ro 31-8220 has been researched along with h 89 in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (27.59) | 18.2507 |
| 2000's | 16 (55.17) | 29.6817 |
| 2010's | 5 (17.24) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Cox, KJ; Gaj, A; Ghosh, I; Jester, BW; Shomin, CD | 1 |
| Bunn, SJ; Saunders, HI | 1 |
| Lambert, DG; Smart, D | 2 |
| Lerner, MR; McClintock, TS; Rising, JP | 1 |
| Malendowicz, LK; Markowska, A; Mazzocchi, G; Nussdorfer, GG; Rebuffat, P; Rossi, GP | 1 |
| Giembycz, MA; Hellewell, PG; Lindsay, MA; Teixeira, MM | 1 |
| Choy, PC; Geiger, JD; Golfman, LS; Haughey, NJ; Jiang, JY; Lee, D; Wong, JT | 1 |
| Anwyl, R; Huang, LQ; Rowan, MJ | 1 |
| Caivano, M; Cohen, P | 1 |
| Lesslauer, W; Mary, JL; Tomás-Zuber, M | 1 |
| Board, M; Cawthorne, MA; Doyle, P | 1 |
| Hermans, E; Maloteaux, JM; Najimi, M; Page, G; Peeters, M | 1 |
| Hirata , K; Inoue, N; Kawashima, S; Kojima, Y; Rikitake, Y; Shimokawa, Y; Takeuchi, S; Yokoyama, M | 1 |
| Hannan, KM; Marmy-Conus, N; Pearson, RB | 1 |
| Pacheco, MA; Pastoor, TE; Wecker, L | 1 |
| Hadzopoulou-Cladaras, M; Lazou, A; Markou, T | 1 |
| Adamy, C; Ait-Mamar, B; Bouabdallah, A; Cailleret, M; Candiani, G; Defer, N; Duvaldestin, P; Pavoine, C; Pecker, F; Rucker-Martin, C | 1 |
| Chen, YH; Tsai, MC | 1 |
| Honan, SA; McNaughton, PA | 1 |
| Bahr, BA; Pin, SS | 1 |
| Bal, MS; Kunes, J; Paulis, L; Zicha, J | 1 |
| Adachi, M; Fujita, J; Hizawa, N; Homma, T; Huang, SK; Kawaguchi, M; Kokubu, F; Matsukura, S | 1 |
| Avni, D; Meijler, MM; Philosoph, A; Zor, T | 1 |
| Arthur, JS; Darragh, J; Macdonald, A; McCoy, CE; Naqvi, S; Reith, AD | 1 |
| Brown, AJ; Bucknall, MP; Kristiana, I; Luu, W; Sharpe, LJ; Zerenturk, EJ | 1 |
| Boytseva, EN; Denisenko, VY; Kuzmina, TI | 1 |
29 other study(ies) available for ro 31-8220 and h 89
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
Testing the promiscuity of commercial kinase inhibitors against the AGC kinase group using a split-luciferase screen.
Topics: Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Databases, Factual; Genes, Reporter; Luciferases; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Recombinant Fusion Proteins; Structure-Activity Relationship | 2012 |
Staurosporine inhibits inositol phosphate formation in bovine adrenal medullary cells.
Topics: Adrenal Medulla; Alkaloids; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Enzyme Activation; Enzyme Inhibitors; Histamine; Indoles; Inositol Phosphates; Isoquinolines; Norepinephrine; Protein Kinase C; Signal Transduction; Staurosporine; Sulfonamides; Type C Phospholipases | 1995 |
Mu-opioid activation of phospholipase C in SH-SY5Y cells rapidly desensitizes: mechanistic studies.
Topics: 4-Aminopyridine; Calcium; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Fentanyl; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Isoquinolines; Protein Kinase C; Receptors, Opioid, mu; Sulfonamides; Type C Phospholipases | 1995 |
Desensitization of the mu-opioid activation of phospholipase C in SH-SY5Y cells: the role of protein kinases C and A and Ca(2+)-activated K+ currents.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics, Opioid; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Fentanyl; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Isoquinolines; Narcotics; Neuroblastoma; Nifedipine; Potassium Channels; Protein Kinase C; Receptors, Opioid, mu; Sensitivity and Specificity; Sulfonamides; Tumor Cells, Cultured; Type C Phospholipases | 1995 |
Melanophore pigment dispersion responses to agonists show two patterns of sensitivity to inhibitors of cAMP-dependent protein kinase and protein kinase C.
Topics: Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Indoles; Isoquinolines; Melanophores; Protein Kinase C; Receptors, Bombesin; Second Messenger Systems; Signal Transduction; Sulfonamides; Xenopus | 1996 |
Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathways.
Topics: Animals; Catechols; Cell Division; Cyclooxygenase Inhibitors; DNA; Endothelin Receptor Antagonists; Endothelin-1; Endothelin-2; Endothelin-3; Endothelins; Enzyme Inhibitors; Indoles; Isoquinolines; Male; Mitotic Index; Nitriles; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Protein Kinase C; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Signal Transduction; Sulfonamides; Thymidine; Tyrphostins; Viper Venoms; Zona Glomerulosa | 1997 |
Pertussis toxin shows distinct early signalling events in platelet-activating factor-, leukotriene B4-, and C5a-induced eosinophil homotypic aggregation in vitro and recruitment in vivo.
Topics: Animals; Calcium; Cell Aggregation; Chemotactic Factors; Chemotaxis, Leukocyte; Complement C5a; Enzyme Inhibitors; Eosinophils; Female; GTP-Binding Proteins; Guinea Pigs; Indoles; Isoenzymes; Isoquinolines; Leukotriene B4; Pertussis Toxin; Phospholipase C beta; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine; Sulfonamides; Type C Phospholipases; Virulence Factors, Bordetella | 1997 |
Lysophosphatidylcholine induces arachidonic acid release and calcium overload in cardiac myoblastic H9c2 cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Cell Line; Enzyme Inhibitors; Flavonoids; Indoles; Isoquinolines; Kinetics; Lysophosphatidylcholines; Myocardium; Nimodipine; Phospholipases A; Protein Kinase C; Rats; Staurosporine; Structure-Activity Relationship; Sulfonamides | 1999 |
Role of protein kinases A and C in the induction of mGluR-dependent long-term depression in the medial perforant path of the rat dentate gyrus in vitro.
Topics: Animals; Carbazoles; Cyclic AMP-Dependent Protein Kinases; Dentate Gyrus; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; In Vitro Techniques; Indoles; Isoquinolines; Long-Term Potentiation; Maleimides; Neural Inhibition; Perforant Pathway; Protein Kinase C; Pyrroles; Rats; Receptors, Metabotropic Glutamate; Sulfonamides | 1999 |
Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1 beta in RAW264 macrophages.
Topics: Activating Transcription Factor 1; Animals; Calcium-Calmodulin-Dependent Protein Kinases; CCAAT-Enhancer-Binding Proteins; Cell Line; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA-Binding Proteins; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Indoles; Interleukin-1; Isoenzymes; Isoquinolines; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinases; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sulfonamides; Transcription Factors | 2000 |
Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor.
Topics: Amino Acid Sequence; Catalytic Domain; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; HeLa Cells; Humans; Indoles; Insulin; Ionomycin; Isoquinolines; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Phosphorylation; Protein Binding; Protein Kinase C; Protein Structure, Tertiary; Recombinant Proteins; Ribosomal Protein S6 Kinases; Serine; Signal Transduction; Substrate Specificity; Sulfonamides; Tetradecanoylphorbol Acetate; Threonine; Tumor Necrosis Factor-alpha | 2000 |
BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro.
Topics: Adrenergic beta-Agonists; Animals; Carbon Dioxide; Carbon Radioisotopes; Citric Acid Cycle; Deoxyglucose; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanolamines; Glucose; Glucose-6-Phosphate; In Vitro Techniques; Indoles; Isoquinolines; Mice; Mice, Obese; Muscle, Skeletal; Oxidation-Reduction; Palmitates; Phosphorylation; Propanolamines; Protein Kinase C; Pyruvic Acid; Sulfonamides | 2000 |
Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Carrier Proteins; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; Indoles; Isoquinolines; Kinetics; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Neurons; Phosphorylation; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Staurosporine; Sulfonamides; Synaptosomes; Tetradecanoylphorbol Acetate | 2001 |
Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine.
Topics: Activating Transcription Factor 1; Animals; Cattle; Cells, Cultured; Cyclic AMP Response Element-Binding Protein; Cyclooxygenase 2; DNA-Binding Proteins; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Imidazoles; Indoles; Isoenzymes; Isoquinolines; Lysophosphatidylcholines; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Pyridines; RNA, Messenger; Sulfonamides; Transcription Factors; Up-Regulation | 2001 |
Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling.
Topics: Animals; Cell Line; Enzyme Activation; Enzyme Inhibitors; Fibroblasts; Humans; Indoles; Isoquinolines; Kidney; Maleimides; Mice; Mice, Inbred BALB C; Mutagenesis, Site-Directed; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Sirolimus; Structure-Activity Relationship; Sulfonamides; TOR Serine-Threonine Kinases; Transfection | 2002 |
Phosphorylation of the alpha4 subunit of human alpha4beta2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC).
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Carcinogens; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Indoles; Isoquinolines; Neurons; Phosphorylation; Protein Kinase C; Receptors, Nicotinic; Sulfonamides; Tetradecanoylphorbol Acetate; Thionucleotides; Transfection | 2003 |
Phenylephrine induces activation of CREB in adult rat cardiac myocytes through MSK1 and PKA signaling pathways.
Topics: Adrenergic Agonists; Adrenergic alpha-1 Receptor Agonists; Animals; Atrial Natriuretic Factor; Cardiomegaly; CREB-Binding Protein; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Immunoprecipitation; Indoles; Isoquinolines; Mitogen-Activated Protein Kinase 3; Myocytes, Cardiac; Nuclear Proteins; p38 Mitogen-Activated Protein Kinases; Phenylephrine; Phosphorylation; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta; Ribosomal Protein S6 Kinases, 90-kDa; RNA, Messenger; Signal Transduction; Sulfonamides; Trans-Activators | 2004 |
The cytosolic phospholipase A2 pathway, a safeguard of beta2-adrenergic cardiac effects in rat.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium-Transporting ATPases; Caveolin 1; Caveolin 3; Caveolins; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Ethanolamines; Immunoblotting; Immunohistochemistry; Indoles; Isoquinolines; Lysophospholipase; Microscopy, Confocal; Myocardium; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Phospholipases A; Phospholipases A2; Phosphorylation; Rats; Receptors, Adrenergic, beta-2; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Serine; Sulfonamides; Time Factors | 2005 |
(+/-)3,4-Methylenedioxyamphetamine elicits action potential bursts in a central snail neuron.
Topics: Action Potentials; Alkaloids; Animals; Benzophenanthridines; Calcium; Carbazoles; Electrophysiology; Enzyme Inhibitors; Estrenes; Ganglia, Invertebrate; Hallucinogens; In Vitro Techniques; Indoles; Isoquinolines; Magnesium; N-Methyl-3,4-methylenedioxyamphetamine; Neurons; Patch-Clamp Techniques; Phosphodiesterase Inhibitors; Protein Kinase C; Pyrroles; Pyrrolidinones; Snails; Sulfonamides; Tetradecanoylphorbol Acetate | 2007 |
Sensitisation of TRPV1 in rat sensory neurones by activation of SNSRs.
Topics: Adenosine Triphosphate; Animals; Calcium; Capsaicin; Cattle; Enkephalin, Methionine; Ganglia, Spinal; Hot Temperature; Immunohistochemistry; Indoles; Isoenzymes; Isoquinolines; Membrane Potentials; Neurons, Afferent; Nociceptors; Patch-Clamp Techniques; Protein Kinase C; Protein Precursors; Rats; Signal Transduction; Sulfonamides; TRPV Cation Channels | 2007 |
Protein kinase C is a common component of CGRP receptor desensitization induced by distinct agonists.
Topics: Adenylyl Cyclases; Adrenomedullin; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Carbazoles; Cell Membrane; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Indoles; Isoquinolines; Kinetics; Ligands; Protein Kinase C; Pyrroles; Receptors, Calcitonin Gene-Related Peptide; Sulfonamides | 2008 |
Effect of protein kinase C and protein kinase A inhibitors on contraction of isolated femoral arteries of SHR and Wistar rats.
Topics: Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Femoral Artery; Hypertension; In Vitro Techniques; Indoles; Isoquinolines; Male; Norepinephrine; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Wistar; Sulfonamides; Vasoconstriction; Vasoconstrictor Agents | 2009 |
IL-17F-induced IL-11 release in bronchial epithelial cells via MSK1-CREB pathway.
Topics: Bronchi; Cell Line; Cyclic AMP Response Element-Binding Protein; Enzyme Activation; Epithelial Cells; Gene Expression Regulation; Humans; Indoles; Interleukin-11; Interleukin-13; Interleukin-17; Interleukin-4; Isoquinolines; Kinetics; Ribosomal Protein S6 Kinases, 90-kDa; Sulfonamides; Th2 Cells | 2009 |
The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner.
Topics: Adenylyl Cyclases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bucladesine; Calcium Signaling; Cell Line; Cell Membrane; Ceramides; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Enzyme Inhibitors; Genes, Reporter; Guanosine Triphosphate; Imidazoles; Indoles; Interleukin-10; Isoquinolines; Lipopolysaccharides; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Response Elements; Ribosomal Protein S6 Kinases, 90-kDa; Rolipram; Signal Transduction; Sulfonamides; Transfection; Tumor Necrosis Factor-alpha | 2010 |
Characterization of the cellular action of the MSK inhibitor SB-747651A.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cytokines; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Indoles; Isoquinolines; Macrophages; Mice; Molecular Structure; Oxadiazoles; Rats; Ribosomal Protein S6 Kinases, 90-kDa; Sulfonamides | 2012 |
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis.
Topics: Animals; Binding Sites; Blotting, Western; CHO Cells; Cholesterol; Cricetinae; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Desmosterol; Gene Expression; Humans; Indoles; Isoquinolines; Mutation; Nerve Tissue Proteins; Oxidoreductases Acting on CH-CH Group Donors; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Sulfonamides; Tyrosine | 2014 |
[Mobilization of Ca2+ from intracellular stores of spermatozoa of Bos taurus depending on their functional status].
Topics: Acrosome Reaction; Animals; Calcium; Calcium Signaling; Cattle; Cells, Cultured; Chlortetracycline; Cyclic AMP-Dependent Protein Kinases; Fluorescent Dyes; Guanosine Triphosphate; Indoles; Isoquinolines; Lysophosphatidylcholines; Male; Prolactin; Protein Kinase C; Sperm Capacitation; Spermatozoa; Sulfonamides; Theophylline | 2015 |