Compounds > rti 121
Page last updated: 2024-09-03

rti 121 and nicotine

rti 121 has been researched along with nicotine in 4 studies

Compound Research Comparison

Studies
(rti 121)		Trials
(rti 121)		Recent Studies (post-2010)
(rti 121)		Studies
(nicotine)		Trials
(nicotine)		Recent Studies (post-2010) (nicotine)
6411128,5192,2809,302

Protein Interaction Comparison

ProteinTaxonomyrti 121 (IC50)nicotine (IC50)
Neuronal acetylcholine receptor subunit alpha-4Mus musculus (house mouse)0.0055
Acetylcholine receptor subunit alphaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit betaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit gammaTetronarce californica (Pacific electric ray)0.0025
Acetylcholine receptor subunit deltaTetronarce californica (Pacific electric ray)0.0025
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0046
Neuronal acetylcholine receptor subunit alpha-2Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.0046
Neuronal acetylcholine receptor subunit beta-3Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit beta-2Homo sapiens (human)0.3256
Neuronal acetylcholine receptor subunit alpha-5Rattus norvegicus (Norway rat)0.005
Acetylcholine receptor subunit beta-like 2Drosophila melanogaster (fruit fly)4
Neuronal acetylcholine receptor subunit beta-4Homo sapiens (human)0.43
Neuronal acetylcholine receptor subunit alpha-3Homo sapiens (human)0.1866
Neuronal acetylcholine receptor subunit alpha-7Homo sapiens (human)7.6
Neuronal acetylcholine receptor subunit alpha-6Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-9Rattus norvegicus (Norway rat)0.0041
Neuronal acetylcholine receptor subunit alpha-4Homo sapiens (human)0.3456
Neuronal acetylcholine receptor subunit alpha-7Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-3Homo sapiens (human)0.0848
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)0.0087
Neuronal acetylcholine receptor subunit alpha-6Homo sapiens (human)0.0848
Neuronal acetylcholine receptor subunit alpha-5Mus musculus (house mouse)0.004
Liver carboxylesterase B-1Rattus norvegicus (Norway rat)0.045
Neuronal acetylcholine receptor subunit beta-3Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-4Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-3Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-2Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit beta-2Mus musculus (house mouse)0.004
Neuronal acetylcholine receptor subunit alpha-10Rattus norvegicus (Norway rat)0.005
Neuronal acetylcholine receptor subunit alpha-6Mus musculus (house mouse)0.004

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
McIntosh, JM; O'Leary, K; Parameswaran, N; Quik, M1
Bordia, T; Huang, LZ; Michael McIntosh, J; Parameswaran, N; Quik, M1
Bordia, T; Campos, C; McIntosh, JM; Quik, M1
Bordia, T; Drenan, RM; McGregor, M; McIntosh, JM; Quik, M1

Other Studies

4 other study(ies) available for rti 121 and nicotine

ArticleYear
Cotinine selectively activates a subpopulation of alpha3/alpha6beta2 nicotinic receptors in monkey striatum.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Azetidines; Brain; Cocaine; Conotoxins; Cotinine; Dopamine; Dopamine Agents; Female; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Receptors, Nicotinic; Saimiri

2008
Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys.
    Journal of neurochemistry, 2009, Volume: 109, Issue:3

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amphetamine; Analysis of Variance; Animals; Autoradiography; Cocaine; Conotoxins; Corpus Striatum; Cotinine; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Iodine Isotopes; Male; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotine; Oxidopamine; Protein Binding; Rats; Rats, Sprague-Dawley; Saimiri; Substantia Nigra; Time Factors

2009
Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:3

    Topics: Amphetamine; Animals; Antiparkinson Agents; Autoradiography; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channel Blockers; Central Nervous System Stimulants; Cocaine; Conotoxins; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Functional Laterality; Levodopa; Male; Mecamylamine; Neostriatum; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Stereotyped Behavior

2010
Evidence for a role for α6(∗) nAChRs in l-dopa-induced dyskinesias using Parkinsonian α6(∗) nAChR gain-of-function mice.
    Neuroscience, 2015, Jun-04, Volume: 295

    Topics: Adrenergic Agents; Analysis of Variance; Animals; Antiparkinson Agents; Benserazide; Cocaine; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Levodopa; Male; Mice; Mice, Transgenic; Nicotine; Nicotinic Agonists; Oxidopamine; Parkinsonian Disorders; Protein Binding; Receptors, Nicotinic

2015