rs 2135 has been researched along with disopyramide in 3 studies
*Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. [MeSH]
*Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. [MeSH]
| Studies (rs 2135) | Trials (rs 2135) | Recent Studies (post-2010) (rs 2135) | Studies (disopyramide) | Trials (disopyramide) | Recent Studies (post-2010) (disopyramide) |
|---|---|---|---|---|---|
| 7 | 0 | 0 | 1,659 | 206 | 64 |
| Protein | Taxonomy | rs 2135 (IC50) | disopyramide (IC50) |
|---|---|---|---|
| Solute carrier family 22 member 2 | Homo sapiens (human) | 2.9 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hashimoto, T; Koike, H; Mizuno, H; Morisawa, Y; Saito, F; Shimoji, Y; Tomita, K; Yorikane, R | 1 |
| Koike, H; Sada, T; Yorikane, R | 1 |
| Fukami, M; Hashimoto, T; Itoh, Y; Koike, H; Kumakura, S; Miyake, S; Mizuno, H; Shiga, H; Shimoji, Y; Yorikane, R | 1 |
3 other study(ies) available for rs 2135 and disopyramide
| Article | Year |
|---|---|
Synthesis and biological action of the aminotetrahydroisoquinocarbazoles and related compounds: a new class of compounds with antiarrhythmic activity.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carbazoles; Chloroform; Dogs; Female; Isoquinolines; Mice; Molecular Structure; Purkinje Fibers; Structure-Activity Relationship | 1992 |
Electrophysiologic effects of RS-2135, a new antiarrhythmic compound, on canine Purkinje fibers.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Carbazoles; Disopyramide; Dogs; Female; In Vitro Techniques; Isoquinolines; Kinetics; Male; Membrane Potentials; Microelectrodes; Purkinje Fibers; Refractory Period, Electrophysiological; Sodium Channels; Stereoisomerism | 1992 |
Antiarrhythmic and cardiovascular profiles of the fused indole compound (3aR,12R,12aR,12bS)-12-amino-2,3,3a,4,11,12,12a,12b-octahydro-10-hydrox yisoquino [2,1,8-lma]carbazol-5(1H)-one hydrochloride 1.5 hydrate.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Carbazoles; Chloroform; Disopyramide; Dogs; Female; Flecainide; Heart; Heart Conduction System; Hemodynamics; Isoquinolines; Lidocaine; Male; Mexiletine; Mice; Mice, Inbred ICR; Myocardial Contraction; Ouabain | 1991 |