Compounds > ro 5-4864

ro 5-4864 and pregnenolone

ro 5-4864 has been researched along with pregnenolone in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (72.73)18.2507
2000's1 (9.09)29.6817
2010's2 (18.18)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cavallaro, S; Costa, E; Guidotti, A; Korneyev, A1
Costa, E; Guarneri, P; Pan, B; Papadopoulos, V1
Ambrosio, C; Barbaccia, ML; Massotti, M; Roscetti, G; Trabucchi, M1
Gee, KW; Lan, NC; McCauley, LD; Park, CH; Shively, JE; Tomich, JM1
Antkiewicz-Michaluk, L; Martin, B; Slobodyansky, E1
Cavallaro, S; Costa, E; Guidotti, A; Korneyev, A; Kozikowski, AP; Ma, D; Polo, A; Romeo, E1
Bender, AS; Norenberg, MD1
Benavides, J; Brault, E; Dalibert, I; Ferzaz, B; Gandolfo, P; Lacor, P; Schumacher, M; Tonon, MC1
Bianchi, R; Carozzi, V; Caruso, D; Cavaletti, G; Garcia-Segura, LM; Giatti, S; Lauria, G; Lombardi, R; Maschi, O; Melcangi, RC; Pesaresi, M1
Barresi, E; Costa, B; Da Pozzo, E; Da Settimo, F; Giacomelli, C; Martini, C; Taliani, S1
Chen, SL; Liu, XG; Wei, XH; Zang, Y; Zheng, WH1

Other Studies

11 other study(ies) available for ro 5-4864 and pregnenolone

ArticleYear
Diazepam-binding inhibitor (DBI)-processing products, acting at the mitochondrial DBI receptor, mediate adrenocorticotropic hormone-induced steroidogenesis in rat adrenal gland.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Nov-15, Volume: 89, Issue:22

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Amino Acid Sequence; Animals; Benzodiazepinones; Convulsants; Corticosterone; Cyclic AMP; Cycloheximide; Diazepam Binding Inhibitor; Hypophysectomy; Isoquinolines; Male; Mitochondria; Molecular Sequence Data; Neuropeptides; Pregnenolone; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; RNA

1992
Regulation of pregnenolone synthesis in C6-2B glioma cells by 4'-chlorodiazepam.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Jun-01, Volume: 89, Issue:11

    Topics: Animals; Benzodiazepinones; Cholesterol; Diazepam Binding Inhibitor; Glioma; In Vitro Techniques; Lovastatin; Mitochondria; Neuropeptides; Pregnenolone; Rats; Receptors, Cell Surface; Time Factors; Tumor Cells, Cultured

1992
Modulatory mechanisms of cyclic AMP-stimulated steroid content in rat brain cortex.
    European journal of pharmacology, 1994, Sep-15, Volume: 269, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Adrenalectomy; Animals; Benzodiazepinones; Bucladesine; Cerebral Cortex; Colforsin; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; In Vitro Techniques; Isoquinolines; Male; Orchiectomy; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear

1994
Benzodiazepines and peptides stimulate pregnenolone synthesis in brain mitochondria.
    European journal of pharmacology, 1995, Mar-24, Volume: 276, Issue:1-2

    Topics: Amino Acid Sequence; Animals; Benzodiazepines; Benzodiazepinones; Brain; In Vitro Techniques; Isoquinolines; Male; Mitochondria; Molecular Sequence Data; Peptides; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

1995
Purification of a novel DBI processing product, DBI39-75, and characterization of its binding site in rat brain.
    Regulatory peptides, 1994, Feb-03, Volume: 50, Issue:1

    Topics: Amino Acid Sequence; Animals; Benzodiazepinones; Binding Sites; Brain; Carrier Proteins; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Diazepam Binding Inhibitor; Isoquinolines; Male; Mitochondria; Molecular Sequence Data; Neuropeptides; Peptide Fragments; Pregnenolone; Radioligand Assay; Rats; Rats, Sprague-Dawley

1994
Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:1

    Topics: Adrenal Glands; Adrenalectomy; Animals; Behavior, Animal; Benzodiazepinones; Binding, Competitive; Brain; Carrier Proteins; Corticosterone; Diazepam Binding Inhibitor; In Vitro Techniques; Indoleacetic Acids; Isoquinolines; Male; Mitochondria; Orchiectomy; Pregnenolone; Rats; Rats, Sprague-Dawley; Solubility; Steroids; Tricarboxylic Acids

1993
Effect of benzodiazepines and neurosteroids on ammonia-induced swelling in cultured astrocytes.
    Journal of neuroscience research, 1998, Dec-01, Volume: 54, Issue:5

    Topics: Ammonia; Astrocytes; Atrial Natriuretic Factor; Benzodiazepines; Benzodiazepinones; Brain Edema; Cell Size; Clonazepam; Dehydroepiandrosterone Sulfate; Desoxycorticosterone; Diazepam; Diazepam Binding Inhibitor; Flumazenil; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Isoquinolines; Nerve Tissue Proteins; Neuropeptides; Peptide Fragments; Pregnanolone; Pregnenolone; Protoporphyrins; Receptors, GABA-A; Steroids; Up-Regulation

1998
Regulation of the expression of peripheral benzodiazepine receptors and their endogenous ligands during rat sciatic nerve degeneration and regeneration: a role for PBR in neurosteroidogenesis.
    Brain research, 1999, Jan-02, Volume: 815, Issue:1

    Topics: Animals; Antineoplastic Agents; Benzodiazepinones; Chromatography, High Pressure Liquid; Convulsants; Diazepam Binding Inhibitor; Freezing; Gene Expression Regulation; Isoquinolines; Ligands; Myelin Sheath; Nerve Regeneration; Neuropeptides; Peptide Fragments; Pregnenolone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sciatic Nerve; Tritium; Wallerian Degeneration

1999
Neuroprotective effects of a ligand of translocator protein-18 kDa (Ro5-4864) in experimental diabetic neuropathy.
    Neuroscience, 2009, Dec-01, Volume: 164, Issue:2

    Topics: Animals; Benzodiazepinones; Carrier Proteins; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dihydrotestosterone; Male; Neural Conduction; Neuroprotective Agents; Pregnenolone; Progesterone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; RNA, Messenger; Sciatic Nerve; Sciatic Neuropathy; Skin; Sodium-Potassium-Exchanging ATPase

2009
TSPO ligand residence time: a new parameter to predict compound neurosteroidogenic efficacy.
    Scientific reports, 2016, Jan-11, Volume: 6

    Topics: Anti-Anxiety Agents; Benzodiazepinones; Binding, Competitive; Cell Line, Tumor; Dose-Response Relationship, Drug; GABA Agonists; Gene Expression; Humans; Indoles; Isoquinolines; Kinetics; Ligands; Neuroglia; Pregnenolone; Protein Binding; Receptors, GABA; Thermodynamics; Time Factors; Tritium

2016
Inhibition of Neuropathic Pain by a Single Intraperitoneal Injection of Diazepam in the Rat: Possible Role of Neurosteroids.
    The Chinese journal of physiology, 2016, 02-29, Volume: 59, Issue:1

    Topics: Animals; Benzodiazepinones; Carrier Proteins; Diazepam; Flumazenil; Injections, Intraperitoneal; Interleukin-1beta; Male; Neuralgia; Neurotransmitter Agents; Pregnenolone; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2016