ro 31-8220 has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 23 (85.19) | 29.6817 |
| 2010's | 1 (3.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caivano, M; Cohen, P; Davies, SP; Reddy, H | 1 |
| Black, J; Fleming, M; Futer, O; Hare, B; Jacobs, MD; Saxena, K; Swenson, L | 1 |
| Alessi, DR; Arthur, JS; Bain, J; Cohen, P; Elliott, M; Hastie, CJ; Klevernic, I; McLauchlan, H; Plater, L; Shpiro, N | 1 |
| Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
| Bandyopadhyay, G; Farese, RV; Galloway, L; Karnam, P; Moscat, J; Standaert, ML | 1 |
| Bandyopadhyay, G; Farese, R; Galloway, L; Mukai, H; Ono, Y; Standaert, M | 1 |
| Adomeit, A; Graness, A; Heinze, R; Liebmann, C; Wetzker, R | 1 |
| Barrett, KE; Chow, JY; Uribe, JM | 1 |
| Dickenson, JM; Germack, R | 1 |
| Alessi, DR; Cuenda, A | 1 |
| Corcos, L; Galisteo, M; Guillouzo, A; Joannard, F; Lagadic-Gossmann, D | 1 |
| Benard, V; Gendreau, S; Missy, K; Payrastre, B; Plantavid, M; Soulet, C | 1 |
| Atkinson, BT; Pears, CJ; Stafford, MJ; Watson, SP | 1 |
| Flores-Jasso, CF; García-Sáinz, JA; Romero-Avila, MT | 1 |
| Bazan, NG; Bernatchez, PN; Gélinas, DS; Rollin, S; Sirois, MG | 1 |
| Baek, SH; Chung, JH; Jeon, JY; Kim, YD; Lee, JC; Song, SY; Woo, HJ; Yoon, SK | 1 |
| Bressler, J; Olivi, L; Sisk, J | 1 |
| Anel, A; Boyer, C; Buferne, M; Martínez-Lorenzo, MJ; Naval, J; Pardo, J; Schmitt-Verhulst, AM | 1 |
| DiMattina, AJ; Holland, JA; Johnson, DK; O'Donnell, RW; Stone, RI; Ziegler, LM | 1 |
| Bae, YS; Kim, Y; Kita, H; Lee, YA; Ryu, SH; Shin, MH | 1 |
| Clugston, A; Dransfield, I; Haslett, C; Murray, J; Rossi, AG; Ward, C | 1 |
| MacGlashan, DW; Miura, K; Vilariño, N | 1 |
| Falcinelli, E; Gresele, P; Guglielmini, G; Torti, M | 1 |
| Håkansson, LD; Lampinen, M; Venge, P | 1 |
| Hemström, TH; Sandström, M; Zhivotovsky, B | 1 |
| Albert, AP; Large, WA; Saleh, SN | 1 |
| Au, LC; Chang, CL; Fai Kwok, C; Ho, LT; Huang, SW; Juan, CC | 1 |
1 review(s) available for ro 31-8220 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Use of kinase inhibitors to dissect signaling pathways.
Topics: Androstadienes; Animals; Chromones; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Maleimides; Morpholines; Protein Kinase Inhibitors; Pyridines; Signal Transduction; Sirolimus; Wortmannin | 2000 |
26 other study(ies) available for ro 31-8220 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Amides; Animals; Benzamides; Benzophenanthridines; Benzopyrans; Butadienes; Cell Line; Enzyme Inhibitors; Flavonoids; Humans; Imidazoles; Indoles; Inhibitory Concentration 50; Isoquinolines; Lithium; Magnesium; Nitriles; Phenanthridines; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Pyridines; Sirolimus; Substrate Specificity; Sulfonamides | 2000 |
Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.
Topics: Adenosine; Amino Acid Sequence; Binding Sites; Chromones; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Sequence Data; Molecular Structure; Morpholines; Phosphatidylinositol 3-Kinases; Protein Binding; Protein Conformation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-pim-1; Sequence Alignment; Staurosporine | 2005 |
The selectivity of protein kinase inhibitors: a further update.
Topics: Amino Acid Sequence; Animals; Cell Line; Drug Design; Enzyme Activation; Humans; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Recombinant Proteins; Spodoptera | 2007 |
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport.
Topics: Adipocytes; Androstadienes; Animals; Biological Transport; Chromones; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Glucose; Indoles; Insulin; Male; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Wortmannin | 1997 |
Comparative effects of GTPgammaS and insulin on the activation of Rho, phosphatidylinositol 3-kinase, and protein kinase N in rat adipocytes. Relationship to glucose transport.
Topics: Adipocytes; ADP Ribose Transferases; Androstadienes; Animals; Biological Transport; Botulinum Toxins; Chromones; Enzyme Inhibitors; Glucose; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Indoles; Insulin; Male; Morpholines; Phosphatidylinositol 3-Kinases; Protein Kinase C; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Wortmannin | 1998 |
A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon.
Topics: Bradykinin; Calcium-Calmodulin-Dependent Protein Kinases; Chromones; Colonic Neoplasms; Dimerization; DNA, Neoplasm; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Indoles; Inositol Phosphates; Isoenzymes; Kinetics; Macromolecular Substances; Maleimides; Models, Biological; Morpholines; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinase C-epsilon; Receptors, Bradykinin; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1998 |
A role for protein kinase cepsilon in the inhibitory effect of epidermal growth factor on calcium-stimulated chloride secretion in human colonic epithelial cells.
Topics: Androstadienes; Calcium; Carbachol; Chlorides; Chromones; Colon; Enzyme Inhibitors; Epidermal Growth Factor; Humans; Indoles; Intestinal Mucosa; Isoenzymes; Kinetics; Morpholines; Oligodeoxyribonucleotides, Antisense; Phosphatidylinositol Phosphates; Protein Kinase C; Protein Kinase C-epsilon; RNA, Messenger; Wortmannin | 2000 |
Activation of protein kinase B by the A(1)-adenosine receptor in DDT(1)MF-2 cells.
Topics: Adenosine; Androstadienes; Animals; Calcium; Cell Line; Chromones; Cricetinae; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Genistein; Imidazoles; Indoles; Insulin; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Morpholines; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Virulence Factors, Bordetella; Wortmannin; Xanthines | 2000 |
Regulation of phenobarbital-induction of CYP2B and CYP3A genes in rat cultured hepatocytes: involvement of several serine/threonine protein kinases and phosphatases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aryl Hydrocarbon Hydroxylases; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromones; Cyclic AMP; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Flavonoids; Genistein; Hepatocytes; Hydroquinones; Indoles; Intracellular Fluid; Morpholines; Okadaic Acid; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; RNA, Messenger; Signal Transduction | 2000 |
Characterisation of Rac activation in thrombin- and collagen-stimulated human blood platelets.
Topics: Benzylamines; Blood Platelets; Calcium; cdc42 GTP-Binding Protein; Cells, Cultured; Chromones; Collagen; Enzyme Activation; Enzyme Inhibitors; Epoprostenol; Estrenes; Humans; Indoles; Morpholines; Oligopeptides; p21-Activated Kinases; Phosphatidylinositol 3-Kinases; Piperidines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Kinase C; Protein Serine-Threonine Kinases; Pyrrolidinones; rac GTP-Binding Proteins; Thiazoles; Thrombin; Type C Phospholipases | 2001 |
Signalling components underlying platelet aggregation to a Ca2+ ionophore and a phorbol ester.
Topics: Adenosine Diphosphate; Androstadienes; Calcimycin; Calcium Signaling; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Humans; Indoles; Ionophores; Morpholines; Phosphatidylinositol 3-Kinases; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Serotonin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxanes; Type C Phospholipases; Wortmannin | 2001 |
alpha1B-Adrenergic receptor phosphorylation and desensitization induced by transforming growth factor-beta.
Topics: Androstadienes; Animals; Calcium; Cells, Cultured; Chromones; COS Cells; Enzyme Inhibitors; Indoles; Inositol Phosphates; Maleimides; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase C; Rats; Receptors, Adrenergic, alpha-1; Receptors, Transforming Growth Factor beta; Staurosporine; Transforming Growth Factor beta; Wortmannin | 2002 |
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2002 |
Interleukin-1beta induces MUC2 gene expression and mucin secretion via activation of PKC-MEK/ERK, and PI3K in human airway epithelial cells.
Topics: Cell Line; Chromones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Epithelium; Flavonoids; Humans; Imidazoles; Immunoassay; Immunoblotting; Indoles; Interleukin-1; Lung; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Morpholines; Mucin-2; Mucins; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Time Factors | 2002 |
The involvement of lipid activators of protein kinase C in the induction of ZIF268 in PC12 cells exposed to lead.
Topics: Androstadienes; Animals; Chromones; Diglycerides; DNA-Binding Proteins; Early Growth Response Protein 1; Enzyme Activation; Enzyme Inhibitors; Immediate-Early Proteins; Indoles; Lead; Morpholines; PC12 Cells; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; RNA, Messenger; Transcription Factors; Wortmannin | 2003 |
Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.
Topics: Acetophenones; Androstadienes; Animals; Antibodies, Monoclonal; Benzopyrans; Carbazoles; Cell Degranulation; Cell Line; Chromones; Cycloheximide; Cytotoxicity, Immunologic; Dactinomycin; Fas Ligand Protein; Humans; Indoles; Ionomycin; Isoenzymes; Jurkat Cells; Luciferases; Lymphocyte Activation; Membrane Glycoproteins; Mice; Morpholines; Perforin; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pore Forming Cytotoxic Proteins; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Kinase C-theta; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Signal Transduction; T-Lymphocytes, Cytotoxic; Transfection; Wortmannin | 2003 |
Endothelial NADPH oxidase: mechanism of activation by low-density lipoprotein.
Topics: Arachidonic Acids; Cells, Cultured; Chromones; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Humans; Imidazoles; Indoles; Lipoproteins, LDL; Maleimides; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Morpholines; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phospholipase C gamma; Phospholipases A; Protein Kinase C; Pyridines; Pyrrolidinones; Reactive Oxygen Species; Signal Transduction; src-Family Kinases; Type C Phospholipases; Umbilical Veins | 2003 |
The synthetic chemoattractant peptide WKYMVm induces superoxide production by human eosinophils via the phosphoinositide 3-kinase-mediated activation of ERK1/2.
Topics: Blotting, Western; Chromones; Enzyme Activation; Enzyme Inhibitors; Eosinophil Granule Proteins; Eosinophils; Flavonoids; Humans; Indoles; Mitogen-Activated Protein Kinase 3; Morpholines; Oligopeptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Stereoisomerism; Superoxides | 2005 |
Interleukin-10 inhibits lipopolysaccharide-induced survival and extracellular signal-regulated kinase activation in human neutrophils.
Topics: Apoptosis; Blotting, Western; Chromones; Drug Interactions; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Flow Cytometry; Humans; Imidazoles; Indoles; Interleukin-10; Lipopolysaccharides; Morpholines; Neutrophils; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Kinase Inhibitors; Pyridines | 2005 |
Acute IL-3 priming up-regulates the stimulus-induced Raf-1-Mek-Erk cascade independently of IL-3-induced activation of Erk.
Topics: Chromones; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Humans; Indoles; Interleukin-3; Leukotriene C4; MAP Kinase Kinase Kinases; Morpholines; Phosphorylation; Proto-Oncogene Proteins c-raf; Signal Transduction; Up-Regulation | 2005 |
Intraplatelet signaling mechanisms of the priming effect of matrix metalloproteinase-2 on platelet aggregation.
Topics: Androstadienes; Blood Platelets; Calcium; Chromones; Drug Synergism; Estrenes; Humans; In Vitro Techniques; Indoles; Inositol 1,4,5-Trisphosphate; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Protein Kinase C; Pyrrolidinones; Recombinant Proteins; Second Messenger Systems; Signal Transduction; Thrombin; Tissue Inhibitor of Metalloproteinase-2; Type C Phospholipases; Wortmannin | 2005 |
Albumin stimulation of eosinophil migration involves PI3-kinases and is associated with diminished eosinophil CD49d and CD49f expression.
Topics: Adult; Androstadienes; Cell Adhesion; Cell Size; Chemotaxis, Leukocyte; Chromones; Dose-Response Relationship, Immunologic; Eosinophils; Flow Cytometry; Humans; Indoles; Integrin alpha4; Integrin alpha6; Interleukin-2; Middle Aged; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Serum Albumin; Signal Transduction; Wortmannin | 2006 |
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells.
Topics: Androstadienes; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Survival; Chromones; Enzyme Inhibitors; Etoposide; Flavonoids; Flow Cytometry; Humans; Indoles; Lung Neoplasms; MAP Kinase Kinase Kinases; Mitosis; Morpholines; Nocodazole; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Wortmannin | 2006 |
Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes.
Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Antibodies, Phospho-Specific; Benzophenanthridines; Chelating Agents; Chromones; Egtazic Acid; Immunologic Factors; Immunoprecipitation; Indoles; Membrane Potentials; Morpholines; Myocytes, Smooth Muscle; Phosphatidylinositol 4,5-Diphosphate; Portal Vein; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; TRPC Cation Channels; Wortmannin | 2009 |
Insulin up-regulates heme oxygenase-1 expression in 3T3-L1 adipocytes via PI3-kinase- and PKC-dependent pathways and heme oxygenase-1-associated microRNA downregulation.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cells, Cultured; Chromones; Heme Oxygenase-1; Immunoblotting; Indoles; Insulin; Male; Mice; MicroRNAs; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleosides; Signal Transduction | 2011 |