ro 48-8071 has been researched along with simvastatin in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aebi, JD; Dehmlow, H; Gains, N; Himber, J; Ji, YH; Lengsfeld, H; Morand, OH | 1 |
| Gayen, AK; Morand, OH; Peffley, DM | 1 |
| Chuang, JC; Lopez, AM; Posey, KS; Repa, JJ; Turley, SD; Valasek, MA | 1 |
3 other study(ies) available for ro 48-8071 and simvastatin
| Article | Year |
|---|---|
Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
Topics: Acetates; Animals; Apolipoproteins; Benzophenones; Cholesterol; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl CoA Reductases; Intramolecular Transferases; Lanosterol; Lipoproteins; Liver; Lovastatin; Myocardium; Osmolar Concentration; Saimiri; Simvastatin; Squalene; Swine; Swine, Miniature; Triglycerides; Tumor Cells, Cultured; Ubiquinone | 1997 |
Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4'-(6-allyl-ethyl-amino-hexyloxy)-2'-fluoro-phenyl]-(4-bromophenyl)-me thanone (Ro 48-8071):
Topics: Animals; Benzophenones; Cells, Cultured; Cricetinae; Down-Regulation; Enzyme Inhibitors; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Transferases; Lipoproteins, LDL; Mesocricetus; RNA, Messenger; Simvastatin | 1998 |
Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse.
Topics: Animals; Azetidines; Benzophenones; Cholesterol; Diet; Ezetimibe; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Mucosa; Intestine, Small; Intramolecular Transferases; Liver; Male; Mesocricetus; Mice; Mice, Inbred BALB C; Receptors, LDL; Simvastatin; Species Specificity | 2014 |