rtki cpd has been researched along with epidermal growth factor in 174 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 15 (8.62) | 18.2507 |
| 2000's | 113 (64.94) | 29.6817 |
| 2010's | 43 (24.71) | 24.3611 |
| 2020's | 3 (1.72) | 2.80 |
| Authors | Studies |
|---|---|
| Chelluderai, B; Dutta, S; Fligiel, SE; Jaszewski, R; Majumdar, AP; Tureaud, J | 1 |
| Böhmer, FD; Fernández, LE; Greiser, U; Lage, A; Perez, R; Sánchez, B; Suarez Pestana, E | 1 |
| Klein, JM; McCarthy, TA | 1 |
| Levitzki, A; Osherov, N | 1 |
| Berthelemy, M; Dangles, V; Féménia, F; Lainé, V; Le Rhun, D; Levy, D; Poupon, MF; Schwartz-Cornil, I | 1 |
| Breu, J; Muchnicki, L; Slack, BE; Wurtman, RJ | 1 |
| Higashimoto, Y; Kanayama, S; Kiyohara, T; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Tsutsui, S; Zushi, S | 1 |
| DeWild, LJ; Klein, JM; McCarthy, TA | 1 |
| Soltoff, SP | 1 |
| Dalmau, SR; Freitas, CS; Savino, W | 1 |
| Higashimoto, Y; Kanayama, S; Kiyohara, T; Kondo, S; Matsuzawa, Y; Miyazaki, Y; Shinomura, Y; Sugimachi, M; Zushi, S | 1 |
| Farrell, GC; Zhang, BH | 1 |
| Allal, C; Asslan, R; Favre, G; Le Gaillard, F; Pradines, A; Pratx, C | 1 |
| Gillham, H; Golding, MC; Gullick, WJ; Pepperkok, R | 1 |
| Polk, DB; Tong, W | 1 |
| Ogata, T | 1 |
| Daaka, Y; Lefkowitz, RJ; Luttrell, LM; Maudsley, S; Pierce, KL | 1 |
| Guo, C; Luttrell, LM; Price, DT | 1 |
| Abe, K; Saito, H | 1 |
| Jensen, RL; Petr, M; Wurster, RD | 1 |
| Dorko, K; Esplen, JE; Jo, M; Michalopoulos, GK; Stolz, DB; Strom, SC | 1 |
| Jope, RS; Song, L; Zhang, L | 1 |
| Carpenter, G; Ji, QS | 1 |
| Dalbone, AC; Hutcheon, AE; Takahashi, H; Zieske, JD | 1 |
| Abraham, JA; Clowes, AW; Daum, G; Kalmes, A; Vesti, BR | 1 |
| Bates, SE; Bishop, PC; Blagosklonny, MV; Fojo, T; Robey, R | 1 |
| del Carmen Medina, L; García-Sáinz, JA; Vázquez-Prado, J | 1 |
| Bagnato, A; Catt, KJ; Tecce, R; Vacca, F | 1 |
| Brattain, MG; Jackson, JG; Koterba, AP; Kreisberg, JI; Yee, D | 1 |
| Delouvée, A; el-Marjou, A; Radvanyi, F; Thiery, JP | 1 |
| Fujiyama, S; Higashiyama, S; Iba, O; Iwasaka, T; Jyo, N; Koyama, Y; Maruyama, K; Masaki, H; Matsubara, H; Mori, Y; Nose, A; Nozawa, Y; Ogata, N; Tateishi, E; Tsutsumi, Y; Uchiyama, Y | 1 |
| Berven, LA; Crouch, MF; Davy, DA; Willard, FS | 1 |
| Adrian, TE; Cluck, MW; Knezetic, JA; Larsson, J; Lovas, S; Murphy, LO; Murphy, RF; Otvös, F; Permert, J; Schally, AV | 1 |
| Amir, C; Bowers, G; Dent, P; Hewitt, T; Lammering, G; Mikkelsen, RB; Reardon, D; Schmidt-Ullrich, RK; Valerie, K | 1 |
| Huggett, TM; Jost, M; Kari, C; Rodeck, U | 1 |
| Adachi, H; Fujioka, T; Kim, JH; Saito, K; Tsujimoto, M; Ui, M; Yokoyama, S | 1 |
| Brattain, MG; Ghosh, P; Humphrey, LE; Kreisberg, JI; Sawhney, RS; Zhou, GH | 1 |
| Gildea, JJ; Gulding, KM; Harding, MA; Seraj, MJ; Theodorescu, D | 1 |
| Alberto Olivares-Reyes, J; Catt, KJ; Shah, BH; Yesilkaya, A | 1 |
| Carreras, I; DiCamillo, SJ; Foster, JA; Nugent, MA; Panchenko, MP; Panchenko, MV; Stone, PJ | 1 |
| Chen, MC; Kui, R; Perez Salazar, E; Rozengurt, E; Soll, AH; Solomon, TE | 1 |
| Koty, PP; Lei, W; Levitt, ML | 1 |
| Alonso, A; Dürst, M; Leykauf, K | 1 |
| Collins, JF; Ghishan, FK; Hines, ER; Inouye, M; Xu, H | 1 |
| Dartt, DA; Hodges, RR; Tepavcevic, V; Zoukhri, D | 1 |
| Bringmann, A; Milenkovic, I; Reichenbach, A; Weick, M; Wiedemann, P | 1 |
| Chung, T; Dent, P; Hagan, MP; Hinman, D; McKinstry, R; Yacoub, A | 1 |
| Lorita, J; Pareja, M; Ramírez, I; Sánchez, O; Soley, M | 1 |
| Chan, SY; Mak, KK | 1 |
| Ahmed, I; Drezner, MK; Gesty-Palmer, D; Luttrell, LM | 1 |
| Bernardino, CR; Chang, EL; Dartt, DA; Hodges, RR; Horikawa, Y; Rios, JD; Rubin, PA; Shatos, MA; Zoukhri, D | 1 |
| Amorino, GP; Contessa, JN; Dent, P; Hewit, TH; Lammering, G; Schmidt-Ullrich, RK; Valerie, K | 1 |
| Abbou, CC; Chopin, DK; Daher, A; de Boer, WI; El-Marjou, A; Radvanyi, F; Thiery, JP; van der Kwast, T | 1 |
| Degen, SJ; Hill, KJ; Peace, BE; Waltz, SE | 1 |
| Gui, Y; Zheng, XL | 1 |
| Mattingly, RR; Menard, RE | 1 |
| Ashida, M; Bito, T; Budiyanto, A; Ichihashi, M; Kunisada, M; Ueda, M | 1 |
| González, A; Guerrero, J; Martínez, J; Santibañez, JF | 1 |
| Dowlati, A; Kern, JA; Nethery, D | 1 |
| Rozengurt, E; Santiskulvong, C; Sinnett-Smith, J | 1 |
| Chan, AS; Wong, YH | 1 |
| Prydz, H; Wiiger, MT | 1 |
| Evdonin, AL; Margulis, BA; Medvedeva, ND; Tsupkina, NV | 1 |
| Chen, R; Morinelli, TA; Paul, RV; Ullian, ME; Webb, JG | 1 |
| Kataoka, K; Kurabayashi, T; Kuribayashi, A; Miura, M | 1 |
| Bowling, GH; Khan, SA; Millena, AC; Reddy, SC | 1 |
| Kolachana, P; Lawsin, LM; Moore, J; Perlman, A; Ringel, MD; Saji, M | 1 |
| Abud, HE; Heath, JK; Watson, N | 1 |
| Condeelis, J; Coniglio, S; Eddy, R; Kempiak, S; Lorenz, M; Miki, H; Sarmiento, C; Segall, J; Symons, M; Takenawa, T; Yamaguchi, H | 1 |
| Cheng, J; Chu, EK; Drazen, JM; Foley, JS; Patel, AS; Tschumperlin, DJ | 1 |
| Chen, L; Gao, P; Ma, D; Oppenheim, JJ; Sun, R; Wang, J; Zhang, N | 1 |
| Buck, DC; Macey, TA; Neve, KA; Wang, C; Yang, R | 1 |
| Boulesteix, C; Gall, L; Germain, G; Ruffini, S | 1 |
| Neufeld, AH; Zhang, X | 1 |
| Fujioka, A; Itoh, RE; Kurokawa, K; Matsuda, M; Mayer, BJ; Sharma, A | 1 |
| El Shewy, H; Gesty-Palmer, D; Kohout, TA; Luttrell, LM | 1 |
| Bunting, M; Hanson, BJ; Hanson, GT; O'Grady, M; Raha, D | 1 |
| Kim, HJ; Kim, JH | 1 |
| Cai, K; Enomoto, A; Hosoi, Y; Li, Z; Matsumoto, Y; Miyagawa, K; Morita, A; Nakagawa, K; Tanno, Y | 1 |
| Bolotin, D; Chu, DH; Fuchs, E; Polak, L; Wang, X; Williams, T | 1 |
| Bergmann, S; Henklein, P; Hollenberg, MD; Junker, K; Kaufmann, R; Settmacher, U | 1 |
| Awooda, I; Barhoumi, R; Burghardt, RC; Mouneimne, Y; Safe, S | 1 |
| Angelucci, C; Iacopino, F; Lama, G; Sica, G | 1 |
| Casas-González, P; García-Sáinz, JA | 1 |
| Ashkenazi, H; Cao, X; Motola, S; Popliker, M; Tsafriri, A | 1 |
| Bette, M; Folz, BJ; Mandic, R; Neubauer, A; Rodgarkia-Dara, CJ; Weihe, E; Werner, JA; Zhu, L | 1 |
| Clark, OH; Duh, QY; Park, JW; Rougier, JP; Werb, Z; Wong, M; Yeh, MW | 1 |
| Ibe, BO; Raj, JU; Zhou, W | 1 |
| Daubert, RA; Schnellmann, RG; Yan, Y; Zhuang, S | 1 |
| Patterson, TJ; Rice, RH | 1 |
| Carmona-Cuenca, I; Del Castillo, G; Fabregat, I; Fernández, M; Murillo, MM; Ortiz, C; Roncero, C; Sánchez, A | 1 |
| Ascoli, M; Shiraishi, K | 1 |
| Chen, J; Downs, SM | 1 |
| Koide, M; Penar, PL; Tranmer, BI; Wellman, GC | 1 |
| Guo, J; Sheng, G; Warner, BW | 1 |
| Amraei, MG; Bourret, JC; Brochiero, E; Hijazi, T; Kheir, L; Noël, J; Privé, A; Trinh, NT | 1 |
| Aasrum, M; Christoffersen, T; Dajani, OF; Guren, TK; Lilleby, P; Meisdalen, K; Sandnes, D; Thoresen, GH; Tveteraas, IH | 1 |
| Bhattacharya, S; Johnson, LR; Ray, RM | 1 |
| Kawashima, I; Nishibori, M; Richards, JS; Shimada, M; Yamashita, Y; Yanai, Y | 1 |
| Andresen, BT; Escano, CS; Gutweiler, AA; Keever, LB | 1 |
| Bates, LF; Brackenbury, WJ; Ding, Y; Djamgoz, MB; Montano, X; Onganer, PU; Porter, LM | 1 |
| Chen, DY; Hou, Y; Li, M; Liang, CG; Lin, SL; Schatten, H; Sun, QY; Xiong, B; Xu, BZ | 1 |
| Avissar, NE; Sax, HC; Toia, L | 1 |
| Conti, M; Fu, M; Hsieh, M; Panigone, S; Persani, L | 1 |
| Aoki, H; Ikegame, Y; Inagaki, A; Iwama, T; Kunisada, T; Nakashima, S; Oka, N; Soeda, A; Yoshimura, S | 1 |
| Chen, X; Li, J; Peng, S; Tai, P; Xia, G; Xu, B; Yan, J; Zhang, M; Zhou, B | 1 |
| Amin, DN; Bielenberg, DR; Heymach, JV; Klagsbrun, M; Lifshits, E | 1 |
| Choo, YK; Jin, JW; Jung, JU; Jung, KY; Kim, SM; Ko, K; Ryu, JS; Yang, HJ; You, HK | 1 |
| Barndt, R; Coticchia, CM; Deb, TB; Dickson, RB; Johnson, MD; Zuo, H | 1 |
| Andreau, K; Bailbé, D; Jeulin, C; Marano, F; Seltzer, V | 1 |
| Berg, K; Kaalhus, O; Weyergang, A | 1 |
| Bertran, E; Caja, L; Carmona-Cuenca, I; Fabregat, I; Murillo, MM; Sancho, P | 1 |
| Gleeson, PA; Kerr, MC; Lim, JP; Teasdale, RD; Wang, JT | 1 |
| Hale, J; Irudayaraj, J; Prasad, NK; Ritchie, K; Yu, C | 1 |
| Bierman, A; Hassoun, PM; Reddy, NM; Reddy, SP; Yerrapureddy, A | 1 |
| Akingbemi, BT; Braden, TD; Coleman, ES; Hancock, KD; Kemppainen, BW; Morrison, EE; Tao, YX | 1 |
| Muslimov, GF | 1 |
| Chang, KY; Chang, WC; Chen, BK; Lee, MY; Shen, MR; Su, WC; Wang, WL | 1 |
| Aboulafia, AJ; Cummings, JE; Damron, TA; Joyner, DE; Randall, RL; Trang, SH | 1 |
| Chaffin, CL; Latham, KE; Lee, YS; Nyholt de Prada, JK; VandeVoort, CA | 1 |
| Clowes, AW; Fukai, N; Jalikis, F; Kenagy, RD; Kohler, TR; Min, SK | 1 |
| Ahidouch, A; El Hiani, Y; Lehen'kyi, V; Ouadid-Ahidouch, H | 1 |
| Adam, A; Bouthillier, J; Koumbadinga, GA; Marceau, F; Petitclerc, E | 1 |
| Cho, S; Choe, JH; Choi, JH; Kim, JH; Kim, JS; Kim, S; Kim, WW; Lee, JE; Lee, SK; Lim, HI; Nam, SJ; Yang, JH | 1 |
| Bazzi, H; Christiano, AM; Crawford, H; Fantauzzo, KA; Hynd, P; Jahoda, CA; Richardson, GD; Waters, JM | 1 |
| Cáceres, M; González, MJ; Guerrero, J; Martínez, J; Smith, PC; Tobar, N | 1 |
| Baer, PC; Geiger, H; Schubert, R; Zielen, S | 1 |
| Griffith, LG; Lauffenburger, DA; Platt, MO; Wells, A; Wilder, CL | 1 |
| Buharalioglu, CK; Malik, KU; Mugabe, BE; Song, CY; Waters, CM; Yaghini, FA | 1 |
| Chung, HJ; Gupta, MK; Lee, HT; Min, TS; Uhm, SJ; Yang, JH | 1 |
| Chen, B; Chicoine, LG; Cui, H; Nelin, LD; Toby, IT | 1 |
| Butterworth, RF; Gu, L; Hu, X; Li, B; Li, M; Peng, L; Xue, Z | 1 |
| Chang, KW; Lin, MH; Lin, SC; Miner, JH | 1 |
| Freudzon, M; Jaffe, LA; Nikolaev, VO; Norris, RP | 1 |
| Abd Elmageed, ZY; Amin, AH; Matrougui, K; Partyka, M | 1 |
| Ammer, H; Eisinger, DA | 1 |
| Mandic, R; Meissner, W; Rüddel, J; Wennekes, VE; Werner, JA | 1 |
| Boarder, MR; Cheng, Z; Dixon, CJ; Hall, JF; Luo, Y; Taylor, E | 1 |
| Chaudhari, N; Kharmate, G; Kumar, U; Qiu, X; Rajput, PS; Somvanshi, RK; Watt, HL | 1 |
| Camaioni, A; Mlynarcikova, A; Nagyova, E; Nemcova, L; Prochazka, R; Salustri, A; Scsukova, S | 1 |
| Aoki, S; Hamasaki, Y; Izuhara, K; Taniguchi, K; Toda, S; Yamamoto, S | 1 |
| Arnold, W; Beck, C; Boulesteix, AL; Knopf, A; Margraf, J; Pickhard, AC; Pigorsch, S; Piontek, G; Reiter, R; Scherer, EQ; Schlegel, J; Stark, T | 1 |
| Jia, YD; Lin, JX; Zhang, CQ | 1 |
| Brännström, M; Curry, TE; Li, F; McCord, LA; Rosewell, KL | 1 |
| Gashaw, I; Klein, R; Stiller, S | 1 |
| Carpenter, G; Liao, HJ | 1 |
| Ikari, A; Sato, T; Sugatani, J; Watanabe, R; Yamazaki, Y | 1 |
| Barbieri, MA; Jozic, I; Saliba, SC | 1 |
| Chang, LS; Chiu, CC; Hsieh, CY; Lin, SR; Tsai, PC; Wang, CK | 1 |
| Cebrián-Pérez, JA; Colás, C; Luna, C; Muiño-Blanco, T; Pérez-Pé, R | 1 |
| Jiang, Y; Lu, F; Sun, X; Wang, F; Wang, W; Xu, S; Zhang, L | 1 |
| Carson, DD; Engel, BJ | 1 |
| Gao, FH; Guo, YH; Jiang, B; Shi, J; Yuan, HH | 1 |
| Cho-Clark, M; Larco, DO; Mani, SK; Semsarzadeh, NN; Vasta, F; Wu, TJ | 1 |
| Borgmann, D; Höglinger, O; Lanzerstorfer, P; Schütz, G; Weghuber, J; Winkler, SM | 1 |
| Han, D; Sun, J; Wang, F; Xiao, W; Zhu, Y | 1 |
| Beaty, BT; Condeelis, JS; Cox, D; Eddy, RJ; Sharma, VP | 1 |
| Bailie, K; Bell, J; Comer, D; Douglas, I; Heaney, LG; Parker, JC; Shields, MD; Skibinski, G | 1 |
| Li, CY; Li, X; Liu, JL; Qu, WS; Tian, DS; Wang, W; Xie, MJ | 1 |
| Li, X; Liang, G; Liu, Z; Peng, K; Qian, Y; Skibba, M; Tian, X; Wang, J; Xu, Z; Zou, C | 1 |
| Sui, JQ; Xie, KP; Xie, MJ | 1 |
| Ma, Y; Shi, H; Yi, Y; Zhang, T | 1 |
| Fujimoto, M; Imanaka-Yoshida, K; Kawakita, F; Liu, L; Nakasaki, A; Shiba, M; Shimojo, N; Suzuki, H; Yoshida, T | 1 |
| Heath, JK; Pike, JA; Rappoport, JZ; Styles, IB | 1 |
| Nakajima, M; Nozaki, M; Ohnishi, Y; Yasui, H | 1 |
| Araldi, D; Ferrari, LF; Levine, JD | 1 |
| Araujo Vieira, I; Brufatto Olguins, D; Brunetto de Farias, C; José Gregianin, L; Kersting, N; Kunzler Souza, B; Lunardi Brunetto, A; Pereira Dos Santos, R; Roesler, R; Schwartsmann, G; Tesainer Brunetto, A | 1 |
| Gao, MY; Lin, C; Qin, Y; Wang, YF; Zhang, H | 1 |
| Akin, JW; Brännström, M; Choi, Y; Curry, TE; Jo, M; Rosewell, KL | 1 |
| Li, J; Liu, Y; Lu, J; Peng, Z; Zhang, L | 1 |
| Barros Nunes, G; Chediek Dall'Acqua, P; Fábio Gouveia Nogueira, M; Fontes, PK; Lombardi Lopes, F; Marinho, M; Rodrigues da Silva, C; Zoccal Mingoti, G | 1 |
| Bian, X; Li, X; Sun, Y; Tian, W; Tian, Y; Xu, J; Zhao, H | 1 |
| Arai, W; Chiba, H; Kodera, Y; Kohno, T; Kojima, T; Konno, T; Miyajima, M; Sakuma, Y; Shindo, Y; Tsujiwaki, M; Watanabe, A | 1 |
| Kanamaru, H; Kawakita, F; Liu, L; Nakano, F; Nakatsuka, Y; Nishikawa, H; Okada, T; Suzuki, H | 1 |
1 review(s) available for rtki cpd and epidermal growth factor
| Article | Year |
|---|---|
The relative role of ErbB1-4 receptor tyrosine kinases in radiation signal transduction responses of human carcinoma cells.
Topics: Autocrine Communication; Benzothiazoles; Breast Neoplasms; Carcinoma; Epidermal Growth Factor; ErbB Receptors; Female; Genes, erbB; Growth Substances; Humans; Neuregulin-1; Quinazolines; Radiation, Ionizing; Receptor Protein-Tyrosine Kinases; Receptor, ErbB-2; Receptor, ErbB-3; Receptor, ErbB-4; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2001 |
173 other study(ies) available for rtki cpd and epidermal growth factor
| Article | Year |
|---|---|
Inhibition of gastric mucosal regeneration by tyrphostin: evaluation of the role of epidermal growth factor receptor tyrosine kinase.
Topics: Animals; Benzylidene Compounds; Epidermal Growth Factor; Gene Expression Regulation, Enzymologic; Male; Mucous Membrane; Nitriles; Proliferating Cell Nuclear Antigen; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Inbred F344; Regeneration; Stomach; Tyrphostins | 1996 |
Growth inhibition of human lung adenocarcinoma cells by antibodies against epidermal growth factor receptor and by ganglioside GM3: involvement of receptor-directed protein tyrosine phosphatase(s).
Topics: Adenocarcinoma; Benzylidene Compounds; Carcinoma, Non-Small-Cell Lung; Cell Division; Cell Membrane; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Humans; Lung Neoplasms; Nitriles; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Radioligand Assay; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1997 |
Inhibition of tyrosine kinase activity decreases expression of surfactant protein A in a human lung adenocarcinoma cell line independent of epidermal growth factor receptor.
Topics: Benzylidene Compounds; Binding, Competitive; Blotting, Northern; Blotting, Western; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Lung; Lung Neoplasms; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinazolines; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins | 1997 |
Tyrphostin AG 494 blocks Cdk2 activation.
Topics: 3T3 Cells; Acrylamides; Animals; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Mice; Molecular Structure; Nitriles; Protein Serine-Threonine Kinases; Quinazolines; Tyrphostins | 1997 |
Two- and three-dimensional cell structures govern epidermal growth factor survival function in human bladder carcinoma cell lines.
Topics: Apoptosis; Culture Media, Serum-Free; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Epidermal Growth Factor; ErbB Receptors; Genistein; Humans; Isoflavones; Neoplasm Proteins; Nitriles; Protein-Tyrosine Kinases; Quinazolines; Spheroids, Cellular; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation; Urinary Bladder Neoplasms | 1997 |
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Androstadienes; Aspartic Acid Endopeptidases; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Inositol; Inositol Phosphates; Maleimides; Nitriles; Phosphatidylinositols; Phosphotyrosine; Protein Kinase C; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Wortmannin | 1997 |
Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activated ras-stimulated intestinal epithelial cells.
Topics: Amphiregulin; Animals; Apoptosis; Autocrine Communication; Betacellulin; Cell Division; Cells, Cultured; Chlorates; Culture Media, Conditioned; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Nitriles; Phosphorylation; Polysaccharide-Lyases; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; ras Proteins; Rats; RNA; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins; Up-Regulation | 1997 |
Effect of tyrosine kinase inhibition on surfactant protein A gene expression during human lung development.
Topics: Embryonic and Fetal Development; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genistein; Homeostasis; Humans; Lung; Nitriles; Phosphorylation; Protein-Tyrosine Kinases; Proteolipids; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Proteins; Pulmonary Surfactants; Quinazolines; RNA, Messenger; Tyrosine; Tyrphostins | 1998 |
Related adhesion focal tyrosine kinase and the epidermal growth factor receptor mediate the stimulation of mitogen-activated protein kinase by the G-protein-coupled P2Y2 receptor. Phorbol ester or [Ca2+]i elevation can substitute for receptor activation.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Focal Adhesion Kinase 2; GTP-Binding Proteins; Ionomycin; Models, Biological; Nitriles; PC12 Cells; Phorbol Esters; Phosphorylation; Protein-Tyrosine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Quinazolines; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2Y2; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrosine; Tyrphostins; Ubiquitin-Protein Ligases; Uridine Triphosphate | 1998 |
Epidermal growth factor (EGF) modulates fetal thymocyte growth and differentiation: partial reversal by insulin, mimicking by specific inhibitors of EGF receptor tyrosine kinase activity, and differential expression of CD45 phosphatase isotypes.
Topics: Animals; Cell Differentiation; Cell Division; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fetus; Growth Inhibitors; Immunophenotyping; Insulin; Isoenzymes; Leukocyte Common Antigens; Mice; Mice, Inbred C57BL; Molecular Mimicry; Nitriles; Organ Culture Techniques; Quinazolines; Solubility; T-Lymphocyte Subsets; Thymus Gland; Tyrphostins | 1998 |
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells.
Topics: Acute-Phase Proteins; Animals; bcl-X Protein; Cell Line; Cell Survival; Cell Transformation, Neoplastic; DNA Fragmentation; DNA-Binding Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Genes, ras; Intestinal Mucosa; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Rats; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrphostins | 1998 |
Chronic ethanol consumption disrupts complexation between EGF receptor and phospholipase C-gamma1: relevance to impaired hepatocyte proliferation.
Topics: Animals; Calcium Signaling; Cell Division; Cells, Cultured; Cytoskeleton; Cytosol; DNA; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Ethanol; Isoenzymes; Liver; Male; Phospholipase C gamma; Phosphorylation; Phosphotyrosine; Protein Binding; Quinazolines; Rats; Rats, Wistar; Type C Phospholipases; Tyrphostins | 1999 |
Epidermal growth factor stimulates 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression via the ErbB-2 pathway in human breast adenocarcinoma cells.
Topics: Adenocarcinoma; Breast Neoplasms; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Receptor, ErbB-2; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 1999 |
Intracellular movement of green fluorescent protein-tagged phosphatidylinositol 3-kinase in response to growth factor receptor signaling.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane; Chromones; Cytochalasin D; Cytoplasm; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; Humans; Luminescent Proteins; Mice; Microscopy, Fluorescence; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Quinazolines; Receptor, ErbB-3; Recombinant Fusion Proteins; Signal Transduction; src Homology Domains; Transfection; Tyrphostins | 1999 |
Epidermal and hepatocyte growth factors stimulate chemotaxis in an intestinal epithelial cell line.
Topics: Animals; Cell Division; Cell Line, Transformed; Chemotaxis; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Matrix; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Flavonoids; Genistein; Growth Substances; Hepatocyte Growth Factor; Insulin-Like Growth Factor I; Intestines; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Naphthalenes; Quinazolines; Transforming Growth Factor beta; Type C Phospholipases; Tyrphostins | 1999 |
Fluid flow-induced tyrosine phosphorylation and participation of growth factor signaling pathway in osteoblast-like cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blotting, Western; Cell Line; Culture Media; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; Gene Expression Regulation; Immediate-Early Proteins; Mice; Mitogen-Activated Protein Kinase 1; Osteoblasts; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein-Tyrosine Kinases; Proteins; Quinazolines; RNA, Messenger; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Stress, Mechanical; Transcription Factors; Tyrosine; Tyrphostins | 2000 |
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.
Topics: Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Clathrin; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique; GTP-Binding Proteins; Isoproterenol; Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Cell Surface; Transfection; Tyrphostins | 2000 |
Mitogenic signaling in androgen sensitive and insensitive prostate cancer cell lines.
Topics: Cell Division; Dihydrotestosterone; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Humans; Male; Mitogen-Activated Protein Kinases; Phosphorylation; Prostatic Neoplasms; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2000 |
The mitogen-activated protein kinase cascade mediates neurotrophic effect of epidermal growth factor in cultured rat hippocampal neurons.
Topics: Animals; Blotting, Western; Butadienes; Cell Survival; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Epidermal Growth Factor; Flavonoids; Hippocampus; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neurons; Nitriles; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Tyrphostins | 2000 |
Calcium channel antagonist effect on in vitro meningioma signal transduction pathways after growth factor stimulation.
Topics: Adult; Aged; Blood Physiological Phenomena; Calcium; Calcium Channel Blockers; Culture Techniques; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Female; Growth Substances; Humans; Inositol Phosphates; Intracellular Membranes; Male; Meningeal Neoplasms; Meningioma; Middle Aged; Quinazolines; Signal Transduction; Type C Phospholipases; Tyrphostins | 2000 |
Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells.
Topics: Animals; Carcinoma, Hepatocellular; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Liver Neoplasms; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-met; Quinazolines; Rats; Receptor Cross-Talk; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 2000 |
Peroxynitrite modulates the activation of p38 and extracellular regulated kinases in PC12 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Nitrates; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Phosphorylation; Quinazolines; Rats; src-Family Kinases; Tyrphostins | 2000 |
Role of basal calcium in the EGF activation of MAP kinases.
Topics: Animals; Calcium; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Isoenzymes; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phospholipase C gamma; Protein Tyrosine Phosphatases; Quinazolines; Type C Phospholipases; Tyrphostins | 2000 |
Activation of epidermal growth factor receptor during corneal epithelial migration.
Topics: Amphiregulin; Animals; Binding Sites; Cell Movement; Debridement; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium, Corneal; ErbB Receptors; Female; Fluorescent Antibody Technique, Indirect; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Organ Culture Techniques; Phosphorylation; Precipitin Tests; Quinazolines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrphostins; Wound Healing | 2000 |
Heparin blockade of thrombin-induced smooth muscle cell migration involves inhibition of epidermal growth factor (EGF) receptor transactivation by heparin-binding EGF-like growth factor.
Topics: Animals; Anticoagulants; Aorta; Becaplermin; Cell Line; Cell Movement; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; Papio; Phenylalanine; Phosphorylation; Platelet-Derived Growth Factor; Protease Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Rats; Rats, Inbred F344; Signal Transduction; Thiophenes; Thrombin; Tyrphostins | 2000 |
Loss of cell cycle control allows selective microtubule-active drug-induced Bcl-2 phosphorylation and cytotoxicity in autonomous cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Division; Cell Survival; Enzyme Inhibitors; Epidermal Growth Factor; Female; HL-60 Cells; Humans; Microtubules; Mitosis; Paclitaxel; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tetradecanoylphorbol Acetate; Tubulin; Tumor Cells, Cultured; Tyrphostins | 2000 |
Cross-talk between receptors with intrinsic tyrosine kinase activity and alpha1b-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Cell Line; Cell Membrane; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Fibroblasts; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Norepinephrine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet-Derived Growth Factor; Protein Binding; Protein Kinase C; Protein-Tyrosine Kinases; Quinazolines; Rats; Receptor Protein-Tyrosine Kinases; Receptors, Adrenergic, alpha-1; Staurosporine; Time Factors; Transfection; Tyrphostins; Wortmannin | 2000 |
Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Cell Division; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; GRB2 Adaptor Protein; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Ovarian Neoplasms; Peptides, Cyclic; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Proteins; Quinazolines; Receptor, Endothelin A; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transcriptional Activation; Tumor Cells, Cultured; Tyrosine; Tyrphostins | 2000 |
Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells.
Topics: Alkaline Phosphatase; Biological Transport; Breast Neoplasms; Cell Nucleus; Chromones; Cytoplasm; DNA-Binding Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Humans; Macromolecular Substances; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-cbl; Quinazolines; Signal Transduction; Transcription Factors; Tumor Cells, Cultured; Tyrphostins; Ubiquitin-Protein Ligases | 2000 |
Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression.
Topics: Amphiregulin; Animals; Betacellulin; Butylhydroxybutylnitrosamine; Carcinogens; Disease Progression; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glycoproteins; Growth Substances; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Kidney; Kidney Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic; Tyrphostins | 2000 |
Angiotensin AT(1) and AT(2) receptors differentially regulate angiopoietin-2 and vascular endothelial growth factor expression and angiogenesis by modulating heparin binding-epidermal growth factor (EGF)-mediated EGF receptor transactivation.
Topics: Angiopoietin-1; Angiopoietin-2; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Calcium; Cells, Cultured; Cornea; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Heparin-binding EGF-like Growth Factor; Imidazoles; In Vitro Techniques; Indoles; Intercellular Signaling Peptides and Proteins; Lymphokines; Maleimides; Membrane Glycoproteins; Naphthalenes; Neovascularization, Physiologic; Olmesartan Medoxomil; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proteins; Pyridines; Quinazolines; Rabbits; Rats; Receptor Protein-Tyrosine Kinases; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, TIE-2; Receptors, Angiotensin; Receptors, Cell Surface; Receptors, TIE; RNA Stability; RNA, Messenger; Tetrazoles; Time Factors; Transcriptional Activation; Tyrphostins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Activation of endogenous thrombin receptors causes clustering and sensitization of epidermal growth factor receptors of swiss 3T3 cells without transactivation.
Topics: 3T3 Cells; Animals; Cell Division; Cell Movement; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Green Fluorescent Proteins; GTP-Binding Proteins; Luminescent Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phalloidine; Quinazolines; Receptor Cross-Talk; Receptors, Thrombin; Recombinant Proteins; Ribosomal Protein S6 Kinases; Signal Transduction; Thrombin; Transfection; Tyrphostins | 2001 |
Pancreatic cancer cells require an EGF receptor-mediated autocrine pathway for proliferation in serum-free conditions.
Topics: Cell Division; Culture Media, Serum-Free; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gastrin-Releasing Peptide; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pancreatic Neoplasms; Quinazolines; Substrate Specificity; Transcription Factor AP-1; Tumor Cells, Cultured; Tyrphostins | 2001 |
Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway.
Topics: bcl-X Protein; Calcium-Calmodulin-Dependent Protein Kinases; Caspase Inhibitors; Caspases; Cell Survival; Cells, Cultured; Chromones; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Flavonoids; Humans; In Situ Nick-End Labeling; Keratinocytes; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Morpholines; Oligopeptides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Quinazolines; Tyrphostins | 2001 |
Further evidence for the involvement of insulin receptor substrates in epidermal growth factor-induced activation of phosphatidylinositol 3-kinase.
Topics: Androstadienes; Animals; Cell-Free System; CHO Cells; Cricetinae; DNA, Complementary; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Plasmids; Precipitin Tests; Protein Structure, Tertiary; Quinazolines; Receptor, Insulin; Signal Transduction; Time Factors; Transfection; Tumor Cells, Cultured; Tyrosine; Tyrphostins; Wortmannin | 2001 |
Differences in sensitivity of biological functions mediated by epidermal growth factor receptor activation with respect to endogenous and exogenous ligands.
Topics: Antigens, CD; Cell Adhesion; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix Proteins; Humans; Integrin alpha2; Ligands; Quinazolines; RNA, Messenger; Transfection; Transforming Growth Factor alpha; Tumor Cells, Cultured; Tyrphostins | 2002 |
The role of Ral A in epidermal growth factor receptor-regulated cell motility.
Topics: Animals; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Mice; Neoplasm Metastasis; Quinazolines; ral GTP-Binding Proteins; Tumor Cells, Cultured; Tyrphostins; Urinary Bladder Neoplasms | 2002 |
Independence of angiotensin II-induced MAP kinase activation from angiotensin type 1 receptor internalization in clone 9 hepatocytes.
Topics: Angiotensin II; Animals; Arsenicals; Cell Line; Concanavalin A; COS Cells; Endocytosis; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Hepatocytes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Quinazolines; Rats; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Sucrose; Transfection; Tyrphostins | 2002 |
Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts.
Topics: Animals; Down-Regulation; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Humans; Leukocyte Elastase; Lung; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Tropoelastin; Tyrphostins | 2002 |
Secretin regulates paracellular permeability in canine gastric monolayers by a Src kinase-dependent pathway.
Topics: Animals; Cell Membrane Permeability; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Electric Impedance; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Gastric Mucosa; Mannitol; Parietal Cells, Gastric; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Quinazolines; Secretin; src-Family Kinases; Tyrphostins | 2002 |
Relationship of EGFR signal-transduction modulation by tyrosine kinase inhibitors to chemosensitivity and programmed cell death in lung cancer cell lines.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Lung Neoplasms; Phosphorylation; Precipitin Tests; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Tumor Cells, Cultured; Tyrphostins | 2003 |
Phosphorylation and subcellular distribution of connexin43 in normal and stressed cells.
Topics: Animals; Anisomycin; Antibody Specificity; Cell Membrane; Cells, Cultured; Connexin 43; Cytoplasm; Diuretics, Osmotic; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; Flavonoids; Fluorescent Antibody Technique; Liver; Microscopy, Confocal; Osmotic Pressure; Phosphorylation; Protein Synthesis Inhibitors; Quinazolines; Rabbits; Rats; Sorbitol; Tyrphostins | 2003 |
Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb.
Topics: Base Sequence; Blotting, Western; Caco-2 Cells; DNA; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Molecular Sequence Data; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Proto-Oncogene Proteins c-myb; Quinazolines; Signal Transduction; Sodium-Phosphate Cotransporter Proteins; Sodium-Phosphate Cotransporter Proteins, Type IIb; Symporters; Transcription, Genetic; Tyrphostins | 2003 |
Signal transduction pathways used by EGF to stimulate protein secretion in rat lacrimal gland.
Topics: Animals; Blotting, Western; Calcium; Carbachol; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Eye Proteins; Lacrimal Apparatus; Male; Peroxidase; Phenylephrine; Phospholipase C gamma; Phosphorylation; Protein Kinase C; Quinazolines; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Type C Phospholipases; Tyrphostins | 2003 |
P2Y receptor-mediated stimulation of Müller glial cell DNA synthesis: dependence on EGF and PDGF receptor transactivation.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Cell Division; Cells, Cultured; DNA; DNA Replication; Epidermal Growth Factor; ErbB Receptors; Guinea Pigs; Matrix Metalloproteinase Inhibitors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neuroglia; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet-Derived Growth Factor; Quinazolines; Receptors, Platelet-Derived Growth Factor; Receptors, Purinergic P2; Tyrphostins | 2003 |
Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in DU145 and LNCaP prostate carcinoma through MAPK signaling.
Topics: Adenocarcinoma; Autocrine Communication; Cobalt Radioisotopes; DNA Damage; DNA Repair; DNA-Binding Proteins; Endonucleases; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Prostatic Neoplasms; Protein Biosynthesis; Proteins; Quinazolines; Tumor Cells, Cultured; Tyrphostins; X-ray Repair Cross Complementing Protein 1 | 2003 |
Activated epidermal growth factor receptor (ErbB1) protects the heart against stress-induced injury in mice.
Topics: Aggression; Animals; Behavior, Animal; Cold Temperature; Epidermal Growth Factor; ErbB Receptors; Heart; Male; Mice; Myocardium; Quinazolines; Restraint, Physical; Stress, Physiological; Tyrphostins | 2003 |
Epidermal growth factor as a biologic switch in hair growth cycle.
Topics: Animals; Cell Division; Dimerization; Epidermal Growth Factor; Hair; Hair Follicle; Heterozygote; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Ligands; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Biological; Phenotype; Phosphorylation; Precipitin Tests; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Skin Physiological Phenomena; Time Factors; Tyrphostins | 2003 |
Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.
Topics: Animals; Cell Differentiation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Dinoprost; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Lysophospholipids; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Osteoblasts; Parathyroid Hormone; Phosphorylation; Protein Kinase C; Quinazolines; Rats; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Receptors, Prostaglandin; Signal Transduction; Transcriptional Activation; Tyrphostins | 2003 |
Activation of mitogen-activated protein kinase by cholinergic agonists and EGF in human compared with rat cultured conjunctival goblet cells.
Topics: Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Carbachol; Cells, Cultured; Cholinergic Agonists; Conjunctiva; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Goblet Cells; Humans; Male; Middle Aged; Mitogen-Activated Protein Kinases; Muscarinic Antagonists; Piperidines; Quinazolines; Rats; Rats, Sprague-Dawley; Time Factors; Tyrphostins | 2003 |
EGFRvIII-mediated radioresistance through a strong cytoprotective response.
Topics: Animals; Apoptosis; CHO Cells; Cricetinae; Cytoprotection; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Radiation Tolerance; Tyrphostins | 2003 |
Epidermal growth factor receptor regulates normal urothelial regeneration.
Topics: Amphiregulin; Antibodies, Blocking; Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Movement; Cells, Cultured; DNA Primers; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Quinazolines; Regeneration; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Transforming Growth Factor alpha; Tyrphostins; Urothelium; Wound Healing | 2003 |
Cross-talk between the receptor tyrosine kinases Ron and epidermal growth factor receptor.
Topics: 3T3 Cells; Animals; Cell Communication; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Hepatocyte Growth Factor; Humans; Kidney; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins; Quinazolines; Receptor Cross-Talk; Receptor Protein-Tyrosine Kinases; Signal Transduction; Transfection; Tyrphostins | 2003 |
Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway.
Topics: Animals; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Cycle Proteins; Cell Division; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Humans; Male; MAP Kinase Signaling System; Microscopy, Confocal; Muscle, Smooth, Vascular; Phenotype; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; S Phase; Time Factors; Tumor Suppressor Proteins; Tyrphostins | 2003 |
Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways.
Topics: Androstadienes; Animals; Carbachol; cdc42 GTP-Binding Protein; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Kinetics; Lysophospholipids; Maleimides; Mice; Models, Biological; Myelin Basic Protein; NIH 3T3 Cells; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Quinazolines; rac GTP-Binding Proteins; ras Proteins; Receptor, Muscarinic M2; Receptors, Cell Surface; rho GTP-Binding Proteins; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tyrphostins; Wortmannin | 2003 |
Inhibition of the epidermal growth factor receptor suppresses telomerase activity in HSC-1 human cutaneous squamous cell carcinoma cells.
Topics: Carcinoma, Squamous Cell; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Mitogen-Activated Protein Kinases; Nuclear Proteins; Phosphoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Quinazolines; Repressor Proteins; RNA, Messenger; Skin Neoplasms; Telomerase; Transforming Growth Factor alpha; Tyrphostins | 2003 |
EGF receptor transactivation by urokinase receptor stimulus through a mechanism involving Src and matrix metalloproteinases.
Topics: Adenocarcinoma; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Epidermal Growth Factor; ErbB Receptors; Female; Genes, src; Humans; Kinetics; Matrix Metalloproteinases; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; Peptide Fragments; Phosphorylation; Quinazolines; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Transcriptional Activation; Tyrphostins; Urokinase-Type Plasminogen Activator | 2004 |
Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy.
Topics: Antibodies, Monoclonal; Cell Division; Cell Line, Tumor; DNA-Binding Proteins; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Inhibitory Concentration 50; Phosphorylation; Quinazolines; Receptor, ErbB-2; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrphostins | 2004 |
Insulin reduces the requirement for EGFR transactivation in bombesin-induced DNA synthesis.
Topics: Animals; Bombesin; DNA; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Insulin; Mice; Protein Tyrosine Phosphatases; Quinazolines; Swiss 3T3 Cells; Thymidine; Transcriptional Activation; Tritium; Tyrphostins | 2004 |
Epidermal growth factor differentially augments G(i)-mediated stimulation of c-Jun N-terminal kinase activity.
Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Chlorocebus aethiops; COS Cells; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gi-Go; Hong Kong; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-jun; Quinazolines; Receptors, G-Protein-Coupled; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; src-Family Kinases; Type C Phospholipases; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2 | 2004 |
The epidermal growth factor receptor (EGFR) and proline rich tyrosine kinase 2 (PYK2) are involved in tissue factor dependent factor VIIa signalling in HaCaT cells.
Topics: Binding Sites; Cell Line; DNA-Binding Proteins; Early Growth Response Protein 1; Epidermal Growth Factor; ErbB Receptors; Factor VIIa; Focal Adhesion Kinase 2; Heparin-binding EGF-like Growth Factor; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Interleukin-8; Keratinocytes; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Recombinant Proteins; RNA, Messenger; Signal Transduction; Thromboplastin; Transcription Factors; Tyrphostins | 2004 |
[Effect of EGF on the intracellular distribution of heat-shock proteins in A431 cells].
Topics: Antibodies, Monoclonal; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Estrenes; Fluorescent Antibody Technique; Heat-Shock Proteins; Hot Temperature; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Phosphorylation; Protein-Tyrosine Kinases; Pyrrolidinones; Quinazolines; Time Factors; Type C Phospholipases; Tyrphostins; Vanadates | 2003 |
Mechanisms of vascular angiotensin II surface receptor regulation by epidermal growth factor.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Cells, Cultured; Cytochalasin D; Dactinomycin; Down-Regulation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Ligands; Muscle, Smooth, Vascular; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Tyrphostins | 2004 |
Evidence that basal activity, but not transactivation, of the epidermal growth factor receptor tyrosine kinase is required for insulin-like growth factor I-induced activation of extracellular signal-regulated kinase in oral carcinoma cells.
Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; Heparin-binding EGF-like Growth Factor; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinases; Mouth Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Quinazolines; ras Proteins; Receptor Cross-Talk; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Tyrphostins | 2004 |
Autocrine regulation of steroidogenic function of Leydig cells by transforming growth factor-alpha.
Topics: Androgens; Animals; Autocrine Communication; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gene Expression Regulation; Isoquinolines; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinases; Phosphoproteins; Quinazolines; Rats; RNA, Messenger; Steroids; Sulfonamides; Transforming Growth Factor alpha; Tyrphostins | 2004 |
Angiotensin II regulation of TGF-beta in murine mesangial cells involves both PI3 kinase and MAP kinase.
Topics: Angiotensin II; Animals; Butadienes; Cell Line; Chromones; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Glomerular Mesangium; Immunoblotting; Losartan; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta; Tyrphostins | 2004 |
Growth of intestinal epithelium in organ culture is dependent on EGF signalling.
Topics: Animals; Apoptosis; Body Patterning; Cell Proliferation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelium; ErbB Receptors; Female; Intestines; Mice; Mice, Inbred ICR; Organ Culture Techniques; Pregnancy; Quinazolines; Signal Transduction; Tyrphostins | 2005 |
Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin.
Topics: Actin Depolymerizing Factors; Actin-Related Protein 2; Actin-Related Protein 3; Actins; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; cdc42 GTP-Binding Protein; Cell Line, Tumor; Cell Movement; Cell Surface Extensions; Cytoskeletal Proteins; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Matrix; Fibronectins; GRB2 Adaptor Protein; Microfilament Proteins; Microscopy, Fluorescence; Models, Biological; Neoplasm Invasiveness; Nerve Tissue Proteins; Oncogene Proteins; Quinazolines; Rats; RNA, Small Interfering; Transfection; Tyrphostins; Wiskott-Aldrich Syndrome Protein Family; Wiskott-Aldrich Syndrome Protein, Neuronal | 2005 |
Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner.
Topics: Amphiregulin; Autocrine Communication; Bronchi; Cells, Cultured; Compressive Strength; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Gene Expression Regulation; Glycoproteins; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Quinazolines; Respiratory Mucosa; Signal Transduction; Stress, Mechanical; Time Factors; Tyrphostins | 2005 |
Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.
Topics: Alkaloids; Benzophenanthridines; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Chemokines, CXC; Chemotaxis; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Morpholines; Phenanthridines; Protein Kinase C; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2005 |
Dopamine D2 receptor stimulation of mitogen-activated protein kinases mediated by cell type-dependent transactivation of receptor tyrosine kinases.
Topics: Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Genetic Vectors; Humans; Indole Alkaloids; Microscopy, Confocal; Neuroblastoma; Piperazines; Platelet-Derived Growth Factor; Quinazolines; Quinpirole; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor Protein-Tyrosine Kinases; Receptors, Dopamine D2; Simplexvirus; Spiperone; Transcriptional Activation; Transfection; Tritium; Tyrphostins | 2005 |
EGF-induced EGF-receptor and MAP kinase phosphorylation in goat cumulus cells during in vitro maturation.
Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Female; Flavonoids; Goats; Immunoassay; MAP Kinase Kinase Kinases; Mitogen-Activated Protein Kinases; Ovarian Follicle; Phosphorylation; Quinazolines; Time Factors; Tyrphostins | 2005 |
Activation of the epidermal growth factor receptor in optic nerve astrocytes leads to early and transient induction of cyclooxygenase-2.
Topics: Animals; Astrocytes; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor; ErbB Receptors; Fluorescent Antibody Technique, Indirect; Nitrobenzenes; Optic Nerve; Optic Nerve Injuries; Prostaglandin-Endoperoxide Synthases; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Wistar; Sulfonamides; Tyrphostins | 2005 |
A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes.
Topics: Animals; Antibodies, Monoclonal; Chlorocebus aethiops; COS Cells; Endocytosis; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fluorescence Recovery After Photobleaching; Fluorescence Resonance Energy Transfer; HeLa Cells; Humans; Immunoblotting; Kinetics; Microscopy, Video; Molecular Probes; Phosphorylation; Precipitin Tests; Protein Binding; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Quinazolines; Tyrosine; Tyrphostins | 2005 |
beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.
Topics: Animals; Arrestins; beta-Arrestin 1; beta-Arrestin 2; beta-Arrestins; Cells, Cultured; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; Epitopes; ErbB Receptors; Fibroblasts; Flavonoids; Gene Expression Regulation; Humans; Lysophospholipids; Mice; Mice, Knockout; Microscopy, Confocal; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Models, Biological; Phosphorylation; Quinazolines; ras Proteins; RNA; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrphostins | 2005 |
Combining RNA interference and kinase inhibitors against cell signalling components involved in cancer.
Topics: Antibodies, Monoclonal; beta-Lactamases; Butadienes; Cell Differentiation; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Immunohistochemistry; Inhibitory Concentration 50; MAP Kinase Kinase 1; Neoplasms; Nitriles; Oligonucleotides, Antisense; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transfection; Tyrphostins | 2005 |
Direct involvement of G protein alpha(q/11) subunit in regulation of muscarinic receptor-mediated sAPPalpha release.
Topics: Amino Acid Sequence; Cell Line, Tumor; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Molecular Sequence Data; Muscarinic Agonists; Quinazolines; Receptor Cross-Talk; Receptor, Muscarinic M3; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Serum Amyloid A Protein; Transfection; Tyrphostins | 2005 |
Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.
Topics: Androstadienes; Cell Line, Tumor; Cells, Cultured; Dose-Response Relationship, Radiation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Humans; Immunoblotting; Immunoprecipitation; Infrared Rays; Intracellular Signaling Peptides and Proteins; Kinetics; Ligands; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Pyrimidines; Quinazolines; Radiation, Ionizing; Signal Transduction; src-Family Kinases; Temperature; Time Factors; Transcriptional Activation; Tyrosine; Tyrphostins; Wortmannin; X-Rays | 2006 |
AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis.
Topics: Animals; Animals, Newborn; Calcium; Caspase 3; Caspases; Cell Proliferation; Chromatin Immunoprecipitation; Chromones; Dermis; DNA; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Gene Expression; Gene Expression Regulation; Hair Diseases; Integrases; Keratinocytes; Keratins; Ki-67 Antigen; MAP Kinase Signaling System; Mice; Mice, Transgenic; Morpholines; Phosphorylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Skin; Skin Abnormalities; Tetradecanoylphorbol Acetate; Transcription Factor AP-2; Transforming Growth Factor alpha; Tyrphostins | 2006 |
PAR-type thrombin receptors in renal carcinoma cells: PAR1-mediated EGFR activation promotes cell migration.
Topics: Cell Line, Tumor; Cell Movement; Dipeptides; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Kidney Neoplasms; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Oligopeptides; Phosphorylation; Pyrroles; Quinazolines; Receptor, PAR-1; Thrombin; Tyrosine; Tyrphostins | 2006 |
Effects of benzo-a-pyrene on oxytocin-induced Ca2+ oscillations in myometrial cells.
Topics: Adult; Benzo(a)pyrene; Calcium; Calcium Signaling; Carcinogens, Environmental; Cells, Cultured; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Enzyme Inhibitors; Epidermal Growth Factor; Female; Genistein; Humans; Myometrium; Oxytocin; Pregnancy; Protein-Tyrosine Kinases; Quinazolines; Tetraethylammonium; Tyrphostins | 2006 |
Leuprorelin acetate affects ERK1/2 activity in prostate cancer cells.
Topics: Antineoplastic Agents, Hormonal; Cell Line, Tumor; Cell Proliferation; Dihydrotestosterone; Dose-Response Relationship, Drug; Epidermal Growth Factor; ErbB Receptors; Humans; Leuprolide; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Quinazolines; Time Factors; Tyrphostins | 2006 |
Role of epidermal growth factor receptor transactivation in alpha1B-adrenoceptor phosphorylation.
Topics: Adrenergic alpha-Agonists; Androstadienes; Animals; Antibodies; Cell Line; Cricetinae; Dose-Response Relationship, Drug; Endothelin-1; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Norepinephrine; Phenylalanine; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Rats; Receptors, Adrenergic, alpha-1; Tetradecanoylphorbol Acetate; Thiophenes; Tyrphostins; Wortmannin | 2006 |
GnRH actions on rat preovulatory follicles are mediated by paracrine EGF-like factors.
Topics: Animals; Cell Adhesion Molecules; Cyclooxygenase 2; Dipeptides; Epidermal Growth Factor; ErbB Receptors; Female; Glucuronosyltransferase; Gonadotropin-Releasing Hormone; Hyaluronan Synthases; Meiosis; Ovarian Follicle; Ovulation; Phosphorylation; Progesterone; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Tyrphostins | 2006 |
Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Cycle; Cell Line, Tumor; Cell Survival; Cetuximab; Cisplatin; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Head and Neck Neoplasms; Humans; Phosphorylation; Quinazolines; Tyrosine; Tyrphostins | 2006 |
Differentiated thyroid cancer cell invasion is regulated through epidermal growth factor receptor-dependent activation of matrix metalloproteinase (MMP)-2/gelatinase A.
Topics: Adenocarcinoma, Follicular; Aprotinin; Blotting, Western; Carcinoma, Papillary; Cell Differentiation; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Flow Cytometry; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Neoplasm Invasiveness; Protease Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Serine Proteinase Inhibitors; Tetracyclines; Thyroid Neoplasms; Tumor Cells, Cultured; Tyrphostins | 2006 |
Platelet-activating factor induces ovine fetal pulmonary venous smooth muscle cell proliferation: role of epidermal growth factor receptor transactivation.
Topics: Animals; Bacterial Proteins; Cell Proliferation; Cells, Cultured; Dipeptides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Muscle, Smooth, Vascular; Mutation; Myocytes, Smooth Muscle; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Pulmonary Veins; Quinazolines; Sheep; Signal Transduction; Time Factors; Transfection; Tyrphostins | 2007 |
Epiregulin promotes proliferation and migration of renal proximal tubular cells.
Topics: Animals; Blotting, Western; Butadienes; Cell Cycle; Cell Movement; Cell Proliferation; Cells, Cultured; Chromones; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Kidney Tubules, Proximal; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oncogene Protein v-akt; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinazolines; Rabbits; Tyrphostins; Wound Healing | 2007 |
Arsenite and insulin exhibit opposing effects on epidermal growth factor receptor and keratinocyte proliferative potential.
Topics: Antimony; Arsenites; beta Catenin; Bone Morphogenetic Protein 4; Bone Morphogenetic Proteins; Cell Line, Transformed; Cell Proliferation; Cells, Cultured; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Humans; Insulin; Keratinocytes; Male; Matrix Metalloproteinase 7; PPAR delta; Pyrimidines; Quinazolines; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tyrphostins | 2007 |
Activation of NADPH oxidase by transforming growth factor-beta in hepatocytes mediates up-regulation of epidermal growth factor receptor ligands through a nuclear factor-kappaB-dependent mechanism.
Topics: Acetophenones; Animals; Anthracenes; Benzamides; Chromones; Dioxoles; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Heparin-binding EGF-like Growth Factor; Hepatocytes; Humans; Imidazoles; Intercellular Signaling Peptides and Proteins; Morpholines; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; NF-kappa B; Onium Compounds; Peptides; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; rac1 GTP-Binding Protein; Rats; Reactive Oxygen Species; Transforming Growth Factor beta; Tyrphostins; Up-Regulation | 2007 |
Lutropin/choriogonadotropin stimulate the proliferation of primary cultures of rat Leydig cells through a pathway that involves activation of the extracellularly regulated kinase 1/2 cascade.
Topics: Animals; Blotting, Western; Butadienes; Cell Proliferation; Cells, Cultured; Chorionic Gonadotropin; Cyclic AMP; Dipeptides; Epidermal Growth Factor; Flavonoids; Immunohistochemistry; Inositol Phosphates; Leydig Cells; Luteinizing Hormone; Male; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Pyrazoles; Pyrimidines; Quinazolines; Rats; Recombinant Proteins; Signal Transduction; Steroids; Tyrphostins | 2007 |
EGF-like peptides mediate FSH-induced maturation of cumulus cell-enclosed mouse oocytes.
Topics: Adenosine Monophosphate; Amphiregulin; Animals; Cells, Cultured; Cumulus Cells; EGF Family of Proteins; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Glycoproteins; Intercellular Signaling Peptides and Proteins; Meiosis; Mice; Oocytes; Peptides; Protein Kinase C; Quinazolines; Tyrphostins | 2008 |
Heparin-binding EGF-like growth factor mediates oxyhemoglobin-induced suppression of voltage-dependent potassium channels in rabbit cerebral artery myocytes.
Topics: Animals; Cerebral Arteries; Epidermal Growth Factor; ErbB Receptors; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Male; Metalloproteases; Myocytes, Smooth Muscle; Oxyhemoglobins; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated; Protein Kinase C; Quinazolines; Rabbits; Tyrphostins | 2007 |
Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Dose-Response Relationship, Drug; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Ileum; Imidazoles; Mitochondria; Mitogen-Activated Protein Kinase 14; Phosphorylation; Protein Kinase Inhibitors; Protein Transport; Pyridines; Quinazolines; Rats; RNA Interference; RNA, Small Interfering; Signal Transduction; Time Factors; Tyrphostins | 2007 |
Involvement of KATP and KvLQT1 K+ channels in EGF-stimulated alveolar epithelial cell repair processes.
Topics: Adenosine Triphosphate; Animals; Antibodies; Autocrine Communication; Benzothiazoles; Biological Transport; Cell Movement; Cell Proliferation; Cells, Cultured; Drug Synergism; Electric Conductivity; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; KCNQ1 Potassium Channel; Male; Pinacidil; Potassium; Potassium Channels; Protein Kinase Inhibitors; Pulmonary Alveoli; Quinazolines; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; Tyrphostins; Wound Healing | 2007 |
Prostaglandin E2 upregulates EGF-stimulated signaling in mitogenic pathways involving Akt and ERK in hepatocytes.
Topics: Animals; Carcinoma, Hepatocellular; Cell Culture Techniques; Cells, Cultured; Culture Media, Serum-Free; Cyclin D; Cyclins; Dinoprostone; DNA; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Gene Expression Regulation; Hepatocytes; Liver Neoplasms; Male; Pertussis Toxin; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Tyrphostins | 2008 |
EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells.
Topics: Animals; Apoptosis; Cell Survival; Cycloheximide; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibronectins; Integrin beta3; Intestinal Mucosa; MAP Kinase Kinase Kinases; Mice; Mutation; Oligopeptides; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phosphorylation; Polyamines; Protein Kinase Inhibitors; Putrescine; Pyrimidines; Quinazolines; Rats; Signal Transduction; src-Family Kinases; Time Factors; Tumor Necrosis Factor-alpha; Tyrosine; Tyrphostins | 2007 |
Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor receptor.
Topics: ADAM Proteins; ADAM17 Protein; Amphiregulin; Animals; Blotting, Western; Cells, Cultured; Cumulus Cells; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Flavonoids; Follicle Stimulating Hormone; Gene Expression; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oocytes; Phosphorylation; Quinazolines; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Swine; Transfection; Tyrphostins | 2007 |
Angiotensin II activates extracellular signal-regulated kinase independently of receptor tyrosine kinases in renal smooth muscle cells: implications for blood pressure regulation.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Kidney; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Protein Tyrosine Phosphatases; Quinazolines; Rats; Rats, Inbred WKY; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Tyrphostins; Vasoconstrictor Agents | 2008 |
Epidermal growth factor upregulates motility of Mat-LyLu rat prostate cancer cells partially via voltage-gated Na+ channel activity.
Topics: Animals; Cell Movement; Epidermal Growth Factor; Ion Channel Gating; Male; Prostatic Neoplasms; Quinazolines; Rats; Sodium Channels; Tetrodotoxin; Tyrphostins; Up-Regulation | 2008 |
PI3-kinase and mitogen-activated protein kinase in cumulus cells mediate EGF-induced meiotic resumption of porcine oocyte.
Topics: Animals; Butadienes; Cells, Cultured; Chromones; Cumulus Cells; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Meiosis; Mitogen-Activated Protein Kinases; Morpholines; Nitriles; Oocytes; Phosphatidylinositol 3-Kinases; Phosphorylation; Quinazolines; Swine; Tyrphostins | 2008 |
In human entrocytes, GLN transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent.
Topics: Amino Acid Transport System ASC; Androstadienes; Blotting, Western; Caco-2 Cells; Cell Membrane; Enterocytes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Glutamine; Humans; Minor Histocompatibility Antigens; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; rho GTP-Binding Proteins; RNA Interference; Signal Transduction; Sodium; Time Factors; Tyrphostins; Up-Regulation; Wortmannin | 2008 |
Luteinizing hormone signaling in preovulatory follicles involves early activation of the epidermal growth factor receptor pathway.
Topics: Amphiregulin; Animals; Blotting, Western; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dipeptides; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Glycoproteins; Hydroxamic Acids; Immunohistochemistry; Immunoprecipitation; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Mice; Mitogen-Activated Protein Kinases; Oocytes; Ovarian Follicle; Phosphorylation; Protein Biosynthesis; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrphostins | 2008 |
Epidermal growth factor plays a crucial role in mitogenic regulation of human brain tumor stem cells.
Topics: AC133 Antigen; Antigens, CD; Brain Neoplasms; Enzyme Inhibitors; Epidermal Growth Factor; Gefitinib; Gene Expression Regulation, Neoplastic; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Models, Biological; Peptides; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Signal Transduction; Stem Cells; Tumor Cells, Cultured; Tyrphostins | 2008 |
Epidermal growth factor receptor activation by protein kinase C is necessary for FSH-induced meiotic resumption in porcine cumulus-oocyte complexes.
Topics: Animals; Cells, Cultured; Cumulus Cells; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Meiosis; Oocytes; Phosphorylation; Protein Kinase C; Quinazolines; Receptors, Androgen; Swine; Tetradecanoylphorbol Acetate; Tyrphostins | 2008 |
Targeting EGFR activity in blood vessels is sufficient to inhibit tumor growth and is accompanied by an increase in VEGFR-2 dependence in tumor endothelial cells.
Topics: Animals; Cell Line; Cell Line, Tumor; Cell Proliferation; Cinnamates; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; Male; Mice; Mice, Nude; Neoplasms, Experimental; Neuropilin-1; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Signal Transduction; Transplantation, Heterologous; Tyrphostins; Vascular Endothelial Growth Factor Receptor-2 | 2008 |
Effects of gangliosides on the differentiation of human mesenchymal stem cells into osteoblasts by modulating epidermal growth factor receptors.
Topics: Alkaline Phosphatase; Cell Differentiation; Epidermal Growth Factor; ErbB Receptors; G(M3) Ganglioside; Gangliosides; Humans; Mesenchymal Stem Cells; Osteoblasts; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2008 |
Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.
Topics: Adaptor Proteins, Signal Transducing; Calcium-Calmodulin-Dependent Protein Kinase Type 1; Cell Line; Down-Regulation; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Humans; Intracellular Signaling Peptides and Proteins; Leupeptins; Ligands; Lysosomes; Macrolides; Phosphoproteins; Phosphorylation; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinase Inhibitors; Quinazolines; Recombinant Fusion Proteins; RNA, Small Interfering; Shc Signaling Adaptor Proteins; Src Homology 2 Domain-Containing, Transforming Protein 1; Transfection; Tyrphostins | 2008 |
EGF mediates calcium-activated chloride channel activation in the human bronchial epithelial cell line 16HBE14o-: involvement of tyrosine kinase p60c-src.
Topics: Adenosine Triphosphate; Bronchi; Cell Line; Chloride Channels; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Patch-Clamp Techniques; Proto-Oncogene Proteins pp60(c-src); Quinazolines; Recombinant Proteins; Signal Transduction; Tyrphostins | 2008 |
Photodynamic targeting of EGFR does not predict the treatment outcome in combination with the EGFR tyrosine kinase inhibitor Tyrphostin AG1478.
Topics: Cell Line, Tumor; Cell Membrane; Cell Survival; Epidermal Growth Factor; ErbB Receptors; Humans; Lysosomes; Phosphorylation; Photosensitizing Agents; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2008 |
The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-beta-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms.
Topics: Animals; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Isoenzymes; Liver Neoplasms; Mitochondria; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; Oxidative Stress; Protein Kinase Inhibitors; Quinazolines; Rats; Reactive Oxygen Species; RNA, Small Interfering; Transforming Growth Factor beta; Tyrphostins | 2009 |
A role for SNX5 in the regulation of macropinocytosis.
Topics: Animals; Carrier Proteins; Cell Line; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophage Activation; Macrophages; Membrane Lipids; Membrane Proteins; Mice; Phosphatidylinositol Phosphates; Pinocytosis; Protein Transport; Protein Tyrosine Phosphatases; Quinazolines; Sorting Nexins; Transgenes; Tyrphostins; Vesicular Transport Proteins | 2008 |
Receptor overexpression or inhibition alters cell surface dynamics of EGF-EGFR interaction: new insights from real-time single molecule analysis.
Topics: Cell Membrane; Dimerization; Epidermal Growth Factor; ErbB Receptors; HeLa Cells; Humans; Microscopy, Fluorescence; Protein Kinase Inhibitors; Quinazolines; Tyrphostins | 2009 |
Epidermal growth factor receptor (EGFR) regulates mechanical ventilation-induced lung injury in mice.
Topics: Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Intubation, Intratracheal; Mice; Mice, Inbred Strains; Neutrophils; Permeability; Protein Tyrosine Phosphatases; Pulmonary Alveoli; Quinazolines; Signal Transduction; Tyrphostins; Ventilator-Induced Lung Injury; Ventilators, Mechanical | 2008 |
Genistein decreases androgen biosynthesis in rat Leydig cells by interference with luteinizing hormone-dependent signaling.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic CMP; Dose-Response Relationship, Drug; Down-Regulation; Endocrine Disruptors; Enzyme Activators; Epidermal Growth Factor; ErbB Receptors; Genistein; Leydig Cells; Luteinizing Hormone; Male; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Long-Evans; Receptors, LH; Signal Transduction; Testosterone; Tyrphostins | 2009 |
Role of epidermal growth factor gene in the development of pancreatic cancer and efficiency of inhibitors of this gene in the treatment of pancreatic carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma; Cell Proliferation; Drug Evaluation, Preclinical; Epidermal Growth Factor; ErbB Receptors; Fluorouracil; Gene Frequency; Genetic Predisposition to Disease; Humans; Pancreatic Neoplasms; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Quinazolines; Time Factors; Tumor Cells, Cultured; Tyrphostins | 2008 |
Epidermal growth factor-activated aryl hydrocarbon receptor nuclear translocator/HIF-1{beta} signal pathway up-regulates cyclooxygenase-2 gene expression associated with squamous cell carcinoma.
Topics: Active Transport, Cell Nucleus; Aryl Hydrocarbon Receptor Nuclear Translocator; Carcinoma, Squamous Cell; Cell Line, Tumor; Cobalt; Cyclooxygenase 2; Epidermal Growth Factor; Female; Humans; Microscopy, Fluorescence; Models, Biological; Promoter Regions, Genetic; Quinazolines; RNA, Messenger; Tyrphostins; Uterine Cervical Neoplasms | 2009 |
Desmoid cell motility is induced in vitro by rhEGF.
Topics: Benzamides; Cell Division; Cell Line, Tumor; Cell Movement; Culture Media, Serum-Free; Dioxoles; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Fibromatosis, Aggressive; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Integrin beta1; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Quinazolines; Receptors, Transforming Growth Factor beta; Recombinant Proteins; RNA, Messenger; RNA, Small Interfering; Soft Tissue Neoplasms; STAT3 Transcription Factor; Transforming Growth Factor alpha; Tyrphostins | 2009 |
Role for cumulus cell-produced EGF-like ligands during primate oocyte maturation in vitro.
Topics: Amphiregulin; Animals; Betacellulin; Cumulus Cells; EGF Family of Proteins; Embryonic Development; Enzyme Inhibitors; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Fertilization in Vitro; Glycoproteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Macaca mulatta; Oocytes; Phosphorylation; Pregnancy; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tyrphostins | 2009 |
Proliferative capacity of vein graft smooth muscle cells and fibroblasts in vitro correlates with graft stenosis.
Topics: Aged; Ankle; Becaplermin; Blood Pressure; Cell Proliferation; Cells, Cultured; Constriction, Pathologic; DNA Replication; Epidermal Growth Factor; Female; Fibroblasts; Graft Occlusion, Vascular; Heparin; Humans; Hyperplasia; Lower Extremity; Lysophospholipids; Male; Middle Aged; Myocytes, Smooth Muscle; Peripheral Vascular Diseases; Platelet-Derived Growth Factor; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Quinazolines; Saphenous Vein; Sphingosine; Thrombin; Time Factors; Tyrphostins; Ultrasonography, Doppler, Duplex; Vascular Patency | 2009 |
Activation of the calcium-sensing receptor by high calcium induced breast cancer cell proliferation and TRPC1 cation channel over-expression potentially through EGFR pathways.
Topics: Base Sequence; Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; Dipeptides; DNA Primers; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Quinazolines; Receptors, Calcium-Sensing; Transcriptional Activation; TRPC Cation Channels; Tyrphostins | 2009 |
Receptor tyrosine kinases as mediators of injury-induced bradykinin B1 receptor expression in rabbit aortic smooth muscle.
Topics: Animals; Aorta; Bradykinin; Epidermal Growth Factor; ErbB Receptors; Humans; In Vitro Techniques; Interleukin-1; Muscle Contraction; Myocytes, Smooth Muscle; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Rabbits; Receptor Protein-Tyrosine Kinases; Receptor, Bradykinin B1; Tyrphostins; Up-Regulation | 2009 |
EGF-induced MMP-9 expression is mediated by the JAK3/ERK pathway, but not by the JAK3/STAT-3 pathway in a SKBR3 breast cancer cell line.
Topics: Breast Neoplasms; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Janus Kinase 1; Janus Kinase 2; Janus Kinase 3; Matrix Metalloproteinase 9; Phosphorylation; Quinazolines; RNA, Messenger; RNA, Small Interfering; STAT3 Transcription Factor; Tyrphostins | 2009 |
KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin.
Topics: Amphiregulin; Animals; beta Catenin; Cadherins; Cell Differentiation; EGF Family of Proteins; Enzyme Inhibitors; Epidermal Cells; Epidermal Growth Factor; Epidermis; ErbB Receptors; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Glycoproteins; Hair Follicle; Hedgehog Proteins; Heparin-binding EGF-like Growth Factor; Hyaluronan Receptors; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Morphogenesis; Oncogene Proteins; Quinazolines; Receptor, Fibroblast Growth Factor, Type 2; Signal Transduction; Skin; Syndecan-1; Tissue Culture Techniques; Trans-Activators; Tyrphostins; Vibrissae; Wnt Proteins; Zinc Finger Protein GLI1 | 2009 |
Tumor necrosis factor-alpha-stimulated membrane type 1-matrix metalloproteinase production is modulated by epidermal growth factor receptor signaling in human gingival fibroblasts.
Topics: Cells, Cultured; Collagen Type I; Culture Media; Enzyme Inhibitors; Enzyme Precursors; Epidermal Growth Factor; ErbB Receptors; Fibroblasts; Gelatinases; Gingiva; Heparin; Heparin-binding EGF-like Growth Factor; Humans; Intercellular Signaling Peptides and Proteins; Ligands; Matrix Metalloproteinase 14; Phosphorylation; Protein Tyrosine Phosphatases; Quinazolines; Receptors, Cell Surface; Signal Transduction; Transcriptional Activation; Transforming Growth Factor alpha; Tumor Necrosis Factor-alpha; Tyrphostins | 2009 |
Simultaneous detection of ERK-, p38-, and JNK-MAPK phosphorylation in human adipose-derived stem cells using the Cytometric Bead Array technology.
Topics: Adipose Tissue; Adult; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Flow Cytometry; Humans; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mesenchymal Stem Cells; Microspheres; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Quinazolines; Tyrphostins | 2009 |
Multipathway kinase signatures of multipotent stromal cells are predictive for osteogenic differentiation: tissue-specific stem cells.
Topics: Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Computational Biology; Epidermal Growth Factor; Humans; Immunoassay; Least-Squares Analysis; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Multivariate Analysis; Osteogenesis; Phosphoproteins; Phosphotransferases; Protein Tyrosine Phosphatases; Quinazolines; Signal Transduction; Stem Cells; Stromal Cells; Tyrphostins | 2009 |
Angiotensin II-induced migration of vascular smooth muscle cells is mediated by p38 mitogen-activated protein kinase-activated c-Src through spleen tyrosine kinase and epidermal growth factor receptor transactivation.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Butadienes; Cell Culture Techniques; Cell Migration Assays; Cell Movement; Cells, Cultured; CSK Tyrosine-Protein Kinase; Enzyme Inhibitors; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Intracellular Signaling Peptides and Proteins; Male; Muscle, Smooth, Vascular; Nitriles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein-Tyrosine Kinases; Quinazolines; Rats; Rats, Sprague-Dawley; src-Family Kinases; Syk Kinase; Transcriptional Activation; Tyrphostins | 2010 |
Epidermal growth factor can be used in lieu of follicle-stimulating hormone for nuclear maturation of porcine oocytes in vitro.
Topics: Animals; Cell Nucleus; Cells, Cultured; Drug Interactions; Embryo Culture Techniques; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Growth Factor; Female; Fertilization in Vitro; Follicle Stimulating Hormone; Oocytes; Oogenesis; Protein Biosynthesis; Quinazolines; Swine; Therapeutic Equivalency; Tyrphostins | 2010 |
Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation.
Topics: Arginase; Cell Hypoxia; Cell Proliferation; Endothelial Cells; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation; Humans; Lung; Microvessels; Models, Biological; Quinazolines; RNA, Messenger; RNA, Small Interfering; Time Factors; Tyrphostins; Urea | 2010 |
Increased Na, K-ATPase alpha2 isoform gene expression by ammonia in astrocytes and in brain in vivo.
Topics: Ammonia; Animals; Astrocytes; Blotting, Western; Brain; Cell Membrane; Cells, Cultured; Dipeptides; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Enzymologic; Genes, src; Hyperammonemia; Isoenzymes; Mice; Protease Inhibitors; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Tyrphostins; Urease | 2010 |
Epidermal hyperproliferation in mice lacking fatty acid transport protein 4 (FATP4) involves ectopic EGF receptor and STAT3 signaling.
Topics: Animals; Epidermal Growth Factor; Epidermis; Epiregulin; ErbB Receptors; Fatty Acid Transport Proteins; Keratinocytes; Mice; Mice, Mutant Strains; Mice, Transgenic; Mutation; Phenotype; Quinazolines; Signal Transduction; Skin; Skin Diseases; STAT3 Transcription Factor; Tyrphostins | 2010 |
Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH.
Topics: Amphiregulin; Animals; Cyclic GMP; EGF Family of Proteins; Epidermal Growth Factor; Epiregulin; ErbB Receptors; Female; Gap Junctions; Glycoproteins; Immunoblotting; Intercellular Signaling Peptides and Proteins; Luteinizing Hormone; Meiosis; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Ovarian Follicle; Quinazolines; Tyrphostins | 2010 |
Mechanisms of myogenic tone of coronary arteriole: Role of down stream signaling of the EGFR tyrosine kinase.
Topics: Animals; Arterioles; Cells, Cultured; Coronary Vessels; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; Janus Kinases; Mice; Mice, Inbred C57BL; Models, Biological; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; Nitroprusside; Phosphorylation; Potassium Chloride; Pressure; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Son of Sevenless Proteins; STAT Transcription Factors; STAT3 Transcription Factor; Tyrphostins; Vasoconstriction; Vasodilation | 2011 |
Epidermal growth factor treatment switches δ-opioid receptor-stimulated extracellular signal-regulated kinases 1 and 2 signaling from an epidermal growth factor to an insulin-like growth factor-1 receptor-dependent mechanism.
Topics: Blotting, Western; Cell Line; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Humans; Microfluidics; Microscopy, Confocal; Phosphorylation; Quinazolines; Receptor, IGF Type 1; Receptors, Opioid, delta; Transcriptional Activation; Tyrphostins | 2011 |
EGF-dependent induction of BCL-xL and p21CIP1/WAF1 is highly variable in HNSCC cells--implications for EGFR-targeted therapies.
Topics: bcl-X Protein; Blotting, Western; Carcinoma, Squamous Cell; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Head and Neck Neoplasms; Humans; Phosphorylation; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Tyrphostins | 2010 |
Endosomal signalling of epidermal growth factor receptors contributes to EGF-stimulated cell cycle progression in primary hepatocytes.
Topics: Animals; Cell Cycle; Cell Division; Endosomes; Epidermal Growth Factor; ErbB Receptors; Hepatocytes; Male; Microscopy, Confocal; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Thymidine; Tyrphostins | 2011 |
Role of somatostatin receptor 1 and 5 on epidermal growth factor receptor mediated signaling.
Topics: Blotting, Western; Cyclin-Dependent Kinase Inhibitor p27; Epidermal Growth Factor; ErbB Receptors; HEK293 Cells; Humans; Immunoprecipitation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Binding; Protein Multimerization; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Proto-Oncogene Proteins c-akt; Quinazolines; Receptor, ErbB-2; Receptors, Somatostatin; RNA Interference; Signal Transduction; Somatostatin; Tyrphostins | 2011 |
Activation of cumulus cell SMAD2/3 and epidermal growth factor receptor pathways are involved in porcine oocyte-cumulus cell expansion and steroidogenesis.
Topics: Animals; Benzamides; C-Reactive Protein; Cell Adhesion Molecules; Cumulus Cells; Dioxoles; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Gene Expression Regulation, Developmental; Glucuronosyltransferase; Hyaluronic Acid; Isoquinolines; Meiosis; Mice; Oocytes; Progesterone; Pyridines; Pyrroles; Quinazolines; Serum Amyloid P-Component; Signal Transduction; Smad2 Protein; Smad3 Protein; Swine; Tyrphostins | 2011 |
Epigen is induced during the interleukin-13-stimulated cell proliferation in murine primary airway epithelial cells.
Topics: Animals; Cell Culture Techniques; Cell Proliferation; Cell Separation; Cells, Cultured; Epidermal Growth Factor; Epigen; Epithelial Cells; ErbB Receptors; Interleukin-13; Ligands; Mice; Quinazolines; Trachea; Tyrphostins | 2011 |
Inhibition of radiation induced migration of human head and neck squamous cell carcinoma cells by blocking of EGF receptor pathways.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Radiation; Epidermal Growth Factor; ErbB Receptors; Flavonoids; Gamma Rays; Head and Neck Neoplasms; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Phosphatidylinositol 3-Kinases; Quinazolines; Signal Transduction; Sirolimus; Squamous Cell Carcinoma of Head and Neck; TOR Serine-Threonine Kinases; Tyrphostins | 2011 |
Effect of epidermal growth factor on follicle-stimulating hormone-induced proliferation of granulosa cells from chicken prehierarchical follicles.
Topics: Animals; Apoptosis; Cell Growth Processes; Chickens; Epidermal Growth Factor; ErbB Receptors; Female; Follicle Stimulating Hormone; Granulosa Cells; In Situ Nick-End Labeling; Ovarian Follicle; Proliferating Cell Nuclear Antigen; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tyrphostins | 2011 |
Ovarian expression and regulation of the stromelysins during the periovulatory period in the human and the rat.
Topics: Animals; Cells, Cultured; Epidermal Growth Factor; Female; Granulosa Cells; Hormone Antagonists; Humans; Matrix Metalloproteinase 10; Matrix Metalloproteinase 11; Matrix Metalloproteinase 3; Mifepristone; Ovary; Ovulation; Quinazolines; Rats; Rats, Sprague-Dawley; RNA, Messenger; Species Specificity; Theca Cells; Tyrphostins | 2012 |
Epidermal growth factor upregulates endometrial CYR61 expression via activation of the JAK2/STAT3 pathway.
Topics: Antineoplastic Agents; Cells, Cultured; Cysteine-Rich Protein 61; Drug Evaluation, Preclinical; Endometrium; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation; Humans; Janus Kinase 2; MAP Kinase Signaling System; Quinazolines; Signal Transduction; STAT3 Transcription Factor; Tyrphostins; Up-Regulation | 2012 |
Regulated intramembrane cleavage of the EGF receptor.
Topics: Amyloid Precursor Protein Secretases; Calpain; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Glycoproteins; HEK293 Cells; Humans; Ionomycin; Proteolysis; Quinazolines; Serine Endopeptidases; Serine Proteinase Inhibitors; Tyrphostins | 2012 |
Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Binding Sites; Butadienes; Cell Line, Tumor; Claudins; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; MAP Kinase Signaling System; Nitriles; Promoter Regions, Genetic; Protease Inhibitors; Protein Binding; Proto-Oncogene Proteins c-fos; Quinazolines; RNA, Messenger; RNA, Small Interfering; Transcription Factor AP-1; Tyrphostins | 2012 |
Effect of EGF-receptor tyrosine kinase inhibitor on Rab5 function during endocytosis.
Topics: Animals; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mutation; Protein Kinase Inhibitors; Quinazolines; rab GTP-Binding Proteins; rab5 GTP-Binding Proteins; Tyrphostins | 2012 |
Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway.
Topics: Analysis of Variance; Blotting, Western; Cell Line, Tumor; Cell Movement; Cobra Cardiotoxin Proteins; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Female; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; Neoplasm Metastasis; Phosphorylation; Quinazolines; Signal Transduction; Tyrphostins | 2012 |
A novel epidermal growth factor-dependent extracellular signal-regulated MAP kinase cascade involved in sperm functionality in sheep.
Topics: Animals; Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Nitriles; Quinazolines; Sheep; Sperm Capacitation; Spermatozoa; Tissue Distribution; Tyrphostins | 2012 |
Migration of retinal pigment epithelial cells is EGFR/PI3K/AKT dependent.
Topics: Cell Growth Processes; Cell Line; Cell Movement; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Retinal Pigment Epithelium; Retinaldehyde; Signal Transduction; Tyrphostins | 2013 |
Activated EGFR stimulates MUC1 expression in human uterine and pancreatic cancer cell lines.
Topics: Blotting, Western; Cell Line, Tumor; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Humans; Mucin-1; Pancreatic Neoplasms; Quinazolines; Rosiglitazone; Thiazolidinediones; Tyrphostins; Uterine Neoplasms | 2013 |
[EGFR-ERK signaling pathway down-regulates miRNA-145 in lung cancer cells].
Topics: Butadienes; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Line, Tumor; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Epithelial Cells; ErbB Receptors; Humans; Lung; Lung Neoplasms; MAP Kinase Signaling System; MicroRNAs; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitriles; Phosphorylation; Quinazolines; Tyrphostins | 2013 |
GnRH-(1-5) transactivates EGFR in Ishikawa human endometrial cells via an orphan G protein-coupled receptor.
Topics: Calcium Signaling; Cell Line, Tumor; Cell Movement; Endometrial Neoplasms; Epidermal Growth Factor; ErbB Receptors; Female; Gene Expression; Gonadotropin-Releasing Hormone; Humans; Matrix Metalloproteinase Inhibitors; Oligopeptides; Oncogene Proteins; Peptide Fragments; Phenylalanine; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidonecarboxylic Acid; Quinazolines; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, LHRH; Thiophenes; Transcriptional Activation; Tyrphostins | 2014 |
Quantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substances.
Topics: Coated Pits, Cell-Membrane; Epidermal Growth Factor; ErbB Receptors; GRB2 Adaptor Protein; HeLa Cells; Humans; Microscopy, Fluorescence; Quinazolines; Tyrphostins | 2014 |
MiRNA-181c inhibits EGFR-signaling-dependent MMP9 activation via suppressing Akt phosphorylation in glioblastoma.
Topics: Blotting, Western; Cell Line, Tumor; Chromones; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Matrix Metalloproteinase 9; MicroRNAs; Models, Genetic; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tyrphostins | 2014 |
An in vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction.
Topics: Animals; Biological Assay; Cell Communication; Cell Line, Tumor; Cell Movement; Coculture Techniques; Collagen Type I; Epidermal Growth Factor; Extracellular Matrix; Female; Fibronectins; Gefitinib; Humans; Macrophages; Mammary Glands, Human; Mice; Molecular Imaging; Quinazolines; Signal Transduction; Time-Lapse Imaging; Tyrphostins | 2014 |
Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model.
Topics: Adolescent; Air; Asthma; Bronchi; Cell Count; Cell Differentiation; Cell Proliferation; Cells, Cultured; Child; Child, Preschool; Electric Impedance; Epidermal Growth Factor; Female; Goblet Cells; Humans; Infant; Male; Models, Biological; Mucin 5AC; Quinazolines; RNA, Messenger; Tyrphostins | 2015 |
Rapidly activated epidermal growth factor receptor mediates lipopolysaccharide-triggered migration of microglia.
Topics: Animals; Cell Movement; Cells, Cultured; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Lipopolysaccharides; MAP Kinase Signaling System; Microglia; Phosphorylation; Quinazolines; Rats, Wistar; Tyrphostins | 2015 |
Novel EGFR inhibitors attenuate cardiac hypertrophy induced by angiotensin II.
Topics: Angiotensin II; Animals; Cardiomegaly; Cardiotonic Agents; Cell Line; Drug Evaluation, Preclinical; Epidermal Growth Factor; ErbB Receptors; Gene Knockdown Techniques; Mice, Inbred C57BL; Myocytes, Cardiac; Quinazolines; Rats; Tyrphostins | 2016 |
Inhibitory effect of luteolin on the proliferation of human breast cancer cell lines induced by epidermal growth factor.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromones; Epidermal Growth Factor; ErbB Receptors; Humans; Luteolin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Phosphatidylinositol 3-Kinases; Quinazolines; Tyrphostins | 2016 |
Inhibition of the Ras-ERK pathway in mitotic COS7 cells is due to the inability of EGFR/Raf to transduce EGF signaling to downstream proteins.
Topics: Animals; Caveolins; Cell Line; Chlorocebus aethiops; Clathrin; COS Cells; Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; GRB2 Adaptor Protein; MAP Kinase Signaling System; Nocodazole; Phosphorylation; Proto-Oncogene Proteins c-raf; Proto-Oncogene Proteins p21(ras); Quinazolines; raf Kinases; Shc Signaling Adaptor Proteins; Tetradecanoylphorbol Acetate; Tyrphostins | 2016 |
Epidermal growth factor-like repeats of tenascin-C-induced constriction of cerebral arteries via activation of epidermal growth factor receptors in rats.
Topics: Animals; Cerebral Arteries; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Humans; Male; Models, Animal; Quinazolines; Random Allocation; Rats, Sprague-Dawley; Recombinant Proteins; Tenascin; Tyrphostins; Vasoconstriction; Vasospasm, Intracranial | 2016 |
Quantifying receptor trafficking and colocalization with confocal microscopy.
Topics: Endocytosis; Endosomes; Epidermal Growth Factor; ErbB Receptors; Gene Expression; Genes, Reporter; Genetic Vectors; Green Fluorescent Proteins; HeLa Cells; Humans; Hydrazones; Luminescent Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Protein Transport; Quinazolines; rab5 GTP-Binding Proteins; Recombinant Fusion Proteins; Red Fluorescent Protein; Transformation, Genetic; Tyrphostins | 2017 |
Migration of oral squamous cell carcinoma cells are induced by HGF/c-Met signalling via lamellipodia and filopodia formation.
Topics: Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cetuximab; Epidermal Growth Factor; ErbB Receptors; Hepatocyte Growth Factor; Humans; Indoles; Mouth Neoplasms; Phosphatidylinositol 3-Kinases; Piperazines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Pseudopodia; Quinazolines; Signal Transduction; Sulfonamides; Tyrphostins | 2017 |
Role of GPCR (mu-opioid)-receptor tyrosine kinase (epidermal growth factor) crosstalk in opioid-induced hyperalgesic priming (type II).
Topics: Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Hyperalgesia; Male; Nociceptors; Pain Threshold; Quinazolines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Signal Transduction; Tyrphostins | 2018 |
Epidermal Growth Factor Receptor Regulation of Ewing Sarcoma Cell Function.
Topics: Bone Neoplasms; Brain-Derived Neurotrophic Factor; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; G1 Phase Cell Cycle Checkpoints; Humans; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Quinazolines; Sarcoma, Ewing; Signal Transduction; Tumor Suppressor Protein p53; Tyrphostins | 2018 |
EGF upregulates RFPL3 and hTERT via the MEK signaling pathway in non‑small cell lung cancer cells.
Topics: A549 Cells; Apoptosis; Carcinoma, Non-Small-Cell Lung; Carrier Proteins; Cell Proliferation; Epidermal Growth Factor; ErbB Receptors; Erlotinib Hydrochloride; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Molecular Targeted Therapy; Quinazolines; Telomerase; Tyrphostins | 2018 |
FOS, a Critical Downstream Mediator of PGR and EGF Signaling Necessary for Ovulatory Prostaglandins in the Human Ovary.
Topics: Adult; Benzophenones; Cells, Cultured; Chorionic Gonadotropin; Dinoprostone; Epidermal Growth Factor; Female; Humans; Isoxazoles; Mifepristone; Ovarian Follicle; Ovulation; Primary Cell Culture; Progesterone; Proto-Oncogene Proteins c-fos; Quinazolines; Receptors, Progesterone; RNA, Small Interfering; Signal Transduction; Tyrphostins; Up-Regulation | 2018 |
Label-free imaging of epidermal growth factor receptor-induced response in single living cells.
Topics: Cell Line, Tumor; Cytochalasin B; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; ErbB Receptors; Humans; Microscopy, Fluorescence; Protein Kinase Inhibitors; Quinazolines; Signal Transduction; Single-Cell Analysis; Surface Plasmon Resonance; Tyrphostins | 2018 |
Differences in embryonic gene expression and quality indicate the benefit of epidermal growth factor receptor inhibitor during prematuration to improve competence in bovine oocytes.
Topics: Animals; Cattle; Embryo, Mammalian; Embryonic Development; Enzyme Inhibitors; Epidermal Growth Factor; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; In Vitro Oocyte Maturation Techniques; Quinazolines; Tyrphostins | 2019 |
Morphine Prevents Ischemia/Reperfusion-Induced Myocardial Mitochondrial Damage by Activating δ-opioid Receptor/EGFR/ROS Pathway.
Topics: Animals; Epidermal Growth Factor; ErbB Receptors; Mitochondria, Heart; Morphine; Myocytes, Cardiac; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Quinazolines; Rats; Reactive Oxygen Species; Receptors, Opioid; Reperfusion; Reperfusion Injury; RNA, Small Interfering; Superoxides; Tyrphostins | 2022 |
Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells.
Topics: A549 Cells; Adenocarcinoma of Lung; Claudin-2; Down-Regulation; Epidermal Growth Factor; Humans; Lung Neoplasms; Tight Junctions; Transforming Growth Factor beta; Transforming Growth Factor beta1; Up-Regulation | 2023 |
Epidermal Growth Factor Receptor Mediates Neuronal Apoptosis After Subarachnoid Hemorrhage in Mice.
Topics: Animals; Apoptosis; Caspase 3; Epidermal Growth Factor; ErbB Receptors; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; NF-kappa B; Subarachnoid Hemorrhage | 2023 |