Compounds > rp 73401
Page last updated: 2024-09-04

rp 73401 and zardaverine

rp 73401 has been researched along with zardaverine in 6 studies

Compound Research Comparison

Studies
(rp 73401)		Trials
(rp 73401)		Recent Studies (post-2010)
(rp 73401)		Studies
(zardaverine)		Trials
(zardaverine)		Recent Studies (post-2010) (zardaverine)
9202367222

Protein Interaction Comparison

ProteinTaxonomyrp 73401 (IC50)zardaverine (IC50)
Chain A, Phosphodiesterase 4DHomo sapiens (human)0.16
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.39
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.39
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.39
Chain A, cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.39
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.764
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)0.764
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)0.764
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Rattus norvegicus (Norway rat)0.21
cAMP-specific 3',5'-cyclic phosphodiesterase 4CRattus norvegicus (Norway rat)0.21
cAMP-specific 3',5'-cyclic phosphodiesterase 4BRattus norvegicus (Norway rat)0.21
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiens (human)0.4723
cAMP-specific 3',5'-cyclic phosphodiesterase 4ARattus norvegicus (Norway rat)0.21
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)0.94
cAMP-specific 3',5'-cyclic phosphodiesterase 4BHomo sapiens (human)0.8067
cAMP-specific 3',5'-cyclic phosphodiesterase 4CHomo sapiens (human)0.4723
cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)0.6691
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.6811
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)0.4912
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AHomo sapiens (human)0.94
cAMP-specific 3',5'-cyclic phosphodiesterase 7BHomo sapiens (human)0.94
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10AHomo sapiens (human)0.94

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Artis, DR; Bollag, G; Card, GL; England, BP; Fong, D; Gillette, S; Ibrahim, PN; Kim, SH; Lee, B; Luu, C; Milburn, MV; Powell, B; Schlessinger, J; Suzuki, Y; Tabrizizad, M; Zhang, KY1
Barlow, DJ; Ehrman, TM; Hylands, PJ1
de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R1
He, J; Ke, H; Peng, T; Qi, B; Shi, J1
Hatzelmann, A; Schudt, C; Tenor, H1
Branscheid, D; Dent, G; Magnussen, H; Rabe, KF; Rühlmann, E; Schmidt, DT; Watson, N1

Reviews

1 review(s) available for rp 73401 and zardaverine

ArticleYear
Advances in the Development of Phosphodiesterase-4 Inhibitors.
    Journal of medicinal chemistry, 2020, 10-08, Volume: 63, Issue:19

    Topics: Animals; Cyclic Nucleotide Phosphodiesterases, Type 4; Drug Development; Drug Discovery; Humans; Molecular Structure; Phosphodiesterase 4 Inhibitors; Protein Conformation; Quinolones; Vomiting

2020

Other Studies

5 other study(ies) available for rp 73401 and zardaverine

ArticleYear
Structural basis for the activity of drugs that inhibit phosphodiesterases.
    Structure (London, England : 1993), 2004, Volume: 12, Issue:12

    Topics: Binding Sites; Crystallography, X-Ray; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Structure, Tertiary

2004
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Anti-Inflammatory Agents; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Databases, Factual; Drug Design; Drugs, Chinese Herbal; Enzyme Inhibitors; JNK Mitogen-Activated Protein Kinases; Medicine, Chinese Traditional; Models, Chemical; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphodiesterase 4 Inhibitors; Structure-Activity Relationship

2010
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
    Journal of medicinal chemistry, 2016, Aug-11, Volume: 59, Issue:15

    Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship

2016
Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Benzamides; Blood Proteins; Cell Separation; Complement C5a; Cyclic Nucleotide Phosphodiesterases, Type 4; Electromagnetic Fields; Eosinophil Granule Proteins; Eosinophil-Derived Neurotoxin; Eosinophils; Humans; Inflammation Mediators; Luminescent Measurements; Naphthyridines; Neurotoxins; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridines; Pyrrolidinones; Ribonuclease, Pancreatic; Ribonucleases; Rolipram; Theophylline

1995
The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.
    British journal of pharmacology, 2000, Volume: 131, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antigens, Dermatophagoides; Benzamides; Bronchi; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glycoproteins; Histamine; Humans; In Vitro Techniques; Leukotriene C4; Lung Neoplasms; Muscle Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridines; Rolipram; Theophylline

2000