rosiglitazone has been researched along with warfarin in 44 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (11.36) | 18.2507 |
| 2000's | 17 (38.64) | 29.6817 |
| 2010's | 20 (45.45) | 24.3611 |
| 2020's | 2 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Goel, S; Jain, SC; Malhotra, S; Olsen, CE; Parmar, VS; Raj, HG; Singh, A; Wengel, J | 1 |
| Goel, S; Gupta, K; Jain, SC; Jha, HN; Olsen, CE; Parmar, VS; Raj, HG; Rohil, V; Singh, A; Tyagi, YK; Wengel, J | 1 |
| Garg, BS; Goel, S; Jain, SC; Olsen, CE; Parmar, VS; Raj, HG; Sharma, RK; Singh, A; Tyagi, YK; Wengel, J | 1 |
| Goel, S; Jain, SC; Jha, HN; Olsen, CE; Parmar, VS; Raj, HG; Singh, A; Tyagi, YK; Wengel, J | 1 |
| Das, SK; Goel, S; Jain, SC; Mittal, JP; Olsen, CE; Parmar, VS; Priyadarsini, KI; Raj, HG; Sharma, SK; Wengel, J | 1 |
| Goel, S; Jain, SC; Olsen, CE; Parmar, VS; Raj, HR; Sharma, SK; Tyagi, YK; Wengel, J | 1 |
| Ahmad, N; Goel, S; Jain, SC; Kohli, E; Olsen, CE; Parmar, VS; Raj, HG; Sharma, SK; Tyagi, YK; Wengel, J | 1 |
| Goel, S; Goswami, R; Jain, SC; Kohli, E; Olsen, CE; Parmar, VS; Raj, HG; Rastogi, RC; Wengel, J | 1 |
| Gupta, G; Jain, SC; Kohli, E; Kumari, R; Olsen, CE; Pal, G; Parmar, VS; Raj, HG; Tyagi, YK | 1 |
| Ahmad, N; Gaspari, M; Goel, S; Gupta, G; Jain, SC; Kohli, E; Kumari, R; Olsen, CE; Pal, G; Parmar, VS; Prasad, AK; Raj, HG; Tyagi, YK; van der Greef, J; Watterson, AC | 1 |
| Gaspari, M; Gupta, G; Khurana, P; Kohli, E; Kumari, R; Olsen, CE; Parmar, VS; Raj, HG; Sharma, SK; Tyagi, YK; van der Greef, J; Watterson, AC | 1 |
| Jain, SK; Kumar, A; Parmar, VS; Prasad, AK; Raj, HG; Rastogi, RC; Sharma, SK; Singh, BK; Tyagi, R; Watterson, AC | 1 |
| Dwarakanth, BS; Goel, S; Gulati, R; Gupta, G; Kumar, A; Kumari, R; Muralidhar, K; Parmar, VS; Patkar, SA; Raj, HG; Rastogi, RC; Saluja, D; Tyagi, YK; Vinocha, A | 1 |
| Bansal, S; Chopra, M; Kumar, A; Kumari, R; Parmar, VS; Ponnan, P; Prasad, AK; Raj, HG; Rastogi, RC; Saluja, D; Saso, L; Singh, P; Tyagi, TK; Weintraub, ST | 1 |
| Baghel, AS; Bansal, S; Bose, M; Gupta, G; Kumar, A; Kumari, R; Parmar, VS; Patkar, SA; Ponnan, P; Raj, HG; Saini, NK; Saluja, D; Tyagi, TK | 1 |
| Ghosh, B; Goel, A; Parmar, VS; Prasad, AK; Saini, N | 1 |
| Arora, S; Chatterjee, S; Kumar, A; Majumder, S; Parmar, VS; Prasad, AK; Raj, HG; Saluja, D; Saso, L; Tyagi, YK | 1 |
| Bansal, S; Batra, A; Collin, F; Guillonneau, F; Jore, D; Parmar, VS; Patkar, SA; Ponnan, P; Raj, HG; Rastogi, RC; Saxena, RK; Singh, P; Tyagi, TK | 1 |
| Kumar, V; Malhotra, SV; Marrosu, G; Parmar, VS; Petrucci, R; Prasad, AK; Saso, L | 1 |
| Arya, A; Arya, MB; Bhatt, AN; Dhawan, A; Dwarakanath, BS; Farooque, A; Khaitan, D; Khanna, S; Parmar, VS; Prasad, AK; Raj, HG; Saluja, D; Verma, A | 1 |
| Joshi, R; Kumar, A; Manral, S; Parmar, VS; Prasad, AK; Raj, HG; Rohil, V; Singh, U; Sinha, R; Sushama, A | 1 |
| Ahmad, S; Chhabra, R; Ghosh, B; Goel, A; Parmar, VS; Prasad, AK; Saini, N | 1 |
| Arora, S; Chatterji, S; Depass, AL; Dwarakanath, BS; Goel, S; Joshi, R; Kalra, N; Kumar, A; Manral, S; Parmar, VS; Prasad, AK; Raj, HG; Rawat, DS; Rohil, V; Saluja, D; Sharma, A; Sinha, R | 1 |
| Firuzi, O; Latina, V; Parmar, VS; Prasad, AK; Salemme, A; Saso, L; Togna, AR; Togna, GI | 1 |
| Arya, A; Arya, MB; Bhatt, AN; Dhawan, A; Dwarakanath, BS; Farooque, A; Kalra, N; Parmar, VS; Prasad, AK; Raj, HG; Venkateswaran, K; Verma, A | 1 |
| Arora, S; Bracke, ME; Chatterji, S; DePass, AL; Dwarakanath, BS; Goel, S; Joshi, R; Kohli, E; Kumar, A; Manral, S; Parmar, VS; Ponnan, P; Prasad, AK; Priya, N; Raj, HG; Rawat, DS; Rohil, V; Saluja, D; Saso, L; Singh, P | 1 |
| Arora, A; Arya, MB; Bhatt, AN; Dwarakanath, BS; Parmar, VS; Prasad, AK; Verma, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Amaudrut, J; Barth, M; Binet, J; Boubia, B; Broqua, P; Chatar, M; Dodey, P; Ferry, S; Gauthier, E; Guillier, F; Jacquier, E; Junien, JL; Lacombe, O; Legendre, C; Lepais, V; Llacer, J; Luccarini, JM; Masson, P; Montalbetti, C; Mounier, L; Peralba, P; Poupardin, O; Thourigny, A; Wettstein, G | 1 |
| Balusu, P; Buch, HA; Hoffmann, TK; Parker, DL | 1 |
| Feng, Y; Hörling, J; Hu, X; Leng, Y; Liu, X; Sydow-Bäckman, M; Yang, YS; Yu, JH; Zhao, XF; Zierath, JR | 1 |
| Qi, Z; Wang, H; Xie, M; Xue, J; Zhang, Y | 1 |
| Das, N; Kumar, P; Moorthy, NS; Shrivastava, SK; Shukla, S; Srivastava, RS; Trivedi, P | 1 |
| Newman, EM; Rowland, A | 1 |
3 review(s) available for rosiglitazone and warfarin
| Article | Year |
|---|---|
The Competence of 7,8-Diacetoxy-4-Methylcoumarin and Other Polyphenolic Acetates in Mitigating the Oxidative Stress and their Role in Angiogenesis.
Topics: Coumarins; Enzyme-Linked Immunosorbent Assay; Humans; Neovascularization, Pathologic; Oxidative Stress; Polyphenols; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; Thioredoxins; Vascular Endothelial Growth Factor A | 2015 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
A Physiologically Based Pharmacokinetic Model to Predict the Impact of Metabolic Changes Associated with Metabolic Associated Fatty Liver Disease on Drug Exposure.
Topics: Animals; Caffeine; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dextromethorphan; Metoprolol; Midazolam; Non-alcoholic Fatty Liver Disease; Omeprazole; Rosiglitazone; Warfarin | 2022 |
41 other study(ies) available for rosiglitazone and warfarin
| Article | Year |
|---|---|
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part I: Dioxygenated 4-methyl coumarins as superb antioxidant and radical scavenging agents.
Topics: Animals; Antioxidants; Coumarins; Free Radical Scavengers; In Vitro Techniques; Lipid Peroxidation; Microsomes, Liver; Rats; Structure-Activity Relationship; Vitamin E | 1998 |
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B1-DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin.
Topics: 7-Alkoxycoumarin O-Dealkylase; Aflatoxin B1; Animals; Antimutagenic Agents; Biotransformation; Bone Marrow Cells; Coumarins; Cytochrome P-450 CYP1A1; Dietary Supplements; DNA; Male; Micronucleus Tests; Microsomes, Liver; Mutagens; Rats; Time Factors | 1998 |
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 3: A novel mechanism for the inhibition of biological membrane lipid peroxidation by dioxygenated 4-methylcoumarins mediated by the formation of a stable ADP-Fe-inhibitor mixed
Topics: Adenosine Diphosphate; Animals; Antioxidants; Carbon Tetrachloride; Coumarins; Iron; Kinetics; Ligands; Lipid Peroxidation; Lung; Male; Microsomes, Liver; Paraquat; Rats; Rats, Wistar; Structure-Activity Relationship; Superoxides; Thiobarbituric Acid Reactive Substances | 1998 |
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 4: hyperbolic activation of rat liver microsomal NADPH-cytochrome C reductase by the novel acetylator 7,8-diacetoxy-4-methylcoumarin.
Topics: Acetylation; Animals; Coumarins; Dose-Response Relationship, Drug; Hydroxymercuribenzoates; Kinetics; Male; Microsomes, Liver; Models, Chemical; NADPH-Ferrihemoprotein Reductase; Rats; Rats, Wistar; Time Factors | 1999 |
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 5: Pulse radiolysis studies on the antioxidant action of 7,8-diacetoxy-4-methylcoumarin.
Topics: Antioxidants; Coumarins; Free Radical Scavengers; Oxidation-Reduction; Pulse Radiolysis; Pyrans; Superoxides | 1999 |
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 6: hydrolysis of 7,8-diacetoxy-4-methylcoumarin by a novel deacetylase in rat liver microsomes--a simple method for assay and characterisation.
Topics: Acetylesterase; Animals; Benzopyrans; Carboxylic Ester Hydrolases; Coumarins; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Male; Microsomes, Liver; Rats; Rats, Wistar; Substrate Specificity | 2000 |
Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 7: Assay and characterization of 7,8-diacetoxy-4-methylcoumarin:protein transacetylase from rat liver microsomes based on the irreversible inhibition of cytosolic glutathione S
Topics: Acetylation; Acetyltransferases; Animals; Benzopyrans; Chromatography, High Pressure Liquid; Coumarins; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glutathione Transferase; Kinetics; Male; Microsomes, Liver; Rats; Rats, Wistar; Substrate Specificity; Time Factors | 2000 |
Mechanism of biochemical action of substituted benzopyran-2-ones. Part 8: Acetoxycoumarin: protein transacetylase specificity for aromatic nuclear acetoxy groups in proximity to the oxygen heteroatom.
Topics: Aflatoxin B1; Animals; Benzopyrans; Coumarins; DNA; Enzyme Activation; Glutathione Transferase; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxygen; Rats; Rats, Wistar; Structure-Activity Relationship; Substrate Specificity; Umbelliferones | 2001 |
Microsomal acetoxy drug: protein transacetylase of placenta: part 1. Characterization of DAMC: GST transacetylase.
Topics: Acetyltransferases; Adult; Animals; Coumarins; Female; Glutathione; Glutathione Transferase; Humans; In Vitro Techniques; Kinetics; Male; Mice; Microsomes; NADPH-Ferrihemoprotein Reductase; Placenta; Pregnancy; Rats; Rats, Wistar; Substrate Specificity | 2002 |
Establishment of the enzymatic protein acetylation independent of acetyl CoA: recombinant glutathione S-transferase 3-3 is acetylated by a novel membrane-bound transacetylase using 7,8-diacetoxy-4-methyl coumarin as the acetyl donor.
Topics: Acetyl Coenzyme A; Acetylation; Acetylesterase; Coumarins; Glutathione Transferase; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
Acetoxy drug: protein transacetylase of buffalo liver-characterization and mass spectrometry of the acetylated protein product.
Topics: Acetylation; Acetyltransferases; Amino Acid Sequence; Animals; Buffaloes; Coumarins; Glutathione Transferase; Liver; Microsomes, Liver; Molecular Sequence Data; Peptides; Protein Structure, Tertiary; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Mechanism of biochemical action of substituted 4-methylcoumarins. Part 11: Comparison of the specificities of acetoxy derivatives of 4-methylcoumarin and 4-phenylcoumarin to acetoxycoumarins: protein transacetylase.
Topics: Acetylation; Acetyltransferases; Aflatoxin B1; Animals; Coumarins; Cytosol; DNA; Flavonoids; Glutathione Transferase; Microsomes, Liver; NADPH-Ferrihemoprotein Reductase; Oxygen; Phenols; Polyphenols; Rats; Structure-Activity Relationship; Substrate Specificity | 2005 |
Characterization of protein transacetylase from human placenta as a signaling molecule calreticulin using polyphenolic peracetates as the acetyl group donors.
Topics: Acetates; Acetyltransferases; Calcium; Calreticulin; Coumarins; Endoplasmic Reticulum; Flavonoids; Humans; Kinetics; Phenols; Placenta; Polyphenols; Protein Binding; Protein Conformation; Protein Kinase C; Protein Structure, Tertiary; Signal Transduction | 2007 |
Autoacetylation of purified calreticulin transacetylase utilizing acetoxycoumarin as the acetyl group donor.
Topics: Acetylation; Acetyltransferases; Adult; Amino Acid Sequence; Biocatalysis; Calcium; Coumarins; Female; Humans; Hydrogen Bonding; Lysine; Models, Molecular; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Peptides; Protein Structure, Secondary; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2009 |
Establishment of glutamine synthetase of Mycobacterium smegmatis as a protein acetyltransferase utilizing polyphenolic acetates as the acetyl group donors.
Topics: Acetates; Acetylation; Acetyltransferases; Catalysis; Coumarins; Flavonoids; Glutamate-Ammonia Ligase; Mycobacterium smegmatis; Phenols; Polyphenols; Structure-Activity Relationship | 2008 |
Apoptogenic effect of 7,8-diacetoxy-4-methylcoumarin and 7,8-diacetoxy-4-methylthiocoumarin in human lung adenocarcinoma cell line: role of NF-kappaB, Akt, ROS and MAP kinase pathway.
Topics: Adenocarcinoma; Apoptosis; Caspases; Cell Proliferation; Coumarins; Cytochromes c; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Lung Neoplasms; Mitochondria; Mitogen-Activated Protein Kinases; NF-kappa B; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Signal Transduction; Tumor Cells, Cultured | 2009 |
The role of calreticulin transacetylase in the activation of human platelet nitrite reductase by polyphenolic acetates.
Topics: Acetyltransferases; Adenosine Diphosphate; Antioxidants; Blood Platelets; Calreticulin; Coumarins; Cyclic GMP; Electrodes; Enzyme Activation; Flavonoids; Flow Cytometry; Humans; NADPH-Ferrihemoprotein Reductase; Nitric Oxide; Nitric Oxide Synthase; Nitrite Reductases; Phenols; Platelet Aggregation; Polyphenols | 2009 |
Moonlighting protein in Starkeyomyces koorchalomoides: characterization of dihydrolipoamide dehydrogenase as a protein acetyltransferase utilizing acetoxycoumarin as the acetyl group donor.
Topics: Acetylation; Acetyltransferases; Coumarins; Dihydrolipoamide Dehydrogenase; Fungi; Glutathione Transferase; Streptococcus pneumoniae | 2009 |
A spectroelectrochemical and chemical study on oxidation of 7,8-dihydroxy-4-methylcoumarin (DHMC) and some related compounds in aprotic medium.
Topics: Acetonitriles; Benzoquinones; Coumarins; Electrochemistry; Molecular Structure; Oxidation-Reduction; Spectrophotometry, Ultraviolet | 2010 |
7, 8-diacetoxy-4-methylcoumarin induced cell death in human tumor cells is influenced by calreticulin.
Topics: Acetylation; Calreticulin; Cell Death; Cell Line, Tumor; Cell Proliferation; Coumarins; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; NF-kappa B; Reactive Oxygen Species; RNA, Small Interfering | 2011 |
Calreticulin Transacetylase mediated activation of human platelet nitric oxide synthase by acetyl group donor compounds.
Topics: Acetates; Acetylation; Acetyltransferases; Adenosine Diphosphate; Arginine; Blood Platelets; Cells, Cultured; Coumarins; Cyclic GMP; Cytochrome Reductases; Enzyme Inhibitors; Fluoresceins; Humans; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Platelet Aggregation; Polyphenols; Structure-Activity Relationship | 2012 |
DAMTC regulates cytoskeletal reorganization and cell motility in human lung adenocarcinoma cell line: an integrated proteomics and transcriptomics approach.
Topics: Actins; Adenocarcinoma; Adenocarcinoma of Lung; Apoptosis; Cell Line, Tumor; Cell Movement; Coumarins; Cytoskeleton; Humans; Intracellular Signaling Peptides and Proteins; Lung Neoplasms; Oncogene Proteins; Protein Deglycase DJ-1; Proteomics; rho GTP-Binding Proteins; rho Guanine Nucleotide Dissociation Inhibitor alpha; Signal Transduction; Transcriptome | 2012 |
Calreticulin transacetylase mediated upregulation of thioredoxin by 7,8-diacetoxy-4-methylcoumarin enhances the antioxidant potential and the expression of vascular endothelial growth factor in peripheral blood mononuclear cells.
Topics: Acetylation; Acetyltransferases; Antioxidants; Carrier Proteins; Coumarins; Humans; Leukocytes, Mononuclear; Reactive Oxygen Species; Thioredoxin-Disulfide Reductase; Thioredoxins; Up-Regulation; Vascular Endothelial Growth Factor A | 2013 |
4-Methylcoumarin derivatives with anti-inflammatory effects in activated microglial cells.
Topics: Animals; Anti-Inflammatory Agents; Coumarins; Cyclooxygenase 2; Dinoprostone; Inflammation; Inflammation Mediators; Microglia; Nitric Oxide; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Rats; Thromboxane B2; Tumor Necrosis Factor-alpha | 2014 |
Cytotoxic and radio-sensitizing effects of polyphenolic acetates in a human glioma cell line (BMG-1).
Topics: Acetates; Acetylation; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Coumarins; DNA Damage; DNA Repair; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Polyphenols; Radiation-Sensitizing Agents; Umbelliferones | 2014 |
Radiosensitization of calreticulin-overexpressing human glioma cell line by the polyphenolic acetate 7, 8-diacetoxy-4-methylcoumarin.
Topics: Acetates; Calreticulin; Cell Line; Coumarins; Glioma; Humans; Polyphenols; Radiation Tolerance; Radiation-Sensitizing Agents | 2022 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate.
Topics: Animals; Benzothiazoles; Carbon Tetrachloride Poisoning; Cell Line; Drug Discovery; Fibrosis; Hepatocytes; High-Throughput Screening Assays; Humans; Hypoglycemic Agents; Indoles; Mice; Mice, Inbred C57BL; Models, Molecular; Molecular Structure; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptors; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides | 2018 |
Suspected suppression of the INR by thiazolidinediones: interaction between warfarin and TZDs.
Topics: Aged; Aged, 80 and over; Anticoagulants; Drug Synergism; Female; Humans; Hypoglycemic Agents; International Normalized Ratio; Male; Pioglitazone; Rosiglitazone; Thiazolidinediones; Warfarin | 2006 |
Effect of a novel non-thiazolidinedione peroxisome proliferator-activated receptor alpha/gamma agonist on glucose uptake.
Topics: 3T3 Cells; Adenocarcinoma; Animals; Biological Transport; Cell Line, Tumor; Colonic Neoplasms; Coumarins; Genes, Reporter; Glucose; Humans; Mice; Muscle, Skeletal; Oxazoles; PPAR alpha; PPAR gamma; Rosiglitazone; Thiazolidinediones | 2007 |
Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats.
Topics: Adiponectin; Animals; Blood Glucose; Cnidium; Coumarins; Dietary Fats; Dietary Sucrose; Fatty Liver; Fenofibrate; Hypoglycemic Agents; Hypolipidemic Agents; Inflammation; Insulin; Insulin Resistance; Lipids; Liver; Male; Peroxisome Proliferator-Activated Receptors; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones | 2011 |
Synthesis, characterization, biological evaluation and docking of coumarin coupled thiazolidinedione derivatives and its bioisosteres as PPARγ agonists.
Topics: Animals; Benzaldehydes; Computer Simulation; Coumarins; Diabetes Mellitus, Experimental; Esters; Hydantoins; Hypoglycemic Agents; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Models, Molecular; Oxazoles; PPAR gamma; Rats; Rats, Wistar; Rosiglitazone; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Streptozocin; Thiazolidinediones | 2012 |