| Protein | Taxonomy | rp 73401 (IC50) | tadalafil (IC50) |
|---|
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 0.0012 |
| Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.0012 |
| Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 0.0012 |
| Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | | 0.0012 |
| Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | | 0.0012 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | | 3.0704 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Homo sapiens (human) | | 2.928 |
| High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | Homo sapiens (human) | | 3.0704 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Homo sapiens (human) | | 0.5153 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | Bos taurus (cattle) | | 5.1 |
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | Bos taurus (cattle) | | 4.05 |
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha | Homo sapiens (human) | | 2.928 |
| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | Bos taurus (cattle) | | 5.1 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | Homo sapiens (human) | | 2.928 |
| Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | Bos taurus (cattle) | | 5.1 |
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Bos taurus (cattle) | | 5.1 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | | 9.2 |
| Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta | Homo sapiens (human) | | 2.928 |
| Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | Homo sapiens (human) | | 2.507 |
| Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Homo sapiens (human) | | 3.0704 |
| Synaptic vesicular amine transporter | Rattus norvegicus (Norway rat) | | 0.012 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | | 4.6028 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | | 9.2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | | 4.6028 |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | | 3.0704 |
| Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma | Homo sapiens (human) | | 2.928 |
| cGMP-specific 3',5'-cyclic phosphodiesterase | Bos taurus (cattle) | | 0.0075 |
| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | Bos taurus (cattle) | | 5.1 |
| Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | Homo sapiens (human) | | 0.8575 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 7B | Homo sapiens (human) | | 3.0704 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | Homo sapiens (human) | | 3.0704 |
| Authors | Studies |
|---|
| Artis, DR; Bollag, G; Card, GL; England, BP; Fong, D; Gillette, S; Ibrahim, PN; Kim, SH; Lee, B; Luu, C; Milburn, MV; Powell, B; Schlessinger, J; Suzuki, Y; Tabrizizad, M; Zhang, KY | 1 |
| Jonas, U; Kedia, G; Knapp, WH; Scheller, F; Sormes, M; Stief, CG; Uckert, S | 1 |
| Bednorz, M; Ghofrani, HA; Grimminger, F; Parajuli, N; Pichl, A; Schermuly, RT; Seeger, W; Seimetz, M; Weissmann, N | 1 |
| Article | Year |
|---|
Structural basis for the activity of drugs that inhibit phosphodiesterases.Structure (London, England : 1993), 2004, Volume: 12, Issue:12
Topics: Binding Sites; Crystallography, X-Ray; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Structure, Tertiary | 2004 |
Effects of phosphodiesterase inhibitors on tension induced by norepinephrine and accumulation of cyclic nucleotides in isolated human prostatic tissue.Urology, 2008, Volume: 71, Issue:3
Topics: Aged; Benzamides; Carbolines; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Humans; Imidazoles; In Vitro Techniques; Male; Middle Aged; Norepinephrine; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Piperazines; Prostate; Purines; Pyridines; Rolipram; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride | 2008 |
Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice.PloS one, 2015, Volume: 10, Issue:6
Topics: Animals; Benzamides; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Hypertension, Pulmonary; Lung; Lung Compliance; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; Phosphodiesterase 4 Inhibitors; Phosphodiesterase 5 Inhibitors; Pulmonary Disease, Chronic Obstructive; Pulmonary Emphysema; Pyridines; Smoke; Smoking; Tadalafil | 2015 |