rti 82 and cocaine
rti 82 has been researched along with cocaine in 10 studies
Compound Research Comparison
| Studies (rti 82) | Trials (rti 82) | Recent Studies (post-2010) (rti 82) | Studies (cocaine) | Trials (cocaine) | Recent Studies (post-2010) (cocaine) |
|---|---|---|---|---|---|
| 10 | 0 | 2 | 32,461 | 1,096 | 9,400 |
Protein Interaction Comparison
| Protein | Taxonomy | rti 82 (IC50) | cocaine (IC50) |
|---|---|---|---|
| Amyloid-beta precursor protein | Homo sapiens (human) | 0.338 | |
| Fatty acid-binding protein, heart | Homo sapiens (human) | 0.367 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0855 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0855 | |
| D | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 5.7544 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 1.2861 | |
| Sodium-dependent dopamine transporter | Rattus norvegicus (Norway rat) | 0.4321 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.0855 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.5442 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.8885 | |
| Sodium-dependent dopamine transporter | Homo sapiens (human) | 0.3796 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 5.541 | |
| Sodium-dependent dopamine transporter | Mus musculus (house mouse) | 0.2 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.05 | |
| Transporter | Rattus norvegicus (Norway rat) | 3.2277 |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Boja, JW; Carroll, FI; Gao, Y; Kuhar, MJ; Lever, J; Lew, R; Lewin, AH; Patel, A; Philip, A; Simantov, R | 1 |
| Vaughan, RA | 2 |
| Agoston, GE; Lever, JR; Newman, AH; Vaughan, RA | 1 |
| Dutta, AK; Gaffaney, JD; Lever, JR; Reith, ME; Vaughan, RA | 1 |
| Justice, JB; Katz, JL; Kopajtic, T; Newman, AH; Wirtz, S; Zou, MF | 1 |
| Adkins, S; Duval, RA; Foster, JD; Hauck-Newman, A; Kulkarni, SS; Lever, JR; Parnas, ML; Sakrikar, DS; Vaughan, RA | 1 |
| Gaffaney, JD; Lever, JR; Newman, AH; Parnas, ML; Vaughan, RA; Zou, MF | 1 |
| Cao, J; Cha, JH; Dahal, RA; Foster, JD; Henry, LK; Krout, D; Lever, JR; Newman, AH; Pramod, AB; Sharma, B; Vaughan, RA | 1 |
| Boatang, C; Dahal, RA; Foster, JD; Henry, LK; Krout, D; Lever, JR; Newman, AH; Pramod, AB; Sharma, B; Tomlinson, MJ; Vaughan, RA; Zou, MF | 1 |
Other Studies
10 other study(ies) available for rti 82 and cocaine
| Article | Year |
|---|---|
A cocaine analog and a GBR analog label the same protein in rat striatal membranes.
Topics: Animals; Azides; Binding Sites; Carrier Proteins; Cell Membrane; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Electrophoresis, Polyacrylamide Gel; Iodine Radioisotopes; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Piperazines; Rats | 1992 |
Photoaffinity-labeled ligand binding domains on dopamine transporters identified by peptide mapping.
Topics: Affinity Labels; Amino Acid Sequence; Animals; Azides; Binding Sites; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Endopeptidases; Immunochemistry; In Vitro Techniques; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Nucleus Accumbens; Peptide Fragments; Peptide Mapping; Photochemistry; Piperazines; Rats | 1995 |
Cocaine and GBR photoaffinity labels as probes of dopamine transporter structure.
Topics: Affinity Labels; Animals; Azides; Binding Sites; Brain; Carbohydrates; Carrier Proteins; Chromatography, Affinity; Chromatography, Gel; Cocaine; Dopamine Plasma Membrane Transport Proteins; Glycosylation; Humans; Iodine Radioisotopes; Membrane Glycoproteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Piperazines; Radioligand Assay; Recombinant Proteins; Transfection | 1998 |
Differential binding of tropane-based photoaffinity ligands on the dopamine transporter.
Topics: Azides; Binding Sites; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; Hydrolysis; Iodine Radioisotopes; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Peptide Mapping; Photoaffinity Labels; Precipitin Tests; Structure-Activity Relationship; Tropanes; Trypsin | 1999 |
Dual incorporation of photoaffinity ligands on dopamine transporters implicates proximity of labeled domains.
Topics: Animals; Azides; Carrier Proteins; Cocaine; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Endopeptidases; Epitopes; In Vitro Techniques; Iodine Radioisotopes; Ligands; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Peptide Mapping; Photoaffinity Labels; Piperidines; Precipitin Tests; Rats | 2001 |
Novel tropane-based irreversible ligands for the dopamine transporter.
Topics: Animals; Azides; Benztropine; Binding, Competitive; Cell Line; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Humans; In Vitro Techniques; Isothiocyanates; Ligands; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Putamen; Radioligand Assay; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Tropanes | 2001 |
Localization of cocaine analog [125I]RTI 82 irreversible binding to transmembrane domain 6 of the dopamine transporter.
Topics: Animals; Azides; Cocaine; Cyanogen Bromide; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Epitopes; Humans; Iodine Radioisotopes; Methionine; Protein Binding; Protein Structure, Tertiary; Protein Transport; Rats; Trypsin | 2007 |
Labeling of dopamine transporter transmembrane domain 1 with the tropane ligand N-[4-(4-azido-3-[125I]iodophenyl)butyl]-2beta-carbomethoxy-3beta-(4-chlorophenyl)tropane implicates proximity of cocaine and substrate active sites.
Topics: Animals; Azides; Binding Sites; Cell Line; Cocaine; Cyanogen Bromide; Dopamine Plasma Membrane Transport Proteins; Humans; Iodine Radioisotopes; Ligands; Male; Methionine; Mutant Proteins; Peptide Fragments; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Staining and Labeling; Substrate Specificity; Tropanes; Trypsin | 2008 |
Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.
Topics: Animals; Azides; Binding Sites; Cocaine; Cyanogen Bromide; Dopamine Plasma Membrane Transport Proteins; HeLa Cells; Humans; Ligands; LLC-PK1 Cells; Mesylates; Molecular Docking Simulation; Molecular Dynamics Simulation; Mutant Proteins; Rats; Substrate Specificity; Swine | 2014 |
Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs.
Topics: Animals; Azides; Binding Sites; Cocaine; Cross-Linking Reagents; Dopamine Plasma Membrane Transport Proteins; Iodine Radioisotopes; Ligands; LLC-PK1 Cells; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Mutant Proteins; Peptide Mapping; Photoaffinity Labels; Protein Binding; Structure-Activity Relationship; Substance-Related Disorders; Swine; Tropanes | 2017 |