Compounds > rofecoxib
Page last updated: 2024-08-16

rofecoxib and indomethacin

rofecoxib has been researched along with indomethacin in 113 studies

Research

Studies (113)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (6.19)18.2507
2000's83 (73.45)29.6817
2010's23 (20.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Brideau, C; Chan, CC; Charleson, S; Cromlish, W; Ethier, D; Evans, JF; Ford-Hutchinson, AW; Gauthier, JY; Gordon, R; Gresser, M; Guay, J; Kargman, S; Kennedy, B; Leblanc, Y; Léger, S; Mancini, J; O'Neill, GP; Ouellet, M; Percival, MD; Perrier, H; Prasit, P; Riendeau, D; Rodger, I; Wang, Z; Zamboni, R1
Boyce, S; Brideau, C; Chan, CC; Charleson, S; Gordon, R; Grimm, E; Guay, J; Leblanc, Y; Léger, S; Li, CS; Prasit, P; Riendeau, D; Roy, P; Visco, D; Wang, Z; Webb, J; Xu, LJ1
Black, WC; Brideau, C; Chan, CC; Charleson, S; Claveau, D; Cromlish, WA; Gauthier, JY; Gordon, R; Greig, G; Grimm, E; Guay, J; Lau, CK; Li, CS; Prasit, P; Riendeau, D; Thérien, M; Visco, DM; Wong, E; Xu, L1
Brideau, C; Chan, CC; Charleson, S; Cromlish, WA; Ethier, D; Gauthier, JY; Gordon, R; Guay, J; Kargman, S; Lau, CK; Li, CS; Prasit, P; Riendeau, D; Thérien, M; Visco, DM; Xu, L1
Byun, YJ; Choi, JK; Chung, S; Ha, JY; Kim, JK; Kim, JY; Lee, CH; Lim, KM; Noh, MS; Shin, SS1
Crespo, MI; Feixas, J; Godessart, N; Jiménez, JM; Puig, C; Soca, L1
Cabré, F; Campos, J; Entrena, A; Espinosa, A; Gallo, MA; García, L; Mauleón, D; Palomer, A; Pascual, J; Trujillo, MA1
Haruta, J; Hashimoto, H; Imamura, K; Wakitani, K1
Aubin, Y; Brideau, C; Chan, CC; Chauret, N; Gordon, R; Leblanc, Y; Li, CS; Nicoll-Griffith, DA; Prasit, P; Riendeau, D; Roy, P; Silva, JM; Visco, DM; Wang, Z; Webb, J; Xu, L; Yergey, JA1
Bohlin, L; Huss, U; Perera, P; Ringbom, T; Vasänge, M1
Borst, P; de Haas, M; Kuil, A; Reid, G; van der Heijden, I; Wielinga, P; Wijnholds, J; Zelcer, N1
Alfón, J; Almansa, C; Bartrolí, J; Carceller, E; Cavalcanti, FL; de Arriba, AF; Escamilla, I; García-Rafanell, J; Gómez, LA; Merlos, M; Miralles, A; Soliva, R1
Casturi, SR; Gopalakrishnan, B; Kalleda, S; Madan, M; Malde, A; Mamidi, NV; Mullangi, R; Padakanti, S; Pal, M; Pattabiraman, VR; Vanguri, A; Yeleswarapu, KR1
Byun, Y; Choi, JK; Choi, YH; Chung, S; Jeong, YS; Kim, JK; Kim, JY; Koh, HJ; Lee, KW; Lim, KM; Moh, JH; Noh, MS; Oh, YI; Park, YH; Shin, SS1
Li, CS; Mancini, JA; Ouellet, M; Riendeau, D; Salem, M; Styhler, A1
Anzini, M; Biava, M; Botta, M; Cappelli, A; Makovec, F; Manetti, F; Porretta, GC; Rossi, A; Sautebin, L; Vomero, S1
Backlund, A; Bohlin, L; Gottfries, J; Larsson, J1
Deng, S; Jensen, JC; Palu, 'K; Su, CX; West, BJ; Zhou, BN1
Bhardwaj, A; Kaur, S; Kumar, S; Mittal, A; Singh, P1
Jarrott, B; Manallack, DT; Williams, SJ; Zanatta, SD1
Banoğlu, E; Costantino, G; Dündar, Y; Entrena, A; Labeaga, L; Ledo, F; Noyanalpan, N; Nuñez, MT; Sahin, MF; Unlü, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Banoğlu, E; Costantino, G; Entrena, A; Eren, G; Labeaga, L; Ledo, F; Nuñez, MT; Sahin, MF; Unlü, S1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Dong, H; Hammock, BD; Hwang, SH; Liu, JY; Morisseau, C; Wagner, KM; Wecksler, AT1
Bolm, C; Buschmann, H; Park, SJ1
Blobaum, AL; Crews, BC; Daniel, CM; Ghebreselasie, K; Kingsley, PJ; Liedtke, AJ; Marnett, LJ1
Bali, A; Deb, PK; Ohri, R1
Bolm, C; Buschmann, H; Chen, XY; De Rosa, M; Park, SJ1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bali, A; Chaudhari, BB; Sharma, R1
Bonanni, D; Boschi, D; Carnovale, IM; Cena, C; Costale, A; Giraudo, A; Lolli, ML; Marini, E; Oliaro-Bosso, S; Pippione, AC; Pors, K; Sadiq, M; Zonari, D1
Banerjee, UC; Chakraborti, AK; Dave, K; Dubey, S; Garg, SK; Goyal, R; Kumar, R; Meena, VS; Purohit, P; Saha, N; Seth, K; Sharma, SS1
Dallob, A; De Lepeleire, I; De Schepper, P; Ehrich, EW; Gertz, BJ; Mehlisch, DR; Porras, A; Riendeau, D; Seibold, JR; Van Hecken, A; Wittreich, J; Yuan, W1
Antes, L; Catella-Lawson, F; FitzGerald, GA; Gertz, BJ; Kapoor, S; Kujubu, D; Lasseter, KC; McAdam, B; Morrison, BW; Quan, H1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Sliwowski, Z; Stachura, J1
Brater, DC; Buechel, KL; Dilzer, SC; Ebel, DL; Gertz, BJ; Gumbs, CP; Lambrecht, LJ; Larson, PJ; Lasseter, KC; Musliner, TA; Obrda, O; Pinto, MB; Quan, H; Rudy, DW; Ryan, CF; Schwartz, JI; Sundblad, KJ; Swan, SK; Yao, SL1
Bjarnason, I; Bolognese, J; Crane, R; Hoover, M; Quan, H; Sigthorsson, G; Simon, T1
Chen, BH1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Nakamura, T; Pajdo, R; Pawlik, M; Ptak, A; Schuppan, D1
Gretzer, B; Maricic, N; Peskar, BM; Respondek, M; Schuligoi, R1
Bielański, W; Bonior, J; Jachimczak, B; Jaworek, J; Konturek, PC; Konturek, SJ; Kot, M; Pawlik, WW; Sendur, R; Stachura, J; Tomaszewska, R1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Pajdo, R; Ptak, A; Sliwowski, Z1
Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecien, S; Pajdo, R; Pawlik, M; Ptak, A; Sliwowski, Z1
Browning, RA; Burgess, FW1
Babaev, VR; Burleigh, ME; Fazio, S; Gautam, S; Harris, RC; Linton, MF; Marnett, LJ; Morrow, JD; Oates, JA; Riendeau, D1
Araki, H; Hase, S; Komoike, Y; Takeuchi, K; Tanaka, A1
Bakalova, R; Kanno, I; Matsuura, T1
Peres, MF; Silberstein, SD1
Abdel-Salam, OM; Arbid, MS; Baiuomy, AR; El-Batran, S; El-Shenawy, SM1
Benchaib, M; Doret, M; Gharib, C; Mellier, G; Pasquier, JC; Piacenza, JM1
Aoi, M; Kagawa, S; Kawauchi, S; Mimaki, H; Takeuchi, K1
Arakawa, T; Kanatsu, K; Kato, S; Ogawa, Y; Okayama, M; Takeuchi, K; Watanabe, T1
Bakhle, YS; Chaves, CT; Ferreira-Alves, DL; Francischi, JN; Lima, AS; Moura, AC; Rocha, OA1
Araki, H; Komoike, Y; Matsumoto, M; Takeuchi, K; Tanaka, A1
Clausen, C; Gires, O; Hölzel, D; Kastenbauer, E; Lang, S; Lauffer, L; Löhr, I; Schmitt, B; Wollenberg, B; Zeidler, R1
Calixto, JB; Pinheiro, RM1
Lisotto, C; Maggioni, F; Mainardi, F; Zanchin, G1
Barbosa, AM; Cogo, JC; do Amaral, RO; Hyslop, S; Teixeira, CF1
Hayashi, Y; Matsumoto, M; Miyazawa, T; Takeuchi, K1
Abdel-Salam, OM; Arbid, MS; Baiuomy, AR1
Blumenthal, M; Chen, TC; Kardosh, A; Schönthal, AH; Wang, WJ1
Aandahl, EM; Areklett, MA; Aukrust, P; Bryn, T; Frøland, SS; Johansson, CC; Taskén, K1
Agostinho, CL; Buchpiguel, CA; Damião, AO; Garcez, AT; Laudanna, AA; Leite, AZ; Lopasso, FP; Lordello, ML; Sipahi, AM1
Hayashi, Y; Murakami, M; Takeeda, M; Takeuchi, K; Yamato, M1
Ebata, M; Kanatani, K; Murakami, M; Okabe, S1
Siow, HC1
Hayashi, Y; Kubo, Y; Takeuchi, K; Tanaka, A1
Diament, MJ; Klein, SM; Peluffo, GD; Rodríguez, VA; Stillitani, I1
Fujimura, MD; Koch, VH; Vaisbich, MH1
Hosaka, EM; Santos, OF; Seguro, AC; Vattimo, MF1
Brzozowski, T; Drozdowicz, D; Konturek, PC; Konturek, SJ; Kwiecien, S; Pajdo, R; Pawlik, M; Pawlik, WW; Sliwowski, Z1
Câmara, NO; Cenedeze, MA; Feitoza, CQ; Gonçalves, GM; Pacheco-Silva, A; Pinheiro, HS; Santos, OF1
Chang, CC; Chen, SH; Fang, CL; Hsieh, CR; Lien, GS; Lou, HY; Pan, S1
Lucas, R; Mitchell, JA; Vojnovic, I; Warner, TD1
Lacomblez, L1
Imamura, S; Momma, K; Takami, T1
Armstrong, PJ; Carey, DJ; Elmore, JR; Franklin, DP1
Takahira, Y; Takeuchi, K; Tanaka, A; Taniguchi, M; Yokota, A1
Babaev, VR; Burleigh, ME; Fazio, S; Linton, MF; Major, AS; McCaleb, JL; Morrow, JD; Oates, JA; Yancey, PG1
Carl-McGrath, S; Chen, J; Ebert, MP; Gu, P; Hoffmann, J; Kubisch, C; Malfertheiner, P; Röcken, C; Schäfer, C; Treiber, G1
Takeuchi, K; Tanaka, A; Taniguchi, M; Yokota, A1
Chau, FL; Cho, CH; Guo, JS; Koo, MW1
Bishop-Bailey, D; Mitchell, JA; Vojnovic, I; Warner, TD1
Klaus, G; Kömhoff, M; Nazarowa, S; Reinalter, SC; Seyberth, HW1
Jarnagin, K; Kolaja, K; Pearson, CI; Sagartz, J; Tugendreich, S1
Takahira, Y; Takeuchi, K; Tanaka, A; Yokota, A1
de Francischi, JN; de Menezes, GB; dos Reis, WG; Duarte, ID; Santos, JM1
Bishnoi, M; Kulkarni, SK; Kumar, A; Patil, CS1
Gutierrez, JM; Olivo, Rdo A; Teixeira, CF; Wallace, JL; Zamuner, SR1
Macedo, GM; Medeiros, BA; Nobre-e-Souza, MA; Palheta-Junior, RC; Santos, AA; Santos, CL; Souza, MH; Troncon, LE1
Hudson, M; Pilote, L; Rahme, E; Richard, H1
Rijnberg, WJ; Schreurs, BW; van der Heide, HJ; Van Kampen, A; Van Sorge, A1
Grohs, JG; Schmidt, M; Wanivenhaus, A1
Aihara, E; Amagase, K; Kato, S; Takeuchi, K; Tanaka, A1
Boursinos, L; Karachalios, T; Khaldi, L; Malizos, KN; Poultsides, L1
Aihara, E; Nakashima, M; Nishio, H; Takeuchi, K; Terashima, S1
Kazi, JU; Li, H; Soh, JW; Thompson, WJ; Weinstein, IB1
de Zeeuw, D; Navis, G; Vogt, L; Woittiez, AJ1
de Godoy, MA; Rattan, N; Rattan, S1
Dai, G; Fischer, JW; Fries, S; Grosser, T; Lindner, V; Marzoll, A; Nagy, N; Wördehoff, L1
Murakami, M; Nakagiri, A1
Amagase, K; Kato, S; Satoh, H; Takeuchi, K; Tanaka, A1
Bekkelund, SI; Müller, KI2
de Borst, MH; de Cuba, MM; Doorenbos, CR; Gans, RO; Kema, IP; Navis, G; van den Born, J; Vogt, L1
Alizzi, AM; Bidstrup, BP; Boon, VH; Diqer, AM; Leslie, BJ; Steele, M; Summers, P; Tantiongco, JP; Thompson, T; Williams, D1
Bühler, MI; Ortiz, ME; Zelarayán, LI1
Jansson, L; Sandberg, M1
Matteson, EL; Thongprayoon, C; Ungprasert, P1
Brzozowski, T; Czekaj, R; Kwiecien, S; Magierowska, K; Magierowski, M; Majka, J; Pajdo, R; Ptak-Belowska, A; Sliwowski, Z; Surmiak, M1
Arfè, A; Castellsague, J; Garbe, E; Herings, R; Kollhorst, B; Lucchi, S; Masclee, GMC; Perez-Gutthann, S; Romio, S; Schade, R; Schink, T; Schuemie, MJ; Scotti, L; Straatman, H; Sturkenboom, MCJM; Valkhoff, VE; Varas-Lorenzo, C; Villa, M1

Reviews

2 review(s) available for rofecoxib and indomethacin

ArticleYear
Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.
    Clinica chimica acta; international journal of clinical chemistry, 2010, Apr-02, Volume: 411, Issue:7-8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Humans; Indomethacin; Intestine, Small; Lactones; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfones

2010
Nonaspirin Nonsteroidal Anti-Inflammatory Drugs and Risk of Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Observational Studies.
    Stroke, 2016, Volume: 47, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cerebral Hemorrhage; Diclofenac; Humans; Ibuprofen; Incidence; Indomethacin; Lactones; Meloxicam; Naproxen; Observational Studies as Topic; Odds Ratio; Piroxicam; Proportional Hazards Models; Stroke; Sulfones; Thiazines; Thiazoles

2016

Trials

8 trial(s) available for rofecoxib and indomethacin

ArticleYear
Characterization of rofecoxib as a cyclooxygenase-2 isoform inhibitor and demonstration of analgesia in the dental pain model.
    Clinical pharmacology and therapeutics, 1999, Volume: 65, Issue:3

    Topics: Adult; Analgesics, Non-Narcotic; Animals; CHO Cells; Cricetinae; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Female; Humans; Ibuprofen; Indomethacin; Isoenzymes; Lactones; Male; Models, Biological; Pain; Prostaglandin-Endoperoxide Synthases; Sulfones; Tooth

1999
Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids.
    The Journal of pharmacology and experimental therapeutics, 1999, Volume: 289, Issue:2

    Topics: 6-Ketoprostaglandin F1 alpha; Aged; Aged, 80 and over; Blood Platelets; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Eicosanoids; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Sodium; Sulfones; Thromboxane B2; Water-Electrolyte Balance

1999
Effect of cyclooxygenase-2 inhibition on renal function in elderly persons receiving a low-salt diet. A randomized, controlled trial.
    Annals of internal medicine, 2000, Jul-04, Volume: 133, Issue:1

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Creatinine; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diet, Sodium-Restricted; Double-Blind Method; Female; Glomerular Filtration Rate; Humans; Indomethacin; Isoenzymes; Kidney; Lactones; Male; Membrane Proteins; Potassium; Prostaglandin-Endoperoxide Synthases; Single-Blind Method; Sodium; Sulfones

2000
COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects: a double blind crossover study comparing rofecoxib with placebo and indomethacin.
    Gut, 2000, Volume: 47, Issue:4

    Topics: Adolescent; Adult; Chromium Radioisotopes; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Double-Blind Method; Edetic Acid; Female; Humans; Indomethacin; Intestinal Mucosa; Isoenzymes; Lactones; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Sulfones

2000
Treatment with type-2 selective and non-selective cyclooxygenase inhibitors improves T-cell proliferation in HIV-infected patients on highly active antiretroviral therapy.
    AIDS (London, England), 2004, Apr-09, Volume: 18, Issue:6

    Topics: Adult; Antiretroviral Therapy, Highly Active; Cell Division; Cyclooxygenase Inhibitors; Female; HIV Infections; Humans; Indomethacin; Lactones; Lymphocyte Count; Male; Middle Aged; Sulfones; T-Lymphocytes; Viral Load

2004
Similar effects of rofecoxib and indomethacin on the incidence of heterotopic ossification after hip arthroplasty.
    Acta orthopaedica, 2007, Volume: 78, Issue:1

    Topics: Adolescent; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Humans; Indomethacin; Lactones; Middle Aged; Ossification, Heterotopic; Sulfones; Tablets

2007
Selective COX-2 inhibitor versus indomethacin for the prevention of heterotopic ossification after hip replacement: a double-blind randomized trial of 100 patients with 1-year follow-up.
    Acta orthopaedica, 2007, Volume: 78, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthroplasty, Replacement, Hip; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Female; Follow-Up Studies; Humans; Indomethacin; Lactones; Male; Middle Aged; Ossification, Heterotopic; Sulfones

2007
Selective cyclooxygenase-2 (COX-2) inhibition reduces proteinuria in renal patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2009, Volume: 24, Issue:4

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Female; Humans; Indomethacin; Kidney; Kidney Diseases; Lactones; Lisinopril; Male; Middle Aged; Proteinuria; Sulfones

2009

Other Studies

103 other study(ies) available for rofecoxib and indomethacin

ArticleYear
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
    Bioorganic & medicinal chemistry letters, 1999, Jul-05, Volume: 9, Issue:13

    Topics: Administration, Oral; Animals; Biological Availability; CHO Cells; Cricetinae; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Sulfones

1999
SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.
    Bioorganic & medicinal chemistry letters, 1999, Aug-02, Volume: 9, Issue:15

    Topics: Administration, Oral; Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Macaca mulatta; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Saimiri; Structure-Activity Relationship; U937 Cells

1999
A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 1999, Nov-15, Volume: 9, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Furans; Isoenzymes; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship

1999
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 1999, Nov-15, Volume: 9, Issue:22

    Topics: Animals; Biological Availability; CHO Cells; Cricetinae; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Furans; Humans; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyridines; Rats

1999
2,2-Dimethyl-4,5-diaryl-3(2H)furanone derivatives as selective cyclo-oxygenase-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2001, Jan-22, Volume: 11, Issue:2

    Topics: Animals; Arthritis, Experimental; Combinatorial Chemistry Techniques; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Edema; Foot Diseases; Furans; Inhibitory Concentration 50; Isoenzymes; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2001
Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors.
    Bioorganic & medicinal chemistry letters, 2001, Oct-22, Volume: 11, Issue:20

    Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Inflammation; Isoenzymes; Naphthalenes; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship

2001
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
    Journal of medicinal chemistry, 2002, Mar-28, Volume: 45, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Blood Platelets; Celecoxib; Crystallography, X-Ray; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lactones; Membrane Proteins; Models, Chemical; Models, Molecular; Monocytes; Prostaglandin-Endoperoxide Synthases; Protein Binding; Protein Conformation; Pyrazoles; Sulfonamides; Sulfones

2002
4-(4-cycloalkyl/aryl-oxazol-5-yl)benzenesulfonamides as selective cyclooxygenase-2 inhibitors: enhancement of the selectivity by introduction of a fluorine atom and identification of a potent, highly selective, and orally active COX-2 inhibitor JTE-522(1)
    Journal of medicinal chemistry, 2002, Mar-28, Volume: 45, Issue:7

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Benzenesulfonates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Fluorine; Humans; Inhibitory Concentration 50; Isoenzymes; Membrane Proteins; Models, Chemical; Oxazoles; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Temperature

2002
Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile.
    Bioorganic & medicinal chemistry letters, 2002, Nov-18, Volume: 12, Issue:22

    Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Lactones; Membrane Proteins; Pharmacokinetics; Prostaglandin-Endoperoxide Synthases; Rats; Structure-Activity Relationship; Sulfones

2002
Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.
    Journal of natural products, 2002, Volume: 65, Issue:11

    Topics: Acrolein; Alkaloids; Animals; Anthraquinones; Aspirin; Biological Assay; Catalysis; Cinnamomum zeylanicum; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Eugenol; Flavonoids; Indomethacin; Inhibitory Concentration 50; Isoenzymes; Kinetics; Lactones; Models, Molecular; Nitrobenzenes; Oleanolic Acid; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases; Pyrogallol; Steroids; Sulfonamides; Sulfones; Syzygium; Terpenes; Triterpenes; Ursolic Acid

2002
The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Aug-05, Volume: 100, Issue:16

    Topics: Adenosine Triphosphate; Alprostadil; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Transport; Cell Line; Cell Membrane; Diffusion; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Humans; Insecta; Multidrug Resistance-Associated Proteins; Prostaglandins; Prostaglandins A; Prostaglandins F; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Thromboxane B2; Time Factors

2003
Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
    Journal of medicinal chemistry, 2003, Jul-31, Volume: 46, Issue:16

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Binding Sites; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Imidazoles; Inflammation; Isoenzymes; Male; Membrane Proteins; Models, Molecular; Pain Measurement; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides

2003
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.
    Journal of medicinal chemistry, 2003, Sep-11, Volume: 46, Issue:19

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzenesulfonamides; Binding Sites; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Humans; Inhibitory Concentration 50; Isoenzymes; Male; Membrane Proteins; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sheep; Sodium; Spodoptera; Structure-Activity Relationship; Sulfonamides

2003
In vitro structure-activity relationship and in vivo studies for a novel class of cyclooxygenase-2 inhibitors: 5-aryl-2,2-dialkyl-4-phenyl-3(2H)furanone derivatives.
    Journal of medicinal chemistry, 2004, Feb-12, Volume: 47, Issue:4

    Topics: Adult; Animals; Arthritis, Experimental; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Edema; Furans; Humans; In Vitro Techniques; Isoenzymes; Macrophages, Peritoneal; Male; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Structure-Activity Relationship

2004
Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.
    Bioorganic & medicinal chemistry letters, 2004, Mar-08, Volume: 14, Issue:5

    Topics: Alcohols; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Humans; Isoenzymes; Membrane Proteins; Phenylpropionates; Prostaglandin-Endoperoxide Synthases

2004
1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors.
    Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9

    Topics: Acetates; Animals; Binding Sites; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Esters; Membrane Proteins; Mice; Models, Molecular; Prostaglandin-Endoperoxide Synthases; Pyrroles

2005
Expanding the ChemGPS chemical space with natural products.
    Journal of natural products, 2005, Volume: 68, Issue:7

    Topics: Biological Products; Combinatorial Chemistry Techniques; Computer Graphics; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship

2005
Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.
    Journal of natural products, 2007, Volume: 70, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Fruit; Lignans; Lipoxygenase Inhibitors; Molecular Structure; Morinda; Plants, Medicinal; Polynesia

2007
1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities.
    Bioorganic & medicinal chemistry letters, 2008, Jan-01, Volume: 18, Issue:1

    Topics: 4-Butyrolactone; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Screening Assays, Antitumor; Humans; Indoles; Models, Molecular; Tosyl Compounds

2008
Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors.
    Bioorganic & medicinal chemistry letters, 2009, Jan-15, Volume: 19, Issue:2

    Topics: Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Hydrogen Bonding; Models, Molecular; Thiones

2009
Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

    Topics: Binding Sites; Computer Simulation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Inhibitory Concentration 50; Oxazoles; Protein Binding; Structure-Activity Relationship

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors.
    Bioorganic & medicinal chemistry, 2010, Sep-01, Volume: 18, Issue:17

    Topics: Binding Sites; Cyclooxygenase 2 Inhibitors; Drug Design; Heterocyclic Compounds; Humans; Models, Molecular; Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Synthesis and structure-activity relationship studies of urea-containing pyrazoles as dual inhibitors of cyclooxygenase-2 and soluble epoxide hydrolase.
    Journal of medicinal chemistry, 2011, Apr-28, Volume: 54, Issue:8

    Topics: Animals; Cyclooxygenase 2; Enzyme Inhibitors; Epoxide Hydrolases; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Pyrazoles; Rats; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Urea

2011
Bioactive sulfoximines: syntheses and properties of Vioxx analogs.
    Bioorganic & medicinal chemistry letters, 2011, Aug-15, Volume: 21, Issue:16

    Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; HEK293 Cells; Humans; Lactones; Methionine Sulfoximine; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Sulfones

2011
Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.
    Journal of medicinal chemistry, 2012, Mar-08, Volume: 55, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Drug Screening Assays, Antitumor; Female; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Sheep; Stereoisomerism; Structure-Activity Relationship; Sulindac

2012
Synthesis, evaluation and docking studies on 3-alkoxy-4-methanesulfonamido acetophenone derivatives as non ulcerogenic anti-inflammatory agents.
    European journal of medicinal chemistry, 2012, Volume: 49

    Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Edema; Models, Molecular; Protein Binding; Rats; Rats, Wistar; Stomach Ulcer; Sulfonamides

2012
Syntheses and biological activities of sulfoximine-based acyclic triaryl olefins.
    Bioorganic & medicinal chemistry letters, 2012, Jul-01, Volume: 22, Issue:13

    Topics: Alkenes; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Imines; Protein Binding; Sulfones

2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Synthesis of methanesulphonamido-benzimidazole derivatives as gastro-sparing antiinflammatory agents with antioxidant effect.
    Bioorganic & medicinal chemistry letters, 2017, 07-01, Volume: 27, Issue:13

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Benzimidazoles; Carrageenan; Dose-Response Relationship, Drug; Edema; Molecular Structure; Rats; Stomach Ulcer; Structure-Activity Relationship; Sulfonamides

2017
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.
    European journal of medicinal chemistry, 2017, Oct-20, Volume: 139

    Topics: 3-Hydroxysteroid Dehydrogenases; Aldo-Keto Reductase Family 1 Member C3; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxyprostaglandin Dehydrogenases; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Triazoles; Tumor Cells, Cultured

2017
Cyclic enaminone as new chemotype for selective cyclooxygenase-2 inhibitory, anti-inflammatory, and analgesic activities.
    European journal of medicinal chemistry, 2019, Nov-15, Volume: 182

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Edema; Heterocyclic Compounds; Humans; Male; Molecular Docking Simulation; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2019
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
    European journal of pharmacology, 1999, Nov-26, Volume: 385, Issue:1

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Gastric Mucosa; Gastrins; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Regional Blood Flow; Reperfusion Injury; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Time Factors

1999
COX-2 inhibitors and renal function in elderly people.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2000, Sep-05, Volume: 163, Issue:5

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diet, Sodium-Restricted; Double-Blind Method; Glomerular Filtration Rate; Humans; Indomethacin; Lactones; Randomized Controlled Trials as Topic; Sulfones

2000
Involvement of cyclooxygenase (COX)-2 products in acceleration of ulcer healing by gastrin and hepatocyte growth factor.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2000, Volume: 51, Issue:4 Pt 1

    Topics: Animals; Antibodies; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Gastrins; Hepatocyte Growth Factor; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; Nitrobenzenes; Peptic Ulcer; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Sulfones

2000
Effects of specific inhibition of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the rat stomach with normal mucosa and after acid challenge.
    British journal of pharmacology, 2001, Volume: 132, Issue:7

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Furans; Gastric Mucosa; Gene Expression Regulation, Enzymologic; Hydrochloric Acid; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; RNA, Messenger; Stomach; Sulfones

2001
Involvement of cyclooxygenase-derived prostaglandin E2 and nitric oxide in the protection of rat pancreas afforded by low dose of lipopolysaccharide.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2001, Volume: 52, Issue:1

    Topics: Acute Disease; Amylases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ceruletide; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Indomethacin; Isoenzymes; Lactones; Lipopolysaccharides; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nitrobenzenes; Organ Size; Pancreas; Pancreatitis; Penicillamine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Resveratrol; S-Nitroso-N-Acetylpenicillamine; Stilbenes; Sulfonamides; Sulfones

2001
Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers.
    Microscopy research and technique, 2001, Jun-01, Volume: 53, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Chronic Disease; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Gastrins; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Male; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Radioimmunoassay; Rats; Rats, Wistar; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha

2001
Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves.
    European journal of pharmacology, 2001, Sep-21, Volume: 427, Issue:3

    Topics: Adenosine; Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Denervation; Digestive System; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Gene Expression Regulation, Enzymologic; Indomethacin; Ischemic Preconditioning; Isoenzymes; Lactones; Male; Membrane Proteins; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Regional Blood Flow; Reperfusion Injury; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Sulfones; Theophylline; Time Factors

2001
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
    Medicine and health, Rhode Island, 2001, Volume: 84, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac; Etodolac; Humans; Ibuprofen; Indomethacin; Ketorolac; Lactones; Nabumetone; Naproxen; Pain, Postoperative; Piroxicam; Pyrazoles; Sulfonamides; Sulfones; Time Factors

2001
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice.
    Circulation, 2002, Apr-16, Volume: 105, Issue:15

    Topics: Animals; Arteriosclerosis; Blood Platelets; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Indomethacin; Isoenzymes; Kinetics; Lactones; Lipids; Liver Transplantation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Receptors, LDL; RNA, Messenger; Sulfones; Thromboxane B2

2002
Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16 Suppl 2

    Topics: Amino Acid Sequence; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastrointestinal Hemorrhage; Gastrointestinal Motility; Gene Expression; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; Molecular Sequence Data; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stomach Ulcer; Sulfones; Up-Regulation

2002
The cyclooxygenase inhibitors indomethacin and Rofecoxib reduce regional cerebral blood flow evoked by somatosensory stimulation in rats.
    Experimental biology and medicine (Maywood, N.J.), 2002, Volume: 227, Issue:7

    Topics: Animals; Blood Flow Velocity; Cerebrovascular Circulation; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Electric Stimulation; Evoked Potentials, Somatosensory; Heart Rate; Hindlimb; Indomethacin; Isoenzymes; Lactones; Laser-Doppler Flowmetry; Male; Membrane Proteins; Neurons; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Somatosensory Cortex; Sulfones

2002
Hemicrania continua responds to cyclooxygenase-2 inhibitors.
    Headache, 2002, Volume: 42, Issue:6

    Topics: Celecoxib; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Lactones; Male; Migraine Disorders; Pyrazoles; Recurrence; Sulfonamides; Sulfones

2002
Studies on the anti-inflammatory and anti-nociceptive effects of melatonin in the rat.
    Pharmacological research, 2002, Volume: 46, Issue:3

    Topics: Administration, Topical; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase Inhibitors; Cysteamine; Edema; Hindlimb; Indomethacin; Inflammation; Injections, Intraperitoneal; Lactones; Male; Melatonin; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Sulfones; Tail

2002
In vitro study of tocolytic effect of rofecoxib, a specific cyclo-oxygenase 2 inhibitor. Comparison and combination with other tocolytic agents.
    BJOG : an international journal of obstetrics and gynaecology, 2002, Volume: 109, Issue:9

    Topics: Analysis of Variance; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Indomethacin; Isoenzymes; Lactones; Membrane Proteins; Myometrium; Nicardipine; Pregnancy; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Ritodrine; Sulfones; Tocolytic Agents; Uterine Contraction; Vasotocin

2002
COX and NOS isoforms involved in acid-induced duodenal bicarbonate secretion in rats.
    Digestive diseases and sciences, 2002, Volume: 47, Issue:9

    Topics: Animals; Bicarbonates; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Duodenum; Guanidines; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfones

2002
Ulcerogenic influence of selective cyclooxygenase-2 inhibitors in the rat stomach with adjuvant-induced arthritis.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:2

    Topics: Animals; Arthritis, Experimental; Capillary Permeability; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Mucosa; Immunohistochemistry; Indomethacin; Isoenzymes; Lactones; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Stomach Ulcer; Sulfonamides; Sulfones

2002
Selective inhibitors of cyclo-oxygenase-2 (COX-2) induce hypoalgesia in a rat paw model of inflammation.
    British journal of pharmacology, 2002, Volume: 137, Issue:6

    Topics: Animals; Carrageenan; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Edema; Hindlimb; Hyperalgesia; Indomethacin; Inflammation; Isoenzymes; Lactones; Male; Pain Threshold; Piroxicam; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Sulfonamides; Sulfones

2002
Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in rats.
    Digestion, 2002, Volume: 66, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Duodenal Ulcer; Enzyme Inhibitors; Guanidines; Indomethacin; Lactones; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Sulfones; Wound Healing

2002
Impaired monocyte function in cancer patients: restoration with a cyclooxygenase-2 inhibitor.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carcinoma, Squamous Cell; Cell Movement; Cyclooxygenase Inhibitors; Head and Neck Neoplasms; Indomethacin; Lactones; Monocytes; Prostaglandin-Endoperoxide Synthases; Receptors, CCR5; Sulfones

2003
Effect of the selective COX-2 inhibitors, celecoxib and rofecoxib in rat acute models of inflammation.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Edema; Indomethacin; Inflammation; Interleukin-1; Isoenzymes; Lactones; Male; Nitric Oxide; Peroxidase; Pleurisy; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Sulfones; Thromboxane B2; Tumor Necrosis Factor-alpha

2002
Rofecoxib for the treatment of chronic paroxysmal hemicrania.
    Cephalalgia : an international journal of headache, 2003, Volume: 23, Issue:4

    Topics: Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Lactones; Male; Recurrence; Sulfones; Vascular Headaches

2003
Pharmacological characterization of mouse hind paw oedema induced by Bothrops insularis (jararaca ilhoa) snake venom.
    Toxicon : official journal of the International Society on Toxinology, 2003, Volume: 42, Issue:5

    Topics: Animals; Antivenins; Blood Proteins; Bothrops; Crotalid Venoms; Cyclooxygenase Inhibitors; Cyproheptadine; Dexamethasone; Edema; Enzyme Inhibitors; Hindlimb; Histamine H1 Antagonists; Indomethacin; Lactones; Male; NG-Nitroarginine Methyl Ester; Pyrilamine; Serotonin Antagonists; Sulfones; Time Factors

2003
Both selective COX-1 and COX-2 inhibitors aggravate gastric damage induced in rats by 2-deoxy-D-glucose. relation to gastric hypermotility and COX-2 expression.
    Digestion, 2003, Volume: 68, Issue:2-3

    Topics: Animals; Cyclooxygenase Inhibitors; Deoxyglucose; Disease Models, Animal; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Gastrointestinal Motility; Indomethacin; Isoenzymes; Lactones; Male; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfones

2003
Studies on the anti-inflammatory effect of fluoxetine in the rat.
    Pharmacological research, 2004, Volume: 49, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Carrageenan; Celecoxib; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Edema; Fluoxetine; Foot; Imipramine; Indomethacin; Inflammation; Lactones; Melatonin; Pyrazoles; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Sulfonamides; Sulfones; Time Factors; Trazodone

2004
Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines.
    Cancer biology & therapy, 2004, Volume: 3, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Cycle; Cell Division; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Glioblastoma; Humans; Indomethacin; Isoenzymes; Isoxazoles; Lactones; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Sulfones; Sulindac

2004
Effect of a selective nonsteroidal anti-inflammatory inhibitor of cyclooxygenase-2 on the small bowel of rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2004, Volume: 37, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Indomethacin; Intestinal Mucosa; Intestine, Small; Isoenzymes; Lactones; Male; Permeability; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfones

2004
Roles of endogenous prostaglandins and cyclooxygenase izoenzymes in mucosal defense of inflamed rat stomach.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004, Volume: 55, Issue:1 Pt 2

    Topics: Administration, Oral; Animals; Body Weight; Capsaicin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastric Acid; Gastric Mucosa; Gastritis; Gene Expression; Indomethacin; Injections, Subcutaneous; Iodoacetamide; Isoenzymes; Lactones; Male; Membrane Proteins; Neurons, Afferent; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Rats, Wistar; Stomach Ulcer; Sulfones; Vagotomy

2004
Effects of indomethacin and rofecoxib on gastric mucosal damage in normal and Helicobacter pylori-infected mongolian gerbils.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2004, Volume: 55, Issue:1 Pt 2

    Topics: Administration, Oral; Animals; Dinoprostone; Drug Administration Schedule; Drug Synergism; Gastric Acid; Gastric Mucosa; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Histamine; Indomethacin; Injections, Subcutaneous; Lactones; Male; Peroxidase; Peroxidases; Stomach Ulcer; Sulfones; Time Factors

2004
Seasonal episodic paroxysmal hemicrania responding to cyclooxygenase-2 inhibitors.
    Cephalalgia : an international journal of headache, 2004, Volume: 24, Issue:5

    Topics: Aged; Chronic Disease; Cluster Headache; Creatinine; Cyclooxygenase Inhibitors; Female; Humans; Indomethacin; Lactones; Seasons; Sulfones

2004
Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility.
    Digestive diseases and sciences, 2004, Volume: 49, Issue:2

    Topics: Animals; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Gastrointestinal Hemorrhage; Gastrointestinal Motility; Indomethacin; Isoenzymes; Lactones; Male; Omeprazole; Peroxidase; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stomach; Stomach Ulcer; Sulfones

2004
Reduction of tumor progression and paraneoplastic syndrome development in murine lung adenocarcinoma by nonsteroidal antiinflammatory drugs.
    International journal of cancer, 2004, Jul-20, Volume: 110, Issue:6

    Topics: Adenocarcinoma; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Cell Survival; Chemotaxis; Cyclooxygenase Inhibitors; Cytokines; Disease Progression; Female; Indomethacin; Lactones; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Paraneoplastic Syndromes; Sulfones

2004
Bartter syndrome: benefits and side effects of long-term treatment.
    Pediatric nephrology (Berlin, Germany), 2004, Volume: 19, Issue:8

    Topics: Bartter Syndrome; Child; Child, Preschool; Cyclooxygenase Inhibitors; Female; Follow-Up Studies; Humans; Indomethacin; Infant; Lactones; Male; Potassium; Sulfones; Time Factors

2004
Effect of cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in rats.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2004, Volume: 37, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Biomarkers; Creatinine; Cyclooxygenase Inhibitors; Drug Combinations; Gentamicins; Glutathione Transferase; Indomethacin; Isoenzymes; Kidney; Lactones; Male; Rats; Rats, Wistar; Sulfones

2004
Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves.
    European journal of pharmacology, 2004, Sep-19, Volume: 499, Issue:1-2

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Denervation; Dinoprostone; Gastric Mucosa; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Ischemic Preconditioning; Isoenzymes; Lactones; Male; Membrane Proteins; Neurons, Afferent; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach; Sulfones; Tumor Necrosis Factor-alpha

2004
Cyclooxygenase 1 and/or 2 blockade ameliorates the renal tissue damage triggered by ischemia and reperfusion injury.
    International immunopharmacology, 2005, Volume: 5, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Enzymologic; Indomethacin; Ischemia; Kidney; Lactones; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Prostaglandin-Endoperoxide Synthases; Reperfusion Injury; RNA, Messenger; Sulfones

2005
Eradication of Helicobacter pylori significantly reduced gastric damage in nonsteroidal anti-inflammatory drug-treated Mongolian gerbils.
    World journal of gastroenterology, 2005, Jan-07, Volume: 11, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Chronic Disease; Dinoprostone; Gastritis; Gerbillinae; Helicobacter Infections; Helicobacter pylori; Indomethacin; Lactones; Male; Organ Size; Peroxidase; Stomach; Stomach Ulcer; Sulfones

2005
Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:6

    Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cell Line; Cyclooxygenase Inhibitors; Diclofenac; Enzyme Activation; Humans; Ibuprofen; Indomethacin; Lactones; Lung; Naproxen; Oxidation-Reduction; Prostaglandin-Endoperoxide Synthases; Protein Biosynthesis; Sulfones; tert-Butylhydroperoxide; Transcription, Genetic

2005
[Inflammation, nonsteroidal anti-inflammatory drugs and Alzheimer disease].
    Psychologie & neuropsychiatrie du vieillissement, 2004, Volume: 2, Issue:4

    Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Cyclooxygenase Inhibitors; Diclofenac; Humans; Indomethacin; Inflammation; Inflammation Mediators; Lactones; Risk Factors; Sulfones

2004
Increased constriction of the ductus arteriosus by dexamethasone, indomethacin, and rofecoxib in fetal rats.
    Circulation journal : official journal of the Japanese Circulation Society, 2005, Volume: 69, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Drug Evaluation, Preclinical; Drug Therapy, Combination; Ductus Arteriosus; Ductus Arteriosus, Patent; Fetus; Indomethacin; Lactones; Models, Animal; Rats; Rats, Wistar; Sulfones; Vasoconstriction

2005
Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors.
    Annals of vascular surgery, 2005, Volume: 19, Issue:2

    Topics: Amidines; Animals; Aortic Aneurysm, Abdominal; Benzylamines; Blotting, Western; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Indomethacin; Lactones; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Sulfones

2005
Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats.
    The Journal of pharmacology and experimental therapeutics, 2005, Volume: 314, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Colony Count, Microbial; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Enterobacteriaceae; Gastric Mucosa; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Lactones; Male; Membrane Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Ulcer; Sulfones

2005
Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice.
    Journal of molecular and cellular cardiology, 2005, Volume: 39, Issue:3

    Topics: Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Cells, Cultured; Chemokine CCL2; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Immunohistochemistry; Indomethacin; Lactones; Lipopolysaccharides; Liver Transplantation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Sulfonamides; Sulfones; Transplantation, Heterologous; Tumor Necrosis Factor-alpha

2005
Protective role of heat shock protein 27 in gastric mucosal injury.
    The Journal of pathology, 2005, Volume: 207, Issue:2

    Topics: Aged; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cyclooxygenase 1; Cyclooxygenase 2; Drug Therapy, Combination; Epithelial Cells; Female; Gastric Mucosa; Heat-Shock Proteins; Helicobacter Infections; Helicobacter pylori; Humans; Immunohistochemistry; Indomethacin; Injections, Intraperitoneal; Lactones; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Prospective Studies; Prostaglandin-Endoperoxide Synthases; Stomach Ulcer; Sulfones

2005
Development of intestinal, but not gastric damage caused by a low dose of indomethacin in the presence of rofecoxib.
    Inflammopharmacology, 2005, Volume: 13, Issue:1-3

    Topics: Ampicillin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Atropine; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Motility; Gene Expression; Guanidines; Indomethacin; Intestinal Mucosa; Intestine, Small; Lactones; Male; Pyrazoles; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stomach; Sulfones

2005
Worsening effect of partial sleep deprivation on indomethacin-induced gastric mucosal damage.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 82, Issue:3

    Topics: Animals; Base Sequence; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; DNA Primers; Gastric Mucosa; Indomethacin; Lactones; Male; Misoprostol; Prostaglandins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sleep Deprivation; Sulfones

2005
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3

    Topics: Aspirin; Blood Platelets; Blood Proteins; Calcimycin; Calcium; Celecoxib; Cell Line; Cerebrospinal Fluid Proteins; Cyclooxygenase 1; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Humans; Indomethacin; Ionophores; Lactones; Meloxicam; Naproxen; Organ Specificity; Organic Chemicals; Protein Binding; Pyrazoles; Sodium Salicylate; Sulfonamides; Sulfones; Synovial Fluid; Thiazines; Thiazoles; Thromboxane A2

2006
Increased systolic blood pressure with rofecoxib in congenital furosemide-like salt loss.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2006, Volume: 21, Issue:7

    Topics: Adolescent; Adult; Blood Pressure; Child; Child, Preschool; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Furosemide; Humans; Indomethacin; Lactones; Male; Retrospective Studies; Sex Factors; Sulfones; Systole; Time Factors

2006
NSAID-induced acute phase response is due to increased intestinal permeability and characterized by early and consistent alterations in hepatic gene expression.
    Toxicologic pathology, 2006, Volume: 34, Issue:2

    Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokine CCL2; Chemokines, CXC; Cyclooxygenase 2 Inhibitors; Databases, Factual; Dose-Response Relationship, Drug; Gene Expression; Ibuprofen; Indomethacin; Intestinal Mucosa; Intestines; Lactones; Lipopolysaccharides; Liver; Male; Permeability; Rats; Rats, Sprague-Dawley; Sulfones; Time Factors

2006
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
    Digestive diseases and sciences, 2006, Volume: 51, Issue:7

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Disease Models, Animal; Enterobacteriaceae; Flurbiprofen; Gastrointestinal Motility; Indomethacin; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Lactones; Male; Naproxen; Nitric Oxide; Nitric Oxide Synthase Type II; Pyrazoles; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfones; Time Factors; Up-Regulation

2006
Inhibition of prostaglandin F(2alpha) by selective cyclooxygenase 2 inhibitors accounts for reduced rat leukocyte migration.
    Inflammation, 2005, Volume: 29, Issue:4-6

    Topics: Animals; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Female; Indomethacin; Injections, Intraperitoneal; Lactones; Lipopolysaccharides; Neutrophil Infiltration; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Sulfones; Time Factors

2005
Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice.
    Pharmacology, 2007, Volume: 79, Issue:1

    Topics: Administration, Oral; Animals; Antinematodal Agents; Brain; Catalase; Cyclooxygenase 2 Inhibitors; Drug Synergism; Drug Therapy, Combination; Epilepsy, Tonic-Clonic; Glutathione; Indomethacin; Injections, Intraperitoneal; Kainic Acid; Lactones; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred Strains; Nitric Oxide; Peroxidase; Sulfonamides; Sulfones; Triterpenes

2007
Role of cyclooxygenases in oedema-forming activity of bothropic venoms.
    Toxicon : official journal of the International Society on Toxinology, 2007, Volume: 49, Issue:5

    Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents; Blotting, Western; Bothrops; Crotalid Venoms; Cyclooxygenase 2 Inhibitors; Dexamethasone; Edema; Indomethacin; Lactones; Male; Mice; Prostaglandin-Endoperoxide Synthases; Snake Bites; Sulfones

2007
Cyclooxygenase-2 inhibition increases gastric tone and delays gastric emptying in rats.
    Neurogastroenterology and motility, 2007, Volume: 19, Issue:3

    Topics: Animals; Celecoxib; Cyclooxygenase 2 Inhibitors; Gastric Emptying; Gastric Mucosa; Indomethacin; Isoxazoles; Ketorolac; Lactones; Male; Muscle, Smooth; Pyrazoles; Rats; Rats, Wistar; Stomach; Sulfonamides; Sulfones

2007
Risk of congestive heart failure with nonsteroidal antiinflammatory drugs and selective Cyclooxygenase 2 inhibitors: a class effect?
    Arthritis and rheumatism, 2007, Apr-15, Volume: 57, Issue:3

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Celecoxib; Cyclooxygenase 2 Inhibitors; Female; Heart Failure; Humans; Indomethacin; Lactones; Logistic Models; Male; Odds Ratio; Patient Readmission; Pyrazoles; Risk Assessment; Sulfonamides; Sulfones

2007
Effect of (S)-4-(1-(5-chloro-2-(4-fluorophenyoxy)benzamido)ethyl) benzoic acid (CJ-42794), a selective antagonist of prostaglandin E receptor subtype 4, on ulcerogenic and healing responses in rat gastrointestinal mucosa.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:3

    Topics: Animals; Benzamides; Benzoates; Gastric Mucosa; Indomethacin; Intestinal Mucosa; Lactones; Peptic Ulcer; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Stomach Ulcer; Sulfones; Wound Healing

2007
The effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures. An experimental study in rabbits.
    The Journal of bone and joint surgery. British volume, 2007, Volume: 89, Issue:9

    Topics: Analysis of Variance; Animals; Bony Callus; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Fracture Healing; Fractures, Bone; Indomethacin; Lactones; Male; Meloxicam; Prednisolone; Rabbits; Sulfones; Thiazines; Thiazoles

2007
Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2007, Volume: 58, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bridged Bicyclo Compounds; Caproates; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gastric Acid; Gastric Acidity Determination; Gastric Mucosa; Hydrogen-Ion Concentration; Indomethacin; Lactones; Male; Membrane Potentials; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrazoles; Receptors, Epoprostenol; Receptors, Prostaglandin; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP3 Subtype; Stomach Diseases; Sulfones; Taurocholic Acid

2007
Celecoxib-induced growth inhibition in SW480 colon cancer cells is associated with activation of protein kinase G.
    Molecular carcinogenesis, 2008, Volume: 47, Issue:7

    Topics: Apoptosis; Celecoxib; Cell Adhesion Molecules; Cell Proliferation; Colonic Neoplasms; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclin D1; Cyclooxygenase Inhibitors; Enzyme Activation; Humans; Indomethacin; Lactones; Meclofenamic Acid; Microfilament Proteins; Mitogen-Activated Protein Kinase 8; Phosphoproteins; Phosphorylation; Pyrazoles; Sulfonamides; Sulfones; Tumor Cells, Cultured

2008
COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 296, Issue:2

    Topics: Anal Canal; Animals; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; Dose-Response Relationship, Drug; Indomethacin; Lactones; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle Contraction; Muscle, Smooth; Polymerase Chain Reaction; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane A2, Prostaglandin H2; RNA, Messenger; Sulfones

2009
Cyclooxygenase inhibitors repress vascular hyaluronan-synthesis in murine atherosclerosis and neointimal thickening.
    Journal of cellular and molecular medicine, 2009, Volume: 13, Issue:9B

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Carotid Arteries; Cyclooxygenase Inhibitors; Disease Models, Animal; Glucuronosyltransferase; Hyaluronan Synthases; Hyaluronic Acid; Indomethacin; Lactones; Male; Mice; Mice, Transgenic; Neointima; Protein Isoforms; Sulfones

2009
Roles of NADPH oxidase in occurrence of gastric damage and expression of cyclooxygenase-2 during ischemia/reperfusion in rat stomachs.
    Journal of pharmacological sciences, 2009, Volume: 111, Issue:4

    Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Gastric Mucosa; Hydrogen Peroxide; Indomethacin; Ischemia; Lactones; Male; NADPH Oxidases; Onium Compounds; Peroxidase; Pyrazoles; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sulfones; Up-Regulation

2009
Hemicrania continua changed to chronic paroxysmal hemicrania after treatment with cyclooxygenase-2 inhibitor.
    Headache, 2011, Volume: 51, Issue:2

    Topics: Cyclooxygenase 2 Inhibitors; Female; Headache; Humans; Indomethacin; Lactones; Middle Aged; Paroxysmal Hemicrania; Sulfones; Treatment Outcome

2011
[A woman with unilateral headache].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2011, Apr-08, Volume: 131, Issue:7

    Topics: Chronic Disease; Cyclooxygenase 2 Inhibitors; Delayed Diagnosis; Diagnosis, Differential; Disease Progression; Female; Headache; Humans; Indomethacin; Lactones; Middle Aged; Paroxysmal Hemicrania; Sulfones; Time Factors; Treatment Outcome

2011
Antiproteinuric treatment reduces urinary loss of vitamin D-binding protein but does not affect vitamin D status in patients with chronic kidney disease.
    The Journal of steroid biochemistry and molecular biology, 2012, Volume: 128, Issue:1-2

    Topics: Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Cyclooxygenase Inhibitors; Drug Therapy, Combination; Female; Humans; Hydroxycholecalciferols; Indomethacin; Kidney Failure, Chronic; Lactones; Lisinopril; Male; Middle Aged; Proteinuria; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Sulfones; Vitamin D Deficiency; Vitamin D-Binding Protein

2012
Reduction of post-surgical pericardial adhesions using a pig model.
    Heart, lung & circulation, 2012, Volume: 21, Issue:1

    Topics: Animals; Biological Availability; Biomarkers; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Drug Monitoring; Indomethacin; Inflammation; Lactones; Pericardium; Perioperative Period; Polyethylene Glycols; Postoperative Complications; Sternotomy; Sulfones; Surface-Active Agents; Swine; Thromboxane B2; Tissue Adhesions; Treatment Outcome

2012
Involvement of PLA2, COX and LOX in Rhinella arenarum oocyte maturation.
    Zygote (Cambridge, England), 2014, Volume: 22, Issue:4

    Topics: Animals; Arachidonic Acid; Bufo arenarum; Cells, Cultured; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Indomethacin; Lactones; Lipoxygenase; Masoprocol; Melitten; Oocytes; Oogenesis; Phospholipases A2; Progesterone; Prostaglandin-Endoperoxide Synthases; Quinacrine; Sulfones

2014
Effects of cyclooxygenase inhibition on insulin release and pancreatic islet blood flow in rats.
    Upsala journal of medical sciences, 2014, Volume: 119, Issue:4

    Topics: Animals; Blood Flow Velocity; Blood Glucose; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Duodenum; Glucose; Indomethacin; Insulin; Islets of Langerhans; Lactones; Male; Membrane Proteins; Piperazines; Pyrazoles; Rats; Rats, Wistar; Regional Blood Flow; Sulfones; Thiazoles

2014
Mechanisms of curcumin-induced gastroprotection against ethanol-induced gastric mucosal lesions.
    Journal of gastroenterology, 2018, Volume: 53, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Capsaicin; CDX2 Transcription Factor; Curcumin; Cyclooxygenase 2 Inhibitors; Denervation; Down-Regulation; Ethanol; Female; Gastric Mucosa; Gastrins; Gene Expression; Heme Oxygenase (Decyclizing); Hypoxia-Inducible Factor 1, alpha Subunit; Indomethacin; Lactones; Male; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Regional Blood Flow; RNA, Messenger; Stomach Diseases; Sulfones; Superoxide Dismutase; TRPV Cation Channels; Up-Regulation

2018
Risk of acute myocardial infarction during use of individual NSAIDs: A nested case-control study from the SOS project.
    PloS one, 2018, Volume: 13, Issue:11

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Case-Control Studies; Diclofenac; Etoricoxib; Female; Humans; Indomethacin; Ketorolac; Lactones; Male; Middle Aged; Myocardial Infarction; Odds Ratio; Risk Factors; Sulfones

2018