rotenone and deguelin
rotenone has been researched along with deguelin in 163 studies
Research
Studies (163)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (2.45) | 18.2507 |
| 2000's | 54 (33.13) | 29.6817 |
| 2010's | 91 (55.83) | 24.3611 |
| 2020's | 14 (8.59) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chiba, N; Ohsaki, A; Takashima, J; Yoneda, K | 1 |
| Asao, Y; Matsuda, H; Miyagawa, K; Nakashima, S; Takayama, S; Xu, F; Yoshida, K; Yoshikawa, M | 1 |
| Amoah, BA; Belmain, SR; Kamanula, JF; Nyirenda, SP; Stevenson, PC | 1 |
| Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P | 1 |
| Belofsky, G; Brown, M; Cardenas-Garcia, B; Chen, X; Deardorff, K; Dondji, B; Ferreira, D; Fulkerson, S; Gény, C; Jones, K; McCornack, J; McNutt, S; Ray, W; Winterstein, E | 1 |
| Díaz, A; Ebrahim, W; Hartmann, R; Kalscheuer, R; Kurtán, T; Lin, W; Liu, Z; Mándi, A; Muharini, R; Orfali, RS; Proksch, P; Rehberg, N | 1 |
| Bridges, HR; Hirst, J; Kidd, SL; Mateu, N; Osberger, TJ; Russell, DA; Serreli, R; Sore, HF; Spring, DR | 1 |
| Muhlradt, PF; Sasse, F | 1 |
| Casida, JE; Fang, N; Rowlands, JC | 1 |
| Casida, JE; Rowlands, JC | 1 |
| Casida, JE; Fang, N | 1 |
| Beecher, CW; Kinghorn, AD; Kosmeder, JW; Moon, RC; Moriarty, RM; Pezzuto, JM; Shin, YG; Udeani, GO; Zhao, GM | 1 |
| Kosmeder, JW; Mehta, RG; Murillo, G; Pezzuto, JM; Salti, GI | 1 |
| Kosmeder, JW; Mehta, RG; Murillo, G; Pezzuto, JM | 1 |
| Camps, F; Coll, J; Liu, XQ; Zeng, XN; Zhang, SX | 1 |
| Crowell, JA; Steele, VE | 1 |
| Chun, KH; Hong, WK; Kosmeder, JW; Lee, HY; Lotan, R; Pezzuto, JM; Sun, S | 1 |
| Derese, S; Heydenreich, M; Midiwo, JO; Peter, MG; Yenesew, A | 1 |
| Pastine, SJ; Sames, D | 1 |
| Angioni, A; Cabizza, M; Cabras, M; Cabras, P; Melis, M; Tuberoso, CV | 1 |
| Hong, WK; Kosmeder, JW; Kurie, JM; Lee, HY; Pezzuto, JM; Suh, YA | 1 |
| Hail, N; Lotan, R | 1 |
| Furukawa, H; Ito, C; Itoigawa, M; Kojima, N; Nishino, H; Takayasu, J; Tan, HT; Tokuda, H | 1 |
| Lee, HY | 1 |
| Caboni, P; Casida, JE; Greenamyre, JT; Na, HM; Sherer, TB; Taylor, G; Zhang, N | 1 |
| Connelly, L; Hobbs, AJ; Madhani, M | 1 |
| Derese, S; Heydenreich, M; Induli, M; Kabaru, JM; Koch, A; Midiwo, JO; Mushibe, EK; Peter, MG; Yenesew, A | 1 |
| Billi, AM; Bortul, R; Cappellini, A; Conte, R; Grafone, T; Mantovani, I; Martelli, AM; Martinelli, G; Tabellini, G; Tazzari, PL | 1 |
| Chen, Y; Cui, GH; He, J; Liu, HL; Wu, QL | 1 |
| Gills, JJ; Kosmeder, J; Lantvit, DD; Moon, RC; Pezzuto, JM | 1 |
| Chen, WH; Chen, Y; Cui, GH; He, J; Liu, HL; Wu, QL; Zhou, JF | 1 |
| Angioni, A; Caboni, P; Cabras, P; Garau, VL; Sarais, G | 1 |
| Hecht, SS | 1 |
| Cody, D; Hong, WK; Kim, WY; Lee, HY; Moriarty, RM; Oh, SH; Pezzuto, JM; Price, RE; Tran, H; Van Pelt, CS; Woo, JK | 1 |
| Lubet, RA; Tan, Q; Wang, Y; Yan, Y; You, M | 1 |
| Chen, WH; Chen, Y; Cui, GH | 1 |
| Albini, A; Ambrosini, C; Dell'Eva, R; Ferrari, N; Minghelli, S; Noonan, DM | 1 |
| Aggarwal, BB; Ahn, KS; Kunnumakkara, AB; Nair, AS; Sethi, G; Shishodia, S | 1 |
| Karna, P; Lee, HY; Liu, X; Moriarty, RM; Naithani, R; O'Regan, RM; Peng, XH; Wood, WC; Yang, L | 1 |
| Bogush, A; Chan, T; Ehrlich, ME; Gieringer, T; Mao, Z; Pedrini, S; Pelta-Heller, J; Sluzas, E; Yang, Q | 1 |
| Chen, WH; Chen, Y; He, J; Wu, QL | 1 |
| Chen, Y; He, J; Liu, H; Wu, Q | 1 |
| Hong, SS; Hong, WK; Jin, Q; Kim, KW; Kim, WY; Lee, HY; Myers, JN; Oh, SH; Park, HJ; Suh, YG; Woo, JK; Yazici, YD | 1 |
| Deforce, D; Geeraerts, B; Offner, F; Philippé, J; Vanden Berghe, W; Vanhoecke, B | 1 |
| Chandrakanthan, V; Day, ML; Li, Y; O'Neill, C | 1 |
| Chen, WH; Chen, Y; Cui, GH; He, J; Liu, HL; Wu, QL | 2 |
| Hong, WK; Jeong, JW; Jin, Q; Kang, HJ; Kim, KW; Lee, HY; Oh, SH; Woo, JK | 1 |
| Kang, HJ; Kim, JH; Kim, KW; Lee, HY; Park, KH; Yu, YS | 1 |
| Chen, L; Fu, A; Li, Y; Luo, H; Luo, Y; Peng, A; Shi, J; Song, H; Tang, M; Wei, Y; Xu, Y; Ye, H | 1 |
| Behrens, C; Bekele, BN; Feng, L; Hong, WK; Jin, Q; Lee, HY; Wistuba, II | 1 |
| Chen, Y; Cui, G; Li, R; Shu, W; Wu, Q | 1 |
| Kim, JH; Kim, KW; Lee, HY; Shin, JY; Yu, YS | 1 |
| Brink, CB; Oliver, DW; Pretorius, A; van Niekerk, BP; Venter, DP | 1 |
| Choi, JS; Hong, SS; Kim, KW; Lee, DH; Lee, HS; Lee, JH | 1 |
| Li, H; Wang, X; Wu, Z; Yi, T | 1 |
| Chang, YC; Chen, IS; Chen, JJ; Cheng, LY; Cho, JY; Chou, TH; Hwang, TL; Lee, TH; Wang, TC | 1 |
| Chang, DJ; Geo, SY; Han, SH; Hennessy, B; Hong, WK; Kang, HJ; Kim, KW; Kim, WY; Kim, YS; Lee, HY; Mills, G; Park, HJ; Seo, SY; Suh, YG; Yoo, J | 1 |
| Choi, DS; Gilbert, BE; Hong, WK; Lee, HY; Tran, HT; Woo, JK | 1 |
| Chen, Y; Chen, Z; Ke, WJ; Li, R; Shu, WX | 1 |
| Chen, Y; Chen, YQ; Cui, GH; Li, R; Wu, Q | 1 |
| Ishida, Y; Ito, S; Murai, K; Oyake, T | 1 |
| Mehta, RG; Murillo, G; Peng, X; Torres, KE | 1 |
| Brown, PH; Rodenberg, JM | 1 |
| Dennis, PA; Memmott, RM | 1 |
| Chen, L; Chen, X; Duan, X; Fu, A; Hu, J; Wang, Y; Wei, Y; Xiao, W; Ye, H; Ye, X | 1 |
| Barluenga, S; Beebe, K; Garcia, J; Neckers, L; Winssinger, N | 1 |
| Hong, SS; Jung, KH; Lee, H; Lee, JH | 1 |
| Arulampalam, V; Björklund, AC; Grandér, D; Hjortsberg, L; Kolosenko, I; Tamm, KP | 1 |
| Chen, R; Cui, Y; Gan, C; Ji, W; Lin, X; Zhou, Q | 1 |
| Menon, M; Thamilselvan, S; Thamilselvan, V | 1 |
| Chu, ZH; Huang, RF; Jiang, JW; Liang, XH; Zhan, Qz; Zhou, XL | 1 |
| Arms, L; Vizzard, MA | 1 |
| Boggs, N; Boyd, J; Le, H; Patrone, JB; Saksena, A; Theodore, M; Williams, HN | 1 |
| Barluenga, S; Garcia, J; Gorska, K; Sasse, F; Winssinger, N | 1 |
| Asel, C; Buss, SJ; Hagenmueller, M; Hardt, SE; Katus, HA; Malekar, P; Riffel, JH; Weiss, C; Zhang, M | 1 |
| Chung, JG; Hsia, TC; Ji, BC; Ko, YC; Lai, KC; Lai, TY; Lin, JJ; Yang, JS; Yang, ST; Yu, CC | 1 |
| Cha, MY; Jung, HC; Kang, HW; Kim, JM; Kim, JS; Song, IS | 1 |
| Ellinghaus, P; Holfeld, J; Karnowski, N; Ockelmann, P; Paulus, P; Scheller, B; Tacke, S; Urbschat, A; Zacharowski, K | 1 |
| Angenot, L; Frédérich, M; Kalume, MK; Losson, B; Saegerman, C; Tits, M; Wauters, JN | 1 |
| Chen, L; Du, Y; Duan, X; Gao, X; Gou, M; Huang, M; Li, L; Liu, W; Men, K; Qian, Z; Wang, B; Wang, P; Wei, X; Wei, Y | 1 |
| Boreddy, SR; Srivastava, SK | 1 |
| Boyd, J; Vrana, JA; Williams, HN | 1 |
| An, H; Cha, JH; Chang, DJ; Han, YT; Jung, J; Kim, HH; Kim, JH; Kim, KS; Kim, KW; Kim, NJ; Kim, SG; Lee, G; Lee, HY; Lee, JM; Lee, JS; Lee, S; Lee, SC; Park, JH; Park, JW; Suh, YG; Yun, H | 1 |
| Boo, HJ; Kim, JH; Kim, KW; Lee, HJ; Lee, HY; Lee, SH; Min, HY; Suh, YA; Suh, YG; Sung, MA; Yun, HJ | 1 |
| Bi, ZG; Cheng, L; Gu, B; Ji, C; Lu, CC; Wang, R; Yang, YL | 1 |
| Alimirah, F; Gupta, A; Kalra, A; Katta, H; Mehta, RG; Mehta, RR; Murillo, G; Muzzio, M; Patel, R; Peng, X; Unni, A | 1 |
| Bai, ML; Li, HJ; Zhang, LX | 1 |
| Alimirah, F; Katta, H; Mehta, R; Mehta, RG; Murillo, G; Muzzio, M; Patel, R; Peng, X | 1 |
| Chen, HB; Chen, S; Hu, XH; Jiang, KH; Lan, Y; Song, XF; Wang, YL; Yuan, HG; Yuan, W; Zhao, CX; Zhu, SL | 1 |
| Liu, HL; Xiong, JR | 1 |
| Boggs, N; Boyd, J; Currie, HN; Vrana, JA | 1 |
| Boggs, N; Boyd, JW; Currie, HN; Han, AA; Scardoni, G; Vrana, JA | 1 |
| Bilecová-Rabajdová, M; Birková, A; Durovcová, E; Gregová, K; Mareková, M; Urban, P | 1 |
| Chen, K; Chen, L; Li, S; Li, Y; Liu, Z; Long, C; Peng, A; Tang, H; Tang, M; Wu, W; Xiang, M; Xie, C; Yang, J; Ye, H | 1 |
| Chen, Y; Cui, G; He, J; Wang, Y; Wen, L; Yi, S; Zhao, F; Zhao, J; Zhao, Z | 1 |
| Au, MK; Chang, JB; Chung, JG; Hsu, SC; Lin, JH; Lin, JP; Liu, CM; Liu, JY; Lu, HF; Shang, HS; Wu, PP | 1 |
| Chen, Y; Cui, G; Fang, J; He, J; Hu, JY; Wang, YP; Wen, L; Yi, S; Zhang, BP; Zhang, C; Zhao, F; Zhao, Z | 1 |
| Chen, PS; Hong, CY; Hsiao, M; Hsiao, YW; Lai, TC; Lee, CH; Lee, JJ; Lin, SK; Liu, WT; Liu, YP; Lu, PJ; Ping Kuo, MY | 1 |
| An, H; Chang, DJ; Jang, J; Kim, K; Lee, J; Lee, S; Sim, J; Suh, YG | 1 |
| Choi, H; Hong, HS; Kim, H; Kim, HS; Kim, KC; Kim, KW; Lee, HY; Lee, J; Lee, MY; Lee, SC; Min, HY; Park, HJ; Park, SJ; Seo, JH; Seong, MA; Suh, YG | 1 |
| Baba, Y; Fujii, M; Kato, Y; Maeda, T; Suzuki, A; Yuzawa, S | 1 |
| Lee, D; Lee, HE; Lee, HY; Lee, SH; Lee, YM; Nguyen, MP | 1 |
| Choi, H; Hong, M; Kim, HS; Kim, J; Kim, JH; Kim, JY; Kim, KW; Kim, YM; Lee, HY; Lee, J; Lee, SC; Oh, DC; Park, HJ; Park, SJ; Seo, JH; Suh, YG | 1 |
| Cartner, LK; Fuller, RW; Gustafson, KR; Henrich, CJ; McMahon, JB; Reilly, KM; Rizzo, AE; Wilson, JA | 1 |
| Kim, I; Nayak, M | 1 |
| Bisen, PS; Bundela, S; Sharma, A | 1 |
| Chiang, JH; Chung, JG; Hsia, TC; Hsu, YC; Lai, KC; Lien, JC; Wu, RS; Yu, CS; Yu, FS | 1 |
| Ali, A; Ansari, SA; Asif, M; Gillani, Z; Hafeez, S; Haque, A; Iqbal, Z; Jamal, MS; Mir, MA; Naseer, MI; Pushparaj, PN; Qazi, MH; Rasool, M; Saleem, S; Shaheen, S; Urooj, M | 1 |
| Jiao, Y; Zhang, Z; Zhao, H | 1 |
| Castejon, R; Losada-Fernandez, I; Martinez, A; Morado, M; Perez-Aciego, P; Perez-Chacon, G; Rebolleda, N; Rosado, S; Vallejo-Cremades, MT; Vargas-Nuñez, JA | 1 |
| Alves, C; Arruda, A; Arruda, M; da Costa, D; Da Silva, M; E Silva, C; Frommenwiler, D; Guilhon, G; Pinheiro, A | 1 |
| Akamatsu, S; Enomoto, Y; Iida, H; Iwama, T; Kojima, K; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Ogura, S; Otsuka, T; Tokuda, H; Tsujimoto, M | 1 |
| Cai, S; Cichewicz, RH; Mooberry, SL; Robles, AJ | 1 |
| Bao, Z; Lu, G; Yan, B; Yao, Y; Zhao, D; Zhou, J | 1 |
| Vargas Núñez, JA | 1 |
| Ann, J; Choi, H; Hong, M; Kim, HS; Kim, J; Kim, JY; Kim, KW; Kim, YM; Lee, HY; Lee, J; Lee, SC; Nguyen, CT; Park, HJ; Park, SJ; Seo, JH; Suh, YG; Yoon, S | 1 |
| Boyd, J; Han, A | 1 |
| Chang, NC; Lee, TM; Lin, SZ | 1 |
| Ciardiello, JJ; Freudenreich, JJ; Russell, DA; Sore, HF; Spring, DR | 1 |
| Baba, Y; Fujii, M; Kato, Y; Maeda, T; Suzuki, A; Takada, S | 1 |
| Guo, XJ; He, RZ; Li, X; Peng, F; Qin, RY; Shen, M; Shi, CJ; Shi, XH; Wang, M; Wang, X; Xu, XD; Zhang, M; Zhao, Y | 1 |
| Dong, X; Gao, F; Li, W; Ma, X; Wang, R; Wang, W | 1 |
| Chen, Y; Fang, J; He, J; Hu, J; Ruan, J; Wen, L; Yi, S; Zhang, X; Zhao, Z | 1 |
| Chen, Y; Cui, D; Han, W; Liu, X; Zhao, D | 1 |
| Bao, Z; Lu, G; Tong, Z; Tu, L; Yan, B; Yang, G; Yao, Y; Zhang, P; Zhou, J | 1 |
| Andrews, KT; Ansell, BRE; Auwerx, J; Baell, J; Chang, BCH; Cornaglia, M; Crawford, S; Davis, RA; Fisher, GM; Gasser, RB; Gijs, MAM; Hofmann, A; Jabbar, A; Korhonen, PK; McGee, SL; Mouchiroud, L; Nowell, C; Preston, S; Sternberg, PW; Young, ND | 1 |
| Chang, BCH; Davis, RA; Dilrukshi Herath, HMP; Gasser, RB; Hofmann, A; Jabbar, A; Koehler, AV; Preston, S | 1 |
| Bi, Y; Chen, Y; Ma, F; Wang, A; Wang, W; Wei, X | 1 |
| Li, W; Liang, Q; Liu, H; Liu, W; Yu, X; Zhou, L | 1 |
| Baba, Y; Kato, Y | 1 |
| Chen, JC; Chung, JG; Fan, MJ; Hsia, TC; Hsiao, YT; Huang, AC; Lien, JC; Lin, JJ; Wu, RS | 1 |
| Li, W; Lin, A; Wang, G; Xu, F; Xu, J; Xu, S; Yao, H | 1 |
| Guo, S; Kang, W; Wang, P; Zheng, X | 1 |
| Ambrico, A; Chandel, NS; Di Francesco, ME; El-Amine, N; Herzka, T; Lee, MF; Marszalek, JR; Mathew, G; Naguib, A; Pappin, DJ; Reczek, CR; Salas, IC; Trotman, LC; Watrud, K; Zheng, W | 1 |
| Li, W; Liu, H; Liu, L; Ma, X; Wang, J; Xia, Z; Xie, L; Yang, Y; Yu, X; Zhou, H; Zhou, X | 1 |
| Chen, J; Hu, X; Liu, W; Peng, L; Yang, F; Yi, H | 1 |
| Han, W; Li, X; Liu, Q; Lu, X; Qian, Y; Yang, W; Zhang, T; Zhao, K | 1 |
| Li, W; Liu, H; Liu, L; Ma, X; Wang, J; Xia, Z; Xie, L; Yang, Y; Yu, X; Zhou, H | 1 |
| Lei, C; Sun, X | 1 |
| Murphy, EA; Nukui, M; O'Connor, CM | 1 |
| Gribaudo, G; Loregian, A; Luganini, A; Mercorelli, B; Palù, G | 1 |
| Lokhande, KB; Nagar, S; Swamy, KV | 1 |
| Feng, B; Mu, J; Qi, W; Tang, JY; Wei, Y; Wu, Q; Yang, LL; Zeng, W; Zhang, Q | 1 |
| Fujita, S; Inui, T; Kobayashi, M; Murayama, S; Ogiso, B; Takei, H; Yamamoto, K | 1 |
| Li, W; Ma, C; Wang, G; Xie, S; Xu, F; Xu, J; Xu, S; Yao, H; Zhu, Z | 1 |
| Ann, J; Chen, J; Cho, TM; Choi, H; Chul Kim, K; Hoang, VH; Hong, M; Kim, HS; Kim, JY; Kim, KW; Lee, J; Lee, S; Nguyen, CT; Park, HJ; Seo, JH; Sub Byun, W; Suh, YG; Yong Kim, J | 1 |
| Bhave, AS; Goh, BC; Kumar, AP; Lam, WS; Lee, SC; Lobie, PE; Marican, AABH; Sethi, G; Syn, NL; Varughese, RS; Viganeshwari, SH; Wang, J; Wang, L; Wong, AL | 1 |
| Carpenter, EL; Cassidy, PB; Chagani, S; Ganguli-Indra, G; Indra, AK; Laws, M; Nelson, D | 1 |
| Ates, H; Cengiz, H; Kocdor, H; Kocdor, MA | 1 |
| Abdullah, AS; Chen, H; Chen, J; Ho, W; Huang, J; Jiang, J; Kong, L; Liang, B; Liang, H; Liao, W; Liao, Y; Liu, H; Liu, X; Ning, C; Tian, L; Yang, Q; Ye, L; Zang, N; Zhou, B | 1 |
| Gao, F; Li, M; Li, W; Liu, H; Liu, W; Yu, X; Zhou, L | 1 |
| Hurem, S; Kyewalyanga, MS; Lyche, JL; Mmochi, AJ; Msuya, FE; Said, AH; Sandvik, M; Solhaug, A | 1 |
| Dong, Y; Ma, X; Xu, J; Xu, S; Zhou, H | 1 |
| Ann, J; Byun, WS; Kim, JY; Kim, YJ; Lee, J; Lee, S; Nam, G; Nguyen, CT; Park, HJ; Park, S; Sahu, R; Seo, JH | 1 |
| Aggarwal, D; Aggarwal, V; Bishayee, A; Kaur, G; Kumar, M; Loka, M; Masurkar, A; Mittal, S; Sak, K; Sethi, G; Tuli, HS; Varol, M | 1 |
| Redman, ZC; Tomco, PL; Wesolowski, J | 1 |
| Ann, J; Hong Seo, J; Kim, YJ; Lee, J; Min Park, J; Nam, G; Nguyen, CT; Park, HJ; Thanh La, M; Young Kim, J | 1 |
| Hioki, T; Iida, H; Kim, W; Kozawa, O; Kuroyanagi, G; Matsushima-Nishiwaki, R; Tachi, J; Tokuda, H | 1 |
| Ghosh, P; Lokhande, KB; Nagar, S; Venkateswara Swamy, K | 1 |
| Lin, ZY; Wu, L; Yao, TZ; Yun, QZ; Zhang, TW | 1 |
| Chen, J; Mellich, TA; Pearson, BJ; Zhang, M; Zhang, P; Zhang, Z | 1 |
| Cui, D; Lu, G; Yao, Y; Zhang, X; Zhou, J | 1 |
Reviews
5 review(s) available for rotenone and deguelin
| Article | Year |
|---|---|
Naturally occurring substances and their role in chemo-protective effects.
Topics: Biological Products; Calcitriol; Estrogen Receptor Modulators; Humans; Neoplasms; Polyphenols; Protective Agents; Retinoids; Rotenone; Sulfur Compounds; Terpenes | 2013 |
Deguelin and Its Role in Chronic Diseases.
Topics: Animals; Antineoplastic Agents, Phytogenic; Antioxidants; Chronic Disease; Disease Models, Animal; Drug Discovery; Electron Transport Complex I; Enzyme Inhibitors; Humans; Molecular Structure; Parkinson Disease, Secondary; Phytotherapy; Plants, Medicinal; Risk Factors; Rotenone; Signal Transduction | 2016 |
Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential.
Topics: Animals; Antineoplastic Agents, Phytogenic; Drug Development; Humans; Neoplasms; Rotenone | 2019 |
Deguelin targets multiple oncogenic signaling pathways to combat human malignancies.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinogenesis; Cell Proliferation; Humans; Neoplasms; Rotenone; Signal Transduction | 2021 |
Pharmacological basis and new insights of deguelin concerning its anticancer effects.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Autophagy; Cell Cycle; Humans; Neoplasm Metastasis; Neoplasms; Nucleophosmin; Rotenone | 2021 |
Other Studies
158 other study(ies) available for rotenone and deguelin
| Article | Year |
|---|---|
Derrisin, a new rotenoid from Derris malaccensis plain and anti-Helicobacter pylori activity of its related constituents.
Topics: Anti-Bacterial Agents; Drugs, Chinese Herbal; Helicobacter pylori; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plant Roots; Plants, Medicinal | 2002 |
Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa.
Topics: Cell Differentiation; Cell Proliferation; Convolvulaceae; Enzyme Precursors; Fibrosarcoma; Flavonoids; Gelatinases; HL-60 Cells; Humans; Matrix Metalloproteinase 9; Metalloendopeptidases; Neoplasm Invasiveness; Plant Extracts; Rotenone; Tumor Cells, Cultured; U937 Cells | 2007 |
Highly variable insect control efficacy of Tephrosia vogelii chemotypes.
Topics: Africa; Animals; Coleoptera; Flavonoids; Insect Control; Insecticides; Plant Leaves; Rotenone; Tephrosia; Weevils | 2012 |
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship | 2012 |
Phenolic Metabolites of Dalea ornata Affect Both Survival and Motility of the Human Pathogenic Hookworm Ancylostoma ceylanicum.
Topics: Albendazole; Ancylostoma; Ancylostomatoidea; Ancylostomiasis; Animals; Anthelmintics; Cricetinae; Disease Models, Animal; Disease Resistance; Fabaceae; Humans; Mebendazole; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Phenols; Plant Components, Aerial; Rosaceae; Saxifragaceae; Spleen | 2016 |
Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa.
Topics: Animals; Anti-Bacterial Agents; Fabaceae; Fruit; Inhibitory Concentration 50; Isoflavones; Lymphoma; Mice; Molecular Structure; Phenols; Plant Extracts | 2017 |
Hydroxylated Rotenoids Selectively Inhibit the Proliferation of Prostate Cancer Cells.
Topics: Animals; Antineoplastic Agents; Blood-Brain Barrier; Cattle; Cell Division; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Electron Transport Complex I; Humans; Male; Mitochondrial Membranes; Molecular Structure; Prostatic Neoplasms; Rotenone; Uncoupling Agents | 2020 |
Epothilone B stabilizes microtubuli of macrophages like taxol without showing taxol-like endotoxin activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Adhesion; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Interferon-gamma; Macrophage Activation; Macrophages; Mice; Microtubules; Nitric Oxide; Paclitaxel; Rotenone; Thiazoles | 1997 |
Anomalous structure-activity relationships of 13-homo-13-oxarotenoids and 13-homo-13-oxadehyrorotenoids.
Topics: Aedes; Animals; Goldfish; Humans; Insecticides; Male; Mice; Molecular Conformation; NAD(P)H Dehydrogenase (Quinone); Rotenone; Structure-Activity Relationship | 1997 |
NADH: ubiquinone oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells.
Topics: Breast Neoplasms; Electron Transport Complex I; Enzyme Induction; Epithelial Cells; Estradiol; Female; Humans; Insulin-Like Growth Factor I; NADH, NADPH Oxidoreductases; Ornithine Decarboxylase; Quinazolines; RNA, Messenger; Rotenone; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uncoupling Agents | 1998 |
Cubé resin insecticide: identification and biological activity of 29 rotenoid constituents.
Topics: Animals; Cattle; Crystallography, X-Ray; Electron Transport; Electron Transport Complex I; Mitochondria, Heart; NADH, NADPH Oxidoreductases; Ornithine Decarboxylase Inhibitors; Plant Extracts; Plant Roots; Resins, Plant; Rotenone; Structure-Activity Relationship | 1999 |
Pharmacokinetics of deguelin, a cancer chemopreventive agent in rats.
Topics: Animals; Anticarcinogenic Agents; Area Under Curve; Chromatography, High Pressure Liquid; Female; Half-Life; Rats; Rats, Sprague-Dawley; Rotenone; Tissue Distribution | 2001 |
Deguelin inhibits the growth of colon cancer cells through the induction of apoptosis and cell cycle arrest.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Division; Colonic Neoplasms; Cyclin-Dependent Kinases; HT29 Cells; Humans; Microfilament Proteins; Muscle Proteins; Proliferating Cell Nuclear Antigen; Retinoblastoma Protein; Rotenone; Tumor Cells, Cultured; Up-Regulation | 2002 |
Deguelin suppresses the formation of carcinogen-induced aberrant crypt foci in the colon of CF-1 mice.
Topics: Animals; Anticarcinogenic Agents; Azoxymethane; beta-N-Acetylhexosaminidases; Colon; Colonic Neoplasms; Female; Intestinal Mucosa; Mice; Molecular Structure; Piroxicam; Precancerous Conditions; Rotenone | 2003 |
[Modification of the analytical method for rotenoids in plants].
Topics: Benzopyrans; Chromatography, High Pressure Liquid; Derris; Insecticides; Plant Leaves; Plant Roots; Rotenone; Tephrosia | 2002 |
AKT and the phosphatidylinositol 3-kinase/AKT pathway: important molecular targets for lung cancer prevention and treatment.
Topics: Antineoplastic Agents; Cell Cycle; Humans; Lung Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Tumor Cells, Cultured | 2003 |
Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells.
Topics: Antineoplastic Agents; Apoptosis; Bronchial Neoplasms; Cell Cycle; Cells, Cultured; Drug Screening Assays, Antitumor; Genetic Vectors; Humans; Immunoblotting; Lung Neoplasms; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Signal Transduction; Tumor Cells, Cultured | 2003 |
Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti.
Topics: Aedes; Animals; Chromones; Dose-Response Relationship, Drug; Insecticides; Larva; Millettia; Molecular Structure; Plant Extracts; Pyrans; Rotenone; Seeds | 2003 |
Concise synthesis of the chemopreventitive agent (+/-)-deguelin via a key 6-endo hydroarylation.
Topics: Bridged-Ring Compounds; Catalysis; Cyclization; Molecular Structure; Platinum Compounds; Rotenone | 2003 |
Rotenone and rotenoids in cubè resins, formulations, and residues on olives.
Topics: Derris; Insecticides; Olea; Photochemistry; Resins, Plant; Rotenone; Sunlight | 2004 |
Deguelin-induced inhibition of cyclooxygenase-2 expression in human bronchial epithelial cells.
Topics: Apoptosis; Blotting, Western; Bronchi; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Division; Cell Line, Tumor; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cyclooxygenase 2; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Immunoblotting; Isoenzymes; Lung Neoplasms; Male; Membrane Proteins; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rotenone; Time Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2004 |
Apoptosis induction by the natural product cancer chemopreventive agent deguelin is mediated through the inhibition of mitochondrial bioenergetics.
Topics: Apoptosis; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cardiolipins; Caspases; Cell Biology; Cell Cycle; Cell Line, Tumor; DNA Fragmentation; DNA, Mitochondrial; Energy Metabolism; Female; Flow Cytometry; Humans; Intracellular Membranes; Lipid Peroxidation; Microscopy, Electron, Transmission; Microscopy, Phase-Contrast; Mitochondria; Oxygen Consumption; Permeability; Rotenone; Uncoupling Agents | 2004 |
Cancer chemopreventive activity of rotenoids from Derris trifoliata.
Topics: Animals; Antigens, Viral; Antineoplastic Agents, Phytogenic; Benzopyrans; beta Carotene; Cell Line; Fabaceae; Female; Herpesvirus 4, Human; Humans; Mice; Mice, Inbred ICR; Papilloma; Phytotherapy; Plant Extracts; Plant Stems; Rotenone; Skin Neoplasms; Virus Activation | 2004 |
Molecular mechanisms of deguelin-induced apoptosis in transformed human bronchial epithelial cells.
Topics: Apoptosis; Cell Survival; Cell Transformation, Neoplastic; Epithelial Cells; Humans; Lung Neoplasms; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rotenone; Tumor Cells, Cultured | 2004 |
Rotenone, deguelin, their metabolites, and the rat model of Parkinson's disease.
Topics: Animals; Brain Chemistry; Cells, Cultured; Chromatography, High Pressure Liquid; Corpus Striatum; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Infusion Pumps, Implantable; Injections, Subcutaneous; Insecticides; Liver; Male; Parkinson Disease; Rats; Rats, Inbred Lew; Rotenone; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Substantia Nigra; Uncoupling Agents | 2004 |
Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo.
Topics: Animals; Aorta; Blood Pressure; Blotting, Western; Bone Marrow Cells; Cells, Cultured; Chromones; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Inflammation; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rotenone; Sepsis; Shock, Septic; Time Factors; Tissue Distribution | 2005 |
7a-O-methyldeguelol, a modified rotenoid with an open ring-C, from the roots of Derris trifoliata.
Topics: Animals; Culex; Derris; Insecticides; Larva; Models, Molecular; Molecular Structure; Plant Roots; Rotenone | 2005 |
Deguelin, A PI3K/AKT inhibitor, enhances chemosensitivity of leukaemia cells with an active PI3K/AKT pathway.
Topics: Acute Disease; Antigens, CD34; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cells, Cultured; Cytarabine; Drug Resistance, Neoplasm; Erythropoietin; Etoposide; HL-60 Cells; Humans; Leukemia; Leukemia, Myeloid; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Rotenone; Signal Transduction; Stem Cell Factor; Stem Cells | 2005 |
Regulating expressions of cyclin D1, pRb, and anti-cancer effects of deguelin on human Burkitt's lymphoma Daudi cells in vitro.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Burkitt Lymphoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; Humans; Leukocytes, Mononuclear; Retinoblastoma Protein; Rotenone | 2005 |
Effect of deguelin on UVB-induced skin carcinogenesis.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Chemoprevention; DNA Adducts; Down-Regulation; Female; Humans; Mice; Multienzyme Complexes; Protein Serine-Threonine Kinases; Rotenone; Signal Transduction; Skin Neoplasms; Tumor Cells, Cultured; Ultraviolet Rays | 2005 |
Deguelin regulates nuclear pore complex proteins Nup98 and Nup88 in U937 cells in vitro.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Fabaceae; Humans; Nuclear Pore Complex Proteins; Plants, Medicinal; Rotenone; U937 Cells | 2005 |
Fast and versatile multiresidue method for the analysis of botanical insecticides on fruits and vegetables by HPLC/DAD/MS.
Topics: Chromatography, High Pressure Liquid; Fruit; Insecticides; Limonins; Mass Spectrometry; Pyrethrins; Rotenone; Ryanodine; Vegetables | 2005 |
Deguelin as a chemopreventive agent in mouse lung tumorigenesis induced by tobacco smoke carcinogens.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution | 2005 |
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
Topics: Animals; Anticarcinogenic Agents; Antineoplastic Agents; Benzo(a)pyrene; Bronchial Neoplasms; Carcinogens; Cell Transformation, Neoplastic; Enzyme Activation; Immunoblotting; Immunohistochemistry; Lung Neoplasms; Mice; Mice, Transgenic; Nitrosamines; Proto-Oncogene Proteins c-akt; Respiratory Mucosa; Rotenone; Smoking; Tobacco Smoke Pollution | 2005 |
Efficacy of deguelin and silibinin on benzo(a)pyrene-induced lung tumorigenesis in A/J mice.
Topics: Adenoma; Administration, Oral; Animals; Benzo(a)pyrene; Disease Models, Animal; Lung Neoplasms; Mice; Mice, Inbred A; Rotenone; Silybin; Silybum marianum; Silymarin | 2005 |
Deguelin inhibits expression of IkappaBalpha protein in Raji and U937 cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Humans; I-kappa B Proteins; Lymphoma, B-Cell; NF-KappaB Inhibitor alpha; Rotenone; Signal Transduction; Transcription Factor RelA; Tumor Necrosis Factor-alpha; U937 Cells | 2006 |
The Akt inhibitor deguelin, is an angiopreventive agent also acting on the NF-kappaB pathway.
Topics: Angiogenesis Inhibitors; Base Sequence; Cells, Cultured; DNA Primers; Enzyme-Linked Immunosorbent Assay; Homeostasis; Humans; NF-kappa B; Polymerase Chain Reaction; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Rotenone; Sarcoma, Kaposi; Tumor Suppressor Protein p53; Up-Regulation | 2007 |
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cells, Cultured; Drug Interactions; Epithelial Cells; Gene Expression Regulation; Humans; I-kappa B Kinase; Lymphocytes; Neoplasm Invasiveness; NF-kappa B; Proto-Oncogene Proteins c-akt; Rotenone; Tumor Necrosis Factor-alpha | 2006 |
Down-regulation of inhibitor of apoptosis proteins by deguelin selectively induces apoptosis in breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Division; Cell Line, Tumor; Colony-Forming Units Assay; DNA Primers; Down-Regulation; Female; Genes, Reporter; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rotenone; Survivin; X-Linked Inhibitor of Apoptosis Protein | 2007 |
AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro.
Topics: Androstadienes; Animals; Brain-Derived Neurotrophic Factor; Cells, Cultured; Cyclin-Dependent Kinase 5; Dopamine and cAMP-Regulated Phosphoprotein 32; Huntington Disease; Mice; Nerve Tissue Proteins; Neurons; Phosphatidylinositol 3-Kinases; Protein Kinases; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Wortmannin | 2007 |
[Effect of deguelin on expression of nup98 in K562 cells].
Topics: Antineoplastic Agents, Phytogenic; Cell Proliferation; Dose-Response Relationship, Drug; Humans; K562 Cells; Nuclear Pore Complex Proteins; RNA, Messenger; Rotenone | 2007 |
Anti-cancer effects of deguelin on human leukemia K562 and K562/ADM cells In Vitro.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Humans; K562 Cells; Rotenone | 2007 |
Structural basis for depletion of heat shock protein 90 client proteins by deguelin.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Binding Sites; Binding, Competitive; Cell Growth Processes; Female; Fructose-Bisphosphate Aldolase; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Mice; Mice, Nude; Models, Molecular; Neoplasms; Reactive Oxygen Species; Rotenone; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2007 |
Deguelin inhibits expression of IkappaBalpha protein and induces apoptosis of B-CLL cells in vitro.
Topics: Apoptosis; Case-Control Studies; Caspases; Cell Proliferation; Female; Humans; I-kappa B Proteins; Insecticides; Interleukin-4; Leukemia, Lymphocytic, Chronic, B-Cell; Male; NF-KappaB Inhibitor alpha; Poly(ADP-ribose) Polymerases; Rotenone | 2007 |
Direct evidence for the action of phosphatidylinositol (3,4,5)-trisphosphate-mediated signal transduction in the 2-cell mouse embryo.
Topics: Animals; Blastocyst; Calcium; Chromones; Embryo, Mammalian; Mice; Mice, Mutant Strains; Morpholines; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phospholipase C gamma; Platelet Activating Factor; Proto-Oncogene Proteins c-akt; RNA, Messenger; Rotenone; Signal Transduction; Zygote | 2007 |
[Effect of deguelin on proliferation and apoptosis of lymphoma Daudi cells and its mechanism].
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Burkitt Lymphoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; Down-Regulation; Flow Cytometry; Humans; Leukocytes, Mononuclear; Retinoblastoma Protein; Rotenone | 2007 |
[Deguelin regulates cell cycle and nuclear pore complex protein Nup98 and Nup88 in U937 cells in vitro].
Topics: Cell Cycle; Cell Proliferation; Humans; Nuclear Pore Complex Proteins; Rotenone; U937 Cells | 2007 |
Identification of novel antiangiogenic anticancer activities of deguelin targeting hypoxia-inducible factor-1 alpha.
Topics: Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Aorta; Blotting, Western; Cell Hypoxia; Cell Movement; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Collagen; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Drug Combinations; Endothelium, Vascular; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Laminin; Leupeptins; Luciferases; Mice; Neoplasms; Neovascularization, Pathologic; Proteasome Endopeptidase Complex; Proteoglycans; Reverse Transcriptase Polymerase Chain Reaction; Rotenone; Tumor Cells, Cultured; Ubiquitin; Vascular Endothelial Growth Factor A; Zebrafish | 2008 |
Antiangiogenic effect of deguelin on choroidal neovascularization.
Topics: Animals; Cells, Cultured; Choroid; Choroidal Neovascularization; Female; Humans; Mice; Mice, Inbred C57BL; Rotenone | 2008 |
Preparative isolation and purification of three rotenoids and one isoflavone from the seeds of Millettia pachycarpa Benth by high-speed counter-current chromatography.
Topics: Chromatography, High Pressure Liquid; Chromones; Countercurrent Distribution; Isoflavones; Magnetic Resonance Spectroscopy; Millettia; Pyrans; Rotenone; Seeds; Spectrometry, Mass, Electrospray Ionization | 2008 |
Implication of AMP-activated protein kinase and Akt-regulated survivin in lung cancer chemopreventive activities of deguelin.
Topics: AMP-Activated Protein Kinases; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins; Lung Neoplasms; Microtubule-Associated Proteins; Multienzyme Complexes; Neoplasm Proteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Rotenone; Survivin; Transfection; Uncoupling Agents | 2007 |
Deguelin represses both the expression of nucleophosmin and some nucleoporins: Nup88 and Nup214 in Jurkat cells.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Humans; Jurkat Cells; Leukemia; Nuclear Pore Complex Proteins; Rotenone | 2008 |
Deguelin inhibits retinal neovascularization by down-regulation of HIF-1alpha in oxygen-induced retinopathy.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Down-Regulation; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Infant, Newborn; Mice; Mice, Inbred C57BL; Oxygen; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Rotenone | 2008 |
Studies on cellular resilience and adaptation following acute and repetitive exposure to ozone in cultured human epithelial (HeLa) cells.
Topics: Adaptation, Physiological; Apoptosis; Cell Membrane; Cell Survival; DNA; HeLa Cells; Humans; Mitochondria; NF-kappa B; Oxidants, Photochemical; Ozone; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rotenone; Trypan Blue | 2008 |
Deguelin inhibits human hepatocellular carcinoma by antiangiogenesis and apoptosis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chickens; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Rotenone; Vascular Endothelial Growth Factor A | 2008 |
Enhancement radiosensitization of breast cancer cells by deguelin.
Topics: Apoptosis; Breast Neoplasms; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Radiation-Sensitizing Agents; Rotenone; Survivin | 2008 |
Phthalides from Pittosporum illicioides var. illicioides with inhibitory activity on superoxide generation and elastase release by neutrophils.
Topics: Benzofurans; Cytochalasin B; Humans; Inhibitory Concentration 50; Molecular Structure; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Elastase; Plant Roots; Plants, Medicinal; Rosales; Rotenone; Superoxides; Taiwan | 2008 |
A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chemoprevention; Gene Expression; Humans; Lung Neoplasms; Rotenone; Signal Transduction | 2008 |
Liposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.
Topics: Administration, Intranasal; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chromatography, High Pressure Liquid; Genes, ras; Humans; Immunohistochemistry; Liposomes; Lung Neoplasms; Mice; Mice, Mutant Strains; Precancerous Conditions; Rotenone; Tissue Distribution | 2009 |
Involvement of SRC-3 in deguelin-induced apoptosis in Jurkat cells.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Down-Regulation; Histone Acetyltransferases; Humans; Jurkat Cells; NF-kappa B; Nuclear Receptor Coactivator 3; Rotenone; Trans-Activators | 2009 |
Deguelin blocks cells survival signal pathways and induces apoptosis of HL-60 cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; HL-60 Cells; Humans; Protein Kinases; Rotenone; Signal Transduction | 2009 |
Deguelin suppresses cell proliferation via the inhibition of survivin expression and STAT3 phosphorylation in HTLV-1-transformed T cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line; Cell Proliferation; Cell Transformation, Viral; Down-Regulation; HTLV-I Infections; Humans; Inhibitor of Apoptosis Proteins; Microtubule-Associated Proteins; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Rotenone; Signal Transduction; STAT3 Transcription Factor; Survivin; T-Lymphocytes | 2010 |
Deguelin inhibits growth of breast cancer cells by modulating the expression of key members of the Wnt signaling pathway.
Topics: Apoptosis; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Proliferation; Female; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotenone; Signal Transduction; Tumor Cells, Cultured; Wnt Proteins | 2009 |
A novel look into estrogen receptor-negative breast cancer prevention with the natural, multifunctional signal transduction inhibitor deguelin.
Topics: beta Catenin; Breast Neoplasms; Female; Humans; Neoplasms, Hormone-Dependent; Receptors, Estrogen; Rotenone; Signal Transduction; Wnt Proteins | 2009 |
The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.
Topics: Animals; Carcinogens; Humans; Indoles; Inositol; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Mice; Nicotiana; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Sirolimus; Smoking; TOR Serine-Threonine Kinases | 2010 |
Deguelin--an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model.
Topics: Animals; Carcinoma, Lewis Lung; Cell Growth Processes; Cell Movement; Down-Regulation; Endothelial Cells; Female; Humans; Lymphangiogenesis; Lymphatic Metastasis; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; RNA, Messenger; Rotenone; Vascular Endothelial Growth Factor D | 2010 |
Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action.
Topics: Animals; Biological Products; HSP90 Heat-Shock Proteins; Mice; Molecular Structure; Rotenone | 2010 |
Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Cell Separation; Flow Cytometry; Humans; In Situ Nick-End Labeling; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; Rotenone; Stomach Neoplasms | 2010 |
Activation of STAT1 is required for interferon-alpha-mediated cell death.
Topics: Apoptosis; Cell Death; Cell Line, Tumor; HSP90 Heat-Shock Proteins; Humans; Interferon-alpha; Mutant Proteins; Oncogene Protein v-akt; Phosphorylation; Protein Kinase Inhibitors; Rotenone; Signal Transduction; Sirolimus; STAT1 Transcription Factor; Transfection | 2011 |
[Separation and preparation of two rotenoids from the roots of Derris by high-speed counter-current chromatography].
Topics: Chromatography, High Pressure Liquid; Countercurrent Distribution; Derris; Plant Roots; Rotenone | 2010 |
Anticancer efficacy of deguelin in human prostate cancer cells targeting glycogen synthase kinase-3 β/β-catenin pathway.
Topics: Antineoplastic Agents; beta Catenin; Cell Movement; Cell Proliferation; Cell Survival; Down-Regulation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Neoplasm Metastasis; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction | 2011 |
[Effects of deguelin on proliferation and apoptosis of MCF-7 breast cancer cells by phosphatidylinositol 3-kinase/Akt signaling pathway].
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction | 2011 |
Role for pAKT in rat urinary bladder with cyclophosphamide (CYP)-induced cystitis.
Topics: Animals; Blotting, Western; Cyclophosphamide; Cystitis; Drug Evaluation, Preclinical; Enzyme Activation; Female; Immunohistochemistry; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Rotenone; Urinary Bladder; Urothelium | 2011 |
Exploring the boundaries of additivity: mixtures of NADH: quinone oxidoreductase inhibitors.
Topics: Deoxyglucose; Enzyme Inhibitors; Hep G2 Cells; Humans; Models, Chemical; NAD(P)H Dehydrogenase (Quinone); Pyridazines; Rotenone | 2011 |
Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions.
Topics: Affinity Labels; Biotin; Cell Line, Tumor; HSP90 Heat-Shock Proteins; Humans; Rotenone; Tubulin; Tubulin Modulators | 2012 |
Chronic Akt blockade aggravates pathological hypertrophy and inhibits physiological hypertrophy.
Topics: Animals; Cardiomegaly; Cardiomegaly, Exercise-Induced; Enzyme Inhibitors; Male; Myocytes, Cardiac; Phosphorylation; Physical Conditioning, Animal; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Rotenone | 2012 |
Induction of DNA damage by deguelin is mediated through reducing DNA repair genes in human non-small cell lung cancer NCI-H460 cells.
Topics: Antineoplastic Agents; Ataxia Telangiectasia Mutated Proteins; BRCA1 Protein; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; Comet Assay; DNA Damage; DNA Modification Methylases; DNA Repair Enzymes; DNA Topoisomerases, Type I; DNA-Activated Protein Kinase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Electrophoresis, Agar Gel; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Nuclear Proteins; Protein Serine-Threonine Kinases; Real-Time Polymerase Chain Reaction; RNA, Messenger; Rotenone; Time Factors; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2012 |
Deguelin, an Akt inhibitor, down-regulates NF-κB signaling and induces apoptosis in colon cancer cells and inhibits tumor growth in mice.
Topics: Animals; Apoptosis; bcl-X Protein; Blotting, Western; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspase 3; Cell Line, Tumor; Colonic Neoplasms; Down-Regulation; In Situ Nick-End Labeling; Interleukin-8; Mice; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Real-Time Polymerase Chain Reaction; Rotenone; Signal Transduction; Statistics, Nonparametric | 2012 |
Deguelin attenuates reperfusion injury and improves outcome after orthotopic lung transplantation in the rat.
Topics: Animals; Intercellular Adhesion Molecule-1; Lung Transplantation; Male; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; Reperfusion Injury; Rotenone; Vascular Endothelial Growth Factor A | 2012 |
Rotenoid content and in vitro acaricidal activity of Tephrosia vogelii leaf extract on the tick Rhipicephalus appendiculatus.
Topics: Acaricides; Animals; Democratic Republic of the Congo; Dose-Response Relationship, Drug; Lethal Dose 50; Plant Extracts; Plant Leaves; Rhipicephalus; Rotenone; Tephrosia | 2012 |
Delivering instilled hydrophobic drug to the bladder by a cationic nanoparticle and thermo-sensitive hydrogel composite system.
Topics: Animals; Antineoplastic Agents; Cations; Cell Line, Tumor; Cell Proliferation; Drug Carriers; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrophobic and Hydrophilic Interactions; Mice; Mice, Inbred BALB C; Nanoparticles; Neovascularization, Pathologic; Particle Size; Rotenone; Solubility; Temperature; Urinary Bladder Neoplasms; Zebrafish | 2012 |
Deguelin suppresses pancreatic tumor growth and metastasis by inhibiting epithelial-to-mesenchymal transition in an orthotopic model.
Topics: Animals; Blotting, Western; Cadherins; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Luciferases; Mice; Mice, Nude; Models, Genetic; Neoplasm Metastasis; NF-kappa B; Pancreas; Pancreatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Rotenone; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta1; Tumor Burden; Xenograft Model Antitumor Assays | 2013 |
In vitro approach to predict post-translational phosphorylation response to mixtures.
Topics: Apoptosis; Cell Survival; Complex Mixtures; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hep G2 Cells; Humans; Membrane Proteins; Mitochondrial Membranes; Oxygen Consumption; Permeability; Phosphorylation; Potassium Cyanide; Predictive Value of Tests; Protein Processing, Post-Translational; Rotenone; Signal Transduction; Staurosporine; Toxicity Tests; Xenobiotics | 2013 |
Design, synthesis, and biological evaluation of novel deguelin-based heat shock protein 90 (HSP90) inhibitors targeting proliferation and angiogenesis.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzopyrans; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Screening Assays, Antitumor; Embryo, Nonmammalian; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Physiologic; Protein Binding; Rotenone; Stereoisomerism; Structure-Activity Relationship; Zebrafish | 2012 |
A novel antitumor activity of deguelin targeting the insulin-like growth factor (IGF) receptor pathway via up-regulation of IGF-binding protein-3 expression in breast cancer.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Inhibitor of Apoptosis Proteins; Insulin-Like Growth Factor Binding Protein 3; MCF-7 Cells; Mice; Mice, Nude; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Receptors, Somatomedin; RNA Interference; Rotenone; Signal Transduction; Survivin; Time Factors; Transfection; Tumor Burden; Up-Regulation; Xenograft Model Antitumor Assays | 2013 |
Deguelin induces both apoptosis and autophagy in cultured head and neck squamous cell carcinoma cells.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Autophagy; Carcinoma, Squamous Cell; Cell Line, Tumor; Ceramides; Cyclin-Dependent Kinase 4; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Inhibitor of Apoptosis Proteins; Mice; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Survivin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2013 |
Efficacy and mechanism of action of Deguelin in suppressing metastasis of 4T1 cells.
Topics: Animals; Cell Division; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; Lung Neoplasms; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Rotenone | 2013 |
[Effects of deguelin on the proliferation and apoptosis of human esophageal cancer cell Ec-109: an experimental research].
Topics: Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Humans; Proto-Oncogene Proteins c-bcl-2; Rotenone | 2013 |
Deguelin action involves c-Met and EGFR signaling pathways in triple negative breast cancer cells.
Topics: Animals; Apoptosis; Blotting, Western; Cell Proliferation; ErbB Receptors; Female; Fluorescent Antibody Technique; Humans; Immunoenzyme Techniques; Mice; Mice, Nude; NF-kappa B; Proto-Oncogene Proteins c-met; Proto-Oncogene Proteins c-myc; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Rotenone; Signal Transduction; STAT3 Transcription Factor; Triple Negative Breast Neoplasms; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2013 |
[Inhibitory effect of Akt inhibitor deguelin on the growth of PC-3 prostate cancer cells].
Topics: Cell Line, Tumor; Cell Proliferation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Male; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-mdm2; Rotenone | 2013 |
Regulatory effects of deguelin on proliferation and cell cycle of Raji cells.
Topics: Cell Cycle; Cell Line; Cell Proliferation; Humans; Rotenone | 2013 |
Amelioration of an undesired action of deguelin.
Topics: Apoptosis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hep G2 Cells; Humans; Imidazoles; Oxygen; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Plant Extracts; Pyridines; Rotenone; Structure-Activity Relationship | 2013 |
An approach to investigate intracellular protein network responses.
Topics: Cell Survival; Dose-Response Relationship, Drug; Hep G2 Cells; Humans; Imidazoles; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinases; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Rotenone; Structure-Activity Relationship; Toxicity Tests; Tumor Cells, Cultured | 2014 |
Millettia pachycarpa exhibits anti-inflammatory activity through the suppression of LPS-induced NO/iNOS expression.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cells, Cultured; Depression, Chemical; Disease Models, Animal; Edema; Flavones; Flavonoids; Lipopolysaccharides; Macrophages; Male; Mice, Inbred ICR; Millettia; Nitric Oxide; Nitric Oxide Synthase Type II; Phytotherapy; Rotenone; Seeds | 2014 |
Deguelin, a selective silencer of the NPM1 mutant, potentiates apoptosis and induces differentiation in AML cells carrying the NPM1 mutation.
Topics: Acute Disease; Apoptosis; Blotting, Western; Caspase 6; Caspase 8; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Leukemia, Myeloid; Mutant Proteins; Mutation; Nuclear Proteins; Nucleophosmin; RNA Interference; Rotenone; Tumor Suppressor Protein p53 | 2015 |
Deguelin inhibits the migration and invasion of U-2 OS human osteosarcoma cells via the inhibition of matrix metalloproteinase-2/-9 in vitro.
Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Osteosarcoma; Rotenone | 2014 |
Nontoxic-dose of deguelin induce NPMc+ AML cell differentiation by selectively targeting Mt NPM1/SIRT1 instead of HDAC1/3.
Topics: Apoptosis; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Granulocytes; Histone Deacetylase 1; Histone Deacetylases; Humans; Leukemia, Myeloid, Acute; Monocytes; Nuclear Proteins; Nucleophosmin; Proteasome Endopeptidase Complex; Receptors, Granulocyte Colony-Stimulating Factor; Rotenone; Sirtuin 1; Ubiquitin | 2014 |
Suppressive function of low-dose deguelin on the invasion of oral cancer cells by downregulating tumor necrosis factor alpha-induced nuclear factor-kappa B signaling.
Topics: Animals; Cell Line, Tumor; Female; Humans; Matrix Metalloproteinase 2; Mice; Mice, Inbred NOD; Mice, SCID; Mouth Neoplasms; Neoplasm Invasiveness; NF-kappa B; Rotenone; Signal Transduction; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2016 |
Total synthesis of (-)-deguelin via an iterative pyran-ring formation strategy.
Topics: Catalysis; Cyclization; Palladium; Pyrans; Rotenone; Stereoisomerism | 2015 |
Synthesis and Evaluation of a Novel Deguelin Derivative, L80, which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90.
Topics: Animals; Antineoplastic Agents; Benzopyrans; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Human Umbilical Vein Endothelial Cells; Humans; Lung Neoplasms; Mice; Mice, SCID; Quinolines; Rotenone; Signal Transduction; Xenograft Model Antitumor Assays | 2015 |
Deguelin induces apoptosis by targeting both EGFR-Akt and IGF1R-Akt pathways in head and neck squamous cell cancer cell lines.
Topics: Apoptosis; Cell Line, Tumor; Enzyme Activation; ErbB Receptors; Head and Neck Neoplasms; Humans; Neoplasms, Squamous Cell; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptors, Somatomedin; Rotenone; Signal Transduction | 2015 |
Deguelin inhibits vasculogenic function of endothelial progenitor cells in tumor progression and metastasis via suppression of focal adhesion.
Topics: Actins; Angiogenesis Inhibitors; Animals; Apoptosis; Carcinogenesis; Carcinoma, Lewis Lung; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemoprevention; Endothelial Progenitor Cells; Enzyme Activation; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; G1 Phase Cell Cycle Checkpoints; Green Fluorescent Proteins; Humans; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Protein Serine-Threonine Kinases; Rotenone; Xenograft Model Antitumor Assays | 2015 |
Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors.
Topics: Angiogenesis Inhibitors; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Molecular Structure; Retinal Vessels; Rotenone; Structure-Activity Relationship | 2015 |
Deguelins, Natural Product Modulators of NF1-Defective Astrocytoma Cell Growth Identified by High-Throughput Screening of Partially Purified Natural Product Extracts.
Topics: Animals; Astrocytes; Astrocytoma; Biological Products; Cell Cycle; Cell Proliferation; Fabaceae; Humans; Mice; Millettia; Molecular Structure; Rotenone | 2015 |
Alkyne Carbonyl Metathesis As a Means To Make 4-Acyl Chromenes: Syntheses of (±)-Deguelin and (±)-Munduserone.
Topics: Alkynes; Biological Products; Catalysis; Molecular Structure; Rotenone; Stereoisomerism | 2015 |
Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine.
Topics: Administration, Oral; Algorithms; Antineoplastic Agents; Berberine; Bortezomib; Colchicine; Databases, Pharmaceutical; Databases, Protein; Diterpenes; Humans; Hydroxamic Acids; Limonins; Lovastatin; Models, Statistical; Mouth Neoplasms; Predictive Value of Tests; Resveratrol; Rotenone; Stilbenes; Support Vector Machine; Vorinostat | 2015 |
Antitumor effects of deguelin on H460 human lung cancer cells in vitro and in vivo: Roles of apoptotic cell death and H460 tumor xenografts model.
Topics: Animals; Anticarcinogenic Agents; Apoptosis; Apoptosis Regulatory Proteins; Calcium; Caspase 3; Cell Line, Tumor; Cell Survival; Comet Assay; DNA Damage; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Rotenone; Xenograft Model Antitumor Assays | 2017 |
BAD, a Proapoptotic Protein, Escapes ERK/RSK Phosphorylation in Deguelin and siRNA-Treated HeLa Cells.
Topics: Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Binding Sites; Cytochromes c; HeLa Cells; Humans; Mitochondrial Membranes; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Docking Simulation; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2; Ribosomal Protein S6 Kinases; RNA Interference; Rotenone | 2016 |
Deguelin inhibits the migration and invasion of lung cancer A549 and H460 cells via regulating actin cytoskeleton rearrangement.
Topics: Actin Cytoskeleton; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hyaluronan Receptors; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pseudopodia; rac1 GTP-Binding Protein; rho-Associated Kinases; Rotenone; Signal Transduction | 2015 |
Synergistic Activity of Deguelin and Fludarabine in Cells from Chronic Lymphocytic Leukemia Patients and in the New Zealand Black Murine Model.
Topics: Age Factors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Cells, Cultured; Drug Synergism; Female; Humans; Immunoblotting; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Mice, Inbred NZB; Neoplasms, Experimental; NF-kappa B; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Tumor Cells, Cultured; Vidarabine | 2016 |
Using LC and Hierarchical Cluster Analysis as Tools to Distinguish Timbó Collections into Two Deguelia Species: A Contribution to Chemotaxonomy.
Topics: Chromatography, High Pressure Liquid; Cluster Analysis; Fabaceae; Insecticides; Plant Roots; Rotenone; Species Specificity | 2016 |
Thrombin Receptor-Activating Protein (TRAP)-Activated Akt Is Involved in the Release of Phosphorylated-HSP27 (HSPB1) from Platelets in DM Patients.
Topics: Aged; Area Under Curve; Blood Platelets; Diabetes Mellitus, Type 2; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Heat-Shock Proteins; HSP27 Heat-Shock Proteins; Humans; Male; Molecular Chaperones; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Aggregation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Rotenone | 2016 |
Selective activity of deguelin identifies therapeutic targets for androgen receptor-positive breast cancer.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Cell Survival; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Nitriles; Phenylthiohydantoin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Rotenone; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Triple Negative Breast Neoplasms; Xenograft Model Antitumor Assays | 2016 |
Deguelin Induces the Apoptosis of Lung Squamous Cell Carcinoma Cells through Regulating the Expression of Galectin-1.
Topics: Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Survival; Female; Galectin 1; Humans; Immunoblotting; Immunoprecipitation; Lung Neoplasms; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; Rotenone; Signal Transduction | 2016 |
[SYNERGISTIC ACTIVITY OF DEGUELIN AND FLUDARABINE IN PRIMARY CELLS FROM CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS (CLL) AND IN A CLL MURINE MODEL].
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Apoptosis; Disease Models, Animal; Drug Synergism; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mice; Middle Aged; Primary Cell Culture; Rotenone; Tumor Cells, Cultured; Vidarabine | 2014 |
Synthesis and biological evaluation of C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; HSP90 Heat-Shock Proteins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Molecular; Molecular Structure; Neovascularization, Pathologic; Rotenone; Structure-Activity Relationship | 2016 |
Effect of lithium on ventricular remodelling in infarcted rats via the Akt/mTOR signalling pathways.
Topics: Animals; Carrier Proteins; Dilatation; Fibrosis; GATA4 Transcription Factor; Heart Ventricles; Intracellular Signaling Peptides and Proteins; Lithium Compounds; Male; MAP Kinase Signaling System; Myocardial Contraction; Myocardial Infarction; NFATC Transcription Factors; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Rotenone; Sirolimus; Stimulation, Chemical; Time Factors; TOR Serine-Threonine Kinases; Ventricular Remodeling | 2017 |
Stereocontrolled semi-syntheses of deguelin and tephrosin.
Topics: Molecular Conformation; Rotenone; Stereoisomerism | 2017 |
Deguelin Potentiates Apoptotic Activity of an EGFR Tyrosine Kinase Inhibitor (AG1478) in PIK3CA-Mutated Head and Neck Squamous Cell Carcinoma.
Topics: Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Drug Synergism; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Head and Neck Neoplasms; Humans; Mutant Proteins; Mutation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Quinazolines; Rotenone; Squamous Cell Carcinoma of Head and Neck; Time Factors; Tyrphostins | 2017 |
Inhibition of Autophagy by Deguelin Sensitizes Pancreatic Cancer Cells to Doxorubicin.
Topics: Anticarcinogenic Agents; Apoptosis; Autophagy; Biomarkers; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Resistance, Neoplasm; Humans; Pancreatic Neoplasms; Rotenone | 2017 |
Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Down-Regulation; Glycolysis; Hexokinase; Humans; Lung Neoplasms; Mice; Rotenone | 2017 |
Deguelin induced differentiation of mutated NPM1 acute myeloid leukemia in vivo and in vitro.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Female; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; Nuclear Proteins; Nucleophosmin; Random Allocation; Rotenone; Xenograft Model Antitumor Assays | 2017 |
Deguelin inhibits epithelial-to-mesenchymal transition and metastasis of human non-small cell lung cancer cells by regulating NIMA-related kinase 2.
Topics: Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasm Metastasis; NIMA-Related Kinases; Rotenone | 2017 |
Deguelin Attenuates Allergic Airway Inflammation via Inhibition of NF-κb Pathway in Mice.
Topics: Animals; Asthma; Blotting, Western; Bronchoalveolar Lavage Fluid; Cell Line; Cell Survival; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunoglobulin E; Immunoglobulin G; Inflammation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Real-Time Polymerase Chain Reaction; Rotenone | 2017 |
Deguelin exerts potent nematocidal activity
Topics: Animals; Anthelmintics; Caenorhabditis elegans; Drug Resistance; Electron Transport; Energy Metabolism; Mitochondria; Mitochondrial Membranes; Rotenone | 2017 |
Screening of a small, well-curated natural product-based library identifies two rotenoids with potent nematocidal activity against Haemonchus contortus.
Topics: Animals; Antinematodal Agents; Biological Products; Drug Resistance; Haemonchiasis; Haemonchus; Larva; Rotenone | 2017 |
Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox).
Topics: A549 Cells; Apoptosis; Apoptosis Regulatory Proteins; Doxorubicin; Humans; Lung Neoplasms; Proto-Oncogene Proteins; Rotenone | 2018 |
Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma.
Topics: Animals; Apoptosis; Aurora Kinase B; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Mice; Rotenone; Xenograft Model Antitumor Assays | 2017 |
Deguelin, a Novel Anti-Tumorigenic Agent in Human Esophageal Squamous Cell Carcinoma.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Drug Therapy, Combination; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; G1 Phase Cell Cycle Checkpoints; Humans; Rotenone; Survival Rate | 2017 |
Deguelin Impairs Cell Adhesion, Migration and Invasion of Human Lung Cancer Cells through the NF-[Formula: see text]B Signaling Pathways.
Topics: Antineoplastic Agents, Phytogenic; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Dose-Response Relationship, Drug; Gene Expression; Humans; Lung Neoplasms; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Rotenone; Signal Transduction | 2018 |
Concise Total Synthesis of (±)-Deguelin and (±)-Tephrosin Using a Vinyl Iodide as a Key Building Block.
Topics: Biological Products; Hydroxylation; Rotenone; Stereoisomerism; Vinyl Compounds | 2018 |
Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rotenone; Signal Transduction; Stomach Neoplasms | 2018 |
Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cells, Cultured; Electron Transport Complex I; Enzyme Inhibitors; Fibroblasts; Glucose; Male; Mice; Prostatic Neoplasms; PTEN Phosphohydrolase; Rotenone; Tumor Suppressor Protein p53 | 2018 |
Deguelin attenuates non-small cell lung cancer cell metastasis through inhibiting the CtsZ/FAK signaling pathway.
Topics: A549 Cells; Carcinoma, Non-Small-Cell Lung; Cathepsin Z; Cell Line, Tumor; Cell Movement; Focal Adhesion Kinase 1; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Neoplasm Metastasis; Rotenone; Signal Transduction | 2018 |
The Natural Rotenoid Deguelin Ameliorates Diabetic Neuropathy by Decreasing Oxidative Stress and Plasma Glucose Levels in Rats via the Nrf2 Signalling Pathway.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hypoglycemic Agents; Male; NF-E2-Related Factor 2; Oxidative Stress; Rats, Sprague-Dawley; Rotenone; Signal Transduction | 2018 |
Deguelin inhibits RANKL-induced osteoclastogenesis in vitro and prevents inflammation-mediated bone loss in vivo.
Topics: Animals; Bone Diseases, Metabolic; Bone Marrow Cells; Bone Resorption; Cell Differentiation; Gene Expression Regulation; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophages; Male; Mice, Inbred C57BL; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Rotenone; Signal Transduction | 2019 |
Repression of Noxa by Bmi1 contributes to deguelin-induced apoptosis in non-small cell lung cancer cells.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Mitogen-Activated Protein Kinase 7; Proto-Oncogene Proteins c-bcl-2; Rotenone; Signal Transduction | 2018 |
Comparing lethal dose ratios using probit regression with arbitrary slopes.
Topics: Animals; Dose-Response Relationship, Drug; Insecta; Insecticides; Lethal Dose 50; Models, Statistical; Regression Analysis; Rotenone | 2018 |
The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts.
Topics: Cell Survival; Cytomegalovirus; Drug Resistance, Viral; Fibroblasts; Flavonoids; Gene Expression Regulation, Viral; Humans; Inhibitory Concentration 50; Rotenone; Virus Internalization; Virus Replication | 2018 |
Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on "The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts".
Topics: Cytomegalovirus; Drug Repositioning; Fibroblasts; Flavonoids; Gene Expression Regulation, Viral; Humans; Rotenone; Virus Replication | 2019 |
Molecular interaction studies of Deguelin and its derivatives with Cyclin D1 and Cyclin E in cancer cell signaling pathway: The computational approach.
Topics: Amino Acid Sequence; Computational Biology; Cyclin D1; Cyclin E; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Binding; Rotenone; Sequence Homology, Amino Acid; Signal Transduction | 2019 |
MG132 protects against renal dysfunction by regulating Akt-mediated inflammation in diabetic nephropathy.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Glomerular Mesangium; Glucose; Humans; Inflammation; Inflammation Mediators; Kidney; Leupeptins; Male; Mesangial Cells; Proteasome Inhibitors; Protective Agents; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Rotenone; Signal Transduction | 2019 |
Extracellular glucose-dependent IPSC enhancement by leptin in fast-spiking to pyramidal neuron connections via JAK2-PI3K pathway in the rat insular cortex.
Topics: AMP-Activated Protein Kinase Kinases; Animals; Cerebral Cortex; Chromones; Cortical Excitability; Electric Stimulation; Flavonoids; GABAergic Neurons; Glucose; Inhibitory Postsynaptic Potentials; Janus Kinase 2; Leptin; Mitogen-Activated Protein Kinase Kinases; Morpholines; Patch-Clamp Techniques; Phosphoinositide-3 Kinase Inhibitors; Primary Cell Culture; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyramidal Cells; Pyrazoles; Pyrimidines; Rats; Rats, Transgenic; Rotenone; Signal Transduction; Synaptic Transmission; Wortmannin | 2019 |
Design, synthesis, and biological evaluation of truncated deguelin derivatives as Hsp90 inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; HSP90 Heat-Shock Proteins; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Proteasome Endopeptidase Complex; Rotenone; Structure-Activity Relationship | 2019 |
Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HSP90 Heat-Shock Proteins; Humans; Models, Molecular; Molecular Structure; Rotenone; Structure-Activity Relationship | 2019 |
Mitochondrial complex I inhibitor deguelin induces metabolic reprogramming and sensitizes vemurafenib-resistant BRAF
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Electron Transport Complex I; Humans; MAP Kinase Signaling System; Mechanistic Target of Rapamycin Complex 1; Melanoma; Mitogen-Activated Protein Kinases; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Rotenone; Signal Transduction; Vemurafenib | 2019 |
Inhibition of Cancer Stem-Like Phenotype by Curcumin and Deguelin in CAL-62 Anaplastic Thyroid Cancer Cells.
Topics: AC133 Antigen; Apoptosis; Cell Cycle; Cell Line, Tumor; Curcumin; Docetaxel; Drug Therapy, Combination; Humans; Nanog Homeobox Protein; Neoplastic Stem Cells; Octamer Transcription Factors; Oxidative Stress; Phenotype; Rotenone; Superoxide Dismutase; Thy-1 Antigens; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms | 2019 |
Deguelin inhibits HCV replication through suppressing cellular autophagy via down regulation of Beclin1 expression in human hepatoma cells.
Topics: Antiviral Agents; Autophagy; Beclin-1; Carcinoma, Hepatocellular; Cell Line, Tumor; Down-Regulation; Hepacivirus; Hepatocytes; Humans; Liver Neoplasms; Plant Extracts; Rotenone; Virus Replication | 2020 |
Deguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization.
Topics: A549 Cells; Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; ErbB Receptors; F-Box-WD Repeat-Containing Protein 7; Female; Glycogen Synthase Kinase 3 beta; Humans; Lung Neoplasms; Mice, Nude; Mutation; Myeloid Cell Leukemia Sequence 1 Protein; Phosphorylation; Protein Kinase Inhibitors; Protein Stability; Rotenone; Signal Transduction; Tumor Burden; Ubiquitination; Xenograft Model Antitumor Assays | 2020 |
Isolation of the Tephrosia vogelii extract and rotenoids and their toxicity in the RTgill-W1 trout cell line and in zebrafish embryos.
Topics: Animals; Cell Line; Embryo, Nonmammalian; Insecticides; Plant Extracts; Rotenone; Tephrosia; Trout; Zebrafish | 2020 |
Development of a novel truncated deguelin derivative possessing nitric oxide donor as a potential anti-lung cancer agent.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Molecular Structure; Nitric Oxide Donors; Rotenone | 2020 |
Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90).
Topics: Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Down-Regulation; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; HSP90 Heat-Shock Proteins; Humans; Molecular Docking Simulation; Rotenone; Structure-Activity Relationship | 2020 |
Photochemical Pathways of Rotenone and Deguelin Degradation: Implications for Rotenoid Attenuation and Persistence in High-Latitude Lakes.
Topics: Alaska; Hydroxyl Radical; Lakes; Photochemical Processes; Photolysis; Rotenone; Water Pollutants, Chemical | 2021 |
Discovery of a simplified deguelin analog as an HSP90 C-terminal inhibitor for HER2-positive breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Female; HSP90 Heat-Shock Proteins; Humans; Molecular Docking Simulation; Molecular Structure; Rotenone; Structure-Activity Relationship | 2021 |
Olive polyphenols attenuate TNF-α-stimulated M-CSF and IL-6 synthesis in osteoblasts: Suppression of Akt and p44/p42 MAP kinase signaling pathways.
Topics: 3T3 Cells; Animals; Culture Media, Conditioned; Interleukin-6; Iridoid Glucosides; Macrophage Colony-Stimulating Factor; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Olea; Oncogene Protein v-akt; Phenylethyl Alcohol; Polyphenols; Rotenone; Signal Transduction; Tumor Necrosis Factor-alpha | 2021 |
Novel B, C-ring truncated deguelin derivatives reveals as potential inhibitors of cyclin D1 and cyclin E using molecular docking and molecular dynamic simulation.
Topics: Cyclin D1; Cyclin E; Molecular Docking Simulation; Molecular Dynamics Simulation; Rotenone | 2022 |
Variation in Rotenone and Deguelin Contents among Strains across Four
Topics: Animals; Aphids; Insecticides; Plant Extracts; Rotenone; Tephrosia | 2022 |
Deguelin Attenuates Non-Small-Cell Lung Cancer Cell Metastasis by Upregulating PTEN/KLF4/EMT Signaling Pathway.
Topics: A549 Cells; Animals; Carcinoma, Non-Small-Cell Lung; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Lung Neoplasms; Mice; Neoplasm Metastasis; PTEN Phosphohydrolase; Rotenone; Signal Transduction | 2022 |