roxatidine acetate has been researched along with piperidines in 113 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (18.58) | 18.7374 |
| 1990's | 56 (49.56) | 18.2507 |
| 2000's | 20 (17.70) | 29.6817 |
| 2010's | 14 (12.39) | 24.3611 |
| 2020's | 2 (1.77) | 2.80 |
| Authors | Studies |
|---|---|
| Halabi, A; Kirch, W; Nokhodian, A | 1 |
| Bright-Asare, P; Cobert, BL; Fitch, DD; Gilinsky, NH; Kerr, RM; Lanza, FL; Savitsky, JP | 1 |
| Kawano, O; Misaki, N; Nakaji, S; Narita, M; Okabe, S; Takinami, Y | 1 |
| Igata, H; Kato, S; Okabe, S; Seiki, M; Shimosako, K; Takagi, K; Yamaji, Y | 1 |
| Audibert, G; Bigard, O; Haberer, JP; Hartemann, D; Saunier, C | 1 |
| Andoh, K; Hashimoto, Y; Koga, Y; Kojima, A; Shima, T | 1 |
| Pidgen, A; Seibert-Grafe, M | 1 |
| Collins, M; Cooper, BT; Daneshmend, TK; Hawkey, CJ; Langman, MJ; Logan, RF; Long, RG; Street, R; Walt, RP | 1 |
| Enomoto, A; Kawanishi, M; Kurokawa, Y; Shimada, Y | 1 |
| McTavish, D; Murdoch, D | 1 |
| Bonfils, S; Chen, WW; Kolsky, H; Lewin, MJ | 1 |
| Chijiiwa, Y; Fujishima, H; Harada, N; Kabemura, T; Misawa, T; Nawata, H; Tanaka, A; Yoshida, K | 1 |
| Walt, RP | 1 |
| Kato, M; Matsuo, Y; Natomi, H; Saito, E; Seki, A; Sugano, K; Takaku, F; Yasumura, R | 1 |
| Nakamura, K; Tanaka, E | 1 |
| Hashimoto, M; Hirose, M; Kasano, T; Kihira, K; Kimura, K; Sato, K; Yoshida, Y | 1 |
| Bender, W; Labs, R; Merki, HS | 1 |
| Bender, W; Brockmeier, D | 1 |
| Aoi, R; Ishioka, T; Ogata, H; Takeuchi, H; Yoshimura, N | 1 |
| Honma, S; Iwamura, S; Kawabe, Y; Shibata, K; Tsukamoto, K | 1 |
| Konishi, H; Morita, K; Ono, T; Shimakawa, H | 1 |
| Beil, W; Hannemann, H; Sewing, KF | 1 |
| Burrows, JL; Jolley, KW; Sullivan, DJ | 1 |
| Brockmeier, D; Lameire, N; Rosenkranz, B | 1 |
| Bender, W; Dammann, HG; de Looze, SM; Labs, R | 1 |
| Bonfils, S; Chen, WW; Vatier, J | 1 |
| Kaufmann, D; Kempf, M; Merki, HS; Muessig, V; Neumann, J; Roehmel, J; Scheurle, E; Walt, RP; Witzel, L | 1 |
| Kurz-Muller, K; Tryba, M | 1 |
| Bickel, M; Herling, AW; Schoelkens, B; Scholtholt, J | 1 |
| Collins, JD | 1 |
| Doi, M; In, Y; Inoue, M; Ishida, T; Shibata, K | 1 |
| Kaufmann, D; Kempf, M; Merki, HS; Müssig, V; Neumann, J; Röhmel, J; Scheurle, E; Walt, RP; Witzel, L | 1 |
| Burkhardt, F; Dammann, HG; Wolf, N | 1 |
| Fujino, MA; Kobayashi, K; Morozumi, A; Ohtsuka, H; Sano, S; Suzuki, Y; Tachikawa, H; Uchida, N; Ueda, F; Yamamoto, Y | 1 |
| Ikarashi, Y; Misaki, N; Ohba, S; Ohbayashi, S; Uchida, M | 1 |
| Gladziwa, U; Klotz, U; Sieberth, HG; Wagner, S | 1 |
| Jackisch, P; Müller, P; Simon, B | 1 |
| Abbati, GL; Cioni, G; Cristani, A; Rigo, G; Sardini, C; Tincani, E; Ventura, E; Ventura, P | 1 |
| Chijiiwa, Y; Maruoka, A; Nawata, H; Tanaka, M | 1 |
| Daake, H; Eisold, H; Gorbauch, T; Kriech, W; Raedsch, R; Schreiber, H | 1 |
| Beil, W; Sewing, KF | 1 |
| Amarapurkar, DN; Desai, HG; Parikh, SS | 1 |
| Bosseckert, H; Ernst, R; Kriech, W; Schunter, C | 1 |
| Aoki, T; Fukuda, S; Hanyu, N; Hashimoto, Y; Iikura, M; Ohira, Y | 1 |
| Azian, M; Chuah, SY; Goh, KL; Lo, YL; Ong, KK; Parasakthi, N; Peh, SC; Wong, NW | 1 |
| Hamada, K; Kobayashi, F; Sekiguchi, H; Taga, F; Uchida, H | 1 |
| Aijima, H; Hamada, K; Nishino, K; Sekiguchi, H; Taga, F; Uchida, H | 1 |
| Abe, K; Furukawa, Y; Katano, K; Mizunashi, K | 1 |
| Ikarashi, Y; Kawano, O; Misaki, N; Ohba, S; Uchida, M | 1 |
| Bianchi Porro, G; Canali, A; Lazzaroni, M | 1 |
| Furuhata, M; Nagai, N; Ogata, H | 1 |
| Ciacci, C; De Luca, A; Del Vecchio Blanco, C; Mazzacca, G; Ricci, V; Romano, M; Zarrilli, R | 1 |
| Bargiggia, S; Bensi, G; Bianchi Porro, G; Canali, A; Lazzaroni, M; Sangaletti, O | 1 |
| Athanassova, R; Ivanov, C; Kotsev, V; Lyutakov, G; Nikolov, G; Petkov, O; Petrov, P; Savov, E; Taskov, M; Tsvetkova, E | 1 |
| Csepregi, A; Nemesánszky, E | 1 |
| Botzler, R; Friedrich, P; Kriech, W; Mayershofer, R | 1 |
| Okabe, S; Takahashi, S | 2 |
| Horiuchi, Y; Katagiri, T | 1 |
| Milenov, K; Shahbazian, A; Todorov, S; Vassileva, M; Zamfirova, R | 1 |
| Belicchi, M; Celle, G; Cutela, P; Di Mario, F; Ferrana, M; Malesci, A; Mela, GS; Savarino, V; Termini, R; Vigneri, S; Zentilin, P | 1 |
| Araki, I; Maeda, A; Matsuki, A; Miyata, A; Shirasaki, S; Yatsu, Y; Yoshida, H | 1 |
| Chinapak, O; Kachintorn, U; Khow-ean, U; Kludchareon, N; Kositchaiwat, C; Leethochawalit, M; Lekhayananda, S; Saowaros, V; Suttinont, C; Vongphanich, V | 1 |
| Hagishita, S; Ishihara, S; Ishihara, Y; Ishikawa, M; Kawanishi, Y; Takahashi, K; Tsushima, T | 1 |
| Berstad, A; Hatlebakk, JG | 1 |
| Fujisaki, N; Ikeda, Y; Kuwahara, M; Ohtsuka, Y; Sakemi, T | 1 |
| Hagishita, S; Ishihara, S; Ishihara, Y; Ishikawa, M; Kawanishi, Y; Tsushima, T | 1 |
| Ivanov, CH; Klouchek, E; Krushkov, I; Marazova, K; Popov, A | 1 |
| Hotta, K; Ichikawa, T; Ishihara, K; Saigenji, K | 1 |
| Higuchi, S; Isobe, Y; Kijima, H; Muramatsu, M; Suzuki, M; Yokomori, S | 1 |
| Hirakawa, N; Kashiwaba, N; Kutsuma, T; Matsumoto, H; Sekine, A; Sekine, Y; Yamaura, T | 1 |
| Buschauer, A; Schulze, FR; Schunack, W | 1 |
| Frick, A; Möller, H; Wirbitzki, E | 1 |
| Hotta, K; Ichikawa, T; Ishihara, K; Kawakami, T; Kusakabe, T | 1 |
| Ayukawa, O; Kariyazono, H; Moriyama, Y; Nakamura, K; Shinkawa, T; Taira, A; Toyohira, H; Yamada, K; Yamaguchi, T; Yamashita, T; Yotsumoto, G | 1 |
| Chen, WH; Lin, BR; Lin, JT; Wang, JT; Wang, TH; Yang, JC | 1 |
| Horiuchi, Y | 1 |
| Abo, T; Fukuda, M; Kawamura, T; Miyaji, C; Toyabe, S; Watanabe, H | 1 |
| Ashida, H; Chihara, E; Fukushima, H; Ibuki, T; Namba, M; Tanaka, Y | 1 |
| Takase, S; Tsutsumi, M; Ueshima, Y | 1 |
| Honma, S; Iwamura, S; Nakayama, M; Numazawa, S; Oguro, T; Sasaki, M; Tsukamoto, K; Yoshida, T | 1 |
| Hirohata, Y; Kanagawa, K; Kume, K; Murata, I; Nakamura, H; Otsuki, M; Yoshikawa, I | 1 |
| Adachi, K; Fujishiro, H; Kinoshita, Y; Komazawa, Y; Mihara, T | 1 |
| Izumi, K; Okabe, S; Tomita, K | 1 |
| Ali, SM; Asmat, F; Maheshwari, A | 1 |
| Hashimoto, H; Hirota, K; Kudo, M; Kushikata, T; Matsuki, A | 1 |
| Choi, I; Gwak, H; Moon, H; Oh, J | 1 |
| Igawa, K; Matsunaga, T; Nishioka, K; Yokozeki, H | 1 |
| Hashimoto, H; Hirota, K; Kudo, M; Kushikata, T | 2 |
| Nakamura, E; Okabe, S; Tomita, K | 1 |
| Dobashi, K; Ishizuka, T; Kawamura, O; Kobayashi, S; Kusano, M; Mori, M; Ohki, I; Shimizu, Y; Shimoyama, Y; Sunaga, N; Tokushima, M; Utsugi, M | 1 |
| Balthasar, JP; Choi, JW; Hong, DK; Kim, JJ; Shin, BS; Yoo, SD | 1 |
| Choi, SJ; Choi, SK; Lee, HW; Lee, KT; Ryu, JH | 1 |
| Wang, JM; Zhang, BY; Zhang, H; Zhang, QY; Zhao, DM | 1 |
| Hashimoto, H; Hirota, K; Imai, A; Kudo, M; Kushikata, T | 1 |
| Higuchi, K; Murano, M; Tokioka, S; Umegaki, E; Yoda, Y | 1 |
| Agrawal, SS; Alvin Jose, M | 1 |
| Agrawal, SS; Jose, MA | 1 |
| Ohashi, A; Okuyama, R; Saiki, M | 1 |
| Hibi, T; Hosoe, N; Ida, Y; Imaeda, H; Iwao, Y; Nakamura, R; Ogata, H; Saito, Y; Suzuki, H | 1 |
| An, HJ; Cho, EJ; Cho, YW; Choi, HE; Choi, JH; Kim, HM; Ko, J; Lee, KT; Shin, JS | 1 |
| Maheshwari, A; Sharma, D; Sharma, M | 1 |
| Abe, Y; Endo, H; Fujita, K; Goto, A; Gotoh, E; Hosono, K; Iida, H; Inamori, M; Kato, S; Kobayashi, N; Koide, T; Kubota, K; Maeda, S; Nakajima, A; Sakai, E; Sakamoto, Y; Sekino, Y; Takahashi, H; Tokoro, C; Uchiyama, T; Yoneda, M | 1 |
| Azuma, R; Kawashima, H; Miyazawa, K; Nagao, K; Nakamura, H; Sato, I | 1 |
| Ichikawa, T; Ishihara, K; Iwai, T; Kida, M; Koizumi, W; Shikama, N; Yamamoto, H | 1 |
| Hirota, K; Kitayama, M; Nakai, K; Niwa, H; Satoh, Y | 1 |
| Alisch, R; Buschauer, A; Elz, S; Sadek, B | 1 |
| An, HJ; Cheon, SY; Chung, KS; Lee, KT; Lee, M; Lee, NY | 1 |
| Li, J; Tang, X; Wang, S; Xie, M; Ze, R; Zhang, B | 1 |
| Gao, M; Ji, L; Song, H; Tian, L; Wang, T | 1 |
| Fan, X; Li, X; Li, Y; Tu, S; Xiao, G; Xu, B; Yuan, F; Zhang, P | 1 |
9 review(s) available for roxatidine acetate and piperidines
| Article | Year |
|---|---|
Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders.
Topics: Animals; Drug Evaluation; Histamine H2 Antagonists; Humans; Peptic Ulcer; Piperidines | 1991 |
Clinical importance of the new H2-antagonists.
Topics: Animals; Famotidine; Histamine H2 Antagonists; Humans; Nizatidine; Peptic Ulcer; Piperidines; Thiazoles | 1989 |
Pharmacokinetic characteristics of roxatidine.
Topics: Aged; Aged, 80 and over; Drug Interactions; Female; Histamine H2 Antagonists; Humans; Lactation; Piperidines; Pregnancy; Renal Dialysis | 1989 |
Comparative pharmacology of histamine H2-receptor antagonists.
Topics: Histamine H2 Antagonists; Humans; Piperidines; Ranitidine; Receptors, Histamine H2 | 1988 |
Pharmacokinetics of histamine (H2)-receptor antagonists, including roxatidine, in chronic renal failure.
Topics: Anti-Ulcer Agents; Cimetidine; Famotidine; Histamine H2 Antagonists; Humans; Kidney Failure, Chronic; Piperidines; Ranitidine; Renal Dialysis; Thiazoles | 1988 |
Clinical characteristics of roxatidine acetate: a review.
Topics: Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Gastric Acid; Histamine H2 Antagonists; Humans; Piperidines; Ranitidine; Stomach Ulcer | 1988 |
Therapeutic approach in patients with concomitant disease/drug--drug interactions (roxatidine acetate).
Topics: Anti-Ulcer Agents; Cimetidine; Drug Interactions; Histamine H2 Antagonists; Humans; Peptic Ulcer; Piperidines; Ranitidine; Structure-Activity Relationship | 1988 |
[H2-receptor antagonists and alcohol: clinical significance].
Topics: Cimetidine; Clinical Medicine; Drug Interactions; Ethanol; Famotidine; Gastric Mucosa; Histamine H2 Antagonists; Humans; Liver; Nizatidine; Piperidines; Ranitidine | 1996 |
Pharmacokinetic optimisation in the treatment of gastro-oesophageal reflux disease.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antacids; Benzimidazoles; Cimetidine; Cisapride; Domperidone; Famotidine; Gastroesophageal Reflux; Histamine H2 Antagonists; Humans; Lansoprazole; Metoclopramide; Nizatidine; Omeprazole; Pantoprazole; Piperidines; Proton Pump Inhibitors; Ranitidine; Sucralfate; Sulfoxides | 1996 |
37 trial(s) available for roxatidine acetate and piperidines
| Article | Year |
|---|---|
Haemodynamic effects of roxatidine, an H2-receptor antagonist.
Topics: Blood Pressure; Cardiac Output; Coronary Disease; Double-Blind Method; Electrocardiography; Heart Failure; Heart Rate; Hemodynamics; Histamine H2 Antagonists; Humans; Middle Aged; Piperidines; Stroke Volume | 1992 |
A multicenter, double-blind, randomized, placebo-controlled comparison of nocturnal roxatidine in the treatment of active duodenal ulcer disease. Multicenter Roxatidine Cooperative Study Group.
Topics: Abdominal Pain; Adult; Aged; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; Female; Histamine H2 Antagonists; Humans; Logistic Models; Male; Middle Aged; Piperidines; Severity of Illness Index | 1992 |
Lack of effect of multiple dose sucralfate on the pharmacokinetics of of roxatidine acetate.
Topics: Biological Availability; Drug Interactions; Histamine H2 Antagonists; Humans; Male; Piperidines; Sucralfate | 1991 |
A comparison of roxatidine and ranitidine for the acute treatment of duodenal ulcer.
Topics: Adult; Aged; Duodenal Ulcer; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Piperidines; Ranitidine | 1991 |
[Clinical evaluation of roxatidine acetate hydrochloride injection as preanesthetic medication].
Topics: Adult; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Piperidines; Pneumonia, Aspiration; Preanesthetic Medication | 1991 |
[Plasma pharmacokinetics of roxatidine in the healthy man: correlation with gastric antisecretory effect].
Topics: Adult; Cimetidine; Double-Blind Method; Gastric Juice; Histamine H2 Antagonists; Humans; Male; Piperidines; Random Allocation; Ranitidine | 1990 |
Effects of combined use of roxatidine and pirenzepine on gastric secretion in humans.
Topics: Adult; Depression, Chemical; Drug Synergism; Gastric Acid; Gastric Juice; Gastric Mucosa; Histamine H2 Antagonists; Humans; Male; Piperidines; Pirenzepine | 1990 |
The effect of roxatidine acetate and cimetidine on hepatic drug clearance assessed by simultaneous administration of three model substrates.
Topics: Adult; Antipyrine; Cimetidine; Half-Life; Histamine H2 Antagonists; Humans; Indocyanine Green; Liver; Male; Pharmaceutical Preparations; Piperidines; Trimethadione | 1989 |
Safety and efficacy of roxatidine acetate. Evidence from pharmacodynamic and clinical trials.
Topics: Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Histamine H2 Antagonists; Humans; Peptic Ulcer; Piperidines; Random Allocation; Ranitidine | 1989 |
Effects of roxatidine acetate hydrochloride and cimetidine on the pharmacokinetics of theophylline in healthy subjects.
Topics: Adult; Aminophylline; Cimetidine; Half-Life; Humans; Infusions, Intravenous; Male; Piperidines; Smoking; Theophylline | 1989 |
Clinical characteristics of roxatidine acetate: a review.
Topics: Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Gastric Acid; Histamine H2 Antagonists; Humans; Piperidines; Ranitidine; Stomach Ulcer | 1988 |
Inhibition of food-stimulated acid secretion (intragastric titration) by roxatidine acetate. Dose-response study.
Topics: Adult; Dose-Response Relationship, Drug; Food; Gastric Acid; Histamine H2 Antagonists; Humans; Male; Piperidines | 1988 |
Assessment of intragastric acidity in man: modern aspects, reproducibility of intragastric pH-monitoring, and pharmacodynamic results obtained with H2-receptor antagonists.
Topics: Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Gastric Acidity Determination; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Monitoring, Physiologic; Piperidines; Random Allocation; Ranitidine | 1988 |
The effects of roxatidine acetate (HOE-760) on 24-hour intragastric acidity in healthy volunteers: comparison with ranitidine and placebo.
Topics: Adolescent; Adult; Double-Blind Method; Gastric Acid; Histamine H2 Antagonists; Humans; Middle Aged; Piperidines; Ranitidine; Reference Values | 1988 |
[Effective prevention of indomethacin-induced gastroduodenal mucosal lesions with roxatidine acetate].
Topics: Adult; Cross-Over Studies; Histamine H2 Antagonists; Humans; Indomethacin; Male; Peptic Ulcer; Piperidines; Single-Blind Method | 1995 |
Quality of peptic ulcer healing induced by lansoprazole and roxatidine.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Duodenal Ulcer; Female; Helicobacter pylori; Humans; Lansoprazole; Male; Middle Aged; Omeprazole; Peptic Ulcer; Piperidines; Proton Pump Inhibitors; Stomach Ulcer | 1995 |
[Comparison of the protective effects of roxatidine and misoprostol on diclofenac gastroduodenal pathology. An endoscopic, controlled study of volunteers].
Topics: Adult; Anti-Ulcer Agents; Delayed-Action Preparations; Diclofenac; Gastric Acid; Gastroscopy; Histamine H2 Antagonists; Humans; Misoprostol; Piperidines; Stomach Ulcer | 1994 |
[Treatment of peptic ulcer in internal medicine practice. A multicenter comparative study with roxatidine and cimetidine].
Topics: Adolescent; Adult; Aged; Cimetidine; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Peptic Ulcer; Piperidines | 1993 |
[Effects of the histamine H2 receptor antagonist roxatidine acetate on stomach and liver alcohol dehydrogenase and serum alcohol level].
Topics: Adult; Alcohol Dehydrogenase; Alcohol Drinking; Animals; Cimetidine; Ethanol; Female; Guinea Pigs; Histamine H2 Antagonists; Humans; Liver; Male; Metabolic Clearance Rate; Piperidines; Stomach | 1993 |
New H2-receptor antagonist--roxatidine acetate--in treatment of duodenal ulcer.
Topics: Cimetidine; Double-Blind Method; Duodenal Ulcer; Female; Histamine H2 Antagonists; Humans; Male; Piperidines | 1993 |
[Early evening and late evening administration of roxatidine acetate in therapy of duodenal ulcer].
Topics: Adolescent; Adult; Aged; Drug Administration Schedule; Duodenal Ulcer; Duodenoscopy; Female; Histamine H2 Antagonists; Humans; Intestinal Mucosa; Male; Middle Aged; Piperidines | 1993 |
Roxithromycin in the eradication of Helicobacter pylori.
Topics: Anti-Ulcer Agents; Bismuth; Drug Therapy, Combination; Helicobacter Infections; Helicobacter pylori; Histamine H2 Antagonists; Humans; Omeprazole; Organometallic Compounds; Piperidines; Roxithromycin | 1994 |
Double-blind, randomized trial of roxatidine 150 mg in the early evening versus bedtime administration in the short-term treatment of duodenal ulcer.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Ulcer Agents; Double-Blind Method; Duodenal Ulcer; Female; Follow-Up Studies; Humans; Male; Middle Aged; Piperidines; Time Factors; Treatment Outcome | 1995 |
Twenty-four-hour intragastric acidity following early evening or bedtime administration of roxatidine in duodenal ulcer patients.
Topics: Administration, Oral; Adult; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; Female; Gastric Acid; Histamine H2 Antagonists; Humans; Male; Middle Aged; Piperidines | 1996 |
Absence of tolerance in duodenal ulcer patients treated for 28 days with a bedtime dose of roxatidine or ranitidine.
Topics: Adult; Analysis of Variance; Drug Tolerance; Duodenal Ulcer; Female; Gastric Acidity Determination; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Piperidines; Prospective Studies; Ranitidine; Single-Blind Method | 1996 |
[The volume and pH of gastric fluid in elective surgical patients after preoperative oral fluid intake].
Topics: Adolescent; Adult; Aged; Drinking; Elective Surgical Procedures; Female; Gastric Juice; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Piperidines; Preoperative Care; Risk Factors; Time Factors | 1996 |
Roxatidine versus ranitidine in the treatment of duodenal ulcer: a randomized, double blind, controlled, multicenter study in Thailand.
Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Drug Administration Schedule; Duodenal Ulcer; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Pain Measurement; Piperidines; Ranitidine; Risk Factors; Thailand; Treatment Outcome | 1995 |
The role of gastric acid and Helicobacter pylori in the natural course of duodenal ulcer.
Topics: Adolescent; Adult; Aged; Aluminum Hydroxide; Drug Combinations; Duodenal Ulcer; Female; Gastric Acid; Helicobacter pylori; Humans; Magnesium Hydroxide; Male; Middle Aged; Piperidines; Prospective Studies; Recurrence; Simethicone | 1999 |
[Clinical evaluation of roxatidine acetate hydrochlorides as a preanesthetic medication].
Topics: Adult; Age Factors; Aged; Anesthesia, General; Bronchial Spasm; Delayed-Action Preparations; Depression, Chemical; Female; Gastric Acid; Histamine H2 Antagonists; Humans; Intraoperative Complications; Male; Middle Aged; Piperidines; Pneumonia, Aspiration; Preanesthetic Medication | 2001 |
Influence of lansoprazole, famotidine, roxatidine and rebamipide administration on the urea breath test for the diagnosis of Helicobacter pylori infection.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Alanine; Anti-Ulcer Agents; Breath Tests; False Negative Reactions; Famotidine; Female; Helicobacter Infections; Helicobacter pylori; Humans; Lansoprazole; Male; Omeprazole; Piperidines; Predictive Value of Tests; Quinolones; Urea | 2003 |
A proton pump inhibitor, lansoprazole, ameliorates asthma symptoms in asthmatic patients with gastroesophageal reflux disease.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Aged; Asthma; Drug Evaluation; Female; Forced Expiratory Volume; Gastroesophageal Reflux; Humans; Lansoprazole; Male; Middle Aged; Omeprazole; Peak Expiratory Flow Rate; Piperidines; Prospective Studies; Proton Pump Inhibitors; Surveys and Questionnaires | 2006 |
Efficacy of a single 24-hour pre-anesthetic dose of proton pump inhibitors.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Aged; Drug Administration Schedule; Female; Gastric Acidity Determination; Histamine H2 Antagonists; Humans; Lansoprazole; Male; Middle Aged; Piperidines; Pneumonia, Aspiration; Preanesthetic Medication; Proton Pump Inhibitors; Rabeprazole; Respiratory Aspiration; Risk Factors; Treatment Outcome; Urologic Surgical Procedures | 2009 |
Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anti-Ulcer Agents; Cost-Benefit Analysis; Dissection; Female; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastroscopy; Humans; Lansoprazole; Male; Middle Aged; Pilot Projects; Piperidines; Postoperative Complications; Prospective Studies; Stomach Neoplasms; Stomach Ulcer; Treatment Outcome | 2011 |
Early effects of oral administration of omeprazole and roxatidine on intragastric pH.
Topics: Adult; Cross-Over Studies; Gastric Acid; Gastric Acidity Determination; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Omeprazole; Piperidines; Proton Pump Inhibitors; Young Adult | 2012 |
Pharmacokinetics of the H(2) blocker roxatidine acetate hydrochloride in pediatric patients, in comparison with healthy adult volunteers.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Anti-Ulcer Agents; Area Under Curve; Body Surface Area; Body Weight; Capsules; Child; Drug Dosage Calculations; Female; Histamine H2 Antagonists; Humans; Japan; Male; Metabolic Clearance Rate; Models, Biological; Piperidines; Reproducibility of Results | 2012 |
Effects of oral rehydration therapy on gastric volume and pH in patients with preanesthetic H2 antagonist.
Topics: Adult; Aged; Aged, 80 and over; Anesthesia, General; Fasting; Female; Fluid Therapy; Gastric Acidity Determination; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Piperidines; Pneumonia, Aspiration; Preoperative Care; Stomach; Young Adult | 2012 |
Pharmacokinetics and Bioequivalence Studies of Roxatidine Acetate Hydrochloride Sustained-Release Capsule in Healthy Chinese Subjects.
Topics: Area Under Curve; Capsules; China; Cross-Over Studies; Delayed-Action Preparations; Drugs, Generic; Healthy Volunteers; Humans; Piperidines; Tablets; Therapeutic Equivalency | 2022 |
68 other study(ies) available for roxatidine acetate and piperidines
| Article | Year |
|---|---|
[Effects of IGN-2098, a new histamine H2-receptor antagonist, on gastric secretion and gastric and duodenal lesions induced in rats. Comparison with roxatidine].
Topics: Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Duodenal Ulcer; Gastric Juice; Histamine H2 Antagonists; Male; Piperidines; Pyrimidinones; Rats; Rats, Inbred Strains; Stomach Ulcer | 1992 |
Effects of a new histamine H2-receptor antagonist, Z-300, on gastric secretion and gastro-duodenal lesions in rats: comparison with roxatidine.
Topics: Acetamides; Administration, Oral; Animals; Dogs; Duodenum; Female; Gastric Acid; Gastric Mucosa; Histamine H2 Antagonists; Male; Peptic Ulcer; Piperidines; Rats; Rats, Inbred Strains; Stomach; Stomach Ulcer | 1992 |
Effects of H2-receptor blockers on response of cerebral blood flow to normocapnic hypoxia.
Topics: Animals; Cerebrovascular Circulation; Dogs; Famotidine; Hemodynamics; Histamine H2 Antagonists; Hypoxia; Injections, Intravenous; Microspheres; Piperidines; Pulmonary Gas Exchange; Ranitidine; Respiration | 1991 |
[The effect of oral administration of roxatidine acetate hydrochloride 3 hours prior to the operation on pH and volume of gastric juice].
Topics: Administration, Oral; Adolescent; Adult; Aged; Female; Gastric Juice; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Piperidines; Surgical Procedures, Operative | 1991 |
Effect of a new H2-receptor antagonist (roxatidine acetate) on the acid secretion by isolated canine parietal cells.
Topics: Animals; Dogs; Gastric Acid; Histamine H2 Antagonists; In Vitro Techniques; Parietal Cells, Gastric; Piperidines | 1989 |
[Effects of different dosages of roxatidine on 24 hrs intragastric pH].
Topics: Adult; Dose-Response Relationship, Drug; Duodenal Ulcer; Female; Gastric Acidity Determination; Histamine H2 Antagonists; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Monitoring, Physiologic; Piperidines | 1989 |
The metabolism of roxatidine acetate hydrochloride in rat and dog liver homogenates.
Topics: Animals; Cytochrome P-450 Enzyme System; Dogs; Gas Chromatography-Mass Spectrometry; Histamine H2 Antagonists; In Vitro Techniques; Liver; Male; Microsomes, Liver; Piperidines; Rats; Species Specificity | 1987 |
A comparison of the inhibitory effects of roxatidine acetate hydrochloride and cimetidine on cytochrome P-450-mediated drug-metabolism in mouse hepatic microsomes and in man in vivo.
Topics: Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Histamine H2 Antagonists; Humans; Inactivation, Metabolic; Isoenzymes; Kinetics; Mice; Microsomes, Liver; Piperidines; Steroid 16-alpha-Hydroxylase | 1987 |
Symposium on roxatidine acetate. Rottach-Egern, 3-5 June 1987. Proceedings.
Topics: Histamine H2 Antagonists; Humans; Piperidines | 1988 |
Determination of roxatidine in human plasma, urine and milk by capillary gas chromatography using nitrogen-selective detection.
Topics: Chromatography, Gas; Female; Histamine H2 Antagonists; Humans; Indicators and Reagents; Milk, Human; Piperidines | 1988 |
Penetration of roxatidine into the cerebrospinal fluid.
Topics: Animals; Blood-Brain Barrier; Female; Histamine H2 Antagonists; Humans; Male; Middle Aged; Piperidines; Time Factors | 1988 |
Chemical and biologic characteristics of roxatidine acetate.
Topics: Animals; Anti-Ulcer Agents; Chemical Phenomena; Chemistry; Dogs; Endocrine Glands; Gastric Acid; Gastric Mucosa; Guinea Pigs; Histamine H2 Antagonists; Piperidines; Rabbits; Rats | 1988 |
Conformational study of a histamine H2-receptor antagonist: crystal structures of 2-acetoxy-N-[3-[m-(1-piperidinomethyl)phenoxy]propyl]acetamide (roxatidine acetate) and its hydrochloride salt.
Topics: Histamine H2 Antagonists; Molecular Conformation; Piperidines; X-Ray Diffraction | 1988 |
[Therapeutic effect of IGN-2098, a new antiulcer drug (H2-antagonist), in the ulcer diminishing period against acetic acid-induced gastric ulcer in rats].
Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Famotidine; Histamine H2 Antagonists; Male; Piperidines; Pyrimidinones; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 1995 |
Pharmacokinetics and pharmacodynamics of roxatidine in patients with renal insufficiency.
Topics: Adult; Drug Administration Schedule; Female; Gastric Acid; Gastric Acidity Determination; Gastrins; Histamine H2 Antagonists; Humans; Kidney Failure, Chronic; Male; Middle Aged; Parathyroid Hormone; Piperidines | 1995 |
[Roxatidine in the treatment of gastroduodenal mucosal lesions in hepatic cirrhosis].
Topics: Adult; Aged; Duodenal Diseases; Female; Gastric Mucosa; Histamine H2 Antagonists; Humans; Intestinal Mucosa; Liver Cirrhosis; Male; Middle Aged; Piperidines; Stomach Diseases | 1994 |
Endoscopic ultrasonographic evaluation of gastric ulcer healing on treatment with proton pump inhibitors versus H2-receptor antagonists.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Ulcer Agents; Famotidine; Female; Gastroscopy; Histamine H2 Antagonists; Humans; Lansoprazole; Male; Middle Aged; Nizatidine; Omeprazole; Piperidines; Proton Pump Inhibitors; Stomach Ulcer; Ultrasonography, Interventional; Wound Healing | 1994 |
[Effects of various histamine H2-receptor antagonists on gastrointestinal motility and gastric emptying].
Topics: Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Famotidine; Gastric Emptying; Gastrointestinal Motility; Histamine H2 Antagonists; Nizatidine; Piperidines; Ranitidine | 1993 |
Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy] propyl] urea.
Topics: Animals; Cerebral Cortex; Cimetidine; Dogs; Famotidine; Food; Gastric Acid; Guinea Pigs; Heart Atria; Heart Rate; Histamine H2 Antagonists; In Vitro Techniques; Kinetics; Male; Phenylurea Compounds; Piperidines; Pylorus; Rats; Rats, Wistar; Tetragastrin | 1993 |
Healing-promoting action of the new histamine H2-receptor antagonist N-ethyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl]urea with dual action on chronic gastric and duodenal ulcers induced by acetic acid in rats.
Topics: Acetates; Animals; Anti-Ulcer Agents; Dose-Response Relationship, Drug; Duodenal Ulcer; Famotidine; Gastric Mucosa; Histamine H2 Antagonists; Intestinal Mucosa; Male; Phenylurea Compounds; Piperidines; Rats; Rats, Wistar; Stomach Ulcer | 1993 |
Effect of omeprazole, an inhibitor of H+,K(+)-ATPase, on bone resorption in humans.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Biomarkers; Body Weight; Bone Resorption; Calcium; Child; Cimetidine; Female; Histamine H2 Antagonists; Humans; Hydroxyproline; Male; Middle Aged; Omeprazole; Osteocalcin; Piperidines; Proton Pump Inhibitors; Stomach Ulcer | 1993 |
Effect of the novel histamine H2-antagonist 5,6-dimethyl-2-[4-[3-(1- piperidinomethyl)phenoxy]-(z)-2-butenylamino]-4(1H)-pyrimidine dihydrochloride on histamine-induced gastric acid secretion in Heidenhain pouch dogs.
Topics: Administration, Oral; Animals; Cimetidine; Dogs; Dose-Response Relationship, Drug; Famotidine; Gastric Acid; Gastric Mucosa; Histamine; Histamine H2 Antagonists; Injections, Intravenous; Male; Piperidines; Pyrimidinones | 1993 |
Drug interactions between theophylline and H2-antagonists, roxatidine acetate hydrochloride and cimetidine: pharmacokinetic analysis in rats in vivo.
Topics: Animals; Bronchodilator Agents; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Half-Life; Histamine H2 Antagonists; Male; Piperidines; Rats; Rats, Wistar; Spectrophotometry, Ultraviolet; Theophylline | 1995 |
Histamine H2-receptor antagonists stimulate proliferation but not migration of human gastric mucosal cells in vitro.
Topics: Adenocarcinoma; Blotting, Northern; Cell Division; Cell Movement; Dose-Response Relationship, Drug; ErbB Receptors; Gastric Mucosa; Histamine H2 Antagonists; Humans; Piperidines; Ranitidine; RNA, Messenger; RNA, Neoplasm; Stimulation, Chemical; Stomach Neoplasms; Time Factors; Transforming Growth Factor alpha; Tumor Cells, Cultured | 1996 |
Synthesis, gastroprotective, antisecretory and anti-Helicobacter effect of N-[3-(3-(1-piperidinylmethyl) phenoxy)propyl]-hydroxyacetamide 2-hydroxypropane-1,2,3-tricarboxylate bismuth (3+) complex (MX1)-MX1.
Topics: Animals; Anti-Ulcer Agents; Ethanol; Female; Gastric Mucosa; Helicobacter pylori; Histamine; Male; Microbial Sensitivity Tests; Organometallic Compounds; Piperidines; Rats; Rats, Wistar; Stomach Ulcer; Tricarboxylic Acids | 1996 |
[Roxatidine acetate in therapy of reflux esophagitis].
Topics: Anti-Ulcer Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Esophagoscopy; Female; Gastroesophageal Reflux; Humans; Male; Middle Aged; Piperidines | 1996 |
A histamine H2 receptor antagonist, roxatidine, stimulates mucus secretion and synthesis by cultured rabbit gastric mucosal cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Histamine H2 Antagonists; Indomethacin; Male; Mucus; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Rabbits | 1995 |
Lichenoid eruptions due to the H2-receptor antagonists roxatidine and ranitidine.
Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Drug Eruptions; Female; Histamine H2 Antagonists; Humans; Lichenoid Eruptions; Piperidines; Ranitidine; Stomach Ulcer | 1996 |
Different effects of H1 and H2 blockers on the tone and the contractile activity of guinea pig stomach fundus.
Topics: Acetylcholine; Animals; Cimetidine; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Muscle, Smooth; Piperidines; Ranitidine; Stomach | 1995 |
Synthesis and biological evaluation of a new reversely linked type of dual histamine H2 and gastrin receptor antagonist.
Topics: Animals; Anti-Ulcer Agents; Benzodiazepines; Drug Design; Famotidine; Gastric Acid; Histamine H2 Antagonists; Molecular Weight; Piperidines; Rats; Receptors, Cholecystokinin | 1997 |
Drug-related low responsiveness to recombinant human erythropoietin therapy in three patients with end-stage renal disease.
Topics: Aged; Allopurinol; Anemia; Captopril; Drug Interactions; Drug Resistance; Erythropoietin; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Piperidines; Recombinant Proteins | 1997 |
Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with decreased hydrophobicity.
Topics: Animals; Benzodiazepines; Chemical Phenomena; Chemistry, Physical; Gastric Acid; Gastrins; Guinea Pigs; Histamine H2 Antagonists; In Vitro Techniques; Mice; Piperidines; Rats; Receptors, Cholecystokinin; Solubility; Structure-Activity Relationship | 1997 |
Gastroprotective effect of MX1 (a novel salt of the active metabolite of roxatidine with a complex of bismuth and citric acid) against stress ulcers in rats.
Topics: Animals; Antacids; Anti-Ulcer Agents; Drug Combinations; Gastric Mucosa; Histamine H2 Antagonists; Male; Organometallic Compounds; Peptic Ulcer; Piperidines; Rats; Rats, Wistar; Restraint, Physical | 1997 |
Structural requirements for roxatidine in the stimulant effect of rat gastric mucin synthesis and the participation of nitric oxide in this mechanism.
Topics: Animals; Benzoates; Enzyme Inhibitors; Free Radical Scavengers; Gastric Mucosa; Histamine H2 Antagonists; Imidazoles; Male; Mucins; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Piperidines; Ranitidine; Rats; Rats, Wistar; Receptors, Histamine H2 | 1997 |
Roles of extracellular Ca++ and calmodulin in roxatidine-stimulated secretion and synthesis of mucus by cultured rabbit gastric mucosal cells.
Topics: Animals; Calcium; Calmodulin; Cells, Cultured; Diltiazem; Gastric Mucosa; Histamine H2 Antagonists; Male; Mucus; Nifedipine; Piperidines; Rabbits; Sulfonamides | 1998 |
Structure-activity characterization of an H2-receptor antagonist, 3-amino-4-[4-[4-(1-piperidinomethyl)-2-pyridyloxy]-cis-2-++ +butenylamino]- 3-cyclobutene-1,2-dione hydrochloride (T-066), involved in the insurmountable antagonism against histamine-induce
Topics: Animals; Guinea Pigs; Heart Atria; Heart Rate; Histamine; Histamine H2 Antagonists; In Vitro Techniques; Male; Molecular Structure; Piperidines; Pyridines; Structure-Activity Relationship; Triazoles | 1998 |
A novel histamine 2(H2) receptor antagonist with gastroprotective activity. I. Synthesis and pharmacological evaluation of N-phenoxypropylacetamide derivatives with thioether function.
Topics: Acetamides; Administration, Oral; Animals; Anti-Ulcer Agents; Benzothiazoles; Calcium Channel Blockers; Gastric Acid; Histamine H2 Antagonists; Male; Perfusion; Piperidines; Rats; Rats, Wistar; Stomach; Structure-Activity Relationship; Sulfides; Thiazoles | 1998 |
Combined histamine H1/H2 receptor antagonists: part I. Pharmacological hybrids with pheniramine- and roxatidine-like substructures.
Topics: Animals; Dose-Response Relationship, Drug; Guinea Pigs; Heart Atria; Histamine H1 Antagonists; Histamine H2 Antagonists; Ileum; In Vitro Techniques; Male; Pheniramine; Piperidines; Structure-Activity Relationship | 1998 |
Biopharmaceutical characterization of oral controlled/modified-release drug products. In vitro/in vivo correlation of roxatidine.
Topics: Administration, Oral; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Delayed-Action Preparations; Histamine H2 Antagonists; Humans; Piperidines | 1998 |
Stimulant effect of nitric oxide generator and roxatidine on mucin biosynthesis of rat gastric oxyntic mucosa.
Topics: Animals; Culture Techniques; Gastric Mucosa; Glucosamine; Histamine H2 Antagonists; Immunoenzyme Techniques; Isosorbide Dinitrate; Male; Mucins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Piperidines; Rats; Rats, Wistar | 1999 |
Inhibitory effects of H2-receptor antagonists on platelet function in vitro.
Topics: Adenosine Diphosphate; Adult; Arachidonic Acid; Aspirin; Blood Platelets; Cimetidine; Collagen; Famotidine; Female; Heterocyclic Compounds, 1-Ring; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Middle Aged; P-Selectin; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Ranitidine; Structure-Activity Relationship | 1999 |
Erythema multiforme caused by the H2-blocker, roxatidine.
Topics: Adult; Arm; Diagnosis, Differential; Drug Eruptions; Erythema Multiforme; Female; Histamine H2 Antagonists; Humans; Neck; Piperidines | 2000 |
Suppressive effect of antiulcer agents on granulocytes--a role for granulocytes in gastric ulcer formation.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Animals; Anti-Ulcer Agents; Depression, Chemical; Granulocytes; Histamine H2 Antagonists; Humans; Lansoprazole; Leukocyte Count; Luminescent Measurements; Mice; Middle Aged; Omeprazole; Piperidines; Proton Pump Inhibitors; Stomach Ulcer; Stress, Physiological; Superoxides | 2000 |
Pharmacokinetics of roxatidine acetate in patients with chronic liver disease.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Chronic Disease; Creatinine; Half-Life; Hepatitis C, Chronic; Histamine H2 Antagonists; Humans; Liver Cirrhosis; Liver Function Tests; Metabolic Clearance Rate; Middle Aged; Peptic Ulcer; Piperidines | 2001 |
Cytochrome P450 enzymes involved in the metabolic pathway of the histamine 2 (H2)-receptor antagonist roxatidine acetate by human liver microsomes.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Histamine H2 Antagonists; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Lymphatic System; Microsomes, Liver; Piperidines; Spectrophotometry, Ultraviolet; Subcellular Fractions | 2001 |
Serum pepsinogen can predict response to H2-receptor antagonist in patients with functional dyspepsia.
Topics: Adult; Aged; Anti-Ulcer Agents; Biomarkers; Dyspepsia; Female; Gastrins; Helicobacter pylori; Histamine H2 Antagonists; Humans; Male; Middle Aged; Patient Selection; Pepsinogen A; Pepsinogen C; Piperidines; Treatment Outcome | 2002 |
Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice.
Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cimetidine; Colonic Neoplasms; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Piperidines; Xenograft Model Antitumor Assays | 2003 |
Complexation of roxatidine acetate hydrochloride with beta-cyclodextrin: NMR spectroscopic study.
Topics: Anti-Ulcer Agents; beta-Cyclodextrins; Cyclodextrins; Deuterium Oxide; Excipients; Magnetic Resonance Spectroscopy; Piperidines | 2004 |
Regular use of H2 blockers reduces the efficacy of roxatidine to control gastric pH and volume.
Topics: Aged; Anesthesia; Bile; Drug Tolerance; Enzyme-Linked Immunosorbent Assay; Female; Gastric Acid; Gastric Acidity Determination; Gastrins; Histamine H2 Antagonists; Histamine Release; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Piperidines; Preanesthetic Medication; Stomach | 2005 |
Stability of roxatidine acetate in parenteral nutrient solutions containing different amino acid formulations.
Topics: Amino Acids; Chemistry, Pharmaceutical; Drug Stability; Histamine H2 Antagonists; Parenteral Nutrition; Piperidines; Solutions | 2005 |
Erythrodermic drug eruption due to roxatidine acetate hydrochloride.
Topics: Dermatitis, Exfoliative; Drug Eruptions; Histamine H2 Antagonists; Humans; Male; Middle Aged; Piperidines | 2005 |
The efficacy of preanesthetic proton pump inhibitor treatment for patients on long-term H2 antagonist therapy.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Anti-Ulcer Agents; Benzimidazoles; Drug Tolerance; Famotidine; Female; Gastric Acidity Determination; Gastrins; Histamine H2 Antagonists; Humans; Male; Middle Aged; Omeprazole; Piperidines; Pneumonia, Aspiration; Preanesthetic Medication; Proton Pump Inhibitors; Rabeprazole | 2005 |
Histamine regulates growth of malignant melanoma implants via H2 receptors in mice.
Topics: Administration, Oral; Animals; Cell Line, Tumor; Cell Proliferation; Cimetidine; Dose-Response Relationship, Drug; Gene Expression; Histamine; Histamine Agents; Histamine H2 Antagonists; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Piperidines; Receptors, Histamine H2; RNA, Messenger | 2005 |
Determination of roxatidine in human plasma by liquid chromatography/electrospray mass spectrometry and application to a clinical pharmacokinetic study.
Topics: Administration, Oral; Adult; Anti-Ulcer Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Humans; Male; Metabolic Clearance Rate; Microchemistry; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2007 |
Does long-term medication with a proton pump inhibitor induce a tolerance to H2 receptor antagonist?
Topics: Drug Tolerance; Female; Gastric Acid; Gastric Acidity Determination; Histamine H2 Antagonists; Humans; Male; Middle Aged; Piperidines; Pneumonia, Aspiration; Proton Pump Inhibitors; Time Factors | 2007 |
Quantification of roxatidine in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry: application to a bioequivalence study.
Topics: Drug Stability; Humans; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Therapeutic Equivalency | 2008 |
Phenoxypropylamines: synthesis and antiulcer evaluation.
Topics: Amines; Animals; Anti-Ulcer Agents; Gastric Acid; Guinea Pigs; Histamine H2 Antagonists; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Piperidines | 2009 |
Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Famotidine; Histamine H2 Antagonists; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Mucus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptic Ulcer; Piperidines; Prostaglandins; Rats; Rats, Sprague-Dawley | 2010 |
Roxatidine, an H(2) receptor blocker, is an estrogenic compound--experimental evidence.
Topics: Animals; Estrogens; Female; Histamine H2 Antagonists; Organ Size; Ovariectomy; Piperidines; Rabbits; Rats; Rats, Wistar; Uterus | 2010 |
Anti-ovulatory activity of H2 receptor blockers in albino rabbits--a preliminary study.
Topics: Administration, Oral; Animals; Contraceptive Agents; Dose-Response Relationship, Drug; Famotidine; Female; Histamine H2 Antagonists; Histamine Release; Ovulation; Piperidines; Rabbits; Random Allocation; Ranitidine | 2011 |
Psoriasiform eruption localized to a previously irradiated area.
Topics: Carcinoma; Chemotherapy, Adjuvant; Drug Eruptions; Histamine H2 Antagonists; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Piperidines; Psoriasis; Radiodermatitis; Radiotherapy, Adjuvant; Tongue Neoplasms | 2011 |
Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.
Topics: Animals; Cell Line; Electrophoretic Mobility Shift Assay; Histamine H2 Antagonists; Humans; Inflammation; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Piperidines; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Investigation of the binding of roxatidine acetate hydrochloride with cyclomaltoheptaose (β-cyclodextrin) using IR and NMR spectroscopy.
Topics: beta-Cyclodextrins; Magnetic Resonance Spectroscopy; Molecular Structure; Piperidines; Spectroscopy, Fourier Transform Infrared | 2011 |
Different effects of two types of H2-receptor antagonists, famotidine and roxatidine, on the mucus barrier of rat gastric mucosa.
Topics: Animals; Anti-Ulcer Agents; Famotidine; Gastric Mucins; Gastric Mucosa; Histamine H2 Antagonists; Male; Mucus; Piperidines; Rats; Rats, Wistar | 2012 |
Synthesis and dual histamine H₁ and H₂ receptor antagonist activity of cyanoguanidine derivatives.
Topics: Animals; Cimetidine; Guanidines; Guinea Pigs; Histamine H1 Antagonists; Histamine H2 Antagonists; Magnetic Resonance Spectroscopy; Male; Molecular Structure; Piperidines; Pyrilamine | 2013 |
Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation.
Topics: Animals; Caspase 1; Cell Line; Cytokines; Deoxyribonucleases, Type II Site-Specific; Enzyme Activation; Histamine H2 Antagonists; Humans; Hypersensitivity; Inflammation Mediators; Male; Mast Cells; Mice; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Piperidines | 2017 |
Roxatidine Attenuates Degradation of Extracellular Matrix.
Topics: ADAMTS Proteins; Cell Line, Tumor; Collagen Type II; Extracellular Matrix; Humans; Matrix Metalloproteinase 13; Matrix Metalloproteinase 3; Nitric Oxide; Nitric Oxide Synthase Type II; Piperidines; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2017 |
Roxatidine inhibits fibrosis by inhibiting NF‑κB and MAPK signaling in macrophages sensing breast implant surface materials.
Topics: Animals; Breast Implants; Female; Fibroblasts; Fibrosis; Humans; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Piperidines; RAW 264.7 Cells; Surface Properties | 2020 |