Page last updated: 2024-08-25

rosiglitazone and bexarotene

rosiglitazone has been researched along with bexarotene in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's6 (40.00)29.6817
2010's6 (40.00)24.3611
2020's2 (13.33)2.80

Authors

AuthorsStudies
Abad, MC; Askari, HB; De, D; Gaul, MD; Geisler, JG; Kasturi, J; Kemmerer, M; Kim, AJ; Lenhard, JM; Lin, L; Liu, J; O'Neill, JC; Patch, RJ; Player, MR; Rentzeperis, D; Searle, LL; Zhu, X1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Gellrich, L; Heering, J; Kaiser, A; Kalinowsky, L; Kilu, W; Merk, D; Ohrndorf, J; Pollinger, J; Proschak, E; Schierle, S; Schmidt, J1
Chaikuad, A; Gellrich, L; Heitel, P; Kaiser, A; Knapp, S; Merk, D; Ohrndorf, J; Pollinger, J; Schierle, S1
Fujihara, M; Ito, S; Kakuta, H; Kawasaki, M; Makishima, M; Motoyama, T; Nakano, S; Takamura, Y; Watanabe, M; Yamada, S1
Bischoff, ED; Boehm, MF; Cesario, RM; Crombie, DL; Davies, PJ; Hamann, LG; Heyman, RA; Jow, L; Mondon, CE; Mukherjee, R; Nadzan, AM; Paterniti, JR1
Blanchard, SG; Furfine, ES; Ittoop, O; Jain, RG; Lenhard, JM; Orband-Miller, LA; Paulik, MA; Weiel, JE1
Bissonnette, RP; Cesario, RM; Lamph, WW; Stone, J; Yen, WC1
Mohler, DL; Shen, G1
Greer, JP; Koyama, T; Sepmeyer, JA; Zic, JA1
Baggstrom, MQ; Fracasso, PM; Govindan, R; Read, WL1
Berenz, A; Haugen, BR; Hays, WR; Klopper, JP; Loi, M; Pugazhenthi, U; Said, S; Sharma, V1
Amagaya, S; Inoue, M; Kotani, H; Mizukami, H; Tanabe, H1
Chen, JY; Chi, CW; Hsu, YC; Lee, CH; Lee, HC; Wang, JJ1

Reviews

1 review(s) available for rosiglitazone and bexarotene

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for rosiglitazone and bexarotene

ArticleYear
Open-label pilot study of combination therapy with rosiglitazone and bexarotene in the treatment of cutaneous T-cell lymphoma.
    Journal of the American Academy of Dermatology, 2007, Volume: 56, Issue:4

    Topics: Aged; Anticarcinogenic Agents; Bexarotene; Biopsy, Needle; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Immunohistochemistry; Lymphoma, T-Cell, Cutaneous; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Pilot Projects; Risk Assessment; Rosiglitazone; Single-Blind Method; Survival Analysis; Tetrahydronaphthalenes; Thiazolidinediones; Treatment Outcome

2007
A phase I study of bexarotene and rosiglitazone in patients with refractory cancers.
    Chemotherapy, 2008, Volume: 54, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bexarotene; Female; Humans; Male; Middle Aged; Neoplasms; Rosiglitazone; Tetrahydronaphthalenes; Thiazolidinediones

2008

Other Studies

12 other study(ies) available for rosiglitazone and bexarotene

ArticleYear
Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.
    Journal of medicinal chemistry, 2011, Feb-10, Volume: 54, Issue:3

    Topics: Administration, Oral; Animals; Binding, Competitive; Biological Availability; Crystallography, X-Ray; Diabetes Mellitus; Dogs; ERRalpha Estrogen-Related Receptor; Ethers; Female; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Ligands; Macaca fascicularis; Male; Mice; Mice, Knockout; Models, Molecular; Molecular Structure; Obesity; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Structure-Activity Relationship; Thiazolidinediones; Triglycerides

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.
    Journal of medicinal chemistry, 2019, 02-28, Volume: 62, Issue:4

    Topics: Animals; HEK293 Cells; Hep G2 Cells; Humans; Male; Mice, Inbred C57BL; Microsomes, Liver; Molecular Structure; Peroxisome Proliferator-Activated Receptors; Pyrimidines; Rats; Retinoid X Receptors; Structure-Activity Relationship

2019
A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.
    ACS medicinal chemistry letters, 2019, Sep-12, Volume: 10, Issue:9

    Topics:

2019
Discovery of a "Gatekeeper" Antagonist that Blocks Entry Pathway to Retinoid X Receptors (RXRs) without Allosteric Ligand Inhibition in Permissive RXR Heterodimers.
    Journal of medicinal chemistry, 2021, 01-14, Volume: 64, Issue:1

    Topics: Allosteric Regulation; Circular Dichroism; Crystallography, X-Ray; Dimerization; Ligands; Retinoid X Receptors

2021
Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists.
    Nature, 1997, Mar-27, Volume: 386, Issue:6623

    Topics: Animals; Bexarotene; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Female; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Insulin Resistance; Ligands; Mice; Mice, Inbred C57BL; Mice, Obese; Nicotinic Acids; Obesity; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Rosiglitazone; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection

1997
HIV protease inhibitors block adipogenesis and increase lipolysis in vitro.
    Antiviral research, 2000, Volume: 47, Issue:2

    Topics: Adipocytes; Animals; Azo Compounds; Bexarotene; Carbamates; Carrier Proteins; Cell Differentiation; Cells, Cultured; Coloring Agents; Fatty Acid-Binding Proteins; Furans; HIV Protease Inhibitors; Indinavir; Insulin; Lipolysis; Lipoprotein Lipase; Nelfinavir; Neoplasm Proteins; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Ritonavir; RNA, Messenger; Rosiglitazone; Saquinavir; Stem Cells; Sulfonamides; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides

2000
Differentiation and growth inhibition mediated via the RXR:PPARgamma heterodimer in colon cancer.
    Cancer letters, 2006, Aug-28, Volume: 240, Issue:2

    Topics: Animals; Anticarcinogenic Agents; Bexarotene; Cell Differentiation; Cell Proliferation; Colonic Neoplasms; Cyclooxygenase 2; Fibrinolytic Agents; Humans; Male; Membrane Proteins; Mice; Mice, Nude; PPAR gamma; Prostaglandin D2; Retinoid X Receptors; Rosiglitazone; Tetrahydronaphthalenes; Thiazolidinediones; Transplantation, Heterologous; Tumor Cells, Cultured

2006
The synthesis of tethered ligand dimers for PPARgamma-RXR protein heterodimers.
    Organic & biomolecular chemistry, 2006, Jun-07, Volume: 4, Issue:11

    Topics: Bexarotene; Dimerization; Ligands; PPAR gamma; Retinoid X Receptors; Rosiglitazone; Tetrahydronaphthalenes; Thiazolidinediones

2006
Retinoid and thiazolidinedione therapies in melanoma: an analysis of differential response based on nuclear hormone receptor expression.
    Molecular cancer, 2009, Mar-06, Volume: 8

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzoates; Bexarotene; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Ligands; Melanoma; Mice; PPAR gamma; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; Retinoids; RNA, Small Interfering; Rosiglitazone; Tetrahydronaphthalenes; Thiazolidinediones; Xenograft Model Antitumor Assays

2009
A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:1

    Topics: 3T3-L1 Cells; Animals; Anticarcinogenic Agents; Bexarotene; Biphenyl Compounds; Caco-2 Cells; Dimerization; Humans; Lignans; Liver X Receptors; Magnolia; Mice; Orphan Nuclear Receptors; Plant Extracts; PPAR gamma; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; RNA, Messenger; Rosiglitazone; Signal Transduction; Tetrahydronaphthalenes; Thiazolidinediones

2012
Combination of peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists induces sodium/iodide symporter expression and inhibits cell growth of human thyroid cancer cells.
    Journal of the Chinese Medical Association : JCMA, 2020, Volume: 83, Issue:10

    Topics: Bexarotene; Cell Line, Tumor; Cell Proliferation; Drug Therapy, Combination; Epithelial-Mesenchymal Transition; Humans; PPAR gamma; Retinoid X Receptors; Rosiglitazone; Symporters; Thyroid Neoplasms; Tumor Hypoxia

2020