rosmarinic-acid and ethyl-caffeate

The EtOAc extract of Rabdosia coetsa showed angiotensin-converting enzyme (ACE) inhibitory activity. Bioassay-guided isolation of this extract yielded ethyl caffeate (1), rosmarinic acid (2) and methyl rosmarinate (3), which inhibited ACE activity by 32.42%, 55.19% and 39.50% respectively, at the concentration of 10 microg/ml.

Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Caffeic Acids; Cinnamates; Depsides; Isodon; Lung; Peptidyl-Dipeptidase A; Plant Extracts; Rabbits; Rosmarinic Acid

To study the chemical constituents from the aerial parts of Polygomun aviculane.. The chemical constituents were isolated by silica gel column chromatography and preparative silica thin layer chromatography, and their structures were elucidated on the basis of physico-chemical evidences and spectroscopic analysis (IR, MS, 1H and 13C-NMR).. Seven phenolic compounds were identified as rosmarinic acid (1), gallic acid (2), gentisic acid 5-O-(6'-O-galloyl)-beta-D-glucopyranoside (3), caffeic acid (4), p-coumaric acid (5), ethyl caffeate (6) and acteoside (7), respectively.. Compounds 1, 3, 6 and 7 were isolated from this plant for the first time. These results provided theoretical evidences for the further bioactive investigation on this plant.

Topics: Caffeic Acids; Cinnamates; Depsides; Glucosides; Phenols; Plant Components, Aerial; Plants, Medicinal; Polygonum; Rosmarinic Acid