ro 48-8071 has been researched along with lanosterol in 3 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aebi, JD; Dehmlow, H; Gains, N; Himber, J; Ji, YH; Lengsfeld, H; Morand, OH | 1 |
| D'Arcy, B; Handschin, C; Kusznir, E; Morand, OH; Müller, F; Ruf, A; Stihle, M; Thoma, R | 1 |
| Aebi, J; Benz, J; D'Arcy, B; Dehmlow, H; Hennig, M; Ruf, A; Schulz-Gasch, T; Stihle, M; Thoma, R | 1 |
3 other study(ies) available for ro 48-8071 and lanosterol
| Article | Year |
|---|---|
Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin.
Topics: Acetates; Animals; Apolipoproteins; Benzophenones; Cholesterol; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl CoA Reductases; Intramolecular Transferases; Lanosterol; Lipoproteins; Liver; Lovastatin; Myocardium; Osmolar Concentration; Saimiri; Simvastatin; Squalene; Swine; Swine, Miniature; Triglycerides; Tumor Cells, Cultured; Ubiquinone | 1997 |
The monotopic membrane protein human oxidosqualene cyclase is active as monomer.
Topics: Benzophenones; Catalysis; Cell Membrane; Cholesterol; Detergents; DNA; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Humans; Inhibitory Concentration 50; Intramolecular Transferases; Lanosterol; Ligands; Microsomes, Liver; Pichia; Recombinant Proteins; Squalene; Ultracentrifugation | 2004 |
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase.
Topics: Anticholesteremic Agents; Benzophenones; Catalysis; Crystallography, X-Ray; Cyclization; Drug Design; Humans; Intramolecular Transferases; Lanosterol; Models, Molecular; Squalene; Structure-Activity Relationship | 2004 |