robinetin and fisetin

robinetin has been researched along with fisetin* in 2 studies

Other Studies

2 other study(ies) available for robinetin and fisetin

Article	Year
Fisetin and Robinetin antiradical activity under solvent effect: density functional theory study. Journal of molecular modeling, 2022, Aug-01, Volume: 28, Issue:8 The structural and antioxidant activity of two flavonols, namely, Fisetin and Robinetin, have been investigated employing the density functional theory (DFT) using B3LYP functional and 6-311++G (d, p) basis set. The calculations were performed in the gas phase and under the solvent effect of water, dimethylsulfoxide (DMSO), methanol, and benzene. The Hydrogen-Atom Transfer (HAT), single Electron Transfer Followed by Proton Transfer (SET-PT), and sequential Proton Loss Electron Transfer (SPLET) mechanisms were investigated to rationalize the radical scavenging capacities and to identify the favored antioxidant mechanism. Hence, the bond dissociation enthalpies (BDE) ionization potential (IP), IE, proton dissociation enthalpy (PDE), proton affinity (PA), and electron Transfer enthalpy (ETE) related to each mechanism were reported and discussed in function of the solvent effect. For both flavonols, the results showed that 4'-OH hydroxyl is the preferred active site following the trend 4'-OH > 3'-OH > 3-OH > (5'-OH) > 7-OH. Besides, the HAT mechanism is energetically the most favored pathway. The energetically favored solvents follow the trends water > DMSO > benzene > methanol and benzene > DMSO > methanol > water, for Fisetin and Robinetin, respectively. Topics: Antioxidants; Benzene; Density Functional Theory; Dimethyl Sulfoxide; Flavonoids; Flavonols; Hydrogen; Methanol; Protons; Solvents; Thermodynamics; Water	2022
Relationships between structures of hydroxyflavones and their antioxidative effects. Bioorganic & medicinal chemistry letters, 2010, Sep-15, Volume: 20, Issue:18 Even hydroxyflavones show diverse biological functions, they have two common features such as showing antioxidative effects and containing hydroxyl groups. The authors tested the antioxidative effects of thirty hydroxyflavones using 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. While the scavenging activity of galangin, 3,5,7-trihydroxyflavone was 52.5%, fisetin, 3,7,3',4'-tetrahydroxyflavone showed 85.2%. To investigate the relationships between the structures of hydroxyflavones and their antioxidative effects, the three-dimensional quantitative structure-activity relationships were examined. Topics: Antioxidants; Flavones; Flavonoids; Flavonols; Free Radical Scavengers; Models, Molecular; Quantitative Structure-Activity Relationship	2010

Article

Year

Fisetin and Robinetin antiradical activity under solvent effect: density functional theory study.

Journal of molecular modeling, 2022, Aug-01, Volume: 28, Issue:8

The structural and antioxidant activity of two flavonols, namely, Fisetin and Robinetin, have been investigated employing the density functional theory (DFT) using B3LYP functional and 6-311++G (d, p) basis set. The calculations were performed in the gas phase and under the solvent effect of water, dimethylsulfoxide (DMSO), methanol, and benzene. The Hydrogen-Atom Transfer (HAT), single Electron Transfer Followed by Proton Transfer (SET-PT), and sequential Proton Loss Electron Transfer (SPLET) mechanisms were investigated to rationalize the radical scavenging capacities and to identify the favored antioxidant mechanism. Hence, the bond dissociation enthalpies (BDE) ionization potential (IP), IE, proton dissociation enthalpy (PDE), proton affinity (PA), and electron Transfer enthalpy (ETE) related to each mechanism were reported and discussed in function of the solvent effect. For both flavonols, the results showed that 4'-OH hydroxyl is the preferred active site following the trend 4'-OH > 3'-OH > 3-OH > (5'-OH) > 7-OH. Besides, the HAT mechanism is energetically the most favored pathway. The energetically favored solvents follow the trends water > DMSO > benzene > methanol and benzene > DMSO > methanol > water, for Fisetin and Robinetin, respectively.

Topics: Antioxidants; Benzene; Density Functional Theory; Dimethyl Sulfoxide; Flavonoids; Flavonols; Hydrogen; Methanol; Protons; Solvents; Thermodynamics; Water

2022

Relationships between structures of hydroxyflavones and their antioxidative effects.

Bioorganic & medicinal chemistry letters, 2010, Sep-15, Volume: 20, Issue:18

Even hydroxyflavones show diverse biological functions, they have two common features such as showing antioxidative effects and containing hydroxyl groups. The authors tested the antioxidative effects of thirty hydroxyflavones using 1,1-diphenyl-2-picrylhydrazyl radical scavenging assay. While the scavenging activity of galangin, 3,5,7-trihydroxyflavone was 52.5%, fisetin, 3,7,3',4'-tetrahydroxyflavone showed 85.2%. To investigate the relationships between the structures of hydroxyflavones and their antioxidative effects, the three-dimensional quantitative structure-activity relationships were examined.

Topics: Antioxidants; Flavones; Flavonoids; Flavonols; Free Radical Scavengers; Models, Molecular; Quantitative Structure-Activity Relationship

2010