rotenone and paraquat
rotenone has been researched along with paraquat in 69 studies
Research
Studies (69)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.80) | 18.7374 |
| 1990's | 3 (4.35) | 18.2507 |
| 2000's | 22 (31.88) | 29.6817 |
| 2010's | 33 (47.83) | 24.3611 |
| 2020's | 7 (10.14) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Hirai, K; Ikeda, K; Wang, GY | 1 |
| John, RA; Oreffo, VI; Richards, RJ | 1 |
| Blondin, GA; Harkin, JM; Knobeloch, LM; Lyford, SB | 1 |
| Fridovich, I; Liochev, S | 1 |
| Rose, MS; Smith, LL; Wyatt, I | 2 |
| Smith, LL; Wyatt, I | 1 |
| Fink, AL; Li, J; Uversky, VN | 1 |
| Di Monte, DA | 1 |
| Uversky, VN | 1 |
| Armstrong-Gold, CE; Bonini, NM; Heutink, P; Meulener, M; Pallanck, LJ; Rizzu, P; Wes, PD; Whitworth, AJ | 1 |
| Greenamyre, JT; Miller, GW; Quan, Y; Richardson, JR; Sherer, TB | 1 |
| Alfonso, A; Burnam, L; Hoener, M; Liu, L; Perier, C; Przedborski, S; Rodrigues, CM; Saha, S; Sluder, A; Steer, C; Ved, R; Westlund, B; Wolozin, B | 1 |
| Chew, KC; Dawson, TM; Dawson, VL; Ho, MW; Ko, HS; Lim, KL; Lim, TM; Pletnikova, O; Soong, TW; Tay, SP; Thomas, B; Troncoso, J; Tsang, F; Wang, C | 1 |
| Bové, J; Perier, C; Prou, D; Przedborski, S | 1 |
| Barták, M; Ilík, P; Kotabová, E; Schansker, G; Strasser, RJ; Váczi, P | 1 |
| Kordower, JH; O'Malley, J; Soderstrom, K; Steece-Collier, K | 1 |
| German, DC; Liang, CL; Luby-Phelps, K; Wang, TT | 1 |
| Hansen, JM; Jones, DP; Miller, GW; Ramachandiran, S; Richardson, JR | 1 |
| Bandez, MJ; Gomez, C; Navarro, A | 1 |
| Choi, WS; Faigle, R; Klintworth, H; Li, T; Newhouse, K; Xia, Z | 1 |
| Cavada, C; Cuadrado, A; de Sagarra, MR; Rojo, AI | 1 |
| James-Kracke, M; Miller, RL; Sun, AY; Sun, GY | 1 |
| Bellezza, I; Bolaños, JP; Cacciatore, I; Conte, C; Grottelli, S; Minelli, A | 1 |
| Buffenstein, R; Miller, RA; Sadighi Akha, AA; Salmon, AB | 1 |
| Choi, WS; Kruse, SE; Palmiter, RD; Xia, Z | 1 |
| Garden, G; Klintworth, H; Xia, Z | 1 |
| Chan, D; Cookson, M; Ferree, A; Ghosh, J; Goldstein, L; Guillily, MD; Hisamoto, N; Hsu, CH; Iwatsubo, T; Kuwahara, T; Lanceta, J; Matsumoto, K; Moore, L; Raghavan, K; Saha, S; Segal, L; Wolozin, B | 1 |
| Cicchetti, F; Drouin-Ouellet, J; Gross, RE | 1 |
| Abel, G; Choi, WS; Flavell, RA; Klintworth, H; Xia, Z | 1 |
| Kim, G; Levine, RL; Liu, C; Zhao, H | 1 |
| Cannon, JR; Greenamyre, JT | 1 |
| Bhudhikanok, GS; Blair, A; Cambi, F; Chade, AR; Comyns, K; Fernandez, HH; Goldman, SM; Hoppin, JA; Kamel, F; Kasten, M; Korell, M; Langston, JW; Marras, C; Meng, C; Priestley, B; Richards, MB; Ross, GW; Sandler, DP; Tanner, CM; Umbach, DM | 1 |
| Colosio, C; Moretto, A | 1 |
| Spivey, A | 1 |
| Choi, WS; Klintworth, HM; Xia, Z | 1 |
| Bové, J; Perier, C | 1 |
| Tieu, K | 1 |
| Henderson, GI; Mahimainathan, L; Narasimhan, M; Rathinam, ML; Riar, AK; Watts, LT | 1 |
| Dranka, BP; Kalyanaraman, B; Kanthasamy, AG; Zielonka, J | 1 |
| Andrieu, T; Baron, T; Bétemps, D; Chorfa, A; Hogeveen, K; Lazizzera, C; Morignat, E | 1 |
| Lenaers, G; Reynier, P; Thany, SH | 1 |
| Au-Yeung, W; Li, PP; Roedding, AS; Tong, SY; Warsh, JJ | 1 |
| Gu, J; Jiang, H; Jin, Y; Shen, N; Tang, Y; Zhou, Y | 1 |
| Kamel, F | 1 |
| Anandhan, A; Burns, M; Chen, H; Franco, R; Garcia-Garcia, A; Zhou, Y | 1 |
| De Clercq, I; Inzé, A; Ivanova, A; Jaspers, P; Kangasjärvi, J; Law, SR; Murcha, MW; Ng, S; Rombaut, D; Van Aken, O; Van Breusegem, F; van de Cotte, B; Van de Peer, Y; Vandepoele, K; Vermeirssen, V; Whelan, J | 1 |
| Dagda, RK; Das Banerjee, T; Janda, E | 1 |
| Miller, GW; Qi, Z; Voit, EO | 1 |
| Armstrong, SM; Moore, C; Willis, GL | 1 |
| Dodds, ED; Franco, R; Garcia-Garcia, A; Huang, Y; Lei, S; Madayiputhiya, N; Nandakumar, R; Powers, R; Stanton, RC; Zavala-Flores, L | 1 |
| de Souza, TL; Follmer, C; Maturana, MG; Pinheiro, AS | 1 |
| Bhudhikanok, GS; Blair, A; Chade, A; Comyns, K; Furlong, M; Goldman, SM; Hoppin, JA; Kamel, F; Kasten, M; Korell, M; Langston, JW; Marras, C; Meng, C; Richards, M; Ross, GW; Sandler, DP; Tanner, CM; Umbach, DM | 1 |
| Chan, HM; Mailloux, RJ; Yumvihoze, E | 1 |
| Glover, LA; Lagido, C; McLaggan, D | 1 |
| Rajini, PS; Rao, SV; Yenisetti, SC | 1 |
| Dikalova, YV; Khudoerkov, RM; Sheloukhova, LI; Voronkov, DN | 1 |
| Fleming, SM | 1 |
| He, D; Lei, L; Liu, M; Lou, D; Lu, S; Shi, Y; Song, Y; Wang, Z; Wu, S | 1 |
| Hartley, RC; Murphy, MP; Oliveira, JMA; Pinho, BR; Reis, SD | 1 |
| Freeman, JL; Wasel, O | 1 |
| Afiyatullov, SS; Chingizova, EA; Girich, EV; Menchinskaya, ES; Ngoc, NTD; Pislyagin, EA; Pivkin, MV; Popov, RS; Smetanina, OF; Trinh, PTH; Yurchenko, AN; Yurchenko, EA | 1 |
| Cai, X; Liang, Y; Lin, Q; Liu, J; Wu, J; Zhang, S | 1 |
| Albrecht, W; Beltman, JB; Braun, TS; Brecklinghaus, T; Hengstler, JG; Kamp, H; Leist, M; Marangoz, S; Rau, C; Schildknecht, S; Spegg, V; van de Water, B; Vlasveld, M; Wijaya, LS | 1 |
| Anantharam, V; Bargues-Carot, A; Huang, M; Jin, H; Kanthasamy, A; Kanthasamy, AG; Riaz, Z; Wickham, H; Zenitsky, G | 1 |
| Chovsepian, A; Dening, Y; Dieterich, M; Dirscherl, P; Falkai, P; Giese, A; Giesert, F; Herms, J; Khairnar, A; Levin, J; Pan-Montojo, F; Ruf, V; Schmidt, F; Stievenard, A; Straßl, T; Weisenhorn, DV; Wurst, W | 1 |
| Chandramohan, V; Chithra, Y; Dey, G; Ghose, V; Gowthami, N; Srinivas Bharath, MM; Vasudev, V | 1 |
Reviews
15 review(s) available for rotenone and paraquat
| Article | Year |
|---|---|
The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins?
Topics: alpha-Synuclein; Animals; Corpus Striatum; Environmental Exposure; Herbicides; Humans; Insecticides; Intracellular Signaling Peptides and Proteins; Nerve Tissue Proteins; Neurotoxins; Oncogene Proteins; Paraquat; Parkinson Disease; Protein Deglycase DJ-1; Risk Factors; Rotenone; Synucleins; Twin Studies as Topic | 2003 |
Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration.
Topics: Animals; Disease Models, Animal; Fungicides, Industrial; Herbicides; Maneb; Nerve Degeneration; Neurotoxins; Paraquat; Parkinson Disease; Rotenone; Uncoupling Agents | 2004 |
Toxin-induced models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Dopamine Agents; Herbicides; Humans; Neurotoxins; Oxidative Stress; Oxidopamine; Paraquat; Parkinson Disease, Secondary; Rotenone; Sympatholytics | 2005 |
Neural repair strategies for Parkinson's disease: insights from primate models.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Cell Transplantation; Deep Brain Stimulation; Disease Models, Animal; Fungicides, Industrial; Glial Cell Line-Derived Neurotrophic Factor; Herbicides; Humans; Maneb; Nerve Degeneration; Oxidopamine; Paraquat; Parkinson Disease; Pesticides; Primates; Rotenone | 2006 |
Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome.
Topics: Animals; Free Radicals; Humans; Mitochondria; Nitric Oxide; Paraquat; Parkinson Disease, Secondary; Pesticides; Pyridazines; Rats; Rotenone | 2007 |
Oxidative and inflammatory pathways in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Herbicides; Humans; Inflammation; Lipopolysaccharides; Microglia; Mitogen-Activated Protein Kinases; NADPH Oxidases; Neurotoxins; Nitric Oxide Synthase; Oxidative Stress; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Kinase C; Rotenone | 2009 |
Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models?
Topics: Animals; Disease Models, Animal; Environmental Exposure; Humans; Maneb; Paraquat; Parkinson Disease, Secondary; Pesticides; Rotenone | 2009 |
Neurotoxic in vivo models of Parkinson's disease recent advances.
Topics: Animals; Disease Models, Animal; Dopamine; Humans; MPTP Poisoning; Neurotoxicity Syndromes; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Rotenone; Sympatholytics; Uncoupling Agents | 2010 |
Biochemical and toxicological evidence of neurological effects of pesticides: the example of Parkinson's disease.
Topics: Animals; Brain; Dieldrin; Dose-Response Relationship, Drug; Humans; Maneb; Neurotoxicity Syndromes; Paraquat; Parkinson Disease; Pesticides; Pyrethrins; Risk Assessment; Risk Factors; Rotenone; Time Factors; Toxicity Tests | 2011 |
Neurotoxin-based models of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cell Death; Disease Models, Animal; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease, Secondary; Rotenone | 2012 |
A guide to neurotoxic animal models of Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Haplorhini; Lewy Bodies; Mice; MPTP Poisoning; Neurotoxins; Oxidopamine; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Rats; Rotenone; Substantia Nigra | 2011 |
How Parkinsonian toxins dysregulate the autophagy machinery.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Autophagy; Humans; Methamphetamine; Mitophagy; MPTP Poisoning; Neurotoxins; Oxidopamine; Paraquat; Parkinsonian Disorders; Rotenone | 2013 |
Mechanisms of Gene-Environment Interactions in Parkinson's Disease.
Topics: Environmental Exposure; Gene-Environment Interaction; Genetic Predisposition to Disease; Herbicides; Humans; Insecticides; Mutation; Paraquat; Parkinson Disease; Risk Factors; Rotenone | 2017 |
Chemical and Genetic Zebrafish Models to Define Mechanisms of and Treatments for Dopaminergic Neurodegeneration.
Topics: Animals; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Gene Knockdown Techniques; Neurotoxicity Syndromes; Oxidopamine; Paraquat; Parkinson Disease; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Rotenone; Zebrafish; Zebrafish Proteins | 2020 |
Impact of Environmental Risk Factors on Mitochondrial Dysfunction, Neuroinflammation, Protein Misfolding, and Oxidative Stress in the Etiopathogenesis of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; alpha-Synuclein; Animals; DDT; Dieldrin; Herbicides; Humans; Manganese; Mitochondria; Neuroinflammatory Diseases; Neurotoxicity Syndromes; Oxidative Stress; Paraquat; Parkinson Disease; Pesticides; Risk Factors; Rotenone; Trichloroethanes; Vanadium | 2022 |
Other Studies
54 other study(ies) available for rotenone and paraquat
| Article | Year |
|---|---|
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Paraquat damage of rat liver mitochondria by superoxide production depends on extramitochondrial NADH.
Topics: Animals; Benzoquinones; Cytochrome c Group; Free Radicals; Glucose-6-Phosphatase; Glutamates; Glutamic Acid; Malates; Male; Mice; Mice, Inbred ICR; Microscopy, Electron; Mitochondria, Liver; NAD; NADP; Paraquat; Rats; Rats, Inbred Strains; Rotenone; Superoxide Dismutase; Superoxides | 1992 |
Diamine uptake by rat lung type II cells in vitro.
Topics: Animals; Biological Transport; Cells, Cultured; Diamines; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Kinetics; Lung; Ouabain; Paraquat; Potassium Cyanide; Putrescine; Rats; Rotenone; Temperature | 1991 |
A rapid bioassay for chemicals that induce pro-oxidant states.
Topics: 4-Nitroquinoline-1-oxide; Adrenochrome; Animals; Antimycin A; Azo Compounds; Biological Assay; Cattle; Diquat; Doxorubicin; Electron Transport; Mitochondria, Heart; Oxidation-Reduction; Paraquat; Rotenone; Superoxide Dismutase; Toxicology | 1990 |
Superoxide is responsible for the vanadate stimulation of NAD(P)H oxidation by biological membranes.
Topics: Animals; Antimycin A; Intracellular Membranes; Male; Microsomes, Liver; NAD; NADP; Nicotinamide Mononucleotide; Oxidation-Reduction; Paraquat; Rats; Rotenone; Superoxides; Vanadates | 1988 |
Evidence for energy-dependent accumulation of paraquat into rat lung.
Topics: Animals; Carbon Radioisotopes; Diquat; Iodoacetates; Kinetics; Lung; Male; Paraquat; Rats; Rotenone | 1974 |
Factors affecting the efflux of paraquat from rat lung slices.
Topics: Animals; Bromthymol Blue; Glucose; Histamine; In Vitro Techniques; Iodoacetates; Lung; Male; Nitrogen; Oxygen Consumption; Paraquat; Putrescine; Rats; Rotenone | 1981 |
The accumulation of putrescine into slices of rat lung and brain and its relationship to the accumulation of paraquat.
Topics: Animals; Biological Transport; Brain; In Vitro Techniques; Iodoacetates; Kinetics; Lung; Male; Organ Specificity; Paraquat; Putrescine; Rats; Rotenone | 1981 |
Pesticides directly accelerate the rate of alpha-synuclein fibril formation: a possible factor in Parkinson's disease.
Topics: alpha-Synuclein; Circular Dichroism; Dieldrin; Ditiocarb; Nerve Tissue Proteins; Paraquat; Parkinson Disease; Pesticides; Protein Binding; Protein Conformation; Protein Folding; Rotenone; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synucleins | 2001 |
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Blotting, Western; Cluster Analysis; Computational Biology; Crosses, Genetic; Drosophila; Drosophila Proteins; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Neurons; Oxidative Stress; Paraquat; Parkinson Disease; Phylogeny; Protein Deglycase DJ-1; Rotenone; Sequence Alignment; Survival Analysis | 2005 |
Paraquat neurotoxicity is distinct from that of MPTP and rotenone.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Brain; Cell Line, Tumor; Dopamine Agents; Dose-Response Relationship, Drug; Herbicides; Humans; Insecticides; Mitochondria; Neuroblastoma; Neurons; Paraquat; Rotenone; Substrate Specificity | 2005 |
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
Topics: 3-Hydroxybutyric Acid; alpha-Synuclein; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Apoptosis; Benzoates; Benzothiazoles; Bile Acids and Salts; Caenorhabditis elegans; Cholagogues and Choleretics; Copper; Disease Models, Animal; Electron Transport Complex I; Gene Deletion; Gene Expression Regulation; Gene Library; Genetic Techniques; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ions; Iron; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Neurons; Oncogene Proteins; Oxygen Consumption; Paraquat; Parkinson Disease; Polyenes; Probucol; Protein Deglycase DJ-1; Pyrazoles; Pyridazines; RNA, Small Interfering; Rotenone; Sequence Homology, Amino Acid; Sodium Azide; Taurochenodeoxycholic Acid; Thiazoles; Time Factors; Transgenes; Ubiquitin-Protein Ligases | 2005 |
Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Brain; Cells, Cultured; Dopamine; Humans; Hydrogen Peroxide; Male; Mice; Mice, Inbred C57BL; Mutation; Nitric Oxide Donors; Nitroso Compounds; Paraquat; Parkinson Disease; Proteasome Endopeptidase Complex; Reference Values; Rotenone; Solubility; Stress, Physiological; Ubiquitin-Protein Ligases | 2005 |
A dip in the chlorophyll fluorescence induction at 0.2-2 s in Trebouxia-possessing lichens reflects a fast reoxidation of photosystem I. A comparison with higher plants.
Topics: Antimycin A; Chlorophyll; Chlorophyta; Electron Transport; Enzyme Inhibitors; Fluorescence; Lichens; Nigericin; Oxidation-Reduction; Oxidoreductases; Paraquat; Peroxidase; Photosystem I Protein Complex; Pisum sativum; Propyl Gallate; Rotenone; Symbiosis; Thylakoids | 2006 |
Mitochondria mass is low in mouse substantia nigra dopamine neurons: implications for Parkinson's disease.
Topics: Animals; Cell Size; Dendrites; Dopamine; Dopamine Plasma Membrane Transport Proteins; Herbicides; Immunohistochemistry; Male; Mesencephalon; Mice; Microscopy, Confocal; Microscopy, Immunoelectron; Mitochondria; Neurons; Paraquat; Parkinson Disease; Pyridinium Compounds; Rotenone; Substantia Nigra; Uncoupling Agents | 2007 |
Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Herbicides; Humans; Insecticides; JNK Mitogen-Activated Protein Kinases; Mitochondrial Proteins; Neurons; Oxidation-Reduction; Paraquat; Parkinsonian Disorders; Rotenone; Thioredoxins; Transfection | 2007 |
Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis.
Topics: Animals; Apoptosis; Dopamine; Dose-Response Relationship, Drug; Enzyme Activation; Humans; JNK Mitogen-Activated Protein Kinases; Mesencephalon; Neurons; p38 Mitogen-Activated Protein Kinases; Paraquat; PC12 Cells; Pesticides; Rats; Rats, Sprague-Dawley; Rotenone; Signal Transduction; Tyrosine 3-Monooxygenase | 2007 |
Chronic inhalation of rotenone or paraquat does not induce Parkinson's disease symptoms in mice or rats.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Administration, Inhalation; Administration, Intranasal; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Administration Schedule; Herbicides; Insecticides; Male; Mice; Mice, Inbred C57BL; Motor Activity; Nerve Degeneration; Neurons; Paraquat; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Rotenone; Substantia Nigra | 2007 |
Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence.
Topics: Animals; Antioxidants; Apoptosis; Calcium; Cell Survival; Dose-Response Relationship, Drug; Gene Expression; Glutamic Acid; Glutathione; Hydrogen Peroxide; NF-E2-Related Factor 2; Oxidants; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Paraquat; PC12 Cells; Peptides, Cyclic; Phosphorylation; Piperazines; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Rotenone; Time Factors; Up-Regulation | 2009 |
Fibroblasts from naked mole-rats are resistant to multiple forms of cell injury, but sensitive to peroxide, ultraviolet light, and endoplasmic reticulum stress.
Topics: Animals; Cadmium; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Female; Fibroblasts; Glucose; Hot Temperature; Hydrogen Peroxide; Male; Methyl Methanesulfonate; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Mole Rats; Paraquat; Rotenone; Species Specificity; Thapsigargin; Tunicamycin; Ultraviolet Rays | 2008 |
Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.
Topics: Animals; Apoptosis; Dopamine; Gene Deletion; Mice; Mice, Mutant Strains; NADH Dehydrogenase; Neurons; Paraquat; Parkinson Disease; Rotenone | 2008 |
Rotenone and paraquat do not directly activate microglia or induce inflammatory cytokine release.
Topics: Analysis of Variance; Animals; Cells, Cultured; Central Nervous System Agents; Cerebral Cortex; Cytokines; Dose-Response Relationship, Drug; Immunohistochemistry; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Microglia; Nitric Oxide; Paraquat; Rotenone; Time Factors | 2009 |
LRRK2 modulates vulnerability to mitochondrial dysfunction in Caenorhabditis elegans.
Topics: Aging; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Dopamine; Gene Knockdown Techniques; Herbicides; Insecticides; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Mitochondria; Mortality; Mutation; Neurons; Paraquat; Protein Serine-Threonine Kinases; RNA, Messenger; Rotenone | 2009 |
JNK3 mediates paraquat- and rotenone-induced dopaminergic neuron death.
Topics: Animals; Caspase 3; Cell Death; Cells, Cultured; Dopamine; Dose-Response Relationship, Drug; Embryo, Mammalian; Exploratory Behavior; Gene Deletion; Herbicides; Insecticides; Mesencephalon; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 10; Neurons; Oxidative Stress; Paraquat; Phosphorylation; Reaction Time; RNA, Small Interfering; Rotenone; Time Factors; Tyrosine 3-Monooxygenase | 2010 |
Transgenic mice overexpressing methionine sulfoxide reductase A: characterization of embryonic fibroblasts.
Topics: Animals; Cell Survival; Cells, Cultured; Chromium; Embryo, Mammalian; Fibroblasts; Hydrogen Peroxide; Methionine Sulfoxide Reductases; Mice; Mice, Transgenic; Molecular Sequence Data; Oxidative Stress; Paraquat; Rotenone; Thioredoxin-Disulfide Reductase; Thioredoxins | 2010 |
Rotenone, paraquat, and Parkinson's disease.
Topics: Aged; Case-Control Studies; Female; Herbicides; Humans; Insecticides; Iowa; Male; Middle Aged; Mitochondria; North Carolina; Occupational Exposure; Oxidative Stress; Paraquat; Parkinson Disease; Parkinsonian Disorders; Rotenone | 2011 |
Rotenone and paraquat linked to Parkinson's disease: human exposure study supports years of animal studies.
Topics: Herbicides; Humans; Insecticides; Paraquat; Parkinson Disease, Secondary; Rotenone; United States | 2011 |
JNK3-mediated apoptotic cell death in primary dopaminergic neurons.
Topics: Animals; Apoptosis; Caspase 3; Dopaminergic Neurons; Embryo, Mammalian; Enzyme Activation; Female; In Situ Nick-End Labeling; Mesencephalon; Mice; Mitogen-Activated Protein Kinase 10; Paraquat; Phosphorylation; Pregnancy; Primary Cell Culture; Rats; Rats, Sprague-Dawley; RNA Interference; Rotenone; Transfection | 2011 |
Astrocyte mediated protection of fetal cerebral cortical neurons from rotenone and paraquat.
Topics: Animals; Animals, Newborn; Astrocytes; CD13 Antigens; Cell Survival; Cells, Cultured; Cerebral Cortex; Coculture Techniques; Cytoprotection; Dose-Response Relationship, Drug; gamma-Glutamyltransferase; Glutathione; Herbicides; Insecticides; Neurons; Oxidative Stress; Paraquat; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone; Time Factors | 2012 |
Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine Triphosphate; Adrenergic Agents; Animals; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Line, Transformed; Dopamine Agents; Dopaminergic Neurons; Dose-Response Relationship, Drug; Energy Metabolism; Herbicides; Insecticides; Neurotoxins; Oligomycins; Oxidopamine; Oxygen Consumption; Paraquat; Proton Ionophores; Rats; Rotenone; Superoxides; Time Factors | 2012 |
Specific pesticide-dependent increases in α-synuclein levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines.
Topics: alpha-Synuclein; Cell Death; Cell Line, Tumor; Cell Survival; Glycine; Glyphosate; Humans; Insecticides; Maneb; Melanoma; Neuroblastoma; Paraquat; Parkinson Disease; Rotenone; Transduction, Genetic | 2013 |
[Neurotoxicity of pesticides: its relationship with neurodegenerative diseases].
Topics: alpha-Synuclein; Alzheimer Disease; Animals; Genetic Predisposition to Disease; Humans; Insecticides; Mitochondria; Neurodegenerative Diseases; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Rotenone | 2013 |
Chronic oxidative stress modulates TRPC3 and TRPM2 channel expression and function in rat primary cortical neurons: relevance to the pathophysiology of bipolar disorder.
Topics: Animals; Calcium; Calcium Signaling; Cell Survival; Cells, Cultured; Cerebral Cortex; Diglycerides; Dose-Response Relationship, Drug; Embryo, Mammalian; Gene Expression Regulation; Herbicides; Neurons; Oxidative Stress; Paraquat; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rotenone; Time Factors; TRPC Cation Channels; TRPM Cation Channels | 2013 |
MicroRNA-195 targets ADP-ribosylation factor-like protein 2 to induce apoptosis in human embryonic stem cell-derived neural progenitor cells.
Topics: Apoptosis; Base Sequence; Cell Differentiation; Cell Line; Cell Survival; Down-Regulation; Embryonic Stem Cells; GTP-Binding Proteins; Humans; MicroRNAs; Neural Stem Cells; Oligonucleotide Array Sequence Analysis; Paraquat; RNA Interference; Rotenone; Transcriptome | 2013 |
Epidemiology. Paths from pesticides to Parkinson's.
Topics: Amyotrophic Lateral Sclerosis; Animals; Dementia; Environmental Exposure; Humans; Paraquat; Parkinson Disease; Parkinson Disease, Secondary; Pesticides; Risk Factors; Rotenone | 2013 |
Impairment of Atg5-dependent autophagic flux promotes paraquat- and MPP⁺-induced apoptosis but not rotenone or 6-hydroxydopamine toxicity.
Topics: 1-Methyl-4-phenylpyridinium; Apoptosis; Autophagy-Related Protein 5; Caspase 3; Caspase Inhibitors; Cathepsins; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Humans; Microtubule-Associated Proteins; Neurons; Oxidopamine; Paraquat; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Rotenone; Signal Transduction; TOR Serine-Threonine Kinases; Transfection | 2013 |
The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Binding Sites; Cell Nucleus; Endoplasmic Reticulum; Gene Expression Profiling; Gene Expression Regulation, Plant; Mitochondria; Mutation; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Paraquat; Plants, Genetically Modified; Promoter Regions, Genetic; Protein Binding; Regulatory Sequences, Nucleic Acid; Rotenone; Seedlings; Transcription Factors; Transcriptional Activation | 2013 |
Rotenone and paraquat perturb dopamine metabolism: A computational analysis of pesticide toxicity.
Topics: Animals; Computational Biology; Computer Simulation; Dopamine; Humans; Models, Theoretical; Monte Carlo Method; Neurons; Paraquat; Pesticides; Rotenone | 2014 |
Parkinson's disease, lights and melanocytes: looking beyond the retina.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Female; Light; Male; Melanocytes; Motor Activity; Oxidopamine; Paraquat; Parkinson Disease; Rats; Rats, Sprague-Dawley; Retina; Rotenone | 2014 |
Alterations in energy/redox metabolism induced by mitochondrial and environmental toxins: a specific role for glucose-6-phosphate-dehydrogenase and the pentose phosphate pathway in paraquat toxicity.
Topics: 1-Methyl-4-phenylpyridinium; Cell Death; Cell Line, Tumor; Dopamine; Energy Metabolism; Environmental Pollutants; Female; Glucosephosphate Dehydrogenase; Glycolysis; Herbicides; Humans; Magnetic Resonance Spectroscopy; Metabolome; Mitochondria; Oxidation-Reduction; Oxidopamine; Paraquat; Pentose Phosphate Pathway; Rotenone; Spectrometry, Mass, Electrospray Ionization | 2014 |
Unveiling the role of the pesticides paraquat and rotenone on α-synuclein fibrillation in vitro.
Topics: alpha-Synuclein; Animals; Dose-Response Relationship, Drug; Humans; In Vitro Techniques; Microscopy, Electron, Transmission; Nuclear Magnetic Resonance, Biomolecular; Paraquat; Pesticides; Protein Binding; Radioisotopes; Rotenone; Sodium Chloride; Up-Regulation | 2015 |
Protective glove use and hygiene habits modify the associations of specific pesticides with Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Agriculture; Case-Control Studies; Female; Gloves, Protective; Habits; Humans; Iowa; Male; Middle Aged; North Carolina; Occupational Exposure; Occupational Health; Paraquat; Parkinson Disease; Permethrin; Pesticides; Risk; Rotenone; Surveys and Questionnaires; Trifluralin; Workplace | 2015 |
Superoxide produced in the matrix of mitochondria enhances methylmercury toxicity in human neuroblastoma cells.
Topics: Antimycin A; Cell Line, Tumor; Cysteine; Humans; Mercury; Methylmercury Compounds; Mitochondria; Neuroblastoma; Paraquat; Rotenone; Sulfhydryl Compounds; Superoxides | 2015 |
A Screenable In Vivo Assay for Mitochondrial Modulators Using Transgenic Bioluminescent Caenorhabditis elegans.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Drug Evaluation, Preclinical; Enzyme Inhibitors; Luciferases, Firefly; Luminescent Measurements; Mitochondria; Oxaloacetic Acid; Paraquat; Rotenone; Uncoupling Agents | 2015 |
Evidence of neuroprotective effects of saffron and crocin in a Drosophila model of parkinsonism.
Topics: Acetylcholinesterase; Animals; Antioxidants; Biomarkers; Carotenoids; Crocus; Disease Models, Animal; Dopamine; Drosophila melanogaster; Glutathione; Hydrogen Peroxide; Locomotion; Longevity; Mitochondria; Neuroprotective Agents; Nitric Oxide; Oxidative Stress; Paraquat; Parkinsonian Disorders; Phytotherapy; Plant Extracts; Protein Carbonylation; Reactive Oxygen Species; Rotenone; Sulfhydryl Compounds | 2016 |
Quantitative Evaluation of Changes in the Striatal Astrocyte Axons in Simulated Parkinsonism.
Topics: Animals; Astrocytes; Axons; Corpus Striatum; Glial Fibrillary Acidic Protein; Male; Oxidopamine; Paraquat; Parkinsonian Disorders; Rats; Rats, Wistar; Rotenone | 2016 |
Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism.
Topics: Adenosine Triphosphate; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins; Green Fluorescent Proteins; Membrane Potential, Mitochondrial; Membrane Proteins; Microscopy, Electron, Transmission; Mitochondria; Mitochondrial Diseases; Mitochondrial Proteins; Movement; Mutation; Paraquat; Parkinsonian Disorders; Protein Serine-Threonine Kinases; Rotenone | 2018 |
Mitochondrial superoxide generation induces a parkinsonian phenotype in zebrafish and huntingtin aggregation in human cells.
Topics: Animals; Antioxidants; Brain; Humans; Huntingtin Protein; Huntington Disease; Mitochondria; Oxidation-Reduction; Oxidative Stress; Paraquat; Parkinson Disease; Phenotype; Protein Aggregation, Pathological; Reactive Oxygen Species; Rotenone; Superoxides; Tyrosine 3-Monooxygenase; Zebrafish | 2019 |
Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of
Topics: Animals; Antiparkinson Agents; Aspergillus; Cell Line, Tumor; Cell Survival; Mice; Molecular Structure; Neurons; Neuroprotective Agents; Oxidative Stress; Paraquat; Parkinson Disease; Penicillium; Reactive Oxygen Species; Rotenone; Secondary Metabolism; Structure-Activity Relationship; Vietnam | 2020 |
Regulation of secondary metabolite biosynthesis in Monascus purpureus via cofactor metabolic engineering strategies.
Topics: Citrinin; Culture Media; Metabolic Engineering; Monascus; Paraquat; Pigments, Biological; Rotenone; Secondary Metabolism | 2021 |
Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes.
Topics: Anti-Bacterial Agents; Antioxidants; Bortezomib; Glutamate-Cysteine Ligase; Glutathione; Hepatocytes; Humans; NF-E2-Related Factor 2; Nitrofurantoin; Oxidative Stress; Paraquat; Proteasome Inhibitors; RNA, Small Interfering; Rotenone | 2022 |
Toxicity of extracellular alpha-synuclein is independent of intracellular alpha-synuclein.
Topics: alpha-Synuclein; Animals; Dopaminergic Neurons; Mice; Paraquat; Parkinson Disease; Rotenone | 2022 |
Mitochondrial Complex I Inhibition in Dopaminergic Neurons Causes Altered Protein Profile and Protein Oxidation: Implications for Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Cell Death; Dopaminergic Neurons; Electron Transport Complex I; Humans; Paraquat; Parkinson Disease; Proteomics; Rotenone | 2023 |