Compounds > ro 46-2005

Page last updated: 2024-09-03

ro 46-2005 and 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide

ro 46-2005 has been researched along with 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide in 4 studies

Compound Research Comparison

Studies (ro 46-2005)	Trials (ro 46-2005)	Recent Studies (post-2010) (ro 46-2005)	Studies (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)	Trials (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)	Recent Studies (post-2010) (5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide)
26	0	1	73	0	8

Protein Interaction Comparison

Protein	Taxonomy	ro 46-2005 (IC50)	5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide (IC50)
Endothelin-1 receptor	Homo sapiens (human)		0.23
Endothelin-1 receptor	Rattus norvegicus (Norway rat)		0.015

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Albrecht, HP; Amberg, W; Baumann, E; Bernard, H; Böhm, HJ; Kling, A; Klinge, D; Müller, S; Raschack, M; Riechers, H; Unger, L; Walker, N; Wernet, W	1
Alldus, C; Buchan, KW; Christodoulou, C; Clark, KL; Dykes, CW; Sumner, MJ; Wallace, DM; Watts, IS; White, DG	1
Amann, K; Gehlen, F; Münter, K; Nabokov, A; Ritz, E; Wagner, J	1
Amann, K; Münter, K; Nabokov, AV; Ritz, E; Wagner, J; Wessels, S	1

Other Studies

4 other study(ies) available for ro 46-2005 and 5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide

Article	Year
Discovery and optimization of a novel class of orally active nonpeptidic endothelin-A receptor antagonists. Journal of medicinal chemistry, 1996, May-24, Volume: 39, Issue:11 Topics: Administration, Oral; Animals; Dansyl Compounds; Death, Sudden; Drug Design; Endothelin Receptor Antagonists; Endothelins; Humans; Ligands; Models, Molecular; Molecular Structure; Pyrimidines; Rats; Receptor, Endothelin A; Receptors, Endothelin; Structure-Activity Relationship; Sulfonamides	1996
Characterization of three non-peptide endothelin receptor ligands using human cloned ETA and ETB receptors. British journal of pharmacology, 1994, Volume: 112, Issue:4 Topics: Animals; Base Sequence; Binding Sites; CHO Cells; Cloning, Molecular; Cricetinae; Dansyl Compounds; Endothelin Receptor Antagonists; Endothelins; Humans; Indans; Ligands; Molecular Sequence Data; Pyrimidines; Receptors, Endothelin; Sulfonamides	1994
Influence of specific and non-specific endothelin receptor antagonists on renal morphology in rats with surgical renal ablation. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1996, Volume: 11, Issue:3 Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Base Sequence; Blood Pressure; Dansyl Compounds; DNA Primers; Endothelin Receptor Antagonists; Endothelins; Glomerulosclerosis, Focal Segmental; Hypertrophy; Indoles; Kidney Glomerulus; Male; Molecular Sequence Data; Nephrectomy; Polymerase Chain Reaction; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; RNA, Messenger; Sulfonamides	1996
Endothelin receptor antagonists influence cardiovascular morphology in uremic rats. Kidney international, 1999, Volume: 55, Issue:2 Topics: Animals; Arteries; Coronary Vessels; Dansyl Compounds; Endothelin Receptor Antagonists; Heart; Male; Myocardium; Pyrimidines; Rats; Rats, Sprague-Dawley; Sulfonamides; Uremia	1999