rosiglitazone has been researched along with gw 7647 in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 17 (70.83) | 24.3611 |
| 2020's | 5 (20.83) | 2.80 |
| Authors | Studies |
|---|---|
| Abad, MC; Askari, HB; De, D; Gaul, MD; Geisler, JG; Kasturi, J; Kemmerer, M; Kim, AJ; Lenhard, JM; Lin, L; Liu, J; O'Neill, JC; Patch, RJ; Player, MR; Rentzeperis, D; Searle, LL; Zhu, X | 1 |
| Carta, G; Fayne, D; Lloyd, DG; Nevin, DK; Peters, MB | 1 |
| Capelli, D; Di Giovanni, C; Faliti, S; Fracchiolla, G; Iacobazzi, V; Infantino, V; Laghezza, A; Lavecchia, A; Loiodice, F; Montanari, R; Piemontese, L; Pochetti, G; Tortorella, P | 1 |
| Büssow, K; de Groot, JC; Kawamoto, K; Krausze, J; Sauer, S; Schroeder, FC; Weidner, C | 1 |
| Gege, C; Hoffmann, T; Schlüter, T | 1 |
| Elguero, J; Fresno, N; Goya, P; Macías-González, M; Pavón, FJ; Pérez-Fernández, R; Rodríguez de Fonseca, F; Romero-Cuevas, M; Sanz-Camacho, P; Torres-Zaguirre, A | 1 |
| Angioni, C; Blöcher, R; Boß, M; Brüggerhoff, A; Brüne, B; Diehl, O; Geisslinger, G; Göbel, T; Grundmann, M; Hartmann, M; Heering, J; Kahnt, AS; Kaiser, A; Kostenis, E; Lamers, C; Merk, D; Proschak, E; Schader, T; Schubert-Zsilavecz, M; Steinhilber, D; Weizel, L; Wittmann, SK; Wurglics, M | 1 |
| Hashimoto, Y; Ishikawa, M; Makishima, M; Noguchi-Yachide, T; Okazaki, S; Sakai, T; Yamaguchi, T | 1 |
| Hashimoto, Y; Ishikawa, M; Makishima, M; Noguchi-Yachide, T; Okazaki, S; Shioi, R; Yamaguchi, T | 2 |
| Deng, F; Li, Y; Li, Z; Zhang, D; Zhang, L; Zhou, Z | 1 |
| Ammazzalorso, A; Amoroso, R; Brunetti, L; Bruno, I; Cama, A; Capone, F; Cerchia, C; De Filippis, B; Fantacuzzi, M; Ferrante, C; Florio, R; Giampietro, L; Laghezza, A; Lavecchia, A; Loiodice, F; Maccallini, C; Recinella, L; Tortorella, P; Verginelli, F | 1 |
| Arnesen, H; Haj-Yasein, NN; Hansen, TV; Matthews, J; Nebb, HI; Paulsen, SM; Soedling, H; Sylte, I; Sæther, T; Tungen, JE | 1 |
| Gu, YH; Hou, DL; Li, HB; Liu, K; Qi, X; Xu, QL; Zhao, X | 1 |
| Cai, Z; Han, J; Li, Z; Ren, Q; Wang, B; Zhang, L; Zhou, Z | 1 |
| Cai, Z; Deng, L; Geng, X; Hu, L; Jiao, S; Li, Z; Ren, Q; Wang, B; Yang, Y; Zhang, L; Zhou, Z | 1 |
| Cai, Z; Chen, L; He, Y; Li, Z; Yang, B; Zhang, C; Zhang, L; Zhou, Z | 1 |
| Alves, PS; Bhattacharyya, M; Brand, GD; Cummins, CL; Ferreira, TAM; Grouleff, J; Krause, H; Leite, JRSA; Liu, J; Magomedova, L; Moreira, DC; Nogueira, PCN; Oliveira, AS; Poda, G; Queiroz, FJG; Romeiro, LAS; Sahin, C; Silveira, ER; Tiefenbach, J; Uehling, D | 1 |
| Balaguer, P; Carlavan, I; Lemaire, G; Nicolas, JC; Perrin, A; Pillon, A; Seimandi, M; Vignon, F; Voegel, JJ | 1 |
| Aleshin, S; Grabeklis, S; Hanck, T; Reiser, G; Sergeeva, M | 1 |
| Bezaire, V; Langin, D; Mairal, A; Mazzucotelli, A; Montastier, E; Ribet, C; Valle, C; Viguerie, N | 1 |
| Li, N; Ramji, DP; Salter, RC | 1 |
| Decsi, T; Liebisch, G; Marosvölgyi, T; Mihály, J; Rühl, R; Schmitz, G; Weiss, K | 1 |
| Brunström, B; Kärrman, A; Mattsson, A; Pinto, R | 1 |
24 other study(ies) available for rosiglitazone and gw 7647
| Article | Year |
|---|---|
Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.
Topics: Administration, Oral; Animals; Binding, Competitive; Biological Availability; Crystallography, X-Ray; Diabetes Mellitus; Dogs; ERRalpha Estrogen-Related Receptor; Ethers; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Ligands; Macaca fascicularis; Male; Mice; Mice, Knockout; Models, Molecular; Molecular Structure; Obesity; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Structure-Activity Relationship; Thiazolidinediones; Triglycerides | 2011 |
Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.
Topics: Benzamides; Binding, Competitive; Databases, Factual; Fluorescence Polarization; Fluorescence Resonance Energy Transfer; HEK293 Cells; Humans; Models, Molecular; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR delta; PPAR gamma; Protein Conformation; Pyrazoles; Pyrrolidinones; Structure-Activity Relationship; Thiazoles; Thiobarbiturates | 2012 |
New 2-(aryloxy)-3-phenylpropanoic acids as peroxisome proliferator-activated receptor α/γ dual agonists able to upregulate mitochondrial carnitine shuttle system gene expression.
Topics: Calorimetry; Carnitine O-Palmitoyltransferase; Cell Line, Tumor; Crystallography, X-Ray; Humans; Membrane Transport Proteins; Mitochondrial Proteins; Molecular Docking Simulation; PPAR alpha; PPAR gamma; Propionates; Protein Conformation; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Transcriptional Activation; Up-Regulation | 2013 |
Structural characterization of amorfrutins bound to the peroxisome proliferator-activated receptor γ.
Topics: Crystallography, X-Ray; Drug Partial Agonism; Genes, Reporter; HEK293 Cells; Humans; Molecular Structure; PPAR gamma; Salicylates; Stereoisomerism | 2013 |
Identification of the first inverse agonist of retinoid-related orphan receptor (ROR) with dual selectivity for RORβ and RORγt.
Topics: Benzeneacetamides; Drug Inverse Agonism; Fluorescence Resonance Energy Transfer; Humans; Ligands; Nuclear Receptor Subfamily 1, Group F, Member 2; Nuclear Receptor Subfamily 1, Group F, Member 3; Protein Binding; Th17 Cells; Thiazoles; Tretinoin | 2014 |
Novel Oxazolidinone-Based Peroxisome Proliferator Activated Receptor Agonists: Molecular Modeling, Synthesis, and Biological Evaluation.
Topics: Animals; Appetite Depressants; Dose-Response Relationship, Drug; Eating; Ligands; Models, Molecular; Molecular Conformation; Oxazoles; PPAR alpha; PPAR gamma; Rats; Structure-Activity Relationship | 2015 |
N-Benzylbenzamides: A Novel Merged Scaffold for Orally Available Dual Soluble Epoxide Hydrolase/Peroxisome Proliferator-Activated Receptor γ Modulators.
Topics: 3T3 Cells; Administration, Oral; Animals; Benzamides; Chlorocebus aethiops; COS Cells; Diabetes Mellitus, Type 2; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Epoxide Hydrolases; Humans; Hypertension; In Vitro Techniques; Metabolic Syndrome; Mice; Microsomes, Liver; PPAR gamma; Rats; Structure-Activity Relationship | 2016 |
Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamides as novel acetyl-CoA carboxylase 2 (ACC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.
Topics: Acetamides; Acetyl-CoA Carboxylase; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Humans; Molecular Structure; Oxadiazoles; PPAR alpha; PPAR delta; Structure-Activity Relationship | 2016 |
Structure-activity relationship studies of non-carboxylic acid peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.
Topics: Acetamides; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; PPAR alpha; PPAR delta; Structure-Activity Relationship | 2016 |
Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists.
Topics: Acetamides; Binding Sites; Genes, Reporter; HEK293 Cells; Humans; Ligands; PPAR alpha; PPAR delta; Protein Binding; Stereoisomerism; Thiazolidinediones | 2017 |
Design, synthesis, and biological evaluation of novel pan agonists of FFA1, PPARγ and PPARδ.
Topics: Animals; CHO Cells; Cricetulus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Design; Glucose Tolerance Test; HEK293 Cells; Hep G2 Cells; Humans; Hypoglycemic Agents; Male; Mice; Mice, Inbred ICR; Mice, Obese; Models, Molecular; Molecular Structure; PPAR delta; PPAR gamma; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2018 |
Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.
Topics: | 2019 |
Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist.
Topics: Fatty Acids; Humans; Isoxazoles; Models, Molecular; PPAR alpha | 2019 |
Design, synthesis, and biological evaluation of a novel dual peroxisome proliferator-activated receptor alpha/delta agonist for the treatment of diabetic kidney disease through anti-inflammatory mechanisms.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Humans; Hypoglycemic Agents; Male; Molecular Structure; NF-kappa B; PPAR alpha; PPAR gamma; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship | 2021 |
Discovery of the first-in-class dual PPARδ/γ partial agonist for the treatment of metabolic syndrome.
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Dose-Response Relationship, Drug; Drug Discovery; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Molecular Structure; Organic Chemicals; PPAR delta; PPAR gamma; Rats; Rats, Sprague-Dawley; Streptozocin; Structure-Activity Relationship | 2021 |
Discovery of new and highly effective quadruple FFA1 and PPARα/γ/δ agonists as potential anti-fatty liver agents.
Topics: Animals; Chenodeoxycholic Acid; Drug Discovery; Gene Expression Regulation; Humans; Hypoglycemic Agents; Liver Cirrhosis; Male; Mice, Inbred C57BL; Mice, Inbred ICR; Models, Molecular; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Peroxisome Proliferator-Activated Receptors; Protein Binding; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2022 |
Design, synthesis, and biological evaluation of novel dual FFA1 and PPARδ agonists possessing phenoxyacetic acid scaffold.
Topics: Acetates; Animals; Dose-Response Relationship, Drug; Drug Design; Humans; Hypoglycemic Agents; Male; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Molecular Structure; PPAR delta; Receptors, G-Protein-Coupled; Structure-Activity Relationship | 2022 |
Phenolic Lipids Derived from Cashew Nut Shell Liquid to Treat Metabolic Diseases.
Topics: 3T3-L1 Cells; Anacardic Acids; Anacardium; Animals; Drug Design; Gene Expression; HEK293 Cells; Humans; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Nuts; PPAR alpha; PPAR delta; PPAR gamma; Protein Domains; Zebrafish | 2022 |
Differential responses of PPARalpha, PPARdelta, and PPARgamma reporter cell lines to selective PPAR synthetic ligands.
Topics: Anilides; Benzhydryl Compounds; Butyrates; DNA-Binding Proteins; Epoxy Compounds; Genes, Reporter; HeLa Cells; Humans; Inhibitory Concentration 50; Ligands; Luciferases; Peroxisome Proliferator-Activated Receptors; Phenylurea Compounds; PPAR alpha; PPAR delta; PPAR gamma; Rosiglitazone; Saccharomyces cerevisiae Proteins; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection | 2005 |
Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels.
Topics: Animals; Animals, Newborn; Astrocytes; Biomarkers; Brain; Butyrates; Cells, Cultured; Cyclooxygenase 2; Drug Combinations; Gene Expression Regulation, Enzymologic; Glial Fibrillary Acidic Protein; Lipopolysaccharides; Peroxisome Proliferator-Activated Receptors; Phenoxyacetates; Phenylurea Compounds; PPAR alpha; PPAR delta; PPAR gamma; PPAR-beta; Protein Isoforms; Rats; Rosiglitazone; Thiazolidinediones; Time Factors | 2009 |
Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes.
Topics: Adipocytes, White; Butyrates; Cells, Cultured; Fatty Acids; Female; Gene Expression Profiling; Gene Expression Regulation; Glucose; Glycolysis; Humans; Hypoglycemic Agents; Lipid Metabolism; Models, Biological; Oligonucleotide Array Sequence Analysis; Oxidation-Reduction; Phenylurea Compounds; PPAR alpha; PPAR gamma; Rosiglitazone; Thiazolidinediones | 2010 |
Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs.
Topics: Blotting, Western; Butyrates; Cell Line; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Humans; Hydrocarbons, Fluorinated; Interferon-gamma; Liver X Receptors; Macrophages; Orphan Nuclear Receptors; Peroxisome Proliferator-Activated Receptors; Phenylurea Compounds; Rosiglitazone; Simvastatin; STAT1 Transcription Factor; Sulfonamides; Thiazolidinediones; Transfection | 2011 |
Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice.
Topics: Acetyltransferases; Animals; Benzoates; Butyrates; Fatty Acid Elongases; Fatty Acids; Female; Gene Expression; Hydrocarbons, Fluorinated; Liver; Liver X Receptors; Mice; Mice, Inbred C57BL; Organic Chemicals; Orphan Nuclear Receptors; Peroxisome Proliferator-Activated Receptors; Phenylurea Compounds; Phospholipids; Receptors, Retinoic Acid; Rosiglitazone; Stearoyl-CoA Desaturase; Sulfonamides; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones | 2011 |
Metabolic Profiling of Chicken Embryos Exposed to Perfluorooctanoic Acid (PFOA) and Agonists to Peroxisome Proliferator-Activated Receptors.
Topics: Animals; Blood Chemical Analysis; Butyrates; Caprylates; Chick Embryo; Embryonic Development; Fluorocarbons; Liver; Metabolomics; Phenylurea Compounds; PPAR alpha; PPAR gamma; Rosiglitazone; Thiazolidinediones | 2015 |