rp 73401 has been researched along with cdp 840 in 7 studies
| Studies (rp 73401) | Trials (rp 73401) | Recent Studies (post-2010) (rp 73401) | Studies (cdp 840) | Trials (cdp 840) | Recent Studies (post-2010) (cdp 840) |
|---|---|---|---|---|---|
| 92 | 0 | 23 | 18 | 0 | 3 |
| 92 | 0 | 23 | 17 | 1 | 0 |
| Protein | Taxonomy | rp 73401 (IC50) | cdp 840 (IC50) |
|---|---|---|---|
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Rattus norvegicus (Norway rat) | 10 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Rattus norvegicus (Norway rat) | 10 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Rattus norvegicus (Norway rat) | 10 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | 0.7675 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Rattus norvegicus (Norway rat) | 10 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | 0.1028 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | 0.1032 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | 0.1029 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andresen, CJ; Cheng, JB; Cohan, VL; Decker, C; DiCapua, FM; Duplantier, AJ; Johnson, KL; Kraus, KG; Turner, CR; UmLand, JP; Watson, JW; Wester, RT; Williams, AS; Williams, JA | 1 |
| Djuric, S; Hanney, B; He, W; Huang, FC; Liang, G; Mason, J; Miller, B; Souness, J | 1 |
| Alexander, R; Allen, R; Blease, K; Bloxham, D; Boyd, E; Catterall, C; Eaton, M; Gozzard, N; Head, J; Higgs, G; Holbrook, M; Howat, D; Hughes, B; Hughes, P; James, T; Kingaby, R; Lisle, H; Lumb, S; Merriman, M; Owens, R; Perry, M; Russell, A; Smith, B; Wales, M; Warrellow, G | 1 |
| Gozzard, N; Higgs, G; Holbrook, M; Hughes, B; James, T | 1 |
| Cooper, N; Gristwood, RW; Hellewell, PG; Macari, DM; Miotla, JM; Teixeira, MM; Warneck, J; Wills, RE | 1 |
| Egging, EA; Gullikson, GW; Hammerbeck, DM; Hupperts, AM; Johnson, DD; McGurran, SM; Radziszewski, PL | 1 |
| Akuta, K; Hirose, R; Ichimura, M; Manabe, H; Nonaka, H; Ohshima, E; Sato, S; Yanagawa, K | 1 |
7 other study(ies) available for rp 73401 and cdp 840
| Article | Year |
|---|---|
7-Oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridines as novel inhibitors of human eosinophil phosphodiesterase.
Topics: Airway Obstruction; Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Cell Count; Cell Line; Cyclic AMP; Cytokines; Dihydropyridines; Drug Evaluation, Preclinical; Eosinophils; Guinea Pigs; Humans; In Vitro Techniques; Isoenzymes; Macaca fascicularis; Molecular Conformation; Neutrophils; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrazoles; Pyrrolidinones; Rolipram; Structure-Activity Relationship | 1998 |
Novel cyclic compounds as potent phosphodiesterase 4 inhibitors.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Brain; Cyclic Nucleotide Phosphodiesterases, Type 4; Dogs; Endotoxemia; Female; Guinea Pigs; In Vitro Techniques; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Phosphodiesterase Inhibitors; Pyridines; Structure-Activity Relationship; Tumor Necrosis Factor-alpha; Vomiting | 1998 |
The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Airway Resistance; Analysis of Variance; Animals; Asthma; Benzamides; Bronchoconstriction; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Dose-Response Relationship, Drug; Eosinophilia; Guinea Pigs; Humans; Interleukin-5; Isoenzymes; Lung; Male; Neutrophils; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Pyrrolidinones; Rabbits; Rats; Rolipram | 1996 |
Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor.
Topics: Analysis of Variance; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Carbachol; Cricetinae; Disease Models, Animal; Enzyme Inhibitors; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Lung; Male; Muscle Contraction; Muscle Relaxation; Parasympathomimetics; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Rolipram; Trachea; Vagus Nerve | 1996 |
A comparison of the inhibitory activity of PDE4 inhibitors on leukocyte PDE4 activity in vitro and eosinophil trafficking in vivo.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Benzamides; Cell Movement; Cyclic Nucleotide Phosphodiesterases, Type 4; Dermatitis; Eosinophils; Female; Guinea Pigs; Humans; Macrophages; Male; Neutrophils; Phosphodiesterase Inhibitors; Pyridines; Pyrrolidinones; Rolipram; Skin | 1999 |
Effects of several glucocorticosteroids and PDE4 inhibitors on increases in total lung eosinophil peroxidase (EPO) levels following either systemic or intratracheal administration in sephadex- or ovalbumin-induced inflammatory models.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Asthma; Beclomethasone; Benzamides; Budesonide; Cyclic Nucleotide Phosphodiesterases, Type 4; Dexamethasone; Dextrans; Disease Models, Animal; Enzyme Inhibitors; Eosinophil Peroxidase; Eosinophils; Fluticasone; Glucocorticoids; Guinea Pigs; Inflammation; Lung; Male; Ovalbumin; Peroxidases; Pyridines; Rats; Rats, Sprague-Dawley; Rolipram | 2000 |
Correlation between emetic effect of phosphodiesterase 4 inhibitors and their occupation of the high-affinity rolipram binding site in Suncus murinus brain.
Topics: Animals; Benzamides; Binding Sites; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Kinetics; Male; Molecular Structure; Naphthyridines; Phosphodiesterase 4 Inhibitors; Phosphodiesterase Inhibitors; Pyridines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Rolipram; Shrews; Tritium; Vomiting; Xanthines | 2007 |