rpr 100893 has been researched along with substance p in 7 studies
| Studies (rpr 100893) | Trials (rpr 100893) | Recent Studies (post-2010) (rpr 100893) | Studies (substance p) | Trials (substance p) | Recent Studies (post-2010) (substance p) |
|---|---|---|---|---|---|
| 13 | 1 | 0 | 17,289 | 277 | 2,010 |
| Protein | Taxonomy | rpr 100893 (IC50) | substance p (IC50) |
|---|---|---|---|
| Substance-P receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Substance-K receptor | Rattus norvegicus (Norway rat) | 0.2 | |
| Substance-K receptor | Homo sapiens (human) | 0.2455 | |
| Substance-P receptor | Homo sapiens (human) | 0.0011 | |
| Neuromedin-K receptor | Homo sapiens (human) | 0.125 | |
| Substance-K receptor | Mesocricetus auratus (golden hamster) | 0.148 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bock, MD; Clot, J; Emile, L; Fardin, V; Garret, C; Habert-Ortoli, E; Le Guern, J; Loquet, I; Mercken, L; Pradier, L | 1 |
| Cutrer, FM; Garret, C; Moskowitz, MA; Moussaoui, S | 1 |
| Cavero, I; Floch, A; Thiry, C | 1 |
| Chevalier, P; Duval, P; Fardin, V; Garret, C; Gordon, K; Hodgen, G; Jones, GS; Jones, H; Kerdelhué, B; Kolm, P; Lenoir, V; Williams, R | 1 |
| Alia, S; Azérad, J; Pollin, B | 1 |
| Fardin, V; Hodgen, GD; Jones, GS; Jones, HW; Kerdelhué, B; Kolm, P; Lenoir, V; Scholler, R; Williams, RF | 1 |
| Diener, HC | 1 |
1 trial(s) available for rpr 100893 and substance p
| Article | Year |
|---|---|
RPR100893, a substance-P antagonist, is not effective in the treatment of migraine attacks.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indoles; Isoindoles; Male; Middle Aged; Migraine Disorders; Substance P | 2003 |
6 other study(ies) available for rpr 100893 and substance p
| Article | Year |
|---|---|
Molecular determinants of the species selectivity of neurokinin type 1 receptor antagonists.
Topics: Androstanes; Animals; Benzimidazoles; Dipeptides; Humans; Indoles; Isoindoles; Neurokinin-1 Receptor Antagonists; Piperidines; Rats; Receptors, Neurokinin-1; Species Specificity; Substance P | 1995 |
The non-peptide neurokinin-1 antagonist, RPR 100893, decreases c-fos expression in trigeminal nucleus caudalis following noxious chemical meningeal stimulation.
Topics: Animals; Blood Proteins; Capsaicin; Guinea Pigs; Indoles; Isoindoles; Male; Meninges; Neurokinin-1 Receptor Antagonists; Pain; Proto-Oncogene Proteins c-fos; Substance P; Trigeminal Nuclei | 1995 |
Pharmacological evidence that NK-2 tachykinin receptors mediate hypotension in the guinea pig but not in the rat.
Topics: Animals; Benzamides; Blood Pressure; Guinea Pigs; Hypotension; Indoles; Isoindoles; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Piperidines; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 1996 |
Stimulatory effect of a specific substance P antagonist (RPR 100893) of the human NK1 receptor on the estradiol-induced LH and FSH surges in the ovariectomized cynomolgus monkey.
Topics: Animals; Estradiol; Female; Follicle Stimulating Hormone; Humans; Indoles; Isoindoles; Luteinizing Hormone; Macaca fascicularis; Neurokinin-1 Receptor Antagonists; Ovariectomy; Radioimmunoassay; Receptors, Neurokinin-1; Substance P | 1997 |
Effects of RPR 100893, a potent NK1 antagonist, on the jaw-opening reflex in the guinea pig.
Topics: Administration, Oral; Animals; Dental Pulp; Electric Stimulation; Guinea Pigs; Incisor; Indoles; Isoindoles; Jaw; Male; Neurokinin-1 Receptor Antagonists; Neurons, Afferent; Reaction Time; Reflex; Stereoisomerism; Substance P; Trigeminal Nerve | 1998 |
Variations in plasma levels of substance P and effects of a specific substance P antagonist of the NK(1) receptor on preovulatory LH and FSH surges and progesterone secretion in the cycling cynomolgus monkey.
Topics: Animals; Estradiol; Female; Follicle Stimulating Hormone; Follicular Phase; Indoles; Isoindoles; Luteinizing Hormone; Macaca fascicularis; Neurokinin-1 Receptor Antagonists; Ovulation; Progesterone; Receptors, Neurokinin-1; Substance P | 2000 |