rocaglamide has been researched along with rocagloic-acid* in 1 studies
1 other study(ies) available for rocaglamide and rocagloic-acid
Article | Year |
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Potent cytotoxic rocaglamide derivatives from the fruits of Amoora cucullata.
Two new rocaglamide derivatives, 1-O-formylrocagloic acid (1) and 3'-hydroxy rocagloic acid (2), together with five known compounds, rocaglaol (3), rocagloic acid (4), 3'-hydroxymethylrocaglate (5), 1-O-formylmethyl rocaglate (6), and methylrocaglate (7), were isolated from the fruits of Amoora cucullata. Their structures were elucidated by spectroscopic methods. Compounds 1-3, 6, and 7 exhibited potent cytotoxicity against KB, BC, and NCI-H187 cell lines, whereas 4 and 5 showed selective cytotoxicity against NCI-H187 cell line. Topics: Benzofurans; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Magnetic Resonance Spectroscopy; Meliaceae; Molecular Conformation; Reference Standards; Seeds; Sensitivity and Specificity; Stereoisomerism; Structure-Activity Relationship | 2006 |