rokitamycin and quinone

rokitamycin has been researched along with quinone* in 1 studies

Other Studies

1 other study(ies) available for rokitamycin and quinone

Article	Year
Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3-O-(3-Aryl-2-propenyl)leucomycin analogues. Bioorganic & medicinal chemistry, 2008, Apr-15, Volume: 16, Issue:8 The design and synthesis of 16-membered macrolides modified at the C-3 position are described. Starting from fully protected intermediate (5), appropriate modifications including Heck reaction were performed to furnish 3-O-(3-aryl-2-propenyl)leucomycin A(7) analogues (9a-9m). These leucomycin A(7) derivatives showed improved in vitro antibacterial activities against clinically important pathogens including erythromycin-resistant Streptococcus pneumoniae (ERSP). SAR analysis of derivatives modified at the C-3 and C-3'' positions suggested that single modification at C-3 or C-3'' was effective for in vitro antibacterial activity. Topics: Anti-Bacterial Agents; Benzoquinones; Crystallography, X-Ray; Drug Design; Kitasamycin; Miocamycin; Models, Molecular; Molecular Structure; Streptococcus; Structure-Activity Relationship	2008

Article

Year

Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3-O-(3-Aryl-2-propenyl)leucomycin analogues.

Bioorganic & medicinal chemistry, 2008, Apr-15, Volume: 16, Issue:8

The design and synthesis of 16-membered macrolides modified at the C-3 position are described. Starting from fully protected intermediate (5), appropriate modifications including Heck reaction were performed to furnish 3-O-(3-aryl-2-propenyl)leucomycin A(7) analogues (9a-9m). These leucomycin A(7) derivatives showed improved in vitro antibacterial activities against clinically important pathogens including erythromycin-resistant Streptococcus pneumoniae (ERSP). SAR analysis of derivatives modified at the C-3 and C-3'' positions suggested that single modification at C-3 or C-3'' was effective for in vitro antibacterial activity.

Topics: Anti-Bacterial Agents; Benzoquinones; Crystallography, X-Ray; Drug Design; Kitasamycin; Miocamycin; Models, Molecular; Molecular Structure; Streptococcus; Structure-Activity Relationship

2008