rolipram and h 89

Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship

Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

Topics: Animals; Arachidonic Acid; Enzyme Inhibitors; In Vitro Techniques; Inositol Phosphates; Isoquinolines; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphodiesterase Inhibitors; Phospholipase D; Phospholipases; Phospholipases A; Protein Kinase Inhibitors; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Signal Transduction; Sulfonamides; Type C Phospholipases

Topics: Adenine; Androstadienes; Animals; Ascitic Fluid; Cell Aggregation; Cells, Cultured; Chemotaxis, Leukocyte; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Glyburide; Isoquinolines; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Potassium Channels; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram; Sulfonamides; Wortmannin

Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Animals; Aorta; Calcium; Cardiotonic Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Isoproterenol; Isoquinolines; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphodiesterase Inhibitors; Pyrazines; Pyrrolidinones; Rats; Rats, Wistar; Rolipram; Signal Transduction; Sulfonamides; Thionucleotides

Topics: Acetates; Animals; Cell Aggregation; Cyclic AMP; Epoprostenol; Iloprost; Imidazoles; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Peritoneal Cavity; Phenoxyacetates; Pyrrolidinones; Rats; Rolipram; Second Messenger Systems; Sulfonamides

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenoleukodystrophy; Animals; Astrocytes; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytokines; Enzyme Inhibitors; Fatty Acids; Genetic Linkage; Interleukin-1; Isoquinolines; Neuroglia; Oxidation-Reduction; Protein Kinase Inhibitors; Pyrrolidinones; Rats; Rolipram; Sulfonamides; Tumor Necrosis Factor-alpha; X Chromosome

Topics: Animals; Bradykinin; Carrageenan; Cyclic AMP; Cyclic GMP; Dinoprostone; Dopamine; Hyperalgesia; Inflammation; Interleukin-1; Interleukin-6; Interleukin-8; Isoquinolines; Male; Oxadiazoles; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Rolipram; Second Messenger Systems; Sulfonamides; Tumor Necrosis Factor-alpha

Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Flow Cytometry; Hemocytes; Isoproterenol; Isoquinolines; Microscopy, Confocal; Naphthalenes; Norepinephrine; Ostreidae; Phagocytosis; Phenylephrine; Phosphodiesterase Inhibitors; Prazosin; Propranolol; Protein Kinase C; Receptors, Adrenergic, beta; Rolipram; Signal Transduction; Sulfonamides

Topics: Adenosine Triphosphatases; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; Isoquinolines; Lymphocytes; Microscopy, Fluorescence; Milrinone; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rolipram; Sulfonamides; Thapsigargin; Time Factors

Topics: 8-Bromo Cyclic Adenosine Monophosphate; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Guanine Nucleotide Exchange Factors; Humans; Immunosuppressive Agents; Interleukin-5; Isoquinolines; Lymphocyte Activation; Phosphorylation; rap1 GTP-Binding Proteins; Rolipram; Sulfonamides; T-Lymphocytes

Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diazepam; Flumazenil; Hypothalamus; Isoquinolines; Male; Phosphodiesterase Inhibitors; Pituitary Gland; Rats; Rats, Sprague-Dawley; Rolipram; Sulfonamides

Topics: Action Potentials; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activators; Enzyme Inhibitors; Epilepsy; Hippocampus; Isoquinolines; Male; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Rolipram; Seizures; Sulfonamides; Thionucleotides

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Animals, Newborn; Arrestins; beta-Arrestins; Cell Line; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Green Fluorescent Proteins; Humans; Isoquinolines; Luminescent Proteins; Models, Biological; Myocardium; Pertussis Toxin; Phosphoric Diester Hydrolases; Phosphorylation; Rats; Receptors, Adrenergic, beta; Rolipram; Signal Transduction; Sulfonamides; Time Factors; Transfection

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Decidua; Drug Synergism; Endometrium; Enzyme Inhibitors; Feedback, Physiological; Female; Gene Expression; Humans; Insulin-Like Growth Factor Binding Protein 1; Isoenzymes; Isoquinolines; Middle Aged; Prolactin; Relaxin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rolipram; Signal Transduction; Stromal Cells; Sulfonamides

Topics: Activating Transcription Factor 1; Adaptor Proteins, Signal Transducing; Adenosine Monophosphate; Adenoviridae; Albuterol; Animals; Arachidonic Acid; Carrier Proteins; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; DNA-Binding Proteins; Drug Interactions; Epithelial Cells; Gene Expression Regulation; Gene Transfer Techniques; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Intracellular Signaling Peptides and Proteins; Isoquinolines; Phosphorylation; Rabbits; Rolipram; Sulfonamides; Transcription Factors; Tritium

Topics: Amino Acids; Animals; Anticonvulsants; Avoidance Learning; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclopropanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Isoquinolines; Male; Memory; Mice; Reaction Time; Receptors, Metabotropic Glutamate; Rolipram; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Xanthenes

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Carbazoles; Colforsin; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclooxygenase 2; DNA; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunoblotting; Indoles; Isoquinolines; Jurkat Cells; Luciferases; Membrane Proteins; NFATC Transcription Factors; Nuclear Proteins; Plasmids; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases; Protein Binding; Pyrroles; RNA, Messenger; Rolipram; Sulfonamides; T-Lymphocytes; Transcription Factors; Transcriptional Activation; Transfection

Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adult; Anti-Ulcer Agents; Bucladesine; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Gastric Mucosa; Humans; Isoenzymes; Isoquinolines; Neutrophils; Rolipram; Sulfonamides; Superoxides; Triazines

Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adaptor Proteins, Signal Transducing; Adenylyl Cyclases; Buffers; Cell Line; Cell Membrane; Computer Simulation; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Humans; Ion Channel Gating; Ion Channels; Isoquinolines; Kinetics; Models, Biological; Nucleotides, Cyclic; Peptides; Phosphodiesterase Inhibitors; Prostaglandins; Protein Kinase Inhibitors; Rolipram; Signal Transduction; Sulfonamides

Topics: Adrenergic beta-2 Receptor Agonists; Animals; Asthma; Butadienes; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dinoprostone; Enzyme Induction; Humans; Isoquinolines; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Muscle Relaxation; Nitriles; Pertussis Toxin; Phosphodiesterase 4 Inhibitors; Rabbits; Receptors, G-Protein-Coupled; Rolipram; Signal Transduction; Sulfonamides; Trachea

Topics: Animals; Cell Line; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Enteroendocrine Cells; Glucagon-Like Peptide 1; Glucose; Isoenzymes; Isoquinolines; Mice; Phosphodiesterase 3 Inhibitors; Protein Kinase Inhibitors; Rats; Rolipram; Sulfonamides

Topics: Animals; Capillary Permeability; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dideoxyadenosine; Endothelium, Vascular; Enzyme Inhibitors; Female; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Inflammation; Isoquinolines; Lipopolysaccharides; Mesentery; Peptide Fragments; Perfusion; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Rolipram; Sulfonamides; Venules

Topics: Adenylyl Cyclases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bucladesine; Calcium Signaling; Cell Line; Cell Membrane; Ceramides; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Genes, Reporter; Guanosine Triphosphate; Imidazoles; Indoles; Interleukin-10; Isoquinolines; Lipopolysaccharides; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Response Elements; Ribosomal Protein S6 Kinases, 90-kDa; Rolipram; Signal Transduction; Sulfonamides; Transfection; Tumor Necrosis Factor-alpha

Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Annexin A5; Apoptosis; Bicarbonates; Caspase 3; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cytochromes c; Epithelium, Corneal; Estradiol; Isoquinolines; Phosphodiesterase 4 Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Rolipram; Staurosporine; Sulfonamides

Topics: 1-Methyl-3-isobutylxanthine; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Glioblastoma; Guanine Nucleotide Exchange Factors; Humans; Isoquinolines; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Rolipram; Shelterin Complex; Signal Transduction; Sulfonamides; Telomere-Binding Proteins; Theophylline

Topics: Cell Line, Tumor; Cell Proliferation; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Progression; Down-Regulation; Humans; Hydrogen Peroxide; Isoquinolines; Male; Phosphodiesterase 4 Inhibitors; Prostatic Neoplasms; Protein Kinase Inhibitors; Rolipram; Sulfonamides

Topics: A Kinase Anchor Proteins; Antineoplastic Agents; Calcium; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Survival; Culture Media; Cyclic AMP; Cytosol; Enzyme Activation; Humans; Isoquinolines; K562 Cells; Lymphocytes; Mitochondria; Mitochondrial Proteins; Mollusk Venoms; Oxocins; Phosphodiesterase 4 Inhibitors; Rolipram; Sulfonamides; Thapsigargin

Topics: Actins; Brain; Capillary Permeability; Carbazoles; Cells, Cultured; Cilostazol; Claudin-5; Dipyridamole; Drug Interactions; Electric Impedance; Endothelial Cells; Histamine; Humans; Isoquinolines; Phosphodiesterase Inhibitors; Protein Kinase Inhibitors; Pyrroles; Rolipram; Sulfonamides; Tetrazoles