins

2006
Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase.
    Biochemical pharmacology, 2006, May-14, Volume: 71, Issue:10

    Topics: Animals; Area Under Curve; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Injections, Intravenous; Injections, Subcutaneous; Mice; Molecular Structure; Protein Tyrosine Phosphatases; Quinazolines; Rats; Thymidine; Tyrphostins; Xenograft Model Antitumor Assays

2006
PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.
    Oncology reports, 2006, Volume: 15, Issue:4

    Topics: Cell Line, Tumor; Cell Movement; Dipeptides; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Kidney Neoplasms; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Oligopeptides; Phosphorylation; Pyrroles; Quinazolines; Receptor, PAR-1; Thrombin; Tyrosine; Tyrphostins

2006
Inhibition of epidermal growth factor receptor activation enhances in vivo histamine-stimulated gastric acid secretion in the rat.
    Digestive diseases and sciences, 2006, Volume: 51, Issue:2

    Topics: Animals; ErbB Receptors; Gastric Acid; Histamine; Histamine H2 Antagonists; Male; Phosphorylation; Quinazolines; Ranitidine; Rats; Rats, Sprague-Dawley; Transforming Growth Factor alpha; Tyrphostins

2006
Aldosterone stimulates activity and surface expression of NHE3 in human primary proximal tubule epithelial cells (RPTEC).
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2006, Volume: 17, Issue:1-2

    Topics: Aldosterone; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Humans; Kidney Tubules, Proximal; Quinazolines; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Tyrphostins

2006
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.
    Toxicology letters, 2006, Aug-20, Volume: 165, Issue:2

    Topics: Adult; Benzo(a)pyrene; Calcium; Calcium Signaling; Carcinogens, Environmental; Cells, Cultured; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Female; Genistein; Humans; Myometrium; Oxytocin; Pregnancy; Protein-Tyrosine Kinases; Quinazolines; Tetraethylammonium; Tyrphostins

2006
Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor.
    Kidney international, 2006, Volume: 69, Issue:10

    Topics: Angiotensin II; Animals; Arachidonic Acid; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Glutathione Transferase; Kidney Tubules, Proximal; Kinetics; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Quinazolines; Rabbits; Recombinant Fusion Proteins; Transcriptional Activation; Tyrphostins

2006
Activation of the lutropin/choriogonadotropin receptor in MA-10 cells stimulates tyrosine kinase cascades that activate ras and the extracellular signal regulated kinases (ERK1/2).
    Endocrinology, 2006, Volume: 147, Issue:7

    Topics: Animals; Cell Line; Chorionic Gonadotropin; Enzyme Activation; Genes, Dominant; Humans; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein-Tyrosine Kinases; Quinazolines; ras GTPase-Activating Proteins; ras Proteins; Receptors, LH; Tyrphostins

2006
Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK.
    Journal of lipid research, 2006, Volume: 47, Issue:7

    Topics: Animals; Apoptosis; Cell Differentiation; Culture Media, Serum-Free; ErbB Receptors; Grifola; GTP-Binding Protein alpha Subunits, Gi-Go; Lysophospholipids; MAP Kinase Signaling System; Nerve Growth Factors; Neurites; Neurons; Neuroprotective Agents; PC12 Cells; Quinazolines; Rats; Tyrphostins

2006
HER2 expression as a potential marker for response to therapy targeted to the EGFR.
    British journal of cancer, 2006, Apr-24, Volume: 94, Issue:8

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Laser Scanning Cytometry; Mitogen-Activated Protein Kinases; Phosphorylation; Predictive Value of Tests; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Sensitivity and Specificity; Structure-Activity Relationship; Trastuzumab; Tyrphostins

2006
Tyrosine kinase inhibitors alter adhesivity of prostatic cancer cells to extracellular matrix components.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2006, Volume: 114, Issue:3

    Topics: Cell Adhesion; Cell Line, Tumor; Cell Survival; Extracellular Matrix; Genistein; Humans; Integrins; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2006
Urokinase plasminogen activator receptor (uPAR) expression is reduced by tyrosine kinase inhibitors.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2006, Volume: 114, Issue:4

    Topics: Adenocarcinoma; Cell Line, Tumor; Gene Expression; Genistein; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; RNA, Messenger; Tyrphostins

2006
EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteins.
    Oncogene, 2006, Oct-19, Volume: 25, Issue:49

    Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Survival; Cell Transformation, Neoplastic; Cells, Cultured; CHO Cells; Cricetinae; Down-Regulation; ErbB Receptors; Humans; Mice; NIH 3T3 Cells; Protein Binding; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-cbl; Quinazolines; Transfection; Tyrphostins; Ubiquitin

2006
Transcription levels of invasion-related genes in prostate cancer cells are modified by inhibitors of tyrosine kinase.
    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2006, Volume: 114, Issue:5

    Topics: Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Genistein; Humans; Male; Metalloproteases; Prostatic Neoplasms; Protein Array Analysis; Protein-Tyrosine Kinases; Quinazolines; RNA, Messenger; Transcription, Genetic; Tyrphostins; Urokinase-Type Plasminogen Activator

2006
Gefitinib prevents bleomycin-induced lung fibrosis in mice.
    American journal of respiratory and critical care medicine, 2006, Sep-01, Volume: 174, Issue:5

    Topics: Animals; Bleomycin; Cell Culture Techniques; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Fibroblasts; Gefitinib; Humans; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors; Pulmonary Fibrosis; Quinazolines; Tyrphostins

2006
Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells.
    International journal of oncology, 2006, Volume: 29, Issue:1

    Topics: Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Leuprolide; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Time Factors; Tyrphostins

2006
STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells.
    Kidney international, 2006, Volume: 70, Issue:4

    Topics: Animals; Cell Line; Cell Survival; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Hydrogen Peroxide; Janus Kinase 2; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred Strains; Oxidative Stress; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Tyrosine; Tyrphostins

2006
Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.
    European journal of pharmacology, 2006, Aug-07, Volume: 542, Issue:1-3

    Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Antibodies; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Endothelin-1; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Norepinephrine; Phenylalanine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Thiophenes; Tyrphostins; Wortmannin

2006
[Involvement of epidermal growth factor receptor signaling pathway in tamoxifen resistance of MCF-7 cells].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:7

    Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Quinazolines; Receptors, Estrogen; RNA, Messenger; Signal Transduction; Tamoxifen; Tyrphostins

2006
GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.
    Molecular reproduction and development, 2006, Volume: 73, Issue:10

    Topics: Animals; Cell Adhesion Molecules; Cyclooxygenase 2; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Female; Glucuronosyltransferase; Gonadotropin-Releasing Hormone; Hyaluronan Synthases; Meiosis; Ovarian Follicle; Ovulation; Phosphorylation; Progesterone; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Tyrphostins

2006
[Oxidized glutathione induces activation of the epidermal growth factor receptor and MAP kinases ERK 1,2].
    Tsitologiia, 2006, Volume: 48, Issue:6

    Topics: Animals; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Glutathione Disulfide; Humans; Mice; Mitogen-Activated Protein Kinase 1; NIH 3T3 Cells; Oligopeptides; Quinazolines; Transcriptional Activation; Tyrphostins

2006
Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor.
    FEBS letters, 2006, Sep-04, Volume: 580, Issue:20

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Survival; Cetuximab; Cisplatin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Head and Neck Neoplasms; Humans; Phosphorylation; Quinazolines; Tyrosine; Tyrphostins

2006
Activation of insulin-like growth factor type-1 receptor is required for H2O2-induced PKB phosphorylation in vascular smooth muscle cells.
    Canadian journal of physiology and pharmacology, 2006, Volume: 84, Issue:7

    Topics: Animals; Cell Line; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Focal Adhesion Kinase 2; Hydrogen Peroxide; Immunoblotting; Insulin-Like Growth Factor I; Models, Biological; Muscle, Smooth, Vascular; Oxidants; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Receptor, IGF Type 1; src-Family Kinases; Tyrosine; Tyrphostins

2006
EGFR-activated signaling and actin remodeling regulate cyclic stretch-induced NRF2-ARE activation.
    American journal of respiratory cell and molecular biology, 2007, Volume: 36, Issue:3

    Topics: Actins; Animals; Antioxidants; Chromones; Endothelial Cells; Epithelial Cells; ErbB Receptors; Gene Expression Regulation; Lung; Mice; Morpholines; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Response Elements; RNA, Messenger; Signal Transduction; Stress, Mechanical; Transcription, Genetic; Tyrphostins

2007
Maximal beta3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation.
    The Journal of biological chemistry, 2006, Dec-08, Volume: 281, Issue:49

    Topics: 3T3-L1 Cells; Adipocytes; Adrenergic beta-3 Receptor Agonists; Animals; Cyclic AMP-Dependent Protein Kinases; Dioxoles; Enzyme Activation; ErbB Receptors; Estradiol; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Isoquinolines; Lipolysis; Mice; Quinazolines; Receptors, Adrenergic, beta-3; RNA, Small Interfering; src-Family Kinases; Sulfonamides; Tyrphostins

2006
The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor AG1478 increases the formation of inactive untethered EGFR dimers. Implications for combination therapy with monoclonal antibody 806.
    The Journal of biological chemistry, 2007, Feb-02, Volume: 282, Issue:5

    Topics: Animals; Antibodies, Monoclonal; Cell Division; Cell Line, Tumor; Dimerization; ErbB Receptors; Flow Cytometry; Humans; Kinetics; Mice; Mice, Nude; Protein-Tyrosine Kinases; Quinazolines; Transplantation, Heterologous; Tyrphostins

2007
Extracellular signal-regulated kinase activation by parathyroid hormone in distal tubule cells.
    American journal of physiology. Renal physiology, 2007, Volume: 292, Issue:3

    Topics: Animals; Cell Line; Cells, Cultured; Culture Media, Conditioned; Dipeptides; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Distal; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Parathyroid Hormone; Peptide Fragments; Pertussis Toxin; Phosphoproteins; Phosphorylation; Quinazolines; Receptor, Parathyroid Hormone, Type 1; Receptors, Cell Surface; Sodium-Hydrogen Exchangers; Transfection; Tyrphostins

2007
Signaling of mitochondrial biogenesis following oxidant injury.
    The Journal of biological chemistry, 2007, Jan-26, Volume: 282, Issue:4

    Topics: Animals; Cells, Cultured; ErbB Receptors; Female; Kidney Tubules, Proximal; Mitochondria; Oxidants; Oxidative Stress; Quinazolines; Rabbits; Regeneration; Reperfusion Injury; Signal Transduction; tert-Butylhydroperoxide; Transcription Factors; Tyrphostins

2007
Skeletal muscle stem cells express anti-apoptotic ErbB receptors during activation from quiescence.
    Experimental cell research, 2007, Jan-15, Volume: 313, Issue:2

    Topics: Animals; Apoptosis; Benzothiazoles; Cell Survival; Humans; Ligands; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Muscle Cells; Protein Kinase Inhibitors; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Satellite Cells, Skeletal Muscle; Signal Transduction; Stem Cells; Tyrphostins

2007
Transactivation of EGFR mediates insulin-stimulated ERK1/2 activation and enhanced cell migration in human corneal epithelial cells.
    Molecular vision, 2006, Nov-16, Volume: 12

    Topics: Cell Line, Transformed; Cell Movement; Cytoskeleton; Dipeptides; Enzyme Activation; Epithelium, Corneal; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Insulin; Isoenzymes; Metalloendopeptidases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protease Inhibitors; Quinazolines; Transcriptional Activation; Tyrphostins; Wound Healing

2006
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
    Endocrine-related cancer, 2006, Volume: 13, Issue:4

    Topics: Adenocarcinoma, Follicular; Aprotinin; Blotting, Western; Carcinoma, Papillary; Cell Differentiation; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Protease Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Serine Proteinase Inhibitors; Tetracyclines; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrphostins

2006
Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.
    Journal of cellular physiology, 2007, Volume: 211, Issue:3

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line, Tumor; CpG Islands; DNA Methylation; Enzyme Inhibitors; ErbB Receptors; Female; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Ovarian Neoplasms; Quinazolines; Receptors, Retinoic Acid; RNA Processing, Post-Transcriptional; Transcription, Genetic; Tyrphostins; Up-Regulation

2007
Nicotine-induced vascular endothelial growth factor release via the EGFR-ERK pathway in rat vascular smooth muscle cells.
    Life sciences, 2007, Mar-20, Volume: 80, Issue:15

    Topics: Animals; Blotting, Western; Butadienes; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Hexamethonium; Muscle, Smooth, Vascular; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nitriles; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tyrphostins; Vascular Endothelial Growth Factor A

2007
Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:6

    Topics: Animals; Bacterial Proteins; Cell Proliferation; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Pulmonary Veins; Quinazolines; Sheep; Signal Transduction; Time Factors; Transfection; Tyrphostins

2007
Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness.
    Cancer science, 2007, Volume: 98, Issue:5

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Blotting, Western; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Chromones; Enzyme Inhibitors; Gene Expression; Glioma; Gliosarcoma; Humans; Hydroxamic Acids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Morpholines; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Transfection; Tyrphostins

2007
EGF receptor is involved in WNT3a-mediated proliferation and motility of NIH3T3 cells via ERK pathway activation.
    Cellular signalling, 2007, Volume: 19, Issue:7

    Topics: Animals; beta Catenin; Cell Movement; Cell Proliferation; Cytoskeleton; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Intercellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase Kinases; NIH 3T3 Cells; Quinazolines; raf Kinases; ras Proteins; RNA, Small Interfering; Tyrphostins; Wnt Proteins; Wnt3 Protein; Wnt3A Protein

2007
Epiregulin promotes proliferation and migration of renal proximal tubular cells.
    American journal of physiology. Renal physiology, 2007, Volume: 293, Issue:1

    Topics: Animals; Blotting, Western; Butadienes; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rabbits; Tyrphostins; Wound Healing

2007
Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.
    Toxicology and applied pharmacology, 2007, May-15, Volume: 221, Issue:1

    Topics: Antimony; Arsenites; beta Catenin; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Line, Transformed; Cell Proliferation; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Humans; Insulin; Keratinocytes; Male; Matrix Metalloproteinase 7; PPAR delta; Pyrimidines; Quinazolines; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tyrphostins

2007
The control of tissue architecture over nuclear organization is crucial for epithelial cell fate.
    Journal of cell science, 2007, May-01, Volume: 120, Issue:Pt 9

    Topics: Antigens, Neoplasm; Antigens, Nuclear; Apoptosis; beta Catenin; Cell Culture Techniques; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Nucleus; Cell Polarity; Chromones; Collagen Type IV; Enzyme Inhibitors; Epigenesis, Genetic; Epithelial Cells; ErbB Receptors; Histones; Humans; Integrin alpha6; Ki-67 Antigen; Membrane Proteins; Morpholines; Mucin-1; Mucins; Neoplasm Proteins; Nuclear Matrix-Associated Proteins; Nuclear Proteins; Phosphoproteins; Promyelocytic Leukemia Protein; Quinazolines; RNA, Small Interfering; Transcription Factors; Tumor Suppressor Proteins; Tyrphostins; Zonula Occludens-1 Protein

2007
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.
    The Biochemical journal, 2007, Jul-15, Volume: 405, Issue:2

    Topics: Acetophenones; Animals; Anthracenes; Benzamides; Chromones; Dioxoles; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heparin-binding EGF-like Growth Factor; Hepatocytes; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Morpholines; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Onium Compounds; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Transforming Growth Factor beta; Tyrphostins; Up-Regulation

2007
Activation of mitogen-activated protein kinase by hepatocyte growth factor is stimulated by both alpha1- and beta2-adrenergic agonists in primary cultures of adult rat hepatocytes.
    Journal of pharmacological sciences, 2007, Volume: 103, Issue:4

    Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Adrenergic beta-2 Receptor Agonists; Androstadienes; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Hepatocyte Growth Factor; Hepatocytes; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Models, Biological; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Sphingosine; Tyrphostins; Wortmannin

2007
Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.
    Endocrinology, 2007, Volume: 148, Issue:7

    Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Dipeptides; Epidermal Growth Factor; Flavonoids; Immunohistochemistry; Inositol Phosphates; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyrazoles; Pyrimidines; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Steroids; Tyrphostins

2007
Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway.
    Cancer science, 2007, Volume: 98, Issue:4

    Topics: Adenocarcinoma; Cell Adhesion; Cell Hypoxia; Cell Line, Tumor; Cell Movement; ErbB Receptors; Humans; Lung Neoplasms; Oligonucleotide Array Sequence Analysis; Quinazolines; Signal Transduction; Tyrphostins

2007
Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1.
    Chest, 2007, Volume: 131, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Bronchi; Bronchial Neoplasms; Carcinoma, Mucoepidermoid; Cell Line, Tumor; Chloride Channels; ErbB Receptors; Gene Expression; Humans; Male; Mucin 5AC; Mucins; Niflumic Acid; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smoking; Tyrphostins

2007
Epidermal growth factor receptor is not required for human cytomegalovirus entry or signaling.
    Journal of virology, 2007, Volume: 81, Issue:12

    Topics: Cell Fusion; Cell Line; Cytomegalovirus; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Fibroblasts; Humans; Neutralization Tests; Quinazolines; Signal Transduction; Time Factors; Tyrphostins; Viral Proteins; Virus Internalization

2007
ERK-dependent and -independent pathways trigger human neural progenitor cell migration.
    Toxicology and applied pharmacology, 2007, May-15, Volume: 221, Issue:1

    Topics: Astrocytes; Blotting, Western; Cell Differentiation; Cell Movement; Cell Survival; Cells, Cultured; Flavonoids; Humans; Indoles; Maleimides; Methylmercury Compounds; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Protein Kinase C; Pyrimidines; Quinazolines; Signal Transduction; Spheroids, Cellular; src-Family Kinases; Stem Cells; Sulfonamides; Tetradecanoylphorbol Acetate; Tyrphostins

2007
Insulin-like growth factor-I (IGF-I) induces epidermal growth factor receptor transactivation and cell proliferation through reactive oxygen species.
    Free radical biology & medicine, 2007, Jun-01, Volume: 42, Issue:11

    Topics: Animals; Aorta; Cell Proliferation; Cells, Cultured; ErbB Receptors; Insulin-Like Growth Factor I; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; src-Family Kinases; Transcriptional Activation; Tyrphostins

2007
Dynamic and differential regulation of NKCC1 by calcium and cAMP in the native human colonic epithelium.
    The Journal of physiology, 2007, Jul-15, Volume: 582, Issue:Pt 2

    Topics: Acetylcholine; Adult; Aged; Aged, 80 and over; Calcium; Calcium Signaling; Chloroquine; Cholinergic Agents; Colforsin; Colon; Cyclic AMP; ErbB Receptors; Humans; Intestinal Mucosa; Lysosomes; Middle Aged; Protein Synthesis Inhibitors; Quinazolines; Receptor, Muscarinic M3; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Tissue Distribution; Tyrphostins

2007
Effect of combining epidermal growth factor receptor inhibitors and cisplatin on proliferation and apoptosis of oral squamous cell carcinoma cells.
    International journal of oncology, 2007, Volume: 30, Issue:6

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cetuximab; Cisplatin; Enzyme Inhibitors; ErbB Receptors; Humans; Inhibitor of Apoptosis Proteins; Mouth Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins

2007
The neuregulin-1 receptor erbB4 controls glutamatergic synapse maturation and plasticity.
    Neuron, 2007, May-24, Volume: 54, Issue:4

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Drug Interactions; Enzyme Inhibitors; ErbB Receptors; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Microscopy, Confocal; N-Methylaspartate; Neuregulin-1; Neuronal Plasticity; Neurons; Patch-Clamp Techniques; Quinazolines; Rats; Receptor, ErbB-4; RNA Interference; RNA, Small Interfering; Synapses; Synaptic Transmission; Transfection; Tyrphostins

2007
Depolarization-induced, glutamate receptor-mediated, and transactivation-dependent extracellular-signal regulated kinase phosphorylation in cultured cerebellar granule neurons.
    Neuroscience, 2007, Jun-29, Volume: 147, Issue:2

    Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasmic Granules; Dipeptides; Enzyme Inhibitors; ErbB Receptors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; Heparin Antagonists; Metalloproteases; Mice; Neurons; Phosphorylation; Potassium; Protease Inhibitors; Protein-Tyrosine Kinases; Quinazolines; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcriptional Activation; Tyrphostins

2007
EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes.
    Molecular reproduction and development, 2008, Volume: 75, Issue:1

    Topics: Adenosine Monophosphate; Amphiregulin; Animals; Cells, Cultured; Cumulus Cells; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Glycoproteins; Intercellular Signaling Peptides and Proteins; Meiosis; Mice; Oocytes; Peptides; Protein Kinase C; Quinazolines; Tyrphostins

2008
Heparin-binding EGF-like growth factor mediates oxyhemoglobin-induced suppression of voltage-dependent potassium channels in rabbit cerebral artery myocytes.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:3

    Topics: Animals; Cerebral Arteries; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Metalloproteases; Myocytes, Smooth Muscle; Oxyhemoglobins; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Protein Kinase C; Quinazolines; Rabbits; Tyrphostins

2007
Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2007, Volume: 293, Issue:3

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Dose-Response Relationship, Drug; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Ileum; Imidazoles; Mitochondria; Mitogen-Activated Protein Kinase 14; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinazolines; Rats; RNA Interference; RNA, Small Interfering; Signal Transduction; Time Factors; Tyrphostins

2007
Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes.
    American journal of physiology. Lung cellular and molecular physiology, 2007, Volume: 293, Issue:4

    Topics: Adenosine Triphosphate; Animals; Antibodies; Autocrine Communication; Benzothiazoles; Biological Transport; Cell Movement; Cell Proliferation; Cells, Cultured; Drug Synergism; Electric Conductivity; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; KCNQ1 Potassium Channel; Male; Pinacidil; Potassium; Potassium Channels; Protein Kinase Inhibitors; Pulmonary Alveoli; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Tyrphostins; Wound Healing

2007
Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes.
    Journal of cellular physiology, 2008, Volume: 214, Issue:2

    Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Cells, Cultured; Culture Media, Serum-Free; Cyclin D; Cyclins; Dinoprostone; DNA; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Gene Expression Regulation; Hepatocytes; Liver Neoplasms; Male; Pertussis Toxin; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tyrphostins

2008
Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway.
    The international journal of biochemistry & cell biology, 2007, Volume: 39, Issue:11

    Topics: Collagenases; Epithelial Cells; ErbB Receptors; Famotidine; Gene Expression Regulation, Enzymologic; Heparin-binding EGF-like Growth Factor; Histamine; Humans; Intercellular Signaling Peptides and Proteins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase Inhibitors; Quinazolines; RNA, Small Interfering; Stomach; Time Factors; Transcriptional Activation; Tyrphostins

2007
Activation of MEK-ERK by heregulin-beta1 promotes the development of cardiomyocytes derived from ES cells.
    Biochemical and biophysical research communications, 2007, Sep-28, Volume: 361, Issue:3

    Topics: Animals; Cell Differentiation; Embryonic Stem Cells; Extracellular Signal-Regulated MAP Kinases; Flow Cytometry; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Myocytes, Cardiac; Neuregulin-1; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Tyrphostins

2007
Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Animals; Aorta, Thoracic; Blotting, Northern; Blotting, Western; Butadienes; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Endothelin-1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Leptin; Male; Metalloendopeptidases; Myocytes, Smooth Muscle; Nitriles; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; RNA; RNA, Messenger; Signal Transduction; Transcriptional Activation; Tyrosine; Tyrphostins

2007
Epidermal growth factor receptor inhibitors enhance susceptibility to Fas-mediated apoptosis in oral squamous cell carcinoma cells.
    Oral oncology, 2008, Volume: 44, Issue:4

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 8; Cetuximab; Enzyme Inhibitors; ErbB Receptors; fas Receptor; Fas-Associated Death Domain Protein; Humans; Mouth Neoplasms; Neoplasm Proteins; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-akt; Quinazolines; Tumor Cells, Cultured; Tyrphostins

2008
Protease activated receptor 2 and epidermal growth factor receptor are involved in the regulation of human sperm motility.
    Asian journal of andrology, 2007, Volume: 9, Issue:5

    Topics: Ejaculation; Enzyme Inhibitors; ErbB Receptors; Humans; Male; Microscopy, Immunoelectron; Oligopeptides; Quinazolines; Receptor, PAR-2; Reference Values; Semen; Sperm Motility; Spermatozoa; Tyrphostins

2007
EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
    Cellular signalling, 2007, Volume: 19, Issue:12

    Topics: Animals; Apoptosis; Cell Survival; Cycloheximide; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibronectins; Integrin beta3; Intestinal Mucosa; MAP Kinase Kinase Kinases; Mice; Mutation; Oligopeptides; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphorylation; Polyamines; Protein Kinase Inhibitors; Putrescine; Pyrimidines; Quinazolines; Rats; Signal Transduction; src-Family Kinases; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins

2007
Thrombin increases hyposmotic taurine efflux and accelerates ICI-swell and RVD in 3T3 fibroblasts by a src-dependent EGFR transactivation.
    Pflugers Archiv : European journal of physiology, 2008, Volume: 455, Issue:5

    Topics: Animals; Calcium; Cell Size; Chloride Channels; Chlorides; Egtazic Acid; Enzyme Inhibitors; ErbB Receptors; Estrenes; Hemostatics; Mice; Osmotic Pressure; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Pyrimidines; Pyrrolidinones; Quinazolines; Signal Transduction; src-Family Kinases; Swiss 3T3 Cells; Taurine; Thrombin; Tritium; Tyrphostins

2008
Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor.
    Endocrinology, 2007, Volume: 148, Issue:12

    Topics: ADAM Proteins; ADAM17 Protein; Amphiregulin; Animals; Blotting, Western; Cells, Cultured; Cumulus Cells; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Flavonoids; Follicle Stimulating Hormone; Gene Expression; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oocytes; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Swine; Transfection; Tyrphostins

2007
Generation of novel, secreted epidermal growth factor receptor (EGFR/ErbB1) isoforms via metalloprotease-dependent ectodomain shedding and exosome secretion.
    Journal of cellular biochemistry, 2008, Apr-15, Volume: 103, Issue:6

    Topics: Biological Transport; Cell Line; Cell Membrane; Dipeptides; ErbB Receptors; Exocytosis; Humans; Intracellular Membranes; Metalloproteases; Phenylmercuric Acetate; Protein Isoforms; Protein Structure, Tertiary; Quinazolines; Signal Transduction; Tyrphostins

2008
Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Kidney; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Inbred WKY; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Tyrphostins; Vasoconstrictor Agents

2008
Ebselen, a redox regulator containing a selenium atom, induces neurofilament M expression in cultured rat pheochromocytoma PC12 cells via activation of mitogen-activated protein kinase.
    Journal of neuroscience research, 2008, Feb-15, Volume: 86, Issue:3

    Topics: Animals; Antioxidants; Azoles; Butadienes; Carbazoles; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Indole Alkaloids; Isoindoles; Mitogen-Activated Protein Kinases; Neurites; Neurofilament Proteins; Nitriles; Organoselenium Compounds; Oxidation-Reduction; PC12 Cells; Pertussis Toxin; Phosphorylation; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Selenium; Tyrphostins

2008
Lysophosphatidylcholine stimulates EGF receptor activation and mesangial cell proliferation: regulatory role of Src and PKC.
    Biochimica et biophysica acta, 2007, Volume: 1771, Issue:11

    Topics: Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Humans; Indoles; Lysophosphatidylcholines; Maleimides; MAP Kinase Signaling System; Mesangial Cells; Protein Kinase C; Quinazolines; src-Family Kinases; Tyrphostins

2007
Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity.
    Journal of cellular physiology, 2008, Volume: 215, Issue:1

    Topics: Animals; Cell Movement; Epidermal Growth Factor; Ion Channel Gating; Male; Prostatic Neoplasms; Quinazolines; Rats; Sodium Channels; Tetrodotoxin; Tyrphostins; Up-Regulation

2008
Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.
    The Journal of biological chemistry, 2008, Jan-04, Volume: 283, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Androstadienes; Angiotensin II; Animals; Cell Line; CHO Cells; Chromones; Cricetinae; Cricetulus; Gene Expression; Humans; Indoles; Maleimides; Membrane Glycoproteins; Morpholines; Mutation; NADPH Oxidase 1; NADPH Oxidase 2; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Protein Kinase C; Pyrazoles; Pyrimidines; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Superoxides; Tyrphostins; Wortmannin

2008
PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte.
    Domestic animal endocrinology, 2008, Volume: 34, Issue:4

    Topics: Animals; Butadienes; Cells, Cultured; Chromones; Cumulus Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Meiosis; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Swine; Tyrphostins

2008
Involvement of tyrosine kinase in the hyposmotic stimulation of I Ks in guinea-pig ventricular myocytes.
    Pflugers Archiv : European journal of physiology, 2008, Volume: 456, Issue:3

    Topics: Action Potentials; Animals; Cell Size; Delayed Rectifier Potassium Channels; Dose-Response Relationship, Drug; ErbB Receptors; Genistein; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Kinetics; Myocytes, Cardiac; Osmotic Pressure; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Pyrimidines; Quinazolines; Signal Transduction; src-Family Kinases; Tyrphostins; Vanadates

2008
In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.
    Digestive diseases and sciences, 2008, Volume: 53, Issue:8

    Topics: Amino Acid Transport System ASC; Androstadienes; Blotting, Western; Caco-2 Cells; Cell Membrane; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamine; Humans; Minor Histocompatibility Antigens; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; rho GTP-Binding Proteins; RNA Interference; Signal Transduction; Sodium; Time Factors; Tyrphostins; Up-Regulation; Wortmannin

2008
Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells.
    American journal of physiology. Renal physiology, 2008, Volume: 294, Issue:3

    Topics: ADAM Proteins; Animals; Autocrine Communication; Bacterial Proteins; Cell Movement; Cell Proliferation; Cells, Cultured; Dipeptides; Epithelial Cells; ErbB Receptors; Female; Heparin-binding EGF-like Growth Factor; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Matrix Metalloproteinases; Oxidative Stress; Paracrine Communication; Phosphorylation; Quinazolines; Rabbits; RNA, Small Interfering; src-Family Kinases; Tyrphostins; Wound Healing

2008
Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.
    Toxicology and applied pharmacology, 2008, Apr-15, Volume: 228, Issue:2

    Topics: Androstadienes; Blotting, Western; Cell Adhesion; Cell Line; Chromones; Dose-Response Relationship, Drug; E1A-Associated p300 Protein; ErbB Receptors; Humans; Lipopolysaccharides; Morpholines; Myocytes, Smooth Muscle; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Signal Transduction; src-Family Kinases; Trachea; Transfection; Tyrphostins; Vascular Cell Adhesion Molecule-1; Wortmannin

2008
Low-dose radiation stimulates the proliferation of normal human lung fibroblasts via a transient activation of Raf and Akt.
    Molecules and cells, 2007, Dec-31, Volume: 24, Issue:3

    Topics: Cell Proliferation; Chromones; Enzyme Activation; Fibroblasts; Gamma Rays; Humans; Lung; Morpholines; p21-Activated Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Quinazolines; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins

2007
Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.
    Molecular endocrinology (Baltimore, Md.), 2008, Volume: 22, Issue:4

    Topics: Amphiregulin; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipeptides; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Glycoproteins; Hydroxamic Acids; Immunohistochemistry; Immunoprecipitation; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Mice; Mitogen-Activated Protein Kinases; Oocytes; Ovarian Follicle; Phosphorylation; Protein Biosynthesis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrphostins

2008
Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle c
    Molecular pharmacology, 2008, Volume: 73, Issue:5

    Topics: Active Transport, Cell Nucleus; Antibodies; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Cell Adhesion; Cell Nucleus; Chromones; E1A-Associated p300 Protein; Enzyme Activation; Gene Expression Regulation; Histone Acetyltransferases; Histone Deacetylases; Humans; Isoenzymes; Morpholines; Myocytes, Smooth Muscle; Neutrophils; Phosphorylation; Promoter Regions, Genetic; Protein Kinase C; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Quinazolines; Repressor Proteins; Trachea; Tumor Necrosis Factor-alpha; Tyrphostins; Vascular Cell Adhesion Molecule-1

2008
TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.
    Journal of molecular and cellular cardiology, 2008, Volume: 44, Issue:3

    Topics: Animals; Blotting, Western; Cell Line; Cells, Cultured; ErbB Receptors; Mice; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Plasminogen Activator Inhibitor 1; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Rats; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Smad Proteins; Smad2 Protein; Transforming Growth Factor beta1; Tyrphostins

2008
TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype.
    Breast cancer research and treatment, 2009, Volume: 113, Issue:2

    Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Epithelium; ErbB Receptors; Female; Genes, erbB-2; Humans; Mesoderm; Neoplasm Proteins; Phenotype; Protein Kinase Inhibitors; Quinazolines; Receptors, Estrogen; Receptors, Progesterone; Receptors, TNF-Related Apoptosis-Inducing Ligand; Recombinant Fusion Proteins; RNA Interference; Tyrphostins

2009
Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.
    The Journal of biological chemistry, 2008, Apr-18, Volume: 283, Issue:16

    Topics: AC133 Antigen; Antigens, CD; Brain Neoplasms; Enzyme Inhibitors; Epidermal Growth Factor; Gefitinib; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Models, Biological; Peptides; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Stem Cells; Tumor Cells, Cultured; Tyrphostins

2008
Differential sensitivity of A549 non-small lung carcinoma cell responses to epidermal growth factor receptor pathway inhibitors.
    Cancer biology & therapy, 2008, Volume: 7, Issue:4

    Topics: Antibodies, Blocking; Antineoplastic Agents; Biological Assay; Carcinoma, Non-Small-Cell Lung; Cell Movement; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lung Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2008
Chronic pharmacologic inhibition of EGFR leads to cardiac dysfunction in C57BL/6J mice.
    Toxicology and applied pharmacology, 2008, May-01, Volume: 228, Issue:3

    Topics: Aminoquinolines; Aniline Compounds; Animals; Aortic Valve; Apoptosis; ErbB Receptors; Female; Heart; Heart Ventricles; Male; Mice; Mice, Inbred C57BL; Organic Chemicals; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Sex Characteristics; Tyrphostins

2008
EGFR inhibitor enhances cisplatin sensitivity of oral squamous cell carcinoma cell lines.
    Pathology oncology research : POR, 2008, Volume: 14, Issue:1

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Humans; Mouth Neoplasms; Quinazolines; Tyrphostins

2008
Inhibition of the EGF receptor blocks autocrine growth and increases the cytotoxic effects of doxorubicin in rat hepatoma cells: role of reactive oxygen species production and glutathione depletion.
    Biochemical pharmacology, 2008, May-15, Volume: 75, Issue:10

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Line, Tumor; Cells, Cultured; Doxorubicin; ErbB Receptors; Glutathione; Hepatocytes; Male; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Wistar; Reactive Oxygen Species; Tyrphostins

2008
MMP-12 induces IL-8/CXCL8 secretion through EGFR and ERK1/2 activation in epithelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 294, Issue:6

    Topics: Cell Line; ErbB Receptors; Genes, fos; Humans; Interleukin-8; Matrix Metalloproteinase 12; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Respiratory Mucosa; Tyrphostins

2008
EGFR signalling is required for Paracentrotus lividus endomesoderm specification.
    Archives of biochemistry and biophysics, 2008, Jun-01, Volume: 474, Issue:1

    Topics: Animals; Blotting, Western; Cell Lineage; Embryo, Nonmammalian; Endoderm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; MAP Kinase Signaling System; Mesoderm; Paracentrotus; Quinazolines; Signal Transduction; Tyrphostins

2008
Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes.
    The Journal of endocrinology, 2008, Volume: 197, Issue:2

    Topics: Animals; Cells, Cultured; Cumulus Cells; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Meiosis; Oocytes; Phosphorylation; Protein Kinase C; Quinazolines; Receptors, Androgen; Swine; Tetradecanoylphorbol Acetate; Tyrphostins

2008
Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.
    Microvascular research, 2008, Volume: 76, Issue:1

    Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Cinnamates; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; Neuropilin-1; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transplantation, Heterologous; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2

2008
Effects of gangliosides on the differentiation of human mesenchymal stem cells into osteoblasts by modulating epidermal growth factor receptors.
    Biochemical and biophysical research communications, 2008, Jul-11, Volume: 371, Issue:4

    Topics: Alkaline Phosphatase; Cell Differentiation; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Gangliosides; Humans; Mesenchymal Stem Cells; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2008
Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent.
    European journal of pharmacology, 2008, Jun-10, Volume: 587, Issue:1-3

    Topics: Animals; Astrocytes; Butadienes; Cell Size; Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Mice; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Quinazolines; Stimulation, Chemical; Transcriptional Activation; Tyrphostins; Vasopressins; Water

2008
Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.
    American journal of physiology. Cell physiology, 2008, Volume: 295, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Cell Line; Down-Regulation; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Ligands; Lysosomes; Macrolides; Phosphoproteins; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Quinazolines; Recombinant Fusion Proteins; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Tyrphostins

2008
Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.
    Journal of receptor and signal transduction research, 2008, Volume: 28, Issue:3

    Topics: Aminoquinolines; Aniline Compounds; Biological Assay; Drug Resistance; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Inhibitory Concentration 50; Morpholines; Mutant Proteins; Protein Kinase Inhibitors; Quinazolines; Substrate Specificity; Tyrphostins

2008
EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src.
    American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 295, Issue:3

    Topics: Adenosine Triphosphate; Bronchi; Cell Line; Chloride Channels; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Patch-Clamp Techniques; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Recombinant Proteins; Signal Transduction; Tyrphostins

2008
Arsenite suppresses Notch1 signaling in human keratinocytes.
    The Journal of investigative dermatology, 2009, Volume: 129, Issue:1

    Topics: Amyloid Precursor Protein Secretases; Arsenites; Calcium-Binding Proteins; Cell Differentiation; Enzyme Inhibitors; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Keratinocytes; Membrane Proteins; Models, Biological; Protein Binding; Quinazolines; Receptor, Notch1; Receptors, Notch; Serrate-Jagged Proteins; Signal Transduction; Skin Neoplasms; Tyrphostins

2009
The epidermal growth factor receptor mediates allergic airway remodelling in the rat.
    The European respiratory journal, 2008, Volume: 32, Issue:5

    Topics: Allergens; Animals; Cell Proliferation; Cysteine; ErbB Receptors; Gene Expression Profiling; Goblet Cells; Hyperplasia; Inflammation; Leukotriene D4; Muscle, Smooth; Ovalbumin; Quinazolines; Rats; Receptors, Leukotriene; Tyrphostins

2008
Insulin-induced epidermal growth factor activation in vascular smooth muscle cells is ADAM-dependent.
    Surgery, 2008, Volume: 144, Issue:2

    Topics: ADAM Proteins; Cell Movement; Cells, Cultured; Coronary Vessels; Dipeptides; ErbB Receptors; Fibrinolysin; Heparin-binding EGF-like Growth Factor; Humans; Insulin; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Phosphorylation; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Quinazolines; Receptor Cross-Talk; Signal Transduction; Somatomedins; Tyrphostins

2008
The transactivated epidermal growth factor receptor recruits Pyk2 to regulate Src kinase activity.
    The Journal of biological chemistry, 2008, Oct-10, Volume: 283, Issue:41

    Topics: Animals; Anticoagulants; Cell Line; Enzyme Inhibitors; ErbB Receptors; Focal Adhesion Kinase 2; Hemostatics; Heparin; Humans; Hydroxamic Acids; Ionomycin; Ionophores; Metalloproteases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Quinazolines; Rats; src-Family Kinases; Thrombin; Transcriptional Activation; Tyrphostins

2008
HER2 oncogenic function escapes EGFR tyrosine kinase inhibitors via activation of alternative HER receptors in breast cancer cells.
    PloS one, 2008, Aug-06, Volume: 3, Issue:8

    Topics: Betacellulin; Breast Neoplasms; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Female; Genes, erbB-2; Humans; Intercellular Signaling Peptides and Proteins; Neuregulin-1; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Tyrphostins

2008
Tyrphostin AG1478 suppresses proliferation and invasion of human breast cancer cells.
    International journal of oncology, 2008, Volume: 33, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme Inhibitors; ErbB Receptors; Female; Flow Cytometry; Gene Expression; Humans; Matrix Metalloproteinase 9; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Telomerase; Tyrphostins

2008
Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2008, Volume: 7, Issue:9

    Topics: Cell Line, Tumor; Cell Membrane; Cell Survival; Epidermal Growth Factor; ErbB Receptors; Humans; Lysosomes; Phosphorylation; Photosensitizing Agents; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2008
Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.
    Psychopharmacology, 2008, Volume: 201, Issue:3

    Topics: Aminopyridines; Animals; Antidepressive Agents, Second-Generation; Astrocytes; Butadienes; Calcium; Cells, Cultured; Chelating Agents; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fluorobenzenes; Fluoxetine; Gene Expression; Indoles; Maleimides; Mice; Nitriles; Phosphorylation; Piperidines; Protein Kinase C; Proto-Oncogene Proteins c-fos; Quinazolines; Receptor, Serotonin, 5-HT2B; RNA, Messenger; Signal Transduction; Substrate Specificity; Transcriptional Activation; Tyrphostins; Up-Regulation; Urea

2008
DNA vaccination controls Her-2+ tumors that are refractory to targeted therapies.
    Cancer research, 2008, Sep-15, Volume: 68, Issue:18

    Topics: Animals; Antibodies, Monoclonal; Cancer Vaccines; Cell Growth Processes; Female; Gefitinib; Karyotyping; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Quinazolines; Receptor, ErbB-2; Signal Transduction; T-Lymphocytes, Cytotoxic; Tyrphostins; Vaccines, DNA

2008
A novel small molecule regulator of guanine nucleotide exchange activity of the ADP-ribosylation factor and golgi membrane trafficking.
    The Journal of biological chemistry, 2008, Nov-07, Volume: 283, Issue:45

    Topics: Biological Transport, Active; Brefeldin A; Cell Line; Golgi Apparatus; Guanine Nucleotide Exchange Factors; Humans; Intracellular Membranes; Mutation; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Quinazolines; Tyrphostins

2008
Delta-opioid receptors activate ERK/MAP kinase via integrin-stimulated receptor tyrosine kinases.
    Cellular signalling, 2008, Volume: 20, Issue:12

    Topics: Cells, Cultured; Enkephalin, Leucine-2-Alanine; ErbB Receptors; Estrenes; Etorphine; Focal Adhesion Protein-Tyrosine Kinases; Humans; Integrins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oligopeptides; Phosphorylation; Protein Kinase C-delta; Pyrrolidinones; Quinazolines; Receptors, Opioid, delta; Type C Phospholipases; Tyrphostins

2008
Low density lipoproteins transactivate EGF receptor: role in mesangial cell proliferation.
    Life sciences, 2008, Oct-24, Volume: 83, Issue:17-18

    Topics: Animals; Cell Proliferation; Cells, Cultured; ErbB Receptors; Humans; Lipoproteins, LDL; MAP Kinase Signaling System; Mesangial Cells; Mice; Oxidative Stress; Phosphorylation; Quinazolines; ras Proteins; Tyrphostins

2008
The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.
    Biochimica et biophysica acta, 2009, Volume: 1793, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Isoenzymes; Liver Neoplasms; Mitochondria; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Rats; Reactive Oxygen Species; RNA, Small Interfering; Transforming Growth Factor beta; Tyrphostins

2009
A role for SNX5 in the regulation of macropinocytosis.
    BMC cell biology, 2008, Oct-14, Volume: 9

    Topics: Animals; Carrier Proteins; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophage Activation; Macrophages; Membrane Lipids; Membrane Proteins; Mice; Phosphatidylinositol Phosphates; Pinocytosis; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; Sorting Nexins; Transgenes; Tyrphostins; Vesicular Transport Proteins

2008
Therapeutic efficacy of 177Lu-CHX-A''-DTPA-hu3S193 radioimmunotherapy in prostate cancer is enhanced by EGFR inhibition or docetaxel chemotherapy.
    The Prostate, 2009, Jan-01, Volume: 69, Issue:1

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Cell Division; Cell Line, Tumor; Combined Modality Therapy; Docetaxel; Dose-Response Relationship, Radiation; Enzyme Inhibitors; ErbB Receptors; Humans; Isothiocyanates; Lutetium; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Pentetic Acid; Phosphorylation; Prostatic Neoplasms; Quinazolines; Radiation-Sensitizing Agents; Radioimmunotherapy; Radioisotopes; Taxoids; Tyrphostins; Xenograft Model Antitumor Assays

2009
Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.
    British journal of biomedical science, 2008, Volume: 65, Issue:3

    Topics: Adenocarcinoma; Amphiregulin; Autoantibodies; Cell Line, Tumor; Cell Proliferation; EGF Family of Proteins; ErbB Receptors; Esophageal Neoplasms; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Leptin; Matrix Metalloproteinases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transforming Growth Factor alpha; Tyrphostins

2008
c-Fos overexpression increases the proliferation of human hepatocytes by stabilizing nuclear Cyclin D1.
    World journal of gastroenterology, 2008, Nov-07, Volume: 14, Issue:41

    Topics: Cell Cycle; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Cyclin D1; Cyclin-Dependent Kinase Inhibitor Proteins; Cyclin-Dependent Kinases; Cycloheximide; ErbB Receptors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hepatocytes; Humans; Kinetics; Phosphorylation; Protein Kinase Inhibitors; Protein Stability; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; Transfection; Tyrphostins; Up-Regulation

2008
Receptor overexpression or inhibition alters cell surface dynamics of EGF-EGFR interaction: new insights from real-time single molecule analysis.
    Biochemical and biophysical research communications, 2009, Jan-16, Volume: 378, Issue:3

    Topics: Cell Membrane; Dimerization; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Microscopy, Fluorescence; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2009
Epidermal growth factor receptor is involved in enterocyte anoikis through the dismantling of E-cadherin-mediated junctions.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 296, Issue:2

    Topics: alpha Catenin; Animals; Anoikis; beta Catenin; Cadherins; Cell Adhesion; Endocytosis; Enterocytes; ErbB Receptors; Intestine, Small; Mice; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tight Junctions; Tyrphostins

2009
Stretching the search for therapeutic targets in acute lung injury.
    Translational research : the journal of laboratory and clinical medicine, 2008, Volume: 152, Issue:6

    Topics: Acute Lung Injury; Animals; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Humans; Protein Kinase Inhibitors; Quinazolines; Respiratory Distress Syndrome; Tyrphostins

2008
Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice.
    Translational research : the journal of laboratory and clinical medicine, 2008, Volume: 152, Issue:6

    Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Intubation, Intratracheal; Mice; Mice, Inbred Strains; Neutrophils; Permeability; Protein Tyrosine Phosphatases; Pulmonary Alveoli; Quinazolines; Signal Transduction; Tyrphostins; Ventilator-Induced Lung Injury; Ventilators, Mechanical

2008
Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling.
    Toxicology letters, 2009, Feb-10, Volume: 184, Issue:3

    Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic CMP; Dose-Response Relationship, Drug; Down-Regulation; Endocrine Disruptors; Enzyme Activators; Epidermal Growth Factor; ErbB Receptors; Genistein; Leydig Cells; Luteinizing Hormone; Male; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Long-Evans; Receptors, LH; Signal Transduction; Testosterone; Tyrphostins

2009
Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478.
    Biochemical pharmacology, 2009, Mar-01, Volume: 77, Issue:5

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Flow Cytometry; Humans; Immunohistochemistry; Neoplasm Proteins; Protein Kinase Inhibitors; Quinazolines; Tritium; Tyrphostins

2009
Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?
    The American journal of gastroenterology, 2009, Volume: 104, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Blotting, Western; Carcinoid Tumor; Celecoxib; Cell Line, Tumor; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; ErbB Receptors; Female; Humans; Insulinoma; Male; Mice; Mice, Transgenic; Middle Aged; Pancreatic Neoplasms; Pyrazoles; Quinazolines; Sulfonamides; Tumor Cells, Cultured; Tyrphostins; Young Adult

2009
Role of epidermal growth factor gene in the development of pancreatic cancer and efficiency of inhibitors of this gene in the treatment of pancreatic carcinoma.
    Bulletin of experimental biology and medicine, 2008, Volume: 145, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Proliferation; Drug Evaluation, Preclinical; Epidermal Growth Factor; ErbB Receptors; Fluorouracil; Gene Frequency; Genetic Predisposition to Disease; Humans; Pancreatic Neoplasms; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Quinazolines; Time Factors; Tumor Cells, Cultured; Tyrphostins

2008
Functions of epidermal growth factor receptor in cisplatin response of thyroid cells.
    Biochemical pharmacology, 2009, Mar-15, Volume: 77, Issue:6

    Topics: Animals; Apoptosis; Cell Line; Cisplatin; Dose-Response Relationship, Drug; ErbB Receptors; p38 Mitogen-Activated Protein Kinases; Quinazolines; Rats; Reactive Oxygen Species; Signal Transduction; Thyroid Gland; Tyrphostins

2009
Lysophosphatidic acid receptor 2 and Gi/Src pathway mediate cell motility through cyclooxygenase 2 expression in CAOV-3 ovarian cancer cells.
    Experimental & molecular medicine, 2008, Dec-31, Volume: 40, Issue:6

    Topics: Butadienes; Cell Line, Tumor; Cell Movement; CSK Tyrosine-Protein Kinase; Cyclooxygenase 2; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Nitriles; Ovarian Neoplasms; Pertussis Toxin; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrimidines; Quinazolines; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins

2008
The epidermal growth factor tyrosine kinase inhibitor AG1478 and erlotinib reverse ABCG2-mediated drug resistance.
    Oncology reports, 2009, Volume: 21, Issue:2

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Erlotinib Hydrochloride; Female; Humans; Mitoxantrone; Neoplasm Proteins; Quinazolines; Tyrphostins

2009
Dexamethasone enhances basal and TNF-alpha-stimulated production of PAI-1 via the glucocorticoid receptor regardless of 11beta-hydroxysteroid dehydrogenase 2 status in human proximal renal tubular cells.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:6

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 2; Aldosterone; Cells, Cultured; Dexamethasone; Fibrosis; Humans; Kidney Tubules, Proximal; Plasminogen Activator Inhibitor 1; Protein-Tyrosine Kinases; Quinazolines; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; RNA, Messenger; Tumor Necrosis Factor-alpha; Tyrphostins

2009
Epidermal growth factor receptor lacking C-terminal autophosphorylation sites retains signal transduction and high sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor.
    Cancer science, 2009, Volume: 100, Issue:3

    Topics: Blotting, Western; Cell Line; Enzyme Inhibitors; ErbB Receptors; Humans; Immunoprecipitation; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Transfection; Tyrosine; Tyrphostins

2009
Chronic intermittent mechanical stress increases MUC5AC protein expression.
    American journal of respiratory cell and molecular biology, 2009, Volume: 41, Issue:4

    Topics: Bronchi; Bronchoconstriction; Cells, Cultured; Epithelial Cells; ErbB Receptors; Forkhead Transcription Factors; Gene Expression Regulation; Hepatocyte Nuclear Factor 3-beta; Humans; Microtubule Proteins; Mucin 5AC; Protein Kinase Inhibitors; Quinazolines; Stress, Mechanical; Transcription, Genetic; Transforming Growth Factor beta2; Tyrphostins

2009
Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase.
    The FEBS journal, 2009, Volume: 276, Issue:5

    Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dual Specificity Phosphatase 1; ErbB Receptors; Humans; JNK Mitogen-Activated Protein Kinases; Lung Neoplasms; Mice; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Tyrphostins

2009
Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma.
    The Journal of biological chemistry, 2009, Apr-10, Volume: 284, Issue:15

    Topics: Active Transport, Cell Nucleus; Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Squamous Cell; Cell Line, Tumor; Cobalt; Cyclooxygenase 2; Epidermal Growth Factor; Female; Humans; Microscopy, Fluorescence; Models, Biological; Promoter Regions, Genetic; Quinazolines; RNA, Messenger; Tyrphostins; Uterine Cervical Neoplasms

2009
Epidermal growth factor receptor is involved in clusterin-induced astrocyte proliferation.
    Neuroreport, 2009, Mar-04, Volume: 20, Issue:4

    Topics: Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Clusterin; Enzyme Activation; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogens; Phosphorylation; Proto-Oncogene Proteins c-raf; Quinazolines; Rats; RNA, Small Interfering; Signal Transduction; Tyrphostins

2009
Desmoid cell motility is induced in vitro by rhEGF.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2009, Volume: 27, Issue:9

    Topics: Benzamides; Cell Division; Cell Line, Tumor; Cell Movement; Culture Media, Serum-Free; Dioxoles; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibromatosis, Aggressive; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Integrin beta1; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Quinazolines; Receptors, Transforming Growth Factor beta; Recombinant Proteins; RNA, Messenger; RNA, Small Interfering; Soft Tissue Neoplasms; STAT3 Transcription Factor; Transforming Growth Factor alpha; Tyrphostins

2009
Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium.
    American journal of respiratory cell and molecular biology, 2009, Volume: 41, Issue:6

    Topics: Brefeldin A; Bumetanide; Cell Line; Chlorides; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Humans; Ion Transport; Protein-Tyrosine Kinases; Quercetin; Quinazolines; Respiratory Mucosa; Signal Transduction; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Tyrphostins; Valinomycin

2009
Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro.
    American journal of physiology. Endocrinology and metabolism, 2009, Volume: 296, Issue:5

    Topics: Amphiregulin; Animals; Betacellulin; Cumulus Cells; EGF Family of Proteins; Embryonic Development; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Fertilization in Vitro; Glycoproteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Macaca mulatta; Oocytes; Phosphorylation; Pregnancy; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrphostins

2009
Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.
    Journal of vascular surgery, 2009, Volume: 49, Issue:5

    Topics: Aged; Ankle; Becaplermin; Blood Pressure; Cell Proliferation; Cells, Cultured; Constriction, Pathologic; DNA Replication; Epidermal Growth Factor; Female; Fibroblasts; Graft Occlusion, Vascular; Heparin; Humans; Hyperplasia; Lower Extremity; Lysophospholipids; Male; Middle Aged; Myocytes, Smooth Muscle; Peripheral Vascular Diseases; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Saphenous Vein; Sphingosine; Thrombin; Time Factors; Tyrphostins; Ultrasonography, Doppler, Duplex; Vascular Patency

2009
Activation of the calcium-sensing receptor by high calcium induced breast cancer cell proliferation and TRPC1 cation channel over-expression potentially through EGFR pathways.
    Archives of biochemistry and biophysics, 2009, Jun-01, Volume: 486, Issue:1

    Topics: Base Sequence; Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Dipeptides; DNA Primers; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Receptors, Calcium-Sensing; Transcriptional Activation; TRPC Cation Channels; Tyrphostins

2009
Estradiol, progesterone, and transforming growth factor alpha regulate insulin-like growth factor binding protein-3 (IGFBP3) expression in mouse endometrial cells.
    Zoological science, 2009, Volume: 26, Issue:2

    Topics: Animals; Blotting, Western; DNA; Endometrium; Enzyme Inhibitors; Epithelial Cells; Estradiol; Female; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Mice; Mice, Inbred ICR; Progesterone; Quinazolines; Receptor, IGF Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Transforming Growth Factor alpha; Tyrphostins

2009
A role for Gab1/SHP2 in thrombin activation of PAK1: gene transfer of kinase-dead PAK1 inhibits injury-induced restenosis.
    Circulation research, 2009, May-08, Volume: 104, Issue:9

    Topics: Angioplasty, Balloon; Animals; Carotid Artery Diseases; Carotid Stenosis; cdc42 GTP-Binding Protein; Cell Movement; Cells, Cultured; Disease Models, Animal; ErbB Receptors; Fibrinolytic Agents; Gene Transfer Techniques; Genetic Therapy; Guanine Nucleotide Exchange Factors; Hirudins; Humans; Muscle, Smooth, Vascular; Mutation; p21-Activated Kinases; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Quinazolines; rac1 GTP-Binding Protein; Rats; Rho Guanine Nucleotide Exchange Factors; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Stress Fibers; Thrombin; Time Factors; Transfection; Tyrphostins

2009
Receptor tyrosine kinases as mediators of injury-induced bradykinin B1 receptor expression in rabbit aortic smooth muscle.
    European journal of pharmacology, 2009, Mar-15, Volume: 606, Issue:1-3

    Topics: Animals; Aorta; Bradykinin; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Interleukin-1; Muscle Contraction; Myocytes, Smooth Muscle; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Receptor, Bradykinin B1; Tyrphostins; Up-Regulation

2009
Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells.
    Lung cancer (Amsterdam, Netherlands), 2010, Volume: 67, Issue:1

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Drug Resistance, Neoplasm; ErbB Receptors; Heme Oxygenase-1; Humans; Lung Neoplasms; Protein Kinase Inhibitors; Quinazolines; RNA, Small Interfering; Tyrphostins

2010
EGF-induced MMP-9 expression is mediated by the JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line.
    Cellular signalling, 2009, Volume: 21, Issue:6

    Topics: Breast Neoplasms; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Matrix Metalloproteinase 9; Phosphorylation; Quinazolines; RNA, Messenger; RNA, Small Interfering; STAT3 Transcription Factor; Tyrphostins

2009
Regulation and function of tissue inhibitor of metalloproteinase (TIMP) 1 and TIMP3 in periovulatory rat granulosa cells.
    Endocrinology, 2009, Volume: 150, Issue:8

    Topics: Adenylyl Cyclases; Animals; Blotting, Western; Cell Survival; Cells, Cultured; Chorionic Gonadotropin; Colforsin; Enzyme Inhibitors; Female; Granulosa Cells; Hormone Antagonists; Humans; Mifepristone; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Protein Kinase C; Protein Tyrosine Phosphatases; Quinazolines; Rats; Receptors, Progesterone; Reproductive Control Agents; RNA, Small Interfering; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3; Tyrphostins

2009
Cell migration in response to the amino-terminal fragment of urokinase requires epidermal growth factor receptor activation through an ADAM-mediated mechanism.
    Journal of vascular surgery, 2009, Volume: 49, Issue:5

    Topics: ADAM Proteins; ADAM10 Protein; Amyloid Precursor Protein Secretases; Cell Movement; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Humans; Hydroxamic Acids; Membrane Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Peptide Fragments; Phosphorylation; Protease Inhibitors; Protein Kinase Inhibitors; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Time Factors; Tyrphostins; Urokinase-Type Plasminogen Activator

2009
Downregulation of Notch1 and its potential correlation with epidermal growth factor receptor signalling in tongue squamous cell carcinoma.
    The British journal of oral & maxillofacial surgery, 2010, Volume: 48, Issue:1

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; ErbB Receptors; Gene Silencing; Humans; Inverted Repeat Sequences; Metaplasia; Mouth Mucosa; Plasmids; Quinazolines; Receptor, Notch1; RNA; Signal Transduction; Tongue; Tongue Neoplasms; Transfection; Tyrphostins; Up-Regulation

2010
Role of epidermal growth factor receptor (EGFR) in corneal remodelling in diabetes.
    Acta ophthalmologica, 2009, Volume: 87, Issue:8

    Topics: Animals; Collagen; Cornea; Corneal Stroma; Diabetes Mellitus, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Microscopy, Electron; Proteoglycans; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tissue Distribution; Tyrphostins

2009
Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment.
    Cancer letters, 2009, Nov-18, Volume: 285, Issue:1

    Topics: Androgens; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Benzothiazoles; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Dose-Response Relationship, Drug; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gemcitabine; Humans; Male; Prostatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Receptor, ErbB-2; Time Factors; Tyrphostins

2009
KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin.
    Development (Cambridge, England), 2009, Volume: 136, Issue:13

    Topics: Amphiregulin; Animals; beta Catenin; Cadherins; Cell Differentiation; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Glycoproteins; Hair Follicle; Hedgehog Proteins; Heparin-binding EGF-like Growth Factor; Hyaluronan Receptors; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Morphogenesis; Oncogene Proteins; Quinazolines; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Skin; Syndecan-1; Tissue Culture Techniques; Trans-Activators; Tyrphostins; Vibrissae; Wnt Proteins; Zinc Finger Protein GLI1

2009
Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway.
    Oncogene, 2009, Jul-30, Volume: 28, Issue:30

    Topics: Cell Line, Tumor; Cell Movement; ErbB Receptors; Fibroblast Growth Factor 2; Humans; Kininogen, High-Molecular-Weight; Male; Neoplasm Invasiveness; Prostatic Neoplasms; Protein Structure, Tertiary; Quinazolines; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Tyrphostins

2009
[Effects of theaflavins on the signal transduction pathway of epidermal growth factor receptor in airway mucous hypersecretion].
    Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases, 2009, Volume: 32, Issue:1

    Topics: Biflavonoids; Catechin; Cell Line, Tumor; ErbB Receptors; Humans; JNK Mitogen-Activated Protein Kinases; Mucin 5AC; Phosphorylation; Quinazolines; Respiratory Mucosa; Signal Transduction; Tyrphostins

2009
ERK phosphorylation in intact, adult brain by alpha(2)-adrenergic transactivation of EGF receptors.
    Neurochemistry international, 2009, Volume: 55, Issue:7

    Topics: Animals; Anticoagulants; Astrocytes; Blotting, Western; Brain Chemistry; Dexmedetomidine; Dipeptides; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Heparin; Hypnotics and Sedatives; Immunoprecipitation; Male; Mice; Phosphorylation; Protease Inhibitors; Quinazolines; Receptors, Adrenergic, alpha-2; Transcriptional Activation; Tyrphostins

2009
Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.
    Journal of periodontal research, 2009, Volume: 44, Issue:1

    Topics: Cells, Cultured; Collagen Type I; Culture Media; Enzyme Inhibitors; Enzyme Precursors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gelatinases; Gingiva; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Matrix Metalloproteinase 14; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptors, Cell Surface; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Tyrphostins

2009
Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:3

    Topics: Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; ErbB Receptors; fas Receptor; Fas-Associated Death Domain Protein; Hepatocytes; Liver; Liver Failure; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Nitrobenzenes; Quinazolines; Sulfonamides; Tyrphostins; Up-Regulation

2009
MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Jul-21, Volume: 106, Issue:29

    Topics: Adult; Aged; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; ErbB Receptors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MicroRNAs; Middle Aged; Mutation; Quinazolines; RNA, Antisense; Signal Transduction; Smoking; Tyrphostins

2009
EGFR-PLCgamma1 signaling mediates high glucose-induced PKCbeta1-Akt activation and collagen I upregulation in mesangial cells.
    American journal of physiology. Renal physiology, 2009, Volume: 297, Issue:3

    Topics: Animals; Blood Glucose; Cells, Cultured; Collagen Type I; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Estrenes; Female; Male; Mesangial Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Proto-Oncogene Proteins c-akt; Pyrrolidinones; Quinazolines; Rats; Rats, Sprague-Dawley; RNA Interference; Tyrphostins; Up-Regulation

2009
Epidermal growth factor receptor inhibitors promote CNS axon growth through off-target effects on glia.
    Neurobiology of disease, 2009, Volume: 36, Issue:1

    Topics: Analysis of Variance; Animals; Axons; Carbazoles; Cell Proliferation; Cells, Cultured; Central Nervous System; Culture Media, Conditioned; Cyclic AMP; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Ganglia, Spinal; Glial Fibrillary Acidic Protein; Indole Alkaloids; Myelin Sheath; Nerve Crush; Nerve Growth Factors; Neuroglia; Neurons; Quinazolines; Rats; RNA, Small Interfering; S100 Proteins; Transfection; Tyrphostins

2009
[Analysis of tyrphostin AG1478 effect on behavior of internalized EGF receptor at different stages of endocytosis].
    Tsitologiia, 2009, Volume: 51, Issue:6

    Topics: Cell Line, Tumor; Endocytosis; Enzyme Inhibitors; ErbB Receptors; Humans; Protein Tyrosine Phosphatases; Quinazolines; Tyrphostins

2009
Naegleria fowleri induces MUC5AC and pro-inflammatory cytokines in human epithelial cells via ROS production and EGFR activation.
    Microbiology (Reading, England), 2009, Volume: 155, Issue:Pt 11

    Topics: Animals; Cell Line; Central Nervous System Protozoal Infections; Dimethyl Sulfoxide; Epithelial Cells; ErbB Receptors; Humans; Immunity, Innate; Interleukin-1beta; Interleukin-8; Male; Mice; Mice, Inbred BALB C; Mucin 5AC; Naegleria fowleri; Neutrophils; Quinazolines; Reactive Oxygen Species; Trophozoites; Tyrphostins

2009
Effects of cigarette smoking on mucin production in human middle ear epithelial cells.
    International journal of pediatric otorhinolaryngology, 2009, Volume: 73, Issue:10

    Topics: Analysis of Variance; Blotting, Western; Cells, Cultured; Ear, Middle; Epithelial Cells; ErbB Receptors; Humans; Mucins; Otitis Media; Quinazolines; Reference Values; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensitivity and Specificity; Smoke; Smoking; Tumor Necrosis Factor-alpha; Tyrphostins; Up-Regulation

2009
Effect of epidermal growth factor receptor inhibitor alone and in combination with cisplatin on growth of vulvar cancer cells.
    Annals of the New York Academy of Sciences, 2009, Volume: 1171

    Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Female; Humans; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Tyrphostins; Vulvar Neoplasms

2009
Cell motility and spreading are suppressed by HOXA4 in ovarian cancer cells: possible involvement of beta1 integrin.
    Molecular cancer research : MCR, 2009, Volume: 7, Issue:9

    Topics: Analysis of Variance; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Shape; Enzyme Inhibitors; Female; Fibronectins; Gene Knockdown Techniques; Homeodomain Proteins; Humans; Immunohistochemistry; Integrin alpha5; Integrin beta1; Ovarian Neoplasms; Quinazolines; RNA, Small Interfering; Signal Transduction; Transcription Factors; Tyrphostins

2009
Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology.
    Journal of immunological methods, 2009, Oct-31, Volume: 350, Issue:1-2

    Topics: Adipose Tissue; Adult; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Flow Cytometry; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mesenchymal Stem Cells; Microspheres; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Tyrphostins

2009
Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.
    Stem cells (Dayton, Ohio), 2009, Volume: 27, Issue:11

    Topics: Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Computational Biology; Epidermal Growth Factor; Humans; Immunoassay; Least-Squares Analysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multivariate Analysis; Osteogenesis; Phosphoproteins; Phosphotransferases; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Stem Cells; Stromal Cells; Tyrphostins

2009
Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra.
    Journal of natural products, 2009, Volume: 72, Issue:10

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Cobra Cardiotoxin Proteins; Elapid Venoms; ErbB Receptors; Humans; Membrane Potential, Mitochondrial; Phosphorylation; Protein Conformation; Proto-Oncogene Proteins c-akt; Quinazolines; Tyrphostins

2009
Early weaning accelerates the differentiation of mucous neck cells in rat gastric mucosa: possible role of TGFalpha/EGFR.
    Differentiation; research in biological diversity, 2010, Volume: 79, Issue:1

    Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; ErbB Receptors; Female; Gastric Mucosa; Gene Expression Regulation, Developmental; Immunoenzyme Techniques; Mucin-6; Quinazolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor alpha; Tyrphostins; Weaning

2010
Off-target effects of epidermal growth factor receptor antagonists mediate retinal ganglion cell disinhibited axon growth.
    Brain : a journal of neurology, 2009, Volume: 132, Issue:Pt 11

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Axons; Cell Proliferation; Cells, Cultured; Culture Media, Conditioned; Cyclic AMP; ErbB Receptors; Female; Humans; Mice; Nerve Growth Factors; Nerve Regeneration; Neuroglia; Optic Nerve; Quinazolines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Rats, Wistar; Receptor, trkA; Receptor, trkB; Receptor, trkC; Recombinant Fusion Proteins; Retinal Ganglion Cells; RNA, Small Interfering; Tyrphostins

2009
Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 332, Issue:1

    Topics: Angiotensin II; Animals; Aorta, Thoracic; Butadienes; Cell Culture Techniques; Cell Migration Assays; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; src-Family Kinases; Syk Kinase; Transcriptional Activation; Tyrphostins

2010
Protein kinase D stabilizes aldosterone-induced ERK1/2 MAP kinase activation in M1 renal cortical collecting duct cells to promote cell proliferation.
    The Journal of steroid biochemistry and molecular biology, 2010, Volume: 118, Issue:1-2

    Topics: Acetophenones; Active Transport, Cell Nucleus; Aldosterone; Animals; Benzopyrans; Cell Line; Cell Proliferation; Cytoplasm; Enzyme Activation; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Kidney Cortex; Kidney Tubules, Collecting; Mice; Mineralocorticoid Receptor Antagonists; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphorylation; Protein Binding; Protein Kinase C-delta; Protein Kinase Inhibitors; Quinazolines; Receptors, Mineralocorticoid; Signal Transduction; Spironolactone; TRPP Cation Channels; Tyrphostins

2010
Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.
    FEBS letters, 2009, Nov-19, Volume: 583, Issue:22

    Topics: 3T3-L1 Cells; Adipogenesis; Animals; Blotting, Western; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Mice; Mice, Knockout; Phosphorylation; Plant Extracts; Protein Kinase C-alpha; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; TRPV Cation Channels; Tyrphostins

2009
Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells.
    Journal of neuro-oncology, 2010, Volume: 97, Issue:3

    Topics: Animals; Animals, Newborn; Apoptosis; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Green Fluorescent Proteins; Humans; Mutation; Nerve Tissue Proteins; Neurons; Oxidative Stress; Quinazolines; Signal Transduction; Stem Cells; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Tyrphostins

2010
JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells.
    American journal of physiology. Gastrointestinal and liver physiology, 2010, Volume: 298, Issue:1

    Topics: Amino Acids, Cyclic; Anthracenes; Calcium; Carbachol; Cell Line; Cell Polarity; Chlorides; Cholinergic Agonists; Colon; Enzyme Inhibitors; Epithelial Cells; Flavonoids; Humans; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Phosphorylation; Potassium; Quinazolines; Thapsigargin; Tyrphostins

2010
Angiotensin-induced EGF receptor transactivation inhibits insulin signaling in C9 hepatic cells.
    Biochemical pharmacology, 2010, Mar-01, Volume: 79, Issue:5

    Topics: Angiotensin II; Animals; Cell Line; Enzyme Inhibitors; ErbB Receptors; Hepatocytes; Insulin; Insulin Resistance; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Receptor, Insulin; Serine; Signal Transduction; Threonine; Transcriptional Activation; Tyrphostins; Vasoconstrictor Agents

2010
The EGF receptor-sox2-EGF receptor feedback loop positively regulates the self-renewal of neural precursor cells.
    Stem cells (Dayton, Ohio), 2010, Volume: 28, Issue:2

    Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chromatin Immunoprecipitation; Chromones; Enzyme Inhibitors; ErbB Receptors; Immunohistochemistry; In Vitro Techniques; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Neurons; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; RNA Interference; SOXB1 Transcription Factors; Tyrphostins

2010
Differential contribution of direct-developing and stem cell-derived melanocytes to the zebrafish larval pigment pattern.
    Developmental biology, 2010, Jan-15, Volume: 337, Issue:2

    Topics: Animals; Cell Differentiation; Larva; Melanins; Melanocytes; Mutation; Phenylthiourea; Pigmentation; Quinazolines; Receptor Protein-Tyrosine Kinases; Regeneration; Stem Cells; Time Factors; Tyrphostins; Zebrafish

2010
Cell-type-specific roles of IGF-1R and EGFR in mediating Zn2+-induced ERK1/2 and PKB phosphorylation.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2010, Volume: 15, Issue:3

    Topics: Animals; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; ErbB Receptors; Humans; Insulin Receptor Substrate Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Myocytes, Smooth Muscle; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, IGF Type 1; Receptor, Insulin; Tyrphostins; Up-Regulation; Zinc

2010
Termination of tyrphostin AG1478 application results in different recovery of EGF receptor tyrosine residues 1045 and 1173 phosphorylation in A431 cells.
    Cell biology international, 2009, Dec-16, Volume: 34, Issue:1

    Topics: Cell Line, Tumor; Endocytosis; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proto-Oncogene Proteins c-cbl; Quinazolines; Tyrosine; Tyrphostins; Ubiquitination

2009
Nanoscale imaging of epidermal growth factor receptor clustering: effects of inhibitors.
    The Journal of biological chemistry, 2010, Jan-29, Volume: 285, Issue:5

    Topics: Cell Membrane; Dimerization; Enzyme Inhibitors; ErbB Receptors; HeLa Cells; Humans; Membrane Microdomains; Microscopy; Microscopy, Confocal; Nanotechnology; Prognosis; Protein Structure, Tertiary; Quinazolines; Tyrphostins

2010
Effect of urotensin II on PC12 rat pheochromocytoma cells.
    Journal of neuroendocrinology, 2010, Volume: 22, Issue:2

    Topics: Amino Acid Sequence; Animals; Cell Proliferation; Chromaffin Cells; DNA; Dopamine; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Quinazolines; Rats; Receptors, G-Protein-Coupled; RNA, Messenger; Tyrosine 3-Monooxygenase; Tyrphostins; Urotensins

2010
Contribution of epidermal growth factor receptor transactivation in angiotensin II-induced enhanced expression of Gi protein and proliferation in A10 vascular smooth muscle cells.
    Canadian journal of physiology and pharmacology, 2009, Volume: 87, Issue:12

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Blotting, Western; Cell Line; Cell Proliferation; ErbB Receptors; GTP-Binding Protein alpha Subunits, Gi-Go; Imidazoles; Losartan; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pyridines; Quinazolines; Rats; Receptors, Angiotensin; Transcriptional Activation; Tyrphostins

2009
Role of epidermal growth factor receptor in ovine fetal pulmonary vascular remodeling following exposure to high altitude long-term hypoxia.
    High altitude medicine & biology, 2009,Winter, Volume: 10, Issue:4

    Topics: Actins; Altitude; Animals; Cell Proliferation; Cells, Cultured; ErbB Receptors; Female; Fetal Hypoxia; Muscle, Smooth, Vascular; Pregnancy; Proliferating Cell Nuclear Antigen; Pulmonary Artery; Quinazolines; Sheep, Domestic; Tyrphostins

2009
New platform for controlled and sustained delivery of the EGF receptor tyrosine kinase inhibitor AG1478 using poly(lactic-co-glycolic acid) microspheres.
    Journal of microencapsulation, 2010, Volume: 27, Issue:3

    Topics: Animals; Carcinoma; Cell Line; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Humans; Lactic Acid; Microspheres; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protein-Tyrosine Kinases; Quinazolines; Rats; Tyrphostins

2010
P2Y2 nucleotide receptors mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ErbB3 in human salivary gland cells.
    The Journal of biological chemistry, 2010, Mar-05, Volume: 285, Issue:10

    Topics: ADAM Proteins; ADAM10 Protein; ADAM17 Protein; Amyloid Precursor Protein Secretases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Membrane Proteins; Metalloproteases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuregulin-1; Phosphorylation; Protein Multimerization; Purinergic P2 Receptor Agonists; Quinazolines; Receptor, ErbB-3; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; RNA, Small Interfering; Salivary Glands; Signal Transduction; Tyrphostins

2010
Epidermal growth factor receptor as a target for anti-proliferative treatment of proliferative cholangitis in hepatolithiasis.
    The Journal of surgical research, 2011, Volume: 166, Issue:1

    Topics: Animals; Bromodeoxyuridine; Cell Division; Cholangitis; Collagen Type I; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; fas Receptor; Fibrosis; Gene Expression; In Situ Nick-End Labeling; Ki-67 Antigen; Lithiasis; Male; Mucin 5AC; Quinazolines; Rats; Rats, Sprague-Dawley; Recurrence; Tyrphostins

2011
Epidermal growth factor can be used in lieu of follicle-stimulating hormone for nuclear maturation of porcine oocytes in vitro.
    Theriogenology, 2010, Volume: 73, Issue:8

    Topics: Animals; Cell Nucleus; Cells, Cultured; Drug Interactions; Embryo Culture Techniques; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Growth Factor; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Oocytes; Oogenesis; Protein Biosynthesis; Quinazolines; Swine; Therapeutic Equivalency; Tyrphostins

2010
Insulin-induced ectodomain shedding of heparin-binding epidermal growth factor-like growth factor in adipocytes in vitro.
    Obesity (Silver Spring, Md.), 2010, Volume: 18, Issue:10

    Topics: 3T3-L1 Cells; ADAM Proteins; ADAM17 Protein; Adipocytes; Alkaline Phosphatase; Animals; Cell Differentiation; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Insulin; Intercellular Signaling Peptides and Proteins; Mice; Quinazolines; Recombinant Proteins; Tyrphostins

2010
Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.
    American journal of physiology. Lung cellular and molecular physiology, 2010, Volume: 298, Issue:4

    Topics: Arginase; Cell Hypoxia; Cell Proliferation; Endothelial Cells; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Lung; Microvessels; Models, Biological; Quinazolines; RNA, Messenger; RNA, Small Interfering; Time Factors; Tyrphostins; Urea

2010
The constitutive activity of epidermal growth factor receptor vIII leads to activation and differential trafficking of wild-type epidermal growth factor receptor and erbB2.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2010, Volume: 58, Issue:6

    Topics: Cell Line, Tumor; Dimerization; DNA Primers; ErbB Receptors; Female; Humans; Immunoblotting; Microscopy, Confocal; Mutation; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Polymerase Chain Reaction; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; RNA, Messenger; Tyrphostins

2010
[Effect of epidermal growth factor receptor on airway remodeling in asthmatic mice and its mechanism].
    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2010, Volume: 12, Issue:2

    Topics: Airway Remodeling; Animals; Asthma; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Male; Mice; Quinazolines; Tyrphostins

2010
Inhibition of EGFR signaling augments oridonin-induced apoptosis in human laryngeal cancer cells via enhancing oxidative stress coincident with activation of both the intrinsic and extrinsic apoptotic pathways.
    Cancer letters, 2010, Aug-28, Volume: 294, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Inducing Factor; bcl-2-Associated X Protein; Carcinoma, Squamous Cell; Cell Line, Tumor; Diterpenes, Kaurane; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Fas-Associated Death Domain Protein; Humans; Laryngeal Neoplasms; Membrane Potential, Mitochondrial; Oxidative Stress; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Reactive Oxygen Species; Signal Transduction; Sirtuin 1; Tyrphostins

2010
EGF receptor activation during allergic sensitization affects IL-6-induced T-cell influx to airways in a rat model of asthma.
    European journal of immunology, 2010, Volume: 40, Issue:6

    Topics: Allergens; Animals; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Separation; Chemotaxis, Leukocyte; Cytokines; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Interleukin-6; Lung; Ovalbumin; Quinazolines; Rats; Rats, Inbred BN; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Tyrphostins

2010
Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo.
    Neurochemistry international, 2010, Volume: 57, Issue:4

    Topics: Ammonia; Animals; Astrocytes; Blotting, Western; Brain; Cell Membrane; Cells, Cultured; Dipeptides; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Genes, src; Hyperammonemia; Isoenzymes; Mice; Protease Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Tyrphostins; Urease

2010
Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors.
    Neurochemistry international, 2010, Volume: 57, Issue:4

    Topics: Animals; Astrocytes; Blotting, Western; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; ErbB Receptors; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protease Inhibitors; Quinazolines; Receptor, Serotonin, 5-HT2B; Receptor, Serotonin, 5-HT2C; RNA, Small Interfering; Serotonin; Substrate Specificity; Transcriptional Activation; Tyrphostins

2010
Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.
    Nature medicine, 2010, Volume: 16, Issue:6

    Topics: Animals; Cell Line, Tumor; Dependovirus; ErbB Receptors; Female; Gefitinib; Gene Expression; Genetic Therapy; Genetic Vectors; Head and Neck Neoplasms; Isoantigens; Mice; Mice, Nude; Neoplasms, Experimental; Quinazolines; Receptors, Virus; Transduction, Genetic; Tyrphostins

2010
The antimicrobial peptide LL37 induces the migration of human pulp cells: a possible adjunct for regenerative endodontics.
    Journal of endodontics, 2010, Volume: 36, Issue:6

    Topics: Adenosine Triphosphate; Anthracenes; Antimicrobial Cationic Peptides; Calcium-Calmodulin-Dependent Protein Kinases; Cathelicidins; Cell Movement; Cells, Cultured; Dental Pulp; Endodontics; Enzyme Inhibitors; ErbB Receptors; Flavonoids; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Phosphorylation; Protein Tyrosine Phosphatases; Purinergic P2 Receptor Agonists; Quinazolines; Receptors, Cell Surface; Receptors, Purinergic P2X; Regenerative Medicine; Tissue Engineering; Tyrphostins

2010
Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication.
    Journal of virology, 2010, Volume: 84, Issue:15

    Topics: Animals; Cell Line; Chlorocebus aethiops; Cricetinae; Enterovirus B, Human; Enzyme Inhibitors; Golgi Apparatus; Guanine Nucleotide Exchange Factors; Humans; Pyridines; Quinazolines; Quinolines; Tyrphostins; Virus Replication

2010
Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling.
    Developmental biology, 2010, Aug-15, Volume: 344, Issue:2

    Topics: Animals; Epidermal Growth Factor; Epidermis; Epiregulin; ErbB Receptors; Fatty Acid Transport Proteins; Keratinocytes; Mice; Mice, Mutant Strains; Mice, Transgenic; Mutation; Phenotype; Quinazolines; Signal Transduction; Skin; Skin Diseases; STAT3 Transcription Factor; Tyrphostins

2010
The overexpression of heparin-binding epidermal growth factor is responsible for Th17-induced airway remodeling in an experimental asthma model.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Jul-15, Volume: 185, Issue:2

    Topics: Adoptive Transfer; Airway Remodeling; Animals; Antibodies, Monoclonal; Asthma; Blotting, Western; Cytokines; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Interleukin-17; Lung; Male; Mice; Mice, Inbred C57BL; Mucus; Ovalbumin; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Helper-Inducer; Tyrphostins

2010
Epidermal growth factor receptor transactivation by the cannabinoid receptor (CB1) and transient receptor potential vanilloid 1 (TRPV1) induces differential responses in corneal epithelial cells.
    Experimental eye research, 2010, Volume: 91, Issue:3

    Topics: Benzoxazines; Blotting, Western; Capsaicin; Cell Movement; Cell Proliferation; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Epithelium, Corneal; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Humans; Interleukin-6; Interleukin-8; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Piperidines; Pyrazoles; Quinazolines; Receptor, Cannabinoid, CB1; Transcriptional Activation; TRPV Cation Channels; Tyrphostins

2010
GPR48-Induced keratinocyte proliferation occurs through HB-EGF mediated EGFR transactivation.
    FEBS letters, 2010, Sep-24, Volume: 584, Issue:18

    Topics: Animals; Bacterial Proteins; Cell Line; Cell Proliferation; Culture Media, Conditioned; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Keratinocytes; Mice; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Receptors, G-Protein-Coupled; STAT3 Transcription Factor; Transcriptional Activation; Tyrphostins

2010
EGFR signaling is differentially activated in patient-derived glioblastoma stem cells.
    Journal of experimental therapeutics & oncology, 2010, Volume: 8, Issue:3

    Topics: Cell Line, Tumor; ErbB Receptors; Erlotinib Hydrochloride; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Signal Transduction; Tyrphostins

2010
Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH.
    Reproduction (Cambridge, England), 2010, Volume: 140, Issue:5

    Topics: Amphiregulin; Animals; Cyclic GMP; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Gap Junctions; Glycoproteins; Immunoblotting; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Meiosis; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Ovarian Follicle; Quinazolines; Tyrphostins

2010
Role of matrix metalloproteinase-9 dimers in cell migration: design of inhibitory peptides.
    The Journal of biological chemistry, 2010, Nov-12, Volume: 285, Issue:46

    Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Line, Tumor; Cell Movement; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; ErbB Receptors; Humans; Hyaluronan Receptors; Matrix Metalloproteinase 9; Models, Molecular; Mutation; Oligopeptides; Protein Binding; Protein Conformation; Protein Multimerization; Protein Structure, Tertiary; Quinazolines; RNA Interference; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Transfection; Tyrphostins

2010
[Effects of EGFR inhibitor AG1478 in combination with celecoxib on the growth of gastric cancer cells].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2010, Volume: 41, Issue:4

    Topics: Celecoxib; Cell Line, Tumor; Cell Proliferation; Drug Synergism; ErbB Receptors; Humans; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proliferating Cell Nuclear Antigen; Pyrazoles; Quinazolines; Stomach Neoplasms; Sulfonamides; Tyrphostins

2010
Epidermal growth factor receptor expression identifies functionally and molecularly distinct tumor-initiating cells in human glioblastoma multiforme and is required for gliomagenesis.
    Cancer research, 2010, Oct-01, Volume: 70, Issue:19

    Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; ErbB Receptors; Gene Silencing; Gene Transfer Techniques; Glioblastoma; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; Quinazolines; RNA, Messenger; Tyrphostins

2010
Effect of additional inhibition of human epidermal growth factor receptor 2 with the bispecific tyrosine kinase inhibitor AEE788 on the resistance to specific EGFR inhibition in glioma cells.
    International journal of molecular medicine, 2010, Volume: 26, Issue:5

    Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Glioblastoma; Humans; Protein Kinase Inhibitors; Purines; Quinazolines; Receptor, ErbB-2; Tyrphostins

2010
The prostaglandin E2 receptor, EP2, stimulates keratinocyte proliferation in mouse skin by G protein-dependent and {beta}-arrestin1-dependent signaling pathways.
    The Journal of biological chemistry, 2010, Dec-17, Volume: 285, Issue:51

    Topics: Alprostadil; Animals; Arrestins; beta-Arrestins; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Gefitinib; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; GTP-Binding Proteins; Keratinocytes; Mice; Mitogen-Activated Protein Kinase 3; Multiprotein Complexes; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Prostaglandin E, EP2 Subtype; Signal Transduction; Skin; src-Family Kinases; STAT3 Transcription Factor; Tyrphostins

2010
Downregulated ABCG2 enhances sensitivity to topoisomerase I inhibitor in epidermal growth factor receptor tyrosine kinase inhibitor-resistant non-small cell lung cancer.
    Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2010, Volume: 5, Issue:11

    Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzimidazoles; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; DNA Topoisomerases, Type I; DNA, Neoplasm; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Genotype; Humans; Lung Neoplasms; Mutation; Neoplasm Proteins; Polymerase Chain Reaction; Protein Tyrosine Phosphatases; Quinazolines; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Tyrphostins

2010
α1-Adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor.
    British journal of pharmacology, 2010, Volume: 161, Issue:6

    Topics: Animals; Aorta, Thoracic; ErbB Receptors; Male; Quinazolines; Random Allocation; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Transcriptional Activation; Tyrphostins; Vasoconstriction

2010
Demonstration of angiotensin II-induced Ras activation in the trans-Golgi network and endoplasmic reticulum using bioluminescence resonance energy transfer-based biosensors.
    The Journal of biological chemistry, 2011, Feb-18, Volume: 286, Issue:7

    Topics: Angiotensin II; Arrestins; beta-Arrestins; Biosensing Techniques; Endoplasmic Reticulum; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; HEK293 Cells; Humans; Luminescent Measurements; Oncogene Protein p21(ras); Quinazolines; Receptor, Angiotensin, Type 1; Signal Transduction; trans-Golgi Network; Tyrphostins

2011
Mechanisms of myogenic tone of coronary arteriole: Role of down stream signaling of the EGFR tyrosine kinase.
    Microvascular research, 2011, Volume: 81, Issue:1

    Topics: Animals; Arterioles; Cells, Cultured; Coronary Vessels; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; Janus Kinases; Mice; Mice, Inbred C57BL; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Nitroprusside; Phosphorylation; Potassium Chloride; Pressure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Son of Sevenless Proteins; STAT Transcription Factors; STAT3 Transcription Factor; Tyrphostins; Vasoconstriction; Vasodilation

2011
Epidermal growth factor treatment switches δ-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism.
    Molecular pharmacology, 2011, Volume: 79, Issue:2

    Topics: Blotting, Western; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Microfluidics; Microscopy, Confocal; Phosphorylation; Quinazolines; Receptor, IGF Type 1; Receptors, Opioid, delta; Transcriptional Activation; Tyrphostins

2011
EGF-dependent induction of BCL-xL and p21CIP1/WAF1 is highly variable in HNSCC cells--implications for EGFR-targeted therapies.
    Anticancer research, 2010, Volume: 30, Issue:11

    Topics: bcl-X Protein; Blotting, Western; Carcinoma, Squamous Cell; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Head and Neck Neoplasms; Humans; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins

2010
The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.
    The Journal of pathology, 2011, Volume: 223, Issue:3

    Topics: Antineoplastic Agents; Bone Neoplasms; Cell Proliferation; Chordoma; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; ErbB Receptors; Humans; In Situ Hybridization, Fluorescence; Mutation; Neoplasm Proteins; Quinazolines; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Skull Base Neoplasms; Tumor Cells, Cultured; Tyrphostins

2011
Endosomal signalling of epidermal growth factor receptors contributes to EGF-stimulated cell cycle progression in primary hepatocytes.
    European journal of pharmacology, 2011, Mar-05, Volume: 654, Issue:2

    Topics: Animals; Cell Cycle; Cell Division; Endosomes; Epidermal Growth Factor; ErbB Receptors; Hepatocytes; Male; Microscopy, Confocal; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Thymidine; Tyrphostins

2011
EGFR codon 497 polymorphism - implications for receptor sensitivity to inhibitors in HNSCC cell lines.
    Anticancer research, 2011, Volume: 31, Issue:1

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cetuximab; Codon; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Head and Neck Neoplasms; Humans; Polymorphism, Genetic; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins

2011
ERK phosphorylation predicts synergism between gemcitabine and the epidermal growth factor receptor inhibitor AG1478.
    Lung cancer (Amsterdam, Netherlands), 2011, Volume: 73, Issue:3

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gemcitabine; Humans; Mutation; Nitriles; Phosphorylation; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Quinazolines; ras Proteins; RNA, Small Interfering; Tyrphostins

2011
Bile acids promote HCV replication through the EGFR/ERK pathway in replicon-harboring cells.
    Intervirology, 2011, Volume: 54, Issue:6

    Topics: Antiviral Agents; Bile Acids and Salts; Cell Cycle; Cell Line; Chenodeoxycholic Acid; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Genes, Reporter; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Interphase; Luciferases, Renilla; Promoter Regions, Genetic; Quinazolines; Transcriptional Activation; Tyrphostins; Viral Nonstructural Proteins; Virus Replication

2011
EGFR is involved in control of gastric cell proliferation through activation of MAPK and Src signalling pathways in early-weaned rats.
    Cell proliferation, 2011, Volume: 44, Issue:2

    Topics: Animals; Cell Proliferation; Cells, Cultured; Cyclin D1; Cyclin E; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Gastric Mucosa; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitosis; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Signal Transduction; src-Family Kinases; Tyrphostins

2011
Inhibiting epidermal growth factor receptor attenuates reactive astrogliosis and improves functional outcome after spinal cord injury in rats.
    Neurochemistry international, 2011, Volume: 58, Issue:7

    Topics: Animals; Astrocytes; Behavior, Animal; Blotting, Western; ErbB Receptors; Female; Gliosis; Immunohistochemistry; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Tyrphostins

2011
Epithelial growth factor receptor tyrosine kinase inhibitor prevents infiltration and cerebrospinal fluid dissemination in malignant glioma: an experimental study.
    Neurosurgery, 2011, Volume: 69, Issue:2

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Brain Neoplasms; Cadherins; Cell Line; Enzyme Inhibitors; ErbB Receptors; Glioma; Male; Neoplasms, Experimental; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins; Up-Regulation

2011
Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling.
    Biochimica et biophysica acta, 2011, Volume: 1813, Issue:6

    Topics: Blotting, Western; Cyclin-Dependent Kinase Inhibitor p27; Epidermal Growth Factor; ErbB Receptors; HEK293 Cells; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Multimerization; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptors, Somatostatin; RNA Interference; Signal Transduction; Somatostatin; Tyrphostins

2011
Expression and regulation of amphiregulin in Gsα-mutated human bone marrow stromal cells of fibrous dysplasia of mandible.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2011, Volume: 111, Issue:5

    Topics: Adolescent; Amino Acid Substitution; Amphiregulin; Arginine; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Coloring Agents; DNA Mutational Analysis; EGF Family of Proteins; Enzyme Inhibitors; ErbB Receptors; Female; Fibrous Dysplasia of Bone; Glycoproteins; GTP-Binding Protein alpha Subunits, Gs; Humans; Intercellular Signaling Peptides and Proteins; Mandibular Diseases; Mutation, Missense; Osteoblasts; Polymorphism, Restriction Fragment Length; Quinazolines; Signal Transduction; Stromal Cells; Tetrazolium Salts; Tyrphostins

2011
Small tyrosine kinase inhibitors interrupt EGFR signaling by interacting with erbB3 and erbB4 in glioblastoma cell lines.
    Experimental cell research, 2011, Jun-10, Volume: 317, Issue:10

    Topics: Blotting, Western; Cell Proliferation; Enzyme Inhibitors; ErbB Receptors; Flow Cytometry; Glioblastoma; Humans; Immunoprecipitation; Protein Kinase Inhibitors; Quinazolines; Receptor, ErbB-3; Receptor, ErbB-4; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tumor Cells, Cultured; Tyrphostins

2011
Airway epithelial epidermal growth factor receptor mediates hogbarn dust-induced cytokine release but not Ca2+ response.
    American journal of respiratory cell and molecular biology, 2011, Volume: 45, Issue:4

    Topics: Air Pollutants, Occupational; Animal Husbandry; Animals; Antibodies, Neutralizing; Bronchi; Calcium; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Dust; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Interleukin-6; Interleukin-8; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Respiratory Mucosa; Swine; Tyrphostins

2011
GPCR/EGFR cross talk is conserved in gonadal and adrenal steroidogenesis but is uniquely regulated by matrix metalloproteinases 2 and 9 in the ovary.
    Molecular endocrinology (Baltimore, Md.), 2011, Volume: 25, Issue:6

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Animals; Butadienes; Cyclic AMP-Dependent Protein Kinases; Doxycycline; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Gonadotropins, Equine; Humans; Luteinizing Hormone; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Nitriles; Ovarian Follicle; Ovary; Progesterone; Quinazolines; Receptor Cross-Talk; Receptors, Corticotropin; Receptors, LH; Signal Transduction; Tyrphostins

2011
Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis.
    Molecular reproduction and development, 2011, Volume: 78, Issue:6

    Topics: Animals; Benzamides; C-Reactive Protein; Cell Adhesion Molecules; Cumulus Cells; Dioxoles; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation, Developmental; Glucuronosyltransferase; Hyaluronic Acid; Isoquinolines; Meiosis; Mice; Oocytes; Progesterone; Pyridines; Pyrroles; Quinazolines; Serum Amyloid P-Component; Signal Transduction; Smad2 Protein; Smad3 Protein; Swine; Tyrphostins

2011
Chronic mechanical stress induces mucin 5AC expression in human bronchial epithelial cells through ERK dependent pathways.
    Molecular biology reports, 2012, Volume: 39, Issue:2

    Topics: Analysis of Variance; Blotting, Western; Bronchi; Bronchoconstriction; Cells, Cultured; DNA Primers; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Flavonoids; Focal Adhesion Kinase 1; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Mucin 5AC; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Stress, Physiological; Tyrphostins

2012
Combined treatment of curcumin and small molecule inhibitors suppresses proliferation of A549 and H1299 human non-small-cell lung cancer cells.
    Phytotherapy research : PTR, 2012, Volume: 26, Issue:1

    Topics: Antineoplastic Agents; Biological Availability; Caffeic Acids; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Chromones; Curcuma; Curcumin; Drug Therapy, Combination; Enzyme Inhibitors; ErbB Receptors; Humans; Morpholines; NF-kappa B; Phenylethyl Alcohol; Phosphoinositide-3 Kinase Inhibitors; Phytotherapy; Plant Extracts; Pyrimidines; Quinazolines; Receptors, Fibroblast Growth Factor; Signal Transduction; Somatomedins; Tyrphostins

2012
Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism.
    The Journal of clinical investigation, 2011, Volume: 121, Issue:6

    Topics: Administration, Rectal; Animals; Apoptosis; Bacterial Proteins; Colitis; Dextran Sulfate; Drug Evaluation, Preclinical; Enzyme Activation; Epithelial Cells; ErbB Receptors; Hydrogels; Intestinal Mucosa; Lacticaseibacillus rhamnosus; Mice; Mice, Inbred C57BL; Microspheres; Oxazolone; Permeability; Probiotics; Proto-Oncogene Proteins c-akt; Quinazolines; Recombinant Proteins; Signal Transduction; Tyrphostins

2011
Nanospheres delivering the EGFR TKI AG1478 promote optic nerve regeneration: the role of size for intraocular drug delivery.
    ACS nano, 2011, Jun-28, Volume: 5, Issue:6

    Topics: Animals; Axons; Coumarins; Drug Delivery Systems; ErbB Receptors; Female; Lactic Acid; Microscopy, Fluorescence; Microspheres; Models, Chemical; Nanospheres; Nerve Regeneration; Neurons; Optic Nerve; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Thiazoles; Tyrphostins

2011
Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferation.
    American journal of physiology. Renal physiology, 2011, Volume: 301, Issue:4

    Topics: beta-Cyclodextrins; Caveolin 1; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Enzyme Inhibitors; ErbB Receptors; Humans; MAP Kinase Kinase Kinases; Ouabain; Phosphorylation; Polycystic Kidney, Autosomal Dominant; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-fyn; Pyrimidines; Quinazolines; Signal Transduction; Sodium-Potassium-Exchanging ATPase; src-Family Kinases; Tyrphostins

2011
Cytosolic phospholipase A(2)α protects against Fas- but not LPS-induced liver injury.
    Journal of hepatology, 2011, Volume: 55, Issue:6

    Topics: Animals; Apoptosis; Caspases; Chemical and Drug Induced Liver Injury; ErbB Receptors; fas Receptor; Female; Galactosamine; Gene Expression; Group IV Phospholipases A2; Hepatocytes; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Quinazolines; Recombinant Proteins; Tyrphostins

2011
Mislocalization of large ARF-GEFs as a potential mechanism for BFA resistance in COG-deficient cells.
    Experimental cell research, 2011, Oct-01, Volume: 317, Issue:16

    Topics: Adaptor Proteins, Vesicular Transport; Animals; Brefeldin A; CHO Cells; Cricetinae; Cricetulus; Cytoplasm; Drug Resistance; Endoplasmic Reticulum; Fibroblasts; Golgi Apparatus; Golgi Matrix Proteins; Guanine Nucleotide Exchange Factors; Heat-Shock Proteins; HeLa Cells; Humans; Intracellular Membranes; Macrolides; Mannose-Binding Lectins; Membrane Proteins; Protein Transport; Proton-Translocating ATPases; Pyridines; Quinazolines; Quinolines; RNA, Small Interfering; Tyrphostins

2011
EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target.
    British journal of cancer, 2011, Jul-26, Volume: 105, Issue:3

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Carcinoma, Squamous Cell; Child; Child, Preschool; ErbB Receptors; Female; Gene Amplification; Genes, erbB-1; Humans; Mice; Mice, Nude; Middle Aged; Molecular Targeted Therapy; Mutation; Quinazolines; Tyrphostins; Up-Regulation; Uterine Cervical Neoplasms

2011
The balance between 4-hydroxynonenal and intrinsic glutathione/glutathione S-transferase A4 system may be critical for the epidermal growth factor receptor phosphorylation of human esophageal squamous cell carcinomas.
    Molecular carcinogenesis, 2011, Volume: 50, Issue:10

    Topics: Acetylcysteine; Aged; Aldehydes; Antimetabolites; Blotting, Western; Buthionine Sulfoximine; Carcinoma, Squamous Cell; Cell Line, Tumor; ErbB Receptors; Esophageal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Glutathione; Glutathione Transferase; Humans; Immunohistochemistry; Male; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Tyrphostins

2011
Cigarette smoke impairs airway epithelial barrier function and cell-cell contact recovery.
    The European respiratory journal, 2012, Volume: 39, Issue:2

    Topics: Cell Communication; Cell Division; Cells, Cultured; Electric Impedance; Electroporation; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Male; Middle Aged; Permeability; Pulmonary Disease, Chronic Obstructive; Quinazolines; Respiratory Mucosa; Smoking; Tight Junctions; Tyrphostins; Wound Healing

2012
Novel irreversible EGFR tyrosine kinase inhibitor 324674 sensitizes human colon carcinoma HT29 and SW480 cells to apoptosis by blocking the EGFR pathway.
    Biochemical and biophysical research communications, 2011, Aug-12, Volume: 411, Issue:4

    Topics: Anilides; Apoptosis; Carcinoma; Cell Proliferation; Colonic Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; HT29 Cells; Humans; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Tyrphostins

2011
A competitive co-cultivation assay for cancer drug specificity evaluation.
    Journal of biomolecular screening, 2011, Volume: 16, Issue:8

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Fluorescence; High-Throughput Screening Assays; Humans; Indoles; Kidney Neoplasms; Organ Specificity; Quinazolines; Reproducibility of Results; Sodium Azide; Sulfonamides; Tyrphostins

2011
Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway.
    British journal of pharmacology, 2012, Volume: 165, Issue:5

    Topics: Angiotensin I; Angiotensin II; Animals; Body Weight; Diabetes Mellitus; ErbB Receptors; Glucose; Hyperglycemia; Male; MAP Kinase Signaling System; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphorylation; Proto-Oncogene Mas; Proto-Oncogene Proteins; Quinazolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins

2012
MET signaling in GABAergic neuronal precursors of the medial ganglionic eminence restricts GDNF activity in cells that express GFRα1 and a new transmembrane receptor partner.
    Journal of cell science, 2011, Aug-15, Volume: 124, Issue:Pt 16

    Topics: Animals; Antibodies, Blocking; Cell Differentiation; Cell Movement; Chlorocebus aethiops; COS Cells; ErbB Receptors; GABAergic Neurons; Ganglia; Glial Cell Line-Derived Neurotrophic Factor; Glial Cell Line-Derived Neurotrophic Factor Receptors; Indoles; Median Eminence; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Piperazines; Proto-Oncogene Proteins c-met; Quinazolines; Receptor, ErbB-4; Signal Transduction; Sulfonamides; Tyrphostins

2011
ADAM-17/tumor necrosis factor-α-converting enzyme inhibits neurogenesis and promotes gliogenesis from neural stem cells.
    Stem cells (Dayton, Ohio), 2011, Volume: 29, Issue:10

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Astrocytes; Brain Injuries; Cell Differentiation; Cell Proliferation; Dipeptides; Enzyme Activation; ErbB Receptors; Female; Immunohistochemistry; Intermediate Filament Proteins; Male; Mice; Nerve Tissue Proteins; Nestin; Neural Stem Cells; Neurogenesis; Neurons; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transfection; Transforming Growth Factor alpha; Tyrphostins

2011
EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization.
    PloS one, 2011, Volume: 6, Issue:8

    Topics: Animals; Cell Membrane; Ceramides; Cholesterol; Enzyme Activation; ErbB Receptors; Humans; Hydrogen Peroxide; Ligands; Mice; Models, Biological; NIH 3T3 Cells; Oxidative Stress; Phosphorylation; Protein Binding; Protein Multimerization; Protein Structure, Tertiary; Protein Transport; Pyrazoles; Pyrimidines; Quinazolines; src-Family Kinases; Temperature; Tyrphostins

2011
Effect of heparin-binding EGF-like growth factor and amphiregulin on the MAP kinase-induced production of vascular endothelial growth factor by human granulosa cells.
    Growth factors (Chur, Switzerland), 2011, Volume: 29, Issue:6

    Topics: Amphiregulin; Blotting, Western; Butadienes; Cell Line; Cell Proliferation; EGF Family of Proteins; Enzyme-Linked Immunosorbent Assay; Female; Glycoproteins; Granulosa Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Nitriles; Quinazolines; Tyrphostins; Vascular Endothelial Growth Factors

2011
The tyrphostin AG1478 inhibits proliferation and induces death of liver tumor cells through EGF receptor-dependent and independent mechanisms.
    Biochemical pharmacology, 2011, Dec-01, Volume: 82, Issue:11

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Synergism; ErbB Receptors; Fetus; Gene Knockdown Techniques; Hepatocytes; Humans; Liver Neoplasms; Quinazolines; Tyrphostins

2011
Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells.
    Experimental lung research, 2011, Volume: 37, Issue:8

    Topics: Animals; Cell Culture Techniques; Cell Proliferation; Cell Separation; Cells, Cultured; Epidermal Growth Factor; Epigen; Epithelial Cells; ErbB Receptors; Interleukin-13; Ligands; Mice; Quinazolines; Trachea; Tyrphostins

2011
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.
    BMC cancer, 2011, Sep-06, Volume: 11

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Head and Neck Neoplasms; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Quinazolines; Signal Transduction; Sirolimus; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Tyrphostins

2011
Insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1.
    Molecules and cells, 2011, Volume: 32, Issue:4

    Topics: Animals; Cell Line; ErbB Receptors; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin-Secreting Cells; Isoquinolines; Naphthalenes; Oncogene Protein v-akt; Organophosphonates; Phosphorylation; Quinazolines; Rats; Receptor Cross-Talk; Receptors, AMPA; Tetrazoles; Tyrphostins

2011
Effect of bisphenol A on the EGFR-STAT3 pathway in MCF-7 breast cancer cells.
    Molecular medicine reports, 2012, Volume: 5, Issue:1

    Topics: Benzhydryl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Phenols; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Time Factors; Tyrphostins

2012
Lentivirus-mediated ADAM17 RNA interference inhibited interleukin-8 expression via EGFR signaling in lung epithelial cells.
    Inflammation, 2012, Volume: 35, Issue:3

    Topics: ADAM Proteins; ADAM17 Protein; Antibodies, Neutralizing; Cell Line; Epithelial Cells; ErbB Receptors; Gene Transfer Techniques; Genetic Vectors; Humans; Inflammation; Interleukin-8; Lentivirus; Lipopolysaccharides; Lung; Phosphorylation; Quinazolines; Respiratory Mucosa; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins

2012
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis.
    Nature medicine, 2011, Sep-25, Volume: 17, Issue:10

    Topics: Analysis of Variance; Animals; Blotting, Western; Bone Marrow Transplantation; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Flow Cytometry; Glomerulonephritis; Heparin-binding EGF-like Growth Factor; Humans; In Situ Hybridization; Intercellular Signaling Peptides and Proteins; Kidney Glomerulus; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Phosphorylation; Podocytes; Quinazolines; Real-Time Polymerase Chain Reaction; Renal Insufficiency; Statistics, Nonparametric; Tyrphostins

2011
Inhibition of Lassa virus and Ebola virus infection in host cells treated with the kinase inhibitors genistein and tyrphostin.
    Archives of virology, 2012, Volume: 157, Issue:1

    Topics: Antiviral Agents; Cell Line; Ebolavirus; Genistein; Hemorrhagic Fever, Ebola; Humans; Lassa Fever; Lassa virus; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2012
EGF receptor inhibitors increase ErbB3 mRNA and protein levels in breast cancer cells.
    Cellular signalling, 2012, Volume: 24, Issue:1

    Topics: Breast Neoplasms; Butadienes; Cell Line, Tumor; Chromones; ErbB Receptors; Erlotinib Hydrochloride; Female; Gefitinib; Gene Expression; Gene Expression Profiling; Humans; Imidazoles; MAP Kinase Kinase 1; Morpholines; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyridines; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; RNA, Messenger; Signal Transduction; Tyrphostins; Up-Regulation

2012
EGFR is dispensable for c-Met-mediated proliferation and survival activities in mouse adult liver oval cells.
    Cellular signalling, 2012, Volume: 24, Issue:2

    Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Deletion; Gene Expression; Heparin-binding EGF-like Growth Factor; Hepatocytes; Intercellular Signaling Peptides and Proteins; Liver; Mice; Mice, Knockout; Phosphorylation; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Quinazolines; Signal Transduction; Stem Cells; Transforming Growth Factor alpha; Tyrphostins

2012
Effect of epidermal growth factor on follicle-stimulating hormone-induced proliferation of granulosa cells from chicken prehierarchical follicles.
    Journal of Zhejiang University. Science. B, 2011, Volume: 12, Issue:11

    Topics: Animals; Apoptosis; Cell Growth Processes; Chickens; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Granulosa Cells; In Situ Nick-End Labeling; Ovarian Follicle; Proliferating Cell Nuclear Antigen; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tyrphostins

2011
Constitutive coupling of a naturally occurring human alpha1a-adrenergic receptor genetic variant to EGFR transactivation pathway.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Dec-06, Volume: 108, Issue:49

    Topics: ADAM Proteins; ADAM12 Protein; Amino Acid Substitution; Animals; Arrestins; beta-Arrestins; Blotting, Western; Cell Line; Cell Proliferation; Dipeptides; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Matrix Metalloproteinase 7; Matrix Metalloproteinase Inhibitors; Membrane Proteins; Microscopy, Confocal; Mutation; Phosphorylation; Quinazolines; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Transcriptional Activation; Tyrphostins

2011
Versican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapy.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Animals; Anthracenes; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Survival; Docetaxel; Doxorubicin; Epirubicin; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Green Fluorescent Proteins; Humans; Mice; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sphingosine; Taxoids; Tyrphostins; Versicans

2011
Ovarian expression and regulation of the stromelysins during the periovulatory period in the human and the rat.
    Biology of reproduction, 2012, Volume: 86, Issue:3

    Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Female; Granulosa Cells; Hormone Antagonists; Humans; Matrix Metalloproteinase 10; Matrix Metalloproteinase 11; Matrix Metalloproteinase 3; Mifepristone; Ovary; Ovulation; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Species Specificity; Theca Cells; Tyrphostins

2012
p120-catenin modulates airway epithelial cell migration induced by cigarette smoke.
    Biochemical and biophysical research communications, 2012, Jan-06, Volume: 417, Issue:1

    Topics: Adherens Junctions; Catenins; Cell Movement; Cells, Cultured; Delta Catenin; Epithelial Cells; ErbB Receptors; Gene Knockdown Techniques; Humans; Nicotiana; Protein Kinase Inhibitors; Quinazolines; Respiratory Mucosa; Smoke; Smoking; src-Family Kinases; Tyrphostins

2012
What can and cannot be done using a microarray analysis? Treatment stratification and clinical applications in oncology.
    Biological & pharmaceutical bulletin, 2011, Volume: 34, Issue:12

    Topics: Antineoplastic Agents; Butadienes; Early Growth Response Protein 1; ErbB Receptors; Gene Expression Profiling; Genes, Neoplasm; HEK293 Cells; Humans; Microarray Analysis; Molecular Targeted Therapy; Mutation; Neoplasms; Nitriles; Protein Kinase Inhibitors; Quinazolines; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Tyrphostins

2011
Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer.
    Oncogene, 2012, Sep-13, Volume: 31, Issue:37

    Topics: Benzamides; Biomarkers, Tumor; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Cyclohexanones; Disease-Free Survival; ErbB Receptors; Female; Humans; Interleukin-6; Neoplasms, Glandular and Epithelial; NF-kappa B; Ovarian Neoplasms; Plasminogen Activator Inhibitor 1; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Tumor Microenvironment; Tyrphostins

2012
Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy.
    Nature neuroscience, 2011, Dec-11, Volume: 15, Issue:2

    Topics: Action Potentials; Animals; Biophysics; Caveolin 1; Cell Line, Transformed; Disease Models, Animal; Down-Regulation; Electric Stimulation; Epilepsy; ErbB Receptors; Female; Hippocampus; Humans; Immunoprecipitation; In Vitro Techniques; Kv1.1 Potassium Channel; Male; Mice; Mice, Transgenic; Neuregulin-1; Neurons; Parvalbumins; Patch-Clamp Techniques; Pentylenetetrazole; Peptides; Pilocarpine; Potassium Channel Blockers; Quinazolines; Receptor, ErbB-2; Receptor, ErbB-4; Signal Transduction; Tyrphostins

2011
EGFR inhibitor enhances cisplatin sensitivity of human glioma cells.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2011, Volume: 31, Issue:6

    Topics: Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Glioma; Humans; Protein Tyrosine Phosphatases; Quinazolines; Tyrphostins

2011
Heparin-binding epidermal growth factor-like growth factor is a potent regulator of invasion activity in oral squamous cell carcinoma.
    Oncology reports, 2012, Volume: 27, Issue:4

    Topics: ADAM Proteins; ADAM17 Protein; Autocrine Communication; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Hydroxamic Acids; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Protease Inhibitors; Protein Kinase Inhibitors; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Time Factors; Tongue Neoplasms; Tyrphostins

2012
EGFR signaling is required for regenerative proliferation in the cochlea: conservation in birds and mammals.
    Developmental biology, 2012, Mar-01, Volume: 363, Issue:1

    Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Chromones; Cochlea; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Gene Expression Profiling; Green Fluorescent Proteins; Hair Cells, Auditory; Labyrinth Supporting Cells; Mice; Mice, 129 Strain; Mice, Knockout; Mice, Transgenic; Microscopy, Fluorescence; Morpholines; Organ Culture Techniques; Organ of Corti; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Nerve Growth Factor; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins

2012
Dietary calcium supplementation enhances efficacy but also toxicity of EGFR inhibitor therapy for colon cancer.
    Cancer biology & therapy, 2012, Feb-01, Volume: 13, Issue:3

    Topics: Animals; Antineoplastic Agents; Azoxymethane; Calcium; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dietary Supplements; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Humans; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Quinazolines; Random Allocation; Tumor Burden; Tyrphostins

2012
ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response.
    Biochemical and biophysical research communications, 2012, Feb-03, Volume: 418, Issue:1

    Topics: Animals; Cell Nucleus; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Doxorubicin; ErbB Receptors; Heart Ventricles; Mice; Myocytes, Cardiac; Protein Kinase Inhibitors; Quinazolines; Rats; Receptor, ErbB-4; Tumor Suppressor Protein p53; Tyrphostins

2012
Angiotensin AT1 receptor blockers suppress oxidized low-density lipoprotein-derived formation of foam cells.
    European journal of pharmacology, 2012, Mar-15, Volume: 679, Issue:1-3

    Topics: Acetyl-CoA C-Acetyltransferase; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; Biphenyl Compounds; Cells, Cultured; Cholesterol Esters; Enzyme Inhibitors; ErbB Receptors; Foam Cells; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Lipoproteins, LDL; Losartan; Macrophages; Quinazolines; Tetrazoles; Triglycerides; Tyrphostins

2012
Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway.
    The Journal of allergy and clinical immunology, 2012, Volume: 129, Issue:5

    Topics: Acetylcysteine; ADAM Proteins; ADAM17 Protein; Adult; Antigens, CD34; Asthma; Blood Cells; Cell Proliferation; Cell Transformation, Neoplastic; Cells, Cultured; Collagen Type I; ErbB Receptors; Female; Fibroblasts; Follow-Up Studies; Gefitinib; Humans; Hydrogen Peroxide; Leukocyte Common Antigens; Male; Middle Aged; Oxidative Stress; Pulmonary Disease, Chronic Obstructive; Quinazolines; Respiratory Function Tests; Signal Transduction; Stem Cells; Tyrphostins

2012
Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.
    ChemMedChem, 2012, Volume: 7, Issue:4

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line; Cetuximab; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Multiple; ErbB Receptors; Erlotinib Hydrochloride; Gefitinib; Humans; Imatinib Mesylate; Morpholines; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Quinazolines; Signal Transduction; Tyrphostins

2012
Epidermal growth factor upregulates endometrial CYR61 expression via activation of the JAK2/STAT3 pathway.
    Reproduction, fertility, and development, 2012, Volume: 24, Issue:3

    Topics: Antineoplastic Agents; Cells, Cultured; Cysteine-Rich Protein 61; Drug Evaluation, Preclinical; Endometrium; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Humans; Janus Kinase 2; MAP Kinase Signaling System; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Up-Regulation

2012
Simultaneous inhibition of EGFR and PI3K enhances radiosensitivity in human breast cancer.
    International journal of radiation oncology, biology, physics, 2012, Jul-01, Volume: 83, Issue:3

    Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chromones; ErbB Receptors; Female; G1 Phase; Humans; Mice; Mice, Nude; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Radiation Tolerance; Radiation-Sensitizing Agents; Random Allocation; Resting Phase, Cell Cycle; Tyrphostins

2012
Neutrophil gelatinase-associated lipocalin (NGAL) expression is dependent on the tumor-associated sigma-2 receptor S2RPgrmc1.
    The Journal of biological chemistry, 2012, Apr-27, Volume: 287, Issue:18

    Topics: Acetylation; Acute-Phase Proteins; Animals; Cell Line, Tumor; Cell Membrane; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Lipocalin-2; Lipocalins; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Nude; Models, Biological; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Phosphorylation; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Quinazolines; Receptors, Progesterone; Transcription Factor RelA; Transcription, Genetic; Transplantation, Heterologous; Tyrphostins

2012
Regulated intramembrane cleavage of the EGF receptor.
    Traffic (Copenhagen, Denmark), 2012, Volume: 13, Issue:8

    Topics: Amyloid Precursor Protein Secretases; Calpain; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Glycoproteins; HEK293 Cells; Humans; Ionomycin; Proteolysis; Quinazolines; Serine Endopeptidases; Serine Proteinase Inhibitors; Tyrphostins

2012
Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells.
    Biochimica et biophysica acta, 2012, Volume: 1823, Issue:6

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Binding Sites; Butadienes; Cell Line, Tumor; Claudins; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protease Inhibitors; Protein Binding; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transcription Factor AP-1; Tyrphostins

2012
Autocrine effect of EGFR ligands on the pro-inflammatory response induced by PM(2.5) exposure in human bronchial epithelial cells.
    Archives of toxicology, 2012, Volume: 86, Issue:10

    Topics: ADAM Proteins; ADAM17 Protein; Airway Remodeling; Autocrine Communication; Bronchi; Cell Line; Epithelial Cells; ErbB Receptors; Gene Silencing; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Particle Size; Particulate Matter; Quinazolines; RNA, Small Interfering; Tyrphostins

2012
The EGFR tyrosine kinase inhibitor tyrphostin AG-1478 causes hypomagnesemia and cardiac dysfunction.
    Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:8

    Topics: Animals; Biomarkers; Calcium; Dinoprost; Echocardiography; Enzyme Inhibitors; ErbB Receptors; Glutathione; Male; Oxidative Stress; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; Renal Tubular Transport, Inborn Errors; Superoxides; Tyrphostins

2012
A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:1

    Topics: Animals; Blotting, Western; Cholagogues and Choleretics; Diabetes Mellitus, Type 1; Endoplasmic Reticulum Stress; ErbB Receptors; Fibrosis; Gene Expression; Heart; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Myocardium; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Streptozocin; Taurochenodeoxycholic Acid; Transcription Factor CHOP; Tyrphostins; Vasodilation

2012
Thrombin induces epidermal growth factor receptor transactivation and CCL2 expression in human osteoblasts.
    Arthritis and rheumatism, 2012, Volume: 64, Issue:10

    Topics: Acetophenones; Adult; Amino Acid Chloromethyl Ketones; Benzopyrans; Chemokine CCL2; Enzyme Inhibitors; ErbB Receptors; Humans; Middle Aged; Osteoblasts; Protein Kinase C; Pyrimidines; Quinazolines; Receptor, PAR-1; Signal Transduction; src-Family Kinases; Thrombin; Transcriptional Activation; Tyrphostins

2012
Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types.
    Neural development, 2012, Jun-08, Volume: 7

    Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Axons; Axotomy; Copper; Embryo, Nonmammalian; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Mutation; Nerve Degeneration; Nerve Regeneration; Neurons; Oligodeoxyribonucleotides, Antisense; Peripheral Nerves; Proto-Oncogene Proteins; Quinazolines; Schwann Cells; Trans-Activators; Transcription Factors; Tyrphostins; Zebrafish; Zebrafish Proteins

2012
Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis.
    Archives of biochemistry and biophysics, 2012, Sep-01, Volume: 525, Issue:1

    Topics: Animals; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mutation; Protein Kinase Inhibitors; Quinazolines; rab GTP-Binding Proteins; rab5 GTP-Binding Proteins; Tyrphostins

2012
Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.
    Toxicon : official journal of the International Society on Toxinology, 2012, Volume: 60, Issue:5

    Topics: Analysis of Variance; Blotting, Western; Cell Line, Tumor; Cell Movement; Cobra Cardiotoxin Proteins; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Metastasis; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins

2012
Inhibition of phosphoinositide 3-kinase enhances the cytotoxicity of AG1478, an epidermal growth factor receptor inhibitor, in breast cancer cells.
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Flow Cytometry; Humans; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Tyrphostins

2012
Efficacy of EGFR inhibition is modulated by model, sex, genetic background and diet: implications for preclinical cancer prevention and therapy trials.
    PloS one, 2012, Volume: 7, Issue:6

    Topics: Animals; Antineoplastic Agents; Azoxymethane; Colorectal Neoplasms; Diet; Disease Models, Animal; ErbB Receptors; Female; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Quinazolines; Sex Factors; Tyrphostins

2012
The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells.
    Folia histochemica et cytobiologica, 2012, Jul-05, Volume: 50, Issue:2

    Topics: Autocrine Communication; Cell Death; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Inhibitory Concentration 50; Paclitaxel; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Tyrphostins

2012
Indoxyl sulfate enhances angiotensin II signaling through upregulation of epidermal growth factor receptor expression in vascular smooth muscle cells.
    Life sciences, 2012, Sep-04, Volume: 91, Issue:5-6

    Topics: Acetylcysteine; Angiotensin II; Animals; Arteriosclerosis; Cells, Cultured; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Indican; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tyrphostins; Up-Regulation

2012
A novel epidermal growth factor-dependent extracellular signal-regulated MAP kinase cascade involved in sperm functionality in sheep.
    Biology of reproduction, 2012, Volume: 87, Issue:4

    Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Quinazolines; Sheep; Sperm Capacitation; Spermatozoa; Tissue Distribution; Tyrphostins

2012
IL-1beta signals through the EGF receptor and activates Egr-1 through MMP-ADAM.
    PloS one, 2012, Volume: 7, Issue:7

    Topics: ADAM Proteins; Animals; Dipeptides; Early Growth Response Protein 1; ErbB Receptors; Humans; Interleukin-1beta; Matrix Metalloproteinases; Myocytes, Smooth Muscle; Quinazolines; Rats; Signal Transduction; Tyrphostins

2012
Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury.
    Journal of neuroinflammation, 2012, Jul-23, Volume: 9

    Topics: Animals; Animals, Newborn; Cells, Cultured; Enzyme Inhibitors; ErbB Receptors; Inflammation; Male; MAP Kinase Signaling System; Microglia; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Spinal Cord Injuries; Tyrphostins

2012
EGFR and PKC are involved in the activation of ERK1/2 and p90 RSK and the subsequent proliferation of SNU-407 colon cancer cells by muscarinic acetylcholine receptors.
    Molecular and cellular biochemistry, 2012, Volume: 370, Issue:1-2

    Topics: Calcium; Carbachol; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; Maleimides; Protein Kinase C; Quinazolines; Quinolones; Receptors, Muscarinic; Ribosomal Protein S6 Kinases, 90-kDa; Tyrphostins

2012
The tyrphostin AG1478 augments oridonin-induced A431 cell apoptosis by blockage of JNK MAPK and enhancement of oxidative stress.
    Free radical research, 2012, Volume: 46, Issue:11

    Topics: Apoptosis; Cell Culture Techniques; Cell Line, Tumor; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Humans; MAP Kinase Kinase 4; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2012
FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:9

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Gene Knockdown Techniques; Humans; Kaplan-Meier Estimate; Lapatinib; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-raf; Quinazolines; RNA Interference; Signal Transduction; Tyrphostins; Xenograft Model Antitumor Assays

2012
Proteasome inhibition augments cigarette smoke-induced GM-CSF expression in trophoblast cells via the epidermal growth factor receptor.
    PloS one, 2012, Volume: 7, Issue:8

    Topics: Blotting, Western; Cell Line; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Gene Expression Regulation; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intercellular Signaling Peptides and Proteins; Leupeptins; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 3; Nicotiana; Phosphorylation; Pregnancy; Proteasome Inhibitors; Quinazolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Smoke; Trophoblasts; Tyrphostins

2012
An in vivo C. elegans model system for screening EGFR-inhibiting anti-cancer drugs.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents; Butadienes; Caenorhabditis elegans; Drug Screening Assays, Antitumor; Enzyme Inhibitors; ErbB Receptors; Humans; Models, Animal; Mutation; Neoplasms; Nitriles; Phenotype; Protein Structure, Tertiary; Quinazolines; Transgenes; Tyrphostins

2012
The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells.
    Mediators of inflammation, 2012, Volume: 2012

    Topics: Blotting, Western; Cell Line; Epithelial Cells; ErbB Receptors; HT29 Cells; Humans; Immunoprecipitation; Interleukin-8; Intestines; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Receptor, ErbB-2; Tumor Necrosis Factor-alpha; Tyrphostins

2012
Blockade of EGFR signaling promotes glioma stem-like cell invasiveness by abolishing ID3-mediated inhibition of p27(KIP1) and MMP3 expression.
    Cancer letters, 2013, Jan-28, Volume: 328, Issue:2

    Topics: Animals; Cell Line, Tumor; Cell Movement; Cyclin-Dependent Kinase Inhibitor p27; ErbB Receptors; Glioma; Humans; Inhibitor of Differentiation Proteins; Matrix Metalloproteinase 3; Mice; Neoplasm Proteins; Neoplastic Stem Cells; Quinazolines; Signal Transduction; Tyrphostins

2013
Specific protein kinase C isoforms α and βI are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation, Enzymologic; Isoenzymes; Meiosis; Mice; Oocytes; Ovarian Follicle; Phosphorylation; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger; Tyrphostins

2012
Influence of epidermal growth factor receptor inhibitor AG1478 on epithelial-mesenchymal transition in endometrial carcinoma cells.
    International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2012, Volume: 22, Issue:9

    Topics: Carcinoma; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endometrial Neoplasms; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Quinazolines; Tumor Cells, Cultured; Tyrphostins

2012
Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.
    Cell cycle (Georgetown, Tex.), 2012, Dec-01, Volume: 11, Issue:23

    Topics: Acute-Phase Proteins; Antibiotics, Antineoplastic; Benzylamines; Berberine; Biphenyl Compounds; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gene Expression; HT29 Cells; Humans; Lipocalin-2; Lipocalins; MCF-7 Cells; Nitrophenols; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Sirolimus; Sulfonamides; Tyrphostins

2012
Tumor-associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway.
    Stem cells (Dayton, Ohio), 2013, Volume: 31, Issue:2

    Topics: Animals; Antigens, Ly; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Communication; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; Imidazoles; Macrophages; Mammary Neoplasms, Animal; Membrane Proteins; Mice; Nanog Homeobox Protein; Neoplastic Stem Cells; Octamer Transcription Factor-3; Oleanolic Acid; Quinazolines; RNA, Small Interfering; Signal Transduction; SOXB1 Transcription Factors; STAT3 Transcription Factor; Tyrphostins

2013
Migration of retinal pigment epithelial cells is EGFR/PI3K/AKT dependent.
    Frontiers in bioscience (Scholar edition), 2013, 01-01, Volume: 5, Issue:2

    Topics: Cell Growth Processes; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Retinal Pigment Epithelium; Retinaldehyde; Signal Transduction; Tyrphostins

2013
ERK1/2 activation mediated by the nutlin‑3‑induced mitochondrial translocation of p53.
    International journal of oncology, 2013, Volume: 42, Issue:3

    Topics: Antioxidants; Apoptosis; Benzothiazoles; Butadienes; Cell Line, Tumor; Cyclic N-Oxides; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mitochondria; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Osteosarcoma; Phosphorylation; Piperazines; Protein Transport; Quinazolines; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Toluene; Tumor Suppressor Protein p53; Tyrphostins

2013
Evaluation of the coordinated actions of estrogen receptors with epidermal growth factor receptor and insulin-like growth factor receptor in the expression of cell surface heparan sulfate proteoglycans and cell motility in breast cancer cells.
    The FEBS journal, 2013, Volume: 280, Issue:10

    Topics: Breast Neoplasms; Cell Movement; ErbB Receptors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Female; Gene Expression Regulation; Glypicans; Humans; Insulin-Like Growth Factor I; MCF-7 Cells; Quinazolines; Receptor Cross-Talk; Signal Transduction; Syndecan-2; Syndecan-4; Tyrphostins

2013
TGF-α/HA complex promotes tympanic membrane keratinocyte migration and proliferation via ErbB1 receptor.
    Experimental cell research, 2013, Apr-01, Volume: 319, Issue:6

    Topics: Cadherins; Cell Adhesion; Cell Migration Assays; Cell Movement; Cell Proliferation; Cells, Cultured; Epithelial Cells; ErbB Receptors; Humans; Hyaluronan Receptors; Hyaluronic Acid; Interleukins; Keratinocytes; Phenotype; Quinazolines; Transforming Growth Factor alpha; Tympanic Membrane; Tyrphostins; Vitronectin

2013
Epidermal growth factor receptor tyrosine kinase inhibition up-regulates interleukin-6 in cancer cells and induces subsequent development of interstitial pneumonia.
    Oncotarget, 2013, Volume: 4, Issue:4

    Topics: Antibodies, Neutralizing; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Gefitinib; Humans; Interleukin-6; Lung Diseases, Interstitial; Neoplasms, Experimental; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins; Up-Regulation

2013
γ-Secretase inhibition promotes fibrotic effects of albumin in proximal tubular epithelial cells.
    British journal of pharmacology, 2013, Volume: 169, Issue:6

    Topics: Amyloid Precursor Protein Secretases; Animals; Benzodiazepinones; Cattle; Cell Line; Culture Media, Serum-Free; Endocytosis; Enzyme Inhibitors; ErbB Receptors; Fibronectins; Fibrosis; Humans; Kidney Tubules, Proximal; MAP Kinase Signaling System; Opossums; Proteolysis; Quinazolines; Serum Albumin, Bovine; Transforming Growth Factor beta1; Tyrphostins; Urothelium

2013
The modulation of large airway smooth muscle phenotype and effects of epidermal growth factor receptor inhibition in the repeatedly allergen-challenged rat.
    American journal of physiology. Lung cellular and molecular physiology, 2013, Jun-15, Volume: 304, Issue:12

    Topics: Airway Remodeling; Allergens; Amphiregulin; Animals; Bronchi; Bronchoalveolar Lavage Fluid; EGF Family of Proteins; ErbB Receptors; Gene Expression Regulation; Glycoproteins; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Methacholine Chloride; Muscle, Smooth; Myosin Heavy Chains; Ovalbumin; Quinazolines; Rats; Respiratory Hypersensitivity; Signal Transduction; Smooth Muscle Myosins; Tyrphostins

2013
Time-dependent regulation of neuregulin-1β/ErbB/ERK pathways in cardiac differentiation of mouse embryonic stem cells.
    Molecular and cellular biochemistry, 2013, Volume: 380, Issue:1-2

    Topics: Actins; Animals; Atrial Natriuretic Factor; Butadienes; Cell Differentiation; Cell Line; Embryoid Bodies; Embryonic Stem Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GATA4 Transcription Factor; Gene Expression Regulation, Developmental; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Mice; Myocytes, Cardiac; Myosin Light Chains; Neuregulin-1; Nitriles; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; T-Box Domain Proteins; Time Factors; Transcription Factors; Tyrphostins

2013
G protein-coupled estrogen receptor1 (GPER1) may mediate Rho-kinase (ROCK-2) up-regulation in coronary endothelial cells.
    Endocrine regulations, 2013, Volume: 47, Issue:2

    Topics: Animals; Benzodioxoles; Cell Movement; Cells, Cultured; Coronary Circulation; Dactinomycin; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Estradiol; Estrogen Antagonists; Fulvestrant; Male; Nitric Oxide; Nitriles; Phenols; Progesterone; Protein Synthesis Inhibitors; Pyrazoles; Quinazolines; Quinolines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; rho-Associated Kinases; Testosterone; Tyrphostins; Up-Regulation

2013
Epidermal growth factor receptor transactivation by intracellular prostaglandin E2-activated prostaglandin E2 receptors. Role in retinoic acid receptor-β up-regulation.
    Biochimica et biophysica acta, 2013, Volume: 1833, Issue:9

    Topics: Cell Line, Tumor; Dinoprostone; Enzyme Inhibitors; ErbB Receptors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Keratolytic Agents; Kidney Tubules, Proximal; Phosphorylation; Quinazolines; Receptors, Prostaglandin E; Receptors, Retinoic Acid; Transcriptional Activation; Tretinoin; Tyrphostins; Up-Regulation; Vascular Endothelial Growth Factor A

2013
Sustained ERK [corrected] inhibition by EGFR targeting therapies is a predictive factor for synergistic cytotoxicity with PDT as neoadjuvant therapy.
    Biochimica et biophysica acta, 2013, Volume: 1830, Issue:3

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Count; Cell Line, Tumor; Cell Survival; Cetuximab; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Molecular Targeted Therapy; Neoadjuvant Therapy; Photochemotherapy; Photosensitizing Agents; Porphyrins; Quinazolines; Signal Transduction; Tyrphostins

2013
Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines.
    Journal of cellular biochemistry, 2013, Volume: 114, Issue:10

    Topics: Blotting, Western; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Humans; Mucin-1; Pancreatic Neoplasms; Quinazolines; Rosiglitazone; Thiazolidinediones; Tyrphostins; Uterine Neoplasms

2013
TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR.
    BMC gastroenterology, 2013, May-20, Volume: 13

    Topics: Cells, Cultured; Colon; Cyclooxygenase 2; Drug Synergism; ErbB Receptors; Humans; Indoles; Lysophospholipids; Matrix Metalloproteinases; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myofibroblasts; Phosphorylation; Quinazolines; Receptors, G-Protein-Coupled; Signal Transduction; src-Family Kinases; Sulfonamides; Transcriptional Activation; Tumor Necrosis Factor-alpha; Tyrphostins; Up-Regulation

2013
Profiling epidermal growth factor receptor and heregulin receptor 3 heteromerization using receptor tyrosine kinase heteromer investigation technology.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Binding Sites; ErbB Receptors; Fluorescence Resonance Energy Transfer; GRB2 Adaptor Protein; HEK293 Cells; Humans; Kinetics; Protein Binding; Protein Interaction Domains and Motifs; Protein Multimerization; Quinazolines; Receptor, ErbB-3; Signal Transduction; Tyrphostins

2013
Co-inhibition of epidermal growth factor receptor and insulin-like growth factor receptor 1 enhances radiosensitivity in human breast cancer cells.
    BMC cancer, 2013, Jun-19, Volume: 13

    Topics: Analysis of Variance; Animals; Apoptosis; Breast Neoplasms; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; G1 Phase Cell Cycle Checkpoints; Humans; MAP Kinase Signaling System; MCF-7 Cells; Mice; Mice, Nude; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Radiation Tolerance; Receptor, IGF Type 1; Tumor Stem Cell Assay; Tyrphostins

2013
The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.
    The Journal of biological chemistry, 2013, Aug-09, Volume: 288, Issue:32

    Topics: Antineoplastic Agents; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; beta-Cyclodextrins; Cholagogues and Choleretics; Cyclic AMP; Deoxycholic Acid; Endocytosis; Endosomes; Enzyme Inhibitors; ErbB Receptors; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 5; HEK293 Cells; Humans; Membrane Microdomains; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oleanolic Acid; Phenylalanine; Protein Transport; Quinazolines; Receptors, G-Protein-Coupled; Thiophenes; Tyrphostins

2013
Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.
    Cellular signalling, 2013, Volume: 25, Issue:11

    Topics: Animals; Benzothiazoles; Connective Tissue Growth Factor; Endothelium, Vascular; ErbB Receptors; Fibroblasts; Fibrosis; Gene Expression Regulation; Isoquinolines; Mice; Mink; Myocytes, Smooth Muscle; Pyridines; Pyrroles; Quinazolines; Rats; Reactive Oxygen Species; Renal Insufficiency, Chronic; Serpin E2; Signal Transduction; Smad2 Protein; Smad3 Protein; Toluene; Transforming Growth Factor beta1; Tumor Suppressor Protein p53; Tyrphostins

2013
[Molecular mechanism of chemosensitization to paclitaxel in human melanoma cells induced by targeting the EGFR signaling pathway].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Melanoma; Morpholines; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins

2013
[EGFR-ERK signaling pathway down-regulates miRNA-145 in lung cancer cells].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:3

    Topics: Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Quinazolines; Tyrphostins

2013
RANTES expression induced by Toll-like receptor 4 ligand in rat airway smooth muscle cells.
    Journal of medical and dental sciences, 2010, Mar-01, Volume: 57, Issue:4

    Topics: Animals; Asthma; Cell Culture Techniques; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Chromones; Dipeptides; ErbB Receptors; Lipopolysaccharides; Male; Matrix Metalloproteinase Inhibitors; Morpholines; Myocytes, Smooth Muscle; Phosphoinositide-3 Kinase Inhibitors; Protein Tyrosine Phosphatases; Quinazolines; Rats, Inbred BN; Signal Transduction; Toll-Like Receptor 4; Trachea; Transcriptional Activation; Tyrphostins

2010
Heparin-binding EGF-like growth factor enhances the activity of invasion and metastasis in thyroid cancer cells.
    Oncology reports, 2013, Volume: 30, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Neutralizing; Cell Line, Tumor; Cell Proliferation; Chemotaxis; Diphtheria Toxin; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Quinazolines; Receptor, ErbB-4; RNA, Messenger; Thyroid Neoplasms; Tyrphostins

2013
In brown adipocytes, adrenergically induced β₁-/β₃-(Gs)-, α₂-(Gi)- and α₁-(Gq)-signalling to Erk1/2 activation is not mediated via EGF receptor transactivation.
    Experimental cell research, 2013, Oct-15, Volume: 319, Issue:17

    Topics: Adipocytes, Brown; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic Antagonists; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Animals; Clonidine; Dioxoles; Dose-Response Relationship, Drug; Drug Synergism; ErbB Receptors; Imidazoles; Male; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Norepinephrine; Phosphorylation; Quinazolines; Receptors, Adrenergic; Tyrphostins

2013
Oxidative DNA damage and mammary cell proliferation by alcohol-derived salsolinol.
    Chemical research in toxicology, 2013, Oct-21, Volume: 26, Issue:10

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Acetylcysteine; Cell Line; Cell Proliferation; Coordination Complexes; Deoxyguanosine; DNA Damage; ErbB Receptors; Estrogen Receptor alpha; Ethanol; Female; Humans; Hydrogen Peroxide; Iron; Isoquinolines; Mammary Glands, Human; MCF-7 Cells; Oxidative Stress; Quinazolines; Transition Elements; Tyrphostins

2013
Combination of the EGFR tyrosine kinase inhibitor AG1478 and 5-FU: no synergistic effect on EGFR phosphorylation, cell proliferation and apoptosis induction.
    Anticancer research, 2013, Volume: 33, Issue:9

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Flow Cytometry; Fluorescence Resonance Energy Transfer; Fluorouracil; Humans; Phosphorylation; Quinazolines; Tyrphostins

2013
Inhibiting signal transducer and activator of transcription-3 increases response to gemcitabine and delays progression of pancreatic cancer.
    Molecular cancer, 2013, Sep-11, Volume: 12, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Progression; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gemcitabine; Gene Knockdown Techniques; Humans; Mice; Mice, Nude; Pancreatic Neoplasms; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; RNA, Small Interfering; STAT3 Transcription Factor; Tyrphostins; Xenograft Model Antitumor Assays

2013
Hexabromocyclododecane facilitates FSH activation of ERK1/2 and AKT through epidermal growth factor receptor in rat granulosa cells.
    Archives of toxicology, 2014, Volume: 88, Issue:2

    Topics: Animals; Butadienes; Cells, Cultured; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Granulosa Cells; Hydrocarbons, Brominated; MAP Kinase Signaling System; Nitriles; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar; Receptors, LH; Toxicity Tests; Tyrphostins

2014
Pb²⁺ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells.
    Environmental toxicology, 2015, Volume: 30, Issue:3

    Topics: Cell Line, Tumor; Environmental Pollutants; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Interleukin-8; Lead; Proto-Oncogene Proteins c-jun; Quinazolines; Stomach Neoplasms; Transcription Factor AP-1; Tyrphostins; Up-Regulation

2015
Parthenolide induces superoxide anion production by stimulating EGF receptor in MDA-MB-231 breast cancer cells.
    International journal of oncology, 2013, Volume: 43, Issue:6

    Topics: Acetophenones; Acetylcysteine; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Enzyme Inhibitors; ErbB Receptors; Female; Humans; NADPH Oxidases; NF-kappa B; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Sesquiterpenes; Superoxides; Tyrphostins

2013
Spatial intensity distribution analysis (SpIDA): a new tool for receptor tyrosine kinase activation and transactivation quantification.
    Methods in cell biology, 2013, Volume: 117

    Topics: Apomorphine; Cell Line; ErbB Receptors; Fluorescent Antibody Technique; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Ligands; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Imaging; Neurons; Protein Multimerization; Quinazolines; Receptor, trkB; Receptors, Dopamine; Recombinant Fusion Proteins; Software; Transcriptional Activation; Tyrphostins

2013
Epidermal growth factor receptor signaling promotes pancreatic β-cell proliferation in response to nutrient excess in rats through mTOR and FOXM1.
    Diabetes, 2014, Volume: 63, Issue:3

    Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; ErbB Receptors; Forkhead Box Protein M1; Forkhead Transcription Factors; Gene Expression Profiling; Insulin Resistance; Insulin-Secreting Cells; Male; Quinazolines; Rats; Rats, Wistar; Signal Transduction; TOR Serine-Threonine Kinases; Tyrphostins

2014
Tissue kallikrein mediates neurite outgrowth through epidermal growth factor receptor and flotillin-2 pathway in vitro.
    Cellular signalling, 2014, Volume: 26, Issue:2

    Topics: Animals; Cells, Cultured; ErbB Receptors; Humans; Membrane Proteins; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurites; Neurons; Phosphorylation; Quinazolines; RNA Interference; RNA, Small Interfering; Signal Transduction; Tissue Kallikreins; Tyrphostins

2014
GnRH-(1-5) transactivates EGFR in Ishikawa human endometrial cells via an orphan G protein-coupled receptor.
    Molecular endocrinology (Baltimore, Md.), 2014, Volume: 28, Issue:1

    Topics: Calcium Signaling; Cell Line, Tumor; Cell Movement; Endometrial Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Gonadotropin-Releasing Hormone; Humans; Matrix Metalloproteinase Inhibitors; Oligopeptides; Oncogene Proteins; Peptide Fragments; Phenylalanine; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; Quinazolines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, LHRH; Thiophenes; Transcriptional Activation; Tyrphostins

2014
Transcriptional regulation of Δ6-desaturase by peroxisome proliferative-activated receptor δ agonist in human pancreatic cancer cells: role of MEK/ERK1/2 pathway.
    TheScientificWorldJournal, 2013, Volume: 2013

    Topics: Cell Line, Tumor; ErbB Receptors; Fatty Acid Desaturases; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Signaling System; Pancreatic Neoplasms; PPAR delta; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger; RNA, Neoplasm; Thiazoles; Tyrphostins

2013
[Effects of AG1478 on the expression of FOXM1 gene via FOXO3a in non-small cell lung cancer cells].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2013, Volume: 35, Issue:8

    Topics: Adenocarcinoma; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; ErbB Receptors; Forkhead Box Protein M1; Forkhead Box Protein O3; Forkhead Transcription Factors; Humans; Lung Neoplasms; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transfection; Tyrphostins

2013
Effect of NRG-1/ErbB signaling intervention on the differentiation of bone marrow stromal cells into sinus node-like cells.
    Journal of cardiovascular pharmacology, 2014, Volume: 63, Issue:5

    Topics: Action Potentials; Animals; Bone Marrow Cells; Cell Differentiation; ErbB Receptors; Neuregulin-1; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Sinoatrial Node; Stromal Cells; Tyrphostins

2014
Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Feb-01, Volume: 192, Issue:3

    Topics: Adolescent; Adult; Aged; Animals; Cell Line; Colitis; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Cytokines; Dextran Sulfate; ErbB Receptors; Female; Gene Expression Regulation; Humans; Immunity, Innate; Inflammation; Interferon-gamma; Interleukin-10; Lipopolysaccharides; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Middle Aged; Myeloid Cells; Neutrophils; NF-kappa B; Quinazolines; Regeneration; Signal Transduction; Spleen; Tumor Necrosis Factor-alpha; Tyrphostins; Young Adult

2014
Screening and discovery of nitro-benzoxadiazole compounds activating epidermal growth factor receptor (EGFR) in cancer cells.
    Scientific reports, 2014, Feb-05, Volume: 4

    Topics: Cell Line, Tumor; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Humans; Neoplasms; Nitro Compounds; Oxadiazoles; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins

2014
Anti-EGFR therapeutic efficacy correlates directly with inhibition of STAT3 activity.
    Cancer biology & therapy, 2014, Volume: 15, Issue:5

    Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Cell Line, Tumor; Cetuximab; Colonic Neoplasms; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Heterografts; Humans; Mice, Inbred BALB C; Quinazolines; Receptor-Like Protein Tyrosine Phosphatases, Class 2; STAT3 Transcription Factor; Tyrphostins

2014
4-Hydroxynonenal impairs transforming growth factor-β1-induced elastin synthesis via epidermal growth factor receptor activation in human and murine fibroblasts.
    Free radical biology & medicine, 2014, Volume: 71

    Topics: Adult; Aging; Aldehydes; Animals; Aorta; Cell Line, Transformed; Elastin; ErbB Receptors; Fibroblasts; Flavonoids; Gene Expression Regulation; Homeodomain Proteins; Humans; Lipid Peroxidation; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Primary Cell Culture; Protein Transport; Quinazolines; Repressor Proteins; Signal Transduction; Smad2 Protein; Smad3 Protein; Transforming Growth Factor beta1; Tyrphostins

2014
β-Adrenergic receptor-mediated transactivation of epidermal growth factor receptor decreases cardiomyocyte apoptosis through differential subcellular activation of ERK1/2 and Akt.
    Journal of molecular and cellular cardiology, 2014, Volume: 72

    Topics: Adrenergic beta-Agonists; Animals; Animals, Newborn; Apoptosis; Caspase 3; Cats; ErbB Receptors; Gene Expression Regulation; Isoproterenol; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Phosphorylation; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Signal Transduction; Tyrphostins

2014
The epidermal growth factor receptor is a regulator of epidermal complement component expression and complement activation.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Apr-01, Volume: 192, Issue:7

    Topics: Animals; Apoptosis; Blotting, Western; Cell Line; Cells, Cultured; Complement Activation; Complement System Proteins; Epidermal Cells; Epidermis; ErbB Receptors; Gene Expression; Humans; Keratinocytes; Mice; Microscopy, Fluorescence; Oligonucleotide Array Sequence Analysis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Skin; Transcriptome; Transforming Growth Factor alpha; Tyrphostins

2014
Early development of a celiac trunk aneurysm during anti-vascular endothelial growth factor receptor therapy.
    Surgery, 2014, Volume: 155, Issue:4

    Topics: Aged; Aneurysm; Celiac Artery; Enzyme Inhibitors; Female; Humans; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Thyroid Neoplasms; Tomography, X-Ray Computed; Treatment Outcome; Tyrphostins; Withholding Treatment

2014
Autocrine signaling via release of ATP and activation of P2X7 receptor influences motile activity of human lung cancer cells.
    Purinergic signalling, 2014, Volume: 10, Issue:3

    Topics: Adenosine Triphosphate; Autocrine Communication; Cell Line, Tumor; Cell Movement; Humans; Lung Neoplasms; Quinazolines; Receptors, Purinergic P2X7; Tyrphostins

2014
Quantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substances.
    PloS one, 2014, Volume: 9, Issue:3

    Topics: Coated Pits, Cell-Membrane; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; HeLa Cells; Humans; Microscopy, Fluorescence; Quinazolines; Tyrphostins

2014
Dual inhibition of EGFR at protein and activity level via combinatorial blocking of PI4KIIα as anti-tumor strategy.
    Protein & cell, 2014, Volume: 5, Issue:6

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; ErbB Receptors; Female; HSP90 Heat-Shock Proteins; Humans; Male; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Minor Histocompatibility Antigens; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Proto-Oncogene Proteins c-akt; Quinazolines; Transplantation, Heterologous; Tyrphostins

2014
Alpha1a-adrenoceptor genetic variant induces cardiomyoblast-to-fibroblast-like cell transition via distinct signaling pathways.
    Cellular signalling, 2014, Volume: 26, Issue:9

    Topics: Animals; Arrestins; beta-Arrestin 1; beta-Arrestins; Cell Line; Cell Proliferation; Dipeptides; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Humans; Matrix Metalloproteinases; Mutation; Myoblasts, Cardiac; Phenylephrine; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Signal Transduction; src-Family Kinases; Transcriptional Activation; Tyrphostins

2014
MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2014, Volume: 35, Issue:9

    Topics: Blotting, Western; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Matrix Metalloproteinase 9; MicroRNAs; Models, Genetic; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins

2014
Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells.
    Journal of nanobiotechnology, 2014, May-12, Volume: 12

    Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Carriers; ErbB Receptors; Humans; Lipids; Liver; Liver Neoplasms; Nanostructures; Quinazolines; Tyrphostins

2014
Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cells.
    Journal of hematology & oncology, 2014, May-06, Volume: 7

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Azepines; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Immunohistochemistry; Mice; Mice, Nude; Ovarian Neoplasms; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Quinazolines; Receptors, G-Protein-Coupled; Signal Transduction; Triazoles; Tyrphostins; Xenograft Model Antitumor Assays

2014
The human Cathelicidin LL-37 induces MUC5AC mucin production by airway epithelial cells via TACE-TGF-α-EGFR pathway.
    Experimental lung research, 2014, Volume: 40, Issue:7

    Topics: ADAM Proteins; ADAM17 Protein; Antimicrobial Cationic Peptides; Cathelicidins; Cell Line; Epithelial Cells; ErbB Receptors; Humans; Mucin 5AC; Quinazolines; Respiratory Mucosa; Signal Transduction; Transforming Growth Factor alpha; Tyrphostins

2014
Epidermal growth factor receptor is required for estradiol-stimulated bovine satellite cell proliferation.
    Domestic animal endocrinology, 2014, Volume: 48

    Topics: Animals; Cattle; Cell Proliferation; Cells, Cultured; ErbB Receptors; Estradiol; Gene Silencing; Insulin-Like Growth Factor I; Quinazolines; Receptor, IGF Type 1; Satellite Cells, Skeletal Muscle; Tyrphostins

2014
Immediate and long-term consequences of vascular toxicity during zebrafish development.
    Reproductive toxicology (Elmsford, N.Y.), 2014, Volume: 48

    Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Blood Vessels; Embryo, Nonmammalian; Embryonic Development; ErbB Receptors; Phthalazines; Protein Kinase Inhibitors; Pyridines; Quinazolines; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2; Zebrafish

2014
An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction.
    Methods in molecular biology (Clifton, N.J.), 2014, Volume: 1172

    Topics: Animals; Biological Assay; Cell Communication; Cell Line, Tumor; Cell Movement; Coculture Techniques; Collagen Type I; Epidermal Growth Factor; Extracellular Matrix; Female; Fibronectins; Gefitinib; Humans; Macrophages; Mammary Glands, Human; Mice; Molecular Imaging; Quinazolines; Signal Transduction; Time-Lapse Imaging; Tyrphostins

2014
Resistance of oral squamous cell carcinoma cells to cetuximab is associated with EGFR insensitivity and enhanced stem cell-like potency.
    Oncology reports, 2014, Volume: 32, Issue:2

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cetuximab; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Mouth Neoplasms; Phosphorylation; Quinazolines; Stem Cells; Tumor Microenvironment; Tyrphostins

2014
Epidermal growth factor-like domain-containing protein 7 (EGFL7) enhances EGF receptor-AKT signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Animals; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; EGF Family of Proteins; Endothelial Growth Factors; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Transplantation; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Small Interfering; Signal Transduction; Snail Family Transcription Factors; Stomach Neoplasms; Transcription Factors; Tyrphostins; Vimentin

2014
Antagonism of the prostaglandin E2 EP1 receptor in MDCK cells increases growth through activation of Akt and the epidermal growth factor receptor.
    American journal of physiology. Renal physiology, 2014, Sep-01, Volume: 307, Issue:5

    Topics: Animals; Bridged Bicyclo Compounds; Caproates; Cell Proliferation; Dogs; ErbB Receptors; Heterocyclic Compounds, 3-Ring; Hydrazines; Ibuprofen; Kidney; Madin Darby Canine Kidney Cells; Oxazepines; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Signal Transduction; Tyrphostins

2014
Thrombin stimulates VSMC proliferation through an EGFR-dependent pathway: involvement of MMP-2.
    Molecular and cellular biochemistry, 2014, Volume: 396, Issue:1-2

    Topics: Acrylamides; Animals; Cell Proliferation; Cells, Cultured; ErbB Receptors; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Quinazolines; Rats, Wistar; Signal Transduction; Thrombin; Tyrphostins

2014
TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.
    Cell communication and signaling : CCS, 2014, Jul-24, Volume: 12

    Topics: Animals; Antibodies, Neutralizing; Carbazoles; Cerebral Cortex; Enzyme Inhibitors; Female; Humans; Indole Alkaloids; Mice; Mice, Knockout; Neuregulin-1; Neurons; Phospholipase C gamma; Phosphorylation; Quinazolines; Receptor, ErbB-4; Receptor, trkB; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Signal Transduction; Synapses; Tyrphostins

2014
Protease-mediated human smooth muscle cell proliferation by urokinase requires epidermal growth factor receptor transactivation by triple membrane signaling.
    The Journal of surgical research, 2014, Volume: 192, Issue:2

    Topics: ADAM Proteins; ADAM10 Protein; ADAM12 Protein; Amyloid Precursor Protein Secretases; Cell Proliferation; Cells, Cultured; Coronary Vessels; Enzyme Inhibitors; ErbB Receptors; Humans; Membrane Proteins; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Protein Structure, Tertiary; Quinazolines; Receptors, Urokinase Plasminogen Activator; RNA, Small Interfering; Signal Transduction; Tyrphostins; Urokinase-Type Plasminogen Activator

2014
Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.
    Cell death & disease, 2014, Aug-14, Volume: 5

    Topics: Cadmium Chloride; Calcium-Binding Proteins; Cell Line; Chromones; Down-Regulation; Epithelial Cells; ErbB Receptors; Humans; Indoles; Intercellular Signaling Peptides and Proteins; Jagged-1 Protein; Jagged-2 Protein; Kidney Tubules, Proximal; Maleimides; Membrane Proteins; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Receptor, Notch1; RNA Interference; RNA, Small Interfering; Serrate-Jagged Proteins; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Tumor Suppressor Protein p53; Tyrphostins

2014
Induction of fibronectin in response to epidermal growth factor is suppressed by silibinin through the inhibition of STAT3 in triple negative breast cancer cells.
    Oncology reports, 2014, Volume: 32, Issue:5

    Topics: Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Female; Fibronectins; Gefitinib; Humans; MCF-7 Cells; Phosphorylation; Quinazolines; Signal Transduction; Silybin; Silymarin; Triple Negative Breast Neoplasms; Tyrphostins

2014
Epidermal growth factor receptor activity is necessary for mouse basal cell proliferation.
    American journal of physiology. Lung cellular and molecular physiology, 2014, Nov-15, Volume: 307, Issue:10

    Topics: Animals; Benzothiazoles; Cell Proliferation; Enzyme Inhibitors; Female; Humans; Male; Mice; Mice, Transgenic; Naphthalenes; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-2; src-Family Kinases; Stem Cells; Trachea; Tyrphostins

2014
EGFR-AKT-mTOR activation mediates epiregulin-induced pleiotropic functions in cultured osteoblasts.
    Molecular and cellular biochemistry, 2015, Volume: 398, Issue:1-2

    Topics: Alkaline Phosphatase; Animals; Animals, Newborn; Blotting, Western; Carrier Proteins; Cell Death; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Dexamethasone; Enzyme Activation; Enzyme Inhibitors; Epiregulin; ErbB Receptors; MAP Kinase Signaling System; Mice; Osteoblasts; Proto-Oncogene Proteins c-akt; Quinazolines; RNA Interference; TOR Serine-Threonine Kinases; Tyrphostins

2015
Amygdala NRG1-ErbB4 is critical for the modulation of anxiety-like behaviors.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015, Volume: 40, Issue:4

    Topics: Amygdala; Animals; Anxiety; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Feeding Behavior; gamma-Aminobutyric Acid; Gene Expression Regulation; Glutamate Decarboxylase; GPI-Linked Proteins; In Vitro Techniques; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myelin Proteins; Nogo Receptor 1; Pyrimidines; Quinazolines; Reaction Time; Receptor, ErbB-4; Receptors, Cell Surface; Signal Transduction; Tyrphostins

2015
Non-genomic actions of estradiol and 4-OH-tamoxifen on murine breast cancer cells.
    Oncology reports, 2015, Volume: 33, Issue:1

    Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Humans; MCF-7 Cells; Mice; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tamoxifen; Tyrphostins

2015
Epidermal growth factor-network signaling mediates luteinizing hormone regulation of BNP and CNP and their receptor NPR2 during porcine oocyte meiotic resumption.
    Molecular reproduction and development, 2014, Volume: 81, Issue:11

    Topics: Amphiregulin; Animals; Cyclic GMP; DNA Primers; Female; Granulosa Cells; In Situ Hybridization; Luteinizing Hormone; Meiosis; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Oocytes; Quinazolines; Radioimmunoassay; Real-Time Polymerase Chain Reaction; Receptors, Atrial Natriuretic Factor; Signal Transduction; Swine; Tyrphostins

2014
Involvement of endogenous transforming growth factor-α in signal transduction pathway for interleukin-1β-induced hepatocyte proliferation.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: Animals; Cell Cycle; Cell Proliferation; Cells, Cultured; Chromones; DNA; Dose-Response Relationship, Drug; Flavonoids; Hepatocytes; Interleukin 1 Receptor Antagonist Protein; Interleukin-1alpha; Interleukin-1beta; Male; MAP Kinase Signaling System; Morpholines; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Sirolimus; Transforming Growth Factor alpha; Tyrphostins

2014
Inhibition of progression of PanIN through antagonizing EGFR.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:5

    Topics: Animals; Antineoplastic Agents; Carcinoma in Situ; Disease Progression; Drug Screening Assays, Antitumor; ErbB Receptors; Male; Mice, Transgenic; Pancreas; Pancreatic Neoplasms; Quinazolines; Tyrphostins

2015
Co-targeting EGFR and Autophagy Impairs Ovarian Cancer Cell Survival during Detachment from the ECM.
    Current cancer drug targets, 2015, Volume: 15, Issue:3

    Topics: Animals; Antineoplastic Agents; Autophagy; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; ErbB Receptors; Extracellular Matrix; Female; Humans; Mice, SCID; Molecular Targeted Therapy; Ovarian Neoplasms; Peritoneal Neoplasms; Quinazolines; Spheroids, Cellular; Tumor Cells, Cultured; Tyrphostins; Xenograft Model Antitumor Assays

2015
Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface.
    The Journal of biological chemistry, 2015, Mar-27, Volume: 290, Issue:13

    Topics: Animals; Cell Line, Tumor; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Cystine; Endoplasmic Reticulum; ErbB Receptors; Humans; Mice, Inbred C57BL; Mice, Transgenic; Mucoproteins; Oncogene Proteins; Protein Kinase Inhibitors; Protein Transport; Proteins; Quinazolines; Signal Transduction; Thioredoxins; Tyrphostins

2015
A disintegrin and metalloprotease 17 promotes microglial cell survival via epidermal growth factor receptor signalling following spinal cord injury.
    Molecular medicine reports, 2015, Volume: 12, Issue:1

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Apoptosis; Cell Proliferation; Cell Survival; ErbB Receptors; Humans; Mice; Microglia; Neurons; Quinazolines; Signal Transduction; Spinal Cord Injuries; Tyrphostins

2015
EGFR inhibition protects cardiac damage and remodeling through attenuating oxidative stress in STZ-induced diabetic mouse model.
    Journal of molecular and cellular cardiology, 2015, Volume: 82

    Topics: Animals; Apoptosis; Blood Glucose; Body Weight; Cell Line; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Disease Models, Animal; ErbB Receptors; Fibrosis; Male; Mice; Myocardium; Oxidative Stress; Proto-Oncogene Proteins c-akt; Quinazolines; Reactive Oxygen Species; Signal Transduction; Tyrphostins; Ventricular Remodeling

2015
EGFR participates downstream of ERα in estradiol-17β-D-glucuronide-induced impairment of Abcc2 function in isolated rat hepatocyte couplets.
    Archives of toxicology, 2016, Volume: 90, Issue:4

    Topics: Animals; ATP-Binding Cassette Transporters; Bile Canaliculi; Cells, Cultured; Cholestasis; ErbB Receptors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor Antagonists; Female; Fulvestrant; Gene Knockdown Techniques; Hepatocytes; Quinazolines; Rats; Rats, Wistar; src-Family Kinases; Tyrphostins

2016
Neuregulin 1 Type II-ErbB Signaling Promotes Cell Divisions Generating Neurons from Neural Progenitor Cells in the Developing Zebrafish Brain.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Animals; Brain; Cell Division; ErbB Receptors; Gene Expression Regulation, Developmental; Neural Stem Cells; Neuregulin-1; Neurogenesis; Neurons; Quinazolines; Signal Transduction; Tyrphostins; Zebrafish

2015
The Soluble Heparin-Binding EGF-Like Growth Factor Stimulates EGF Receptor Trafficking to the Nucleus.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Cell Line; Cell Nucleus; Cyclin D1; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Humans; Ligands; Phosphorylation; Promoter Regions, Genetic; Protein Kinase Inhibitors; Protein Transport; Quinazolines; Tyrphostins

2015
Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse.
    Biochimica et biophysica acta, 2015, Volume: 1853, Issue:10 Pt A

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Cytochrome b Group; Diabetes Mellitus, Type 2; Diabetic Angiopathies; ErbB Receptors; Mice; Mice, Knockout; NADPH Oxidase 4; NADPH Oxidases; Phenylephrine; Quinazolines; Tyrphostins; Vasoconstriction; Vasodilation

2015
Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Adolescent; Air; Asthma; Bronchi; Cell Count; Cell Differentiation; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Electric Impedance; Epidermal Growth Factor; Female; Goblet Cells; Humans; Infant; Male; Models, Biological; Mucin 5AC; Quinazolines; RNA, Messenger; Tyrphostins

2015
t-Darpp Promotes Enhanced EGFR Activation and New Drug Synergies in Her2-Positive Breast Cancer Cells.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Dopamine and cAMP-Regulated Phosphoprotein 32; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Humans; Quinazolines; Receptor, ErbB-2; Trastuzumab; Tyrphostins

2015
The Sbi Protein Contributes to Staphylococcus aureus Inflammatory Response during Systemic Infection.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Animals; Bacterial Proteins; Binding Sites, Antibody; Carrier Proteins; Chemokine CXCL1; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Imidazoles; Immunoglobulin G; Inflammation; Interleukin-6; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neutrophil Infiltration; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Pyridines; Quinazolines; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Staphylococcal Infections; Staphylococcal Protein A; Staphylococcus aureus; Tyrphostins; Virulence Factors

2015
Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:10

    Topics: Animals; Benzoxazines; Cartilage, Articular; Chemokine CCL2; Disease Models, Animal; Disease Progression; Male; Osteoarthritis; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiro Compounds; Transforming Growth Factor alpha; Tyrphostins; Up-Regulation; Wounds and Injuries

2015
Rapidly activated epidermal growth factor receptor mediates lipopolysaccharide-triggered migration of microglia.
    Neurochemistry international, 2015, Volume: 90

    Topics: Animals; Cell Movement; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Microglia; Phosphorylation; Quinazolines; Rats, Wistar; Tyrphostins

2015
Modulatory Effects of Curcumin and Tyrphostins (AG494 and AG1478) on Growth Regulation and Viability of LN229 Human Brain Cancer Cells.
    Nutrition and cancer, 2015, Volume: 67, Issue:7

    Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Curcumin; DNA Damage; ErbB Receptors; Humans; Protein Kinase Inhibitors; Quinazolines; Reactive Oxygen Species; Tyrphostins

2015
HPW-RX40 restores anoikis sensitivity of human breast cancer cells by inhibiting integrin/FAK signaling.
    Toxicology and applied pharmacology, 2015, Dec-01, Volume: 289, Issue:2

    Topics: Anoikis; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Adhesion; Cell Aggregation; Cell Line, Tumor; Chlorobenzoates; Dose-Response Relationship, Drug; Enzyme Activation; ErbB Receptors; Female; Focal Adhesion Kinase 1; Humans; Integrin beta1; Paxillin; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; src-Family Kinases; Styrenes; Tyrphostins

2015
Zinc pyrithione inhibits caspase-3 activity, promotes ErbB1-ErbB2 heterodimerization and suppresses ErbB2 downregulation in cardiomyocytes subjected to ischemia/reperfusion.
    Journal of inorganic biochemistry, 2015, Volume: 153

    Topics: Amino Acid Chloromethyl Ketones; Animals; Benzothiazoles; Cardiotonic Agents; Caspase 3; Caspase Inhibitors; Cell Hypoxia; Chlorides; Down-Regulation; ErbB Receptors; Lapatinib; Leupeptins; Myocytes, Cardiac; Organometallic Compounds; Phosphorylation; Proteasome Inhibitors; Protein Kinase Inhibitors; Protein Multimerization; Pyridines; Quinazolines; Rats; Receptor, ErbB-2; RNA, Messenger; Thiones; Tyrphostins; Zinc Compounds

2015
Role of G protein-coupled receptors (GPCR), matrix metalloproteinases 2 and 9 (MMP2 and MMP9), heparin-binding epidermal growth factor-like growth factor (hbEGF), epidermal growth factor receptor (EGFR), erbB2, and insulin-like growth factor 1 receptor (I
    Journal of animal science, 2015, Volume: 93, Issue:9

    Topics: Androgens; Animals; Cattle; Cell Proliferation; Cells, Cultured; Estradiol; Estrogens; Gene Expression Regulation; Genes, erbB-2; Heparin; Heparin-binding EGF-like Growth Factor; Insulin-Like Growth Factor I; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Quinazolines; Receptor, IGF Type 1; Receptors, G-Protein-Coupled; Satellite Cells, Skeletal Muscle; Trenbolone Acetate; Tyrphostins

2015
The P2RY2 Receptor Induces Carcinoma Cell Migration and EMT Through Cross-Talk With Epidermal Growth Factor Receptor.
    Journal of cellular biochemistry, 2016, Volume: 117, Issue:4

    Topics: Androstadienes; Cadherins; Cell Line, Tumor; Cell Movement; Epithelial Cells; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Ovary; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Receptor Cross-Talk; Receptors, Purinergic P2Y2; Signal Transduction; Snail Family Transcription Factors; Transcription Factors; Tyrphostins; Uridine Triphosphate; Vimentin; Wortmannin

2016
Protein phosphatase 2A (PP2A) activation promotes axonal growth and recovery in the CNS.
    Journal of the neurological sciences, 2015, Dec-15, Volume: 359, Issue:1-2

    Topics: Animals; Axons; Biotin; Cells, Cultured; Chondroitin Sulfate Proteoglycans; Dextrans; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Male; Mutation; Myelin Basic Protein; Neurons; Phosphorylation; Protein Phosphatase 2; Quinazolines; Rats; Rats, Sprague-Dawley; Recovery of Function; Sphingosine; Spinal Cord Injuries; Tyrphostins

2015
[Research of the influence and mechanism about metformin on the proliferation of differentiated endometrial carcinoma cells].
    Zhonghua fu chan ke za zhi, 2015, Volume: 50, Issue:9

    Topics: Antineoplastic Agents; Cell Differentiation; Cell Proliferation; Down-Regulation; Endometrial Neoplasms; Endometrium; Female; Humans; Hypoglycemic Agents; Metformin; Mitogen-Activated Protein Kinase 3; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins

2015
Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells.
    Scientific reports, 2016, Jan-05, Volume: 6

    Topics: Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; ErbB Receptors; Female; Gene Deletion; Gene Expression; Gene Knockout Techniques; Humans; Integrin beta1; Protein Kinase Inhibitors; Protein Subunits; Quinazolines; Signal Transduction; Tyrphostins

2016
Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II.
    Journal of cellular and molecular medicine, 2016, Volume: 20, Issue:3

    Topics: Angiotensin II; Animals; Cardiomegaly; Cardiotonic Agents; Cell Line; Drug Evaluation, Preclinical; Epidermal Growth Factor; ErbB Receptors; Gene Knockdown Techniques; Mice, Inbred C57BL; Myocytes, Cardiac; Quinazolines; Rats; Tyrphostins

2016
Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system.
    Neurobiology of disease, 2016, Volume: 88

    Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Chelating Agents; Cuprizone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; ErbB Receptors; Female; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin Proteolipid Protein; Oligodendroglia; Peptide Fragments; Proteoglycans; Quinazolines; Stem Cells; Thymosin; Time Factors; Tyrphostins

2016
Exercise training activates neuregulin 1/ErbB signaling and promotes cardiac repair in a rat myocardial infarction model.
    Life sciences, 2016, Mar-15, Volume: 149

    Topics: Animals; Disease Models, Animal; Male; Myocardial Infarction; Neuregulin-1; Oncogene Proteins v-erbB; Physical Conditioning, Animal; Quinazolines; Rats; Rats, Sprague-Dawley; Tyrphostins

2016
Inhibitory effect of luteolin on the proliferation of human breast cancer cell lines induced by epidermal growth factor.
    Sheng li xue bao : [Acta physiologica Sinica], 2016, Feb-25, Volume: 68, Issue:1

    Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Luteolin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Quinazolines; Tyrphostins

2016
Epidermal Growth Factor Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:5

    Topics: Benzamides; Breast; Cell Line; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Drug Synergism; Epithelial Cells; ErbB Receptors; Gefitinib; Humans; MAP Kinase Kinase 1; Morpholines; Polychlorinated Dibenzodioxins; Protein Kinase Inhibitors; Quinazolines; RNA, Messenger; Tyrphostins

2016
Inhibition of the Ras-ERK pathway in mitotic COS7 cells is due to the inability of EGFR/Raf to transduce EGF signaling to downstream proteins.
    Oncology reports, 2016, Volume: 35, Issue:6

    Topics: Animals; Caveolins; Cell Line; Chlorocebus aethiops; Clathrin; COS Cells; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; MAP Kinase Signaling System; Nocodazole; Phosphorylation; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Quinazolines; raf Kinases; Shc Signaling Adaptor Proteins; Tetradecanoylphorbol Acetate; Tyrphostins

2016
EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation.
    Oncotarget, 2016, Apr-26, Volume: 7, Issue:17

    Topics: Animals; Cell Line; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; ErbB Receptors; Hyperlipidemias; Immunoblotting; Inflammation; Kidney; Male; Mice, Inbred C57BL; Mice, Knockout; Obesity; Oxidative Stress; Phosphorylation; Quinazolines; Rats; RNA Interference; src-Family Kinases; Tyrphostins

2016
Impact of PAMAM delivery systems on signal transduction pathways in vivo: Modulation of ERK1/2 and p38 MAP kinase signaling in the normal and diabetic kidney.
    International journal of pharmaceutics, 2016, Dec-05, Volume: 514, Issue:2

    Topics: Animals; Blood Glucose; Cyclic N-Oxides; Dendrimers; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; ErbB Receptors; Kidney; Male; MAP Kinase Signaling System; Phosphorylation; Quinazolines; Rats; Spin Labels; Tyrphostins

2016
Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells.
    Oncotarget, 2016, Oct-04, Volume: 7, Issue:40

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cetuximab; Colonic Neoplasms; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Resistance, Neoplasm; Drug Therapy, Combination; ErbB Receptors; Humans; Quinazolines; RNA, Small Interfering; Transcriptome; Tyrphostins

2016
Regulation of Viral Infection-induced Airway Remodeling Cytokine Production by the TLR3-EGFR Signaling Pathway in Human Bronchial Epithelial Cells.
    COPD, 2016, Volume: 13, Issue:6

    Topics: Airway Remodeling; Antiviral Agents; Bronchi; Cells, Cultured; Cytokines; ErbB Receptors; Flavonoids; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Mucin 5AC; p38 Mitogen-Activated Protein Kinases; Poly I-C; Protein Kinase Inhibitors; Quinazolines; Respiratory Mucosa; RNA, Messenger; Toll-Like Receptor 3; Transforming Growth Factor beta1; Tyrphostins; Vascular Endothelial Growth Factor A; Virus Diseases

2016
Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats.
    Brain research, 2016, 07-01, Volume: 1642

    Topics: Animals; Cerebral Arteries; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Male; Models, Animal; Quinazolines; Random Allocation; Rats, Sprague-Dawley; Recombinant Proteins; Tenascin; Tyrphostins; Vasoconstriction; Vasospasm, Intracranial

2016
EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice.
    Scientific reports, 2016, Apr-18, Volume: 6

    Topics: Animals; Apolipoproteins E; Apoptosis; Cardiovascular Diseases; Cell Line; Diet, High-Fat; ErbB Receptors; Hyperlipidemias; Male; Mice; Mice, Inbred C57BL; Myocytes, Cardiac; Palmitic Acid; Protein Kinase Inhibitors; Quinazolines; Rats; src-Family Kinases; Toll-Like Receptor 4; Tyrphostins

2016
UV-Vis spectroscopy and solvatochromism of the tyrosine kinase inhibitor AG-1478.
    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2016, 07-05, Volume: 164

    Topics: Hydrogen Bonding; Protein Kinase Inhibitors; Quinazolines; Solvents; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Tyrphostins

2016
ADAM17-siRNA inhibits MCF-7 breast cancer through EGFR-PI3K-AKT activation.
    International journal of oncology, 2016, Volume: 49, Issue:2

    Topics: ADAM17 Protein; Animals; Benzamides; Breast Neoplasms; Chromones; Diphenylamine; ErbB Receptors; Female; Humans; MCF-7 Cells; Mice; Morpholines; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; RNA, Small Interfering; Signal Transduction; Tyrphostins; Xenograft Model Antitumor Assays

2016
Phytanic acid activates NADPH oxidase through transactivation of epidermal growth factor receptor in vascular smooth muscle cells.
    Lipids in health and disease, 2016, Jun-10, Volume: 15

    Topics: Animals; Aorta; Cattle; Cell Separation; Culture Media; Dose-Response Relationship, Drug; Enzyme Inhibitors; ErbB Receptors; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NADPH Oxidases; Phosphoproteins; Phosphorylation; Phytanic Acid; Primary Cell Culture; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Transcriptional Activation; Tyrphostins

2016
Nitric Oxide and ERK mediates regulation of cellular processes by Ecdysterone.
    Experimental cell research, 2016, 08-15, Volume: 346, Issue:2

    Topics: 3T3-L1 Cells; Aizoaceae; Animals; Cell Migration Assays; Cell Movement; Cell Proliferation; Ecdysterone; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Mice; Nitric Oxide; Quinazolines; Signal Transduction; Tyrphostins

2016
Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:10

    Topics: 1-Phosphatidylinositol 4-Kinase; Antiviral Agents; Dose-Response Relationship, Drug; Encephalomyocarditis virus; Enzyme Inhibitors; HeLa Cells; Hepacivirus; Humans; Molecular Targeted Therapy; Mutation; Quinazolines; Tyrphostins; Virus Replication

2016
New EGFR inhibitor, 453, prevents renal fibrosis in angiotensin II-stimulated mice.
    European journal of pharmacology, 2016, Oct-15, Volume: 789

    Topics: Angiotensin II; Animals; Apoptosis; ErbB Receptors; Fibrosis; Kidney; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Tyrphostins

2016
The role of RNase 7 in innate cutaneous defense against Pseudomonas aeruginosa.
    Experimental dermatology, 2017, Volume: 26, Issue:3

    Topics: ADAM17 Protein; Antibodies, Neutralizing; Cells, Cultured; Cetuximab; Epidermis; ErbB Receptors; Gene Expression; Gene Silencing; Humans; Hydroxamic Acids; Keratinocytes; Organoids; Pseudomonas aeruginosa; Quinazolines; Ribonucleases; RNA, Small Interfering; Signal Transduction; Skin; Toll-Like Receptor 5; Tyrphostins

2017
ADAM17 and EGFR regulate IL-6 receptor and amphiregulin mRNA expression and release in cigarette smoke-exposed primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD).
    Physiological reports, 2016, Volume: 4, Issue:16

    Topics: ADAM17 Protein; Aged; Airway Remodeling; Amphiregulin; Bronchi; Epithelial Cells; ErbB Receptors; Female; Humans; Inhalation Exposure; Male; Middle Aged; Nicotiana; Pulmonary Disease, Chronic Obstructive; Quinazolines; Receptors, Interleukin-6; RNA, Messenger; Signal Transduction; Smoking; Tyrphostins

2016
EGFR transactivation contributes to neuroinflammation in Streptococcus suis meningitis.
    Journal of neuroinflammation, 2016, 10-19, Volume: 13, Issue:1

    Topics: Amphiregulin; Animals; Brain; Cytokines; Endothelial Cells; Enzyme Inhibitors; ErbB Receptors; Female; Humans; Meningitis; Mice; Phosphorylation; Quinazolines; Receptor, ErbB-3; Signal Transduction; Streptococcal Infections; Streptococcus suis; Swine; Transcriptional Activation; Tyrosine; Tyrphostins

2016
Anterior Gradient 2 (AGR2) Induced Epidermal Growth Factor Receptor (EGFR) Signaling Is Essential for Murine Pancreatitis-Associated Tissue Regeneration.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Animals; Cell Proliferation; Ceruletide; ErbB Receptors; Female; Gene Dosage; Gene Expression Regulation; Hippo Signaling Pathway; Humans; Mice; Mice, Inbred C57BL; Mucoproteins; Oncogene Proteins; Pancreatitis; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Quinazolines; Regeneration; Signal Transduction; Tyrphostins

2016
Blocking NOTCH pathway can enhance the effect of EGFR inhibitor through targeting CD133+ endometrial cancer cells.
    Cancer biology & therapy, 2018, 02-01, Volume: 19, Issue:2

    Topics: AC133 Antigen; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinogenesis; Cell Line, Tumor; Diamines; Drug Resistance, Neoplasm; Drug Synergism; Endometrial Neoplasms; ErbB Receptors; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Quinazolines; Receptors, Notch; Signal Transduction; Thiazoles; Tyrphostins; Xenograft Model Antitumor Assays

2018
Sprouty2 inhibits amphiregulin-induced down-regulation of E-cadherin and cell invasion in human ovarian cancer cells.
    Oncotarget, 2016, Dec-06, Volume: 7, Issue:49

    Topics: Amphiregulin; Antigens, CD; Antineoplastic Agents; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease-Free Survival; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Ligands; Membrane Proteins; Neoplasm Invasiveness; Ovarian Neoplasms; Protein Binding; Quinazolines; RNA Interference; Signal Transduction; Snail Family Transcription Factors; Time Factors; Tyrphostins

2016
Neuroinflammation-Induced Downregulation of Hippocampacal Neuregulin 1-ErbB4 Signaling in the Parvalbumin Interneurons Might Contribute to Cognitive Impairment in a Mouse Model of Sepsis-Associated Encephalopathy.
    Inflammation, 2017, Volume: 40, Issue:2

    Topics: Animals; Cognitive Dysfunction; Disease Models, Animal; Down-Regulation; Encephalitis; Enzyme Inhibitors; Gamma Rhythm; Hippocampus; Interneurons; Mice; Neuregulin-1; Parvalbumins; Quinazolines; Receptor, ErbB-4; Sepsis-Associated Encephalopathy; Signal Transduction; Tyrphostins

2017
Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer.
    Oncotarget, 2017, Jan-24, Volume: 8, Issue:4

    Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Movement; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxyprostaglandin Dehydrogenases; MCF-7 Cells; Mice, Inbred BALB C; Mice, SCID; Multidrug Resistance-Associated Proteins; Neoplasm Metastasis; Organic Anion Transporters; Propionates; Quinazolines; Quinolines; Receptors, Prostaglandin E, EP4 Subtype; RNA Interference; Signal Transduction; Time Factors; Transfection; Triple Negative Breast Neoplasms; Tumor Microenvironment; Tyrphostins

2017
Quantifying receptor trafficking and colocalization with confocal microscopy.
    Methods (San Diego, Calif.), 2017, 02-15, Volume: 115

    Topics: Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; HeLa Cells; Humans; Hydrazones; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Protein Transport; Quinazolines; rab5 GTP-Binding Proteins; Recombinant Fusion Proteins; Red Fluorescent Protein; Transformation, Genetic; Tyrphostins

2017
Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma.
    International journal of molecular sciences, 2017, Jan-26, Volume: 18, Issue:2

    Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Drug Synergism; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Head and Neck Neoplasms; Humans; Mutant Proteins; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Quinazolines; Rotenone; Squamous Cell Carcinoma of Head and Neck; Time Factors; Tyrphostins

2017
Hypoxic proliferation requires EGFR-mediated ERK activation in human pulmonary microvascular endothelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2017, 05-01, Volume: 312, Issue:5

    Topics: Arginase; Butadienes; Cell Count; Cell Hypoxia; Cell Proliferation; Cell Survival; Culture Media, Conditioned; Endothelial Cells; Enzyme Activation; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Gene Silencing; Humans; Lung; Microvessels; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; RNA, Small Interfering; Tyrphostins

2017
Effects of arachidonic acid on FFA4 receptor: Signaling, phosphorylation and internalization.
    Prostaglandins, leukotrienes, and essential fatty acids, 2017, Volume: 117

    Topics: Arachidonic Acid; beta-Arrestins; Calcium; Cell Line; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Phosphorylation; Quinazolines; Receptors, G-Protein-Coupled; Signal Transduction; Tyrphostins

2017
Inactivation of EGFR/AKT signaling enhances TSA-induced ovarian cancer cell differentiation.
    Oncology reports, 2017, Volume: 37, Issue:5

    Topics: Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Ovarian Neoplasms; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins

2017
EGFR inhibition attenuates diabetic nephropathy through decreasing ROS and endoplasmic reticulum stress.
    Oncotarget, 2017, May-16, Volume: 8, Issue:20

    Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Endoplasmic Reticulum Stress; ErbB Receptors; Humans; Mice; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reactive Oxygen Species; Streptozocin; Transforming Growth Factor beta; Tyrphostins

2017
Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.
    Oncology reports, 2017, Volume: 37, Issue:6

    Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cetuximab; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Indoles; Mouth Neoplasms; Phosphatidylinositol 3-Kinases; Piperazines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pseudopodia; Quinazolines; Signal Transduction; Sulfonamides; Tyrphostins

2017
Inhibition of epidermal growth factor receptor attenuates LPS-induced inflammation and acute lung injury in rats.
    Oncotarget, 2017, Apr-18, Volume: 8, Issue:16

    Topics: Acute Lung Injury; Animals; Cell Line; CSK Tyrosine-Protein Kinase; Cytokines; ErbB Receptors; Inflammation Mediators; Lipopolysaccharides; Macrophages; Protein Kinase Inhibitors; Quinazolines; Rats; Signal Transduction; src-Family Kinases; Toll-Like Receptor 4; Tyrphostins

2017
Reversible meiotic arrest of bovine oocytes by EGFR inhibition and follicular hemisections.
    Theriogenology, 2017, Sep-01, Volume: 99

    Topics: Angiotensin II; Animals; Cattle; Cell Cycle Checkpoints; Cumulus Cells; Dinoprostone; Embryo Culture Techniques; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation; Granulosa Cells; In Vitro Oocyte Maturation Techniques; Meiosis; Oocytes; Ovarian Follicle; Quinazolines; RNA, Messenger; Signal Transduction; Tyrphostins

2017
Influence and mechanism of 5-aminolevulinic acid-photodynamic therapy on the metastasis of esophageal carcinoma.
    Photodiagnosis and photodynamic therapy, 2017, Volume: 20

    Topics: Aminolevulinic Acid; Animals; Apoptosis; Cell Line, Tumor; Cell Survival; Chromones; Down-Regulation; Drug Therapy, Combination; Esophageal Neoplasms; Female; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Morpholines; Photochemotherapy; Photosensitizing Agents; Protein Kinases; Quinazolines; Signal Transduction; Tyrphostins

2017
Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model.
    Scientific reports, 2017, 08-30, Volume: 7, Issue:1

    Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Down-Regulation; ErbB Receptors; Humans; Indoles; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; NF-kappa B; Ovalbumin; Phosphorylation; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Signal Transduction; Sulfonamides; Transcriptional Activation; Tyrphostins

2017
Inhibition of EGFR attenuates fibrosis and stellate cell activation in diet-induced model of nonalcoholic fatty liver disease.
    Biochimica et biophysica acta. Molecular basis of disease, 2018, Volume: 1864, Issue:1

    Topics: Animals; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; ErbB Receptors; Hepatic Stellate Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Quinazolines; Rats; Tyrphostins

2018
Suppressors for Human Epidermal Growth Factor Receptor 2/4 (HER2/4): A New Family of Anti-Toxoplasmic Agents in ARPE-19 Cells.
    The Korean journal of parasitology, 2017, Volume: 55, Issue:5

    Topics: Afatinib; Aminoquinolines; Aniline Compounds; Animals; Cell Line; Gefitinib; Humans; Mice, Inbred BALB C; Protein Kinase Inhibitors; Quinazolines; Quinazolinones; Quinolines; Receptor, ErbB-2; Toxoplasma; Tyrphostins

2017
The epidermal growth factor receptor inhibitor AG1478 inhibits eosinophilic inflammation in upper airways.
    Clinical immunology (Orlando, Fla.), 2018, Volume: 188

    Topics: Administration, Intranasal; Animals; Cells, Cultured; Chemokine CCL11; Chemokine CCL5; Enzyme Inhibitors; Eosinophilia; Eosinophils; Epithelial Cells; ErbB Receptors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Inflammation; Nasal Mucosa; Neutrophil Infiltration; Quinazolines; Rats; Respiratory Mucosa; Thrombin; Tyrphostins

2018
Poly (ethylene-co-vinyl alcohol) is a suitable substrate for human olfactory neuroepithelial cell differentiation in vitro through a defined regulatory pathway.
    Acta biomaterialia, 2018, 03-01, Volume: 68

    Topics: Amphiregulin; Biomarkers; Cell Differentiation; Cells, Cultured; Humans; Neuroepithelial Cells; Neurons; Neuropeptide Y; Olfactory Mucosa; Polyvinyls; Quinazolines; Schwann Cells; Signal Transduction; Tyrphostins

2018
The activation of G protein-coupled estrogen receptor induces relaxation via cAMP as well as potentiates contraction via EGFR transactivation in porcine coronary arteries.
    PloS one, 2018, Volume: 13, Issue:1

    Topics: Animals; Cells, Cultured; Coronary Vessels; Cyclopentanes; ErbB Receptors; Flavonoids; Humans; In Vitro Techniques; MAP Kinase Signaling System; Models, Cardiovascular; Myocytes, Smooth Muscle; Quinazolines; Quinolines; Receptors, Estrogen; Receptors, G-Protein-Coupled; Swine; Transcriptional Activation; Tyrphostins; Vasodilation

2018
Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II).
    Pain, 2018, Volume: 159, Issue:5

    Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Hyperalgesia; Male; Nociceptors; Pain Threshold; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Signal Transduction; Tyrphostins

2018
TGF-β1 promotes cell barrier function upon maturation of corneal endothelial cells.
    Scientific reports, 2018, 03-13, Volume: 8, Issue:1

    Topics: Adult; Aged; Antigens, CD; Benzamides; Cadaver; Cadherins; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Dioxoles; Endothelial Cells; Endothelium, Corneal; Humans; Intercellular Junctions; Middle Aged; Phenotype; Quinazolines; Transforming Growth Factor beta1; Tyrphostins; Young Adult; Zonula Occludens-1 Protein

2018
Epidermal Growth Factor Receptor Regulation of Ewing Sarcoma Cell Function.
    Oncology, 2018, Volume: 94, Issue:6

    Topics: Bone Neoplasms; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; G1 Phase Cell Cycle Checkpoints; Humans; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Sarcoma, Ewing; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins

2018
EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non‑small cell lung cancer cells.
    Oncology reports, 2018, Volume: 40, Issue:1

    Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Molecular Targeted Therapy; Quinazolines; Telomerase; Tyrphostins

2018
Role of EGFL7/EGFR-signaling pathway in migration and invasion of growth hormone-producing pituitary adenomas.
    Science China. Life sciences, 2018, Volume: 61, Issue:8

    Topics: Adenoma; Animals; Calcium-Binding Proteins; Cell Line, Tumor; Cell Movement; EGF Family of Proteins; Endothelial Growth Factors; Enzyme Inhibitors; ErbB Receptors; Growth Hormone-Secreting Pituitary Adenoma; Humans; Mice; Neoplasm Invasiveness; Quinazolines; Rats; RNA Interference; Signal Transduction; Tyrphostins

2018
Inhibition of Epidermal Growth Factor Receptor (EGFR) Reduces Lipopolysaccharide (LPS)-Induced Activation and Inflammatory Cytokines in Hepatic Stellate Cells In Vitro.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Aug-09, Volume: 24

    Topics: Animals; Cell Proliferation; Cell Survival; Cytokines; ErbB Receptors; Extracellular Matrix; Gene Knockdown Techniques; Genes, src; Hepatic Stellate Cells; Inflammation; Lipopolysaccharides; Liver; Liver Cirrhosis; Male; NF-kappa B; Primary Cell Culture; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Toll-Like Receptor 4; Transforming Growth Factor beta; Tyrphostins

2018
FOS, a Critical Downstream Mediator of PGR and EGF Signaling Necessary for Ovulatory Prostaglandins in the Human Ovary.
    The Journal of clinical endocrinology and metabolism, 2018, 11-01, Volume: 103, Issue:11

    Topics: Adult; Benzophenones; Cells, Cultured; Chorionic Gonadotropin; Dinoprostone; Epidermal Growth Factor; Female; Humans; Isoxazoles; Mifepristone; Ovarian Follicle; Ovulation; Primary Cell Culture; Progesterone; Proto-Oncogene Proteins c-fos; Quinazolines; Receptors, Progesterone; RNA, Small Interfering; Signal Transduction; Tyrphostins; Up-Regulation

2018
EGFR inhibitor, AG1478, inhibits inflammatory infiltration and angiogenesis in mice with diabetic retinopathy.
    Clinical and experimental pharmacology & physiology, 2019, Volume: 46, Issue:1

    Topics: Animals; Diabetic Retinopathy; Disease Progression; ErbB Receptors; Female; Inflammation; Macrophages; Male; Mice; Mitochondria; Neovascularization, Pathologic; Protein Kinase Inhibitors; Quinazolines; Retinal Vessels; Tyrphostins

2019
Label-free imaging of epidermal growth factor receptor-induced response in single living cells.
    The Analyst, 2018, Nov-07, Volume: 143, Issue:21

    Topics: Cell Line, Tumor; Cytochalasin B; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Microscopy, Fluorescence; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Single-Cell Analysis; Surface Plasmon Resonance; Tyrphostins

2018
Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 50, Issue:1

    Topics: Amiloride; Animals; Cell Line; Epithelial Cells; Epithelial Sodium Channels; Hypotonic Solutions; Kidney; Kinetics; Models, Theoretical; Protein Kinase Inhibitors; Protein Transport; Quinazolines; Sodium; Tyrphostins; Xenopus laevis

2018
Anti-vasospastic Effects of Epidermal Growth Factor Receptor Inhibitors After Subarachnoid Hemorrhage in Mice.
    Molecular neurobiology, 2019, Volume: 56, Issue:7

    Topics: Animals; Cetuximab; ErbB Receptors; Male; MAP Kinase Signaling System; Mice, Inbred C57BL; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Subarachnoid Hemorrhage; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Vasospasm, Intracranial

2019
ErbB4 Receptors in the Medial Habenula Regulate Contextual Fear Memory.
    Pharmacology, 2019, Volume: 103, Issue:1-2

    Topics: Animals; Behavior Rating Scale; Conditioning, Classical; Fear; Freezing Reaction, Cataleptic; Habenula; Male; Memory; Mice; Mice, Inbred C57BL; Miniature Postsynaptic Potentials; Neuregulin-1; Pyrimidines; Quinazolines; Receptor, ErbB-4; RNA, Messenger; Tyrphostins

2019
Roles for HB-EGF in Mesenchymal Stromal Cell Proliferation and Differentiation During Skeletal Growth.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2019, Volume: 34, Issue:2

    Topics: Animals; Bone Resorption; Cell Differentiation; Cell Proliferation; Chondrocytes; Heparin-binding EGF-like Growth Factor; MAP Kinase Signaling System; Mesenchymal Stem Cells; Mice; Mice, Transgenic; Osteoblasts; Proto-Oncogene Proteins c-akt; Quinazolines; Skeleton; Smad Proteins; Tyrphostins

2019
Differences in embryonic gene expression and quality indicate the benefit of epidermal growth factor receptor inhibitor during prematuration to improve competence in bovine oocytes.
    Reproduction in domestic animals = Zuchthygiene, 2019, Volume: 54, Issue:4

    Topics: Animals; Cattle; Embryo, Mammalian; Embryonic Development; Enzyme Inhibitors; Epidermal Growth Factor; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; In Vitro Oocyte Maturation Techniques; Quinazolines; Tyrphostins

2019
Combined quantification of intracellular (phospho-)proteins and transcriptomics from fixed single cells.
    Scientific reports, 2019, 02-06, Volume: 9, Issue:1

    Topics: Cell Differentiation; Cells, Cultured; Focal Adhesion Kinase 1; Gene Expression Profiling; Gene Expression Regulation; Humans; Keratinocytes; Phosphorylation; Proteomics; Quinazolines; Single-Cell Analysis; Tissue Fixation; Tyrphostins

2019
Ultrasensitive amplification-free detection of protein kinase based on catalyzed assembly and enumeration of gold nanoparticles.
    Chemical communications (Cambridge, England), 2019, Feb-21, Volume: 55, Issue:17

    Topics: Adenosine Triphosphate; Adsorption; Animals; Biotin; Cattle; Cyclic AMP-Dependent Protein Kinases; Drug Evaluation, Preclinical; Ellagic Acid; Enzyme Assays; Gold; Humans; Immobilized Proteins; Limit of Detection; MCF-7 Cells; Metal Nanoparticles; Oligopeptides; Protein Kinase Inhibitors; Quinazolines; Streptavidin; Tyrphostins

2019
Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion.
    Behavioural brain research, 2019, 06-03, Volume: 365

    Topics: Animals; Apoptosis; Brain Ischemia; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Male; Maze Learning; Memory; Neuregulin-1; Neurons; Neuroprotective Agents; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, ErbB-4; Spatial Learning; Temporal Lobe; Tyrphostins

2019
Stimulation of neuroendocrine differentiation in prostate cancer cells by GHRH and its blockade by GHRH antagonists.
    Investigational new drugs, 2020, Volume: 38, Issue:3

    Topics: Androgens; Cell Adhesion; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Growth Hormone-Releasing Hormone; Humans; Male; Neuroendocrine Cells; PC-3 Cells; Prostatic Neoplasms; Quinazolines; Receptor, ErbB-2; Tyrphostins

2020
Activation of Protein Kinase Cδ Contributes to the Induction of Src/EGF Receptor/ERK Signaling in Ammonia-treated Astrocytes.
    Journal of molecular neuroscience : MN, 2020, Volume: 70, Issue:7

    Topics: Ammonia; Animals; Astrocytes; Cell Size; Cells, Cultured; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Indoles; Maleimides; Protein Kinase C-delta; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; Tyrphostins

2020
EGFR inhibitor AG1478 blocks the formation of 3D structures mainly through ERK signaling pathway in Matrigel-induced 3D reconstruction of eccrine sweat gland-like structures.
    Journal of molecular histology, 2020, Volume: 51, Issue:2

    Topics: Cell Culture Techniques; Cells, Cultured; Collagen; Drug Combinations; Eccrine Glands; ErbB Receptors; Humans; Janus Kinases; Laminin; MAP Kinase Signaling System; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tyrphostins

2020
Attenuating the Epidermal Growth Factor Receptor-Extracellular Signal-Regulated Kinase-Sex-Determining Region Y-Box 9 Axis Promotes Liver Progenitor Cell-Mediated Liver Regeneration in Zebrafish.
    Hepatology (Baltimore, Md.), 2021, Volume: 73, Issue:4

    Topics: Animals; Animals, Genetically Modified; Butadienes; Cell Differentiation; Enzyme Inhibitors; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Hepatocytes; Liver Regeneration; MAP Kinase Signaling System; Nitriles; Quinazolines; SOX9 Transcription Factor; Stem Cells; Tyrphostins; Zebrafish

2021
Expression and pharmacological inhibition of TrkB and EGFR in glioblastoma.
    Molecular biology reports, 2020, Volume: 47, Issue:9

    Topics: Animals; Antineoplastic Agents; Azepines; Benzamides; Brain Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Synergism; Enzyme Inhibitors; ErbB Receptors; Glioblastoma; Humans; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Grading; Protein Kinase Inhibitors; Quinazolines; Receptor, trkB; Tyrphostins; Xenograft Model Antitumor Assays

2020
Normal vitreous promotes angiogenesi via the epidermal growth factor receptor.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020, Volume: 34, Issue:11

    Topics: Cell Movement; ErbB Receptors; Human Umbilical Vein Endothelial Cells; Humans; Neovascularization, Physiologic; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Tissue Extracts; Tyrphostins; Vitreous Body

2020
Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells.
    BioMed research international, 2020, Volume: 2020

    Topics: Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Gold; Head and Neck Neoplasms; Humans; Metal Nanoparticles; Microscopy, Electron, Transmission; Quinazolines; Spectrum Analysis, Raman; Squamous Cell Carcinoma of Head and Neck; Tyrphostins

2020
TNF-α-induced sympathetic excitation requires EGFR and ERK1/2 signaling in cardiovascular regulatory regions of the forebrain.
    American journal of physiology. Heart and circulatory physiology, 2021, 02-01, Volume: 320, Issue:2

    Topics: Animals; Blood Pressure; Cardiovascular System; ErbB Receptors; Heart Rate; Hemodynamics; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Prosencephalon; Protein Kinase Inhibitors; Quinazolines; Rats, Sprague-Dawley; Signal Transduction; Sympathetic Nervous System; Tumor Necrosis Factor-alpha; Tyrphostins

2021
Activation of the spinal EGFR signaling pathway in a rat model of cancer-induced bone pain with morphine tolerance.
    Neuropharmacology, 2021, 09-15, Volume: 196

    Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Cancer Pain; Carcinoma 256, Walker; Drug Tolerance; Enzyme Inhibitors; ErbB Receptors; MAP Kinase Signaling System; Microglia; Morphine; Phosphorylation; Quinazolines; Rats; Spinal Cord; Tibia; Tyrphostins

2021
Morphine Prevents Ischemia/Reperfusion-Induced Myocardial Mitochondrial Damage by Activating δ-opioid Receptor/EGFR/ROS Pathway.
    Cardiovascular drugs and therapy, 2022, Volume: 36, Issue:5

    Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Mitochondria, Heart; Morphine; Myocytes, Cardiac; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Reactive Oxygen Species; Receptors, Opioid; Reperfusion; Reperfusion Injury; RNA, Small Interfering; Superoxides; Tyrphostins

2022
Pulmonary fibrosis distal airway epithelia are dynamically and structurally dysfunctional.
    Nature communications, 2021, 07-27, Volume: 12, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Amphiregulin; Biophysical Phenomena; Epithelium; ErbB Receptors; Fibroblasts; Genetic Predisposition to Disease; Humans; Idiopathic Pulmonary Fibrosis; Keratin-5; Lung; Mucin-5B; Quinazolines; Risk Factors; RNA, Messenger; Signal Transduction; Transcription Factors; Tyrphostins; Verteporfin; YAP-Signaling Proteins

2021
Morphine promotes microglial activation by upregulating the EGFR/ERK signaling pathway.
    PloS one, 2021, Volume: 16, Issue:9

    Topics: Animals; CD11b Antigen; Cell Line; Cell Movement; Drug Tolerance; Enzyme Inhibitors; ErbB Receptors; Gene Expression Regulation; Interleukin-1beta; Mice; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine; Phosphorylation; Quinazolines; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrphostins

2021
Selective therapeutic benefit of X-rays and inhibitors of EGFR, PI3K/mTOR, and Bcl-2 in breast, lung, and cervical cancer cells.
    European journal of pharmacology, 2021, Dec-05, Volume: 912

    Topics: Aniline Compounds; Breast Neoplasms; Cell Line; Cell Survival; ErbB Receptors; Female; Humans; Imidazoles; Lung Neoplasms; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Quinolines; Radiation Tolerance; Sulfonamides; TOR Serine-Threonine Kinases; Tyrphostins; Uterine Cervical Neoplasms; X-Rays

2021
AG1478 Elicits a Novel Anti-Influenza Function via an EGFR-Independent, GBF1-Dependent Pathway.
    International journal of molecular sciences, 2022, May-16, Volume: 23, Issue:10

    Topics: Antiviral Agents; ErbB Receptors; Guanine Nucleotide Exchange Factors; Humans; Influenza, Human; Quinazolines; Signal Transduction; Tyrphostins

2022