romidepsin and largazole

romidepsin has been researched along with largazole* in 1 studies

Other Studies

1 other study(ies) available for romidepsin and largazole

Article	Year
Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability. Bioorganic & medicinal chemistry, 2011, Jun-15, Volume: 19, Issue:12 The total synthesis of largazole and four analogues is reported. All analogues were nanomolar HDAC inhibitors. The antiproliferative activity is driven by lipophilicity and cell permeability. In murine liver homogenates, largazole is rapidly metabolized (half-life ≤5 min) to the thiol which has a half-life of 51 min. Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Depsipeptides; Drug Stability; Enzyme Activation; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Mice; Molecular Structure; Structure-Activity Relationship; Thiazoles	2011

Article

Year

Total synthesis of largazole and analogues: HDAC inhibition, antiproliferative activity and metabolic stability.

Bioorganic & medicinal chemistry, 2011, Jun-15, Volume: 19, Issue:12

The total synthesis of largazole and four analogues is reported. All analogues were nanomolar HDAC inhibitors. The antiproliferative activity is driven by lipophilicity and cell permeability. In murine liver homogenates, largazole is rapidly metabolized (half-life ≤5 min) to the thiol which has a half-life of 51 min.

Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Depsipeptides; Drug Stability; Enzyme Activation; HeLa Cells; Histone Deacetylase Inhibitors; Humans; Mice; Molecular Structure; Structure-Activity Relationship; Thiazoles

2011