Compounds > rp 73401
Page last updated: 2024-09-04

rp 73401 and 1-methyl-3-isobutylxanthine

rp 73401 has been researched along with 1-methyl-3-isobutylxanthine in 3 studies

Compound Research Comparison

Studies
(rp 73401)		Trials
(rp 73401)		Recent Studies (post-2010)
(rp 73401)		Studies
(1-methyl-3-isobutylxanthine)		Trials
(1-methyl-3-isobutylxanthine)		Recent Studies (post-2010) (1-methyl-3-isobutylxanthine)
920235,1485279

Protein Interaction Comparison

ProteinTaxonomyrp 73401 (IC50)1-methyl-3-isobutylxanthine (IC50)
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7AHomo sapiens (human)8.1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4DHomo sapiens (human)31
Chain A, Phosphodiesterase 9AHomo sapiens (human)500
Chain A, Class I phosphodiesterase PDEB1Leishmania major580
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8AHomo sapiens (human)698
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)40
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9AHomo sapiens (human)117.2
Phosphodiesterase Bos taurus (cattle)9.9
cGMP-dependent 3',5'-cyclic phosphodiesteraseHomo sapiens (human)4
cGMP-specific 3',5'-cyclic phosphodiesteraseHomo sapiens (human)3.1667
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A Bos taurus (cattle)9.9
Adenosine receptor A1Rattus norvegicus (Norway rat)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1AHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BBos taurus (cattle)9.9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BHomo sapiens (human)3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1BRattus norvegicus (Norway rat)0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase BHomo sapiens (human)0.242
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CHomo sapiens (human)3.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase AHomo sapiens (human)7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1CRattus norvegicus (Norway rat)0.1
Phosphodiesterase Rattus norvegicus (Norway rat)0.1

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Esch, IJ; de Graaf, C; Jansen, C; Kanev, GK; Kooistra, AJ; Leurs, R1
Hatzelmann, A; Schudt, C; Tenor, H1
Branscheid, D; Dent, G; Magnussen, H; Rabe, KF; Rühlmann, E; Schmidt, DT; Watson, N1

Other Studies

3 other study(ies) available for rp 73401 and 1-methyl-3-isobutylxanthine

ArticleYear
PDEStrIAn: A Phosphodiesterase Structure and Ligand Interaction Annotated Database As a Tool for Structure-Based Drug Design.
    Journal of medicinal chemistry, 2016, Aug-11, Volume: 59, Issue:15

    Topics: Databases, Protein; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Structure-Activity Relationship

2016
Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions.
    British journal of pharmacology, 1995, Volume: 114, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Antagonists; Benzamides; Blood Proteins; Cell Separation; Complement C5a; Cyclic Nucleotide Phosphodiesterases, Type 4; Electromagnetic Fields; Eosinophil Granule Proteins; Eosinophil-Derived Neurotoxin; Eosinophils; Humans; Inflammation Mediators; Luminescent Measurements; Naphthyridines; Neurotoxins; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyridines; Pyrrolidinones; Ribonuclease, Pancreatic; Ribonucleases; Rolipram; Theophylline

1995
The effect of selective and non-selective phosphodiesterase inhibitors on allergen- and leukotriene C(4)-induced contractions in passively sensitized human airways.
    British journal of pharmacology, 2000, Volume: 131, Issue:8

    Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Antigens, Dermatophagoides; Benzamides; Bronchi; Bronchodilator Agents; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glycoproteins; Histamine; Humans; In Vitro Techniques; Leukotriene C4; Lung Neoplasms; Muscle Contraction; Phosphodiesterase Inhibitors; Pyridazines; Pyridines; Rolipram; Theophylline

2000