ro 31-8220 and bisindolylmaleimide i

Topics: Animals; Cell Differentiation; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; Neoplasms; Nervous System Diseases; Parasitic Diseases; Signal Transduction; Stem Cells; Structure-Activity Relationship

Topics: Azepines; Bryostatins; Carbazoles; Enzyme Inhibitors; Humans; Hydroxybenzoates; Indoles; Lactones; Macrolides; Maleimides; Oligodeoxyribonucleotides, Antisense; Protein Kinase C; Pyrroles; Signal Transduction; Thionucleotides

Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides

Topics: Adenosine; Amino Acid Sequence; Binding Sites; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Morpholines; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Conformation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Sequence Alignment; Staurosporine

Topics: Antineoplastic Agents; Crystallization; Crystallography, X-Ray; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Models, Molecular; Molecular Structure; Moloney murine leukemia virus; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-pim-1; Proviruses; Pyrazoles; Pyridazines; Pyrimidines; Structure-Activity Relationship

Topics: Acetylation; Adenosine; Binding Sites; Cell Line, Tumor; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Models, Molecular; Molecular Mimicry; Protein Kinase Inhibitors; Sirtuins; Structure-Activity Relationship; Tubulin

Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers

Topics: Animals; Binding, Competitive; Catalytic Domain; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Databases, Factual; Genes, Reporter; Luciferases; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; Recombinant Fusion Proteins; Structure-Activity Relationship

Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Humans; Models, Biological; Organic Chemicals; Regression Analysis; Support Vector Machine

Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Glycogen Synthase Kinase 3; Humans; Maleimides; Molecular Structure; Protein Kinase Inhibitors; Structure-Activity Relationship

Topics: Drug Discovery; Organic Chemicals; Pharmaceutical Preparations; Solubility

Topics: Animals; Computer Simulation; Databases, Factual; Drug Discovery; High-Throughput Screening Assays; Liver; Machine Learning; Male; Microsomes, Liver; National Center for Advancing Translational Sciences (U.S.); Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Rats; Rats, Sprague-Dawley; Retrospective Studies; United States

Topics: Alkaloids; B-Lymphocytes; Blotting, Western; Cell Line; Cell Movement; Cells, Cultured; Enzyme Activation; Humans; Indoles; Lymphocytes; Maleimides; Marine Toxins; Oxazoles; Phenotype; Phosphoprotein Phosphatases; Protein Kinase C; Staurosporine; T-Lymphocytes

Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Carcinogens; Cerebral Cortex; Cytosol; Diterpenes; Female; Growth Hormone; Indoles; Isomerism; Isoquinolines; Lung; Luteinizing Hormone; Maleimides; Phenanthridines; Phorbol 12,13-Dibutyrate; Piperazines; Pituitary Gland, Anterior; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Terpenes; Tritium

Topics: Alkaloids; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Division; Cell Line; Doxorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Fluorescent Dyes; Humans; Indoles; Maleimides; Protein Kinase C; Rhodamine 123; Rhodamines; Staurosporine; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine

Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cell Line; Dual Specificity Phosphatase 1; Enzyme Activation; Enzyme Inhibitors; Immediate-Early Proteins; Indoles; JNK Mitogen-Activated Protein Kinases; Maleimides; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats

Topics: Amino Acid Sequence; Animals; Cell Line; Enzyme Inhibitors; Indoles; Isoenzymes; Kinetics; Liver; Maleimides; Molecular Sequence Data; Peptides; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Recombinant Proteins; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Spodoptera; Transfection

Topics: Aging; Animals; Animals, Newborn; Becaplermin; Cattle; Cell Division; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; Fetus; Humans; Hypoxia; Indoles; Insulin-Like Growth Factor I; Isoenzymes; Maleimides; Muscle Development; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Proto-Oncogene Proteins c-sis; Pulmonary Artery; Recombinant Proteins; Signal Transduction

Topics: Alkaloids; Antineoplastic Agents; Blotting, Western; Cell Membrane; Cell Nucleus; Cytosol; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Humans; Indoles; Isoenzymes; Maleimides; Microscopy, Confocal; Models, Chemical; Protein Kinase C; Protein Kinase C-theta; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Zinc Fingers

Topics: Aging; Animals; Animals, Newborn; Calcium; Cattle; Cell Division; Cells, Cultured; Enzyme Inhibitors; Fetus; Fibroblasts; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Indoles; Isoenzymes; Maleimides; Organ Specificity; Protein Kinase C; Pulmonary Artery; Rabbits; Species Specificity

Topics: Animals; Astrocytes; Benzoquinones; Calcium-Calmodulin-Dependent Protein Kinases; CCAAT-Enhancer-Binding Proteins; Chemokines, CXC; Chemotactic Factors; DNA-Binding Proteins; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Glioma; Growth Inhibitors; Growth Substances; Indoles; Intercellular Signaling Peptides and Proteins; Interleukin-8; Lactams, Macrocyclic; Maleimides; Mitogen-Activated Protein Kinases; NF-kappa B; Nuclear Proteins; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Quinones; ras Proteins; Rats; Rifabutin; RNA, Messenger; Signal Transduction; Transcription Factors; Tumor Cells, Cultured

Topics: Animals; CHO Cells; Cricetinae; Enzyme Inhibitors; Humans; Indoles; Maleimides; Muscarinic Antagonists; Protein Kinase C; Radioligand Assay; Receptors, Muscarinic; Recombinant Proteins

Topics: Animals; Apoptosis; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle Proteins; Cells, Cultured; Cycloheximide; Drug Resistance; Dual Specificity Phosphatase 1; Enzyme Activation; Enzyme Inhibitors; Glomerular Mesangium; Immediate-Early Proteins; Indoles; JNK Mitogen-Activated Protein Kinases; Male; Maleimides; Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha

Topics: Enzyme Inhibitors; Humans; Indoles; Maleimides; Protein Kinase C; Receptors, Muscarinic; RGS Proteins; RNA, Messenger; Tumor Cells, Cultured

Topics: Adipocytes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Indoles; Male; Maleimides; Microtubule-Associated Proteins; Protein Kinase C; Rats; Rats, Wistar

Topics: Androstadienes; Carbazoles; CD18 Antigens; Cell Adhesion; Cell Count; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Eosinophils; Humans; Imidazoles; Indoles; Isoenzymes; Macrophage-1 Antigen; Maleimides; Mitogen-Activated Protein Kinases; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrazoles; Pyridines; Pyrimidines; Signal Transduction; src-Family Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin

Topics: Animals; Animals, Newborn; Cattle; Cell Division; Cells, Cultured; Chronic Disease; Enzyme Inhibitors; Fibroblasts; Hypertension, Pulmonary; Hypoxia; Indoles; Isoenzymes; Maleimides; Protein Kinase C; Protein Kinase C beta; Pulmonary Artery

Topics: Alanine; Aluminum Compounds; Animals; Blotting, Western; Bombesin; COS Cells; Enzyme Activation; Enzyme Inhibitors; Fluorides; Green Fluorescent Proteins; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Indoles; Luminescent Proteins; Maleimides; Mutagenesis, Site-Directed; Precipitin Tests; Protein Kinase C; Receptors, Bombesin; Recombinant Fusion Proteins; Serine; Signal Transduction; Transfection

Topics: 3T3 Cells; Animals; Enzyme Activation; Enzyme Inhibitors; Estrenes; GTP-Binding Proteins; Indoles; Lysophospholipids; Maleimides; MAP Kinase Signaling System; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphodiesterase Inhibitors; Phosphorylation; Protein Kinase C; Pyrrolidinones; Rats; Virulence Factors, Bordetella

Topics: Animals; Blood Platelets; Carbazoles; Cattle; Cytoplasmic Granules; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Group IV Phospholipases A2; Humans; Imidazoles; Indoles; Indomethacin; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Phospholipases A; Phospholipases A2; Phosphorylation; Platelet Aggregation; Protein Kinase C; Protein Processing, Post-Translational; Pyridines; Serotonin; Serum Albumin, Bovine; Thrombin; Thrombopoietin; Thromboxane A2

Topics: Animals; Calcium; COS Cells; Edetic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrogen Peroxide; Indoles; Isoenzymes; K562 Cells; Kinetics; Leukemia L1210; Maleimides; Mice; Phospholipase D; Protein Kinase C; Protein Kinase C-alpha; Recombinant Proteins; Transfection; U937 Cells

Topics: Animals; Binding, Competitive; Cerebral Cortex; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Glutamic Acid; Indoles; Maleimides; Membrane Potentials; Neurons; Patch-Clamp Techniques; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Synaptosomes; Veratridine

Topics: CD55 Antigens; Cells, Cultured; Complement Activation; Complement System Proteins; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Feedback; Flavonoids; Gene Expression Regulation; Humans; Imidazoles; Indoles; Inflammation; Lymphokines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; NF-kappa B; Oligopeptides; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Receptor, PAR-1; Receptors, Thrombin; Recombinant Proteins; RNA, Messenger; Thrombin; Thrombosis; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Dactinomycin; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Humans; Indoles; Kinetics; Luciferases; Maleimides; Okadaic Acid; Promoter Regions, Genetic; Protein Kinase C; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Transfection; Tumor Suppressor Protein p53; U937 Cells

Topics: Blood Platelets; Enzyme Inhibitors; Humans; In Vitro Techniques; Indoles; Isoenzymes; L-Lactate Dehydrogenase; Maleimides; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Protein Kinase C-delta; Protein Kinases; Thrombin

Topics: Cell Division; Cells, Cultured; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Fibroblast Growth Factors; Humans; Indoles; Lymphokines; Maleimides; Plasminogen Activators; Protein Kinase C; Receptors, Cell Surface; Receptors, Urokinase Plasminogen Activator; Signal Transduction; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

Topics: Calcium; Cell Hypoxia; Chronic Disease; Electric Stimulation; Enzyme Inhibitors; Exocytosis; Humans; Hypoxia, Brain; Indoles; Maleimides; Membrane Potentials; Muscarine; Muscarinic Agonists; Neuroblastoma; Neurons; Norepinephrine; Potassium; Protein Kinase C; Receptors, Muscarinic; Stimulation, Chemical; Tritium; Tumor Cells, Cultured

Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Cerebral Cortex; Enzyme Inhibitors; Fibroblast Growth Factor 2; Indoles; Kinetics; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Models, Biological; Norepinephrine; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-raf; Rats; Serotonin; Tetradecanoylphorbol Acetate

Topics: Amides; Amino Acid Sequence; Animals; Aorta; Carbazoles; Chromatography; Chromatography, Affinity; Chromatography, Ion Exchange; Durapatite; Enzyme Activation; Enzyme Inhibitors; Histamine; In Vitro Techniques; Indoles; Isoenzymes; Kinetics; Maleimides; Molecular Sequence Data; Muscle Contraction; Muscle Proteins; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Myelin Basic Protein; Myosin-Light-Chain Phosphatase; Peptide Fragments; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Pyridines; Recombinant Proteins; Substrate Specificity; Swine; Vasoconstriction

Topics: Acetophenones; Benzopyrans; Bradykinin; Carbazoles; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Immunoblotting; Indoles; Isoenzymes; Kinetics; Maleimides; Phospholipase D; Phospholipids; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured

Topics: Animals; Cell Transformation, Neoplastic; Chlorocebus aethiops; COS Cells; Cyclin D1; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation, Enzymologic; Genes, ras; Humans; Indoles; Isoenzymes; Luciferases; Maleimides; Mammary Neoplasms, Experimental; Mice; Phospholipase D; Protein Binding; Protein Kinase C; Transfection

Topics: Androstadienes; Animals; Antibodies; Carbazoles; CD18 Antigens; Cell Adhesion; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Eosinophils; Flavonoids; Guinea Pigs; Imidazoles; Indoles; Integrin beta1; Intracellular Signaling Peptides and Proteins; Leukotriene B4; Macrophage-1 Antigen; Male; Maleimides; Mitogen-Activated Protein Kinases; NADPH Oxidases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein-Tyrosine Kinases; Pyrazoles; Pyridines; Pyrimidines; Rats; src-Family Kinases; Stilbenes; Syk Kinase; Time Factors; Wortmannin

Topics: Acetophenones; Adenoviridae; Animals; Benzopyrans; Bradykinin; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunoblotting; Immunohistochemistry; Indoles; Isoenzymes; Maleimides; Microscopy, Fluorescence; Mutation; PC12 Cells; Peptide Mapping; Phospholipase D; Phosphorylation; Precipitin Tests; Protein Binding; Protein Isoforms; Protein Kinase C; Protein Kinase C-delta; Protein Transport; Rats; Tetradecanoylphorbol Acetate; Time Factors; Up-Regulation

Topics: Alanine; Amino Acid Substitution; Animals; Catalytic Domain; COS Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Indoles; Isoenzymes; Jurkat Cells; Maleimides; Mutation; Phorbol 12,13-Dibutyrate; Precipitin Tests; Protein Kinase C; Protein Kinase C-theta; Serine; Signal Transduction; T-Lymphocytes; Transfection

Topics: Blotting, Western; Cell Line; Dose-Response Relationship, Radiation; Enzyme Induction; Epithelial Cells; Hot Temperature; Humans; Indoles; JNK Mitogen-Activated Protein Kinases; Lens, Crystalline; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Signal Transduction; Time Factors; Ultraviolet Rays

Topics: Carbazoles; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoglobulin G; Indoles; Maleimides; Microscopy, Fluorescence; NADPH Oxidases; Neutrophils; Oligonucleotides, Antisense; Oxygen; Oxygen Consumption; Phagocytosis; Phosphoproteins; Phosphorylation; Protein Kinase C; Receptors, IgG; Recombinant Proteins; Signal Transduction; Staphylococcus aureus

Topics: Androstadienes; Animals; Calcium; Cells, Cultured; Chromones; COS Cells; Enzyme Inhibitors; Indoles; Inositol Phosphates; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Receptors, Transforming Growth Factor beta; Staurosporine; Transforming Growth Factor beta; Wortmannin

Topics: Animals; Cell Division; Cells, Cultured; Chick Embryo; Cholecalciferol; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Immunoblotting; Indoles; Isoenzymes; Maleimides; MAP Kinase Signaling System; Models, Biological; Muscles; Naphthalenes; Oligonucleotides; Oligonucleotides, Antisense; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Kinase C-alpha; Proto-Oncogene Proteins c-raf; ras Proteins; RNA, Messenger; Serine; Time Factors; Transfection

Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin

Topics: Acetophenones; Animals; Aorta; Benzopyrans; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indoles; Kinetics; Maleimides; Muscle, Smooth, Vascular; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Pyridines; Rats; Thrombin

Topics: Acetylcholine; Adenosine; Amphibians; Animals; Binomial Distribution; Calcium; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Evoked Potentials; Indoles; Maleimides; Monte Carlo Method; Nerve Endings; Neuromuscular Junction; Neurotransmitter Agents; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Rana pipiens; Staurosporine; Synaptic Vesicles

Topics: Aequorin; Calcium; Carbachol; Cytosol; Down-Regulation; Endoplasmic Reticulum; Enzyme Inhibitors; HeLa Cells; Histamine; Humans; Imidazoles; Indoles; Inositol 1,4,5-Trisphosphate; Maleimides; Mitochondria; Oscillometry; Protein Kinase C; Pyridines; Staurosporine; Time Factors; Transfection

Topics: Arachidonic Acids; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Imidazoles; Indoles; Lipoproteins, LDL; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phospholipases A; Protein Kinase C; Pyridines; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction; src-Family Kinases; Type C Phospholipases; Umbilical Veins

Topics: Animals; COS Cells; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Genetic Vectors; Indoles; Maleimides; Phospholipase D; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-alpha; Serine; Subcellular Fractions; Tetradecanoylphorbol Acetate; Threonine; Time Factors; Transfection

Topics: Adenoviridae; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genetic Vectors; Heart Ventricles; Humans; Indoles; Isoenzymes; Male; Maleimides; MAP Kinase Kinase 1; Myocytes, Cardiac; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 90-kDa

Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; Carbazoles; Cell Membrane; Chlorocebus aethiops; COS Cells; Diglycerides; Estrenes; HeLa Cells; HL-60 Cells; Humans; Indoles; Maleimides; Membranes; Microscopy, Confocal; Phorbol 12,13-Dibutyrate; Protein Kinase C; Protein Transport; Pyrrolidinones; Staurosporine

Topics: Animals; Benzimidazoles; Calcium Signaling; Carbocyanines; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cholecystokinin; Cytochalasin D; Cytoskeleton; Depsipeptides; Dose-Response Relationship, Drug; Hydrogen Peroxide; Indoles; Intracellular Fluid; Male; Maleimides; Membrane Potential, Mitochondrial; Mice; Mitochondria; Oligomycins; Organotin Compounds; Pancreas, Exocrine; Protein Kinase C; Ruthenium Compounds; Salicylates; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sincalide; Thapsigargin

Topics: Animals; Bridged-Ring Compounds; Diglycerides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Immunoblotting; Indoles; Invertebrates; Isoenzymes; Maleimides; Neomycin; Norbornanes; Oocytes; Protein Kinase C; Seawater; Signal Transduction; Tetradecanoylphorbol Acetate; Thiocarbamates; Thiones

Topics: Analysis of Variance; Aryldialkylphosphatase; Blotting, Western; Cell Line; Cells, Cultured; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Humans; Immunoglobulins; Indoles; Isoenzymes; Maleimides; Promoter Regions, Genetic; Protein Kinase C; Quinolines; Transfection